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1. The Urgent Need for Libraries to Reimagine Their Civic Role by Turning Outward.

Author

Harwood, Richard C.

Subjects
*LIBRARIES, *ACADEMIC libraries, *COMMUNITY life
Abstract

Our democracy is in trouble today, and libraries must once again step into the breach and reimagine their civic role in these changing times. But exactly how can each library figure out what role it should play in its community? How can libraries ward off growing demands to be all things to all people? This article lays out a path forward for libraries—not to turn more inward and merely seek survival but to be bolder and braver in embracing their communities by turning outward and playing a vital role in community life. Libraries in all 50 US states are taking this approach. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Author

Trubetskoy, Vassily, Pardiñas, Antonio F., Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey S., Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C., Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L., Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G., Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z., Alptekin, Köksal, Als, Thomas D., Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A., Bass, Nicholas J., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Benyamin, Beben, Bergen, Sarah E., Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Bressan, Rodrigo Affonseca, Bromet, Evelyn J., Bruggeman, Richard, Buckley, Peter F., Buckner, Randy L., Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J., Calkins, Monica E., Carr, Vaughan J., Castle, David, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cohen, David, Consoli, Angèle, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., de Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fañanás, Lourdes, Faraone, Stephen V., Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Giannitelli, Marianna, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., González Peñas, Javier, González-Pinto, Ana, Gopal, Srihari, Gratten, Jacob, Green, Michael F., Greenwood, Tiffany A., Guillin, Olivier, Gülöksüz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutiérrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julià, Antonio, Kähler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kučinskas, Vaidutis, Kučinskiene, Zita Ausrele, Kusumawardhani, Agung, Kuzelova-Ptackova, Hana, Landi, Stefano, Lazzeroni, Laura C., Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Lönnqvist, Jouko, Loughland, Carmel M., Lubinski, Jan, Luykx, Jurjen J., Lynham, Amy, Macek, Jr, Milan, Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mitjans, Marina, Molden, Espen, Molina, Esther, Molto, María Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadić, Igor, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Nuechterlein, Keith H., O’Brien, Niamh Louise, O’Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Papadimitriou, George N., Parellada, Mara, Paunio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietiläinen, Olli, Pimm, Jonathan, Porteous, David, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veikko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Siever, Larry J., Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Söderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes A., Stögmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Strengman, Eric, Stroup, T. Scott, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Ta, Thi Minh Tam, Takahashi, Atsushi, Terao, Chikashi, Thibaut, Florence, Toncheva, Draga, Tooney, Paul A., Torretta, Silvia, Tosato, Sarah, Tura, Gian Battista, Turetsky, Bruce I., Üçok, Alp, Vaaler, Arne, van Amelsvoort, Therese, van Winkel, Ruud, Veijola, Juha, Waddington, John, Walter, Henrik, Waterreus, Anna, Webb, Bradley T., Weiser, Mark, Williams, Nigel M., Witt, Stephanie H., Wormley, Brandon K., Wu, Jing Qin, Xu, Zhida, Yolken, Robert, Zai, Clement C., Zhou, Wei, Zhu, Feng, Zimprich, Fritz, Atbaşoğlu, Eşref Cem, Ayub, Muhammad, Benner, Christian, Bertolino, Alessandro, Black, Donald W., Bray, Nicholas J., Breen, Gerome, Buccola, Nancy G., Byerley, William F., Chen, Wei J., Cloninger, C. Robert, Crespo-Facorro, Benedicto, Donohoe, Gary, Freedman, Robert, Galletly, Cherrie, Gandal, Michael J., Gennarelli, Massimo, Hougaard, David M., Hwu, Hai-Gwo, Jablensky, Assen V., McCarroll, Steven A., Moran, Jennifer L., Mors, Ole, Mortensen, Preben B., Müller-Myhsok, Bertram, Neil, Amanda L., Nordentoft, Merete, Pato, Michele T., Petryshen, Tracey L., Pirinen, Matti, Pulver, Ann E., Schulze, Thomas G., Silverman, Jeremy M., Smoller, Jordan W., Stahl, Eli A., Tsuang, Debby W., Vilella, Elisabet, Wang, Shi-Heng, Xu, Shuhua, Adolfsson, Rolf, Arango, Celso, Baune, Bernhard T., Belangero, Sintia Iole, Børglum, Anders D., Braff, David, Bramon, Elvira, Buxbaum, Joseph D., Campion, Dominique, Cervilla, Jorge A., Cichon, Sven, Collier, David A., Corvin, Aiden, Curtis, David, Forti, Marta Di, Domenici, Enrico, Ehrenreich, Hannelore, Escott-Price, Valentina, Esko, Tõnu, Fanous, Ayman H., Gareeva, Anna, Gawlik, Micha, Gejman, Pablo V., Gill, Michael, Glatt, Stephen J., Golimbet, Vera, Hong, Kyung Sue, Hultman, Christina M., Hyman, Steven E., Iwata, Nakao, Jönsson, Erik G., Kahn, René S., Kennedy, James L., Khusnutdinova, Elza, Kirov, George, Knowles, James A., Krebs, Marie-Odile, Laurent-Levinson, Claudine, Lee, Jimmy, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., Malhotra, Dheeraj, McIntosh, Andrew, McQuillin, Andrew, Menezes, Paulo R., Morgan, Vera A., Morris, Derek W., Mowry, Bryan J., Murray, Robin M., Nimgaonkar, Vishwajit, Nöthen, Markus M., Ophoff, Roel A., Paciga, Sara A., Palotie, Aarno, Pato, Carlos N., Qin, Shengying, Rietschel, Marcella, Riley, Brien P., Rivera, Margarita, Rujescu, Dan, Saka, Meram C., Sanders, Alan R., Schwab, Sibylle G., Serretti, Alessandro, Sham, Pak C., Shi, Yongyong, St Clair, David, Stefánsson, Hreinn, Stefansson, Kari, Tsuang, Ming T., van Os, Jim, Vawter, Marquis P., Weinberger, Daniel R., Werge, Thomas, Wildenauer, Dieter B., Yu, Xin, Yue, Weihua, Holmans, Peter A., Pocklington, Andrew J., Roussos, Panos, Vassos, Evangelos, Verhage, Matthijs, Visscher, Peter M., Yang, Jian, Posthuma, Danielle, Andreassen, Ole A., Kendler, Kenneth S., Owen, Michael J., Wray, Naomi R., Daly, Mark J., Huang, Hailiang, Neale, Benjamin M., Sullivan, Patrick F., Ripke, Stephan, Walters, James T. R., and O’Donovan, Michael C.

