1. Relation between detection rate and inappropriate shocks in single versus dual chamber cardioverter-defibrillator – an analysis from the OPTION trial
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Peter Sick, Verena Semmler, Jean Marc Davy, Carsten Lennerz, Giuseppe Mantovani, Giulio Molon, Sebastian Reif, Christof Kolb, Pierre-Henri Siot, Dominique Babuty, M. Sturmer, J.O. Schwab, Andrew Wickliffe, Technical University of Munich (TUM), Université de Montréal - UdeM (CANADA), Université de Montréal (UdeM), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Tours, University Hospital Regensburg, Hospital of the Order of St. John of God, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Sacro Cuore, Negrar, Bonn University Hospital, Hôpital Civile, Desio, Piedmont Heart Institute (PHI - ATLANTA), PIEDMONT HEART INSTITUTE, Sorin CRM SAS, Universität Regensburg (UR), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Tours (UT), and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) more...
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Male ,medicine.medical_specialty ,Pediatrics ,[SDV]Life Sciences [q-bio] ,Population ,Electric Countershock ,030204 cardiovascular system & hematology ,Ventricular tachycardia ,Article ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,education ,Aged ,Inappropriate shock ,education.field_of_study ,Multidisciplinary ,business.industry ,Middle Aged ,medicine.disease ,3. Good health ,Defibrillators, Implantable ,ddc ,Death, Sudden, Cardiac ,Treatment Outcome ,Ventricular fibrillation ,Cardiology ,Tachycardia, Ventricular ,Female ,Detection rate ,business ,Algorithms ,Software ,Single chamber - Abstract
The programming of implantable cardioverter-defibrillators (ICDs) influences inappropriate shock rates. The aim of the study is to analyse rates of patients with appropriate and inappropriate shocks according to detection zones in the OPTION trial. All patients received dual chamber (DC) ICDs randomly assigned to be programmed either to single chamber (SC) or to DC settings including PARAD+ algorithm. In a post-hoc analysis, rates of patients with inappropriate and appropriate shocks were calculated for shocks triggered at heart rates ≥170 bpm (ventricular tachycardia zone) and at rates ≥200 bpm (ventricular fibrillation zone). In the SC group, higher rates of patients with total and inappropriate shocks were delivered at heart rates ≥170 bpm than at rates ≥200 bpm (total shocks: 21.1% vs. 16.6%; p = 0.002; inappropriate shocks: 7.6% vs. 4.5%, p = 0.016; appropriate shocks: 15.2% vs. 13.5%; p = n.s.). No such differences were observed in the DC group (total shocks: 14.3% vs. 12.6%; p = n.s.; inappropriate shocks: 3.9% vs. 3.6%; p = n.s.; appropriate shocks: 12.2% vs. 10.4%; p = n.s.). The higher frequency of patients with total shocks with SC settings than with DC settings that benefit from PARAD+ was driven by a higher percentage of patients with inappropriate shocks in the VT zone (170–200 bpm) in the SC population. more...
- Published
- 2016
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