25 results on '"Hasan Herken"'
Search Results
2. The impact of synapsin III gene on the neurometabolite level alterations after single-dose methylphenidate in attention-deficit hyperactivity disorder patients
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Mehmet Emin Erdal, Ahmet Buber, Ömer Başay, Yilmaz Kiroglu, Şenay Görücü Yılmaz, Huseyin Alacam, Hasan Herken, Önder Öztürk, and Burge Kabukcu Basay
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creatinine blood level ,methylphenidate ,Striatum ,chemistry.chemical_compound ,0302 clinical medicine ,N-acetylaspartate ,Adult ADHD ,single nucleotide polymorphism ,dose response ,Choline ,Original Research ,dorsolateral prefrontal cortex ,Methylphenidate ,adult ,drug effect ,creatinine ,single drug dose ,synapsin III gene ,medicine.anatomical_structure ,female ,Analysis of variance ,medicine.drug ,marker gene ,medicine.medical_specialty ,Neuropsychiatric Disease and Treatment ,Genotype ,cerebellum ,metabolite ,attention deficit disorder ,Creatine ,Article ,03 medical and health sciences ,male ,choline ,Internal medicine ,mental disorders ,Magnetic resonance spectroscopy ,medicine ,Attention deficit hyperactivity disorder ,human ,Psychiatry ,corpus striatum ,Anterior cingulate cortex ,anterior cingulate ,n acetylaspartic acid ,business.industry ,medicine.disease ,DNA isolation ,major clinical study ,030227 psychiatry ,Dorsolateral prefrontal cortex ,Endocrinology ,chemistry ,nervous system ,business ,030217 neurology & neurosurgery - Abstract
Ömer BaÅay,1 Burge Kabukcu Basay,1 Huseyin Alacam,2 Onder Ozturk,1 Ahmet Buber,1 Senay Gorucu Yilmaz,3 Yılmaz KıroÄlu,4 Mehmet Emin Erdal,5 Hasan Herken2 1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, 2Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, 3Department of Nutrition and Dietetics, Faculty of Health Sciences, Gaziantep University, Gaziantep, 4Department of Radiology, School of Medicine, Pamukkale University, Denizli, 5Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin,Turkey Objective: To investigate the neurometabolite level changes according to synapsin III gene rs133945G>A and rs133946C>G polymorphisms by using magnetic resonance spectroscopy (MRS) in patients with attention-deficit hyperactivity disorder (ADHD).Methods: Fifty-seven adults diagnosed with ADHD were recruited for the study. The participants were examined by single-voxel 1H MRS when medication naïve and 30minutes after oral administration of 10mg methylphenidate (Mph). Those who had been on a stimulant discontinued the medication 48hours before MRS imaging. Spectra were taken from the anterior cingulate cortex, dorsolateral prefrontal cortex, striatum, and cerebellum, and N-acetylaspartate (NAA), choline, and creatine levels were examined. For genotyping of the synapsin III gene polymorphisms, DNA was isolated from peripheral blood leukocytes. The effects of age, sex, and ADHD subtypes were controlled in the analyses.Results: After a single dose of Mph, choline levels increased significantly in the striatum of rs133945G>A polymorphism-GG genotypes (P=0.020) and NAA levels rose in the anterior cingulate cortex of rs133946C>G polymorphism-CG genotypes (P=0.014). Both rs133945G>Aand rs133946C>G polymorphisms were found to statistically significantly affect the alteration of NAA levels in response to Mph in dorsolateral prefrontal cortex with two-way repeated measure of analysis of variance. Post hoc comparisons revealed a significant difference between CG and GG genotypes of rs133946C>G polymorphisms after Bonferroni adjustment (P=0.016).Conclusion: Synapsin III gene polymorphisms may be affecting the changes in neurometabolite levels in response to Mph in adult ADHD patients. Future studies are needed to confirm our findings. Keywords: adult ADHD, magnetic resonance spectroscopy, N-acetylaspartate, genotype
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- 2016
3. Effect of adult attention deficit hyperactivity symptoms on smoking cessation
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Ceyhan Balcı ŞENGÜL, Cem ŞENGÜL, GÜLŞEN ÜNLÜ, Ahmet BÜBER, Kamuran KARAKÜLAH, and Hasan HERKEN
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mental disorders ,Psikiyatri - Abstract
Objective: Nicotine addiction is the most prevalent addiction type all over the world and attention deficit hyperactivity disorder (ADHD) is an important factor associated with nicotine addiction. Primary aim of this study was to evaluate the effect of ADHD symptoms on smoking cessation. Methods: Smokers who had admitted to the smoking cessation center were evaluated with using Wender Utah and Fagerstorm Scales at the beginning of study and for the success of smoking cessation at the end of 6 months. Results: Of the 353 smokers enrolled to the study, 99 individuals had a score of 36 or higher on Wender Utah scale (ADHD symptoms group). Of these 99 patients with ADHD symptoms, 11 (11.1%) and of the 254 non-ADHD symptoms group, 68 (26.8%) had quitted smoking after a period of six months. Logistic regression analysis revealed that having ADHD symptoms predicted failure of smoking cessation (adjusted odds ratios 2.12, 95% confidence interval 1.02-4.40) after controlling for sociodemographic and smoking-related variables. Conclusions: ADHD symptoms may be an important factor affecting smoking cessation. Examining these symptoms in problematic nicotine addicts might help treatment outcome.
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- 2016
4. Practice of Acute and Maintenance Electroconvulsive Therapy in the Psychiatric Clinic of a University Hospital from Turkey: Between 2007 and 2013
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Hasan Herken, Melike Ceyhan Balcı Şengül, Cem Şengül, Ayse Nur Inci Kenar, Ezgi Hanci, and İbrahim Sendur
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demography ,observation ,Hospitalized patients ,medicine.medical_treatment ,electroconvulsive therapy ,medical record review ,Turkey (republic) ,haloperidol ,Behavioral Neuroscience ,0302 clinical medicine ,Electroconvulsive therapy ,venlafaxine ,obsessive compulsive disorder ,Medicine ,Pharmacology (medical) ,psychosis ,Medical diagnosis ,chlorpromazine ,clomipramine ,bipolar depression ,clozapine ,sertraline ,Medical record ,adult ,duloxetine ,University hospital ,Psychiatry and Mental health ,hospital patient ,female ,Original Article ,paliperidone ,fluvoxamine ,paroxetine ,hospitalization ,medicine.medical_specialty ,olanzapine ,maintenance therapy ,mental hospital ,mood disorder ,university hospital ,behavioral disciplines and activities ,Article ,03 medical and health sciences ,milnacipran ,male ,Obsessive compulsive ,mental disorders ,controlled study ,human ,Psychiatry ,mirtazapine ,risperidone ,controlled clinical trial ,business.industry ,practice guideline ,Significant difference ,fluoxetine ,bipolar mania ,quetiapine ,Electroconvulsive therapy indications ,major clinical study ,schizoaffective psychosis ,030227 psychiatry ,social status ,schizophrenia ,age ,Male patient ,flupentixol ,catatonia ,disease duration ,business ,major depression ,Maintenance electroconvulsive therapy ,030217 neurology & neurosurgery - Abstract
Objective: Electroconvulsive therapy (ECT) can be given as the form of acute, continuation or maintenance ECT according to the process of administration. We report our 7 years' observation with acute and maintenance ECT in a university hospital in Turkey. Methods: The medical records of the hospitalized patients treated with acute or maintenance ECT between the years 2007 and 2013 was retrospectively analyzed. The sociodemographic characteristics, diagnosis, data of ECT and the co-administered psychotropic drugs were recorded. The frequency of ECT was calculated by identifying the total number of the hospitalized patients during the study period from the hospital records. Results: A total number of 1,432 female and 1,141 male patients hospitalized in a period of 7 years, with a total number of 111 patients treated with ECT. The ratio of ECT was 4%, maintenance/acute ECT 11%. For acute ECT, affective disorders (65.3%) and psychotic disorders (21.6%) were among the leading diagnoses. Maintenance ECT, the diagnosis was; 6 affective disorders, 4 psychotic disorders and 1 obsessive compulsive disorder. There was a significant difference between the patients receiving acute and maintenance ECT in terms of age, duration of illness, and number of previous hospitalizations and ECTs. Conclusion: The percentage of patients treated with acute ECT is lower in our institution than that in many other institutions from our country. Acute and maintenance ECT should be considered as an important treatment option particularly for patients with long disease duration, a high number of hospitalizations and a history of benefiting from previous ECTs. Copyright © 2016, Korean College of Neuropsychopharmacology.
