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2. Geochemistry and tectonic controls of the effusive activity related with the ancestral Nevado del Ruiz volcano, Colombia

Author

H. Castillo, M. Alvarán, L. M. Toro, and C. Borrero

Subjects
Medium-K magmatism, adakitic signature, Late Pliocene –Early Pleistocene lavas, Villa María-Termales fault system, Nevado del Ruiz volcano., Geophysics. Cosmic physics, QC801-809
Abstract

In this paper, we discuss the geochemical aspects and the tectonic setting of the effusive activity between 2.0 to 1.0 Ma (the Ancestral Ruiz stage) of Nevado del Ruiz Volcano (NRV: 4° 50-55’N, 75° 14-20’ W, 5,390 masl), this volcano rises at the northernmost end of the Andean volcanic chain in the Cordillera Central of Colombia. Whole-rock geochemical data of andesitic to rhyodacitic samples from the different vents share specific characteristics: SiO2 = 56 -70.1 wt. %, relatively high MgO (1.1 - 8.1 wt. %) and medium K2O (1.06 - 4.36 wt. %) contents, low FeO/MgO ratios (typically less than 1,9), low fractioned rare earth element patterns with low Y and heavy rare earth elements contents, Sr commonly between 500 and 1,000 ppm and Ba up to 1,600 ppm. K/Rb ratios always show a negative correlation with SiO2 and Rb suggesting assimilation-fractional crystallization (AFC) mechanism. Rb/Sr, Ba/Sr and Rb/Ba ratios display a positive correlation with SiO2, typical of calcalkaline trends. The more acidic suites display the strongest adakitic character such as higher Sr, and lower HREE and Y contents. The N75oW Villa Maria –Termales fault system was the controller of the magma displacement aside of the main N-S volcanic axis during the Ancestral Ruiz stage. This tectonic control is evidenced by the distribution of the small effusive eruptions in monogenetic vents aligned parallel to the fault system, which were fed by lateral magma flow from the intermediate storaRuiz Volcano.

Published
2009

3. Geochemistry and tectonic controls of the effusive activity related with the ancestral Nevado del Ruiz volcano, Colombia

Author

C. Borrero, L. M. Toro, M. Alvarán, and H. Castillo

Subjects
magmatismo de k medio, firma adaquítica, lavas del plioceno tardío-pleistoceno temprano, falla de villa maría-termales, volcán nevado del ruiz, Geophysics. Cosmic physics, QC801-809
Abstract

Los aspectos geoquímicos y el marco tectónico de la actividad efusiva del período Ruiz Ancestral (2.0 a 1.0 Ma) del Volcán Nevado del Ruiz (VNR) son discutidos en este artículo. El VNR se localiza a 4° 50-55’ N y 75° 14-20’ W y se eleva a 5,390 msnm, en el sector más septentrional de la cadena volcánica andina en la Cordillera Central (Colombia). Datos químicos de roca total en muestras de andesitas y riodacitas de los diferentes sitios de emisión reportados comparten características específicas: SiO2 = 56 y 70.1% en peso, relativamente altos de MgO y medios de K2O; proporciones bajas de FeO/MgO: < 1.9 patrones de contenidos elementos de tierras raras poco fraccionados, bajo contenido de Y y REE pesadas; Sr entre 500 y 1,000 ppm y Ba hasta 1,600 ppm. Las proporciones de K/Rb muestran correlación negativa con SiO2 y con Rb, lo cual sugiere procesos de asimilación y cristalización fraccionada (ACF). Las proporciones de Rb/Sr, Ba/Sr y Rb/Ba muestran correlación positiva con SiO2, típicas de tendencias calcoalcalinas, sólo las suites más ácidas presentan un marcado carácter adaquítico. Durante el período Ruiz Ancestral, la falla de Villa María-Termales (N75ºW) controló el emplazamiento de magmas al occidente del eje volcánico N-S, evidenciado por el alineamiento paralelo de pequeños volcanes monogenéticos con el sistema de fallas, los cuales fueron alimentados lateralmente por flujos de magma desde el sistema de almacenamiento intermedio localizado entre 5 y 10 km por debajo de la posición del actual Volcán Nevado del Ruiz. doi: https://doi.org/10.22201/igeof.00167169p.2009.48.1.105

Published
2009
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4. Addressing the Use of Artificial Intelligence Tools in the Design of Visual Persuasive Discourses

Author

Ana Erika Ruiz-Arellano, David A. Mejía-Medina, Victor H. Castillo-Topete, María Berenice Fong-Mata, Ervey L. Hernández-Torres, Paloma Rodríguez-Valenzuela, and Enrique Berra-Ruiz

Subjects
Mechanical Engineering, visual persuasive communication, AI systems for design, design methods, Engineering (miscellaneous), Industrial and Manufacturing Engineering
Abstract

Artificial intelligence (AI) systems to generate images from natural language are a game changer in graphic design. However, in visual persuasive communication, the image is not just a drawing, but is the message itself. It arises from the need for understanding how AI systems could be adopted in the design of visual communication. Thus, this article presents a model that describes the theoretical–methodological factors present in the design of persuasive visual discourses, which arises from a qualitative study with an analysis of grounded theory from the opinion of experts in the essential areas for visual communication. Thus, we propose a model to guide the design process of persuasive messages throughout seven stages. Additionally, an analysis for contributing to the orderly and informed incorporation of technologies, techniques, and methods relevant to each stage is presented.

Published
2022
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7. Cardiopulmonary capacity in healthy subjects measured by direct method and field test

Author

Jaime A. Vásquez-Gómez, Ricardo Souza De Carvalho, Cesar P. Faundez-Casanova, Franklin H. Castillo-Retamal, Patricio J. Gatica-Mandiola, and Marcelo E. Castillo-Retamal

Subjects
lcsh:Immunologic diseases. Allergy, walking, cardiorespiratory fitness, lcsh:R, exercise test, lcsh:Medicine, lcsh:RC109-216, lcsh:RC581-607, oxygen consumption, predictive value of tests, lcsh:Infectious and parasitic diseases
Abstract

The six-minute walk test has been generally applied in people with pathologies and some studies have proposed models to predict maximum oxygen consumption. Our objective was to elaborate on an equation to predict the maximum oxygen consumption in the six-minute walking test for university students. A hundred and forty people participated in this study. The six-minute walking test was applied and after on a gradual exercise test was performed to determine the maximum oxygen consumption. A multivariate equation was developed and the analysis was done using the SPSS v.22 program (p < 0.05). The predictive model include gender, age, body mass index, distance performed and heart rate recovery (r = 0.83; p < 0.001). The equation fulfilled the assumptions of independence (p = 0.13), normality (p = 0.49) and homoscedasticity (p = 0.64). The Bland-Altman diagram indicated that there were no significant differences between the equation and the measurement of the maximum oxygen consumption (p = 0.89), with a confidence interval of 0.054 ml·kg·min-1 (95% CI [-0.72; 0.83]). The equation predicts the maximum oxygen consumption. It is suggested to evaluate university students considering biological and environmental differences between countries.

Published
2020

8. Hantavirus Prevalence in the IX Region of Chile

Author

Marlis Täger Frey, Pablo C. Vial, Constanza H. Castillo, Paula M. Godoy, Brian Hjelle, and Marcela G. Ferrés

Subjects
hantavirus seroprevalence, hantavirus asymptomatic infection, hantavirus epidemiology, hantavirus diagnosis, research, Chile, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

An epidemiologic and seroprevalence survey was conducted (n=830) to assess proportion of persons exposed to hantavirus in IX Region Chile, which accounts for 25% of reported cases of hantavirus cardiopulmonary syndrome. This region has three geographic areas with different disease incidences and a high proportion of aboriginals. Serum samples were tested for immunoglobulin (Ig) G antibodies by enzyme-linked immunosorbent assay against Sin Nombre virus N antigen by strip immunoblot assay against Sin Nombre, Puumala, Río Mamoré, and Seoul N antigens. Samples from six patients were positive for IgG antibodies reactive with Andes virus; all patients lived in the Andes Mountains. Foresting was also associated with seropositivity; but not sex, age, race, rodent exposure, or farming activities. Exposure to hantavirus varies in different communities of IX Region. Absence of history of pneumonia or hospital admission in persons with specific IgG antibodies suggests that infection is clinically inapparent.

Published
2003
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9. Haplotypic characterization of the olive ridley turtle (Lepidochelys olivacea) in northwest Mexico: the northernmost limit of its distribution

Author

S. Campista León, H. Castillo Ureta, L. I. Peinado Guevara, J. A. Beltrán Espinoza, J. G. Sánchez Zazueta, Centro de Investigación en Alimentación y Desarrollo (Ciad), Sinaloa, Mexico, J. R. Martín del Campo Flores, and I. Sosa Cornejo

Subjects
0106 biological sciences, mtdna, Endangered species, mtDNA, Control region (D–loop), Haplotypic and nucleotidic diversity, Olive ridley turtle, Population, Pantropical, olive ridley turtle, Lepidochelys olivacea, 010603 evolutionary biology, 01 natural sciences, 010605 ornithology, lcsh:Zoology, lcsh:QL1-991, education, Nature and Landscape Conservation, Ridley sea turtle, education.field_of_study, biology, Especie amenazada, ADNmt, Región de control (bucle–D), Diversidad haplotípica y nucleotídica, Tortuga golfina, Turtle (syntax), Forestry, endangered species, biology.organism_classification, Environmental variation, Geography, haplotypic and nucleotidic diversity, control region (d–loop), Animal Science and Zoology, Demographic expansion
Abstract

Caracterización haplotípica de la tortuga golfina (Lepidochelys olivacea) en el noroeste de México: el límite septentrional de su distribución La tortuga golfina (L. olivacea) tiene una distribución pantropical. En el Pacífico oriental, los límites oficiales de su zona de reproducción son la península de Baja California y el sur de Sinaloa, en México. La playa de Ceuta en Elota, Sinaloa, México ha servido de sitio de protección para L. olivacea durante más de tres decenios. En este estudio, se caracterizó genéticamente la población de L. olivacea de la playa de Ceuta. Concretamente, se amplificó un fragmento de 712 pb de la región de control del ADNmt de 32 tortugas golfinas. Se identificaron ocho haplotipos (siete tras reducir a ~468 pb) y se incluyeron dos haplotipos nuevos (Lo–T7 y Lo–T8) y cinco haplotipos que se habían identificado anteriormente en otras playas de anidación. El haplotipo Lo–T2 era dominante (~60 %) en las muestras: h = 0,6048 (± 0,0974) y π = 0,002212 (± 0,001504). Si bien este estudio se realizó en el límite septentrional de la zona de anidación de la tortuga golfina en el Pacífico oriental, el grupo estudiado presenta una diversidad genética moderada y pertenece a una población que, en la escala evolutiva, ha pasado recientemente por una expansión demográfica. Debido a que la tortuga golfina del Pacífico oriental se considera resiliente a la variación ambiental, es necesario estudiar las zonas de anidación en el noroeste de México., The olive ridley sea turtle (L. olivacea) has a pantropical distribution. In the Eastern Pacific, the official limits of its reproduction area are south of the Baja California peninsula and south of Sinaloa, Mexico. Ceuta beach in Elota, Sinaloa, Mexico, has served as a protection site for L. olivacea for over three decades. In this study, the L. olivacea population from Ceuta beach was genetically characterized. Specifically, a 712–bp fragment from the control region of mtDNA was amplified from 32 olive ridley turtles. Eight haplotypes (seven after cutting to ~468 bp) were identified, and these included two novel haplotypes (Lo–T7 and Lo–T8) and five haplotypes that were previously identified in other nesting beaches. The Lo–T2 haplotype was dominant (~60 %) in the samples: h = 0.6048 (± 0.0974) and π = 0.002212 (± 0.001504). Although this study was conducted in the northernmost limit of the olive ridley turtle nesting distribution in the eastern Pacific, the sampled group presents moderate genetic diversity and belongs to a population that, on an evolutionary scale, only recently underwent demographic expansion. Because the olive ridley turtle in the eastern Pacific is considered resilient to environmental variation, nesting area studies in northwest Mexico are necessary.

Published
2019

10. Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment DUNE Collaboration

Author

Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V. and Autiero, D. Azfar, F. Back, H. Back, J. J. and Backhouse, C. Baesso, P. Bagby, L. Bajou, R. and Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. and Barenboim, G. Barker, G. J. Barkhouse, W. Barnes, C. and Barr, G. Monarca, J. Barranco Barros, N. Barrow, J. L. and Bashyal, A. Basque, V. Bay, F. Alba, J. L. Bazo Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. and Bellettini, G. Bellini, V. Beltramello, O. Belver, D. and Benekos, N. Neves, F. Bento Berger, J. Berkman, S. and Bernardini, P. Berner, R. M. Berns, H. Bertolucci, S. and Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. and Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. and Bishai, M. Bitadze, A. Blake, A. Siffert, B. Blanco and Blaszczyk, F. D. M. Blazey, G. C. Blucher, E. Boissevain, J. and Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. and Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. and Boschi, T. Bostan, N. Bour, P. Boyd, S. B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. and Bremer, J. Brew, C. Brianne, E. Brice, S. J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. and Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. and Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. and Carini, G. Carlus, B. Carniti, P. Terrazas, I. Caro and Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. and Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Villanueva, A. Cervera Chalifour, M. Chang, C. and Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. and Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. and Childress, S. Chiriacescu, A. Cho, K. Choubey, S. and Christensen, A. Christian, D. Christodoulou, G. Church, E. and Clarke, P. Coan, T. E. Cocco, A. G. Coelho, J. A. B. and Conley, E. Conrad, J. M. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadon, J. I. and Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. Cussans, D. and Dabrowski, M. da Motta, H. Peres, L. Da Silva David, C. and David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. and De Almeida, R. M. Debbins, P. De Bonis, I. Decowski, M. P. de Gouvea, A. De Holanda, P. C. De Icaza Astiz, I. L. and Deisting, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. de Mello Neto, J. R. T. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V. De Vries, J. J. Dharmapalan, R. Dias, M. Diaz, F. Diaz, J. S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. and Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. J. and Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. and Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. and Dwyer, D. A. Dyshkant, A. S. Eads, M. Edmunds, D. and Eisch, J. Emery, S. Ereditato, A. Escobar, C. O. and Sanchez, L. Escudero Evans, J. J. Ewart, E. Ezeribe, A. C. and Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. Fernandez Menendez, P. Ferraro, F. and Fields, L. Filkins, A. Filthaut, F. Fitzpatrick, R. S. and Flanagan, W. Fleming, B. Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. and Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. and Gandhi, R. Gandrajula, R. Gao, S. Garcia-Gamez, D. and Garcia-Peris, M. A. Gardiner, S. Gastler, D. Ge, G. and Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. and Gibin, D. Gil-Botella, I. Girerd, C. Giri, A. K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. and Gomes, R. A. Bermeo, L. V. Gomez Fajardo, L. S. Gomez and Gonnella, F. Gonzalez-Cuevas, J. A. Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. and Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. Green, P. Green, S. and Greenler, L. Greenwood, M. Greer, J. Griffith, W. C. and Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. and Guenette, R. Guglielmi, A. Guo, B. Guthikonda, K. K. and Gutierrez, R. Guzowski, P. Guzzo, M. M. Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. and Haigh, J. Haiston, J. Hamernik, T. Hamilton, P. Han, J. and Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. and Hatcher, R. Hazen, E. Heavey, A. Heeger, K. M. Heise, J. and Hennessy, K. Henry, S. Morquecho, M. A. Hernandez and Herner, K. Hertel, L. Hesam, A. S. Hewes, J. Higuera, A. and Hill, T. Hillier, S. J. Himmel, A. Hoff, J. Hohl, C. and Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. and Hourlier, A. Howard, B. Howell, R. Huang, J. Huang, J. and Hugon, J. Iles, G. Ilic, N. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. K. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V. A. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. and Kudryavtsev, V. A. Kulagin, S. Kumar, J. Kumar, R. and Kuruppu, C. Kus, V. Kutter, T. Lambert, A. Lande, K. and Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. and LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann Lehnert, R. de Oliveira, M. A. Leigui Leitner, M. and Leyton, M. Li, L. Li, S. Li, S. W. Li, T. Li, Y. and Liao, H. Lin, C. S. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. and Lomidze, I. Long, K. Loo, K. Lorca, D. Lord, T. and LoSecco, J. M. Louis, W. C. Luk, K. B. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. MacFarland, D. Machado, A. A. and Machado, P. Macias, C. T. Macier, J. R. Maddalena, A. and Madigan, P. Magill, S. Mahn, K. Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. Manenti, L. Manly, S. and Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. and Marciano, W. Marfatia, D. Mariani, C. Maricic, J. and Marinho, F. Marino, A. D. Marshak, M. Marshall, C. and Marshall, J. Marteau, J. Martin-Albo, J. Martinez, N. and Caicedo, D. A. Martinez Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. and Mauri, N. Mavrokoridis, K. Mazza, R. Mazzacane, A. and Mazzucato, E. McCluskey, E. McConkey, N. McFarland, K. S. and McGrew, C. McNab, A. Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. Menary, S. Mendez, H. and Menegolli, A. Meng, G. Messier, M. D. Metcalf, W. Mewes, M. Meyer, H. Miao, T. Michna, G. Miedema, T. and Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. and Mineev, O. Miranda, O. G. Miryala, S. Mishra, C. S. and Mishra, S. R. Mislivec, A. Mladenov, D. Mocioiu, I. and Moffat, K. Moggi, N. Mohanta, R. Mohayai, T. A. Mokhov, N. Molina, J. Bueno, L. Molina Montanari, A. Montanari, C. Montanari, D. Zetina, L. M. Montano Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. Mousseau, J. Mu, W. and Mualem, L. Mueller, J. Muether, M. Mufson, S. Muheim, F. and Muir, A. Mulhearn, M. Muramatsu, H. Murphy, S. and Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. and Nandakumar, R. Naples, D. Narita, S. Navas-Nicolas, D. and Nayak, N. Nebot-Guinot, M. Necib, L. Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. Newbold, D. Newcomer, M. and Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J. A. and Oberling, M. Del Campo, A. Olivares Olivier, A. Onel, Y. and Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. and Papanestis, A. Paramesvaran, S. Park, J. C. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. J. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S. J. M. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. G. Perry, J. Pershey, D. and Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillow, J. Pinzino, J. and Plunkett, R. Poling, R. Pons, X. Poonthottathil, N. and Pordes, S. Potekhin, M. Potenza, R. Potukuchi, B. V. K. S. and Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. and Prince, S. Prior, G. Pugnere, D. Qi, K. Qian, X. and Raaf, J. L. Raboanary, R. Radeka, V. Rademacker, J. and Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. Rakotondramanana, H. T. Rakotondravohitra, L. and Ramachers, Y. A. Rameika, R. Delgado, M. A. Ramirez and Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Ravat, S. and Razafinime, H. Real, J. S. Rebel, B. Redondo, D. and Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. Resnati, F. Reynolds, A. and Riccobene, G. Rice, L. C. J. Rielage, K. Rigaut, Y. and Rivera, D. Rochester, L. Roda, M. Rodrigues, P. Alonso, M. J. Rodriguez Rondon, J. Rodriguez Roeth, A. J. Rogers, H. and Rosauro-Alcaraz, S. Rossella, M. Rout, J. Roy, S. and Rubbia, A. Rubbia, C. Russell, B. Russell, J. and Ruterbories, D. Saakyan, R. Sacerdoti, S. Safford, T. and Sahu, N. Sala, P. Samios, N. Sanchez, M. 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Vaziri, K. and Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. and Verzocchi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. and Viren, B. Vrba, T. Wachala, T. Waldron, A. V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. and Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. and Wenman, D. Wetstein, M. While, M. R. White, A. and Whitehead, L. H. Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. and Wongjirad, T. Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. and Yang, T. Yershov, N. Yonehara, K. Young, T. Yu, B. and Yu, J. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. and Zani, A. Zazueta, L. Zeller, G. P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhao, Y. Zhivun, E. Zhu, G. and Zimmerman, E. D. Zito, M. Zucchelli, S. Zuklin, J. and Zutshi, V. Zwaska, R.

