17 results on '"Hashino Y"'
Search Results
2. Advanced solutions for yield improvement: 'Super PI'.
- Author
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Asai, H., Koga, Y., Une, H., Hashino, Y., Hamamoto, N., and Sakai, S.
- Subjects
MICROFABRICATION ,PLASMA etching ,ELECTRIC properties ,MANUFACTURING processes ,ION bombardment ,TRANSISTORS ,PERFORMANCE evaluation - Abstract
Some plasma processes such as etching produce non-uniform electrical characteristics during device fabrication at the front-end manufacturing process. This variation in electrical properties causes the yield of transistors to decrease. In the front-end process, ion implantation has the advantage of high-precision controllability such as dose distribution which can be used to compensate for the variation in electrical characteristics of the device. We have developed a method which can compensate for the non-uniformities caused by different front-end processes during device fabrication. Patterning Implant (PI) system is one of the procedures that utilizes a combination of beam sweeping and stepwise wafer rotations. With this approach, different dose distributions on the substrate can be achieved. However, the PI system needs several rotational steps for a ring-pattern dose distribution. In addition, the system cannot be applied to processes such as halo implantation due to tilt angle dependence. Furthermore, the required dose distribution is not always the concentric ring shape which limits the application of the conventional PI system. To address this issue, we have developed the Super PI system which can provide dose distributions of any shape without the need for wafer stepwise rotation. Performance of the Super PI was evaluated in various implant conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
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3. Cluster Ion Implantation for Process Application -Carbon Cluster co-Implantation-.
- Author
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Tanjyo, M., Nagayama, T., Onoda, H., Hamamoto, N., Umisedo, S., Koga, Y., Une, H., Maehara, N., Kawamura, Y., Hashino, Y., Nakashima, Y., Hashimoto, M., Tokoro, N., Nagai, N., Sekar, K., and Krull, W.
- Subjects
ION implantation ,CLUSTER theory (Nuclear physics) ,CARBON ,METAL oxide semiconductors ,PHOSPHORUS ,MONOMERS ,ELECTRON diffraction - Abstract
For beyond 32 nm NMOS device fabrication, Cluster Carbon co-implantation process is experimentally evaluated. It is found that using Cluster Carbon co-implantation, instead of Ge PAI plus single Carbon co-implantation, Phosphorus (P) TED was suppressed and the junction depth Xj are reduced by 10 nm for SDE condition and by 17 nm for SD condition when the Cluster Carbon effective dose 2×10
15 /cm2 . The sheet resistivity Rs of 280 Ω/sq for SDE condition is increased with the increment of the Carbon dose, but the Rs×Xj product 7156 Ω/sq·nm has a minimum value is confirmed. The difference of the Cluster Carbon co-implantation to the monomer Carbon implantation is evaluated and the Cluster Carbon PAI effect makes higher activation of the P dopnt after annealing. [ABSTRACT FROM AUTHOR]- Published
- 2011
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4. CLARIS G2: Development of Carbon Cluster Implantation.
- Author
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Nakashima, Y., Hamamoto, N., Umisedo, S., Koga, Y., Une, H., Asai, H., Maehara, N., Hashino, Y., Kawamura, Y., Hashimoto, M., Nagayama, T., Tanjyo, M., Onoda, H., Horsky, T. N., Hahto, S. K., and Sekar, K.
- Subjects
ION implantation ,CARBON ,CLUSTER theory (Nuclear physics) ,BORON ,MASS production ,COMPLEMENTARY metal oxide semiconductors ,EQUIPMENT & supplies - Abstract
Nissin's boron and carbon cluster ion implanter CLARIS G2 has been developed for the mass production of next generation CMOS devices. Development of boron cluster implant technique was presented at last IIT conference in 2008 [1]. In this paper, development of carbon cluster (C
16 Hx + and C7 Hx + ) implant technique is described. Carbon cluster implantation has been well productized in terms of throughput, beam quality and lifetime. [ABSTRACT FROM AUTHOR]- Published
- 2011
- Full Text
- View/download PDF
5. Suppression of phosphorus diffusion using cluster Carbon co-implantation.
- Author
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Nagayama, T., Onoda, H., Tanjyo, M., Hamamoto, N., Umisedo, S., Koga, Y., Maehara, N., Kawamura, Y., Nakashima, Y., Hashino, Y., Hashimoto, M., Yoshimi, H., Sezaki, S., and Nagai, N.
