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1. An algorithm for calculating exam quality as a basis for performance-based allocation of funds at medical schools

Author

Kirschstein, Timo, Wolters, Alexander, Lenz, Jan-Hendrik, Fröhlich, Susanne, Hakenberg, Oliver, Kundt, Günther, Darmüntzel, Martin, Hecker, Michael, Altiner, Attila, and Müller-Hilke, Brigitte

Subjects
exam quality, item difficulty, discrimination, reliability, performance based allocation of funds in teaching, Special aspects of education, LC8-6691, Medicine
Abstract

Objective: The amendment of the Medical Licensing Act (ÄAppO) in Germany in 2002 led to the introduction of graded assessments in the clinical part of medical studies. This, in turn, lent new weight to the importance of written tests, even though the minimum requirements for exam quality are sometimes difficult to reach. Introducing exam quality as a criterion for the award of performance-based allocation of funds is expected to steer the attention of faculty members towards more quality and perpetuate higher standards. However, at present there is a lack of suitable algorithms for calculating exam quality.Methods: In the spring of 2014, the students‘ dean commissioned the „core group“ for curricular improvement at the University Medical Center in Rostock to revise the criteria for the allocation of performance-based funds for teaching. In a first approach, we developed an algorithm that was based on the results of the most common type of exam in medical education, multiple choice tests. It included item difficulty and discrimination, reliability as well as the distribution of grades achieved. Results: This algorithm quantitatively describes exam quality of multiple choice exams. However, it can also be applied to exams involving short assay questions and the OSCE. It thus allows for the quantitation of exam quality in the various subjects and – in analogy to impact factors and third party grants – a ranking among faculty. Conclusion: Our algorithm can be applied to all test formats in which item difficulty, the discriminatory power of the individual items, reliability of the exam and the distribution of grades are measured. Even though the content validity of an exam is not considered here, we believe that our algorithm is suitable as a general basis for performance-based allocation of funds.

Published
2016
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3. Simulation of the effects of molecular urine markers in follow-up of patients with high-risk non-muscle invasive bladder cancer

Author

Benderska-Söder, Natalya, Ecke, Thorsten, Kleinlein, Lisa, Roghmann, Florian, Bismarck, Ekkehardt, van Rhijn, Bas W.G., Stenzl, Arnulf, Witjes, Johannes Alfred, Todenhöfer, Tilman, Hakenberg, Oliver W., Grimm, Marc Oliver, Goebell, Peter J., Burger, Maximilian, Jensen, Jorgen Bjerggaard, and Schmitz-Dräger, Bernd J.

Published
2024
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4. Corporal Skip Metastases in Penile Squamous Cell Carcinoma: An Unknown and Distinct Pattern of Spread with Poor Prognosis

Author

Elst, Laura, Vreeburg, Manon T.A., de Vries, Hielke Martijn, Vandermaesen, Kaat, Murphy, Titus, Churchill, James, Fallara, Giuseppe, Sanchez, Darren, Falcone, Marco, Garcia-Perdomo, Herney Andres, Pettaway, Curtis, Hakenberg, Oliver, Johnstone, Peter, Spiess, Philippe E., Muneer, Asif, Sangar, Vijay, Parnham, Arie, Ayres, Benjamin, Watkin, Nick, Brouwer, Oscar R., and Albersen, Maarten

Published
2024
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5. Rescue Allocation Modes in Eurotransplant Kidney Transplantation: Recipient Oriented Extended Allocation Versus Competitive Rescue Allocation—A Retrospective Multicenter Outcome Analysis

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, Hüser, Norbert, Hartmann, Daniel, Heemann, Uwe, Tieken, Ineke, Zanen, Wouter, Vogelaar, Serge, Rosenkranz, Alexander R., Schneeberger, Stefan, Függer, Reinhold, Berlakovich, Gabriela, Ysebaert, Dirk R., Jacobs-Tulleneers-Thevissen, Daniel, Mikhalski, Dimitri, van Laecke, Steven, Kuypers, Dirk, Mühlfeld, Anja S., Viebahn, Richard, Pratschke, Johann, Melchior, Sebastian, Hauser, Ingeborg A., Jänigen, Bernd, Weimer, Rolf, Richter, Nicolas, Foller, Susan, Schulte, Kevin, Kurschat, Christine, Harth, Ana, Moench, Christian, Rademacher, Sebastian, Nitschke, Martin, Krämer, Bernhard K., Renders, Lutz, Koliogiannis, Dionysios, Pascher, Andreas, Hoyer, Joachim, Weinmann-Menke, Julia, Schiffer, Mario, Banas, Bernhard, Hakenberg, Oliver, Schwenger, Vedat, Nadalin, Silvio, Lopau, Kai, Piros, Laszlo, Nemes, Balazs, Szakaly, Peter, Bouts, Antonia, Bemelman, Frederike J., Sanders, Jan S., de Vries, Aiko P. J., Christiaans, Maarten H. L., Hilbrands, Luuk, van Zuilen, Arjan D., Arnol, Miha, Stippel, Dirk, and Wahba, Roger

Published
2024
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6. Predicting Limited Survival Following Inguinal Lymph Node Dissection in Penile Cancer: Should We Revisit the Goals of Care?

