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482 results on '"Hemingway, Janet"'

1. LLIN Evaluation in Uganda Project (LLINEUP)–effects of a vector control trial on Plasmodium infection prevalence and genotypic markers of insecticide resistance in Anopheles vectors from 48 districts of Uganda

Author

Lynd, Amy, Gonahasa, Samuel, Staedke, Sarah G., Oruni, Ambrose, Maiteki-Sebuguzi, Catherine, Hancock, Penelope A., Knight, Erin, Dorsey, Grant, Opigo, Jimmy, Yeka, Adoke, Katureebe, Agaba, Kyohere, Mary, Hemingway, Janet, Kamya, Moses R., McDermott, Daniel, Lucas, Eric R., and Donnelly, Martin J.

Published
2024
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4. Global water quality changes posing threat of increasing infectious diseases, a case study on malaria vector Anopheles stephensi coping with the water pollutants using age-stage, two-sex life table method

Author

Fazeli-Dinan, Mahmoud, Azarnoosh, Mostafa, Özgökçe, Mehmet Salih, Chi, Hsin, Hosseini-Vasoukolaei, Nasibeh, Haghi, Farzad Motevalli, Zazouli, Mohamad Ali, Nikookar, Seyed Hassan, Dehbandi, Reza, Enayati, Ahmadali, Zaim, Morteza, and Hemingway, Janet

Published
2022
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5. LLIN evaluation in Uganda project (LLINEUP): The fabric integrity, chemical content and bioefficacy of long-lasting insecticidal nets treated with and without piperonyl butoxide across two years of operational use in Uganda

Author

Mechan, Frank, Katureebe, Agaba, Tuhaise, Violet, Mugote, Martin, Oruni, Ambrose, Onyige, Ismail, Bumali, Kawesa, Thornton, Jonathan, Maxwell, Kilama, Kyohere, Mary, Kamya, Moses R., Mutungi, Peter, Kigozi, Simon P., Yeka, Adoke, Opigo, Jimmy, Maiteki-Sebuguzi, Catherine, Gonahasa, Samuel, Hemingway, Janet, Dorsey, Grant, Reimer, Lisa J., Staedke, Sarah G., Donnelly, Martin J., and Lynd, Amy

Published
2022
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8. AWZ1066S, a highly specific anti- Wolbachia drug candidate for a short-course treatment of filariasis

Author

Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., and O’Neill, Paul M.

Published
2019

12. Response

Author

Hemingway, Janet

Published
2018

13. Impact of insecticide resistance in Anopheles arabiensis on malaria incidence and prevalence in Sudan and the costs of mitigation

Author

Kafy, Hmooda Toto, Ismail, Bashir Adam, Mnzava, Abraham Peter, Lines, Jonathan, Abdin, Mogahid Shiekh Eldin, Eltaher, Jihad Sulieman, Banaga, Anuar Osman, West, Philippa, Bradley, John, Cook, Jackie, Thomas, Brent, Subramaniam, Krishanthi, Hemingway, Janet, Knox, Tessa Bellamy, Malik, Elfatih M., Yukich, Joshua O., Donnelly, Martin James, and Kleinschmidt, Immo

Published
2017

17. Albendazole and antibiotics synergize to deliver short-course anti- Wolbachia curative treatments in preclinical models of filariasis

Author

Turner, Joseph D., Sharma, Raman, Al Jayoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Priestley, Richard S., Murphy, Emma A., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., McCall, John, Ford, Louise, Hemingway, Janet, Ward, Stephen A., and Taylor, Mark J.

Published
2017

30. Malaria Control with Genetically Manipulated Insect Vectors

Author

Alphey, Luke, Ben Beard, C., Billingsley, Peter, Coetzee, Maureen, Crisanti, Andrea, Curtis, Chris, Eggleston, Paul, Godfray, Charles, Hemingway, Janet, Jacobs-Lorena, Marcelo, James, Anthony A., Kafatos, Fotis C., Mukwaya, Louis G., Paton, Michael, Powell, Jeffrey R., Schneider, William, Scott, Thomas W., Sina, Barbara, Sinden, Robert, Sinkins, Steven, Spielman, Andrew, Touré, Yeya, and Collins, Frank H.

Published
2002

37. An operational framework for insecticide resistance management planning

Author

Chanda, Emmanuel, Thomsen, Edward K., Musapa, Mulenga, Kamuliwo, Mulakwa, Brogdon, William G., Norris, Douglas E., Masaninga, Freddie, Wirtz, Robert, Sikaala, Chadwick H., Muleba, Mbanga, Craig, Allen, Govere, John M., Ranson, Hilary, Hemingway, Janet, Seyoum, Aklilu, Macdonald, Michael B., and Coleman, Michael

Subjects
Infection control, Mosquitoes -- Control, Insecticide resistance -- Forecasts and trends, Market trend/market analysis, Health
Abstract

Emerging and reemerging infectious diseases are often transmitted by arthropod vectors (1,2). A primary strategy to reduce vectorborne disease transmission is the use of insecticides for public health. However, resistance [...]