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- 2016
5. Increased urinary 6-hydroxymelatoninsulfate levels in attention deficit hyperactivity disorder diagnosed children and adolescent
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Burcu Çakaloz, Gülşen Ünlü, Hayrani Eren Bostancı, Hülya Aybek, Hasan Herken, Yetis Isildar, Ahmet Buber, and [Buber, Ahmet -- Unlu, Gulsen] Pamukkale Univ, Fac Med, Dept Child & Adolescent Psychiat, Denizli, Turkey -- [Cakaloz, Burcu] Behcet Uz Childrens Hosp, Dept Child & Adolescent Psychiat, Izmir, Turkey -- [Isildar, Yetis] Sami Ulus Childrens Hosp, Dept Child & Adolescent Psychiat, Ankara, Turkey -- [Bostanci, Hayrani Eren] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Sivas, Turkey -- [Aybek, Hulya] Pamukkale Univ, Fac Med, Dept Biochem, Denizli, Turkey -- [Herken, Hasan] Pamukkale Univ, Fac Med, Dept Psychiat, Denizli, Turkey
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circadian rhythm ,Male ,medicine.medical_specialty ,Adolescent ,Urinary system ,attention deficit disorder ,melatonin ,Urine ,Gastroenterology ,6-sulfatoxymelatonin ,Excretion ,Melatonin ,Attention deficit hyperactivity disorder ,03 medical and health sciences ,0302 clinical medicine ,analogs and derivatives ,Internal medicine ,medicine ,Humans ,Circadian rhythm ,human ,child ,General Neuroscience ,Case-control study ,case control study ,medicine.disease ,Pathophysiology ,urine ,030227 psychiatry ,6-hydroxymelatoninsulfate ,Endocrinology ,female ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Psychology ,030217 neurology & neurosurgery ,medicine.drug - Abstract
WOS: 000373539400033, PubMed ID: 26879834, There are some studies in attention deficit hyperactivity disorder (ADHD) which note altered circadian rhythms, suggesting abnormalities in melatonin physiology. In order to better characterize the possible melatonin alteration in ADHD, in this study we aimed to detect daytime, nighttime and 24 h levels of 6-hydroxymelatoninsulfate (6-OH MS) in the patients diagnosed with ADHD. Twenty-seven patients between 6 and 16 years-old, who had been diagnosed initially with ADHD, but without other physical and psychiatric disease history and who had not taken psychotropic pharmacotherapy for six months, plus 28 healthy volunteer controls, were included in the study. Urine samples were collected during the whole 24 h cycle, daytime and nighttime separately to assess the time-dependent excretion of the 6-OH MS, which is the main urine metabolite of melatonin. The Enzyme-Linked Immunosorbent Assay (ELISA) method was used for measuring the urine 6-OH MS level. Daytime (15.4 (8.9-24.8) ng/ml vs 6.9 (2.5-15.9) ng/ml, p = 0.002), nighttime (102.9 (65.3-197.7) ng/ml vs 61.5 (37.2-114.4) ng/ml, p = 0.012) and 24 h (54.1 (34.6-83.9) ng/ml vs 27.3 (14.3-48.9) ng/ml, p =0.000) 6-OH MS levels median (25p-75p) were found to be significantly higher in the ADHD group. After adjustment for age and sex, there was a statistically significant difference between the ADHD group (59.8 +/- 4.9) and control group (33.8 +/- 4.8) in 24-h 6-OH MS levels (F(1, 51) = 13.673, p = .001, partial eta 2 = .211). There was no relationship between 6-OH MS levels and Conners Parent Rating Scale short form subscale scores for the ADHD group. These findings indicate that melatonin production is increased in ADHD cases. Further research is needed to determine and thereby understand the mechanisms underlying the higher melatonin production, to assess the impact of altered melatonin on the pathophysiology of ADHD. (C) 2016 Elsevier Ireland Ltd. All rights reserved., Pamukkale University Scientific Research Projects Coordination Unit [TPF007], This research was supported by the Pamukkale University Scientific Research Projects Coordination Unit (TPF007). We thank Russel J. Reiter for his guidance from the beginning of the study.
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- 2016
6. White matter alterations related to attention-deficit hyperactivity disorder and COMT val158met polymorphism: Children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)
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Önder Öztürk, Ömer Başay, Cengizhan Acikel, Mehmet Emin Erdal, Ahmet Buber, Hasan Herken, Huseyin Alacam, Kadir Agladioglu, Eyüp Sabri Ercan, Serkan Suren, Özlem İzci Ay, Burge Kabukcu Basay, and Ege Üniversitesi
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Internal capsule ,genetic association ,brain development ,uncinate fasciculus ,capsula interna ,0302 clinical medicine ,Gyrus ,Polymorphism (computer science) ,Attention deficit ,valine ,Cingulum (brain) ,genetic polymorphism ,Original Research ,child ,cingulate gyrus ,connectome ,diffusion tensor imaging ,unclassified drug ,homozygote ,medicine.anatomical_structure ,female ,white matter ,fractional anisotropy ,RC321-571 ,medicine.medical_specialty ,Neuropsychiatric Disease and Treatment ,Catechol-O-methyltransferase ,sex difference ,attention deficit disorder ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Neuroimaging ,behavioral disciplines and activities ,Article ,White matter ,03 medical and health sciences ,male ,corona radiata (brain) ,Internal medicine ,mental disorders ,Fractional anisotropy ,medicine ,Attention deficit hyperactivity disorder ,controlled study ,human ,RC346-429 ,methionine ,Catechol-O-methyl transferase ,business.industry ,medicine.disease ,major clinical study ,Hyperactivity ,030227 psychiatry ,thalamus posterior nucleus ,Endocrinology ,catechol methyltransferase ,age ,adolescent ,Neurology. Diseases of the nervous system ,COMT gene ,intelligence quotient ,business ,030217 neurology & neurosurgery - Abstract
WOS: 000374501400001, PubMed ID: 27143897, Introduction: In this article, the COMT gene val(158)met polymorphism and attention-deficit hyperactivity disorder (ADHD)-related differences in diffusion-tensor-imaging-measured white matter (WM) structure in children with ADHD and controls were investigated. Patients and methods: A total of 71 children diagnosed with ADHD and 24 controls aged 8-15 years were recruited. Using diffusion tensor imaging, COMT polymorphism and ADHD-related WM alterations were investigated, and any interaction effect between the COMT polymorphism and ADHD was also examined. The effects of age, sex, and estimated total IQ were controlled by multivariate analysis of covariance (MANCOVA). Results: First, an interaction between the COMT val(158)met polymorphism and ADHD in the right (R) cingulum (cingulate gyrus) (CGC) was found. According to this, valine (val) homozygote ADHD-diagnosed children had significantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) in the R-CGC than ADHD-diagnosed methionine (met) carriers, and val homozygote controls had higher FA and lower RD in the R-CGC than val homozygote ADHD patients. Second, met carriers had higher FA and axial diffusivity in the left (L)-uncinate fasciculus and lower RD in the L-posterior corona radiata and L-posterior thalamic radiation (include optic radiation) than the val homozygotes, independent of ADHD diagnosis. Third, children with ADHD had lower FA in the L-CGC and R-retrolenticular part of the internal capsule than the controls, independent of the COMT polymorphism. Conclusion: Significant differences reported here may be evidence that the COMT gene val(158)met polymorphism variants, as well as ADHD, could affect brain development. ADHD and the COMT polymorphism might be interactively affecting WM development in the R-CGC to alter the WM connectivity in children with val homozygote ADHD.