Author

Hugar, Lee A., Peak, Taylor C., Naqvi, Mahrukh, Kim, Youngchul, Bandini, Marco, Pederzoli, Filippo, Marandino, Laura, Albersen, Maarten, Roussel, Eduard, Zhu, Yao, Ye, Ding-Wei, Ornellas, Antonio A., Catanzaro, Mario, Hakenberg, Oliver W., Heidenreich, Axel, Haidl, Friederike, Watkin, Nick, Ager, Michael, Briganti, Alberto, Salvioni, Roberto, Chakiryan, Nicholas H., Montorsi, Francesco, Necchi, Andrea, and Spiess, Philippe E.

Published
2023
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7. A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program

Author

Tieken, I., Haasnoot, G., van Meel, M., Rump, L.C., Rosenkranz, A., Horn, S., Margreiter, R., Schneeberger, S., Oberbauer, R., Pohanka, E., Függer, F., Mühlbacher, F., Berlakovich, G., Meurisse, M., Weekers, L., Ysebaert, D., Wissing, K.M., Mikhalski, D., Mourad, M., van Biesen, W., Kuypers, D., Floege, J., Anthuber, M., Viebahn, R., Schenker, P., Budde, K., Pratschke, J., Zidek, W., Melchior, S., Woitas, R., Strassburg, C.H., Hugo, C., Wirth, M., Schiffer, M., Kribben, A., Pisarski, P., Fichtner-Feigl, S., Haubitz, M., Weimer, R., Weithofer, P., Fornara, P., Fisher, L., Sester, U., Zeier, M., Kliem, V., Klempnauer, l, Grimm, M.O., Kunzendorf, U., Stippel, D., Arns, W., Mönch, C., Nitschke, M., Bartels, M., Krämer, B., Kruger, B., Heemann, U., Werner, J., Hoyer, J., Wolters, H.H., Suwelack, B., Lutz, J., Banas, B., Hakenberg, O., Olbricht, C.J., Kalus, M., Schwenger, V., Nadalin, S., Schröppel, B., Lopau, K., Seelen, M.A.J., Berger, S.P., de Fijter, J.W., van der Linden, S.J., Christiaans, M.H.L., van de Wetering, J., van Zuilen, A.D., Bemelman, F., Nurmohamed, A., Hilbrands, L., de Fijter, Johan, Dreyer, Geertje, Mallat, Marko, Budde, Klemens, Pratschke, Johann, Klempnauer, Jürgen, Zeier, Martin, Arns, Wolfgang, Hugo, Christian, Rump, Lars-Christian, Hauser, Ingeborg, Schenker, Peter, Schiffer, Mario, Grimm, Marc-Oliver, Kliem, Volker, Olbricht, Christoph J., Pisarski, Przemyslaw, Banas, Bernhard, Suwelack, Barbara, Hakenberg, Oliver, Berlakovich, Gabriela, Schneeberger, Stefan, van de Wetering, Jacqueline, Berger, Stefan, Bemelman, Frederike, Kuypers, Dirk, Heidt, Sebastiaan, Rahmel, Axel, Claas, Frans, Peeters, Patrick, Oberbauer, Rainer, Heemann, Uwe, and Krämer, Bernhard K.

Published
2023
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8. Therapy of clinical stage IIA and IIB seminoma: a systematic review

Author

Heinzelbecker, Julia, Schmidt, Stefanie, Lackner, Julia, Busch, Jonas, Bokemeyer, Carsten, Classen, Johannes, Dieing, Annette, Hakenberg, Oliver, Krege, Susanne, Papachristofilou, Alexandros, Pfister, David, Ruf, Christian, Schmelz, Hans, Schmidberger, Heinz, Souchon, Rainer, Winter, Christian, Zengerling, Friedemann, Kliesch, Sabine, Albers, Peter, and Oing, Christoph

Published
2022
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11. Association Between Human Papillomavirus Infection and Outcome of Perioperative Nodal Radiotherapy for Penile Carcinoma

Author

Bandini, Marco, Ross, Jeffrey S., Zhu, Yao, Ye, Ding-Wei, Ornellas, Antonio A., Watkin, Nick, Ayres, Benjamin A., Hakenberg, Oliver W., Heidenreich, Axel, Salvioni, Roberto, Catanzaro, Mario, Raggi, Daniele, Giannatempo, Patrizia, Marandino, Laura, Haidl, Friederike, Pederzoli, Filippo, Briganti, Alberto, Montorsi, Francesco, Chipollini, Juan, Azizi, Mounsif, De Meerleer, Gert, Brouwer, Oscar R., Grass, G. Daniel, Johnstone, Peter A., Albersen, Maarten, Spiess, Philippe E., and Necchi, Andrea