Published
2022
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4. Measuring the stability of fundamental constants with a network of clocks

Author

Barontini, G., Blackburn, L., Boyer, V., Butuc-Mayer, F., Calmet, X., Crespo López-Urrutia, J. R., Curtis, E. A., Darquié, B., Dunningham, J., Fitch, N. J., Forgan, E. M., Georgiou, K., Gill, P., Godun, R. M., Goldwin, J., Guarrera, V., Harwood, A. C., Hill, I. R., Hendricks, R. J., Jeong, M., Johnson, M. Y. H., Keller, M., Kozhiparambil Sajith, L. P., Kuipers, F., Margolis, H. S., Mayo, C., Newman, P., Parsons, A. O., Prokhorov, L., Robertson, B. I., Rodewald, J., Safronova, M. S., Sauer, B. E., Schioppo, M., Sherrill, N., Stadnik, Y. V., Szymaniec, K., Tarbutt, M. R., Thompson, R. C., Tofful, A., Tunesi, J., Vecchio, A., Wang, Y., and Worm, S.

Published
2022
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5. Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease

Author

DeMichele-Sweet, Mary Ann A., Klei, Lambertus, Creese, Byron, Harwood, Janet C., Weamer, Elise A., McClain, Lora, Sims, Rebecca, Hernandez, Isabel, Moreno-Grau, Sonia, Tárraga, Lluís, Boada, Mercè, Alarcón-Martín, Emilio, Valero, Sergi, Liu, Yushi, Hooli, Basavaraj, Aarsland, Dag, Selbaek, Geir, Bergh, Sverre, Rongve, Arvid, Saltvedt, Ingvild, Skjellegrind, Håvard K., Engdahl, Bo, Stordal, Eystein, Andreassen, Ole A., Djurovic, Srdjan, Athanasiu, Lavinia, Seripa, Davide, Borroni, Barbara, Albani, Diego, Forloni, Gianluigi, Mecocci, Patrizia, Serretti, Alessandro, De Ronchi, Diana, Politis, Antonis, Williams, Julie, Mayeux, Richard, Foroud, Tatiana, Ruiz, Agustin, Ballard, Clive, Holmans, Peter, Lopez, Oscar L., Kamboh, M. Ilyas, Devlin, Bernie, and Sweet, Robert A.