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- 2016
7. Association of adult attention deficit hyperactivity disorder subtypes and response to methylphenidate HCL treatment: A magnetic resonance spectroscopy study
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Yilmaz Kiroglu, Ayse Nur Inci Kenar, Hasan Herken, and G.A. Unal
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Male ,Magnetic Resonance Spectroscopy ,Subtype ,methylphenidate ,Striatum ,Choline ,chemistry.chemical_compound ,N-acetylaspartate ,analogs and derivatives ,Adult ADHD ,Cerebellum ,middle aged ,central stimulant agent ,Prefrontal cortex ,dorsolateral prefrontal cortex ,prefrontal cortex ,Methylphenidate ,General Neuroscience ,adult ,cingulate gyrus ,drug effect ,medicine.anatomical_structure ,female ,priority journal ,nuclear magnetic resonance scanner ,young adult ,Psychology ,medicine.drug ,medicine.medical_specialty ,Adolescent ,metabolite ,attention deficit disorder ,Creatine ,Gyrus Cinguli ,Article ,Internal medicine ,mental disorders ,medicine ,Attention deficit hyperactivity disorder ,Humans ,human ,corpus striatum ,Anterior cingulate cortex ,nuclear magnetic resonance spectroscopy ,anterior cingulate ,Aspartic Acid ,n acetylaspartic acid ,treatment response ,medicine.disease ,major clinical study ,Dorsolateral prefrontal cortex ,Endocrinology ,chemistry ,Attention Deficit Disorder with Hyperactivity ,Central Nervous System Stimulants ,Neuroscience ,human activities ,metabolism - Abstract
The effects of methylphenidate (MPH) treatment on N-acetyl aspartate (NAA), choline and creatine are being examined in individuals with different subtypes of attention deficit hyperactivity disorder (ADHD). Sixty ADHD subjects were included into the study aging between 18 and 60 years. Levels of NAA, creatine and choline in anterior cingulate cortex, cerebellum, striatum and dorsolateral prefrontal cortex were measured with magnetic resonance spectroscopy. Then, 10 mg oral MPH was given to the subjects and the same metabolite levels were measured after an interval of 30 min. Distribution of the patients according to the ADHD subtypes was as follows: 21 of them (35.0%) were in the inattentive type, 11 of them (18.3%) were in the hyperactive type and 28 of them were (46.7%) in the combined type. Changes of brain metabolite levels after MPH were found not to be statistically significantly different between the subtypes. The increase of choline levels after MPH compared to the levels of choline before MPH in striatum in the combined type patients were statistically significant. No clear association was found between ADHD subtypes and changes of brain metabolites with use of MPH in adult ADHD. © 2015 Elsevier Ireland Ltd.
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- 2015
8. Association of SNAP-25 Gene Ddel and Mnll Polymorphisms with Adult Attention Deficit Hyperactivity Disorder
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G.A. Unal, Ayse Nur Inci Kenar, Mustafa Ertan Ay, Hasan Herken, Tuba Gökdoğan Edgünlü, Mehmet Emin Erdal, Burcu Çakaloz, Cem Şengül, Erinç Yücel, MÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, and Edgünlü, Tuba
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Oncology ,medicine.medical_specialty ,Turkish population ,genetic association ,Vesicle docking ,genotype ,polymerase chain reaction ,attention deficit disorder ,SNAP-25 gene ,genetic analysis ,Adult ADD ADHD DSM IV Based Diagnostic Screening and Rating Scale ,gene frequency ,Bioinformatics ,behavioral disciplines and activities ,Article ,assessment of humans ,male ,Genetic ,Polymorphism (computer science) ,Rating scale ,Internal medicine ,Genotype ,mental disorders ,medicine ,Attention deficit hyperactivity disorder ,ADHD ,controlled study ,human ,Gene ,Biological Psychiatry ,restriction fragment length polymorphism ,business.industry ,adult ,Snap ,medicine.disease ,DNA isolation ,major clinical study ,Wender Utah Rating Scale ,Psychiatry and Mental health ,stomatognathic diseases ,female ,synaptosomal associated protein 25 ,DNA polymorphism ,Original Article ,disease severity ,business ,SNAP-25 Gene - Abstract
Objective The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperactivity disorder (ADHD). We investigated whether these SNAP-25 polymorphisms (MnlI T/G and DdelI T/C) were also associated with ADHD in the Turkish population. Methods: Our study comprised unrelated 139 subjects who met DSM-IV criteria for ADHD and 73 controls and all were of Turkish origin. Genetic analyses were performed and patients were evaluated with Wender-Utah Rating Scale and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale. Results: SNAP-25 DdelI polymorphism was not associated with ADHD but there was a statistically significant difference between ADHD patients and controls for SNAP-25 MnlI polymorphism. For SNAP-25 MnlI polymorphism patients with G/G genotype of the SNAP-25 gene MnlI polymorphism had higher Wender-Utah scores and higher scores in the 1st and 3rd parts of adult ADD/ADHD Scale. Conclusion: We detected a significant association of the MnlI polymorphism in our ADHD sample which was similar to previous findings. Our study also revealed that SNAP-25 MnlI polymorphism was also associated with symptom severity of ADHD. This study is also, the first report on the association of SNAP-25 with ADHD in the Turkish population. © 2014 Korean Neuropsychiatric Association.
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- 2014
9. Association of VAMP-2 and syntaxin 1A genes with adult attention deficit hyperactivity disorder
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Mehmet Emin Erdal, Özlem İzci Ay, Aẙe Nur Inci Kenar, and Hasan Herken
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Syntaxin 1A ,genetic association ,intron ,genotype ,polymerase chain reaction ,attention deficit disorder ,genetic analysis ,gene frequency ,Genetic analysis ,Structured Clinical Interview for DSM Disorders ,synaptobrevin 2 gene ,Genetic ,male ,Dopamine ,Polymorphism (computer science) ,mental disorders ,middle aged ,medicine ,Attention deficit hyperactivity disorder ,ADHD ,controlled study ,human ,gene ,Gene ,Biological Psychiatry ,restriction fragment length polymorphism ,Genetics ,adult ,Dopaminergic ,Intron ,allele ,article ,Synaptobrevin 2 ,genotype environment interaction ,syntaxin 1A gene ,medicine.disease ,VAMP-2 ,major clinical study ,Psychiatry and Mental health ,dopaminergic system ,female ,DNA polymorphism ,Etiology ,young adult ,Original Article ,Psychology ,Neuroscience ,medicine.drug - Abstract
Objective The etiology of attention deficit hyperactivity disorder (ADHD) has not been entirely clarified yet. Structural and metabolic differences at the prefrontal striatal cerebellary system and the interaction of gene and environment are the main factors that thought to play roles in the etiology. Genetic investigations are performed especially about the dopamine pathways and receptors. In this study; it was aimed to investigate the association of the synaptobrevin-2 (VAMP-2) gene Ins/Del polymorphism and syntaxin 1A gene intron 7 polymorphism, which take place in encoding presynaptic protein, with adult ADHD. Methods One hundred thirty-nine patients, having ADHD aging between 18 and 60 years and 106 healthy people as controls were included into the study. DNA samples were extracted from whole blood and genetic analysis were performed. Results A significant difference was determined between ADHD and VAMP-2 Ins/Del polymorphism and syntaxin 1A intron 7 polymorphism according to the control group. These polymorphisms were found not to be associated with subtypes of ADHD. Conclusion It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD. © 2014 Korean Neuropsychiatric Association.