Published
2021
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14. Kidney Transplantation after Rescue Allocation - the Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Muehlfeld, Anja, Antonia, Bouts, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Huüser, Norbert, and Heemann, Uwe

Published
2021
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22. Sling Surgery for Female Incontinence

Author

Sievert, Karl-Dietrich, Abufaraj, Mohammad, Kernig, Karoline, Dräger, Desiree-Luise, Blaganje, Mija, Hakenberg, Oliver, Mansy, Karim, Liedl, Bernhard, Tarcan, Tufan, and de Ridder, Dirk

Published
2018
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23. Effectiveness of Adjuvant Chemotherapy After Radical Cystectomy for Locally Advanced and/or Pelvic Lymph Node–Positive Muscle-invasive Urothelial Carcinoma of the Bladder: A Propensity Score–Weighted Competing Risks Analysis

Author

Vetterlein, Malte W., Seisen, Thomas, May, Matthias, Nuhn, Philipp, Gierth, Michael, Mayr, Roman, Fritsche, Hans-Martin, Burger, Maximilian, Novotny, Vladimir, Froehner, Michael, Wirth, Manfred P., Protzel, Chris, Hakenberg, Oliver W., Roghmann, Florian, Palisaar, Rein-Jüri, Noldus, Joachim, Pycha, Armin, Bastian, Patrick J., Trinh, Quoc-Dien, Xylinas, Evanguelos, Shariat, Shahrokh F., Rink, Michael, Chun, Felix K.-H., Dahlem, Roland, Fisch, Margit, and Aziz, Atiqullah

Published
2018
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24. Effect of Hospital and Surgeon Case Volume on Perioperative Quality of Care and Short-term Outcomes After Radical Cystectomy for Muscle-invasive Bladder Cancer: Results From a European Tertiary Care Center Cohort

Author

Bartsch, Georg, Brookman-May, Sabine, Buchner, Alexander, Durschnabel, Melanie, Ellinger, Jörg, Froehner, Michael, Georgieva, Galia, Gördük, Murat, Grimm, Marc-Oliver, Hadaschik, Boris, Haferkamp, Axel, Hakenberg, Oliver W., Hartmann, Florian, Herrmann, Edwin, Hertle, Lothar, Hohenfellner, Markus, Janetschek, Georg, Kraischits, Nicole, Krausse, Annerose, Lusuardi, Lukas, Michel, Maurice S., Moritz, Rudolf, Müller, Stefan C., Novotny, Vladimir, Nuhn, Philipp, Pahernik, Sascha, Palisaar, Rein-Jüri, Ponholzer, Anton, Protzel, Chris, Roigas, Jan, Schmid, Marianne, Schramek, Paul, Seitz, Christian, Sikic, Danijel, Stief, Christian G., Syring, Isabella, Vallo, Stefan, Wagenlehner, Florian M., Weidner, Wolfgang, Wirth, Manfred P., Vetterlein, Malte W., Meyer, Christian P., Leyh-Bannurah, Sami-Ramzi, Mayr, Roman, Gierth, Michael, Fritsche, Hans-Martin, Burger, Maximilian, Keck, Bastian, Wullich, Bernd, Martini, Thomas, Bolenz, Christian, Pycha, Armin, Hanske, Julian, Roghmann, Florian, Noldus, Joachim, Bastian, Patrick J., Gilfrich, Christian, May, Matthias, Rink, Michael, Chun, Felix K.-H., Dahlem, Roland, Fisch, Margit, and Aziz, Atiqullah

Published
2017
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26. Clinical Outcomes of Perioperative Chemotherapy in Patients With Locally Advanced Penile Squamous-Cell Carcinoma: Results of a Multicenter Analysis

Author

Necchi, Andrea, Pond, Gregory R., Raggi, Daniele, Ottenhof, Sarah R., Djajadiningrat, Rosa S., Horenblas, Simon, Khoo, Vincent, Hakenberg, Oliver W., Draeger, Desiree, Protzel, Chris, Heidenreich, Axel, Haidl, Friederike, Eigl, Bernie J., Nappi, Lucia, Matsumoto, Kazumasa, Vaishampayan, Ulka, Woods, Michael E., Salvioni, Roberto, Nicolai, Nicola, Catanzaro, Mario, Giannatempo, Patrizia, Geynisman, Daniel M., Preto, Mirko, Xylinas, Evanguelos, Milowsky, Matthew I., De Placido, Sabino, Di Lorenzo, Giuseppe, and Sonpavde, Guru

Published
2017
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27. The Use of Neoadjuvant Chemotherapy in Patients With Urothelial Carcinoma of the Bladder: Current Practice Among Clinicians

Author

Martini, Thomas, Gilfrich, Christian, Mayr, Roman, Burger, Maximilian, Pycha, Armin, Aziz, Atiqullah, Gierth, Michael, Stief, Christian G., Müller, Stefan C., Wagenlehner, Florian, Roigas, Jan, Hakenberg, Oliver W., Roghmann, Florian, Nuhn, Philipp, Wirth, Manfred, Novotny, Vladimir, Hadaschik, Boris, Grimm, Marc-Oliver, Schramek, Paul, Haferkamp, Axel, Colleselli, Daniela, Kloss, Birgit, Herrmann, Edwin, Fisch, Margit, May, Matthias, and Bolenz, Christian

Published
2017
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31. Age-dependent effects of the β3 adrenoceptor agonist CL316,243 on human and rat detrusor muscle strips.

