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The volumes on'psychotropic substances'in the Handbook of Experimental Phar­ macology series clearly show that the classical concept of this discipline has become too narrow in recent years. For instance, what substances are psychotropic is determined not by the criteria of the animal trial, i.e. by experimental pharmacology, but by their action on the psy­ che, which in the final analysis is only accessible to us in man. Psychotropic substances force experimental pharmacology (and thus also this Handbook) outside its tradition­ allimits, which have essentially depended on animal studies. The antipsychotics and antidepressants were not discovered in animal ex­ periments, but by chance (or more precisely, by clinical empiricism). Experienced psy­ chiatrists trained in the observation of patients recognised the efficacy of drugs, the beneficial effect of which nobody had dreamed of before: DELAY and DENICKER in the case of chlorpormazine, KLINE in the case of the monoamine oxidase inhibitors and KUHN in the case of imipramine. It was only after these discoveries that the pharma­ cologists developed experimental models of the psychoses in animal experiments. However, even today we still do not know with certainty which of the effects shown in animals is relevant for the clinical effect despite the vast abundance of individual investigations. For many years, this uncertainty led to the testing of antipsychotics (e.g. of the neuroleptic type) in models which actually produced the undesired effects.

Cornea, edited by Drs. Krachmer, Mannis & Holland, is the only truly comprehensive clinical reference available that covers external disease, anterior uveitis, and the expanding range of contemporary corneal surgery. In this Third Edition, state-of-the-art coverage, 25 brand-new chapters, and 45 new videos provide expert guidance on performing femtosecond-assisted penetrating keratoplasty, DSAEK, deep anterior lamellar keratoplasty, and many other cutting-edge techniques. Plus, you'll have easy access to the complete contents and illustrations online at expertconsult.Overcome any clinical challenge related to the cornea, external disease, anterior uveitis, and the expanding range of contemporary corneal surgery with the most complete, authoritative guidance source available.Get superb visual guidance with exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs.Access the complete contents and illustrations online at expertconsult.Make optimal use of Anterior Segment OCT to plan and choose treatment options and assess post-operative recovery.Master the latest surgical techniques—including femtosecond-assisted penetrating keratoplasty, DSAEK, and deep anterior lamellar keratoplasty—thanks to 25 brand-new chapters and 45 new videos on DVD (a total of 3 hours running time).Understand the full spectrum of corneal diseases with coverage of the new corneal dystrophy classification that incoporates current genetic, clinical, and pathologic information.

The late Arthur Rook established the Textbook of Dermatology as the most comprehensive work of reference available to the dermatologist. Covering all aspects of skin disease from basic science through pathology and epidemiology to clinical practice, the text is recognized for its unparalleled coverage of diagnosis. Hailed by reviewers as'a thorough, modern masterpiece'and'the best textbook of dermatology in the world', and trusted by dermatologists around the world for accurate and comprehensive coverage, this clinical classic is the definitive source of information for all dermatologists. The new edition of this venerable classic extends the standard of excellence to include: All-new coverage of cosmetic dermatology and sexually transmitted diseases More material on evidence-based dermatology Increased coverage of dermoscopy More emphasis on therapeutics throughout the set More contributions from a greater variety of international experts New page design with larger illustrations for more immediate recognition The 8th Edition marks the debut of the online edition of Rook's Textbook of Dermatology, allowing users the fastest possible access to the full range of knowledge on all known dermatological conditions. With fully searchable text and a fully searchable bank of more than 3,300 downloadable images, this online version puts specific information at your fingertips - when and where you need it - and is free with purchase of the four-volume set. The person-specific access code travels with you, not your computer, so you can check with Rook from any location. With the online version, you can: Search across all four volumes simultaneously Search all images separately Download images into presentations Link directly to references via a range of sources Rook's Textbook of Dermatology, in print and now online, provides a reliable, constant companion for all dermatologists.

Title from e-book title screen (viewed on April 7, 2005)

Title from e-book title screen (viewed on April 7, 2005)

Title from e-book title screen (viewed on April 7, 2005)

Title from e-book title screen (viewed on April 7, 2005)

Title from e-book title screen (viewed on April 8, 2005)

Title from e-book title screen (viewed on April 12, 2005)

Title from e-book title screen (viewed on April 7, 2005)

The late Arthur Rook established the Textbook of Dermatology as the most comprehensive work of reference available to the dermatologist and it enjoys instant name recognition. Each subsequent edition has been expanded as the subject has developed and the book remains the ultimate source of clinical information for the trainee and practising dermatologist alike. Rook's Textbook of Dermatology covers all aspects of skin disease from basic science through pathology and epidemiology to clinical practice. Long recognized for its unparalleled coverage of diagnosis, this clinical classic earned its reputation as a definitive source of information. New features of this Seventh Edition include: Two new Editors, Neil Cox and Christopher Griffiths, join the team Every chapter is updated and several are completely rewritten from scratch Completely new chapter on AIDS and the Skin Traditional emphasis on diagnosis preserved More coverage of treatment in each of the disease-specific chapters

Clinical Ocular Pharmacology, Second Edition covers the diagnostic and therapeutic clinical procedures in the administration of drugs to the eye. This book is organized into five parts encompassing 35 chapters that evaluate the basic pharmacologic principles that govern the different types of ophthalmic drugs. It addresses the pharmacologic agents useful in the diagnosis and treatment of ocular diseases. Some of the topics covered in the book are the basic science of ocular pharmacology; clinical administration of ocular drugs; drugs affecting the autonomic nervous system; types of local anesthetics; review of anti-inflammatory drugs; and examination of inhibitors of aqueous formation. Other parts deal with the development of contact lens solution in clinical practice and the pharmacologic management of strabismus. These topics are followed by discussions of the legal basis of using drugs in optometry and the systemic effects of ocular drugs. The concluding part is devoted to the diseases of the optic nerve. The book can provide useful information to doctors, optometrists, pediatricians, students, and researchers.

A wealth of information and its clear organization make this survey of cutaneous drug reactions an indispensable reference source for the dermatologist and any physician prescribing drugs. It is the only publication which offers a systematic approach to the whole therapeutic armamentarium, as well as to the signs and symptoms affecting skin, mucous membranes, nails and hair. The information, documented by 5600 references, is presented in tabular form to allow quick location of needed data. Convenient indexes permit the user to trace either the side effects of specific drugs and their frequency or the possible drug causes of cutaneous reactions. The drug index contains both generic and brand names. Now entirely in English, this expanded and updated edition is easy to use and serves as both a practical diagnostic aid and an important source of references to the world literature. (A Karger''Publishing Highlights 1890–2015''title.)