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7. Sexually Transmitted Trichophyton mentagrophytes Genotype VII Infection among Men Who Have Sex with Men

Author

Jabet, Arnaud, Delliere, Sarah, Seang, Sophie, Chermak, Aziza, Schneider, Luminita, Chiarabini, Thibault, Teboul, Alexandre, Hickman, Geoffroy, Bozonnat, Alizee, Brin, Cecile, Favier, Marion, Tamzali, Yanis, Chasset, Francois, Barete, Stephane, Hamane, Samia, Benderdouche, Mazzouz, Moreno- Sabater, Alicia, Dannaoui, Eric, Hennequin, Christophe, Fekkar, Arnaud, Piarroux, Renaud, Normand, Anne-Cecile, and Monsel, Gentiane

Subjects
Dermatomycoses -- Causes of -- Diagnosis, Sexually transmitted diseases -- Causes of -- Diagnosis, MSM (Men who have sex with men) -- Health aspects, Disease transmission -- Causes of, Health
Abstract

Dermatophytes are keratinophilic fungi responsible for frequent skin infections. They are transmitted either by direct contact from an infected host (human or animal) to a receptive host or from the [...]

Published
2023
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8. Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials

Author

Taylor, Carolyn, Dodwell, David, McGale, Paul, Hills, Robert K, Berry, Richard, Bradley, Rosie, Braybrooke, Jeremy, Clarke, Mike, Gray, Richard, Holt, Francesca, Liu, Zulian, Pan, Hongchao, Peto, Richard, Straiton, Ewan, Coles, Charlotte, Duane, Fran, Hennequin, Christophe, Jones, Glenn, Kühn, Thorsten, Oliveros, Sileida, Overgaard, Jens, Pritchard, Kathy I, Suh, Chang-Ok, Beake, Graham, Boddington, Clare, Davies, Christina, Davies, Lucy, Evans, Vaughan, Gay, Jo, Gettins, Lucy, Godwin, Jon, James, Sam, Kerr, Amanda, Liu, Hui, MacKinnon, Elizabeth, Mannu, Gurdeep, McHugh, Theresa, Morris, Philip, Nakahara, Mariko, Read, Simon, Taylor, Hannah, Ferguson, John, Scheurlen, Hans, Zurrida, Stefano, Galimberti, Viviana, Ingle, James, Valagussa, Pinuccia, Veronesi, Umberto, Anderson, Stewart, Tang, Gong, Fisher, Bernard, Fossa, Sophie, Valborg Reinertsen, Kristin, Host, Herman, Muss, Hyman, Holli, Kaija, Albain, Kathy, Arriagada, Rodrigo, Bartlett, John, Bergsten-Nordström, Elizabeth, Bliss, Judith, Brain, Etienne, Carey, Lisa, Coleman, Robert, Cuzick, Jack, Davidson, Nancy, Del Mastro, Lucia, Di Leo, Angelo, Dignam, James, Dowsett, Mitch, Ejlertsen, Bent, Francis, Prue, García-Sáenz, José Angel, Gelber, Rich, Gnant, Michael, Goetz, Matthew, Goodwin, Pam, Halpin-Murphy, Pat, Hayes, Dan, Hill, Catherine, Jagsi, Reshma, Janni, Wolfgang, Loibl, Sibylle, Mamounas, Eleftherios, Martín, Miguel, McIntosh, Stuart, Mukai, Hirofumi, Nekljudova, Valentina, Norton, Larry, Ohashi, Yasuo, Piccart, Martine, Pierce, Lori, Raina, Vinod, Rea, Daniel, Regan, Meredith, Robertson, John, Rutgers, Emiel, Salgado, Roberto, Slamon, Dennis, Spanic, Tanja, Sparano, Joseph, Steger, Guenther, Toi, Masakazu, Tutt, Andrew, Viale, Giuseppe, Wang, Xiang, Wilcken, Nicholas, Wolmark, Norman, Yu, Ke-Da, Cameron, David, Bergh, Jonas, Swain, Sandra, Whelan, Tim, and Poortmans, Philip

Published
2023
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9. Intestinal Candida albicans overgrowth in IgA deficiency