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- 2014
10. Risk of psychotropic drug interactions in real world settings: A pilot study in patients with schizophrenia and schizoaffective disorder
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Hasan Herken, Filiz Karadag, Melike Ceyhan Balcı Şengül, Cem Şengül, Ozgur Kalkanci, and Kamuran Karakülah
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hypotension ,extrapyramidal symptom ,neuroleptic agent ,zuclopenthixol ,haloperidol ,0302 clinical medicine ,venlafaxine ,neurotoxicity ,Medicine ,Pharmacology (medical) ,citalopram ,chlorpromazine ,risk ,anticholinergic syndrome ,clozapine ,sertraline ,adult ,pilot study ,fluphenazine ,pimozide ,liver toxicity ,Psychiatry and Mental health ,Psychotropic drug ,female ,Schizophrenia ,lithium ,carbamazepine ,lamotrigine ,paliperidone ,fluvoxamine ,Clinical psychology ,paroxetine ,cardiovascular risk ,medicine.medical_specialty ,Schizoaffective disorder ,Drug interaction ,respiration depression ,olanzapine ,ziprasidone ,QT prolongation ,Psychotropic ,psychotropic agent ,bradycardia ,Article ,03 medical and health sciences ,aripiprazole ,DSM-IV ,male ,valproic acid ,unindexed drug ,In patient ,propranolol ,human ,polypharmacy ,Psychiatry ,mirtazapine ,Polypharmacy ,risperidone ,business.industry ,fluoxetine ,tricyclic antidepressant agent ,quetiapine ,medicine.disease ,major clinical study ,schizoaffective psychosis ,030227 psychiatry ,schizophrenia ,amisulpride ,Concomitant ,drug blood level ,flupentixol ,central nervous system depression ,teratogenesis ,business ,030217 neurology & neurosurgery - Abstract
Objective: The rate of polypharmacy is increasing in patients with psychotic disorders. Polypharmacy is defined as the concomitant use of two or more drugs at a time. As most psychotropic medications are metabolized via the cytochrome enzyme system, it is easy to predict that polypharmacy will increase the risk of drug-drug interactions. This study was planned to evaluate the interaction risks of medications used by patients with a diagnosis of schizophrenia and schizoaffective disorder., Method: This study enrolled inpatients and outpatients of 18-65 years of age, diagnosed with schizophrenia or schizoaffective disorder according to the DSM-IV classification, who had been receiving antipsychotics for at least 12 weeks. Co-administration of antipsychotic and other psychotropic drugs for at least 4 weeks was recorded as polypharmacy. The risk of interaction was determined as follows: all medications one patient was using were sent to the internet site https://drugs.com as individual treatment regimens, and interaction information for healthcare specialists was used., Results: The study sample consisted of 240 patients (141 males; 58.8%; 99 females; 41.2%) in total, with the schizophrenia spectrum of diseases (schizophrenia, schizoaffective disorder). One hundred and thirty six (56.6%) patients used only one antipsychotic and 104 (43.4%) patients used 2 or more antipsychotics. The mean number of medications was 2.58±1.22 (min 1-max 6), the mean number of interactions was 1.90±2.04 (min 1-max 10). One hundred and seventy two (71.7%) patients were taking medications with a risk of interaction, with 417 total drug interaction risks. Of the interaction risks, 87.8% (total number 366) were at a moderate level. Approximately one quarter of the patients (n=42, 24.4%) were using medications with a major risk, and two patients (1.2%) were taking drugs with a minor risk of interaction. Among probable outcomes of drug interactions, the first 3 places were occupied by a risk of anticholinergic side effects, a risk of CNS or respiratory depression and a risk of QT prolongation., Conclusion: The present study reports that an important percentage of patients are exposed to drug-drug interactions with ever-increasing use of multiple medications in the schizophrenia spectrum of diseases, and among these interactions, most major risks were cardiovascular risks, especially QT prolongation. Prospective studies with larger numbers of patients are needed in this area. © 2014, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved.
- Published
- 2014
11. Association of synapsin III gene with adult attention deficit hyperactivity disorder
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Mehmet Emin Erdal, Hasan Herken, Tuba Gökdoğan Edgünlü, Ayse Nur Inci Kenar, MÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, and Edgünlü, Tuba
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Male ,genomic DNA ,genetic association ,genotype ,genetic analysis ,Hyperactivity disorder ,Polymorphism (computer science) ,Age of Onset ,comparative study ,Genetics ,Dopaminergic ,allele ,article ,General Medicine ,phosphoprotein ,unclassified drug ,female ,priority journal ,Adult ,attention deficit disorder ,Biology ,gene frequency ,behavioral disciplines and activities ,Polymorphism, Single Nucleotide ,Young Adult ,mental disorders ,medicine ,Attention deficit hyperactivity disorder ,Humans ,controlled study ,Genetic Predisposition to Disease ,human ,Allele ,Molecular Biology ,Gene ,Allele frequency ,Alleles ,Genetic Association Studies ,Case-control study ,Cell Biology ,medicine.disease ,Synapsins ,major clinical study ,DNA polymorphism ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Age of onset ,synapsin III ,adult disease - Abstract
It was aimed to investigate the association of the synapsin III gene -196 G> A and -631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One hundred thirty-nine patients having adult ADHD and 106 controls were included in the study. DNA samples were extracted from whole blood and genetic analyses were performed. A significant difference was determined between ADHD and synapsin III gene -631 C>G polymorphism compared to the control group. No significant difference was determined between ADHD and synapsin III gene -196 G>A polymorphism. These polymorphisms were found not to be associated with subtypes of ADHD. It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
- Published
- 2013
12. The relationship of oxidative metabolism to treatment response in major depression: A biological basis for treatment duration
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Alican Dalkilic, M. Cemal Kaya, Hasan Herken, Yasin Bez, Haluk A. Savaş, Ozcan Erel, Bunyamin Kaptanoglu, Hakim Celik, and Salih Selek
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Treatment duration ,correlation analysis ,Free radicals ,medicine.disease_cause ,Neurobiology ,venlafaxine ,total oxidant status ,oxidative stress ,citalopram ,Depression (differential diagnoses) ,clinical article ,Depression ,General Neuroscience ,adult ,article ,aerobic metabolism ,Psychiatry and Mental health ,female ,priority journal ,Major depressive disorder ,Antidepressant ,disease severity ,Hamilton scale ,Clinical psychology ,medicine.medical_specialty ,Treatment response ,metabolic parameters ,total antioxidant status ,escitalopram ,Total oxidative status ,male ,Internal medicine ,medicine ,In patient ,controlled study ,human ,mirtazapine ,Oxidative metabolism ,treatment duration ,business.industry ,scoring system ,treatment response ,medicine.disease ,Anti-depressants ,Neurology (clinical) ,business ,major depression ,Oxidative stress - Abstract
Background: We aimed to determine the relationship between antidepressant treatment and oxidative metabolism in patients with major depression. Materials and methods: Two groups, the patients diagnosed with depression (N = 21), and healthy controls (N = 40), were enrolled in the study. The patients received naturalistic antidepressant treatment. Serum samples were collected prior to treatment and at the end of the 8 weeks of antidepressant treatment. Those participants in the control group were sampled only once. The total antioxidant status (TAS) and total oxidant status (TOS) were measured and oxidative stress index (OSI) was calculated. Severity of depression in patients was also measured both prior to and after 8 weeks of antidepressant treatment. Results: In terms of TAS, TOS, and OSI there were significant differences between the groups both at the baseline. Baseline and final HAM-D scores of the patient group differed significantly. The baseline TAS, TOS, and OSI levels of patients did not change significantly after antidepressant treatment. The duration of illness was not correlated with baseline serum levels of TAS, TOS, and OSI. Patients who were deemed to be unresponsive to the antidepressant treatment differed significantly from the controls both at the baseline and at the final visit for TAS, TOS, and OSI. Additionally, treatment responsive patients did not show any similar difference in terms of TOS and OSI levels. Discussion: Chronic increase in anti-oxidant and oxidant levels in patients with major depression may be related to the elevation of anti-oxidant defenses that were developed in response to increased oxidative metabolism. © 2011 Elsevier GmbH. All rights reserved.