Published
2021
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7. Defining the chromatin structure of the human genome using size-selected nucleosome mapping

Author

Harwood, Janet C.

Subjects
572.8, QH301 Biology
Abstract

The work in this thesis examines genome-wide and local changes in the patterns of nucleosome positioning throughout the human genome. Nucleosomes are the fundamental repeating unit of chromatin. Their properties and positioning in the genome dictate whether and how proteins involved in gene regulation can access DNA. Nucleosomes are dynamic; their positions can vary considerably at some loci from one cell type to another. Chromatin remodelling complexes can change the structure and the positions of nucleosomes. Their mis-regulation leads to congenital defects affecting pre-natal and early childhood development and is associated with neuro-psychiatric disorders. As mutations in genes that encode chromatin remodelling proteins are associated with human mental health disorders, the work in this thesis focusses on changes that occur in chromatin structure during early neural development. I have used MNase-seq data to construct genome-wide, high-resolution chromatin particle positioning maps from undifferentiated human induced pluripotent stem cells (hiPSC) and following differentiation to the neuro-progenitor cell (NPC) stage. These maps reveal that a small proportion of the pluripotent genome possesses well-positioned nucleosomes, the number of which increases approximately 8-fold during neural cell development. This is accompanied by changes in the distribution and localisation of nucleosomes between iPS and NPC cells. Differences in nucleosome positioning during neural cell differentiation were investigated at regulatory regions. Loss and gain of positioned nucleosomes at TSS of pluripotent and neural-specific genes was detected and correlated with gene expression. In addition I investigated the chromatin structure at the binding motifs of two important genome regulators REST and CTCF in detail. Nucleosome positioning is maintained at REST binding motifs during neural cell development. In contrast, at CTCF sites nucleosome repositioning occurs during neural cell development. This work provides insight into the role of chromatin structure in the regulation of human neural cell differentiation.

Published
2015

9. College Students Talk Politics.

Author

Harwood Group, Bethesda, MD., Creighton, John A., and Harwood, Richard C.

Abstract

This volume reports on a study undertaken to determine views of college students themselves on civic life and politics and also follows four related studies and action research projects on the relationship between citizens and the political process. The central study was a series of 10 campus discussions in the focus group format, with college students in campuses across the nation. Those groups explored what college students believe it means to be a citizen, how students view politics today, how college students have learned what they know about politics and citizenship, how students would like politics practiced, and what opportunities students have for learning politics at the university. Key findings were that many students have concluded that politics is irrelevant holding a narrow view of politics; that students can imagine a different politics based on people coming together to find ways to talk and act on problems; and that students say they are not learning to practice politics as the political education they receive only reinforces everything they believe is wrong with politics. The volume closes by offering an agenda for changing how students view and participate in politics. An appendix describes the study methodology. (JB)

Published
1993

10. Cooling the perfect cup with Laplace.

Author

Harwood, R. C.

Subjects
*COFFEE cups, *DIFFERENTIAL equations, *STUDENT attitudes, *LAPLACE transformation, *MATHEMATICS education
Abstract

After waiting in a long line for your favourite cup of coffee, you finally sit down with your mug and find that the coffee is still scalding hot! How long do you need to wait before you can enjoy it? Once it cools enough, how much time do you have to enjoy it? Are there ways to speed up the process? These questions motivate the presented modelling scenario about tracking the temperature of a cup of coffee as it cools. Students are put in the role of an inquisitive coffee enthusiast who does their due diligence in preventing burns and carefully experimenting on their coffee so that they, and others to come, can enjoy that perfect cup. They identify their assumptions and interventions before developing model differential equations for each case, which force discontinuities on the derivative and even on the solution itself. Being familiar with basic Laplace transforms and learning key properties of the unit step and unit impulse functions, they solve these differential equations and compare the interval of time when the coffee will be at its peak level of enjoyment. This paper includes an implementation guide, grading rubric, example solutions, and example assessment questions. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