- Published
- 2010
- Full Text
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6. Improvement of productivity by cluster ion implanter: CLARIS.
- Author
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Tanjyo, M., Hamamoto, N., Umisedo, S., Koga, Y., Une, H., Maehara, N., Kawamura, Y., Hashino, Y., Nakashima, Y., Hashimoto, M., Nagayama, T., Onoda, H., Nagai, N., Horsky, T.N., Hahto, S.K., and Jacobson, D.C.
- Published
- 2010
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- View/download PDF
7. Effects of cluster carbon implantation at low temperature on damage recovery after rapid thermal annealing.
- Author
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Onoda, H., Hamamoto, N., Nagayama, T., Sakai, S., Tanjyo, M., Umisedo, S., Koga, Y., Maehara, N., Kawamura, Y., Nakashima, Y., Tanaka, K., Hashino, Y., Hashimoto, M., Yoshimi, H., Sezaki, S., Reyes, J., and Prussin, S.
- Published
- 2010
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8. Cluster Carbon ion implantation for NMOS device fabrication improvements.
- Author
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Tanjyo, M., Onoda, H., Nagayama, T., Hamamoto, N., Umisedo, S., Koga, Y., Une, H., Maehara, N., Kawamura, Y., Hashino, Y., Nakashima, Y., Igo, T., Hashimoto, M., Tokoro, N., and Nagai, N.
- Published
- 2010
- Full Text
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9. Direct Screening of PET Hydrolase Activity in Culture Medium Based on Turbidity Reduction.
- Author
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Ogura Y, Hashino Y, and Nakamura A
- Abstract
The development of an efficient screening method for the activity of PET-degrading enzymes represents a significant technological advance in the field of enzyme research, with the potential to facilitate the advancement of enzymes for PET recycling. By examining the stable conditions of PET suspension and enzyme production conditions, we developed a method to quantify PET-degrading enzyme activity in E. coli culture medium using turbidity reduction as an indicator. High PET concentration or ionic strength caused aggregation of PET, and the best condition for activity detection was 0.5 mg mL
-1 PET in 50 mM sodium phosphate pH 7.0. Preculture of E. coli increased the purity of enzyme secreted in medium. To evaluate the screening method, 720 colonies of the PET2-7M-H229X-F233X mutant library were analyzed and three candidates of high-activity mutants were obtained. The thermostability of the mutants could also be easily measured by measuring the residual activity after heat treatment. The H229T-F233M mutant showed 3.4 times higher degradation rate against PET film than the template enzyme at the initial time. The molecular dynamics simulation implied that the F233M mutation makes space for making an α helix and that the H229T mutation resolved the steric hindrance with Trp199. These mutations were speculated to change the angle of the Trp199 side chain of PET2 to an angle similar to that of the Trp185 of IsPETase, making it suitable for PET binding to the active center. Screening of activity using PET suspensions is compatible with robotic automation and is expected to be useful for validating computationally predicted mutations., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)- Published
- 2024
- Full Text
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10. Association of Nutritional Indices With Adverse Effects and Time-to-Treatment-Failure in Triple Therapy for Lung Cancer.
- Author
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Hashino Y, Matushita T, Hatsuyama T, Wakamoto A, Goto K, Hoshi T, Iwayama K, Ohtaki K, Toda T, and Sato H
- Subjects
- Humans, Aged, Nutrition Assessment, Retrospective Studies, Prognosis, Lung Neoplasms drug therapy, Carcinoma, Non-Small-Cell Lung drug therapy, Antineoplastic Agents therapeutic use
- Abstract
Background/aim: Recent lung cancer treatments include an immune checkpoint inhibitor (ICI) pembrolizumab, platinum-based agents, plus an additional cytotoxic anticancer agent. Nutritional indices, such as the geriatric nutritional risk index (GNRI) and the prognostic nutritional index (PNI), are known to correlate with the prognosis of cancer chemotherapy. Several previous studies have investigated the relationship between PNI and treatment response in non-small cell lung cancer patients, reporting significantly increased OS and PFS in the high PNI group before treatment. However, the relationship between the three-drug combination and GNRI/PNI is unclear. The current study aimed to investigate the association of nutritional indices with duration of treatment success and occurrence of side effects in triple therapy., Patients and Methods: Seventy-two patients with non-small cell lung cancer, treated with combination of carboplatin, pemetrexed, and pembrolizumab from November 2019 to September 30, 2022, were classified into two groups (High and Low) for GNRI and PNI, and a retrospective study was performed., Results: In terms of time-to-treatment-failure (TTF), univariate and multivariate Cox proportional hazards regression analysis showed the Low-PNI group to have significantly shorter TTF than the High-PNI group (p=0.006); multivariate analysis results also showed PNI as a factor affecting TTF (HR=2.791, 95%CI=1.362-5.721, p=0.005). On the other hand, GNRI was not shown to be a factor affecting TTF., Conclusion: PNI at the start of treatment was an independent prognostic factor affecting treatment success time (TTF) in non-small cell lung cancer patients receiving triple therapy. However, PNI was not shown to be a prognostic predictor of irAE development., (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2024
- Full Text
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11. Case Report: Case series: association between blood concentration and side effects of sotorasib.