- Published
- 2012
13. Association among SNAP-25 gene DdeI and MnlI polymorphisms and hemodynamic changes during methylphenidate use: A functional near-infrared spectroscopy study
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Koray Ciftci, Ata Akin, Duygu Şahin Biçer, Ozlem Hekim Bozkurt, Mustafa Ertan Ay, Yanki Yazgan, Hasan Herken, Mehmet Emin Erdal, Kerim Munir, Bedriye Öncü, and Ozgur Oner
- Subjects
Male ,Hemodynamics ,methylphenidate ,hemodynamics ,Genotype ,Developmental and Educational Psychology ,genetic polymorphism ,genetics ,central stimulant agent ,Child ,Spectroscopy, Near-Infrared ,Methylphenidate ,drug effect ,Snap ,allele ,article ,Brain ,Clinical Psychology ,female ,synaptosomal associated protein 25 ,Female ,Psychology ,medicine.drug ,Adult ,medicine.medical_specialty ,Adolescent ,Synaptosomal-Associated Protein 25 ,near infrared spectroscopy ,brain ,attention deficit disorder ,functional neuroimaging ,Article ,vascularization ,Internal medicine ,medicine ,ADHD ,functional near-infrared spectroscopy ,Humans ,human ,Allele ,Gene ,Alleles ,Polymorphism, Genetic ,Functional Neuroimaging ,Endocrinology ,Attention Deficit Disorder with Hyperactivity ,Attention deficit ,SNAP-25 ,Functional near-infrared spectroscopy ,Central Nervous System Stimulants ,Neuroscience - Abstract
Objective: To investigate the interaction of treatment-related hemodynamic changes with genotype status for Synaptosomal associated protein 25 (SNAP-25) gene in participants with attention deficit hyperactivity disorder (ADHD) on and off single dose short-acting methylphenidate treatment with functional near-infrared spectroscopy (fNIRS). Method: A total of 15 right-handed adults and 16 right-handed children with DSM-IV diagnosis of ADHD were evaluated. Ten milligrams of short-acting methylphenidate was administered in a crossover design. Results: Participants with SNAP-25 DdeI T/T genotype had decreased right deoxyhemoglobin ([HHb]) with treatment. SNAP-25 MnlI genotype was also associated with right deoxyhemoglobin ([HbO2]) and [HHb] changes as well as left [HHb] change. When the combinations of these genotypes were taken into account, the participants with [DdeI C/C or T/C and MnlI G/G or T/G] genotype had increased right [HHb] with MPH use whereas the participants with [DdeI T/T and MnlI T/T] or [DdeI T/T and MnlI G/G or T/G] genotypes had decreased right prefrontal [HHb]. Conclusions: These results suggested that SNAP-25 polymorphism might be associated with methylphenidate induced brain hemodynamic changes in ADHD participants. © 2011 SAGE Publications.
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- 2011
14. CYP1A2*1F polymorphism decreases clinical response to clozapine in patients with schizophrenia
- Author
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Cengiz Basoglu, Mesut Cetin, Melih O. Babaoglu, Hakan Balibey, Hasan Herken, Anders Rane, Stefan Lundgren, Umit Yasar, and Atilla Bozkurt
- Subjects
drug megadose ,Scale for the Assessment of Positive Symptom ,medicine.medical_treatment ,genotype ,retrospective study ,CYP1A2 ,cigarette smoking ,Pharmacology ,urologic and male genital diseases ,0302 clinical medicine ,single nucleotide polymorphism ,psychologic test ,cytochrome P450 1A2 1F ,genetic polymorphism ,Pharmacology (medical) ,heterocyclic compounds ,psychosis ,Clozapine ,biology ,adult ,Smoking ,article ,respiratory system ,Scale for the Assessment of Negative Symptom ,unclassified drug ,Psychiatry and Mental health ,female ,wild type ,Psychology ,cytochrome P450 1A2 ,medicine.drug ,drug dose increase ,Treatment response ,gene frequency ,03 medical and health sciences ,male ,medicine ,biochemistry ,Brief Psychiatric Rating Scale ,follow up ,In patient ,human ,Antipsychotic ,treatment duration ,organic chemicals ,Cytochrome P450 ,treatment response ,major clinical study ,030227 psychiatry ,schizophrenia ,enzymes and coenzymes (carbohydrates) ,biology.protein ,030217 neurology & neurosurgery ,psychologic assessment - Abstract
Introduction: Genetic polymorphisms of cytochrome P450 (CYP) may predict the treatment response or occurrence of side effects of antipsychotic drugs. Aim: We studied the association of response to clozapine treatment in schizophrenic patients in relation to polymorphisms in the CYP1A2 gene. Methods: The degree of psychosis of the patients (n=55) was assessed using the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Positive Symptoms (SAPS), the Scale for the Assessment of Negative Symptoms (SANS) and routine biochemistry. The patients were monitored for 18 weeks and the scales were applied before starting the treatment and at the end of the follow up period. Clozapine was used at doses of 200 to 600 mg/day. A positive response was defined as a 20% decrease in pre-and posttreatment scores of one of the BPRS, SANS, or SAPS scores. In addition, 45 patients, who were already on clozapine treatment, were assessed retrospectively. Results: As assessed at the 18th week after start of therapy, lack of response to clozapine treatment was 2.4 fold higher in the patients carrying the CYP1A2*1F*1F genotype (p=0.02) compared to patients carrying at least one wild type allele (i.e. *1/*1 or *1/*1F). Smoking decreased the response rate by about 15% (p=0.014). Conclusion: The results of our study suggest that the CYP1A2*1F/*1F genotype may be a risk factor for lack of response to clozapine treatment in psychotic patients, especially in cigarette smokers.