Author

Trubetskoy, Vassily, Pardinas, Antonio, Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B., Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A., Hall, Lynsey, Lam, Max, Watanabe, Kyoto, Frei, Oleksandr, Ge, Tian, Harwood, Janet C., Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L., Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G., Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z., Alptekin, Köksal, Als, Thomas D., Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A., Bass, Nicholas J., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Benyamin, Beben, Bergen, Sarah E., Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Affonseca Bressan, Rodrigo, Bromet, Evelyn J., Bruggeman, Richard, Buckley, Peter F., Buckner, Randy L., Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J., Calkins, Monica E., Carr, Vaughan J., Castle, David, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chaumette, Boris, Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cohen, David, Consoli, Angele, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L., De Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E., Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G., Fananas, Lourdes, Faraone, Stephen V., Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B., Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, Gershon, Elliot S., Giannitelli, Marianna, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., González Peñas, Javier, González-Pinto, Ana, Gopa, Srihari, Gratten, Jacob, Green, Michael F., Greenwood, Tiffany A., Guillin, Olivier, Gülöksüz, Sinan, Gur, Raquel E., Gur, Ruben C., Gutiérrez, Blanca, Hahn, Eric, Hakonarson, Hakon, Haroutunian, Vahram, Hartmann, Annette M., Harvey, Carol, Hayward, Caroline, Henskens, Frans A., Herms, Stefan, Hoffmann, Per, Howrigan, Daniel P., Ikeda, Masashi, Iyegbe, Conrad, Joa, Inge, Julià, Antonio, Kähler, Anna K., Kam-Thong, Tony, Kamatani, Yoichiro, Karachanak-Yankova, Sena, Kebir, Oussama, Keller, Matthew C., Kelly, Brian J., Khrunin, Andrey, Kim, Sung-Wan, Klovins, Janis, Kondratiev, Nikolay, Konte, Bettina, Kraft, Julia, Kubo, Michiaki, Kučinskas, Vaidutis, Ausrele Kučinskiene, Zita, Kusumawardhani, Agung, Kuzelov a-Ptackova, Hana, Land, Stefano, Lazzeroni, Laura C., Lee, Phil H., Legge, Sophie E., Lehrer, Douglas S., Lencer, Rebecca, Lerer, Bernard, Li, Miaoxin, Lieberman, Jeffrey, Light, Gregory A., Limborska, Svetlana, Liu, Chih-Min, Lönnqvist, Jouko, Loughland, Carmel M., Lubiski, Jan, Luykx, Jurjen J., Lynham, Amy, Macel Jr., Milan, Mackinnon, Andrew, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Malaspina, Dolores, Mallet, Jacques, Marder, Stephen R., Marsal, Sara, Martin, Alicia R., Martorell, Lourdes, Mattheisen, Manuel, McCarley, Robert W., McDonald, Colm, McGrath, John J., Medeiros, Helena, Meier, Sandra, Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihara, Mitjans, Marina, Molden, Espen, Molina, Esther, Molto, María Dolores, Mondelli, Valeria, Moreno, Carmen, Morley, Christopher P., Muntané, Gerard, Murphy, Kieran C., Myin-Germeys, Inez, Nenadić, Igor, Nestadt, Gerald, Nikitina-Zake, Liene, Noto, Cristiano, Neuchterlein, Keith H., O'Brien, Niamh Louise, O'Neill, F. Anthony., Oh, Sang-Yun, Olincy, Ann, Ota, Vanessa Kiyomi, Pantelis, Christos, Papadimitrou, George N., Paredella, Mara, Paurio, Tiina, Pellegrino, Renata, Periyasamy, Sathish, Perkins, Diana O., Pfuhlmann, Bruno, Pietilainen, Olli, Pimm, Jonathan, Porteous, David, Powell, John, Quattrone, Diego, Quested, Digby, Radant, Allen D., Rampino, Antonio, Rapaport, Mark H., Rautanen, Anna, Reichenberg, Abraham, Roe, Cheryl, Roffman, Joshua L., Roth, Julian, Rothermundt, Matthias, Rutten, Bart P. F., Saker-Delye, Safaa, Salomaa, Veiko, Sanjuan, Julio, Santoro, Marcos Leite, Savitz, Adam, Schall, Ulrich, Scott, Rodney J., Seidman, Larry J., Sharp, Sally Isabel, Shi, Jianxin, Sigurdsson, Engilbert, Sim, Kang, Skarabis, Nora, Slominsky, Petr, So, Hon-Cheong, Sobell, Janet L., Soderman, Erik, Stain, Helen J., Steen, Nils Eiel, Steixner-Kumar, Agnes, Stogmann, Elisabeth, Stone, William S., Straub, Richard E., Streit, Fabian, Stregman, Eric, Stroup, T. Scott, Subramaniam, Mythily, Sugar, Catherine A., Suvisaari, Jaana, Svrakic, Dragan M., Swerdlow, Neal R., Szatkiewicz, Jin P., Ta, Thi Minh Tam, and Takahashi, Atsushi