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE's sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach.

Published
2021

11. Integration of second-life battery packs for self-consumption applications: analysis of a real experience

Author

Pablo Zorrilla, Ignacio R. Matias, Adrian Soto, Wenceslao Eduardo Rodríguez, Alberto Berrueta, Pablo Sanchis, Adolfo Josué Rodríguez Rodríguez, Alvaro Iribarren, Diego H. Castillo, Alfredo Ursua, David T. Vargas, Universidad Pública de Navarra. Departamento de Ingeniería Eléctrica, Electrónica y de Comunicación, Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa. ISC - Institute of Smart Cities, Nafarroako Unibertsitate Publikoa. Ingeniaritza Elektriko, Elektroniko eta Telekomunikazio Saila, Gobierno de Navarra / Nafarroako Gobernua, 0011–1411–2018–000029 GERA, and Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, ReBMS PJUPNA1904

Subjects
Battery (electricity), Lithium-ion, business.product_category, Second-life, Maximum power principle, Computer science, Energy management, Energy storage system, Battery, Grid, Battery pack, Reliability engineering, Technical feasibility, State of charge, Electric vehicle, SOC, business
Abstract

This contribution presents a methodology for the integration of Li-ion batteries discarded from electric vehicle into a collective self-consumption installation, showing the technical feasibility of such battery second use. In this regard, the state of charge (SOC) estimation is a relevant issue for the energy management of the second-life battery. Therefore, a SOC estimator is proposed in this contribution and tested in field. Moreover, the revealed costs analysis allows an economic comparison between the integration of a discarded battery pack in a second-life application or a remanufacture of these packs, thereby selecting the most suitable cells to build second-life batteries. This is a crucial issue for companies focused on the development of second-life batteries. The results obtained after testing the second-life battery pack in a real installation make it possible to extol the benefits of including this type of batteries in a self-consumption system, reaching a self-consumption ratio of 69 % and reducing by 36 % the maximum power peak demanded from the grid. This work has been supported by the Spanish State Research Agency (AEI) under grants PID2019-111262RB-I00 /AEI/ 10.13039/501100011033 and DPI2016–80641-R, the European Union under the H2020 project STARDUST (774094), the Government of Navarra through research project 0011–1411–2018–000029 GERA and the Public University of Navarra under project ReBMS PJUPNA1904. Also noteworthy is the support received from the Mexican Program for Strengthening Educational Quality (PFCE) (2017-2021) for the Postgraduate Program Master of Science and -UAT.

Published
2021

12. Supernova neutrino burst detection with the deep underground neutrino experiment: DUNE Collaboration

Author

Abi, B. Acciarri, R. Acero, M.A. Adamov, G. Adams, D. Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Alonso Monsalve, S. Alt, C. Anderson, J. Andreopoulos, C. Andrews, M.P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L.O. Arroyave, M.A. Asaadi, J. Aurisano, A. Aushev, V. Autiero, D. Azfar, F. Back, H. Back, J.J. Backhouse, C. Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G.J. Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. Barros, N. Barrow, J.L. Bashyal, A. Basque, V. Bay, F. Alba, J.L.B. Beacom, J.F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. Beltramello, O. Belver, D. Benekos, N. Bento Neves, F. Berger, J. Berkman, S. Bernardini, P. Berner, R.M. Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blanco Siffert, B. Blaszczyk, F.D.M. Blazey, G.C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S.B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S.J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. Carini, G. Carlus, B. Carniti, P. Caro Terrazas, I. Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. Choubey, S. Christensen, A. Christian, D. Christodoulou, G. Church, E. Clarke, P. Coan, T.E. Cocco, A.G. Coelho, J.A.B. Conley, E. Conrad, J.M. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadón, J.I. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. Cussans, D. Dabrowski, M. da Motta, H. Da Silva Peres, L. David, C. David, Q. Davies, G.S. Davini, S. Dawson, J. De, K. De Almeida, R.M. Debbins, P. De Bonis, I. Decowski, M.P. de Gouvêa, A. De Holanda, P.C. De Icaza Astiz, I.L. Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. Dell-Acqua, A. De Lurgio, P. de Mello Neto, J.R.T. DeMuth, D.M. Dennis, S. Densham, C. Deptuch, G. De Roeck, A. De Romeri, V. De Vries, J.J. Dharmapalan, R. Dias, M. Diaz, F. Díaz, J.S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M.J. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D.A. Dyshkant, A.S. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C.O. Escudero Sanchez, L. Evans, J.J. Ewart, E. Ezeribe, A.C. Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. Filthaut, F. Fitzpatrick, R.S. Flanagan, W. Fleming, B. Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A.P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. Gao, S. Garcia-Gamez, D. García-Peris, M.Á. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Girerd, C. Giri, A.K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R.A. Gomez Bermeo, L.V. Gomez Fajardo, L.S. Gonnella, F. Gonzalez-Cuevas, J.A. Goodman, M.C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. Green, P. Green, S. Greenler, L. 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Pasternak, J. Pater, J. Patrick, C. Patrizii, L. Patterson, R.B. Patton, S.J. Patzak, T. Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S.J.M. Penichot, Y. Pennacchio, E. Penzo, A. Peres, O.L.G. Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. Pillow, J. Pinzino, J. Plunkett, R. Poling, R. Pons, X. Poonthottathil, N. Pordes, S. Potekhin, M. Potenza, R. Potukuchi, B.V.K.S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. Pugnere, D. Qi, K. Qian, X. Raaf, J.L. Raboanary, R. Radeka, V. Rademacker, J. Radics, B. Rafique, A. Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. Rakotondramanana, H.T. Rakotondravohitra, L. Ramachers, Y.A. Rameika, R. Ramirez Delgado, M.A. Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J.S. Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. Reichenbacher, J. Reitzner, S.D. Renshaw, A. Rescia, S. Resnati, F. Reynolds, A. Riccobene, G. Rice, L.C.J. Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. Rodrigues, P. Rodriguez Alonso, M.J. Rodriguez Rondon, J. Roeth, A.J. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M.C. Sanders, D.A. Sankey, D. Santana, S. Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. Sensenig, J. Seong, I. Sergi, A. Sergiampietri, F. Sgalaberna, D. Shaevitz, M.H. Shafaq, S. Shamma, M. Sharma, H.R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F.W. Sirri, G. Sitraka, A. Siyeon, K. Smargianaki, D. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. Snopok, P. Soares Nunes, M. Sobel, H. Soderberg, M. Solano Salinas, C.J. Söldner-Rembold, S. Solomey, N. Solovov, V. Sondheim, W.E. Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. Spitz, J. Spooner, N.J.C. Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H.M. Stewart, J. Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C.M. Svoboda, R. Szczerbinska, B. Szelc, A.M. Talaga, R. Tanaka, H.A. Tapia Oregui, B. Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A.M. Tenti, M. Terao, K. Ternes, C.A. Terranova, F. Testera, G. Thea, A. Thompson, J.L. Thorn, C. Timm, S.C. Tonazzo, A. Torti, M. Tórtola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. Trevor, J. Trzaska, W.H. Tsai, Y.T. Tsamalaidze, Z. Tsang, K.V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. Tzanov, M. Uchida, M.A. Urheim, J. Usher, T. Vagins, M.R. Vahle, P. Valdiviesso, G.A. Valencia, E. Vallari, Z. Valle, J.W.F. Vallecorsa, S. Van Berg, R. Van de Water, R.G. Vanegas Forero, D. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M.A. Verzocchi, M. Vieira de Souza, H. Vignoli, C. Vilela, C. Viren, B. Vrba, T. Wachala, T. Waldron, A.V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M.R. White, A. Whitehead, L.H. Whittington, D. Wilking, M.J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R.J. Wolcott, J. Wongjirad, T. Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G.P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E.D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. Zwaska, R.

Subjects
Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Physics::Geophysics
Abstract

The deep underground neutrino experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the νe spectral parameters of the neutrino burst will be considered. © 2021, The Author(s).

Published
2021

13. Volume IV The DUNE far detector single-phase technology

Author

Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, N. Barrow, J. L. Bashyal, A. Basque, V Bay, F. Bazo Alba, J. Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V Beltramello, O. Belver, D. Benekos, N. Neves, F. Bento Berger, J. and Berkman, S. Bernardini, P. Berner, R. M. Berns, H. and Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. and Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. and Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. Blucher, E. and Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. and Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. and Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. and Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. and Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. and Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. and Caratelli, D. Carini, G. Carlus, B. Carniti, P. and Terrazas, I. Caro Carranza, H. Castillo, A. Castromonte, C. and Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. and Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. and Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. and Choubey, S. Christensen, A. Christian, D. Christodoulou, G. and Church, E. Clarke, P. Coan, T. E. Cocco, A. G. and Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. and Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadon, I, J. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. and Cussans, D. Dabrowski, M. Da Motta, H. Peres, L. Da Silva and David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. and De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. and De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza and Deisting, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. and Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. and Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. and Ereditato, A. Escobar, C. Sanchez, L. Escudero Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Gomez Bermeo, L. and Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. and Heeger, K. M. Hennessy, K. Henry, S. Hernandez Morquecho, M. and Herner, K. Hertel, L. Hesam, A. S. Hewes, J. and Pichardo, A. Higuera Hill, T. Hillier, S. J. Himmel, A. and Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. Howell, R. and Huang, J. Huang, J. Hugon, J. Iles, G. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I and Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. Khabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V Kothekar, K. Krennrich, F. Kreslo, I Kudenko, Y. and Kudryavtsev, V Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V Kutter, T. Lambert, A. Lande, K. Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. Leigui Leitner, M. Leyton, M. and Li, L. Li, S. Li, S. Li, T. Li, Y. Liao, H. and Lin, C. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. Louis, W. C. and Luk, K. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. and MacFarland, D. Machado, A. Machado, P. Macias, C. and Macier, J. Maddalena, A. Madigan, P. Magill, S. Mahn, K. and Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. C. and Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marinho, F. Marino, A. D. and Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Albo, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Mastbaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. and Menary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, M. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V Papadimitriou, V and Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillow, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, V, B. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I and Rakotondramanana, H. Rakotondravohitra, L. Ramachers, Y. and Rameika, R. Ramirez Delgado, M. Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I and Savage, G. Savinov, V Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Solano Salinas, C. J. and Soldner-Rembold, S. Solomey, N. Solovov, V Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, W. H. Tsai, Y. T. Tsamalaidze, Z. and Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, M. Uchida, M. A. Urheim, J. Usher, T. and Vagins, M. Vahle, P. Valdiviesso, G. Valencia, E. and Vallari, Z. Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Forero, D. Vanegas Varanini, F. Vargas, D. and Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, V, A. Wallbank, M. and Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zucchelli, S. Zuklin, J. Zutshi, V Zwaska, R. DUNE Collaboration

Published
2020

14. Volume I. Introduction to DUNE

Author

Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V. and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bayby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenhoim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Monarca, J. Barranco and Barros, N. Barrow, J. L. Bashyal, A. Basque, V. Bay, F. Alba, J. Bazo Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. and Beltramello, O. Belver, D. Benckos, N. Neves, F. Bento and Berger, J. Berkman, S. Bernardini, P. Berner, R. M. and Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. and Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. and Biassoni, M. Bierv, K. Bilki, B. Bishai, M. Bitadze, A. and Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. and Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. and Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. and Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. Bovden, D. Bracinik, J. Braga, D. and Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. Brizzolari, C. Bromherg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. and Budd, H. Caiulo, D. Calaftura, P. Calcutt, J. Calin, M. and Calvez, S. Calvo, E. Camilleri, L. Caminata, A. and Campanelli, M. Caratelli, D. Carini, G. Carlus, B. and Carniti, P. Terrazas, I. Caro Carranza, H. Castillo, A. and Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. and Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. and Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. and Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. and Cho, K. Choubey, S. Christensen, A. Christian, D. and Christodoulou, G. Church, E. Clarke, P. Coan, T. E. and Cocco, A. G. Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. and Crespo-Anadon, J. I. Cristaldo, E. Cross, R. Cuesta, C. and Cui, Y. Cussans, D. Dahrowski, M. Da Motta, H. Da Silva Peres, L. David, Q. Davies, G. S. Davini, S. Dawson, J. and De, K. De Almeida, R. M. Debbins, P. De Bonis, I. and Decowski, M. De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza Deistin, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V. De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. and Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. and Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C. Escudero Sanchez, L. Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Menendez, P. Fernandez Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I. Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, L. Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Bermeo, L. Gomez and Fajardo, L. S. Gomez Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. Goodwin, O. Goswami, S. Gotti, C. and Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. and Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. and Griffith, C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. and Guthikonda, K. Gutierrez, R. Guzowski, P. Guzzo, M. M. and Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. and Hamilton, P. Han, J. Harder, K. Harris, D. A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. and Heeger, K. M. Hennessy, K. Henry, S. Morquecho, Vi. Hernandez Herner, K. Hertel, L. Hesam, A. S. Hewes, J. and Pichardo, A. Higuera Hill, T. Hillier, S. J. Himmel, A. and Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. Howell, R. and Huang, J. Huang, J. Hugon, J. Iles, G. Iliescu, A. M. and Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. and James, E. Jargowsky, B. Jediny, F. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. Jipa, A. Joglekar, A. and Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C. and Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. and Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. and Karyotakis, Y. Kasai, S. Kasetti, S. P. Kashur, L. and Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. and Ketchum, W. Kettell, S. Kliabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kordosky, M. Kosc, T. Kose, U. Kostelecky, V. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. and Kudryavtsev, V. Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. Kutter, T. Lamhert, A. Lande, K. Lane, C. E. Lang, K. Langford, T. Lasorak, P. Last, D. and Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G. Lehmann and Lehnert, R. de Oliveira, M. Leigui Leitner, M. Leyton, M. and Li, L. Li, S. Li, S. Li, T. Li, Y. Liao, H. and Lin, C. Lin, S. Lister, A. Littlejohn, B. R. Liu, J. and Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. and Loo, K. Lorca, D. Lord, T. LoSecco, J. Louis, W. C. and Luk, K. Luo, X. Lurkin, N. Lux, T. Luzio, V. P. and MacFarland, D. Machado, A. Machado, P. Macias, C. and Macier, J. Maddalena, A. Madigan, P. Magill, S. Mahn, K. and Maio, A. Maloney, J. A. Mandrioli, G. Maneira, J. C. and Manenti, L. Manly, S. Mann, A. Manolopoulos, K. Plata, M. Manrique Marchionni, A. Marciano, W. Marfatia, D. and Mariani, C. Maricic, J. Marinho, F. Marino, A. D. and Marshak, M. Marshall, C. Marshall, J. Marteau, J. and Martin-Alho, J. Martinez, N. Caicedo, D. A. Martinez and Martynenko, S. Mason, K. Masthaum, A. Masud, M. Matsuno, S. Matthews, J. Mauger, C. Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. McNab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, V. Mena, O. and Mcnary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, V. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V. Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. and Pessina, G. Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillows, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, B. V. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V. Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajarialisoa, M. Rakhno, I. and Rakotondramanana, H. Rakotondravollitra, L. Ramachers, Y. and Rameika, R. Delgado, Vi. Ramirez Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I. and Savage, G. Savinov, V. Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I. Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Salinas, C. J. Solano and Soldner-Remhold, S. Solomey, N. Solovov, V. Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Strianov, S. Stuart, A. Summers, D. Surdo, A. Susic, V. Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, Wh. Tsai, Yt. Tsamalaidze, Z. Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, Vi. Uchida, Vi. A. Urheim, J. Usher, T. Vagins, Vi. Vahle, P. Valdiviesso, G. Valencia, E. Vallari, Z. and Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Vanegas Forero, D. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. and Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. and Vieira de Souza, H. Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, A. V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. and Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. and Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. and Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. and Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zuccilelli, S. Zuklin, J. Zuishi, V. Zwaska, R. DUNE Collaboration