- Published
- 2011
15. The Association of Olanzapine-Induced Weight Gain with Peroxisome Proliferator-Activated Receptor-gamma 2 Pro12Ala Polymorphism in Patients with Schizophrenia
- Author
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Ömer Barlas, Hasan Herken, Nazan Aydin, Mehmet Emin Erdal, Filiz Karadag, Cem Şengül, and Fulya Akin
- Subjects
Olanzapine ,drug safety ,clinical evaluation ,genetic analysis ,Weight Gain ,Turkey (republic) ,Benzodiazepines ,single nucleotide polymorphism ,Polymorphism (computer science) ,genetic variability ,Alanine ,weight change ,article ,General Medicine ,Middle Aged ,Polycystic ovary ,aged ,female ,priority journal ,Schizophrenia ,medicine.symptom ,diagnostic and statistical manual of mental disorders ,amino acid substitution ,Antipsychotic Agents ,medicine.drug ,Adult ,medicine.medical_specialty ,side effect ,Proline ,olanzapine ,peroxisome proliferator activated receptor gamma 2 ,Biology ,Insulin resistance ,male ,Internal medicine ,Genetics ,medicine ,Humans ,human ,Molecular Biology ,DNA Primers ,treatment duration ,Base Sequence ,Weight change ,Cell Biology ,medicine.disease ,major clinical study ,body mass ,drug efficacy ,schizophrenia ,PPAR gamma ,Endocrinology ,gene expression ,treatment outcome ,Metabolic syndrome ,Weight gain ,rating scale - Abstract
Olanzapine is a second-generation antipsychotic that may cause weight gain and metabolic syndrome in some cases. The peroxisome proliferator-activated receptor (PPAR)-? is an important gene in the progress of type II diabetes and metabolic syndrome. In recent studies the polymorphism of the PPAR-? has been studied in type II diabetes mellitus, polycystic ovary syndrome, and insulin resistance syndrome. It is aimed to evaluate the association between polymorphism of PPAR-? gene and olanzapine-induced weight gain. Our study comprised 95 unrelated subjects who strictly met Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for schizophrenia, and all were of Turkish origin. All patients were evaluated with rating scales, and genetic analyses were performed. We found statistically significant differences between pretreatment and posttreatment body mass index and weight change in Pro12Ala polymorphism of PPAR-?2. Our results suggest that genetic polymorphism of PPAR might be important in olanzapine-induced weight gain and that genetic variance of people might be considered in antipsychotic medication selection. © 2009 Mary Ann Liebert, Inc.
- Published
- 2009
16. A defect in the antioxidant defense system in schizophrenia
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Osman Virit, Abdurrahman Altindag, Mehmet Yumru, Sahabettin Selek, Ozcan Erel, Hasan Herken, Haluk A. Savaş, and Alican Dalkilic
- Subjects
Male ,antioxidant ,neuroleptic agent ,anticonvulsive agent ,blood level ,Antioxidants ,Total antioxidant status ,oxidative stress ,antidepressant agent ,Clinical Global Impression scale ,Young adult ,Schizophrenia ,Total oxidant status ,Oxidative ,Schizophrenia, Paranoid ,Smoking ,article ,Middle Aged ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,female ,priority journal ,disease severity ,Positive and Negative Syndrome Scale ,Psychology ,Clinical psychology ,Antipsychotic Agents ,Adult ,medicine.medical_specialty ,Schizophrenia (object-oriented programming) ,anxiolytic agent ,MEDLINE ,macromolecular substances ,behavioral disciplines and activities ,Young Adult ,mental disorders ,medicine ,Humans ,controlled study ,human ,Psychiatry ,Biological Psychiatry ,Psychiatric Status Rating Scales ,major clinical study ,Oxidative stress index ,cell damage ,schizophrenia ,stress index ,Psychiatric status rating scales ,atypical antipsychotic agent - Abstract
Objectives: Several oxidants and antioxidants have been evaluated in schizophrenia. However, previous studies frequently focused on individual parameters. Determination of the total oxidant and antioxidant status may be more useful. Therefore, we aimed to evaluate both plasma total oxidant status (TOS) and total antioxidant status (TAS) together with the oxidative stress index (OSI) in schizophrenia patients for the first time in the literature. Methods: A total of 60 schizophrenia patients and 40 healthy volunteers were included in the study. The Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-severity scale (CGI-S) were used to evaluate the severity of schizophrenia in the patients. TOS and TAS were measured in plasma and the OSI was calculated for patients and controls. Results: There was no difference between patients and controls with regard to TOS, but the patients’ TAS and OSI were significantly lower and higher, respectively, than those of the controls. No difference was detected between the schizophrenia subtypes or between the patients on typical or atypical antipsychotic medications or a combination of the two with regard to oxidative parameters. There was a weak to moderately significant negative correlation between TAS and total, positive and general psychopathology PANSS scores. Finally, we found a weak to moderately significant negative correlation between the CGI-S score and TOS and between the CGI-S score and TAS. Conclusions: There is a defect in the antioxidant defense system in schizophrenia. Known oxidative stress that causes oxidative cell damage and thus contributes to the pathophysiology of schizophrenia may be mainly related to this defensive defect.
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- 2009
17. Oxidative imbalance in obsessive compulsive disorder patients: A total evaluation of oxidant-antioxidant status
- Author
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Salih Selek, Mahmut Bulut, Ozcan Erel, Hasan Herken, Mehmet Fatih Ceylan, Hakim Celik, and Haluk A. Savaş
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Male ,demography ,Obsessive-Compulsive Disorder ,Antioxidant ,antioxidant ,medicine.medical_treatment ,medicine.disease_cause ,Gastroenterology ,Antioxidants ,Pathogenesis ,Total antioxidant status ,obsessive compulsive disorder ,rank sum test ,oxidative stress ,oxidizing agent ,clinical article ,article ,Venous blood ,biological marker ,Oxidants ,Diagnostic and Statistical Manual of Mental Disorders ,female ,Biological Markers ,Psychology ,Anxiety disorder ,Adult ,medicine.medical_specialty ,Free Radicals ,Oxidative phosphorylation ,Internal medicine ,mental disorders ,medicine ,Humans ,controlled study ,human ,Psychiatry ,Biological Psychiatry ,Pharmacology ,Psychiatric Status Rating Scales ,Oxidant antioxidant ,medicine.disease ,Control Groups ,Oxidative stress index ,Total oxidant status ,Cross-Sectional Studies ,Etiology ,colorimetry ,Oxidative stress ,Biomarkers - Abstract
Objectives: Various psychological, social, genetic, biochemical, factors are to be involved in the etiology of OCD. Some molecules of free radicals are also found to play role in OCD. To the best of our knowledge, there has been no study, regarding the role of free radicals in the pathogenesis of OCD, from a general antioxidant aspect of view. Therefore, in this present cross-sectional study, we aimed to assess whether antioxidant-oxidant status is associated with OCD and can be used or not as a biological marker regarding that disorder. Methods: 37 OCD patients diagnosed according to DSM-IV and as control group forty healthy subjects were included to the study. Venous blood samples were collected once. The total oxidant status, antioxidant status and oxidative stress index of the plasma were measured using a novel automated colorimetric measurement method. Results: There was not a significant difference between only OCD and all patients in all measures (TOS: Z = - 1.453, p = 0.521; TAS: Z = - 0.151, p = 0.880; OSI: Z = - 0.679 p = 0.497). TAS levels were both higher than controls in only OCD groups and all patients (Z = - 5.538, p < 0.001 and Z = - 6.394, p < 0.001 respectively). TOS and OSI of both patient groups were significantly lower than controls (TOS: Z = - 5.131, p < 0.001; OSI: Z = - 5.105, p < 0.001 and TOS: Z = - 5.979, p < 0.001; OSI: Z = - 5.862, p < 0.001). In only OCD group, illness duration was correlated with TOS and OSI (r0 = 0.44, p = 0.023, n = 26 and r0 = 0.44, p = 0.026, n = 26 respectively) but not with TAS. Conclusion: Our study found an overall oxidative imbalance shifted towards antioxidant side in OCD which may be due to either a rebound phenomenon or chronicity of the condition. © 2007 Elsevier Inc. All rights reserved.