- Author
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Shigaki R, Yoshida R, Yagita A, Nagasue K, Naraoka T, Nitanai K, Yanada H, Tenma T, Kida R, Umekage Y, Mori C, Minami Y, Sato H, Iwayama K, Hashino Y, Fukudo M, and Sasaki T
- Abstract
Introduction: Sotorasib is a crucial therapeutic agent for patients with non-small cell lung cancer (NSCLC) harboring the KRAS p.G12C mutation. Despite its efficacy, the relationship between blood sotorasib concentrations and side effects remains largely unexplored., Methods: This study enrolled five patients with KRAS p.G12C-positive NSCLC treated with sotorasib (LUMAKRAS
® Tablets, Amgen, Japan) between July 2022 and February 2023 at Asahikawa Medical University Hospital. Blood sotorasib levels were monitored, and their association with adverse events was examined, with no adjustments made to drug dosages based on these levels., Results: Variable blood sotorasib levels were observed among the participants. Notably, one patient developed interstitial pneumonitis, although a definitive attribution to sotorasib was uncertain due to prior pembrolizumab treatment. The study revealed no consistent association between blood sotorasib levels and adverse events or therapeutic outcomes, with some patients experiencing severe side effects at higher concentrations, while others did not., Conclusion: Preliminary findings suggested that monitoring blood sotorasib levels may aid in anticipating adverse events in this small cohort. However, future studies with larger sample sizes and extended follow-up periods are required to validate these initial observations. Such studies could potentially offer insights into personalized dosing strategies, thereby mitigating adverse effects and enhance patient care for individuals with KRAS p.G12C-positive NSCLC., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Shigaki, Yoshida, Yagita, Nagasue, Naraoka, Nitanai, Yanada, Tenma, Kida, Umekage, Mori, Minami, Sato, Iwayama, Hashino, Fukudo and Sasaki.)- Published
- 2023
- Full Text
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12. The Relationship Between Efficacy and Safety of Osimertinib Blood Concentration in Patients With EGFR Mutation-positive Lung Cancer: A Prospective Observational Study.
- Author
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Hashino Y, Hatsuyama T, Iwayama K, Hoshi T, Wakamoto A, Ohtaki K, Toda T, and Sato H
- Subjects
- Humans, ErbB Receptors genetics, Mutation, Protein Kinase Inhibitors adverse effects, Protein Kinase Inhibitors pharmacokinetics, Protein Kinase Inhibitors therapeutic use, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung genetics, Lung Neoplasms drug therapy, Lung Neoplasms genetics
- Abstract
Background/aim: Osimertinib blood levels and their impact on treatment continuation in patients with EGFR mutation-positive lung cancer is not known. This study investigated the drug blood levels and risk factors affecting treatment continuation., Patients and Methods: Fifty-six patients with recurrent and inoperable epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer who received Osimertinib (80 mg once daily, daily dose) between October 1, 2016, and August 31, 2021, were included. Patients were classified into two groups using a cutoff blood level of 155 ng/ml. The primary endpoint was the relationship between Osimertinib exposure and efficacy, and secondary endpoints were the relationship between Osimertinib exposure and side effects, and the effect of covariates on efficacy and blood levels., Results: The median progression-free survival (PFS) for evaluable patients in the steady-state trough concentration (C
min ss ) ≥155 ng/ml and Cmin ss <155 ng/ml groups was 18.7 months and 31.2 months. Serum albumin (Alb) levels were 3.73±0.40 g/dl and 3.93±0.28 g/dl (p=0.030), respectively, and in multivariate analysis, Alb <3.7 g/dl was associated with a hazard ratio of 5.304 (95%CI=1.431-19.66; p=0.013), indicating that Alb <3.7 g/dl significantly shortened PFS., Conclusion: Free blood concentration of Osimertinib may have been increased by a combination of factors, including decreased hepatic metabolic function and decreased albumin production caused by systemic inflammation in patients with cancer. However, there was no effect of Osimertinib Cmin ss on PFS., (Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)- Published
- 2023
- Full Text
- View/download PDF
13. A Case of Hb Aalborg ( HBB : c.223G>C) with Chronic Obstructive Pulmonary Disease: A First Familial Presentation in Japan.
