317 results on '"Hartman, George D."'
Search Results
2. Discovery of selective glucocorticoid receptor modulator MK-5932
3. Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Versus Reproductive Physiology
4. Stereospecific reduction of a potent kinesin spindle protein (KSP) inhibitor in human tissues
5. Oxadiazepinone HBV capsid assembly modulators
6. Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands
7. Identification of a new class of HBV capsid assembly modulator
8. Protein Farnesyltransferase Inhibitors Block the Growth of ras-Dependent Tumors in Nude Mice
9. SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators
10. Farnesyltransferase inhibitors and anti-Ras therapy
11. Pharmacokinetics and Pharmacodynamics of L-703,014, a Potent Fibrinogen Receptor Antagonist, After Intravenous and Oral Administration in the Dog
12. Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences
13. Anti-Resorptive and Anabolic Bone Agents
14. Anions Modulate the Potency of Geranylgeranyl-Protein Transferase I Inhibitors
15. Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics
16. P450s under Restriction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals.
17. Fibrinogen Receptor Antagonist-Induced Thrombocytopenia in Chimpanzee and Rhesus Monkey Associated With Preexisting Drug-Dependent Antibodies to Platelet Glycoprotein IIb/IIIa
18. Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase
19. Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors
20. Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
21. Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
22. Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase
23. Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M1 positive allosteric modulators
24. Benzimidazole CB2 agonists: Design, synthesis and SAR
25. Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)
26. Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity
27. Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates
28. Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3)
29. High concentration electrophysiology-based fragment screen: Discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors
30. Fused heterocyclic M 1 positive allosteric modulators
31. Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy
32. Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia
33. Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series
34. Pyridyl amides as potent inhibitors of T-type calcium channels
35. Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
36. Tricyclic imidazole antagonists of the Neuropeptide S Receptor
37. Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
38. Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists
39. 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
40. Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel
41. Heterocyclic fused pyridone carboxylic acid M 1 positive allosteric modulators
42. Hydroxy cycloalkyl fused pyridone carboxylic acid M 1 positive allosteric modulators
43. Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists
44. N-Heterocyclic derived M 1 positive allosteric modulators
45. Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M 1 positive allosteric modulators
46. Pyridine containing M 1 positive allosteric modulators with reduced plasma protein binding
47. Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)
48. Discovery of GlyT1 inhibitors with improved pharmacokinetic properties
49. Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors
50. Development of thioquinazolinones, allosteric Chk1 kinase inhibitors
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