Author

Moreno-Sabater, Alicia, Sterlin, Delphine, Imamovic, Lejla, Bon, Fabienne, Normand, Anne-Cecile, Gonnin, Cecile, Gazzano, Marianne, Bensalah, Merieme, Dorgham, Karim, Ben Salah, Elyes, Acherar, Aniss, Parizot, Christophe, Rigourd, Virginie, Begue, Hervé, Dalle, Frederic, Bachmeyer, Claude, Hennequin, Christophe, Yssel, Hans, Malphettes, Marion, Fieschi, Claire, Fadlallah, Jehane, and Gorochov, Guy

Published
2023
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13. Highly hypofractionated schedules for localized prostate cancer: Recommendations of the GETUG radiation oncology group

Author

Lapierre, Ariane, Hennequin, Christophe, Beneux, Amandine, Belhomme, Sarah, Benziane Ouaritini, Nicolas, Biston, Marie-Claude, Crehange, Gilles, de Crevoisier, Renaud, Dumas, Jean-luc, Fawzi, Maher, Lisbona, Albert, Pasquier, David, Pelissier, Sandra, Graff-Cailleaud, Pierre, Pommier, Pascal, Sargos, Paul, Simon, Jean-Marc, Supiot, Stéphane, Tantot, Florence, and Chapet, Olivier

Published
2022
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16. Actualités réglementaires en radiothérapie en France en 2024 : enjeux de qualité et sécurité des soins.

Author

Bourgier, Céline, Hennequin, Christophe, Leroy, Thomas, and Lorchel, Fabrice

Subjects
*RADIOTHERAPY, *TECHNOLOGICAL innovations, *AUDITING, *CLINICAL trials
Abstract

Forte des nombreuses innovations cliniques, technologiques ou stratégiques, la radiothérapie est en évolution permanente, contribuant à des enjeux majeurs de qualité et de sécurité, dans un contexte où il est nécessaire de se conformer à de nouvelles exigences réglementaires. Nous décrivons dans cet article les conditions de mises en œuvre et d'application des exigences d'habilitation, de certification périodique et d'audit par les pairs en France. With numerous clinical, technological or strategic innovations, radiation therapy is constantly evolving, contributing to major quality and safety issues, in a context where new regulatory standards are required. In this article, we will describe the conditions for implementing and applying the requirements for accreditation, periodic certification and peer audit in France. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Extensive Dermatophytosis Caused by Terbinafine-Resistant Trichophyton indotineae, France

Author

Jabet, Arnaud, Brun, Sophie, Normand, Anne-Cecile, Imbert, Sebastien, Akhoundi, Mohammad, Dannaoui, Eric, Audiffred, Laeticia, Chasset, Francois, Izri, Arezki, Laroche, Liliane, Piarroux, Renaud, Bachmeyer, Claude, Hennequin, Christophe, and Sabater, Alicia Moreno

Subjects
Dermatomycoses -- Causes of -- Drug therapy, Ascomycota -- Identification and classification -- Distribution -- Genetic aspects, Terbinafine -- Usage, Drug resistance in microorganisms -- Causes of, Fungi -- Identification and classification -- Distribution -- Genetic aspects, Company distribution practices, Health
Abstract

In recent years, dermatologists in India have alerted the medical community to the wide spread of recalcitrant extensive dermatophytosis across the country. Clinically, extensive dermatophytosis is characterized by tinea cruris, [...]

Published
2022
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18. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study

Author

Gangneux, Jean-Pierre, Dannaoui, Eric, Fekkar, Arnaud, Luyt, Charles-Edouard, Botterel, Françoise, De Prost, Nicolas, Tadié, Jean-Marc, Reizine, Florian, Houzé, Sandrine, Timsit, Jean-François, Iriart, Xavier, Riu-Poulenc, Béatrice, Sendid, Boualem, Nseir, Saad, Persat, Florence, Wallet, Florent, Le Pape, Patrice, Canet, Emmanuel, Novara, Ana, Manai, Melek, Cateau, Estelle, Thille, Arnaud W, Brun, Sophie, Cohen, Yves, Alanio, Alexandre, Mégarbane, Bruno, Cornet, Muriel, Terzi, Nicolas, Lamhaut, Lionel, Sabourin, Estelle, Desoubeaux, Guillaume, Ehrmann, Stephan, Hennequin, Christophe, Voiriot, Guillaume, Nevez, Gilles, Aubron, Cécile, Letscher-Bru, Valérie, Meziani, Ferhat, Blaize, Marion, Mayaux, Julien, Monsel, Antoine, Boquel, Frédérique, Robert-Gangneux, Florence, Le Tulzo, Yves, Seguin, Philippe, Guegan, Hélène, Autier, Brice, Lesouhaitier, Matthieu, Pelletier, Romain, Belaz, Sorya, Bonnal, Christine, Berry, Antoine, Leroy, Jordan, François, Nadine, Richard, Jean-Christophe, Paulus, Sylvie, Argaud, Laurent, Dupont, Damien, Menotti, Jean, Morio, Florent, Soulié, Marie, Schwebel, Carole, Garnaud, Cécile, Guitard, Juliette, Le Gal, Solène, Quinio, Dorothée, Morcet, Jeff, Laviolle, Bruno, Zahar, Jean-Ralph, and Bougnoux, Marie-Elisabeth