Published
2020

15. Long-baseline neutrino oscillation physics potential of the DUNE experiment: DUNE Collaboration

Author

Abi, B. Acciarri, R. Acero, M.A. Adamov, G. Adams, D. Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S.A. Alt, C. Anderson, J. Andreopoulos, C. Andrews, M.P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L.O. Arroyave, M.A. Asaadi, J. Aurisano, A. Aushev, V. Autiero, D. Azfar, F. Back, H. Back, J.J. Backhouse, C. Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G.J. Barkhouse, W. Barnes, C. Barr, G. Monarca, J.B. Barros, N. Barrow, J.L. Bashyal, A. Basque, V. Bay, F. Alba, J.L.B. Beacom, J.F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V. Beltramello, O. Belver, D. Benekos, N. Neves, F.B. Berger, J. Berkman, S. Bernardini, P. Berner, R.M. Berns, H. Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B.B. Blaszczyk, F.D.M. Blazey, G.C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S.B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S.J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. Carini, G. Carlus, B. Carniti, P. Terrazas, I.C. Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Villanueva, A.C. Chalifour, M. Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. Choubey, S. Christensen, A. Christian, D. Christodoulou, G. Church, E. Clarke, P. Coan, T.E. Cocco, A.G. Coelho, J.A.B. Conley, E. Conrad, J.M. Convery, M. Corwin, L. Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadón, J.I. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. Cussans, D. Dabrowski, M. Motta, H. Da Silva Peres, L. David, C. David, Q. Davies, G.S. Davini, S. Dawson, J. De, K. De Almeida, R.M. Debbins, P. De Bonis, I. Decowski, M.P. de Gouvêa, A. De Holanda, P.C. De Icaza Astiz, I.L. Deisting, A. De Jong, P. Delbart, A. Delepine, D. Delgado, M. Dell’Acqua, A. De Lurgio, P. de Mello Neto, J.R.T. DeMuth, D.M. Dennis, S. Densham, C. Deptuch, G. De Roeck, A. De Romeri, V. De Vries, J.J. Dharmapalan, R. Dias, M. Diaz, F. Díaz, J.S. Domizio, S.D. Giulio, L.D. Ding, P. Noto, L.D. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M.J. Domine, L. Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D.A. Dyshkant, A.S. Eads, M. Edmunds, D. Eisch, J. Emery, S. Ereditato, A. Escobar, C.O. Sanchez, L.E. Evans, J.J. Ewart, E. Ezeribe, A.C. Fahey, K. Falcone, A. Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. Menendez, P.F. Ferraro, F. Fields, L. Filkins, A. Filthaut, F. Fitzpatrick, R.S. Flanagan, W. Fleming, B. Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. Freestone, J. Fried, J. Friedland, A. Fuess, S. Furic, I. Furmanski, A.P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V. Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. Gao, S. Garcia-Gamez, D. García-Peris, M.Á. Gardiner, S. Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I. Girerd, C. Giri, A.K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. Gollwitzer, K. Gomes, R.A. Bermeo, L.V.G. Fajardo, L.S.G. Gonnella, F. Gonzalez-Cuevas, J.A. Goodman, M.C. Goodwin, O. Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gramellini, E. Gran, R. Granados, E. Grant, A. Grant, C. Gratieri, D. Green, P. Green, S. Greenler, L. Greenwood, M. Greer, J. Griffith, W.C. Groh, M. Grudzinski, J. Grzelak, K. Gu, W. Guarino, V. Guenette, R. Guglielmi, A. Guo, B. Guthikonda, K.K. Gutierrez, R. Guzowski, P. Guzzo, M.M. Gwon, S. Habig, A. Hackenburg, A. Hadavand, H. Haenni, R. Hahn, A. Haigh, J. Haiston, J. Hamernik, T. Hamilton, P. Han, J. Harder, K. Harris, D.A. Hartnell, J. Hasegawa, T. Hatcher, R. Hazen, E. Heavey, A. Heeger, K.M. Heise, J. Hennessy, K. Henry, S. Morquecho, M.A.H. Herner, K. Hertel, L. Hesam, A.S. Hewes, J. Higuera, A. Hill, T. Hillier, S.J. Himmel, A. Hoff, J. Hohl, C. Holin, A. Hoppe, E. Horton-Smith, G.A. Hostert, M. Hourlier, A. Howard, B. Howell, R. Huang, J. Huang, J. Hugon, J. Iles, G. Ilic, N. Iliescu, A.M. Illingworth, R. Ioannisian, A. Itay, R. Izmaylov, A. James, E. Jargowsky, B. Jediny, F. Jesùs-Valls, C. Ji, X. Jiang, L. Jiménez, S. Jipa, A. Joglekar, A. Johnson, C. Johnson, R. Jones, B. Jones, S. Jung, C.K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I. Kamiya, F. Karagiorgi, G. Karcher, A. Karolak, M. Karyotakis, Y. Kasai, S. Kasetti, S.P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K.J. Kemp, E. Ketchum, W. Kettell, S.H. Khabibullin, M. Khotjantsev, A. Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. Klein, J. Koehler, K. Koerner, L.W. Kohn, S. Koller, P.P. Kordosky, M. Kosc, T. Kose, U. Kostelecký, V.A. Kothekar, K. Krennrich, F. Kreslo, I. Kudenko, Y. Kudryavtsev, V.A. Kulagin, S. Kumar, J. Kumar, R. Kuruppu, C. Kus, V. Kutter, T. Lambert, A. Lande, K. Lane, C.E. Lang, K. Langford, T. Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Lawrence, A. Lazanu, I. LaZur, R. Le, T. Learned, J. LeBrun, P. Miotto, G.L. Lehnert, R. de Oliveira, M.A.L. Leitner, M. Leyton, M. Li, L. Li, S. Li, S.W. Li, T. Li, Y. Liao, H. Lin, C.S. Lin, S. Lister, A. Littlejohn, B.R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. Lomidze, I. Long, K. Loo, K. Lorca, D. Lord, T. LoSecco, J.M. Louis, W.C. Luk, K.B. Luo, X. Lurkin, N. Lux, T. Luzio, V.P. MacFarland, D. Machado, A.A. Machado, P. Macias, C.T. Macier, J.R. 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Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

The sensitivity of the Deep Underground Neutrino Experiment (DUNE) to neutrino oscillation is determined, based on a full simulation, reconstruction, and event selection of the far detector and a full simulation and parameterized analysis of the near detector. Detailed uncertainties due to the flux prediction, neutrino interaction model, and detector effects are included. DUNE will resolve the neutrino mass ordering to a precision of 5σ, for all δCP values, after 2 years of running with the nominal detector design and beam configuration. It has the potential to observe charge-parity violation in the neutrino sector to a precision of 3σ (5σ) after an exposure of 5 (10) years, for 50% of all δCP values. It will also make precise measurements of other parameters governing long-baseline neutrino oscillation, and after an exposure of 15 years will achieve a similar sensitivity to sin 22 θ13 to current reactor experiments. © 2020, The Author(s).

Published
2020

16. Neutrino interaction classification with a convolutional neural network in the DUNE far detector

Author

Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. P. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V. and Autiero, D. Azfar, F. Back, H. Back, J. J. and Backhouse, C. Baesso, P. Bagby, L. Bajou, R. and Balasubramanian, S. Baldi, P. Bambah, B. Barao, F. and Barenboim, G. Barker, G. J. Barkhouse, W. Barnes, C. and Barr, G. Monarca, J. Barranco Barros, N. Barrow, J. L. and Bashyal, A. Basque, V. Bay, F. Alba, J. L. Bazo Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. and Bellettini, G. Bellini, V. Beltramello, O. Belver, D. and Benekos, N. Bento Neves, F. Berger, J. Berkman, S. and Bernardini, P. Berner, R. M. Berns, H. Bertolucci, S. and Betancourt, M. Bezawada, Y. Bhattacharjee, M. Bhuyan, B. and Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. and Bishai, M. Bitadze, A. Blake, A. Blanco Siffert, B. and Blaszczyk, F. D. M. Blazey, G. C. Blucher, E. Boissevain, J. and Bolognesi, S. Bolton, T. Bonesini, M. Bongrand, M. and Bonini, F. Booth, A. Booth, C. Bordoni, S. Borkum, A. and Boschi, T. Bostan, N. Bour, P. Boyd, S. B. Boyden, D. Bracinik, J. Braga, D. Brailsford, D. Brandt, A. and Bremer, J. Brew, C. Brianne, E. Brice, S. J. Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. Bross, A. and Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. Calvo, E. and Camilleri, L. Caminata, A. Campanelli, M. Caratelli, D. and Carini, G. Carlus, B. Carniti, P. Terrazas, I. Caro and Carranza, H. Castillo, A. Castromonte, C. Cattadori, C. and Cavalier, F. Cavanna, F. Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. Chang, C. and Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. and Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. and Childress, S. 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Mauri, N. Mavrokoridis, K. and Mazza, R. Mazzacane, A. Mazzucato, E. McCluskey, E. and McConkey, N. McFarland, K. S. McGrew, C. Mcnab, A. and Mefodiev, A. Mehta, P. Melas, P. Mellinato, M. Mena, O. and Menary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, M. D. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. and Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. S. Mishra, S. R. Mislivec, A. and Mladenov, D. Mocioiu, I. Moffat, K. Moggi, N. Mohanta, R. Mohayai, T. A. Mokhov, N. Molina, J. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. and Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. Mousseau, J. Mu, W. Mualem, L. Mueller, J. and Muether, M. Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. and Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. and Narita, S. Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. and Necib, L. Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. and Niner, E. Nishimura, K. Norman, A. Norrick, A. Northrop, R. Novella, P. Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. Onel, Y. Onishchuk, Y. Ott, J. and Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V. Papadimitriou, V. Papaleo, R. Papanestis, A. and Paramesvaran, S. Parke, S. Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. Pasternak, J. Pater, J. Patrick, C. and Patrizii, L. Patterson, R. B. Patton, S. J. Patzak, T. and Paudel, A. Paulos, B. Paulucci, L. Pavlovic, Z. and Pawloski, G. Payne, D. Pec, V. Peeters, S. J. M. and Penichot, Y. Pennacchio, E. Penzo, A. Peres, O. L. G. and Perry, J. Pershey, D. Pessina, G. Petrillo, G. Petta, C. and Petti, R. Piastra, F. Pickering, L. Pietropaolo, F. and Pillow, J. Pinzino, J. Plunkett, R. Poling, R. Pons, X. and Poonthottathil, N. Pordes, S. Potekhin, M. Potenza, R. and Potukuchi, B. V. K. S. Pozimski, J. Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. Pugnere, D. Qi, K. Qian, X. Raaf, J. L. Raboanary, R. Radeka, V. and Rademacker, J. Radics, B. Radovic, A. Rafique, A. and Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I. and Rakotondramanana, H. T. Rakotondravohitra, L. Ramachers, Y. A. and Rameika, R. Delgado, M. A. Ramirez Ramson, B. Rappoldi, A. Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. and Real, J. S. Rebel, B. Redondo, D. Reggiani-Guzzo, M. and Rehak, T. Reichenbacher, J. Reitzner, S. D. Renshaw, A. and Rescia, S. Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. J. Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. and Roda, M. Rodrigues, P. Alonso, M. J. Rodriguez Rondon, J. Rodriguez Roeth, A. J. Rogers, H. Rosauro-Alcaraz, S. and Rossella, M. Rout, J. Roy, S. Rubbia, A. Rubbia, C. and Russell, B. Russell, J. Ruterbories, D. Saakyan, R. and Sacerdoti, S. Safford, T. Sahu, N. Sala, P. Samios, N. and Sanchez, M. C. Sanders, D. A. Sankey, D. Santana, S. and Santos-Maldonado, M. Saoulidou, N. Sapienza, P. Sarasty, C. and Sarcevic, I. Savage, G. Savinov, V. Scaramelli, A. and Scarff, A. Scarpelli, A. Schaffer, T. Schellman, H. and Schlabach, P. Schmitz, D. Scholberg, K. Schukraft, A. and Segreto, E. Sensenig, J. Seong, I. Sergi, A. and Sergiampietri, F. Sgalaberna, D. Shaevitz, M. H. Shafaq, S. and Shamma, M. Sharma, H. R. Sharma, R. Shaw, T. and Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. and Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V. Sipos, R. Sippach, F. W. and Sirri, G. Sitraka, A. Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. Smith, P. Smolik, J. Smy, M. and Snopok, P. Soares Nunes, M. Sobel, H. Soderberg, M. and Salinas, C. J. Solano Soldner-Rembold, S. Solomey, N. and Solovov, V. Sondheim, W. E. Sorel, M. Soto-Oton, J. and Sousa, A. Soustruznik, K. Spagliardi, F. Spanu, M. and Spitz, J. Spooner, N. J. C. Spurgeon, K. Staley, R. and Stancari, M. Stanco, L. Steiner, H. M. Stewart, J. and Stillwell, B. Stock, J. Stocker, F. Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. and Surdo, A. Susic, V. Suter, L. Sutera, C. M. Svoboda, R. and Szczerbinska, B. Szelc, A. M. Talaga, R. Tanaka, H. A. and Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. and Tayloe, R. Teklu, A. M. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. C. Tonazzo, A. Torti, M. Tortola, M. Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, W. H. Tsai, Y. T. Tsamalaidze, Z. and Tsang, K. V. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, M. Uchida, M. A. Urheim, J. Usher, T. and Vagins, M. R. Vahle, P. Valdiviesso, G. A. Valencia, E. and Vallari, Z. Valle, J. W. F. Vallecorsa, S. Van Berg, R. and Van de Water, R. G. Vanegas Forero, D. Varanini, F. Vargas, D. Varner, G. Vasel, J. Vasseur, G. Vaziri, K. and Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. and Verzocchi, M. Vieira de Souza, H. Vignoli, C. Vilela, C. and Viren, B. Vrba, T. Wachala, T. Waldron, A. V. Wallbank, M. Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. and Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. and Wenman, D. Wetstein, M. While, M. R. White, A. and Whitehead, L. H. Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. and Wongjirad, T. Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. and Yang, T. Yershov, N. Yonehara, K. Young, T. Yu, B. and Yu, J. Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. and Zani, A. Zazueta, L. Zeller, G. P. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. Zucchelli, S. Zuklin, J. Zutshi, V. and Zwaska, R. DUNE Collaboration

Subjects
Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

The Deep Underground Neutrino Experiment is a next-generation neutrino oscillation experiment that aims to measure CP-violation in the neutrino sector as part of a wider physics program. A deep learning approach based on a convolutional neural network has been developed to provide highly efficient and pure selections of electron neutrino and muon neutrino charged-current interactions. The electron neutrino (antineutrino) selection efficiency peaks at 90% (94%) and exceeds 85% (90%) for reconstructed neutrino energies between 2-5 GeV. The muon neutrino (antineutrino) event selection is found to have a maximum efficiency of 96% (97%) and exceeds 90% (95%) efficiency for reconstructed neutrino energies above 2 GeV. When considering all electron neutrino and antineutrino interactions as signal, a selection purity of 90% is achieved. These event selections are critical to maximize the sensitivity of the experiment to CP-violating effects.