Author

Petereit, Charlotte, Porath, Katrin, Rackow, Simone, Kernig, Karoline, Hakenberg, Oliver W., Köhling, Rüdiger, and Kirschstein, Timo

Subjects
RANK correlation (Statistics), MIDDLE age, OVERACTIVE bladder, BETA adrenoceptors, RATS, SMOOTH muscle, ALPHA adrenoceptors
Abstract

Motility of detrusor smooth muscle includes adrenergic relaxation and cholinergic contraction. Since the latter may be deregulated in overactive bladder (OAB) pathophysiology, anticholinergics are the standard therapy but occasionally less tolerated due to side effects such as dry mouth and constipation. β3 adrenoceptor agonists also alleviate OAB symptoms by relaxing the detrusor muscle. Their age dependence, however, is far from understood. To address this issue, we induced contractions with KCl (60 mM) and carbachol (from 10 nM to 100 μM) in the presence of the β3 adrenoceptor agonist CL316,243 (from 0.1 to 10 μM) in both human and rat muscle strips. Our results confirmed that both contractions were attenuated by β3 adrenoceptor activation in both species, but with differing age dependence. In humans, specimens from mid-life subjects showed a significantly more pronounced effect of CL316,243 in attenuating carbachol-induced contractions than those from aged subjects (Cohen's d of maximal attenuation: 1.82 in mid-life versus 0.13 in aged) without altering EC50. Conversely, attenuation of KCl responses by CL316,243 increased during ageing (Spearman correlation coefficient = -0.584, P<0.01). In rats, both KCl- and carbachol-induced contractions were significantly more attenuated by CL316,243 in samples from adolescent as compared to aged samples. Immunohistochemistry in human detrusor sections proved β3 adrenoreceptor abundance to remain unaltered during ageing. In conclusion, our findings suggest differential age-dependent changes in human β3 adrenoceptor-dependent attenuation of detrusor contraction in terms of electromechanical versus pharmacomechanical coupling; they may help understand the differential responsiveness of OAB patients to β3 agents. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Prospective evaluation of sexual health following radical cystectomy due to bladder cancer.

Author

Nolting, Julia, Nitzsche, Romy, Kiss, Bernhard, Hakenberg, Oliver W, and Schneidewind, Laila

Subjects
SEXUAL health, PEARSON correlation (Statistics), BLADDER cancer, OLDER women, CYSTECTOMY
Abstract

Background: There is a lack of data concerning sexual health following open radical cystectomy (RC), especially in elderly patients and women. Aim: To describe sexual health and its impact on general health as well as survival in patients undergoing standard open RC for the treatment of bladder cancer (BC). Due to limited data, subgroup analysis for elderly patients and women was performed. Methods: A prospective noninterventional clinical study was performed evaluating sexual health in RC with any kind of urinary diversion due to BC with a follow-up of 12 months after RC. The study was approved by the local ethics review board (A 2021-0175) and was registered at the German Clinical Trial Register (DRKS00026255). Assessment of sexual health was done with the following validated questionnaires: EORTC QLQ-C30 (for quality of life; European Organisation for Research and Treatment of Cancer), EORTC SH22 (for sexual health), and IIEF-5 (5-item International Index of Erectile Function). Outcomes: The standard measurements of EORTC QLQ-C30, EORTC SH22, and IIEF-5 as well as overall survival. Results: Thirty-two patients participated in the study with a mean age of 71.5 years (SD, 9.7): 25 (78.1%) were male and 7 (21.9%) were female. Overall there is a heterogenic picture for sexual health in the study population, but sexual satisfaction is significantly higher prior to surgery while the importance of a sex life stays high and stable. Interestingly, the general health score is significantly correlated to sexual satisfaction (Pearson's correlation; r = 0.522, P =.002) preoperatively but not following surgery: r = 0.103 (P =.665) after 3 months, r = 0.478 (P =.052) after 6 months, r = 0.276 (P =.302) after 9 months, and r = 0.337 (P =.202) after 12 months. The importance of a sex life is still essential for the patients, especially when recovering from RC; nearly the same can be reported for elderly patients. Unfortunately, the data for women are too limited to report robust results. Clinical Implications: Evaluation, advice, and monitoring of sexual health must be integrated into clinical practice, particularly in women. Strengths and Limitations: At least to our knowledge, this is the first systematic prospective evaluation of sexual health in patients with BC receiving RC. Due to the small sample size, there is a risk of selection bias. Conclusion: Sexual health is important for patients with BC receiving RC, and it is an essential part of quality of life, especially in elderly patients. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Kidney Transplantation after Rescue Allocation - The Eurotransplant Experience

