1. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults : a cross-sectional mega-analysis
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Paul Pauli, Alberdingk M.H. Onnink, Hyagriv Simhan, Karen Sirocco, Richard Todd, Laura Heinichen, Tomáš Paus, Josep Antoni Ramos-Quiroga, April German, Yuliya S. Nikolova, Robert Asarnow, Baiyan Li, Sami Somo, Gustavo Sudre, Joseph O'Neil, Laura Martin, Kelly Botteron, Michael P. Milham, Kaylita Chantiluke, Arthur W. Toga, Denise Milovan, Aaron A. Wilber, Marcel P. Zwiers, Lindsay Walker, Daniel Brandeis, James T. McCracken, Kerstin J. Plessen, Hilda Volero, Stewart H. Mostofsky, Barbara Franke, Dah Jyuu Wang, Kathryn Hirabayashi, Yannis Paloyelis, Thomas Frodl, Kimm J. E. van Hulzen, Stan Zammit, Lizanne S.J. Schweren, E. Mark Mahone, Keri S. Rosch, Carlo Pierpaoli, Joseph O'Neill, Jacki Marmor, Paul M. Thompson, David Fadale, Annette Conzelmann, John Van Meter, Terry L. Jernigan, Elena Shumskaya, Wenjun Zhang, Peter Davis, Amy Taylor, Sara Ambrosino, Paulo Mattos, Cara McCormack, Jason Royal, Jack Euesden, Sarah Baumeister, Ana Cubillo, Pamela K. Douglas, Patrick de Zeeuw, Sherif Karama, Janneke Dammers, Eileen Oberwelland, Tomoyuki Nishino, Kathrin C. Zierhut, Janice Newman, Xiuxia Qu, Thomas Wolfers, Hongtu Zhu, Tuong Vi Nguyen, Anna Weber Byars, William S. Ball, Martha O Wang, Charlotte E Vorwald, Jeffry R. Jeffrey Alger, Ravi Bansal, Laurence Stanford, Catharina A. Hartman, David Dean, Astri J. Lundervold, Eric J Mott, Adriana Di Martino, Kenneth Hugdahl, Jack M. Fletcher, Brock Medsker, Matthew D. Albaugh, Erick Forno, Robert C. McKinstry, Ying Liu, Kerstin Konrad, Wendy Bommer, Michael Rubart, Mariam Zentis, Dirk J. Heslenfeld, S. Thameem Dheen, Stephen M. Smith, Judith Rumsey, Jaap Oosterlaan, Xin-yuan Fu, Corinde E. Wiers, Hamidreza Mehdizadeh, Francisco X. Castellanos, Edward Moss, Peter J. Basser, Oscar Vilarroya, Deqiang Li, Brooke Bintliff, Eszter Szekely, Wuqiang Zhu, Ivanei E. Bramati, Sarah Hohmann, Lisa Freund, Jochen Seitz, Joan Carles Soliva, Cedric Ireland, Xie Li, Helen Brinson, Gregor Kohls, Samir Das, C Juan, Deborah Waber, William Warren, George Davey Smith, Michael P. Froimowitz, Long-sheng Song, G. Bruce Pike, Nicholas Lange, Marcus R. Munafò, Larry A. Kramer, Lauren Baskir, Klaus-Peter Lesch, K. Mochizuki, J. M. Mateos-Pérez, Ni Yin, Simon Ducharme, Philip Asherson, Marylynn Snyder, Aurelie Labbe, Janita Bralten, Yue Tang, J Jillian, Giovanna Spinella, Anders M. Dale, Kathleen M. Hebert, Cheryl Rainey, Stan Henderson, T. Kubota, Robert A. Zimmerman, Katrina Gwinn-Hardy, Andrew J. Schork, Andreas Reif, Maureen L Dreher, Pieter J. Hoekstra, Hazel McCarthy, John Constantino, Martha B. Denckla, April Carr, Hanying Chen, Chen Guan Koay, Marie F. Høvik, Richard Robertson, Jan Haavik, C. Robert Almli, Derrek P. Hibar, Joseph Biederman, Neda Jahanshad, Yuliya N. Yoncheva, Seshadri Ramya, James J. Hudziak, Eric M Brey, Larry J. Seidman, Mitul A. Mehta, Walter Stünkel, Neil Davies, Yolanda Vives-Gilabert, Ronald Whiteman, Alex Zijdenbos, Georg von Polier, Georgette A Quackenbush, Diane Dubois, Martine Hoogman, Ruth Bradford, Weinian Shou, Ramona Baur, Kathleen Durkin, Gabriel Leonard, D. Louis Collins, Tobias Banaschewski, Ali Cinar, Jeanette C. Mostert, Theo G.M. van Erp, Yap Seng Chong, Grace Yang, Dario Vins, N. Hariya, Karla Smith, Christine Mrakotsky, Alan C. Evans, Michael E. Brandt, Katya Rubia, Ilana Leppert, Evie Stergiakouli, Jonathan Harlap, John P Fisher, Rozalia Arnaoutelis, Tish Singer, Biyi Chen, Ahmad R. Hariri, Iowa City, Philip Shaw, Hannah M Sallis, Debbie A Lawlor, Jennifer L. Edwards, Leanne Tamm, Maarten Mennes, Abigail Chiverton, Nanda Rommelse, Avijit Banik, Robert Mulkern, Martin Schulte-Rüther, Clare Kelly, Stephen V. Faraone, Sarah E. Medland, Kate Tilling, Michael J. Rivkin, Bradley S. Peterson, Julie Koo, Jonna Kuntsi, Fernanda Tovar-Moll, Luke Fu, Peking Union Medical, Mark Schapiro, Thomas E. Nichols, Vladimir Fonov, K. Miyake, Alysa E. Doyle, Jan K. Buitelaar, Gloria McAnulty, Scott Dunn, Sridhar Vajapeyam, Hannah J. Jones, Thomas Zeffiro, Sarah Durston, Margaretha Dramsdahl, Deepika Kandilya, Lin Ching Chang, Deana Crocetti, Jennifer Levitt, Faculty of Behavioural and Movement Sciences, Cognitive Psychology, IBBA, Clinical Neuropsychology, Leerstoel Orobio de Castro, Social and personality development: A transactional approach, Other departments, ARD - Amsterdam Reproduction and Development, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), RS: MHeNs - R3 - Neuroscience, and Psychiatrie & Neuropsychologie