Published
2020

17. Volume III DUNE far detector technical coordination

Author

Abi, B. Acciarri, R. Acero, M. A. Adamov, G. Adams, D. and Adinolfi, M. Ahmad, Z. Ahmed, J. Alion, T. Monsalve, S. Alonso Alt, C. Anderson, J. Andreopoulos, C. Andrews, M. Andrianala, F. Andringa, S. Ankowski, A. Antonova, M. and Antusch, S. Aranda-Fernandez, A. Ariga, A. Arnold, L. O. and Arroyave, M. A. Asaadi, J. Aurisano, A. Aushev, V and Autiero, D. Azfar, F. Back, H. Back, J. J. Backhouse, C. and Baesso, P. Bagby, L. Bajou, R. Balasubramanian, S. and Baldi, P. Bambah, B. Barao, F. Barenboim, G. Barker, G. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, N. Barrow, J. L. Bashyal, A. Basque, V Bay, F. Bazo Alba, J. Beacom, J. F. Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. Bellini, V Beltramello, O. Belver, D. Benekos, N. Neves, F. Bento Berger, J. and Berkman, S. Bernardini, P. Berner, R. M. Berns, H. and Bertolucci, S. Betancourt, M. Bezawada, Y. Bhattacharjee, M. and Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. and Bilki, B. Bishai, M. Bitadze, A. Blake, A. Siffert, B. Blanco Blaszczyk, F. Blazey, G. Blucher, E. and Boissevain, J. Bolognesi, S. Bolton, T. Bonesini, M. and Bongrand, M. Bonini, F. Booth, A. Booth, C. Bordoni, S. and Borkum, A. Boschi, T. Bostan, N. Bour, P. Boyd, S. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Brandt, A. Bremer, J. Brew, C. Brianne, E. Brice, S. J. and Brizzolari, C. Bromberg, C. Brooijmans, G. Brooke, J. and Bross, A. Brunetti, G. Buchanan, N. Budd, H. Caiulo, D. Calafiura, P. Calcutt, J. Calin, M. Calvez, S. and Calvo, E. Camilleri, L. Caminata, A. Campanelli, M. and Caratelli, D. Carini, G. Carlus, B. Carniti, P. and Terrazas, I. Caro Carranza, H. Castillo, A. Castromonte, C. and Cattadori, C. Cavalier, F. Cavanna, F. Centro, S. and Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. and Chang, C. Chardonnet, E. Chatterjee, A. Chattopadhyay, S. Chaves, J. Chen, H. Chen, M. Chen, Y. Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. Cho, K. and Choubey, S. Christensen, A. Christian, D. Christodoulou, G. and Church, E. Clarke, P. Coan, T. E. Cocco, A. G. and Coelho, J. Conley, E. Conrad, J. Convery, M. Corwin, L. and Cotte, P. Cremaldi, L. Cremonesi, L. Crespo-Anadon, I, J. Cristaldo, E. Cross, R. Cuesta, C. Cui, Y. and Cussans, D. Dabrowski, M. Da Motta, H. Peres, L. Da Silva and David, Q. Davies, G. S. Davini, S. Dawson, J. De, K. and De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. and De Gouvea, A. De Holanda, P. C. Astiz, I. L. De Icaza and Deisting, A. De Jong, P. Delbart, A. Delepine, D. and Delgado, M. Dell'Acqua, A. De Lurgio, P. De Mello Neto, J. R. DeMuth, D. M. Dennis, S. Densham, C. Deptuch, G. and De Roeck, A. De Romeri, V De Vries, J. Dharmapalan, R. and Dias, M. Diaz, F. Diaz, J. Di Domizio, S. Di Giulio, L. and Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. Dokania, N. Dolinski, M. Domine, L. and Douglas, D. Drielsma, F. Duchesneau, D. Duffy, K. Dunne, P. Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. and Dyshkant, A. Eads, M. Edmunds, D. Eisch, J. Emery, S. and Ereditato, A. Escobar, C. Sanchez, L. Escudero Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. and Farnese, C. Farzan, Y. Felix, J. Fernandez-Martinez, E. and Fernandez Menendez, P. Ferraro, F. Fields, L. Filkins, A. and Filthaut, F. Fitzpatrick, R. S. Flanagan, W. Fleming, B. and Flight, R. Fowler, J. Fox, W. Franc, J. Francis, K. and Franco, D. Freeman, J. Freestone, J. Fried, J. and Friedland, A. Fuess, S. Furic, I Furmanski, A. P. Gago, A. Gallagher, H. Gallego-Ros, A. Gallice, N. Galymov, V and Gamberini, E. Gamble, T. Gandhi, R. Gandrajula, R. and Gao, S. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Ge, G. Gelli, B. Gendotti, A. Gent, S. and Ghorbani-Moghaddam, Z. Gibin, D. Gil-Botella, I Girerd, C. Giri, A. Gnani, D. Gogota, O. Gold, M. and Gollapinni, S. Gollwitzer, K. Gomes, R. A. Gomez Bermeo, L. and Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. and Goodman, M. C. 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Mena, O. and Menary, S. Mendez, H. Menegolli, A. Meng, G. and Messier, M. Metcalf, W. Mewes, M. Meyer, H. Miao, T. and Michna, G. Miedema, T. Migenda, J. Milincic, R. Miller, W. Mills, J. Milne, C. Mineev, O. Miranda, O. G. and Miryala, S. Mishra, C. Mishra, S. Mislivec, A. Mladenov, D. Mocioiu, I Moffat, K. Moggi, N. Mohanta, R. and Mohayai, T. A. Mokhov, N. Molina, J. A. Bueno, L. Molina and Montanari, A. Montanari, C. Montanari, D. Montano Zetina, L. M. Moon, J. Mooney, M. Moor, A. Moreno, D. Morgan, B. Morris, C. Mossey, C. Motuk, E. Moura, C. A. and Mousseau, J. Mu, W. Mualem, L. Mueller, J. Muether, M. and Mufson, S. Muheim, F. Muir, A. Mulhearn, M. and Muramatsu, H. Murphy, S. Musser, J. Nachtman, J. Nagu, S. Nalbandyan, M. Nandakumar, R. Naples, D. Narita, S. and Navas-Nicolas, D. Nayak, N. Nebot-Guinot, M. Necib, L. and Negishi, K. Nelson, J. K. Nesbit, J. Nessi, M. and Newbold, D. Newcomer, M. Newhart, D. Nichol, R. Niner, E. Nishimura, K. Norman, A. Northrop, R. Novella, P. and Nowak, J. A. Oberling, M. Del Campo, A. Olivares Olivier, A. and Onel, Y. Onishchuk, Y. Ott, J. Pagani, L. Pakvasa, S. Palamara, O. Palestini, S. Paley, J. M. Pallavicini, M. Palomares, C. Pantic, E. Paolone, V Papadimitriou, V and Papaleo, R. Papanestis, A. Paramesvaran, S. Parke, S. and Parsa, Z. Parvu, M. Pascoli, S. Pasqualini, L. and Pasternak, J. Pater, J. Patrick, C. Patrizii, L. and Patterson, R. B. Patton, S. Patzak, T. Paudel, A. and Paulos, B. Paulucci, L. Pavlovic, Z. Pawloski, G. Payne, D. Pec, V Peeters, S. J. Penichot, Y. Pennacchio, E. and Penzo, A. Peres, O. L. Perry, J. Pershey, D. Pessina, G. and Petrillo, G. Petta, C. Petti, R. Piastra, F. and Pickering, L. Pietropaolo, F. Pillow, J. Plunkett, R. and Poling, R. Pons, X. Poonthottathil, N. Pordes, S. and Potekhin, M. Potenza, R. Potukuchi, V, B. Pozimski, J. and Pozzato, M. Prakash, S. Prakash, T. Prince, S. Prior, G. and Pugnere, D. Qi, K. Qian, X. Raaf, J. Raboanary, R. and Radeka, V Rademacker, J. Radics, B. Rafique, A. and Raguzin, E. Rai, M. Rajaoalisoa, M. Rakhno, I and Rakotondramanana, H. Rakotondravohitra, L. Ramachers, Y. and Rameika, R. Delgado, M. Ramirez Ramson, B. Rappoldi, A. and Raselli, G. Ratoff, P. Ravat, S. Razafinime, H. Real, J. and Rebel, B. Redondo, D. Reggiani-Guzzo, M. Rehak, T. and Reichenbacher, J. Reitzner, S. D. Renshaw, A. Rescia, S. and Resnati, F. Reynolds, A. Riccobene, G. Rice, L. C. and Rielage, K. Rigaut, Y. Rivera, D. Rochester, L. Roda, M. and Rodrigues, P. Alonso, M. Rodriguez Rondon, J. Rodriguez and Roeth, A. Rogers, H. Rosauro-Alcaraz, S. Rossella, M. and Rout, J. Roy, S. Rubbia, A. Rubbia, C. Russell, B. and Russell, J. Ruterbories, D. Saakyan, R. Sacerdoti, S. and Safford, T. Sahu, N. Sala, P. Samios, N. Sanchez, M. and Sanders, D. A. Sankey, D. Santana, S. Santos-Maldonado, M. and Saoulidou, N. Sapienza, P. Sarasty, C. Sarcevic, I and Savage, G. Savinov, V Scaramelli, A. Scarff, A. and Scarpelli, A. Schaffer, T. Schellman, H. Schlabach, P. and Schmitz, D. Scholberg, K. Schukraft, A. Segreto, E. and Sensenig, J. Seong, I Sergi, A. Sergiampietri, F. and Sgalaberna, D. Shaevitz, M. Shafaq, S. Shamma, M. and Sharma, H. R. Sharma, R. Shaw, T. Shepherd-Themistocleous, C. Shin, S. Shooltz, D. Shrock, R. Simard, L. Simos, N. Sinclair, J. Sinev, G. Singh, J. Singh, J. Singh, V Sipos, R. Sippach, F. Sirri, G. Sitraka, A. and Siyeon, K. Smargianaki, D. Smith, A. Smith, A. Smith, E. and Smith, P. Smolik, J. Smy, M. Snopok, P. Nunes, M. Soares Sobel, H. Soderberg, M. Solano Salinas, C. J. and Soldner-Rembold, S. Solomey, N. Solovov, V Sondheim, W. E. and Sorel, M. Soto-Oton, J. Sousa, A. Soustruznik, K. and Spagliardi, F. Spanu, M. Spitz, J. Spooner, N. J. and Spurgeon, K. Staley, R. Stancari, M. Stanco, L. Steiner, H. Stewart, J. Stillwell, B. Stock, J. Stocker, F. and Stokes, T. Strait, M. Strauss, T. Striganov, S. Stuart, A. Summers, D. Surdo, A. Susic, V Suter, L. Sutera, C. Svoboda, R. Szczerbinska, B. Szelc, A. Talaga, R. and Tanaka, H. Oregui, B. Tapia Tapper, A. Tariq, S. Tatar, E. Tayloe, R. Teklu, A. Tenti, M. Terao, K. Ternes, C. A. Terranova, F. Testera, G. Thea, A. Thompson, J. L. and Thorn, C. Timm, S. Tonazzo, A. Torti, M. Tortola, M. and Tortorici, F. Totani, D. Toups, M. Touramanis, C. and Trevor, J. Trzaska, W. H. Tsai, Y. T. Tsamalaidze, Z. and Tsang, K. Tsverava, N. Tufanli, S. Tull, C. Tyley, E. and Tzanov, M. Uchida, M. A. Urheim, J. Usher, T. and Vagins, M. Vahle, P. Valdiviesso, G. Valencia, E. and Vallari, Z. Valle, J. W. Vallecorsa, S. Van Berg, R. Van de Water, R. G. Forero, D. Vanegas Varanini, F. Vargas, D. and Varner, G. Vasel, J. Vasseur, G. Vaziri, K. Ventura, S. Verdugo, A. Vergani, S. Vermeulen, M. A. Verzocchi, M. de Souza, H. Vieira Vignoli, C. Vilela, C. Viren, B. and Vrba, T. Wachala, T. Waldron, V, A. Wallbank, M. and Wang, H. Wang, J. Wang, Y. Wang, Y. Warburton, K. and Warner, D. Wascko, M. Waters, D. Watson, A. Weatherly, P. Weber, A. Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. While, M. R. White, A. Whitehead, L. H. and Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wolcott, J. Wongjirad, T. and Wood, K. Wood, L. Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. Xiao, Y. Yang, G. Yang, T. and Yershov, N. Yonehara, K. Young, T. Yu, B. Yu, J. and Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. Zazueta, L. Zeller, G. Zennamo, J. Zeug, K. Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zimmerman, E. D. Zito, M. and Zucchelli, S. Zuklin, J. Zutshi, V Zwaska, R. DUNE Collaboration

Published
2020

18. Fluorescent Conductive Protein-dye Microfibers Co-assembled in vivo

Author

G. Tommasini, M. Moros, F. Di Maria, P. Dardano, M. Zangoli, H. Castillo-Michel, M. Blasio, L. De Stefano, A. Tino, G. Barbarella, and C. Tortiglione

Subjects
in vivo, conductive fibers
Abstract

Fluorescent Conductive Protein-dye Microfibers Co-assembled in vivo

Published
2019

19. Investigation of the iron oxidation state in ovarian cancer using synchrotron micro X-ray absorption near edge structure - preliminary results

Author

D. M. Krauze, Dariusz Adamek, M. Grzelak, Pawel Wrobel, Giulia Veronesi, Robert Jach, H. Castillo, Marek Lankosz, L. Chmura, Faculty of Physics and Applied Computer Science [Kraków] (FPACS), AGH University of Science and Technology [Krakow, PL] (AGH UST), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), European Synchrotron Radiation Facility (ESRF), Department of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical College, Department of Gynecology and Obstetrics, Faculty of Medicine, Jagiellonian University Medical College, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ)

Subjects
0301 basic medicine, Absorption (pharmacology), Absorption spectroscopy, Chemistry, Inorganic chemistry, Trace element, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Chemical reaction, XANES, 3. Good health, Analytical Chemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Absorption edge, Transition metal, Oxidation state, 030220 oncology & carcinogenesis, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Spectroscopy
Abstract

International audience; Iron as a trace element plays a role in regulating the homeostasis of the human body and therefore the concentration of iron in the body must be carefully monitored. Both deficiency and overload of iron could have a serious effect on health. Iron in excess can be carcinogenic in different ways. As a catalyst of Fenton's reaction it leads to the creation of reactive oxygen species which causes oxidative stress and DNA damage, among other things. Iron can also reduce the response of the immune system to cancer and induce increased cancer cell proliferation. Ovarian cancer is one of the most common neoplasms in women and has a low survival rate. For this reason, there is strong motivation to deepen the understanding of the processes that lead to the disease and take place in ovarian cancer tissue. In this study, cryo micro X-ray absorption near edge structure spectroscopy was used to analyse the oxidation state of iron in ovarian cancer samples. For calibration, organic and inorganic reference samples containing Fe in different oxidation states were used. To determine the trace element in the neoplasm samples, the pre-edge region, white line and absorption edge position of Fe K-edge XANES spectra were examined and compared to those of the recorded reference materials. A comparison of these XANES spectral features shows the existence of differences in the iron oxidation state between the neoplasm samples and suggests the possibility that a combination of iron ions can occur in one sample. Overall, further investigations are required to make a better comparison and determine what organic compounds are contained in the samples and possibly carry out a statistical analysis.

Published
2018
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20. In vivo transformations of indium phosphide quantum dots in a model organism

Author

G Veronesi, M Moros, H Castillo-Michel, K. Wegner, L Mattera, P Reiss, and C Tortiglione

Subjects
Condensed Matter::Materials Science, Physics::Instrumentation and Detectors, Physics::Optics, Nuclear Experiment, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, InP Quantum dots
Abstract

In vivo transformations of indium phosphide quantum dots in a model organism

Published
2018

21. A deep insight into the intracellular fate of colloidal semiconductor nanocrystals in vivo

Author

G Veronesi, M Moros, H Castillo-Michel, K. D Wegner, L Mattera, P Reiss, and C Tortiglione

Subjects
education, digestive, oral, and skin physiology, technology, industry, and agriculture, equipment and supplies, complex mixtures, InP Quantum dots
Abstract

A deep insight into the intracellular fate of colloidal semiconductor nanocrystals in vivo

Published
2018

22. Affective Feedback in Intelligent Tutoring Systems : A Practical Approach

Author

Samantha Jiménez, Reyes Juárez-Ramírez, Victor H. Castillo, Juan José Tapia Armenta, Samantha Jiménez, Reyes Juárez-Ramírez, Victor H. Castillo, and Juan José Tapia Armenta

Subjects
Human-computer interaction, Intelligent tutoring systems, Affective education
Abstract

Affective components are as important as cognitive components in tutoring assisted learning process. Feedback from tutors is essential in keeping students motivated. Affectivity and motivation are also significant in computer-based tutoring systems. However, several educational frameworks do not include this kind of interaction between students and tutoring systems. In those cases, the students learning interest and motivation to learn could be negatively affected, and student profits from the system could be impoverished. This is why tutoring systems need to provide direct and affective interaction with students; it can encourage them and increase the motivation to learn. This book introduces a broad range of topics in affective learning in computer-based systems. The text offers a deep conceptual background, covering relevant concepts of affectivity, feedback and motivational components in learning environments. It describes the design of a proposed model for providing affective feedback, the mathematical validation of the conceptual model and its implementation. Moreover, it presents an analysis of the impact of the affective feedback on student motivation to learn. Finally, the book offers research perspectives of the impact and applicability of the affective feedback in computer-based tutoring environments. Affective Feedback in Intelligent Tutoring Systems can be used by human tutors who want to include motivational and affective elements in the learning process, researchers in Human-Computer Interaction and Education and by software developers who want to develop learning systems using these elements.

Published
2018

24. Role and evolution of viral tropism in patients with advanced HIV disease receiving intensified initial regimen in the ANRS 130 APOLLO trial

Author

S. Couffin-Cadiergues, Delphine Bonnet, C Merle de Boever, J. M. Livrozet, S. Ben Abdallah, Patrick Yeni, D. Makhloufi, N. El Alami Talbi, M. P. Drogoul, R. Dhote, Daniel Vittecoq, B. C. Phung, N. Benmakhlouf, S Ferrando, S Breaud, F Touam, G. Melica, Pierre Tattevin, Faouzi Souala, C. Augustin-Normand, S. Wassoumbou, F. Sanderson, I. Suaud, P. De Truchis, Jean-Claude Melchior, P. Guadagnin, D. Neau, S. Pavel, B. Warde, O. Taulera, J. Durant, B. Liauthaud, V. Gueripel, P. Sellier, C. Leport, J. L. Touraine, Sophie Leautez-Nainville, N. de Castro, M. A. Arthus, A. Rachline, S. Neuville, Charlotte Charpentier, Sophie Abgrall, M. Bonmarchand, E Aïssi, J. M. Ragnaud, J. F. Faucher, Pascal Pugliese, G. Le Facher, C. Bechara, François Raffi, L. Iordache, O. Derradji, Sophie Tabuteau, A. Frosch, François Bricaire, M. C. Pertusa, J. G. Fuzibet, Y. Mouton, S. Dominguez, P. Dion, I Perbost, Lorraine Letranchant, Jean-François Delfraissy, F. De Salvador, T. Kandel, V. Joly, C. Lascoux-Combe, Cécile Goujard, David Rey, Sylvie Radenne, Michel Dupon, Marc-Antoine Valantin, S. Stegman, F. Bastides, A Brunet, H. Aumaître, M. Lafaurie, V. Reliquet, Christine Katlama, H. Gros, R. Mansouri, J. Delgado, E. Rosenthal, J. Rivalain, G. Pialloux, Cédric Arvieux, David Boutoille, S. Gallien, G. Lepeu, S. Ferret, T. May, M. Parrinello, M. Bentata, Jean-François Bergmann, O. Aubry, J. M. Besnier, Christian Trepo, M. Vassalo, H. Kouadio, Olivier Lortholary, Jean-Albert Gastaut, H. Cordel, H. Dutronc, V. Rahelinirina, P. Lack, Jade Ghosn, Catherine Fagard, J. F. Dailloux, S. Boucherit, P. Honoré-Berlureau, J. M. Chennebault, T. Tahi, Yazdan Yazdanpanah, I. Louis, P. Le Bret, J. M. Estavoyer, J. J. Laurichesse, V. Rabier, I. Schlienger, O. Danne, Jean-Michel Molina, Bruno Hoen, B. Lebouché, Louis Bernard, D. Le, E. Peyrouse, I. Raymond, A. Gervais, Benoit Visseaux, L. Blum, C. Fontaine, Christine Burty, Y Quertainmont, M. Poupard, S Bouchez, J. J. Jourdain, C Cheneau, H. Castillo, Eric Billaud, J. M. Lang, André Cabié, A. Soufflet, J. M. Chapplain, O. Mounoury, B. Bonnet, D. Salmon-Ceron, P. Jouve, V. Mondain, P. Nau, I. Fournier, F. Bailly, J. M. Jacquet, N. Colin de Verdière, C Biron, P. Chiarello, D. Sereni, S. Pierre François, G. Fabre, Juliette Pavie, Lucile Larrouy, F. Rouges, Nathalie Colin de Verdiere, A. Rami, T. Lukiana, M. Maynard, P. Miailhes, J. Delaune, P. Abgueguen, A. Sobel, M. Revest, Clotilde Allavena, S. Herson, Olivier Bouchaud, M. Malet, H. Hüe, M. Iguertsira, A. Leplatois, Jean-Paul Viard, A. Simon, Pierre Dellamonica, Isabelle Poizot-Martin, J. Loison, E. Teicher, M. Lagrange, K. Koffi, E. Pichard, Diane Descamps, M. Ratajczak, Christian Michelet, Loïc Guillevin, A. Krivitzky, W. Kamouh, C. Chesnel, Laurence Slama, J. Cailhol, M. Partisani, N. Agher, Luminita Schneider, S. Boucly, Y. Levy, Laurent Boyer, Jacques Reynes, A. Diallo, M. Môle, N. Bennamar, Laurent Cotte, F. Brunel-Delmas, Philippe Morlat, V. Thoirain, A Foltzer, Laurent Hustache-Mathieu, H. Berthé, Jean-Daniel Lelièvre, C. Tramoni, P. Yeni, Philippe Van de Perre, M. Gory, C. Brunet-François, W. Rozenbaum, M. Saada, Christian Perronne, M. Medus, C. Chakvetadze, T. Huynh, C. Pintado, G. Pahlavan, J. L. Esnault, J. Clarissou, D. Radia, V. Frixon-Marin, E. Boulanger, F. Jeanblanc, P. Choutet, C Ceppi, V. Prendki, Sylvie Abel, Véronique Joly, A. Certain, G. Pichancourt, V. Beaujolais, O. Faucher, C Brochier, Diane Ponscarme, P. Fischer, Aurélie Beuscart, Hugues Melliez, Laboratoire de Virologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de maladies infectieuses et tropicales, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de maladies infectieuses et tropicales [Saint-Louis], Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Maladies infectieuses et tropicales, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ANRS 130 APOLLO Trial Study Group, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)