- Author
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Takamura K, Komori T, Hashino Y, Suzuki T, Shiwaku A, Kikuchi H, Yamamoto M, Yamauchi H, and Yamashiro Y
- Subjects
- Female, Humans, Japan, Male, Oxygen Saturation, beta-Globins genetics, Hemoglobins, Abnormal genetics, Pulmonary Disease, Chronic Obstructive genetics
- Abstract
The proband was a male in his seventies who came to our facility because of shortness of breath. He was not anemic but presented dissociation between oxygen saturation (SpO
2 ) and partial pressure of oxygen (PaO2 ) by blood gas analysis, and also demonstrated hemoglobinopathy after measurement of Hb A1c using high performance liquid chromatography (HPLC). Twenty-three percent of unknown hemoglobin (Hb) bands were detected. After sequencing the β-globin gene, we noted a missense mutation at codon 74 ( G GC> C GC) (Gly→Arg) of the β-globin chain and he was diagnosed with Hb Aalborg ( HBB : c.223G>C). One of the proband's siblings was diagnosed to have a low SpO2 level and also diagnosed to carry Hb Aalborg; she was also mildly anemic. This is the first known familial case of Hb Aalborg in Japan. In addition to Hb Aalborg, our case had underlying chronic obstructive pulmonary disease (COPD). Herein we present this case as a rare addition to the hematological literature.- Published
- 2021
- Full Text
- View/download PDF
14. Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8 + T Cell Responses.
- Author
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Hongo A, Kanaseki T, Tokita S, Kochin V, Miyamoto S, Hashino Y, Codd A, Kawai N, Nakatsugawa M, Hirohashi Y, Sato N, and Torigoe T
- Subjects
- CD8-Positive T-Lymphocytes cytology, Cell Line, Histocompatibility Antigens Class I chemistry, Humans, Peptides chemistry, Proline chemistry, Proline immunology, CD8-Positive T-Lymphocytes immunology, Histocompatibility Antigens Class I immunology, Immunity, Cellular, Peptides immunology
- Abstract
Cytotoxic CD8
+ T lymphocytes (CTLs) recognize peptides displayed by HLA class I molecules on cell surfaces, monitoring pathological conditions such as cancer. Difficulty in predicting HLA class I ligands is attributed to the complexity of the Ag processing pathway across the cytosol and the endoplasmic reticulum. By means of HLA ligandome analysis using mass spectrometry, we collected natural HLA class I ligands on a large scale and analyzed the source-protein sequences flanking the ligands. This comprehensive analysis revealed that the frequency of proline at amino acid positions 1-3 upstream of the ligands was selectively decreased. The depleted proline signature was the strongest among all the upstream and downstream profiles. Experiments using live cells demonstrated that the presence of proline at upstream positions 1-3 attenuated CTL responses against a model epitope. Other experiments, in which N-terminal-flanking Ag precursors were confined in the endoplasmic reticulum, demonstrated an inability to remove upstream prolines regardless of their positions, suggesting a need for synergistic action across cellular compartments for making the proline signature. Our results highlight, to our knowledge, a unique role and position of proline for inhibiting downstream epitope presentation, which provides a rule for defining natural peptide-HLA class I repertoire formation and CTL responses., (Copyright © 2019 by The American Association of Immunologists, Inc.)- Published
- 2019
- Full Text
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15. Intra-articular angiofibroma of soft tissue of the knee: A case report.
