Search

Abstract Background Aging is one of the dominant factors contributing to erectile dysfunction (ED), and effective treatments for age-associated ED are urgently demanded. In this study, the therapeutic efficiency of bone marrow-derived mesenchymal stem cells (BMSCs) overexpressing microRNA-145 (miR-145) was evaluated in ED. Methods Sixty male Sprague-Dawley rats (24 months old) were randomly divided into 4 treatment groups (n = 15/group): PBS (control), BMSCs, BMSCs transfected with a blank vector (vector-BMSCs), and BMSCs transfected with a lentivirus overexpressing miR-145 (OE-miR-145-BMSCs). Fourteen days after transplantation of BMSCs, erectile function was evaluated by measuring intra-cavernous pressure (ICP) and mean arterial pressure (MAP). Subsequently, penile erectile tissues were harvested and subjected to Masson staining, qRT-PCR, immunofluorescence staining, dual luciferase assay, and Western blot analysis. Results Fourteen days after transplantation, the ICP/MAP was 0.79 ± 0.05 in the OE-miR-145-BMSC group, 0.61 ± 0.06 in the BMSC group, 0.57 ± 0.06 in the vector-BMSC group, and 0.3 ± 0.01 in the PBS group. Treatment with OE-miR-145-BMSCs significantly improved ED (P

Inorganic boron-based nanostructures have great potential for field emission (FE), flexible displays, superconductors, and energy storage because of their high melting point, low density, extreme hardness, and good chemical stability. Until now, most researchers have been focused on one-dimensional (1D) boron-based nanostructures (rare-earth boride (REB6) nanowires, boron nanowires, and nanotubes). Currently, two-dimensional (2D) borophene attracts most of the attention, due to its unique physical and chemical properties, which make it quite different from its corresponding bulk counterpart. Here, we offer a comprehensive review on the synthesis methods and optoelectronics properties of inorganic boron-based nanostructures, which are mainly concentrated on 1D rare-earth boride nanowires, boron monoelement nanowires, and nanotubes, as well as 2D borophene and borophane. This review paper is organized as follows. In Section I, the synthesis methods of inorganic boron-based nanostructures are systematically introduced. In Section II, we classify their optical and electrical transport properties (field emission, optical absorption, and photoconductive properties). In the last section, we evaluate the optoelectronic behaviors of the known inorganic boron-based nanostructures and propose their future applications.

Based on the morphology characteristics, low-dimensional (LD) nanostructures with high aspect ratio can be usually divided into nanowire, nanocone, nanotube, nanorod, nanoribbon, nanobelt and so on. Among numerous LD nanostructures, boron-based nanostructures attracted much interest in recent years because they have high melting-point, large electric and thermal conductivity, and low work function. Compared to traditional thermal emission, field emission (FE) has notable advantages, such as lower power dissipation, longer working life, room-temperature operation, higher brightness and faster switching speed. Most studies reveal they have lower turn-on and threshold fields as well as high current density, which are believed as ideal cold cathode nanomaterials. In this review, we will firstly introduce the growth methods of LD boron-based nanostructures (boron monoelement and rare-earth metal hexaboride). Then, we will discuss their FE properties and applications. At last, the conclusions and outlook will be summarized based on the above studies.

The document is a contents list for the Journal of Materials Chemistry C, which covers a wide range of topics including heavy metal-free quantum dots, electrochromic materials, solar energy, and inorganic photoresists. The journal aims to connect the world with the chemical sciences and is published by The Royal Society of Chemistry. One article discussed in the document focuses on the development of an organic photoelectrochemical transistor for the detection of uric acid. The transistor, based on a Fe-MOF@PANI/carbon fiber structure, shows promising results in terms of sensitivity and selectivity. The authors provide detailed information on the fabrication process and characterization of the transistor. This research has potential applications in the field of biomedical sensing and could contribute to the development of more efficient and accurate uric acid detection methods. [Extracted from the article]

All-inorganic perovskites have a high absorption coefficient, long carrier diffusion length, large carrier mobility, tunable direct bandgap and good ambient stability and are therefore considered as an ideal candidate for the new generation of optoelectronic devices. Many methods have been used to improve their photoresponsive performances, among which localized surface plasmon resonance (LSPR) is a very effective means. Theoretically, the enhancement effect of LSPR is strongly dependent on the relationship between the LSPR wavelength and material, but related research has not been reported until now due to the challenge of fabricating perovskite materials with an atom-level smooth surface. Herein, we successfully developed a simple polydimethylsiloxane (PDMS)-assisted slow evaporation route to fabricate plenty of supersmooth CsPbBr3 microplates with a mean surface roughness of only 0.6 nm. Subsequently, gold nanospheres (Au NSs) were deposited on the surface of the perovskite microplates to examine the effect of the diameter of the gold nanospheres on the LSPR wavelength. Based on photoluminescence (PL), dark-field scattering spectroscopy and finite-difference-time-domain (FDTD) simulation results, the optimal Au NS diameter was found to be nearly equal to an LSPR wavelength of 60 nm, where the Au NSs and CsPbBr3 microplates had the strongest coupling effect. In contrast with a pristine CsPbBr3 microplate, the on/off ratio of the CsPbBr3 microplate covered with Au NSs was observed to increase from 109 to 448 and responsivity could reach as high as 8430 mA W−1, which is comparable to many other excellent perovskite-based photodetectors. An ultrahigh plasmonic enhancement factor of about 1145% was suggested to be responsible for the excellent photoresponsive performance of the hybrid Au NS-CsPbBr3 photodetector. Our research may shed new light on accelerating the development of visible-light detectors based on perovskite materials. [ABSTRACT FROM AUTHOR]