Subjects
Enfuvirtide, enfuvirtide, MESH: HIV Envelope Protein gp41, viruses, HIV Infections, Drug resistance, MESH: Antiretroviral Therapy, Highly Active, law.invention, MESH: HIV-1, Randomized controlled trial, law, Antiretroviral Therapy, Highly Active, Genotype, Pharmacology (medical), MESH: Anti-HIV Agents, MESH: Peptide Fragments, MESH: Evolution, Molecular, MESH: Aged, 0303 health sciences, MESH: Middle Aged, MESH: Drug Resistance, Viral, tropism, MESH: HIV Infections, Middle Aged, HIV Envelope Protein gp41, switch, 3. Good health, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Young Adult, medicine.drug, Adult, Microbiology (medical), Adolescent, Anti-HIV Agents, Mutation, Missense, Biology, Evolution, Molecular, resistance, Young Adult, 03 medical and health sciences, HIV DNA, Drug Resistance, Viral, medicine, Humans, In patient, Tropism, Aged, 030304 developmental biology, Pharmacology, MESH: Adolescent, MESH: Mutation, Missense, MESH: Humans, 030306 microbiology, MESH: Adult, Virology, Peptide Fragments, Viral Tropism, Regimen, HIV-1, Tissue tropism, MESH: Viral Tropism
Abstract

International audience; OBJECTIVES: The aims of the study were to assess in patients with advanced HIV disease receiving antiretroviral therapy (ART) intensification with enfuvirtide (i) resistance at virological failure (VF), (ii) impact of baseline tropism on immunovirological response, and (iii) HIV-1 DNA tropism evolution during ART. METHODS: The ANRS 130 APOLLO randomized trial evaluated in naive patients the immunovirological impact of standard ART without (control arm) or with enfuvirtide. Tropism was determined on RNA and DNA by V3-loop sequencing interpreted using the Geno2Pheno algorithm. RESULTS: At baseline the median CD4 cell count was 30 cells/mm(3). Among the 170 patients assessable in this virological substudy, HIV-1 RNA tropism was as follows: 60% of viruses were R5 and 40% were R5X4/X4. HIV-1 DNA tropism was as follows: 54% were R5 and 46% were R5X4/X4. At week 24, 39% and 49% of patients experienced VF in the enfuvirtide and control arms, respectively. In the enfuvirtide arm, only resistance-associated mutations to enfuvirtide were detected. In the control arm, two patients displayed drug-resistant viruses at the time of VF. No impact of baseline tropism was observed on immunovirological response, regardless of the study arm. Among the 25 patients experiencing DNA tropism switch between baseline and week 24, 16 (64%) switched from R5 to R5X4/X4. These latter were mostly successfully suppressed patients receiving enfuvirtide and exhibiting poorer immunological response. CONCLUSIONS: Baseline RNA tropism had no impact on the immunovirological response. Drug resistance mutations were only detected for the fusion inhibitor. Finally, the mechanism of replenishment of the viral cellular reservoir with X4 viruses observed needs to be further analysed.

Published
2013
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25. Lie nilpotency indices of symmetric elements under oriented involutions in group algebras

Author

John H. Castillo

Subjects
Involution (mathematics), Pure mathematics, General Mathematics, Group Theory (math.GR), Group algebra, Mathematics - Rings and Algebras, Computational Theory and Mathematics, Rings and Algebras (math.RA), FOS: Mathematics, Statistics, Probability and Uncertainty, Nilpotent group, 16W10, 16U80, 16U60, Mathematics - Group Theory, Mathematics
Abstract

Let $G$ be a group and let $F$ be a field of characteristic different from 2. Denote by $(FG)^+$ the set of symmetric elements and by $\mathcal{U}^+(FG)$ the set of symmetric units, under an oriented classical involution of the group algebra $FG$. We give some lower and upper bounds on the Lie nilpotency index of $(FG)^+$ and the nilpotency class of $\mathcal{U}^+(FG)$., Some corrected typos from version v2 and problems with the bibliography

Published
2012

26. A knowledge-based taxonomy of critical factors for adopting electronic health record systems by physicians: a systematic literature review

Author

Víctor H. Castillo, Ana I. Martínez-García, and J. R. G. Pulido

Subjects
Knowledge management, Attitude to Computers, business.industry, Process (engineering), Health Policy, MEDLINE, Health Informatics, lcsh:Computer applications to medicine. Medical informatics, Clinical decision support system, Health informatics, Computer Science Applications, Systematic review, Information and Communications Technology, Taxonomy (general), Health care, Electronic Health Records, Medicine, lcsh:R858-859.7, Diffusion of Innovation, Practice Patterns, Physicians', business, Research Article
Abstract

Background The health care sector is an area of social and economic interest in several countries; therefore, there have been lots of efforts in the use of electronic health records. Nevertheless, there is evidence suggesting that these systems have not been adopted as it was expected, and although there are some proposals to support their adoption, the proposed support is not by means of information and communication technology which can provide automatic tools of support. The aim of this study is to identify the critical adoption factors for electronic health records by physicians and to use them as a guide to support their adoption process automatically. Methods This paper presents, based on the PRISMA statement, a systematic literature review in electronic databases with adoption studies of electronic health records published in English. Software applications that manage and process the data in the electronic health record have been considered, i.e.: computerized physician prescription, electronic medical records, and electronic capture of clinical data. Our review was conducted with the purpose of obtaining a taxonomy of the physicians main barriers for adopting electronic health records, that can be addressed by means of information and communication technology; in particular with the information technology roles of the knowledge management processes. Which take us to the question that we want to address in this work: "What are the critical adoption factors of electronic health records that can be supported by information and communication technology?". Reports from eight databases covering electronic health records adoption studies in the medical domain, in particular those focused on physicians, were analyzed. Results The review identifies two main issues: 1) a knowledge-based classification of critical factors for adopting electronic health records by physicians; and 2) the definition of a base for the design of a conceptual framework for supporting the design of knowledge-based systems, to assist the adoption process of electronic health records in an automatic fashion. From our review, six critical adoption factors have been identified: user attitude towards information systems, workflow impact, interoperability, technical support, communication among users, and expert support. The main limitation of the taxonomy is the different impact of the adoption factors of electronic health records reported by some studies depending on the type of practice, setting, or attention level; however, these features are a determinant aspect with regard to the adoption rate for the latter rather than the presence of a specific critical adoption factor. Conclusions The critical adoption factors established here provide a sound theoretical basis for research to understand, support, and facilitate the adoption of electronic health records to physicians in benefit of patients.