Abstract

Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.

Published
2022

14. Meaningful Chaos: How People Form Relationships with Public Concerns. A Report.

Author

Harwood Group, Bethesda, MD. and Harwood, Richard C.

Abstract

The formation of authentic public opinion requires confrontation with political realities and open discussion. This report presents findings of a study, conducted by The Harwood Group, that sought to describe the nature of the process through which citizens learn about public concerns and engage in them. The report argues that the seemingly chaotic process of forming opinions is actually one composed of meaningful patterns and principles. Data were derived from focus-group discussions with 6 groups representing a cross-section of American citizens, interviews with 13 experts, and a literature review. The study identified nine factors that play a pivotal role in citizens' involvement in public affairs: (1) a desire to make connections between public concerns; (2) personal context; (3) a desire for coherence; (4) a need for areas of ambivalence in the public arena; (5) emotion; (6) a desire for authenticity; (7) a desire to play a role in facilitating change; (8) individual catalysts in everyday life; and (9) mediating institutions that bring people together. (LMI)

Published
1993

15. Creating Empowering Campus Climates for Women.

Author

Neff, Laurie A. and Harwood, Patricia C.

Abstract

Describes University of Richmond and Westhampton College, which function in coordinate college model, defending this hybrid. Describes how two cooperating single-sex colleges share joint, common curriculum but maintain somewhat separate identities, as with different faculties, residence halls, student governments, and college traditions. Describes coordinate college model as cost effective and allowing for cross-sex social and intellectual contact. (NB)

Published
1991

23. The Impact of Complement Genes on the Risk of Late-Onset Alzheimer’s Disease

Author

Carpanini, Sarah M., Harwood, Janet C., Baker, Emily, Torvell, Megan, Consortium, The GERAD1 Consortium The GERAD1, Sims, Rebecca, Williams, Julie, and Morgan, B. Paul

Subjects
0301 basic medicine, lcsh:QH426-470, clusterin, Complement receptor 1, Genome-wide association study, Disease, Bioinformatics, Article, neuroinflammation, 03 medical and health sciences, Complement inhibitor, 0302 clinical medicine, Alzheimer Disease, Databases, Genetic, Genetic predisposition, Humans, Genetic Predisposition to Disease, complement, genetics, Age of Onset, Complement Activation, Genetics (clinical), Complement C1s, biology, Clusterin, late-onset Alzheimer’s disease, Complement (complexity), Complement system, lcsh:Genetics, complement receptor 1, 030104 developmental biology, Receptors, Complement 3b, biology.protein, biology.gene, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Late-onset Alzheimer’s disease (LOAD), the most common cause of dementia, and a huge global health challenge, is a neurodegenerative disease of uncertain aetiology. To deliver effective diagnostics and therapeutics, understanding the molecular basis of the disease is essential. Contemporary large genome-wide association studies (GWAS) have identified over seventy novel genetic susceptibility loci for LOAD. Most are implicated in microglial or inflammatory pathways, bringing inflammation to the fore as a candidate pathological pathway. Among the most significant GWAS hits are three complement genes: CLU, encoding the fluid-phase complement inhibitor clusterin, CR1 encoding complement receptor 1 (CR1), and recently, C1S encoding the complement enzyme C1s. Complement activation is a critical driver of inflammation, changes in complement genes may impact risk by altering the inflammatory status in the brain. To assess complement gene association with LOAD risk, we manually created a comprehensive complement gene list and tested these in gene-set analysis with LOAD summary statistics. We confirmed associations of CLU and CR1 genes with LOAD but showed no significant associations for the complement gene-set when excluding CLU and CR1. No significant association with other complement genes, including C1S, was seen in the IGAP dataset, however, these may emerge from larger datasets.