- Author
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Hashino Y, Nishio J, Maeyama A, Aoki M, Nabeshima K, and Yamamoto T
- Abstract
Angiofibroma of soft tissue (AFST) is an extremely rare soft tissue neoplasm that typically presents as a slow-growing, painless mass in the extremities. The present study reports an unusual case of an intra-articular AFST occurring in the left knee of a 23-year-old female. Physical examination revealed a 3-cm, relatively mobile, elastic-hard, non-tender mass. Magnetic resonance imaging detected an intra-articular soft tissue mass with iso-signal intensity relative to skeletal muscle on T1-weighted sequences and heterogeneous high signal intensity on T2-weighted sequences. Contrast-enhanced fat-suppressed T1-weighted sequences demonstrated strong peripheral enhancement of the mass. An arthroscopic excision of the mass was performed. Histologically, the tumor was composed of spindle- or oval-shaped cells in a fibromyxoid stroma with a prominent vascular pattern. Immunohistochemically, the tumor cells were diffusely positive for vimentin and CD163 and focally positive for CD68, desmin and estrogen receptor. Based on these findings, the tumor was diagnosed as an AFST. The patient had no evidence of local recurrence within 9 months of follow-up. To the best of our knowledge, this is the first case of intra-articular AFST managed successfully with arthroscopic excision.
- Published
- 2017
- Full Text
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16. Role of anion exchange transporter PAT1 (SLC26A6) in intestinal absorption of organic anions.
- Author
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Nozawa T, Sugiura S, Hashino Y, Tsuji A, and Tamai I
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- Amino Acid Transport Systems pharmacokinetics, Animals, Anion Transport Proteins, Antiporters pharmacokinetics, Biological Transport, Active, Formates metabolism, Intestinal Absorption, Mice, Oxalates metabolism, Sulfate Transporters, Symporters, Amino Acid Transport Systems physiology, Antiporters physiology, Organic Anion Transporters physiology
- Abstract
Mouse PAT1 (putative anion transporter, CEFX, slc26a6), an orthologue of human SLC26A6, was recently identified at the intestinal brush-border membrane and shown to transport organic anions such as formate and oxalate, as well as inorganic ions. In this study, we conducted functional characterization of the uptake of formate by HEK293 cells transfected with PAT1. The uptake of formate by PAT1 was increased in the presence of an outwardly-directed Cl gradient, whereas Na had no effect, and the uptake was independent of pH. The Km of PAT1 for formate was 3.75 mM. Various organic acids exhibited a cis-inhibitory effect on the uptake of formate by PAT1. Furthermore, the uptake was increased by preloading with -lactate, nicotinate, valproate and short-and medium-chain fatty acids, showing a trans-stimulatory effect. Thus, it was suggested that PAT1 transports organic acids as well as inorganic anions, demonstrating that it is involved in the intestinal absorption of anionic organic weak acids in the small intestine.
- Published
- 2004
- Full Text
- View/download PDF
17. Effect of diflubenzuron on incorporation of [3H]-N-acetylglucosamine ([3H]NAGA) into chitin in the intact integument from the newly molted American cockroach Periplaneta americana.
- Author
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Nakagawa Y, Matsumura F, and Hashino Y
- Subjects
- Animals, Anti-Bacterial Agents pharmacology, Membrane Lipids metabolism, Mitochondria drug effects, Mitochondria metabolism, Phospholipids metabolism, Protease Inhibitors pharmacology, Protein Kinase Inhibitors, Protein Kinases metabolism, Protein Synthesis Inhibitors pharmacology, Pyrimidine Nucleosides pharmacology, Viral Matrix Proteins metabolism, Chitin biosynthesis, Diflubenzuron pharmacology, Periplaneta metabolism, Uridine Diphosphate N-Acetylglucosamine metabolism
- Abstract
1. Diflubenzuron and polyoxin D clearly inhibited the incorporation of [3H]-N-acetylglucosamine ([3H]NAGA) into chitin in the isolated integument from newly molted American cockroaches under the experimental condition. 2. Upon homogenization, or tissue slicing, such an inhibitory effect of diflubenzuron on chitin synthesis totally disappeared, while that of polyoxin D did not. 3. Mitochondrial poisons (oligomycin and FCCP), protein phosphorylation modulations (8-Br-cAMP, Na3VO4 and MnCl2), potassium ionophores (valinomycin), and calmodulin inhibitor (trifluoperazine) clearly inhibited [3H]NAGA incorporation. 4. Phospholipase A2 and calcium ion significantly enhanced the [3H]NAGA incorporation.
- Published
- 1993
- Full Text
- View/download PDF
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