Published
2010

27. ALICE: Physics Performance Report, Volume II

Author

Alessandro, B. Antinori, F. Belikov, J. A. Blume, C. and Dainese, A. Foka, P. Giubellino, P. Hippolyte, B. Kuhn, C. Martinez, G. Monteno, M. Morsch, A. Nayak, T. K. and Nystrand, J. Noriega, M. Lopez Paic, G. Pluta, J. and Ramello, L. Revol, J-P Safarik, K. Schukraft, J. Schutz, Y. Scomparin, E. Snellings, R. Baillie, O. Villalobos and Vercellin, E. Cortese, P. Dellacasa, G. Ramello, L. and Sitta, M. Ahmad, N. Ahmad, S. Ahmad, T. Bari, W. and Irfan, M. Zafar, M. Botje, M. Kuijer, P. G. Snellings, R. Belogianni, A. Christakoglou, P. Ganoti, P. Petridis, A. Roukoutakis, F. Spyropoulou-Stassinaki, M. Vassiliou, M. and Bruno, G. E. Cali, I. A. Caselle, M. De Cataldo, G. and Di Bari, D. Elia, D. Fini, R. A. Ghidini, B. Lenti, V. and Manzari, V. Mastroserio, A. Minafra, F. Nappi, E. and Navach, F. Pastore, C. Paticchio, V. Perrino, D. Posa, F. Santoro, R. Sgura, I Volpe, G. Corsi, F. De Venuto, D. Fratino, U. Marzocca, C. Tauro, A. Li, X. and Liu, Z. Lu, S. Lu, Z. Meng, Q. Sa, B. Yuan, J. and Zhou, J. Zhou, S. Alme, J. Bablok, S. Klovning, A. and Nystrand, J. Pommereesche, B. Richter, M. Rohrich, D. and Ullaland, K. Yang, H. Helstrup, H. Hetland, K. F. and Kileng, B. Roed, K. Choudhury, R. K. Dash, S. Mahapatra, D. P. Mishra, D. Phatak, S. C. Sahoo, R. Daniel, L. and Evans, D. Jones, G. T. Jovanovic, P. Jusko, A. Kinson, J. B. Platt, R. Lietava, R. Takaki, J. D. Tapia Baillie, O. Villalobos Alici, A. Antinori, S. Antoniolo, P. and Arcelli, S. Bari, G. Basile, M. Romeo, G. Cara and Cifarelli, L. Cindolo, F. Falchieri, D. Gabrielli, A. and Gandolfi, E. Hatzifotiadou, D. Laurenti, G. Luvisetto, M. I. and Nania, R. Noferini, F. Palmonari, F. Pesci, A. and Sartorelli, G. Sciolo, G. Vacca, G. P. Valenti, G. and Venturi, G. Williams, M. C. S. Zampolli, C. Zichichi, A. and Cerny, V. Janik, R. Lucan, L. Pikna, M. Pisut, J. and Pisutova, N. Sitar, B. Strmen, P. Szarka Zagiba, M. and Aiftimieri, C. Catanescu, V. Legrand, C. I. Petrovici, M. and Pop, A. Schiaua, C. Simion, V. Barnafoldi, G. and Boldizsar, L. Denes, E. Fodor, Z. Futo, E. Kiss, T. and Levai, P. Palla, G. Zimanyi, J. Atanassov, I. Basciu, S. and Cicalo, C. De Falco, A. Floris, M. Masoni, A. Mura, D. Puddu, G. Serci, S. Siddi, S. Usai, G. Badala, A. and Barbera, R. Lo Re, G. Palmeri, A. Pappalardo, G. S. and Pulvirenti, A. Riggi, F. Anelli, G. Augustin, I. and Augustinus, A. Baechler, J. Belikov, J. A. Betev, L. and Boccardi, A. Brun, R. Burns, M. Buncic, P. Campagnolo, R. Campbell, M. Carena, F. Carena, W. Carminati, F. and Chapeland, S. Cheshkov, C. Chochula, P. Christiansen, P. and Colla, A. Belbute, B. F. Correia Davenport, M. de Groot, J. and Di Mauro, A. Divia, R. Engster, C. Evrard, S. and Fabjan, C. W. Feng, L. Flierl, D. Formenti, F. Fuchs, U. and Garcia Lopez, A. Gheata, A. Gheata, M. and Gonzalez-Gutierrez, C. Grosso, R. Gruwe, M. Gustafsson, H. A. Hoedelmoser, H. Hristov, P. Ivanov, M. Jirden, L. and Jorgensen, C. Junique, A. Kapusta, S. Kickinger, W. and Klempt, W. Kluge, A. Leistam, L. Lo, J. P. Noriega, M. Lopez Lourenco, C. Makhylyueve, I. Marin, J. C. and Martinengo, P. Meunier-Picard, D. Meoni, M. Morel, M. and Morsch, A. Mota, B. Muller, H. Musa, L. Nayak, T. K. and Nilsson, P. Nouais, D. Osmic, F. Perini, D. Pestotnik, R. Peters, A. Morais, V. Pinto Popescu, S. Rademakers, F. Revol, J. P. Riedler, P. Riegler, W. Safarik, K. and Schossmaier, K. Schukraft, J. Schutz, Y. Silva Loureiro, P. A. Soos, C. Stefanini, G. Swoboda, D. Tadel, M. and Taureg, H. Tavlet, M. Tissot-Daguette, P. de Matos, C. Torcato Vande Vyvre, P. Vanuxem, J. P. Aggarwal, M. M. and Bhati, A. K. Kumar, A. Sharma, M. Sood, G. Baldit, A. and Barret, V. Bastid, N. Blanchard, G. Castor, J. and Crochet, P. Daudon, F. Devaux, A. Dupieux, P. Force, P. and Grigoryan, S. Guerin, F. Guerin, F. Guernane, R. and Insa, C. Jouve, F. Lecoq, J. Manso, F. Rosnet, P. and Royer, L. Saturnini, P. Savinel, G. Humanic, T. J. and Kotov, I. V. Lisa, M. Nilsen, B. S. Truesdale, D. and Johnson, D. Bearden, I. Boggild, H. Christensen, C. H. and Gaardhoje, J. J. Gulbrandtsen, K. Nielsen, B. S. Renault, G. and Bartke, J. Gladysz-Dziadus, E. Kornas, E. Kowalski, M. and Rybicki, A. Wroblewski, A. Andronic, A. Antonczyk, D. and Badura, E. Bailhache, R. Berdermann, E. Braun-Munzinger, P. Busch, O. Ciobanu, M. Foka, P. Frankenfeld, U. and Garabatos, C. Gutbrod, H. Lippmann, C. Malzacher, P. and Marin, A. Miskowiec, D. Radomski, S. Schmidt, H. R. and Schwarz, K. Sedykh, K. Simon, R. S. Soyk, D. Stelzer, H. and Stockmeier, M. Tziledakis, G. Vranic, D. Wiechula, J. and Bonnes, U. Kraus, I. Oeschler, H. Appelshauser, H. and Blume, C. Dietel, T. Gazdzicki, M. Hartig, M. Kliemant, M. Kniege, S. Kolleger, T. Kramer, F. Lange, F. and Loizides, C. Ploskon, M. Renfordt, R. Sommer, W. Stock, R. Strobele, H. Berdnikov, Ya Ivanov, V Khanzadeev, A. and Miftakhov, N. Nicoulin, V. Polyakov, V. Rostchin, E. and Samsonov, V. Tarasenkova, O. Tarakanov, V. Zhalov, M. and Lopez Torres, E. Abrahantes Quintana, A. Diaz Valdes, R. and Angelov, T. Alt V. Cuveland, J. Gutfleish, M. Kalcher, S. and Lindenstruth, V. Panse, R. Reichling, C. Schneider, R. and Steinbeck, T. Troger, H. Tilsner G. Wiebalck, A. Adler, C. Emschermann, D. Glassel, P. Herrmann, N. Ludolphs, W. and Mahmoud, T. Mercado, J. Milosevic, J. Oyama, K. and Rusanov, I. Schnicker, R. Shukla, P. Soltveit, H. C. and Stachel, J. Vulpescu, B. Windelband, B. Yurevich, S. and Shigaki, K. Sugitate, T. Raniwala, S. Badyal, S. K. and Bala, R. Bhasin, A. Gupta, A. Gupta, V. K. Mahajan, S. and Mangotra, L. K. Potukuchi, B. V. K. S. Sambyal, S. S. and Akichine, P. G. Arefiev, V. A. Baatar, T. Batiounia, B. V. and Chepurnov, V. F. Chernenko, S. A. Dodokhov, V. K. and Fateev, O. V. Fedunov, A. G. Haiduc, M. Hasegun, D. and Kadychevsky, V. G. Kharadze, G. Khurelbaatar, B. and Koshurnikov, E. K. Lioubochits, V. C. Lobanov, V. I. and Malinina, L. V. Minaev, Y. I. Nioradze, M. Nomokonov, P. V. and Panebrattsev, Y. A. Penev, V. N. Pismennaya, V. G. and Pocheptsov, T. A. Roufanov, I. Shabratova, G. S. Shestakov, V. Shkloskaya, A. I. Sorin, A. S. Suleimanov, M. K. and Tevzadze, Y. Togoo, R. Vodopianov, A. S. Yurevich, V. I. and Zanevsky, Y. V. Zaporojets, S. A. Zinchenko, A. I. Aysto, J. and Bondila, M. Lyapin, V. Oinonen, M. Malkiewicz, T. and Ruuskanen, V. Seppanen, H. Trzaska, W. Yamaletkinov, S. and Jung, H. T. Jung, W. Kim, D. W. Kim, H. N. Kim, J. S. and Lee, K. S. Lee, S. C. Blank, T. Gemmeke, H. Bochek, G. L. Dovbnya, A. N. Kulibaba, V. I. Maslov, N. I. and Naumov, S. V. Ovchinnik, V. D. Potin, S. M. Starodubtsev, A. F. Borshchov, V. N. Chykalov, O. Kaurova, L. Kiprich, S. K. Klymova, L. Listratenko, O. M. Mykhylova, M. and Protenko, M. Reznik, O. Starkov, V. E. Kadenko, I. and Martynov, Y. Molodtsov, S. Sinyukov, Y. Zinovjev, G. and Bhattacharya, P. Bose, S. Chatterjee, S. Chattopadhyay, S. and Das, D. Das, I. Dutt-Mazumder, A. K. Majumdar, N. and Mukhopadhyay, S. Pal, S. Paul, L. Roy, P. Sanyal, A. and Sarkar, S. Sen, P. Sen, S. K. Sinha, B. C. Sinha, T. and Ahammed, Z. Bhaskar, P. Chattopadhyay, S. Das, D. Das, S. Majumdar, M. R. Dutta Ganti, M. S. Ghosh, P. Mohanty, B. Netrakanti, P. K. Pal, S. Singaraju, R. N. Singhal, V. Sinha, B. Viyogi, Y. P. Hartung, G. Krawutschke, T. and Ban, J. Bombara, M. Dirner, A. Hnatic, M. Kralik, I. and Kravcakova, A. Krivan, F. Krivda, M. Martinska, G. and Pastircak, B. Sandor, L. Urban, J. Vrlakova, J. and Cinausero, M. Fioretto, E. Prete, G. Ricci, R. A. and Vannucci, L. Branco, P. Carvalho, R. Seixas, J. Vilela Mendes, R. Oskarsson, A. Osterman, L. Otterlund, I. and Stenlund, E. A. Cheynis, B. Ducroux, L. Grossiord, J. Y. and Guichard, A. Pillot, P. Rapp, B. Tieulent, R. Molina, J. R. Alfaro Ayala, A. Moreno, E. Belmont Contreras, J. G. and Cuautle, E. D'Olivo, J. C. Dominguez, I. Flores, A. and Grabski, V. Corral, G. Herrera Linares, M. Martinez, M. I. and Martinez Davalos, A. Menchaca-Rocha, A. Montano Zetina, L. M. Nellen, L. Paic, G. del Pino, J. Reyes, P. and Sandoval, A. Vergara, S. Zepeda, A. Feshchenko, V. A. and Golubeva, M. B. Gorlychev, V. G. Guber, F. F. Karavichev, O. V. Karavicheva, T. L. Karpechev, E. V. Kurepin, A. B. and Maevskaya, A. I. Marin, V. V. Pshenichnov, I. A. Razin, V. I. Reshetin, A. I. Shileev, K. A. Topil'skaia, N. S. and Akindinov, A. N. Golovine, V. Kaidalov, A. B. Kats, M. M. and Kiselev, I. T. Kisselev, S. M. Lioublev, E. Martemianov, M. Martemiyanov, A. N. Polozov, P. A. Serov, V. S. and Smirnitski, A. V. Tchoumakov, M. M. Vetlitski, I. A. and Volochine, K. G. Vorobiev, L. S. Zagreev, B. V. Aleksandrov, D. Antonenko, V. Beliaev, S. Fokine, S. Ippolitov, M. and Karadjev, K. Koutcheriaev, I. Lebedev, V. Manko, V. I. and Moukhanova, T. Nianine, A. Nikolaev, S. Nikouline, S. and Patarakine, O. Peressounko, D. Sibiriak, I. Tsvetkov, A. and Vasiliev, A. Vinogradov, A. Yushmanov, I Grigoriev, V. A. Kaplin, V. A. Loginov, V. A. Nandi, B. K. Varma, R. and Chandratre, V. Kataria, V. Baumann, C. Glasow, R. and Gottschlag, H. Grosse-Oetringhaus, J. F. Heine, N. and Klein-Bosing, C. Reygers, K. Santo, R. Verhoeven, W. and Wessels, J. Wilk, A. Aphecetche, L. Berny, R. Bouvier, S. Conesa-Balbastre, G. Conesa-del-Valle, Z. Cussonneau, J. P. Delagrange, H. Dialinas, M. Finck, C. Erazmus, B. and Germain, M. Lefevre, F. Luquin, L. Martinez, G. Renard, C. Roy, C. Tournaire, A. Frolov, A. R. Pestov, I. N. and Awes, T. Cherney, M. Gorbunov, Y. Bimbot, L. Chambert, V. Charpy, A. Comets, M. P. Courtat, P. Drouet, S. and Edelbruck, P. Espagnon, B. Hfrivnacova, I. Kunne, R. Le Bornec, Y. Mac Cormick, M. Peyre, J. Pouthas, J. and Bravina, L. Lovhoiden, G. Skaali, B. Tveter, T. S. Vik, T. Antinori, F. Dainese, A. Dima, R. Fabris, D. and Faivre, J. Lunardon, M. Morando, M. Moretto, S. Pepato, A. Quercigh, E. Scarlassara, F. Segato, G. Turrisi, R. and Viesti, G. Choi, J. Beitlerova, A. Mares, J. Polak, K. Zavada, P. Petracek, V. Pachr, M. Skoda, L. and Bogolyubsky, M. Yu Khaoustov, G. V. Kharlov, Yu V. Minaev, N. G. Petrov, V. S. Polichtchouk, B. V. Sadovsky, S. A. and Senko, V. A. Soloviev, A. S. Stolpovsky, P. V. Victorov, V. A. Fernandez Tellez, A. Gamez Flores, E. Lopez-Ramirez, R. and Ortiz-Velczquez, A. Pagliarone, C. Roman-Lopez, S. and Tejeda-Munoz, G. Vargas, A. Villasenor Cendejas, L. Adamova, D. Kouchpil, S. Kouchpil, V. Kugler, A. Sumbera, M. and Wagner, V. Di Liberto, S. Mazzoni, M. A. Meddi, F. and Urciuoli, G. M. Cleymans, J. de Vaux, G. Fearick, R. W. and Szostak, A. Vilakazi, Z. Z. Anfreville, M. Baldisseri, A. and Becker, B. Borel, H. Castillo, J. Charvet, J. L. and Combet, M. Gosset, J. Hardy, P. Herlant, S. Orsini, F. and Penichot, Y. Pereira, H. Staley, F. M. Usseglio, M. and De Caro, A. De Gruttola, D. De Pasquale, S. Di Bartolomeo, A. Girard, M. Fusco Grella, G. Guarnaccia, C. Guida, M. and Romano, G. Sellitto, S. Silvestri, R. Virgili, T. and Basmanov, V. Budnikov, D. Demanov, V. Ianowski, V. and Ilkaev, R. Ivanov, A. Khlebnikov, A. Kouryakin, A. and Mikhailov, E. Nazarenko, S. Pavlov, V. Philchagin, S. and Punin, A. Punin, V. Poutevskoi, S. Rybin, A. Selin, I. and Smetanin, M. Telnov, A. Treskov, S. Vikhlyantsev, O. and Vinogradov, I Vyushin, A. Zavyalov, N. Zhelezov, S. and Zhitnik, A. Gotovac, S. Mudnic, E. Vidak, L. Asryan, A. G. Braun, M. A. Derkach, D. A. Feofilov, G. A. Igolkin, S. N. Ivanov, A. S. Kolevatov, R. S. Kolojvari, A. A. and Kondratiev, V. P. Naumenko, P. A. Toulina, T. A. Valiev, F. F. Vechernin, V. V. Vinogradov, L. I. Baudot, J. Bonnet, D. Coffin, J. P. Estienne, M. Hippolyte, B. Kuhn, C. and Lutz, J. R. Vernet, R. Hamagaki, H. Ozawa, K. Bonvicini, V. Borysov, O. Bosisio, L. Bregant, M. Camerini, P. and Contin, G. Faleschini, F. Fragiacomo, E. Grion, N. and Margagliotti, G. Piano, S. Rachevskaya, I. Rachevski, A. and Rui, R. Vacchi, A. Alessandro, B. Arnaldi, R. Bagnasco, S. Batigne, G. Beole, S. Bruna, E. Cerello, P. and Chiavassa, E. Cobanoglu, O. Coli, S. Crescio, E. De Marco, N. De Remigis, P. Ferretti, A. Gagliardi, M. and Gallio, M. Gaudichet, L. Gemme, R. Giraudo, G. and Giubellino, P. Idzik, M. Martoiu, S. Chiesa, A. Marzari and Masera, M. Mazza, G. Mereu, P. Monteno, M. Musso, A. and Oppedisano, C. Piccotti, A. Poggio, F. Prino, F. and Riccati, L. Rivetti, A. Scomparin, E. Stocco, D. and Tosello, F. Toscano, L. Travaglia, G. Vercellin, E. and Werbrouck, A. Wheadon, R. Yermia, F. Miake, Y. Esumi, S. and Buskop, J. J. F. De Haas, A. P. Ivan, C. Kamermans, R. and Mischke, A. Nooren, G. Oskamp, C. J. Peitzmann, Th. and Simili, E. Sokolov, O. Van Den Brink, A. Van Eijndhoven, N. and Enyo, H. Fujiwara, K. Kano, H. Onishi, H. Deloff, A. and Dobrowolski, T. Karpio, K. Malek, M. Malinowski, H. and Redlich, K. Siemiarczuk, T. Stefanek, G. Tykarski, L. and Wilk, G. Chajecki, Z. Gos, H. Janik, M. Jedynak, M. and Kisiel, A. Pawlak, T. J. Peryt, W. S. Pluta, J. and Skowronski, P. Slodkowski, M. Szuba, P. Traczyk, T. and Conner, E. S. Keidel, R. Cai, X. Ding, H. T. Liu, H. and Wang, X. R. Yang, H. Y. Yin, Z. B. Zhou, D. C. Cao, X. and Li, Q. Liu, Y. Z. Su, G. Tan, L. Zhu, G. X. and Atayan, M. Grigoryan, A. Gulkanyan, H. Harutyunyan, A. and Hayrapetyan, A. Kakoyan, V. Poghosyan, M. Sargsyan, G. and Anticic, T. Kadija, K. Susa, T. Arleo, F. Armesto, N. and Aurenche, P. Benhabib, L. Bogdanov, A. Borghini, N. and Carrer, N. Csorgo, T. Gupta, S. Heinz, U. W. Jacobs, P. M. Lednicky, R. Letessier, J. Mrowczynski, S. Rafelski, J. Ranft, J. Silvermyr, D. Wiedemann, U. A. Scapparone, E. ALICE Collaboration

Subjects
Nuclear Experiment
Abstract

ALICE is a general-purpose heavy-ion experiment designed to study the physics of strongly interacting matter and the quark-gluon plasma in nucleus-nucleus collisions at the LHC. It currently involves more than 900 physicists and senior engineers, from both the nuclear and high-energy physics sectors, from over 90 institutions in about 30 countries. The ALICE detector is designed to cope with the highest particle multiplicities above those anticipated for Pb-Pb collisions (dN(ch)/dy up to 8000) and it will be operational at the start-up of the LHC. In addition to heavy systems, the ALICE Collaboration will study collisions of lower-mass ions, which are a means of varying the energy density, and protons (both pp and pA), which primarily provide reference data for the nucleus-nucleus collisions. In addition, the pp data will allow for a number of genuine pp physics studies. The detailed design of the different detector systems has been laid down in a number of Technical Design Reports issued between mid-1998 and the end of 2004. The experiment is currently under construction and will be ready for data taking with both proton and heavy-ion beams at the start-up of the LHC. Since the comprehensive information on detector and physics performance was last published in the ALICE Technical Proposal in 1996, the detector, as well as simulation, reconstruction and analysis software have undergone significant development. The Physics Performance Report (PPR) provides an updated and comprehensive summary of the performance of the various ALICE subsystems, including updates to the Technical Design Reports, as appropriate. The PPR is divided into two volumes. Volume I, published in 2004 (CERN/LHCC 2003-049, ALICE Collaboration 2004 J. Phys. G: Nucl. Part. Phys. 30 1517-1763), contains in four chapters a short theoretical overview and an extensive reference list concerning the physics topics of interest to ALICE, the experimental conditions at the LHC, a short summary and update of the subsystem designs, and a description of the offline framework and Monte Carlo event generators. The present volume, Volume II, contains the majority of the information relevant to the physics performance in proton-proton, proton-nucleus, and nucleus-nucleus collisions. Following an introductory overview, Chapter 5 describes the combined detector performance and the event reconstruction procedures, based on detailed simulations of the individual subsystems. Chapter 6 describes the analysis and physics reach for a representative sample of physics observables, from global event characteristics to hard processes.

Published
2006

28. Electromagnetic nucleon form factors from QCD sum rules

Author

Marcelo Loewe, H. Castillo, Cesareo A. Dominguez, Department of Physics, and Faculty of Science

Subjects
Quark, Quantum chromodynamics, Physics, Nuclear and High Energy Physics, Particle physics, QCD sum rules, Electromagnetic processes and properties, QCD, phenomenological models, High Energy Physics::Lattice, Dirac (software), High Energy Physics::Phenomenology, Form factor (quantum field theory), FOS: Physical sciences, symbols.namesake, High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), Pauli exclusion principle, symbols, Perturbation theory (quantum mechanics), Nucleon
Abstract

The electromagnetic form factors of the nucleon, in the space-like region, are determined from three-point function Finite Energy QCD Sum Rules. The QCD calculation is performed to leading order in perturbation theory in the chiral limit, and to leading order in the non-perturbative power corrections. The results for the Dirac form factor, $F_1(q^2)$, are in very good agreement with data for both the proton and the neutron, in the currently accessible experimental region of momentum transfers. This is not the case, though, for the Pauli form factor $F_2(q^2)$, which has a soft $q^2$-dependence proportional to the quark condensate $$., Replaced Version. An error has been corrected in the numerical evaluation of the Pauli form factor. This changes the results for F_2(q^2), as well as the conclusions

Published
2003

29. EP02.12: Descriptive study of vitamin D deficiency in a non‐supplemented Mediterranean cohort of pregnant women: the IMPACT‐BCN trial.

Author

Espín, H. Castillo, Quintanilla, L. Benitez, Crovetto, F., Sola, M. Larroya, Castro‐Barquero, S., Gomez, S., Casas, I., Casas, R., Estruch, R., Gratacos, E., and Crispi, F.

Abstract

At 20-24 weeks of gestation, the mean vitamin D level was 21.2 (SD 9.8), and 189 women (71.1%) had a low circulating vitamin D level. Vitamin D deficiency and insufficiency are very common in women around the globe. EP02.12: Descriptive study of vitamin D deficiency in a non-supplemented Mediterranean cohort of pregnant women: the IMPACT-BCN trial. [Extracted from the article]

Published
2022
Full Text
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30. Liderazgo y satisfacción en el trabajo: ¿Vale la pena estudiarlos?

Author

Alamillo, Alfonso Aldape, Pedrozo, Jorge, Pérez, Velia H. Castillo, and de Jesús Moguel Liévano, Manuel

Abstract

Copyright of Pretium: Revista de Economía, Negocios y Finanzas is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011

31. Multicentre randomised trial of screening with sFlt1/PlGF and planned delivery to prevent pre-eclampsia at term: protocol of the PE37 study

Author

M Timmermans, Josefina Mora, Francesc Figueras, I Casas, H Castillo, Eduard Gratacos, Ladislav Krofta, Francesca Crovetto, Fatima Crispi, Carmina Comas, Alicia Martínez-Varea, Anna Kajdy, Elisa Llurba, Lina Youssef, Juan Luis Delgado, Isabel Puig, Katerina Mackova, Albert Tubau, Aina Ruiz, Antoni Paya, Maria Prat, Frederic Chantraine, Maria Fernanda Lopez-Tinajero, RJ Campos, V Parriego, D Sys, and J Modzelewski

Subjects
Medicine
Abstract

Introduction Pre-eclampsia affects ~5%–7% of pregnancies. Although improved obstetric care has significantly diminished its associated maternal mortality, it remains a leading cause of maternal morbidity and mortality in the world. Term pre-eclampsia accounts for 70% of all cases and a large proportion of maternal–fetal morbidity related to this condition. Unlike in preterm pre-eclampsia, the prediction and prevention of term pre-eclampsia remain unsolved. Previously proposed approaches are based on combined third-trimester screening and/or prophylactic drugs, but these policies are unlikely to be widely implementable in many world settings. Recent evidence shows that the soluble fms-like tyrosine kinase-1 (s-Flt-1) to placental growth factor (PlGF) ratio measured at 35–37 weeks’ gestation predicts term pre-eclampsia with an 80% detection rate. Likewise, recent studies demonstrate that induction of labour beyond 37 weeks is safe and well accepted by women. We hypothesise that a single-step universal screening for term pre-eclampsia based on sFlt1/PlGF ratio at 35–37 weeks followed by planned delivery beyond 37 weeks reduces the prevalence of term pre-eclampsia without increasing the caesarean section rates or worsening the neonatal outcomes.Methods and analysis We propose an open-label randomised clinical trial to evaluate the impact of a screening of term pre-eclampsia with the sFlt-1/PlGF ratio followed by planned delivery in asymptomatic nulliparous women at 35–37 weeks. Women will be assigned 1:1 to revealed (sFlt-1/PlGF known to clinicians) versus concealed (unknown) arms. A cut-off of >90th centile is used to define the high risk of subsequent pre-eclampsia and offer planned delivery from 37 weeks. The efficacy variables will be analysed and compared between groups primarily following an intention-to-treat approach, by ORs and their 95% CI. This value will be computed using a Generalised Linear Mixed Model for binary response (study group as fixed effect and the centre as intercept random effect).Ethics and dissemination The study is conducted under the principles of Good Clinical Practice. This study was accepted by the Clinical Research Ethics Committee of Hospital Clinic Barcelona on 20 November 2020. Subsequent approval by individual ethical committees and competent authorities was granted. The study results will be published in peer-reviewed journals and disseminated at international conferences.Trial registration number NCT04766866.