Published
2021
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24. In search of authenticity: Public Trust and the news media

Author

Harwood, Richard C.

Subjects
Press -- Public opinion, Journalism -- Public opinion, Government, Political science, Public opinion
Abstract

Throughout my work over the past twenty years, I have heard a clear call in America for leaders and institutions to act with greater authenticity. People want leaders and institutions [...]

Published
2004

25. Devotion: declaring our intentions in public life

Author

Harwood, Richard C.

Subjects
United States -- Political aspects -- Research, World Trade Center and Pentagon Attacks, 2001 -- Political aspects -- Research, Americans -- Political aspects -- Research, Mass media -- Research -- Political aspects, Telecommunications services industry -- Political aspects -- Research, Politics -- Research -- Political aspects, Communications industry -- Research -- Political aspects, Government, Political science, Telecommunications services industry, Research, Political aspects
Abstract

Abraham Lincoln once said, 'Why should there not be a patient confidence in the ultimate justice of the people? Is there any better or equal hope in the world?' Over [...]

Published
2003

26. We Can Heal Divides by Focusing Americans on Their Shared Goals

Author

Harwood, Richard C.

Subjects
Books, Organizations, Sociology and social work
Abstract

I RECENTLY ANNOUNCED a new book tour, and in just over two weeks' time, more than 90 communities and organizations asked me to come speak. I don't think it's because [...]

Published
2019

27. Standardized Performance Evaluation of Vehicles with Automated Capabilities

Author

Basantis, Alexis, Harwood, Leslie C., Doerzaph, Zachary R., and Neurauter, Luke

Subjects
automated, evaluation, Performance, capabilities, testing, standardized
Abstract

Advanced driver-assistance systems (ADAS) are becoming widely available in the new vehicle landscape, increasing of both vehicle occupants’ and other road users’ safety. In some vehicles, longitudinal and lateral positioning under certain conditions can be maintained, designating them as having either SAE level 1 (L1) or level 2 (L2) automated features. By developing a standardized set of tests to be applied to current L1 and L2 vehicles, while keeping the future advancement of automation in mind, these vehicles’ system performance, feature limitations, and performance consistency can be systematically evaluated. This project sought to develop an easily implementable, standardized set of testing procedures that could be quickly and inexpensively performed on automated vehicles to characterize their feature capabilities and limitations. Such information is useful to private or public organizations interested in a standardized approach to classifying vehicle capabilities, whether for informing the expectation of operators, or for cataloging and learning from the variety of implementation alternatives. Although not the primary purpose, this project may also help inform efforts to develop certification or other standardized vehicle performance efforts. The results of this project showed that specific roadway factors affected automated feature performance and that there was significant performance variability across test vehicles.

Published
2019

28. The public realm: where Americans can address their concerns

Author

Harwood, Robert C.

Subjects
Public institutions -- Public relations -- Analysis, Social problems -- Analysis, Government, Political science, Sociology and social work, Company public relations, Public relations, Analysis
Abstract

As the 20th century draws to a close, the US seems stuck in a political deadlock: the public remains deeply concerned about the state of the nation's political and civic [...]

Published
1995

29. We must engage the public on the health care issue

Author

Harwood, Richard C.

Subjects
Health care reform -- Management, Government, Political science, Company business management, Management
Abstract

Health care reform is upon us and there is a real possibility for change. Yet the opportunity easily could be squandered by making a hard sell to the public too [...]

Published
1994

30. Devotion

Author

Harwood, Richard C.

Subjects
Devotion, General interest, News, opinion and commentary
Abstract

A patriotism rooted in devotion informs that people hold the ability to make things happen, and that they do not have to wait for others to give them permission to act. Everyone contributes to what is called to exercise a new devotion to politics and public life, for it is only when they stand in the public square, the issue arises whether they can actually make a difference together.

Published
2003

31. Finding the right path: public agencies and civic engagement

Author

Harwood, Richard C.

