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Studies in vitro the protective effect of elevated copper zinc superoxide dismutase on the prevention of diabetes-associated embryopathy using mouse models. Glucose levels in pregnant mice and superoxide dismutase activity in embryos; Amelioration of diabetes-induced embryopathies.

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: ObjectivesRipening of the cervix with a Foley catheter commonly results in cervical dilatation without contractions. We examined the outcome of labour in women who underwent induction of labour using a Foley catheter, followed by either 1. early amniotomy, or 2. augmentation of labour by oxytocin and late amniotomy: DesignProspective randomised clinical trial: SettingLabour and delivery ward of a university teaching hospital: ParticipantsPregnant women ≥38 weeks of a singleton gestation, who had had no prior caesarean section: MethodsAll women underwent cervical ripening using a Foley catheter. Following removal of the catheter, women were randomly assigned to either early (n = 80) or late amniotomy (n = 88).Main outcome measures Comparison of mode of delivery and duration of labour between the two groups: ResultsThe rate of caesarean section was significantly higher in the early amniotomy group compared with the late amniotomy group (25% vs 7.9%; relative risk 1.74; 95% CI 1.3 – 2.34). The increase in caesarean section rate was due primarily to dystocia (15% vs 3.3%; relative risk 1.8; 95% CI 1.32 – 2.45). When excluding caesarean deliveries, no significant difference was found in duration of labour between the groups (8.3 hours (3.8) vs 7.7 hours (2.9)): ConclusionsIn women who undergo cervical ripening with a Foley catheter, augmentation of labour by oxytocin followed by amniotomy during active labour results in a lower rate of caesarean delivery for dystocia [ABSTRACT FROM AUTHOR]