Published
2024
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32. Evaluation of the Microwave Absorption Properties of Solid Dehydrated and Powdered Agricultural Waste at X-Band Frequencies

Author

Jorge Simon, Emmanuel Hernandez-Gonzalez, Juvenal Villanueva-Maldonado, Gustavo Vera-Reveles, Pablo-Armando Alcaraz-Valencia, Victor H. Castillo-Topete, Leonel Soriano-Equigua, Fermin Marcelo Maciel-Barboza, Jorge Flores-Troncoso, Jose Ricardo Gomez-Rodriguez, Marco Cardenas-Juarez, and Jose Alvarez-Flores

Subjects
Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Cellular telephone services industry. Wireless telephone industry, HE9713-9715
Abstract

In this article, a comparison of the absorption properties of 7 common agricultural waste materials from the state of Colima in Mexico is performed. The study carried out at X-band frequencies finds that the highest absorption levels were mainly from 8 to 10.5 GHz. The experiment, based on a WR-90 waveguide with samples inserted in holders in the middle of it, shows that papaya peel and lemon peel had the highest absorption levels in the aforementioned frequency range. This study is relevant because of the vast amount of agricultural waste generated in such state of Mexico, that can be used as absorbers in the microwave regime, and not managed as garbage. In this work, the feasibility of using these eco-friendly and nontoxic materials as microwave absorbers instead of typical commercial synthetic materials is evaluated.

Published
2024
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33. Use of Synchrotron-Based Techniques to Elucidate Metal Uptake and Metabolism in Plants.

Author

Sarret, G., Smits, E.A.H. Pilon, Michel, H. Castillo, Isaure, M.P., Zhao, F.J., and Tappero, R.

Subjects
*PLANT metabolism, *CHEMICAL composition of plants, *X-ray fluorescence, *SYNCHROTRONS, *PLANT cells & tissues, *INDUCTIVELY coupled plasma mass spectrometry
Abstract

Synchrotron techniques have become key components of the toolbox for studying the mechanisms involved in metal(loid) uptake and metabolism in plants. Most widely used techniques in this field include micro-X-ray fluorescence (µXRF) for imaging the distribution of elements in plant tissues and cells and quantifying them, and X-ray absorption spectroscopy (XAS) for determining their chemical forms. Recent advances in terms of spatial resolution, sensitivity and versatility of the sample environment have opened new perspectives for the study of trace elements at the micro- and nanoscale with a minimal perturbation of the sample. Sample conditioning remains a key issue for the study of metals in plants. Cryogenic sample environments allow work on hydrated systems, with a limited risk of metal remobilization and changes in speciation. Still, radiation damage should be monitored carefully, especially for high-flux spectrometers. In addition, progress in software for data analysis has facilitated data mining and integration of results from various techniques. This chapter presents the principle and the basics of data analysis for µXRF imaging and tomography, XAS and micro-Fourier transform infrared spectromicroscopy (µFTIR). Major results obtained on Ni, Cd, Zn, Se, As, Cu, Mn and nanoparticles in hyperaccumulating and nonaccumulating plants are presented. Complementary approaches including histochemical techniques, micro and nanoscopic techniques using electron- or ion beams, and laser ablation coupled with inductively coupled plasma mass spectrometry (ICP-MS) are also presented, and key results reviewed. Finally, there is also great interest in coupling synchrotron techniques, which is possible on more and more beamlines, and also in coupling synchrotron techniques with other approaches such as the ones mentioned above; perspectives in this area are discussed. [ABSTRACT FROM AUTHOR]

Published
2013
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34. Prolactin increases cell migration of MCF-7 cells without inducing an epithelium-mesenchyme transition

Author

Jesús A. Lara-Reyes, Zuleima H. Castillo-García, Gonzalo E. Aranda-Abreu, Deissy Herrera-Covarrubias, Clara L. Sampieri-Ramírez, Arnoldo Aquino-Gálvez, Jorge M. Suárez-Medellín, Ma. Elena Hernández-Aguilar, and Fausto Rojas-Durán

Subjects
Prolactin. MCF-7 cells. Epithelial-mesenchymal transition. Cell migration assays. Cell movement. Breast neoplasms., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objective: To evaluate the effect of prolactin (PRL) on the migration of MCF-7 breast cancer cells and the expression of E-cadherin. Methods: We used the wound healing assays to evaluate the migration of MCF-7 cells and the Western blot technique to evaluate the expression of E-cadherin. Results: The results show that PRL produced an increase in the migration of MCF-7 cells without inducing a reduction in the expression of E-cadherin. Conclusions: Prolactin significantly increased the migration of MCF-7 breast cancer cell line without inducing an epithelial-mesenchymal transition (EMT), which could be related to a collective type of migration.

Published
2022
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36. Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates.

Author

Lanoizelet M, Michel L, Lagadec R, Mayeur H, Guichard L, Logeux V, Séverac D, Martin K, Klopp C, Marcellini S, Castillo H, Pollet N, Candal E, Debiais-Thibaud M, Boisvert C, Billoud B, Schubert M, Blader P, and Mazan S

Subjects
Animals, Neurogenesis genetics, Body Patterning genetics, Mice, Gene Expression Regulation, Developmental, Vertebrates genetics, Biological Evolution, Wnt Proteins metabolism, Wnt Proteins genetics, Neurons metabolism, Transcriptome, Nodal Protein metabolism, Nodal Protein genetics, Habenula metabolism, Sharks genetics, Sharks embryology, Sharks anatomy & histology, Wnt Signaling Pathway, Zebrafish genetics
Abstract

The mode of evolution of left-right asymmetries in the vertebrate habenulae remains largely unknown. Using a transcriptomic approach, we show that in a cartilaginous fish, the catshark Scyliorhinus canicula, habenulae exhibit marked asymmetries, in both their medial and lateral components. Comparisons across vertebrates suggest that those identified in lateral habenulae reflect an ancestral gnathostome trait, partially conserved in lampreys, and independently lost in tetrapods and neopterygians. Asymmetry formation involves distinct mechanisms in the catshark lateral and medial habenulae. Medial habenulae are submitted to a marked, asymmetric temporal regulation of neurogenesis, undetectable in their lateral counterparts. Conversely, asymmetry formation in lateral habenulae results from asymmetric choices of neuronal identity in post-mitotic progenitors, a regulation dependent on the repression of Wnt signaling by Nodal on the left. Based on comparisons with the mouse and the zebrafish, we propose that habenular asymmetry formation involves a recurrent developmental logic across vertebrates, which relies on conserved, temporally regulated genetic programs sequentially shaping choices of neuronal identity on both sides and asymmetrically modified by Wnt activity., Competing Interests: Competing interests: The authors declare no competing interest., (© 2024. The Author(s).)

Published
2024
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37. Laparotomy-assisted, two-port fetoscopic myelomeningocele repair: infant to preschool outcomes.

Author

Sanz-Cortes M, Whitehead WE, Johnson RM, Aldave G, Castillo H, Desai NK, Donepudi R, Joyeux L, King A, Kralik SF, Lepard J, Mann DG, McClugage SG, Nassr AA, Naus C, Nguyen G, Castillo J, Ravindra VM, Sutton CD, Weiner HL, and Belfort MA

Abstract

Objective: This study reports the infant to preschool outcomes of a laparotomy-assisted, two-port fetoscopic myelomeningocele (MMC) repair and compares the results with those of a contemporary, same-center cohort that underwent either fetal MMC surgery via hysterotomy or postnatal MMC repair., Methods: All MMC closures between December 2011 and July 2021 were screened. Singleton pregnancies with hindbrain herniation and MMC between T1 and S1 were included. Fetuses were excluded for genetic abnormalities, severe kyphosis, and other congenital anomalies. The pregnant woman determined the method of MMC repair (fetoscopic, hysterotomy, or postnatal repair)., Results: Two hundred MMC closures met the study criteria (100 fetoscopic, 41 hysterotomy, and 59 postnatal). The median length of follow-up was beyond 46 months for all groups. The median gestational age at delivery was 38.1 weeks (IQR 35.1, 39.1 weeks) for the fetoscopic group, 35.7 weeks (IQR 33.6, 37.0 weeks) for the hysterotomy group, and 38.6 weeks (IQR 37.7, 39.0 weeks) for the postnatal group. Vaginal delivery occurred in 51% of the fetoscopic cases, and there were no instances of uterine dehiscence or rupture. Treatment for hydrocephalus in the 1st year occurred in 35% (95% CI 27%-50%) of fetoscopic, 33% (95% CI 20%-50%) of hysterotomy, and 81% (95% CI 70%-90%) of postnatal repair cases. At 30 months, patients who underwent fetal intervention were twice as likely to be community ambulators (with or without devices) as those who underwent postnatal repair (52% [95% CI 42%-62%] of fetoscopic, 54% [95% CI 39%-68%] of hysterotomy, and 24% [95% CI 14%-36%] of postnatal cases). Surgery for symptomatic tethered cord occurred in 12% (95% CI 7%-19%) of fetoscopic, 17% (95% CI 8%-31%) of hysterotomy, and 2% (95% CI 1%-8%) of postnatal repair cases. Surgery for symptomatic spinal inclusion cysts was required in 4% (95% CI 1%-9%) of fetoscopic, 7% (95% CI 2%-18%) of hysterotomy, and none (95% CI 0%-8%) of the postnatal cases., Conclusions: Laparotomy-assisted, two-port fetoscopic repair provides significant benefits for maternal health. It negates the risk of uterine rupture for the index pregnancy and subsequent pregnancies and allows for vaginal delivery. The benefits to the fetus are the same as those of hysterotomy repairs, with a lower risk of prematurity. There was no difference in the rate of surgery for tethered cord or spinal inclusion cysts between fetoscopic and hysterotomy procedures. Overall, laparotomy-assisted, two-port fetoscopic repair is safer for the fetus and the mother than fetal MMC surgery via hysterotomy.

Published
2024
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38. Assessment of Ventricular Size and Neurocognitive Outcomes in Children with Postnatal Closure of Myelomeningocele.

Author

Lai GY, Pfeifle GB, Castillo H, Harvey J, Farless C, Davis T, Castillo J, and Gupta N

Subjects
Humans, Retrospective Studies, Female, Male, Child, Cerebrospinal Fluid Shunts, Organ Size, Meningomyelocele surgery, Meningomyelocele complications, Hydrocephalus surgery, Cerebral Ventricles surgery, Neuropsychological Tests
Abstract

Objective: To assess if ventricular size before shunting is correlated with neurodevelopmental outcomes in children with postnatal myelomeningocele closure., Study Design: This retrospective review included children with postnatal surgical closure of myelomeningocele and neuropsychological testing between 2018 and 2023 at the University of California, San Francisco. Frontal-occipital horn ratio (FOHR) was measured immediately before shunt placement or on the first study that reported ventricular stability for nonshunted patients. The primary outcome was full scale IQ (FSIQ) on the Weschler Intelligence Scale. Secondary outcomes included indices of the Weschler scale, the Global Executive Composite from the Behavior Rating Inventory of Executive Function, and the general adaptive composite from the Adaptive Behavior Assessment Scale. Univariable and multivariable regression was used to determine if FOHR was correlated with neuropsychological scores., Results: Forty patients met the inclusion criteria; 26 (65%) had shunted hydrocephalus. Age at neuropsychological testing was 10.9 ± 0.6 years. FOHR was greater in the shunted group (0.64 vs 0.51; P < .001). There were no differences in neuropsychological results between shunted and nonshunted groups. On univariable analysis, greater FOHR was associated with lower FSIQ (P = .025) and lower Visual Spatial Index scores (P = .013), which remained significant on multivariable analysis after adjusting for gestational age at birth, lesion level, shunt status, and shunt revision status (P = .049 and P = .006, respectively). Separate analyses by shunt status revealed that these effects were driven by the shunted group., Conclusions: Greater FOHR before shunting was correlated with lower FSIQ and the Visual Spatial Index scores on the Weschler Intelligence Scales. Larger studies are needed to explore further the relationship between ventricle size, hydrocephalus, and neurodevelopmental outcomes., Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest. Funding: There was no funding for this study., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Published
2024
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39. Predicting Additional Metastases in Axillary Lymph Node Dissection After Neoadjuvant Chemotherapy: Ratio of Positive/Total Sentinel Nodes.

Author

Cebrecos I, Torras I, Castillo H, Pumarola C, Ganau S, Sitges C, Vidal-Sicart S, Schettini F, Sanfeliu E, Loinaz I, Garcia M, Oses G, Molla M, Vidal M, and Mension E

Abstract

Background/objectives: The aim of the study was to determine the clinical value of the sentinel lymph node ratio (SLN-R) in predicting additional positive lymph nodes during axillary lymph node dissection (ALND) in breast cancer patients following neoadjuvant chemotherapy (NAC)., Methods: A cross-sectional study was performed at a single institution evaluating data from 1521 BC patients. Inclusion criteria comprised cT1/cT4, cN0/cN1 status with positive post-NAC axillary staging by SLN/TAD, respectively, and subsequent ALND., Results: The study included 118 patients, divided into two groups based on the presence or absence of additional node metastasis at ALND: 39 in the residual disease group (RD) and 79 in the non-residual disease group (nRD). Univariate logistic regression analysis of SLN-R was conducted to assess its predictive value, yielding an odds ratio (OR) of 7.79 (CI 1.92-29.5, p = 0.003). An SLN-R cut-off point of <0.35 was identified using ROC curve analysis, with a false-negative rate of 10.2%, as a predictor for no additional metastasis at ALND following post-NAC SLN/TAD positivity., Conclusions: The study concludes that SLN-R is a valuable predictor for determining the omission of ALND in cases where SLN/TAD is positive after NAC. This metric, in combination with other clinical variables, could help develop a nomogram to spare patients from ALND.

Published
2024
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40. Association between social determinants of health and select neurosurgical procedures in the National Spina Bifida Patient Registry.

Author

Punchak MA, Miranda S, Montgomery C, Agbodza E, Chauhan D, Houtrow A, Smith K, Foy AB, Leonard JR, Castillo H, Castillo J, Cady RG, Bowman RM, Freeman KA, Rocque BG, Flanders TM, and Heuer GG

Subjects
Humans, Male, Female, Adolescent, Young Adult, Child, United States epidemiology, Child, Preschool, Infant, Decompression, Surgical, Registries, Neurosurgical Procedures, Social Determinants of Health, Meningomyelocele surgery, Spinal Dysraphism surgery
Abstract

Objective: Myelomeningocele (MMC) is a lifelong condition requiring complex multidisciplinary management. Using the National Spina Bifida Patient Registry (NSBPR), the authors tested the association between sociodemographic variables and odds of undergoing neurosurgical procedures., Methods: The authors extracted sociodemographic, clinical, and neurosurgical procedure data on participants with MMC aged ≥ 1 year who visited an NSBPR clinic between 2009 and 2020. The zip code of the participant's residence at the time of the last spina bifida clinic visit was linked to the Distressed Communities Index (DCI) tier. Multivariate models were built to identify factors associated with undergoing CSF diversion, shunt revision, tethered cord release (TCR), and Chiari decompression., Results: There were 7924 participants with a median visit age of 13 years (IQR 7-20 years); 49.1% were male, 30.2% were non-Hispanic Black or Hispanic, 54.5% had public/supplemental insurance, and 16.9% were from distressed communities. CSF diversion, shunt revision, TCR, and Chiari decompression were performed in 81.8%, 47.7%, 22.9%, and 8.7% of participants, respectively. In multivariate analyses controlling for age, sex, insurance, DCI tier, lesion level, and surgical closure timing, Hispanic individuals were less likely than their non-Hispanic White counterparts to undergo shunt revision (p = 0.013). Non-Hispanic Black and Hispanic individuals were less likely to undergo TCR (p < 0.001 each) or Chiari decompression (p < 0.001 each). Compared with privately insured individuals, publicly insured individuals were more likely to undergo CSF diversion (p = 0.031). Those in distressed communities had increased odds of undergoing CSF diversion (p = 0.004) than those in prosperous communities., Conclusions: Among individuals with MMC participating in the NSBPR, there were differences in receiving neurosurgical procedures by race/ethnicity, insurance type, and DCI tier. Additional prospective studies are necessary to elucidate the reasons for these variations and their impact on long-term outcomes for this patient population in order to created targeted interventions.

Published
2024
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41. Comparing binary & ordinal definitions of urinary & stool continence outcomes: Data from the National Spina Bifida Patient Registry.