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0301 basic medicine ,Adult ,Male ,Brain development ,Adolescent ,Internet privacy ,EPISODIC MEMORY ,Neuroimaging ,Cortical volume ,150 000 MR Techniques in Brain Function ,Public access ,03 medical and health sciences ,Young Adult ,SDG 17 - Partnerships for the Goals ,Medicine ,ADHD ,Humans ,Brain/pathology ,Longitudinal Studies ,ddc:610 ,Preschool ,Child ,Biological Psychiatry ,METAANALYSIS ,STRUCTURAL MRI ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,business.industry ,ABNORMALITIES ,Brain ,CALLOUS-UNEMOTIONAL TRAITS ,220 Statistical Imaging Neuroscience ,Attention Deficit Disorder with Hyperactivity/pathology ,Middle Aged ,DEPRESSION ,Magnetic Resonance Imaging ,AMYGDALA ,Psychiatry and Mental health ,030104 developmental biology ,Cross-Sectional Studies ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Child, Preschool ,Linear Models ,Female ,DEFICIT/HYPERACTIVITY DISORDER ,business ,MEDICATION-NAIVE CHILDREN - Abstract
Contains fulltext : 169834.pdf (Publisher’s version ) (Open Access) Contains fulltext : 169834pos.pdf (Author’s version postprint ) (Open Access) BACKGROUND: Neuroimaging studies have shown structural alterations in several brain regions in children and adults with attention deficit hyperactivity disorder (ADHD). Through the formation of the international ENIGMA ADHD Working Group, we aimed to address weaknesses of previous imaging studies and meta-analyses, namely inadequate sample size and methodological heterogeneity. We aimed to investigate whether there are structural differences in children and adults with ADHD compared with those without this diagnosis. METHODS: In this cross-sectional mega-analysis, we used the data from the international ENIGMA Working Group collaboration, which in the present analysis was frozen at Feb 8, 2015. Individual sites analysed structural T1-weighted MRI brain scans with harmonised protocols of individuals with ADHD compared with those who do not have this diagnosis. Our primary outcome was to assess case-control differences in subcortical structures and intracranial volume through pooling of all individual data from all cohorts in this collaboration. For this analysis, p values were significant at the false discovery rate corrected threshold of p=0.0156. FINDINGS: Our sample comprised 1713 participants with ADHD and 1529 controls from 23 sites with a median age of 14 years (range 4-63 years). The volumes of the accumbens (Cohen's d=-0.15), amygdala (d=-0.19), caudate (d=-0.11), hippocampus (d=-0.11), putamen (d=-0.14), and intracranial volume (d=-0.10) were smaller in individuals with ADHD compared with controls in the mega-analysis. There was no difference in volume size in the pallidum (p=0.95) and thalamus (p=0.39) between people with ADHD and controls. Exploratory lifespan modelling suggested a delay of maturation and a delay of degeneration, as effect sizes were highest in most subgroups of children (21 years): in the accumbens (Cohen's d=-0.19 vs -0.10), amygdala (d=-0.18 vs -0.14), caudate (d=-0.13 vs -0.07), hippocampus (d=-0.12 vs -0.06), putamen (d=-0.18 vs -0.08), and intracranial volume (d=-0.14 vs 0.01). There was no difference between children and adults for the pallidum (p=0.79) or thalamus (p=0.89). Case-control differences in adults were non-significant (all p>0.03). Psychostimulant medication use (all p>0.15) or symptom scores (all p>0.02) did not influence results, nor did the presence of comorbid psychiatric disorders (all p>0.5). INTERPRETATION: With the largest dataset to date, we add new knowledge about bilateral amygdala, accumbens, and hippocampus reductions in ADHD. We extend the brain maturation delay theory for ADHD to include subcortical structures and refute medication effects on brain volume suggested by earlier meta-analyses. Lifespan analyses suggest that, in the absence of well powered longitudinal studies, the ENIGMA cross-sectional sample across six decades of ages provides a means to generate hypotheses about lifespan trajectories in brain phenotypes. FUNDING: National Institutes of Health. 10 p.
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- 2017
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