Author

Assfalg, Volker, Miller, Gregor, Stocker, Felix, van Meel, Marieke, Groenevelt, Tiny, Tieken, Ineke, Ankerst, Donna, Renders, Lutz, Novotny, Alexander, Hartmann, Daniel, Jell, Alissa, Rahmel, Axel, Wahba, Roger, Mühlfeld, Anja, Bouts, Antonia, Ysebaert, Dirk, Globke, Brigitta, Jacobs-Tulleneers-Thevissen, Daniel, Piros, László, Stippel, Dirk, Heller, Katharina, Eisenberger, Ute, van Laecke, Steven, Weimer, Rolf, Rosenkranz, Alexander R., Berger, Stefan, Fischer, Lutz, Kliem, Volker, Vondran, Florian, Sester, Urban, Schneeberger, Stefan, Harth, Ana, Kuypers, Dirk, Függer, Reinhold, Arnol, Miha, Christiaans, Maarten, Weinmann-Menke, Julia, Krüger, Bernd, Hilbrands, Luuk, Banas, Bernhard, Hakenberg, Oliver, Minnee, Robert, Schwenger, Vedat, Heyne, Nils, van Zuilen, Arjan, Reindl-Schwaighofer, Roman, Lopau, Kai, Hüser, Norbert, Heemann, Uwe, Huüser, Norbert, Surgery, Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Paediatric Nephrology, ARD - Amsterdam Reproduction and Development, Interne Geneeskunde, MUMC+: MA Nefrologie (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, Pediatrics, Basic (bio-) Medical Sciences, and Diabetes Pathology & Therapy

Subjects
Waiting time, kidney, PREDICTOR, medicine.medical_specialty, Tissue and Organ Procurement, Eurotransplant, medicine.medical_treatment, Medizin, Outcome analysis, deceased donor renal transplantation, COLD ISCHEMIA TIME, surgery, All institutes and research themes of the Radboud University Medical Center, Internal medicine, DIALYSIS, Medicine and Health Sciences, Humans, Medicine, standard allocation, FRAILTY, Kidney transplantation, Dialysis, Retrospective Studies, RISK, GRAFT FAILURE, Transplantation, Deceased donor, rescue allocation, business.industry, MORTALITY, Incidence (epidemiology), Graft Survival, algorithms Eurotransplant kidney allocation system, ASSOCIATION, medicine.disease, Kidney Transplantation, Tissue Donors, Confidence interval, Eurotransplant senior program, RECIPIENTS, Treatment Outcome, SURVIVAL, Human medicine, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business
Abstract

BACKGROUND: At Eurotransplant (ET), kidneys are transferred to "rescue allocation" (RA), whenever the standard allocation (SA) algorithms Eurotransplant Kidney Allocation System (ETKAS) and Eurotransplant Senior Program (ESP) fail. We analyzed the outcome of RA. METHODS: Retrospective patient clinical and demographic characteristics association analyses were performed with graft outcomes for 2422 recipients of a deceased donor renal transplantation (DDRT) after RA versus 25 481 after SA from 71 centers across all ET countries from 2006 to 2018. RESULTS: Numbers of DDRTs after RA increased over the time, especially in Germany. RA played a minor role in ESP versus ETKAS (2.7% versus 10.4%). RA recipients and donors were older compared with SA recipients and donors, cold ischemia times were longer, waiting times were shorter, and the incidence of primary nonfunction was comparable. Among ETKAS recipients, HLA matching was more favorable in SA (mean 3.7 versus 2.5). In multivariate modeling, the incidence of graft loss in ETKAS recipients was reduced in RA compared with SA (subdistribution hazard ratio, 0.80; 95% confidence interval [0.70-0.91], P

Published
2022

35. Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis

Author

Beyer, Ulrike, Brand, Frank, Martens, Helge, Weder, Julia, Christians, Arne, Elyan, Natalie, Hentschel, Bettina, Westphal, Manfred, Schackert, Gabriele, Pietsch, Torsten, Hong, Bujung, Krauss, Joachim K., Samii, Amir, Raab, Peter, Das, Anibh, Dumitru, Claudia A., Sandalcioglu, I. Erol, Hakenberg, Oliver W., Erbersdobler, Andreas, Lehmann, Ulrich, Reifenberger, Guido, Weller, Michael, Reijns, Martin A. M., Preller, Matthias, Wiese, Bettina, Hartmann, Christian, and Weber, Ruthild G.