Published
2022
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22. Characteristics and outcome according to underlying disease in non-AIDS patients with acute respiratory failure due to Pneumocystis pneumonia

Author

Burghi, Gaston, Biard, Lucie, Roux, Antoine, Valade, Sandrine, Robert-Gangneux, Florence, Hamane, Samia, Maubon, Daniéle, Debourgogne, Anne, Le Gal, Soléne, Dalle, Fréderic, Leterrier, Marion, Toubas, Dominique, Pomares, Christelle, Bellanger, Anne Pauline, Bonhomme, Julie, Berry, Antoine, Iriart, Xavier, Durand-Joly, Isabelle, Magne, Denis, Pons, Denis, Hennequin, Christophe, Maury, Eric, Azoulay, Elie, and Lemiale, Virginie

Published
2021
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28. French recommendations on strategies for preventing and treating osteoporosis induced by adjuvant breast cancer therapies

Author

Bouvard, Béatrice, Confavreux, Cyrille B., Briot, Karine, Bonneterre, Jacques, Cormier, Catherine, Cortet, Bernard, Hannoun-Lévi, Jean-Michel, Hennequin, Christophe, Javier, Rose-Marie, Kerbrat, Pierre, Lespessailles, Eric, Lesur, Anne, Mayeur, Didier, Paccou, Julien, Trémollières, Florence, Vieillard, Marie-Hélène, and Debiais, Françoise

Published
2019
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29. French recommendations for osteoporosis prevention and treatment in patients with prostate cancer treated by androgen deprivation

Author

Briot, Karine, Paccou, Julien, Beuzeboc, Philippe, Bonneterre, Jacques, Bouvard, Béatrice, Confavreux, Cyrille B., Cormier, Catherine, Cortet, Bernard, Hannoun-Lévi, Jean-Michel, Hennequin, Christophe, Javier, Rose-Marie, Lespessailles, Eric, Mayeur, Didier, Mongiat Artus, Pierre, Vieillard, Marie-Hélène, and Debiais, Françoise

Published
2019
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30. Prognostic Biomarkers Used for Localised Prostate Cancer Management: A Systematic Review

Author

Lamy, Pierre-Jean, Allory, Yves, Gauchez, Anne-Sophie, Asselain, Bernard, Beuzeboc, Philippe, de Cremoux, Patricia, Fontugne, Jacqueline, Georges, Agnès, Hennequin, Christophe, Lehmann-Che, Jacqueline, Massard, Christophe, Millet, Ingrid, Murez, Thibaut, Schlageter, Marie-Hélène, Rouvière, Olivier, Kassab-Chahmi, Diana, Rozet, François, Descotes, Jean-Luc, and Rébillard, Xavier

Published
2018
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31. Molecular epidemiology of Candida africana isolates collected from vagina swabs in French Guiana.

Author

Bigot, Jeanne, Kalboussi, Yasmine, Bonkoto Nkoy, Yannick, Benmostefa, Alexis, Vellaissamy, Sandra, Benzerara, Laurent, Sainte-Rose, Vincent, Blanchet, Denis, Demar, Magalie, Guitard, Juliette, and Hennequin, Christophe