Published
2016
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39. Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment

Author

Quek, Shannon, Cook, Darren, Wu, Yang, Marriott, Amy, Steven, Andrew, Johnston, Kelly, Ford, Louise, Archer, John, Hemingway, Janet, Ward, Steve, Wagstaff, Simon, Turner, Joseph, and Taylor, Mark

Subjects
wc_880, qx_20, qw_150
Abstract

Lymphatic filariasis is a vector-borne neglected tropical disease prioritized for global elimination. The filarial nematodes that cause the disease host a symbiotic bacterium, Wolbachia, which has been targeted using antibiotics, leading to cessation of parasite embryogenesis, waning of circulating larvae (microfilariae [mf]), and gradual cure of adult infection. One of the benefits of the anti-Wolbachia mode of action is that it avoids the rapid killing of mf, which can drive inflammatory adverse events. However, mf depleted of Wolbachia persist for several months in circulation, and thus patients treated with antibiotics are assumed to remain at risk for transmitting infections. Here, we show that Wolbachia-depleted mf rapidly lose the capacity to develop in the mosquito vector through a defect in exsheathment and inability to migrate through the gut wall. Transcriptomic and Western blotting analyses demonstrate that chitinase, an enzyme essential for mf exsheathment, is down-regulated in Wolbachia-depleted mf and correlates with their inability to exsheath and escape the mosquito midgut. Supplementation of in vitro cultures of Wolbachia-depleted mf with chitinase enzymes restores their ability to exsheath to a similar level to that observed in untreated mf. Our findings elucidate a mechanism of rapid transmission-blocking activity of filariasis after depletion of Wolbachia and adds to the broad range of biological processes of filarial nematodes that are dependent on Wolbachia symbiosis.

Published
2022

41. Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

Author

Biagini, Giancarlo A., Fisher, Nicholas, Shone, Alison E., Mubaraki, Murad A., Srivastava, Abhishek, Hill, Alisdair, Antoine, Thomas, Warman, Ashley J., Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K., Leung, Suet C., Sharma, Raman, Gibbons, Peter, Hong, David W., Pacorel, Bénédicte, Lawrenson, Alexandre S., Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A., Nixon, Gemma L., Chadwick, James, Hemingway, Janet, Delves, Michael J., Sinden, Robert E., Zeeman, Anne-Marie, Kocken, Clemens H. M., Berry, Neil G., O'Neill, Paul M., and Ward, Stephen A.

Published
2012

43. Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

Author

Arensburger, Peter, Megy, Karine, Waterhouse, Robert M., Abrudan, Jenica, Amedeo, Paolo, Antelo, Beatriz, Bartholomay, Lyric, Bidwell, Shelby, Caler, Elisabet, Camara, Francisco, Campbell, Corey L., Campbell, Kathryn S., Casola, Claudio, Castro, Marta T., Chandramouliswaran, Ishwar, Chapman, Sinéad B., Christley, Scott, Costas, Javier, Eisenstadt, Eric, Feschotte, Cedric, Fraser-Liggett, Claire, Guigo, Roderic, Haas, Brian, Hammond, Martin, Hansson, Bill S., Hemingway, Janet, Hill, Sharon R., Howarth, Clint, Ignell, Rickard, Kennedy, Ryan C., Kodira, Chinnappa D., Lobo, Neil F., Mao, Chunhong, Mayhew, George, Michel, Kristin, Mori, Akio, Liu, Nannan, Naveira, Horado, Nene, Vishvanath, Nguyen, Nam, Pearson, Matthew D., Pritham, Ellen J., Puiu, Daniela, Qi, Yumin, Ranson, Hilary, Ribeiro, Jose M. C., Roberston, Hugh M., Severson, David W., Shumway, Martin, Stanke, Mario, Strausberg, Robert L., Sun, Cheng, Sutton, Granger, Tubio, Jose Manuel C., Unger, Maria F., Vanlandingham, Dana L., Vilella, Albert J., White, Owen, White, Jared R., Wondji, Charles S., Wortman, Jennifer, Zdobnov, Evgeny M., Birren, Bruce, Christensen, Bruce M., Collins, Frank H., Cornel, Anthony, Dimopoulos, George, Hannick, Linda I., Higgs, Stephen, Lanzaro, Gregory C., Lawson, Daniel, Lee, Norman H., Muskavitch, Marc A. T., Raikhel, Alexander S., and Atkinson, Peter W.