Author

Kelly MS, Liu T, Routh JC, Castillo H, Tanaka ST, Smith K, Krach LE, Zhang A, Sherburne E, Castillo J, David J, and Wiener JS

Subjects
Humans, Female, Male, Child, Adolescent, United States epidemiology, Child, Preschool, Young Adult, Adult, Fecal Incontinence epidemiology, Fecal Incontinence diagnosis, Fecal Incontinence etiology, Urinary Incontinence epidemiology, Urinary Incontinence diagnosis, Registries, Spinal Dysraphism complications
Abstract

Introduction: The National Spina Bifida Patient Registry (NSBPR) assesses bladder and bowel incontinence using ordinal categories, but prior NSBPR analyses employed binary classification. Our aims were to 1) perform the first NSBPR analysis of bladder and bowel incontinence as ordinal outcomes to compare to the binary definition and subject variables; 2) explore the correlation of incontinence with undergarment usage, and 3) assess incontinence status following continence surgeries., Methods: Data from NSBPR participants' most recent clinic visit from 2013 to 2020 were analyzed. Ordinal categories of incontinence were compared to previously used binary definitions. Incontinence surgical outcomes were analyzed for those with data at least three months post-operatively. Chi-square tests evaluated associations among categorical variables. Univariate and ordinal logistic regression models were used to test associations of ordinal incontinence status with patient and condition factors. Statistical tests were 2-sided; p values < 0.05 were considered significant., Results: Analysis of 7217 individuals using ordinal incontinence outcomes showed little difference from previously used binary outcomes. The final multivariable logistic regression models with ordinal multinomial outcomes showed that associations of incontinence with age, sex, race/ethnicity, health insurance, level of lesion, and continence management technique were similar to prior studies. Among those reporting never being incontinent of both bladder and bowel, 14% reported using protective undergarments. Of the 500 individuals who had bladder outlet surgery, 38% reported never being incontinent of urine. Of 1416 individuals who had appendicostomy (ACE) bowel surgery, 48% reported never being incontinent of stool., Discussion: Our current analysis showed that ordinal continence outcome classification had similar continence findings as previous studies using the binary definition of continence. Expanding the binary definition of continence to include monthly episodes of incontinence did not greatly increase the proportion of continent individuals and, therefore, would have not likely made meaningful differences in continence outcomes in prior NSBPR analyses. However, it is known that even mild incontinence can affect quality of life, therefore, capturing any level of incontiennce is of clinical importance. Confirmation of the association of continence outcomes with sociodemographic, condition-related, and interventional factors with both approaches further validates previous analyses using the binary definition of continence., Conclusion: The previously used binary definition of bladder and bowel continence appears robust. Undergarment choice was a poor surrogate for reported incontinence. After bladder and bowel continence surgeries, 38% and 48%, respectively, reported never being incontinent., Competing Interests: Conflict of interest MSK serves as advisor for Coloplast A/C, Humlebaek, Denmark., (Copyright © 2024 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)

Published
2024
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42. Impact of Synthesis Method on the Structure and Function of High Entropy Oxides.

Author

González-Rivas MU, Aamlid SS, Rutherford MR, Freese J, Sutarto R, Chen N, Villalobos-Portillo EE, Castillo-Michel H, Kim M, Takagi H, Green RJ, and Hallas AM

Abstract

The term sample dependence describes the troublesome tendency of nominally equivalent samples to exhibit different physical properties. High entropy oxides (HEOs) are a class of materials where sample dependence has the potential to be particularly profound due to their inherent chemical complexity. In this work, we prepare a spinel HEO of identical nominal composition by five distinct methods, spanning a range of thermodynamic and kinetic conditions: solid state, high pressure, hydrothermal, molten salt, and combustion syntheses. By structurally characterizing these five samples across all length scales with a variety of X-ray methods, we find that while the average structure is unaltered, the samples vary significantly in their local structures and their microstructures. The most profound differences are observed at intermediate length scales, both in terms of crystallite morphology and cation homogeneity. As revealed by X-ray fluorescence microscopy ideal cation homogeneity is achieved only in the case of combustion synthesis. These structural differences in turn significantly alter the observed functional properties, which we demonstrate via characterization of their magnetic response. While ferrimagnetic order is retained across all five samples, the sharpness of the transition, the size of the saturated moment, and the coercivity all show marked variations with synthesis method. We conclude that the chemical flexibility inherent to HEOs is complemented by strong synthesis method dependence, providing another axis along which to optimize these materials for a wide range of applications.

Published
2024
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43. PSAP-Genomic-Regions: A Method Leveraging Population Data to Prioritize Coding and Non-Coding Variants in Whole Genome Sequencing for Rare Disease Diagnosis.

Author

Ogloblinsky MC, Bocher O, Aloui C, Leutenegger AL, Ozisik O, Baudot A, Tournier-Lasserve E, Castillo-Madeen H, Lewinsohn D, Conrad DF, Génin E, and Marenne G

Abstract

The introduction of Next-Generation Sequencing technologies in the clinics has improved rare disease diagnosis. Nonetheless, for very heterogeneous or very rare diseases, more than half of cases still lack molecular diagnosis. Novel strategies are needed to prioritize variants within a single individual. The Population Sampling Probability (PSAP) method was developed to meet this aim but only for coding variants in exome data. Here, we propose an extension of the PSAP method to the non-coding genome called PSAP-genomic-regions. In this extension, instead of considering genes as testing units (PSAP-genes strategy), we use genomic regions defined over the whole genome that pinpoint potential functional constraints. We conceived an evaluation protocol for our method using artificially generated disease exomes and genomes, by inserting coding and non-coding pathogenic ClinVar variants in large data sets of exomes and genomes from the general population. PSAP-genomic-regions significantly improves the ranking of these variants compared to using a pathogenicity score alone. Using PSAP-genomic-regions, more than 50% of non-coding ClinVar variants were among the top 10 variants of the genome. On real sequencing data from six patients with Cerebral Small Vessel Disease and nine patients with male infertility, all causal variants were ranked in the top 100 variants with PSAP-genomic-regions. By revisiting the testing units used in the PSAP method to include non-coding variants, we have developed PSAP-genomic-regions, an efficient whole-genome prioritization tool which offers promising results for the diagnosis of unresolved rare diseases., (© 2024 Wiley Periodicals LLC.)

Published
2024
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44. Scabies, Bedbug, and Body Lice Infestations: A Review.

Author

Thomas C, Castillo Valladares H, Berger TG, and Chang AY

Abstract

Importance: Scabies, bedbug, and body lice infestations are caused by organisms that live on or in the skin, on clothing, or in the environment and commonly cause pruritus and rash. In 2021, approximately 622 million incident cases of scabies occurred globally. Data on bedbug infestations are limited. Body lice prevalence ranges from 4.1% to 35% among persons experiencing homelessness worldwide., Observations: Scabies is caused by mites (Sarcoptes scabiei) that burrow into the epidermis. Transmission primarily occurs from prolonged skin-to-skin contact with an individual who has an infestation. Common scabies is characterized by excoriated pruritic papules, plaques, and pathognomonic burrows on finger/toe web spaces, volar wrists, ankles, axillae, buttocks, male genitalia, and areolae. Permethrin cream and oral ivermectin are first-line treatments for adults, with similar clearance rates by week 2 (74% with permethrin vs 68% with ivermectin; relative risk, 0.91; 95% CI, 0.76-1.08). Treatment failure can occur with oral ivermectin (11.8%; 95% CI, 8.4%-15.4%) and topical permethrin (10.8%; 95% CI, 7.5%-14.5%). Bedbugs (Cimex lectularius, Cimex hemipterus) are insects that live on mattresses and furniture and feed on blood nocturnally, causing linear pruritic erythematous papules. New skin lesions on waking, cohabitants with similar symptoms, and recently residing in a high-occupancy setting should raise suspicion. Treatment requires eradication with pest management. Body lice (Pediculus humanus humanus) are insects found on clothing that travel to the skin for blood meals. Body lice bites cause pruritic excoriated macules/papules and hyperpigmentation in areas where clothing seams contact skin. Treatment and prevention require at least once-weekly bathing and laundering of clothing and bedding., Conclusions and Relevance: Scabies, bedbug, and body lice infestations are common. Accurate diagnosis requires taking a history, including social drivers of health (eg, housing status, living environment), and physical examination. First-line treatments include scabicides for patients with common scabies and their close contacts. Scabies, bedbug, and body lice infestations should be treated with decontamination measures.

Published
2024
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45. Top DEI Topics to Incorporate Into Dermatology Residency Training: An Electronic Delphi Consensus Study.

Author

Encarnación-Cortés VS, Rodriguez I, Rinderknecht FA, Admassu N, Phillips G, Castillo-Valladares H, Tarbox M, Peebles JK, Stratman EJ, Altman EM, Pimentel MA, Elbuluk N, Parekh P, Daveluy S, James W, Kim SJ, Rosmarin D, Kakpovbia E, Silverberg JI, Bowers S, Vasquez R, Worswick SD, and Ahmed AM

Subjects
Humans, Cultural Diversity, Surveys and Questionnaires, Dermatology education, Internship and Residency, Delphi Technique, Curriculum, Consensus
Abstract

Current dermatology residency education may be deficient in curricular topics and training related to diversity, equity, and inclusion (DEI). Integrating more DEI topics within residency curricula may improve clinical care delivered to diverse populations and improve cultural humility among trainees. The objective of this electronic Delphi (e-Delphi) study was to reach a consensus on the most important DEI topics for inclusion in dermatology residency program curricula nationwide. Sixty-one DEI-related topics were proposed by an expert panel consisting of dermatologists from the Association of Professors of Dermatology DEI subcommittee and the American Academy of Dermatology Diversity Task Force. Two rounds of anonymous electronic surveys based on a 5-point Likert scale were administered using a modified e-Delphi design. Voluntary participants including residents and academic dermatologists were self-selected after an email was sent to the Association of Professors of Dermatology listserve.

Published
2024
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46. Xenopus tropicalis osteoblast-specific open chromatin regions reveal promoters and enhancers involved in human skeletal phenotypes and shed light on early vertebrate evolution.

Author

Castillo H, Hanna P, Sachs LM, Buisine N, Godoy F, Gilbert C, Aguilera F, Muñoz D, Boisvert C, Debiais-Thibaud M, Wan J, Spicuglia S, and Marcellini S

Subjects
Animals, Humans, Biological Evolution, Vertebrates genetics, Bone and Bones metabolism, Osteogenesis genetics, Osteoblasts metabolism, Promoter Regions, Genetic genetics, Phenotype, Xenopus genetics, Enhancer Elements, Genetic genetics, Chromatin metabolism, Chromatin genetics
Abstract

While understanding the genetic underpinnings of osteogenesis has far-reaching implications for skeletal diseases and evolution, a comprehensive characterization of the osteoblastic regulatory landscape in non-mammalian vertebrates is still lacking. Here, we compared the ATAC-Seq profile of Xenopus tropicalis (Xt) osteoblasts to a variety of non mineralizing control tissues, and identified osteoblast-specific nucleosome free regions (NFRs) at 527 promoters and 6747 distal regions. Sequence analyses, Gene Ontology, RNA-Seq and ChIP-Seq against four key histone marks confirmed that the distal regions correspond to bona fide osteogenic transcriptional enhancers exhibiting a shared regulatory logic with mammals. We report 425 regulatory regions conserved with human and globally associated to skeletogenic genes. Of these, 35 regions have been shown to impact human skeletal phenotypes by GWAS, including one trps1 enhancer and the runx2 promoter, two genes which are respectively involved in trichorhinophalangeal syndrome type I and cleidocranial dysplasia. Intriguingly, 60 osteoblastic NFRs also align to the genome of the elephant shark, a species lacking osteoblasts and bone tissue. To tackle this paradox, we chose to focus on dlx5 because its conserved promoter, known to integrate regulatory inputs during mammalian osteogenesis, harbours an osteoblast-specific NFR in both frog and human. Hence, we show that dlx5 is expressed in Xt and elephant shark odontoblasts, supporting a common cellular and genetic origin of bone and dentine. Taken together, our work (i) unravels the Xt osteogenic regulatory landscape, (ii) illustrates how cross-species comparisons harvest data relevant to human biology and (iii) reveals that a set of genes including bnc2, dlx5, ebf3, mir199a, nfia, runx2 and zfhx4 drove the development of a primitive form of mineralized skeletal tissue deep in the vertebrate lineage., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Published
2024
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47. A retrospective cross-sectional analysis of gender and racial/ethnic diversity trends in dermatology chairs.

Author

Williams JC, Castillo Valladares H, Waul MA, Mathes E, Pandya AG, and Amerson EH

Subjects
Female, Humans, Male, Cross-Sectional Studies, Cultural Diversity, Ethnicity statistics & numerical data, Faculty, Medical statistics & numerical data, Faculty, Medical trends, Racial Groups statistics & numerical data, Retrospective Studies, Sex Factors, United States, Dermatology statistics & numerical data, Dermatology trends
Abstract

Competing Interests: Conflicts of interest Dr Mathes reports personal fees from UpToDate as an author and reviewer, Elsevier as an author and editor, and Pierre Fabre, Rodan + Fields, and Aldeyra Therapeutics as a consultant. Author Pandya declares consultancy fees from AbbVie, Arcutis, Avita, Immune Tolerance Network, Incyte, Pfizer, Thalocan, WCG/Trifecta, Twi, Villaris, Vimela, and Vyne and holds stock options with Tara Medical and Zerigo Health. Drs Williams, Valladares, Waul, and Amerson have no conflicts to disclose.

Published
2024
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48. Psychometric Evaluation of the Brief-COPE Inventory and Exploration of Factors Associated with Perceived Stress among Peruvian Nurses.

Author

Zeladita-Huaman JA, Flores-Rodríguez CC, Zegarra-Chapoñan R, Carpio-Borja SJ, Franco-Chalco E, Vivas-Durand TJ, Castillo-Parra H, Alvarado-Rivadeneyra SH, and Mariñas-Acevedo O

Abstract

Background: This study aimed to analyze the psychometric properties of the Brief-COPE Inventory and to determine its concurrent validity by examining its association with perceived stress among Peruvian nurses., Methods: A psychometric study was conducted with 434 Peruvian nurses to evaluate the psychometric properties of the Brief-COPE Inventory through confirmatory factor analysis. Three stepwise variable selection regression models were implemented., Results: The three-factor model of the Brief-COPE Inventory demonstrated adequate fit indices (root mean square error of approximation = 0.052, standardized root mean square residual = 0.068, and both the comparative fit index and the Tucker-Lewis index = 0.95). Additionally, the factors were significantly correlated ( p < 0.001), and the reliability was adequate (ω = 0.90). Nurses reported a medium level of perceived stress, with associated factors including having received stress management training, fear of COVID-19, and problem-focused coping strategies ( p < 0.05)., Conclusion: This study confirms that the Brief-COPE Inventory is a valid tool for measuring coping strategies among Peruvian nurses due to its good model fit, excellent reliability, and concurrent validity with perceived stress. However, further research is needed to assess its validity in the specific areas of performance perceived by nursing professionals.

Published
2024
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49. Surgical Management and Its Impact on Adjuvant Treatment in Recurrent Ipsilateral Breast Cancer: A Retrospective Cohort Study.

Author

Torras I, Cebrecos I, Castillo H, Rodríguez L, Zaragoza-Ballester P, Sitges C, Loinaz I, Garcia M, Molla M, Vidal-Sicart S, and Mension E

Abstract

Background: Breast cancer (BC) recurrence, defined as the reappearance of cancer in the ipsilateral breast after primary treatment, poses significant challenges in clinical management. Despite advances in treatment, recurrence rates persist, ranging from 0.6 to 1.5% annually, reaching 10-15% at 20 years. This study aims to analyze the surgical and oncological characteristics of patients with BC recurrence. Methods: This retrospective study includes 56 patients diagnosed with recurrent BC between October 2018 and April 2022. Data were collected from a prospectively maintained surgical database. A descriptive analysis was performed on the initial BC, and the recurrence, including surgical complications, was classified using the Clavien-Dindo system. The success rates of selective sentinel lymph node (SLN) biopsies and aberrant drainages were assessed based on previous surgeries. Results : The cohort included 55 females and 1 male, with a median age of 65.3 years. The mean time to BC recurrence was 11.5 years. Among them, 26.8% underwent breast-conserving surgery, 41.1% had a mastectomy, 21.4% had a mastectomy with reconstruction, and 10.7% had an excision over a previous mastectomy. An SLN biopsy was performed in 78.6% of cases, with higher success rates in those without a previous axillary lymph node dissection (85.7% vs. 63.2%). Aberrant drainage was more frequent in patients with a previous ALND (44.4% vs. 20%). The median follow-up was 41.3 months, with 10.7% experiencing a second recurrence. Conclusions: Repeat breast-conserving surgery with re-irradiation for ipsilateral recurrence is feasible and does not significantly increase complications. SLN biopsy is valuable for restaging and tailoring adjuvant therapies, with ALND not being necessary if re-SLN biopsy shows no drainage. The management of aberrant drainage remains controversial., Competing Interests: The authors declare no conflicts of interest.

Published
2024
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50. Analysis of a newly developed multidisciplinary program in the Middle East informed by the recently revised spina bifida guidelines.

Author

Collier T, Castillo J, Thornton L, Vallasciani S, and Castillo H

Abstract

Purpose: This paper describes the development and characteristics of a multi-disciplinary spina bifida clinic in Qatar considering the recently revised and globally available Guidelines for the Care of People with Spina Bifida (GCPSB)., Methods: A retrospective chart review was performed on individuals in Sidra's multidisciplinary spina bifida clinic database from January 2019 to June 2020. Their electronic health records were reviewed for demographics, as well as neurosurgical, urologic, rehabilitation, and orthopedic interventions., Results: There were 127 patients in the database; 117 met inclusion criteria for diagnoses of myelomeningocele, meningocele, sacral agenesis/caudal regression, and/or spinal lipoma. Generally, Qatar is following GCPSB recommendations for multidisciplinary care. Consanguineous relationships, difficulties with access to urological and rehabilitation supplies and equipment, school access, and variable timing of neurosurgical closure were areas that demonstrated differences from GCPSB recommendations due to barriers in implementation., Conclusion: The GCPSB recommendations are applicable in an international setting such as Qatar. Despite a few barriers in implementing some of the recommendations, this new multi-disciplinary spina bifida clinic demonstrates alignment with many of the GCPSB guidelines.

Published
2024
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