Abstract

Previous molecular studies have shown that Candida africana corresponds to the clade 13 of Candia albicans. It has been mostly involved in vulvovaginal candidiasis worldwide but few data exist in South America. The aim of our study was to investigate the prevalence of C. africana in women living in French Guiana. For this, we first set up a fluorescent-intercalating-dye-real time Polymerase Chain Reaction (PCR) targeting the hyphal wall protein 1 gene. The test was applied to 212 C. albicans isolates collected from May to August 2019 from vaginal swabs, allowing the identification of six women harboring C. africana (eight isolates). The in vitro susceptibility of these eight isolates to six antifungal drugs was also evaluated. No demographics or clinical-specific features could be demonstrated. Genetic diversity of those isolates was analyzed through multilocus sequence typing and showed that diploid sequence type 182 was predominant (n  = 6) and allowed the report of a new diploid sequence type. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Stereotactic radiation therapy in the strategy of treatment of metastatic renal cell carcinoma: A study of the Getug group

Author

Meyer, Emmanuel, Pasquier, David, Bernadou, Guillemette, Calais, Gilles, Maroun, Pierre, Bossi, Alberto, Theodore, Christine, Albiges, Laurence, Stefan, Dinu, de Crevoisier, Renaud, Hennequin, Christophe, Lagrange, Jean-Léon, Grellard, Jean-Michel, Clarisse, Bénédicte, Licaj, Idlir, Habrand, Jean-Louis, Carrie, Christian, and Joly, Florence

Published
2018
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41. Long-term results of dose escalation (80 vs 70 Gy) combined with long-term androgen deprivation in high-risk prostate cancers: GETUG-AFU 18 randomized trial.

Author

Hennequin, Christophe, Sargos, Paul, Roca, Lise, Silva, Marlon, Latorzeff, Igor, Peiffert, Didier, Cozzi, Salvatore, Benyoucef, Ahmed, Hasbini, Ali, Supiot, Stephane, Ronchin, Philippe, Wachter, Thierry, Azria, David, Cailleux, Pierre-Etienne, Cormier, Luc, Zibouche, Mallik, and Pigné, Grégoire

Published
2024
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43. ß-D-Glucan Assay in the Cerebrospinal Fluid for the Diagnosis of Non-cryptococcal Fungal Infection of the Central Nervous System: A Retrospective Multicentric Analysis and a Comprehensive Review of the Literature.

Author

Bigot, Jeanne, Leroy, Jordan, Chouaki, Taieb, Cholley, Laurence, Bigé, Naïke, Tabone, Marie-Dominique, Brissot, Eolia, Thorez, Sophie, Maizel, Julien, Dupont, Hervé, Sendid, Boualem, Hennequin, Christophe, and Guitard, Juliette

Subjects
BIOMARKERS, RESEARCH, ACADEMIC medical centers, CONFIDENCE intervals, RETROSPECTIVE studies, CENTRAL nervous system infections, COMPARATIVE studies, BETA-glucans, MYCOSES, DESCRIPTIVE statistics, SENSITIVITY & specificity (Statistics), DIAGNOSTIC errors, BACTERIAL diseases, EVALUATION
Abstract

Background Except for cryptococcosis, fungal infection of the central nervous system (FI-CNS) is a rare but severe complication. Clinical and radiological signs are non-specific, and the value of conventional mycological diagnosis is very low. This study aimed to assess the value of β1,3-D-glucan (BDG) detection in the cerebrospinal fluid (CSF) of non-neonatal non-cryptococcosis patients. Methods Cases associated with BDG assay in the CSF performed in 3 French University Hospitals over 5 years were included. Clinical, radiological, and mycological results were used to classify the episodes as proven/highly probable, probable, excluded, and unclassified FI-CNS. Sensitivity and specificity were compared to that calculated from an exhaustive review of the literature. Results In total, 228 episodes consisting of 4, 7, 177, and 40 proven/highly probable, probable, excluded, and unclassified FI-CNS, respectively, were analysed. The sensitivity of BDG assay in CSF to diagnose proven/highly probable/probable FI-CNS ranged from 72.7% [95% confidence interval {CI}: 43.4%‒90.2%] to 100% [95% CI: 51%‒100%] in our study and was 82% in the literature. For the first time, specificity could be calculated over a large panel of pertinent controls and was found at 81.8% [95% CI: 75.3%‒86.8%]. Bacterial neurologic infections were associated with several false positive results Conclusions Despite its sub-optimal performance, BDG assay in the CSF should be added to the diagnostic armamentarium for FI-CNS. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Clinical outcomes of adapted hypofractionated radiotherapy for bladder cancer in elderly patients.

