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2 results on '"Hanen Ghozzi"'

1. Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients

Author

Mariam Ammar, Soumaya Yaich, Ahmed Hakim, Hanen Ghozzi, Zouheir Sahnoun, Mohamed Ben Hmida, Khaled Zghal, and Lobna Ben Mahmoud

Subjects
Tacrolimus, post-transplantation, oxidative stress, trough level, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Background The effect of tacrolimus (TAC) on oxidative stress after kidney transplantation (KT) is unclear. This study aimed to evaluate the influence of TAC trough levels of oxidative stress status in Tunisian KT patients during the post-transplantation period (PTP).Methods A prospective study including 90 KT patients was performed. TAC whole-blood concentrations were measured by the microparticle enzyme immunoassay method and adjusted according to the target range. Plasma levels of oxidants (malondialdehyde (MDA) and advanced oxidation protein products (AOPP)) and antioxidants (ascorbic acid, glutathione (GSH), glutathione peroxidase (GPx), and superoxide dismutase (SOD)) were measured using spectrophotometry. The subjects were subdivided according to PTP into three groups: patients with early, intermediate, and late PT. According to the TAC level, they were subdivided into LL-TAC, NL-TAC, and HL-TAC groups.Results A decrease in MDA levels, SOD activity, and an increase in GSH levels and GPx activity were observed in patients with late PT compared to those with early and intermediate PT (p

Published
2024
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2. Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study

Author

Hanen Ghozzi, Lobna Ben Mahmoud, Moez Elloumi, Ahmed Hakim, Mariam Ammar, Malek Mseddi, Khaled Mounir Zeghal, Moez Medhaffar, and Zouheir Sahnoun

Subjects
0301 basic medicine, Male, Clinical Biochemistry, Ascorbic Acid, medicine.disease_cause, Gastroenterology, Antioxidants, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Malondialdehyde, Immunology and Allergy, Research Articles, chemistry.chemical_classification, biology, Glutathione peroxidase, Myeloid leukemia, Hematology, Middle Aged, Glutathione, Enzymes, Medical Laboratory Technology, Treatment Outcome, Advanced Oxidation Protein Products, Catalase, 030220 oncology & carcinogenesis, Imatinib Mesylate, Female, Research Article, Microbiology (medical), Adult, medicine.medical_specialty, Tunisia, Antineoplastic Agents, Superoxide dismutase, 03 medical and health sciences, chronic myeloid leukemia, Internal medicine, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, medicine, Humans, Vitamin C, business.industry, Biochemistry (medical), Public Health, Environmental and Occupational Health, Oxidative Stress, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, Case-Control Studies, biology.protein, imatinib resistance, business, Oxidative stress
Abstract

Background This work aimed to evaluate oxidative stress in chronic myeloid leukemia (CML) patients treated with tunisian (IM) vs controls and in CML patients with resistance to IM vs patients without resistance to IM. Methods The study included 40 CML patients and 34 controls. Of 40 patients with CML, 26 patients were developed in resistance to IM. The oxidant/antioxidant markers were evaluated by spectrophotometric methods for all used samples. Results For CML patients, increased malondialdehyde (MDA) and advanced oxidation protein products (AOPP) levels were found compared to controls (P, High malondialdehyde and advanced oxidation of protein products levels were evidenced in chronic myeloid leukemia. Disturbed enzymatic and no enzymatic defenses were found in plasma of chronic myeloid leukemia patients. Patients with resistance to imatinib revealed more pronounced oxidant/antioxidant markers than no‐resistant chronic myeloid leukemia patients. Hydrogen peroxide was incriminated in the disturbed oxidative profile in chronic myeloid leukemia patients with resistance to imatinib.

Published
2019

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