Background: Aging is one of the dominant factors contributing to erectile dysfunction (ED), and effective treatments for age-associated ED are urgently demanded. In this study, the therapeutic efficiency of bone marrow-derived mesenchymal stem cells (BMSCs) overexpressing microRNA-145 (miR-145) was evaluated in ED. Methods: Sixty male Sprague-Dawley rats (24 months old) were randomly divided into 4 treatment groups (n = 15/group): PBS (control), BMSCs, BMSCs transfected with a blank vector (vector-BMSCs), and BMSCs transfected with a lentivirus overexpressing miR-145 (OE-miR-145-BMSCs). Fourteen days after transplantation of BMSCs, erectile function was evaluated by measuring intra-cavernous pressure (ICP) and mean arterial pressure (MAP). Subsequently, penile erectile tissues were harvested and subjected to Masson staining, qRT-PCR, immunofluorescence staining, dual luciferase assay, and Western blot analysis. Results: Fourteen days after transplantation, the ICP/MAP was 0.79 ± 0.05 in the OE-miR-145-BMSC group, 0.61 ± 0.06 in the BMSC group, 0.57 ± 0.06 in the vector-BMSC group, and 0.3 ± 0.01 in the PBS group. Treatment with OE-miR-145-BMSCs significantly improved ED (P < 0.05), and the treatment increased the smooth muscle content in the penis tissues of ED rats (P < 0.05). In the OE-miR-145-BMSC group, the expression levels of α-SMA, desmin, and SM-MHC were higher than they were in the other ED groups (P < 0.05). In addition, the levels of collagen 1, MMP2, and p-Smad2 in the BMSC-treated group, especially in the OE-miR-145-BMSC group, were lower than those in the control group (P < 0.05). Conclusions: MicroRNA-145 engineered BMSCs effectively attenuate age-related ED. Transplantation of miR-145-overexpressing BMSCs may provide a promising novel avenue for age-associated ED therapy. [ABSTRACT FROM AUTHOR]

Based on the morphology characteristics, low-dimensional (LD) nanostructures with high aspect ratio can be usually divided into nanowire, nanocone, nanotube, nanorod, nanoribbon, nanobelt and so on. Among numerous LD nanostructures, boron-based nanostructures attracted much interest in recent years because they have high melting-point, large electric and thermal conductivity, and low work function. Compared to traditional thermal emission, field emission (FE) has notable advantages, such as lower power dissipation, longer working life, room-temperature operation, higher brightness and faster switching speed. Most studies reveal they have lower turn-on and threshold fields as well as high current density, which are believed as ideal cold cathode nanomaterials. In this review, we will firstly introduce the growth methods of LD boron-based nanostructures (boron monoelement and rare-earth metal hexaboride). Then, we will discuss their FE properties and applications. At last, the conclusions and outlook will be summarized based on the above studies. [ABSTRACT FROM AUTHOR]

Inorganic boron-based nanostructures have great potential for field emission (FE), flexible displays, superconductors, and energy storage because of their high melting point, low density, extreme hardness, and good chemical stability. Until now, most researchers have been focused on one-dimensional (1D) boron-based nanostructures (rare-earth boride (REB6) nanowires, boron nanowires, and nanotubes). Currently, two-dimensional (2D) borophene attracts most of the attention, due to its unique physical and chemical properties, which make it quite different from its corresponding bulk counterpart. Here, we offer a comprehensive review on the synthesis methods and optoelectronics properties of inorganic boron-based nanostructures, which are mainly concentrated on 1D rare-earth boride nanowires, boron monoelement nanowires, and nanotubes, as well as 2D borophene and borophane. This review paper is organized as follows. In Section I, the synthesis methods of inorganic boron-based nanostructures are systematically introduced. In Section II, we classify their optical and electrical transport properties (field emission, optical absorption, and photoconductive properties). In the last section, we evaluate the optoelectronic behaviors of the known inorganic boron-based nanostructures and propose their future applications. [ABSTRACT FROM AUTHOR]