Author

Mignot, Fabien, Fabiano, Emmanuelle, Xylinas, Evanguelos, Alati, Aurélia, Méjean, Arnaud, Masson‐Lecomte, Alexandra, Hermieu, Jean‐François, Desgrandchamps, François, Hennequin, Christophe, Durdux, Catherine, and Quéro, Laurent

Subjects
OLDER patients, TRANSURETHRAL prostatectomy, RADIOTHERAPY, BLADDER cancer, TREATMENT effectiveness, TRANSURETHRAL resection of bladder, CANCER patients, CANCER radiotherapy
Abstract

Objective: To investigate the feasibility, efficacy, and safety of trimodal therapy (TMT) using a bifractionated split‐course hypofractionated radiotherapy (RT) for non‐metastatic muscle‐invasive bladder cancer (MIBC) in elderly patients. Patients and Methods: We retrospectively reviewed the characteristics and outcomes of patients aged >75 years with non‐metastatic MIBC suitable or not for radical cystectomy (RC) and treated with transurethral resection of bladder tumour followed by concomitant radio‐chemotherapy (platinum salt and 5‐fluorouracil) at two institutions (Saint Louis Hospital, Paris, France and European Georges Pompidou Hospital, Paris, France) between 1990 and 2021. RT consisted of an adapted bifractionated split‐course hypofractionated RT. Acute toxicities were reported according to Common Terminology Criteria for Adverse Events version 5.0 and late toxicities were reported according to the Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer late radiation morbidity scoring schema. The primary end‐point was overall survival (OS). Secondary end‐points included other survivals outcomes and safety. Results: A total of 122 patients were identified, with a median (range) follow‐up of 51.1 (0.5–210.8) months. In all, 83.5% of patients completed radio‐chemotherapy. The OS rate was 61.7% at 3 years and 51.2% at 5 years. In multivariate analysis, the completion of RT and concomitant chemotherapy were significantly associated with better OS and cancer‐specific survival. For patients fit for RC, a complete histological response was achieved for 77 patients (91.7%) with radio‐chemotherapy and the bladder conservation rate was 90.5%. Acute and late Grade ≥3 toxicities were <5%. Conclusion: Bifractionated split‐course hypofractionated RT with concomitant chemotherapy regimen appears to be well‐tolerated and effective. Trimodal treatment seems to be a curative option for elderly patients unfit for radical surgery compared with palliative care and may contribute to improved survival in these patients. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Digestive fungal flora in asymptomatic subjects in Bobo-Dioulasso, Burkina Faso

Author

Bamba Sanata, Ouédraogo Abdoul Salam, Sangaré Ibrahim, Zida Adama, Cissé Mamoudou, Karou D. Simplice, Simpore Jacques, Guiguemdé T. Robert, and Hennequin Christophe

Subjects
Candida, Mass spectrometry, Matrix-assisted laser desorption ionization-time of flight, Bobo-Dioulasso, Arctic medicine. Tropical medicine, RC955-962, Biology (General), QH301-705.5
Abstract

Objective: To identify Candida species in asymptomatic subjects in Bobo-Dioulasso (Burkina Faso) by the matrix-assisted laser desorption ionization-time of flight mass spectrometry. Methods: A cross-sectional study was conducted from January to February 2013 in Bobo-Dioulasso to collect fecal and urine specimens from voluntary donors. Fungal strains were isolated on Sabouraud dextrose agar and analyzed using matrix-assisted laser desorption ionisation-time-of-flight mass spectrometry. Results: A total of 135 samples including stools (78.5%, 106/135) and urine (21.5%, 29/135) were analyzed. The results revealed that fecal specimens contained mainly Candida krusei (C. krusei) (42.5%) followed by Candida albicans (29.3%), Candida glabrata (18.0%) and Candida tropicalis (C. tropicalis) (4.7%). C. krusei (34.6%) was also found to be the most frequently identified in urine samples followed by Candida albicans (27.0%), C. tropicalis (15.4%) and Candida parapsilosis. However, uncommon species such as Candida nivariensis, Candida kefyr, Candida norvegensis, Candida parapsilosis, Candida lusitaniae and Candida robusta were also identified from fecal and urines samples. Conclusions: This study noted the emergence of species such as C. krusei, Candida glabrata, Candida parapsiolosis, C. tropicalis, Candida nivariensis, Candida norvegensis, and others. It is an imperative to take into account the existence of these species in the therapeutic management of patients in Bobo-Dioulasso.

Published
2014
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