- Published
- 2008
18. The A218C polymorphism of tryptophan hydroxylase gene and migraine
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Nurten Erdal, Mustafa Yilmaz, Emin Erdal, Hasan Herken, and Yildirim Bayazit
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Male ,Linkage disequilibrium ,genetic structures ,Tryptophan hydroxylase ,polymerase chain reaction ,Tryptophan Hydroxylase ,Linkage Disequilibrium ,Loss of heterozygosity ,Genotype ,Medicine ,migraine ,restriction fragment length polymorphism ,polymorphism ,tryptophan hydroxylase ,Genetics ,family history ,Homozygote ,article ,General Medicine ,Middle Aged ,female ,priority journal ,Neurology ,Female ,Restriction fragment length polymorphism ,Adult ,medicine.medical_specialty ,Heterozygote ,Serotonin ,endocrine system ,Migraine Disorders ,gene frequency ,Physiology (medical) ,Internal medicine ,heterozygosity ,Humans ,controlled study ,human ,Polymorphism ,Allele ,Allele frequency ,Polymorphism, Genetic ,business.industry ,control group ,major clinical study ,Endocrinology ,DNA polymorphism ,epilepsy ,Surgery ,Neurology (clinical) ,Gene polymorphism ,homozygosity ,business - Abstract
Objective: To determine the significance of the A218C polymorphism of the tryptophan hydroxylase (TPH) gene in migraine. Methods: Fifty-nine migraineurs and 62 healthy controls were included in the study, and polymerase chain reaction - restriction fragment length polymorphism assays were used to determine TPH A218C polymorphism. Results: There was no association between TPH gene polymorphism and gender, family history of migraine and epilepsy, or aura. There was no significant difference between the allele frequencies of both groups (p > 0.05). A significant difference was found between the genotypes of the migraineurs and controls regarding the AA genotype. Homozygosity for the C allele or heterozygosity for the A or C was not associated with the occurrence of migraine (p > 0.05), but homozygosity for the A allele was less frequent in the migraineurs (p = 0.02). Conclusion: Since it is unlikely that TPH polymorphism alters serotonin biosynthesis, its association with migraine may be attributed to linkage disequilibrium with a functional variant within the TPH gene or a nearby gene. (C) 2006 Elsevier Ltd. All rights reserved.
- Published
- 2007
19. Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment
- Author
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Haluk A. Savaş, Mehmet Yumru, Neslihan Cansel, Murat Eren Özen, and Hasan Herken
- Subjects
Male ,Pediatrics ,Movement disorders ,Piperazines ,neurologic examination ,Neuroleptic Malignant Syndrome ,Infusions, Intravenous ,Neurologic Examination ,article ,Neuroleptic malignant syndrome ,Psychiatry and Mental health ,Schizophrenia ,Anesthesia ,Drug Therapy, Combination ,medicine.symptom ,medicine.drug ,Antipsychotic Agents ,Adult ,medicine.medical_specialty ,neuroleptic malignant syndrome ,medicine.drug_class ,olanzapine ,ziprasidone ,Atypical antipsychotic ,Signs and symptoms ,rectum temperature ,Biperiden ,Diagnosis, Differential ,Parkinsonian Disorders ,medicine ,case report ,Humans ,Ziprasidone ,human ,Biological Psychiatry ,diazepam ,Diazepam ,treatment duration ,business.industry ,medicine.disease ,clinical feature ,Treatment ,schizophrenia ,Thiazoles ,treatment outcome ,disease duration ,business ,drug urine level - Abstract
Neuroleptic malignant syndrome (NMS) is the rarest and most serious of the neuroleptic-induced movement disorders. We describe a case of neuroleptic malignant syndrome (NMS) associated with the use of ziprasidone. Although conventional neuroleptics are more frequently associated with NMS, atypical antipsychotic drugs like ziprasidone may also be a cause. The patient is a 24-year-old male with a history of schizophrenia who developed signs and symptoms of NMS after 2 days of treatment with an 80-mg/day dose of orally administrated ziprasidone. This case is the earliest (second day of treatment) NMS due to ziprasidone reported in the literature.
- Published
- 2007
20. Nitric oxide, adenosine deaminase, xanthine oxidase and superoxide dismutase in patients with panic disorder: Alterations by antidepressant treatment
- Author
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Omer Akyol, M. Eren Ozen, Haluk A. Savaş, H. Ramazan Yilmaz, Hamdi Tutkun, Aysun Kalenderoglu, Mukaddes Gulec, and Hasan Herken
- Subjects
Male ,Adenosine ,correlation analysis ,panic ,Treatment response ,Turkey (republic) ,chemistry.chemical_compound ,alprazolam ,Adenosine deaminase ,Pharmacology (medical) ,antidepressant agent ,citalopram ,Xanthine oxidase ,pathophysiology ,statistical significance ,Panic disorder ,biology ,adult ,article ,protein function ,Middle Aged ,superoxide dismutase ,Pathophysiology ,Antidepressive Agents ,enzyme activity ,Psychiatry and Mental health ,female ,Neurology ,priority journal ,Antidepressant ,blood sampling ,fluvoxamine ,diagnostic and statistical manual of mental disorders ,medicine.medical_specialty ,Adolescent ,Nitric Oxide ,Nitric oxide ,Superoxide dismutase ,enzyme blood level ,Internal medicine ,medicine ,spectrophotometry ,Humans ,controlled study ,human ,business.industry ,questionnaire ,Spectrum Analysis ,disease association ,Case-control study ,fluoxetine ,medicine.disease ,major clinical study ,adenosine deaminase ,semi structured interview ,Endocrinology ,chemistry ,protein blood level ,Case-Control Studies ,biology.protein ,serotonin uptake inhibitor ,treatment outcome ,Neurology (clinical) ,prognosis ,business ,rating scale - Abstract
Objective In the present study, we aimed to investigate whether nitric oxide (NO) levels and activities of xanthine oxidase (XO), superoxide dismutase (SOD), and adenosine deaminase (ADA) are associated with Panic disorder (PD) as well as impact of psychopharmacological treatments on NO, SOD, ADA, and XO levels in PD. Method In this study, 32 patients and 20 healthy controls were included. The serum levels of NO, XO, SOD, and ADA were measured in the patients and controls. The patients were treated with antidepressant. Results ADA and XO levels of the patients were significantly higher than the controls. SOD levels of the patients were significantly lower than the controls but the difference was not statistically significant. Although NO levels of the patients were higher than the controls, the difference was not statistically significant. There was no correlation between PAS and the parameters studied (SOD, ADA, XO, and NO) of the patients. After 8 weeks of antidepressant treatment, ADA and SOD activities were increased whereas NO and XO levels decreased significantly. Conclusion ADA, XO activity may have a pathophysiological role in PD, and prognosis of PD. Activity of these enzymes may be used to monitor effects of the antidepressant treatment. Copyright © 2005 John Wiley & Sons, Ltd.