Subjects
Government, Political science
Abstract

Public agencies across the nation are under increasing pressure to engage the public. Some agencies feel the pressure because they have failed to meet the public's expectations, or they are [...]

Published
2004

33. Stepping Forward.

Author

Harwood, Richard C.

Subjects
UNITED States social conditions, COMMUNITY life, SOCIAL change, CIVIL society, TWENTY-first century
Abstract

Many Americans feel a sense of despair today. They've lost their faith in leaders and institutions, politics, and public discourse. In Stepping Forward, Richard C. Harwood suggests that there's a path forward out of the current levels of frustration, cynicism, and gridlock. He offers concrete recommendations for people to co-create their communities and generate civic faith. As a result, communities and their residents will regain a sense of dignity and hope.

Published
2020

34. Closing the Gap: Meeting the Small Business Training Challenge in Connecticut.

Author

Jobs for the Future, Inc., West Somerville, MA. and Harwood, Richard C.

Abstract

The training needs of Connecticut's small businesses and their employees are not being adequately met. Small businesses face an economy placing increasing demands on them: a worsening labor shortage, an aging work force, and changing skills in the workplace. Gaps in private and public sector training programs impede small businesses from meeting the training challenges these demands present. This report identifies the following key training issues: on-the-job training lacks structure, public sector programs are fragmented and reach few people, training programs are too costly, and small companies do not have the resources to develop in-house training programs nor to purchase outside training programs. The report makes recommendations to address these issues. It calls for action in four areas of small business training: (1) to improve the content of public and private sector training programs for on-the-job, basic skills, customized, and formal training; (2) to strengthen the delivery of these programs; (3) to enhance the communications on training goals and programs between suppliers and consumers of training and between employers and employees; and (4) to increase the coordination of training activities in the state to fill gaps and avoid unnecessary duplication. The report's methodology (literature review, public attitude surveys, and in-depth follow-up interviews) is described. Twenty references and a list of experts interviewed are appended. (KC)

Published
1989

36. Oscillation-free method for semilinear diffusion equations under noisy initial conditions

Author

Harwood, R. C., Zhang, Likun, and Manoranjan, V. S.

Subjects
65M06, 65M12, 65Z05, 35K57, 35K58, 35B05, FOS: Mathematics, Numerical Analysis (math.NA), Mathematics - Numerical Analysis
Abstract

Noise in initial conditions from measurement errors can create unwanted oscillations which propagate in numerical solutions. We present a technique of prohibiting such oscillation errors when solving initial-boundary-value problems of semilinear diffusion equations. Symmetric Strang splitting is applied to the equation for solving the linear diffusion and nonlinear remainder separately. An oscillation-free scheme is developed for overcoming any oscillatory behavior when numerically solving the linear diffusion portion. To demonstrate the ills of stable oscillations, we compare our method using a weighted implicit Euler scheme to the Crank-Nicolson method. The oscillation-free feature and stability of our method are analyzed through a local linearization. The accuracy of our oscillation-free method is proved and its usefulness is further verified through solving a Fisher-type equation where oscillation-free solutions are successfully produced in spite of random errors in the initial conditions., 19 pages, 9 figures

Published
2016

39. I. Science and Humanism

Author

Szent-Györgi, Albert, Monod, Jacques, Bronowski, Jacob, Leitenberg, Milton, Lal, Shivaji, Dickson, David, Oglesby, Carl, Steintrager, James, Glass, H. B., Michaelis, Michael, Harwood, E. C., and Handy, Rollo

Published
1971

40. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease.

Author

Baker, Emily, Sims, Rebecca, Leonenko, Ganna, Frizzati, Aura, Harwood, Janet C., Grozeva, Detelina, null, null, Morgan, Kevin, Passmore, Peter, Holmes, Clive, Powell, John, Brayne, Carol, Gill, Michael, Mead, Simon, Bossù, Paola, Spalletta, Gianfranco, Goate, Alison M., Cruchaga, Carlos, Maier, Wolfgang, and Heun, Reinhard

Subjects
ALZHEIMER'S disease, SINGLE nucleotide polymorphisms, GENES, CIRCADIAN rhythms, MOLECULAR genetics, CHOLESTEROL metabolism
Abstract

