1. Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype
- Author
-
Amnon Peled, Odit Gutwein, Hanna Wald, Katia Beider, Olga Ostrovsky, Arnon Nagler, Eithan Galun, Maya Koren-Michowitz, Hanna Bitner, Michal Abraham, and Merav Leiba
- Subjects
Adult ,Male ,Chemokine ,Receptors, CXCR4 ,Stromal cell ,Macrophage polarization ,Apoptosis ,Cell Line, Tumor ,medicine ,M2 macrophages ,Humans ,Scavenger receptor ,Aged ,Cell Proliferation ,CXCR4 ,biology ,Monocyte ,Macrophages ,Cell Polarity ,Middle Aged ,MM ,Molecular biology ,Chemokine CXCL12 ,medicine.anatomical_structure ,Phenotype ,Oncology ,Immunology ,biology.protein ,Tumor necrosis factor alpha ,Female ,Bone marrow ,Multiple Myeloma ,CD163 ,Research Paper ,Signal Transduction - Abstract
// Katia Beider 1 , Hanna Bitner 1 , Merav Leiba 1 , Odit Gutwein 1 , Maya Koren-Michowitz 1 , Olga Ostrovsky 1 , Michal Abraham 3 , Hanna Wald 3 , Eithan Galun 2 , Amnon Peled 2 and Arnon Nagler 1 1 Hematology Division and CBB, Guy Weinshtock Multiple Myeloma Foundation, Chaim Sheba Medical Center, Tel-Hashomer, Israel 2 Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel 3 Biokine Therapeutics Ltd., Science Park, Ness Ziona, Israel Correspondence: Arnon Nagler, email: // Keywords : MM, M2 macrophages, CXCR4 Received : May 21, 2014 Accepted : July 11, 2014 Published : July 12, 2014 Abstract Multiple myeloma (MM) cells specifically attract peripheral-blood monocytes, while interaction of MM with bone marrow stromal cells ( BMSCs) significantly increased monocyte recruitment (p
- Published
- 2014