Published
2017
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37. Impact of photodynamic diagnosis-assisted transurethral resection of bladder tumors on the prognostic outcome after radical cystectomy: results from PROMETRICS 2011

Author

May, Matthias, Fritsche, Hans-Martin, Vetterlein, Malte W., Bastian, Patrick J., Gierth, Michael, Nuhn, Philipp, Aziz, Atiqullah, Fisch, Margit, Stief, Christian G., Hohenfellner, Markus, Wirth, Manfred P., Novotny, Vladimir, Hakenberg, Oliver W., Noldus, Joachim, Gilfrich, Christian, Bolenz, Christian, Burger, Maximilian, Brookman-May, Sabine D., Bartsch, G, Bolenz, C, Buchner, A, Chun, FK, Dahlem, R, Durschnabel, M, Ellinger, J, Froehner, M, Georgieva, G, Gördük, M, Grimm, MO, Grimm, T, Hadaschik, B, Haferkamp, A, Hartmann, F, Herrmann, E, Janetschek, G, Karl, A, Keck, B, Kraischits, N, Krausse, A, Lusuardi, L, Martini, T, Mayr, R, Michel, MS, Moritz, R, Müller, SC, Nuhn, P, Pahernik, S, Palisaar, RJ, Ponholzer, A, Protzel, C, Pycha, A, Rink, M, Roghmann, F, Roigas, J, Schmid, M, Schramek, P, Seitz, C, Shariat, SF, Sikic, D, Syring, I, Vallo, S, Wagenlehner, FM, Wullich, B, and PROMETRICS 2011 Research Group

Published
2017
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41. Peri‐operative allogeneic blood transfusion does not adversely affect oncological outcomes after radical cystectomy for urinary bladder cancer: a propensity score‐weighted European multicentre study

Author

Vetterlein, Malte W., Gild, Philipp, Kluth, Luis A., Seisen, Thomas, Gierth, Michael, Fritsche, Hans‐Martin, Burger, Maximilian, Protzel, Chris, Hakenberg, Oliver W., von Landenberg, Nicolas, Roghmann, Florian, Noldus, Joachim, Nuhn, Philipp, Pycha, Armin, Rink, Michael, Chun, Felix K.‐H., May, Matthias, Fisch, Margit, Aziz, Atiqullah, Bartsch, G, Bolenz, C, Brookman‐May, S, Buchner, A, Durschnabel, M, Ellinger, J, Froehner, M, Georgieva, G, Gilfrich, C, Gördük, M, Grimm, MO, Hadaschik, B, Haferkamp, A, Hartmann, F, Herrmann, E, Hertle, L, Hohenfellner, M, Janetschek, G, Keck, B, Kraischits, N, Krausse, A, Lusuardi, L, Martini, T, Michel, MS, Moritz, R, Müller, SC, Novotny, V, Pahernik, S, Palisaar, RJ, Ponholzer, A, Roigas, J, Schmid, M, Schramek, P, Seitz, C, Sikic, D, Stief, CG, Syring, I, Traumann, M, Vallo, S, Wagenlehner, FM, Weidner, W, Wirth, MP, and Wullich, B

Published
2018
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42. Lifestyle aspects in a contemporary middle-European cohort of patients undergoing androgen deprivation therapy for advanced prostate cancer: data from the non-interventional LEAN study.

Author

Schmitz-Dräger, Bernd J., Bismarck, Ekkehardt, Grammenos, Dorothee, Ebert, Thomas, Starlinger, Roland, Ottillinger, Bertram, Goebell, Peter J., Mühlich, Stephan, Benderska-Söder, Natalya, and Hakenberg, Oliver

Subjects
FOOD habits, ANTIANDROGENS, LEUPROLIDE, PATIENT advocacy, NUTRITIONAL assessment, PHYSICAL activity, HEALTH behavior, QUESTIONNAIRES, PROSTATE tumors, BEHAVIOR modification, LONGITUDINAL method
Abstract

Androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with significant side effects. With the transition of PCa from a foudroyant course to a chronic disease, managing these side effects has become increasingly important. There is growing evidence that nutritional changes and physical activity are beneficial in these patients. Here we examine the impact of written patient information on the physical activity and dietary habits of PCa patients receiving ADT and behaviour changes between baseline and 1 year, in the open-label, non-interventional LEAN study. In total, 959 patients with advanced hormone-sensitive PCa requiring ADT with the Leuprorelin Sandoz® implant were included from January 2014 to July 2015 and followed for ≥ 12 months. At the start of the study, urologists received a questionnaire concerning the written information provided to patients regarding their disease, patient advocacy groups, diet and physical activity. Patients received a questionnaire on their dietary habits and physical activity at the start and end of the study. Urologists from 147 study centres and 540 patients responded to the questionnaires. While 69 % of these patients received disease-specific information, only 30 % and 17 % received information regarding nutrition and physical activity, respectively. The majority of urologists estimate that their patients rarely or never follow guidance on nutrition or physical activity, yet > 90 % of patients indicate they would make use of this information, if provided. Few patients showed behavioural changes between baseline and 1 year without evident differences between patients that received information and those that did not. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Prediction of Treatment Response and Survival with Chemotherapy for Metastatic Penile Cancer by the Modified Glasgow Prognostic Score.

Author

Draeger, Desiree-Louise, Groh, Sophie, Buchholz, Tim, Woehl, Maria, Nolting, Julia, and Hakenberg, Oliver W.