Late onset Alzheimer’s disease is the most common form of dementia for which about 30 susceptibility loci have been reported. The aim of the current study is to identify novel genes associated with Alzheimer’s disease using the largest up-to-date reference single nucleotide polymorphism (SNP) panel, the most accurate imputation software and a novel gene-based analysis approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer’s Project Consortium, comprising over 7 million genotypes from 17,008 Alzheimer’s cases and 37,154 controls. In addition to earlier reported genes, we detected three novel gene-wide significant loci PPARGC1A (p = 2.2 × 10−6), RORA (p = 7.4 × 10−7) and ZNF423 (p = 2.1 × 10−6). PPARGC1A and RORA are involved in circadian rhythm; circadian disturbances are one of the earliest symptoms of Alzheimer’s disease. PPARGC1A is additionally linked to energy metabolism and the generation of amyloid beta plaques. RORA is involved in a variety of functions apart from circadian rhythm, such as cholesterol metabolism and inflammation. The ZNF423 gene resides in an Alzheimer’s disease-specific protein network and is likely involved with centrosomes and DNA damage repair. [ABSTRACT FROM AUTHOR]

Published
2019
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41. Thought My Soul Would Rise and Fly.

Author

Harwood, Richard C.

Subjects
*SOCIAL change, SOCIAL conditions in the United States, 1980-
Abstract

Presents a speech by Richard C. Harwood, founder and president of The Harwood Institute for Public Innovation, delivered on April 4, 2001 to the United Way of Flint and Genesee County in Flint, Michigan. His findings that the United States is a nation of mistrust; Notion that societal change is possible with collective effort; How we can all come to believe in hope and move forward.

Published
2001

42. LiDAR: Another Potential Data Source

Author

Harwood, Leslie C., Doerzaph, Zachary R., and Virginia Tech Transportation Institute

Subjects
Urban intersection visibility, Light detection and ranging
Abstract

LiDAR (Light Detection and Ranging) is a valuable tool for evaluating line of sight. Though setup is time-intensive, it can to be used as an automated process. It is more objective and efficient than video reduction or survey methods. Presented at the Fourth International Symposium on Naturalistic Driving Research in Blacksburg, VA

Published
2014

43. Originating Civic Faith.

Author

Harwood, Richard C.

Subjects
*CIVIC improvement, *CIVICS
Abstract

Presents a speech by Richard C. Harwood, President of the Harwood Institute for Public Innovation, delivered to the Health Resources and Services Administration and Bureau of Primary Health Care at a symposium in Bethesda, Maryland, on June 30, 1999, dealing with the issue of civic faith in the United States.

Published
1999

44. ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer.

Author

Harwood, Franklin C., Geltink, Ramon I. Klein, O'Hara, Brendan P., Cardone, Monica, Janke, Laura, Finkelstein, David, Entin, Igor, Paul, Leena, Houghton, Peter J., and Grosveld, Gerard C.

Subjects
*RAPAMYCIN, *RHABDOMYOSARCOMA, *GENE expression, *TRANSCRIPTION factors, *CYTOPLASM, *CELL lines
Abstract

The article looks at a study which show that tumorigenicity of mechanistic target of rapamycin (mTORC3) in a rhabdomyosarcoma mouse model in which transgenic ETV7 expression accelerates tumor onset and promotes tumor penetrance. Topics discussed include E26 transformation–specific transcription factor ETV7 interacts with mTOR in the cytoplasm, human cancers activate mTORC3 at considerable frequency and tumor cell lines that lose mTORC3 expression become rapamycin-sensitive.

Published
2018
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45. Understanding the Community's Civic Life

Author

Harwood, Richard C.

Subjects
Journalists -- Management -- Methods, Journalism -- Methods -- Management, Community life -- Media coverage -- Methods, Business, Literature/writing, Mass communications, Publishing industry, Company business management, Management, Methods, Media coverage
Abstract

Journalists' tools include new questions and different sources. Tapping civic life is another name for practicing good journalism. It should be the very essence of how journalists see and relate [...]

Published
2001

50. Red states vs. blue states; A dangerous shorthand

Author

Harwood, Richard C.

Subjects
General interest, News, opinion and commentary
Abstract

WHEN I WORK with community leaders, organizations, and citizens across the nation, I must confess that I never meet people with red or blue faces. Nor have I found people [...]

Published
2004

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