Published
2010

44. Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens

Author

Bartholomay, Lyric C., Waterhouse, Robert M., Mayhew, George F., Campbell, Corey L., Michel, Kristin, Zou, Zhen, Ramirez, Jose L., Das, Suchismita, Alvarez, Kanwal, Arensburger, Peter, Bryant, Bart, Chapman, Sinead B., Dong, Yuemei, Erickson, Sara M., Karunaratne, S. H. P. Parakrama, Kokoza, Vladimir, Kodira, Chinnappa D., Pignatelli, Patricia, Shin, Sang Woon, Vanlandingham, Dana L., Atkinson, Peter W., Birren, Bruce, Christophides, George K., Clem, Rollie J., Hemingway, Janet, Higgs, Stephen, Megy, Karine, Ranson, Hilary, Zdobnov, Evgeny M., Raikhel, Alexander S., Christensen, Bruce M., Dimopoulos, George, and Muskavitch, Marc A. T.

Published
2010

45. Acceptability and perceived side effects of insecticide indoor residual spraying under different resistance management strategies

Author

Rodríguez Américo David, Penilla Rosa Patricia, Rodríguez Mario Henry, Hemingway Janet, Trejo Antonio, and Hernández-Avila Juan Eugenio

Subjects
indoor insecticide spraying, acceptability, side-effects, Mexico, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: To assess household acceptability and perceived side effects of residual indoor pyrethroid (PYR), carbamate and organophosphate insecticides sprayed by annual rotation (ROT), spatial mosaic (MOS), and a single insecticide (DDT or PYR) in communities of the coastal plain of Chiapas, Mexico. MATERIAL AND METHODS: A questionnaire to assess the acceptability and perceived side effects of indoor insecticides was administered to one member of 30% of the families in eight villages of Chiapas. The association of different insecticide treatments with their responses was evaluated (Chi-square). The intensity of side effects indicated under different treatments was compared in an ordered logistic model, using a severity index as the response variable. RESULTS: Insecticide spraying as a probable cause of symptoms was identified by 2.1% of interviewees. A significantly high percentage of persons with blurred vision, dizziness, sneezing, coughing, numbness, watery eyes, and itching lived in villages under MOS and ROT and a high severity index was significantly associated with ROT treatment. Reduction of mosquito bites and cockroaches were the perceived main benefits, and most villagers that perceived no benefits lived in DDT treated villages. Most of the interviewees welcomed spraying (83.7%), but the smell and having to remove furniture from houses were the main arguments against it. CONCLUSIONS: Acceptability correlated with insecticide spray coverage, although the most frequent suggestion for improvement was to increase the understanding of the objectives of spraying in the communities. The frequency of side effects was low, but higher in localities where a combination of insecticides was applied. This is a limitation for the use of this type of resistance management strategy in public health.

Published
2006

46. Knowledge and beliefs about malaria transmission and practices for vector control in Southern Mexico

Author

Rodríguez Américo David, Penilla Rosa Patricia, Henry-Rodríguez Mario, Hemingway Janet, Betanzos Angel Francisco, and Hernández-Avila Juan Eugenio

Subjects
malaria, knowledge, attitudes, practice, culicidae, Mexico, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: To investigate the knowledge and beliefs about malaria transmission and practices for vector control in eight villages on the coastal plain of Chiapas, Mexico. MATERIAL AND METHODS: A cross-sectional survey was conducted during May and June 1995 in Chiapas, Mexico. A questionnaire to investigate family structure, knowledge on malaria transmission, preventive measures and attitudes towards seeking treatment was applied to both family heads of a sample of households. Associations were analyzed by estimating odds ratios with confidence intervals and p values, using bivariate and multivariate logistic regression methods. RESULTS: Malaria knowledge was poor and only 48% associated malaria with mosquito bites. The perceived benefit of indoor residual spraying was associated to a reduction of mosquitoes, a reduction in the numbers of cockroaches and rats, but only 3% associated it directly with the prevention of malaria transmission. Most villagers (97.6%) agreed with the indoor residual spraying of insecticides. Ninety nine percent of villagers had mosquito bednets, 75.7% used them all year round. Other measures used by villagers to prevent mosquito bites were smoke and mosquito coils. Above 40% of villagers self-medicated when any member of the family had a fever episode, but 51% attended proper health services (community dispensary, private physician, health worker). About 61% used pesticides for agricultural or livestock purposes and 55% applied them themselves. Women had a greater participation as family health promoters, with 70% of the housewives being in charge of the application of self-protection preventive measures. CONCLUSIONS: Educational programs aimed at increasing awareness on the participation of mosquitoes on malaria transmission could promote community participation in malaria control in the region.

Published
2003

49. 0734 Cost-effectiveness analysis of PBO-LLINs compared to Non PBO LLINs in the reduction of malaria among children in Jinja district

Author

Kaakyo, M, Muhumuza, C, Gonahasa, S, Hemingway, Janet, Donnelly, Martin, Kamya, M, Staedke, S, and Kagaayi, J

Subjects
wa_395, wc_765, wc_750, ws_100
Abstract

appears in Infection Prevention & Control / International Journal of Infectious Diseases 101(S1) (2021) 300–335\ud \ud the organizers of the 19th International Congress on Infectious Diseases (ICID) made the decision to cancel the Congress scheduled for September 10-13, 2020 in Kuala Lumpur, Malaysia

Published
2020

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