Subjects
PENILE cancer, GLASGOW Coma Scale, PROPORTIONAL hazards models, METASTASIS, PROGRESSION-free survival, PROGNOSIS
Abstract

Purpose: There is increasing evidence that a persistent systemic inflammatory response predicts lower survival in patients with malignant disease. The modified Glasgow Prognostic Score (mGPS) is defined by a combination of elevated C-reactive protein (CRP) (>10 mg/L) and hypoalbuminemia (<35 g/L). It is considered as an independent prognostic marker in several organ malignancies. The aim of this study was to investigate the value of mGPS in metastatic penile carcinoma in predicting treatment response and survival. Methods: One hundred and fifty-six patients with penile carcinoma treated with chemotherapy were included in this retrospective study. The mGPS before chemotherapy was classified into 3 groups (mGPS 0 [CRP <10, any albumin], mGPS 1 [CRP >10 mg/L, albumin >35 g/L], and mGPS 2 [CRP >10 mg/L, albumin <35 g/L]). Overall survival and disease-free survival were calculated by Kaplan-Meier analysis and chemotherapy toxicity by CTC criteria. Univariate Cox proportional hazards models were calculated to estimate the effect of each predictor on OS and DFS. Results: Survival was significantly different in the 3 mGPS classes, with mGPS 0 patients showing the best treatment response and survival. Univariate analysis showed that mGPS (p < 0.0001), tumor stage (p = 0.004), and venous and lymphatic invasion (p = 0.011) were factors independently associated with prognosis. The response to chemotherapy differed significantly between mGPS groups (mGPS 0, 36/51 [71%]; mGPS 1, 24/70 [34%]; mGPS 2, 9/35 [26%], p = 0.03 and p = 0.37, respectively). mGPS was significantly associated with chemotherapy-associated toxicity, with treatment adaptation (p < 0.01) and toxicity-related deaths (p = 0.028). Conclusions: Systemic inflammatory response and nutritional status as expressed by the mGPS are independent predictors of treatment response, chemotherapy-associated toxicity, and survival in metastatic penile carcinoma. In addition to other known pathological markers of tumor aggressiveness, the mGPS can be used as a clinical predictor of prognosis. [ABSTRACT FROM AUTHOR]

Published
2023
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48. ERBB2 Amplification as a Predictive and Prognostic Biomarker in Upper Tract Urothelial Carcinoma.

Author

Zimpfer, Annette, Kdimati, Said, Mosig, Melanie, Rudolf, Henrik, Zettl, Heike, Erbersdobler, Andreas, Hakenberg, Oliver W., Maruschke, Matthias, and Schneider, Björn

Subjects
BLADDER tumors, TISSUE arrays, DISEASE progression, PLATINUM compounds, PREDICTIVE tests, EPIDERMAL growth factor receptors, IMMUNOHISTOCHEMISTRY, REGRESSION analysis, GENE expression, FLUORESCENCE in situ hybridization, SURVIVAL analysis (Biometry), TUMOR markers, GENE amplification, SENSITIVITY & specificity (Statistics), PROGRESSION-free survival, OVERALL survival
Abstract

Simple Summary: Upper tract urothelial carcinomas (UTUCs) occur in about 5–10% of all urothelial carcinomas and are frequently discovered in high-stage disease. We aimed to evaluate human epidermal growth factor receptor 2 (ERBB2) protein expression and ERBB2 amplification in UTUCs according to the American Society of Clinical Oncology/College of American Pathologists guidelines for gastric carcinoma, revealing an obvious higher rate of ERBB2 overexpression (41.8%) in contrast to the relatively low frequency of ERBB2 amplification (10.5%) in UTUCs. Correlation and survival analyses show that ERBB2 overexpression and amplification were linked with high-grade and high-stage tumors and with tumor progression. The results suggest that ERBB2 is a biomarker for progression in UTUCs. As previously shown, ERBB2 amplification is infrequent. However, the small number of patients diagnosed with ERBB2-amplified UTUC might benefit from ERBB2-targeted therapy. For the reliable detection of rare ERBB2-amplified UTUC, simultaneous immunohistochemical and cytogenetic ERBB2 analysis is recommended. Upper tract urothelial carcinomas (UTUCs) occur in about 5–10% of all urothelial carcinomas and are frequently discovered in high-stage disease. We aimed to evaluate human epidermal growth factor receptor 2 (ERBB2) protein expression immunohistochemically and ERBB2 amplification in UTUCs by fluorescence in situ hybridization, applying a tissue microarray technique. ERBB2 overexpression and ERBB2 amplification were defined according to the recommendations of the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) for breast cancer and gastric carcinoma (GC), revealing scores of 2+ and 3+ in 10.2% and 41.8% of UTUCs, respectively. The performance parameters showed obviously higher sensitivity of ERBB2 immunoscoring according to the ASCO/CAP criteria for GC. ERBB2 amplification was detected in 10.5% of UTUCs. ERBB2 overexpression was more likely to be found in high-grade tumors and was associated with tumor progression. Univariable Cox regression analysis revealed a significantly lower progression-free survival (PFS) in cases with ERBB2 immunoscores of 2+ or 3+ according to the ASCO/CAP guidelines for GC. UTUCs with ERBB2 amplification showed a significantly shorter PFS in the multivariable Cox regression analysis. Irrespective of their ERBB2 status, patients with UTUC treated with platin showed a significantly lower PFS than UTUC patients who had not received any platin-based therapy. In addition, UTUC patients with a normal ERBB2 gene status who had not received platin-based therapy showed significantly longer overall survival. The results suggest that ERBB2 is a biomarker for progression in UTUCs and may define a distinct subgroup of UTUCs. As previously shown, ERBB2 amplification is infrequent. However, the small number of patients diagnosed with ERBB2-amplified UTUC might benefit from ERBB2-targeted cancer therapy. In clinical–pathological routine diagnostics, the determination of ERBB2 amplification is an established method in some defined entities and also successful in small samples. Still, the simultaneous use of ERBB2 immunohistochemistry and ERBB2 in situ hybridization would be important in order to record the low rate of amplified UTUC cases as completely as possible. [ABSTRACT FROM AUTHOR]

