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The European Sentinel missions and the latest generation of the United States Landsat satellites provide new opportunities for global environmental monitoring. They acquire imagery at spatial resolutions between 10 and 60 m in a temporal and spatial coverage that could before only be realized on the basis of lower resolution Earth observation data ( $ > $ 250 m). However, images gathered by these modern missions rapidly add up to data volume that can no longer be handled with standard work stations and software solutions. Hence, this contribution introduces the TimeScan concept which combines pre-existing tools to an exemplary modular pipeline for the flexible and scalable processing of massive image data collections on a variety of (private or public) computing clusters. The TimeScan framework covers solutions for data access to arbitrary mission archives (with different data provisioning policies) and data ingestion into a processing environment (EO2Data module), mission specific pre-processing of multi-temporal data collections (Data2TimeS module), and the generation of a final TimeScan baseline product (TimeS2Stats module) providing a spectrally and temporally harmonized representation of the observed surfaces. Technically, a TimeScan layer aggregates the information content of hundreds or thousands of single images available for the area and time period of interest (i.e. up to hundreds of TBs or even PBs of data) into a higher level product with significantly reduced volume. In first test, the TimeScan pipeline has been used to process a global coverage of 452,799 multispectral Landsat–8 scenes acquired from 2013 to 2015, a global data-set of 25,550 Envisat ASAR radar images collected 2010–2012, and regional Sentinel–1 and Sentinel–2 collections of $ \sim $ 1500 images acquired from 2014 to 2016. The resulting TimeScan products have already been successfully used in various studies related to the large-scale monitoring of environmental processes and their temporal dynamics.

The Sentinel fleet will provide a so-far unique coverage with Earth observation data and therewith new opportunities for the implementation of methodologies to generate innovative geo-information products and services. It is here where the TEP Urban project is supposed to initiate a step change by providing an open and participatory platform based on modern ICT technologies and services that enables any interested user to easily exploit Earth observation data pools, in particular those of the Sentinel missions, and derive thematic information on the status and development of the built environment from these data. Key component of TEP Urban project is the implementation of a web-based platform employing distributed high-level computing infrastructures and providing key functionalities for i) high-performance access to satellite imagery and derived thematic data, ii) modular and generic state-of-the art pre-processing, analysis, and visualization techniques, iii) customized development and dissemination of algorithms, products and services, and iv) networking and communication. This contribution introduces the main facts about the TEP Urban project, including a description of the general objectives, the platform systems design and functionalities, and the preliminary portfolio products and services available at the TEP Urban platform.

The Henoch-Schönlein-syndrome, or anaphylactoid purpura, is usually a childhood disease. The progess of this syndrome in adults was observed in 4 cases at our clinic. An elevated IgA level in the serum with a normal complement value seems to be of immunological interest. By immunohistological methods fibrin and IgA could be demonstrated in skin and kidney biopsies; in glomerulae C3c was observed, occasionally accompanied by Properdin-factor-B. These findings differentiate this disease from other allergic superficial vasculitids by the detection of IgG and complement; while at the same time some similarities are indicated to the so called "Berger Nephritis" with comparable kidney findings.

On blood lymph nodes and spleen cells of 4 patients with leukemic reticuloendotheliosis (LR) the binding of 125-J-labelled IgG aggregates as well as binding of 125J-labeled anti immunoglobulin sera was studied. Moreover the capacity to form spontaneous rosettes with sheep red blood cells to bind immune complement complexes as well as the proliferative response in the presence of PHA were investigated. On the surface of hairy cells a variety of immunoglobulins were demonstrable. IgG of both types was found to be the predominant surface bound immunoglobulin and evidence was obtained, that these antibodies were adsorbed from the serum via Fc-receptors. In all LR-cases the percentages of T-cell rosettes as well as the PHA responses were decreased when compared with the normal controls. The numbers of immune complement complex binding cells were in the range of the normal controls. Results are discussed with respect to the origin of hairy cells in LR.