- Published
- 2006
21. T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction
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Yildirim Bayazit, N Mutlu, G Oz, Mehmet Emin Erdal, and Hasan Herken
- Subjects
Adult ,Male ,medicine.medical_specialty ,5 ht2a receptor gene ,Disease ,Biology ,Serotonergic ,Polymerase Chain Reaction ,stomatognathic system ,Internal medicine ,Genotype ,medicine ,Humans ,Receptor, Serotonin, 5-HT2A ,Receptor ,General Dentistry ,Gene ,Alleles ,Chi-Square Distribution ,Polymorphism, Genetic ,Temporomandibular Joint Disorders ,stomatognathic diseases ,Endocrinology ,Otorhinolaryngology ,Etiology ,Female ,Serotonin - Abstract
To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction.Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique.The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P0.05).The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentation of the C/C variant of 5-HT2A receptor gene in temporomandibular dysfunction suggests a possible role of the serotonergic system in this disease, particularly at the receptor level.
- Published
- 2004
22. The possible pathophysiological role of plasma nitric oxide and adrenomedullin in schizophrenia
- Author
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S Salih Zoroǧlu, Hasan Herken, Murat Eren Özen, Muhittin Yürekli, Omer Akyol, Haluk A. Savaş, Cahit Baǧci, M Ilker Doǧru, Ecir Ali Çakmak, Hamdi Tutkun, Efkan Uz, Beyhan Cengiz, Zoroglu, SS, Herken, H, Yurekli, M, Uz, E, Tutkun, H, Savas, HA, Bagci, C, Ozen, ME, Cengiz, B, Cakmak, EA, Dogru, MI, Akyol, O, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, Bağcı, Cahit, and Çakmak, Ecir Ali
- Subjects
Adult ,Male ,medicine.medical_specialty ,Psychosis ,Adolescent ,Nitric Oxide ,Severity of Illness Index ,Nitric oxide ,Adrenomedullin ,chemistry.chemical_compound ,Prognosis of schizophrenia ,Internal medicine ,Brief Psychiatric Rating Scale ,Severity of illness ,medicine ,Humans ,Scale for the Assessment of Negative Symptoms ,Biological Psychiatry ,Brain ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Endocrinology ,chemistry ,Schizophrenia ,Chronic Disease ,Female ,Peptides ,Psychology - Abstract
Evidence is accumulating for a possible role of nitric oxide (NO) in schizophrenia. Adrenomedullin (AM) induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of NO. AM immune reactivity is present in the brain consistent with a role as neurotransmitter. We aimed to examine plasma levels of nitrite (a metabolite of NO) and AM in schizophrenic patients. Eighty-two patients with schizophrenia and 21 healthy control subjects were included in this study. DSM-IV diagnosis of chronic schizophrenia was established on the basis of independent structured clinical interviews and review of records by two qualified psychiatrists which included the Brief Psychiatric Rating Scale (BPRS), The Scale for the Assessment of Negative Symptoms (SANS) and The Scale for the Assessment of Positive Symptoms (SAPS). Total nitrite and AM have been studied in plasma. The mean values of plasma nitrite and AM levels in schizophrenic group were significantly higher than control values, respectively (P=0.03, P
- Published
- 2002
23. Association of MDR1 C3435T polymorphism with bipolar disorder in patients treated with valproic acid.
- Author
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Gunfer Turgut, Erhan Kurt, Gazi Alatas, Raziye Kursunluoglu, Timucin Oral, Sabahat Turgut, and Hasan Herken
- Abstract
Abstract P-glycoprotein (P-gp), an efflux transporter protein, is an ABC transporter encoded by the multidrug resistance 1 gene (MDR1, ABCB1). The common synonymous C3435T polymorphism in exon 26 is reported to associate with lower P-gp functional expression and drug uptake. Many extended pharmacogenomics, functional, and complex disease association studies focused mainly on this polymorphism. We investigated the association of exon 26 C3435T genetic variants of MDR1 gene with susceptibility to bipolar disorder and serum valproic acid concentration. Totally, 104 patients meeting DSM-IV criteria for bipolar disorder and 169 controls were admitted to the study. There was statistically significant difference between the genotypes of bipolar patients (CT 91.2%, TT 6.8%, and CC 2%) and controls (CT 52.7%, TT 26%, CC 21.3%) although their allelic distribution was similar. The serum valproic acid concentrations of the patients with CT, TT and CC genotypes were 72.92 ± 20.55, 80.47 ± 14.01 and 68.29 ± 12.17 μg/ml, respectively, and there was no significant difference between the C3435T genotypes. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
24. Plasma Manganese, Selenium, Zinc, Copper, and Iron Concentrations in Patients with Schizophrenia.
- Author
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Medaim Yanik, Abdurrahim Kocyigit, Hamdi Tutkun, Huseyin Vural, and Hasan Herken
- Subjects
TRACE elements ,METABOLISM ,SELENIUM ,MANGANESE ,COPPER ,ZINC ,AUTOIMMUNE diseases ,MENTAL illness ,SCHIZOPHRENIA ,PEOPLE with schizophrenia - Abstract
A number of essential trace elements play a major role in various metabolic pathways. Selenium (Se), manganese (Mn), copper (Cu), zinc (Zn), and iron (Fe) are essential trace elements that have been studied in many diseases, including autoimmune, neurological, and psychiatric disorders. However, the findings of previous research on the status of trace elements in patients with schizophrenia have been controversial. We studied these elements in patients with a DSM-IV diagnosis of schizophrenia and compared them with sex- and age-matched healthy controls. Plasma Cu concentrations were significantly higher (p < 0.01) and Mn and Fe concentrations were lower (p < 0.05 and p < 0.05, respectively) in schizophrenic patients than in controls. Se and Zn concentrations and protein levels did not differ between patients and healthy controls. These observations suggest that alterations in essential trace elements Mn, Cu, and Fe may play a role in the pathogenesis of schizophrenia. However, findings from trace element levels in schizophrenia show a variety of results that are difficult to interpret. [ABSTRACT FROM AUTHOR]
- Published
- 2004
25. Lack of Association of catechol-O-Methyltransferase Gene Polymorphism in ObsessiveCompulsive Disorder.
- Author
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M. Emin Erdal, Şenel Tot, Kemal Yazıcı, Aylin Yazıcı, Hasan Herken, Pervin Erdem, Ebru Derici, and Handan Çamdeviren
- Subjects
GENETIC polymorphisms ,OBSESSIVE-compulsive disorder ,COMPULSIVE behavior ,MENTAL illness ,NEUROSES - Abstract
The COMT gene has been implicated to be involved in the pathogenesis of obsessivecompulsive disorder (OCD) and various other psychiatric disorders. COMT enzyme activity is governed by a common genetic polymorphism at codon 158 that results in substantial 3- to 4-fold variation in enzymatic activity [a high-activity COMT variant (H) and a low activity variant (L)]. This study evaluates the association between OCD and the COMT gene polymorphism. Fifty-nine OCD patients that were diagnosed according to DSM-IV criteria and 114 healthy control subjects were included in the study. PCR technique was used for molecular analysis. The genotypic pattern of distribution of the COMT gene (H/H, H/L, and L/L genotypes) was not different between the OCD patients and controls. There were no significant differences among the patients with positive family history for OCD, those with negative family history for OCD, and the controls with respect to allele frequencies of the COMT gene polymorphisms. Patients that were homozygous or heterozygous for the L allele had significantly higher insight scores (i.e., poorer insight) on Y-BOCS compared to those homozygous for the H allele. We did not find an association between OCD, family history for OCD, and the COMT gene polymorphism. This study suggests that the COMT gene polymorphism is not directly associated with OCD in our patient group. Depression and Anxiety 18:4145, 2003. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
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