Published
2023
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49. The Goal of Achieving High-Quality Surgical First-Line Therapy in Patients with Penile Cancer Is Important; However, Some Collective Efforts Are Still Required in Order to Reach It. Comment on Brassetti et al. Combined Reporting of Surgical Quality and Cancer Control after Surgical Treatment for Penile Tumors with Inguinal Lymph Node Dissection: The Tetrafecta Achievement. Curr. Oncol. 2023, 30 , 1882–1892

Author

May, Matthias, Lebentrau, Steffen, Ayres, Ben, Albersen, Maarten, Protzel, Chris, Chahoud, Jad, Brouwer, Oscar R., Pettaway, Curtis A., Pagliaro, Lance C., Necchi, Andrea, Watkin, Nick, Hakenberg, Oliver W., and Spiess, Philippe E.

Subjects
PENILE cancer, LYMPH nodes, SENTINEL lymph nodes, UROLOGY, CANCER
Published
2023
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50. Concomitant vs Staged Therapeutic Inguinal Lymphadenectomy in Clinically Node Positive Penile Squamous Cell Carcinoma: Does It Make a Difference?

Author

Huelster, Heather L., Chang, Andrew, Rose, Kyle M., Bandini, Marco, Albersen, Maarten, Roussel, Eduard, Chipollini, Juan, Yao Zhu, Ding-Wei Ye, Ornellas, Antonio A., Catanzaro, Mario, Marandino, Laura, Pederzoli, Filippo, Hakenberg, Oliver W., Heidenreich, Axel, Haidl, Friederike, Watkin, Nick, Ager, Michael, Ahmed, Mohamed E., and Karnes, Jeffrey R.

Subjects
LYMPHADENECTOMY, PENILE cancer, SQUAMOUS cell carcinoma, LYMPH node surgery, HEALTH facilities, TUMOR surgery, OVERALL survival
Abstract

Purpose: Inguinal lymph node dissection within 3 months of primary tumor resection in penile cancer has been associated with longer recurrence-free and cancer-specific survival. However, the optimal timing and effect of lymphadenectomy performed concurrently at the time of primary lesion management on oncologic outcomes in clinically lymph node positive penile squamous cell carcinoma remains unknown. Materials and Methods: An international, multicenter cohort of 966 penile cancer cases was queried for penile squamous cell carcinoma management after the year 2000, clinically lymph node positive status, and performance of penile surgery and inguinal lymph node dissection. Cohorts were stratified as concomitant if inguinal lymph node dissection and penile surgery occurred on the same date or staged when inguinal lymph node dissection was performed after penile resection. Rates and patterns of penile squamous cell carcinoma recurrence were reported. Distant recurrence-free, cancer-specific, and overall survival were estimated using Kaplan-Meier analyses and groups compared with log-rank testing. Results: Of 253 contemporary men with clinically lymph node positive penile squamous cell carcinoma, 96 (38%) underwent concomitant inguinal lymph node dissection and 157 (62%) had inguinal lymph node dissection performed in a staged manner. Penile cancer was most likely to recur distantly (19%) followed by in the groin (14%) or pelvis (5%). There were no differences in distant recurrence-free, cancer-specific, or overall survival between management strategies. Multivariable analysis adjusting for stage, treatment center, and perioperative chemoradiation also demonstrated no recurrence-free, cancer-specific, or overall survival benefit between management strategies. Conclusions: Inguinal lymph node dissection performed concurrently with excision of the penile tumor for clinically node positive penile squamous cell carcinoma is not associated with differences in recurrence-free, cancer-specific, or overall survival compared to staged lymph node dissection. [ABSTRACT FROM AUTHOR]

Published
2023
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