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1. Etelcalcetide use During Maintenance Hemodialysis and Incidence of Parathyroidectomy After Kidney Transplantation

Author

Decleire, Pierre-Yves, Rommelaere, Marie, Guillen, Miguel-Ange, Buysschaert, Benoit, Vanderperren, Bénédicte, Cuvelier, Charles, Georges, Benoît, Papakrivopoulou, Eugenia, Braun, Claude, Gillerot, Gaëlle, Lengelé, Jean-Philippe, Reginster, François, Leroy, Philippe, Vandooren, Ann-Karolien, Madhoun, Philippe, Delaey, Philippe, Devresse, Arnaud, Morelle, Johann, Faitatzidou, Danai, Iriarte, Miren, Kanaan, Nada, Buemi, Antoine, Mourad, Michel, Darius, Tom, Goffin, Eric, Jadoul, Michel, and Labriola, Laura

Published
2024
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3. Clinical and Epidemiological Correlates of Low IFN-Gamma Responses in Mitogen Tube of QuantiFERON Assay in Tuberculosis Infection Screening During the COVID-19 Pandemic: A Population-Based Marker of COVID-19 Mortality?

Author

Palacios-Gutiérrez, Juan-José, Rodríguez-Guardado, Azucena, Arias-Guillén, Miguel, Alonso-Arias, Rebeca, Palacios-Penedo, Sergio, García-García, José-María, Balbín, Milagros, Pérez-Hernández, Dolores, Sandoval-Torrientes, Marta, Torreblanca-Gil, Aurora, Melón, Santiago, Asensi-Álvarez, Víctor, Clain, Jeremy M., and Escalante, Patricio

Published
2022
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4. Clinical impact of a pleural unit in a tertiary level hospital

Author

Enríquez Rodríguez, Ana Isabel, García Clemente, Marta, Ruíz Álvarez, Inés, Hermida Valverde, Tamara, Herrero Huertas, Julia, Arias Guillén, Miguel, Madrid Carbajal, Claudia Janeth, García Alfonso, Lucía, Ortiz Reyes, Andres Mauricio, Moreda Bernardo, Ariel, Pérez Martínez, Liliana, Casán Clará, Pere, and López González, Francisco Julián

Published
2020
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6. Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial

Author

Amado-Rodríguez, Laura, Del Busto, Cecilia, López-Alonso, Inés, Parra, Diego, Mayordomo-Colunga, Juan, Arias-Guillén, Miguel, Albillos-Almaraz, Rodrigo, Martín-Vicente, Paula, López-Martínez, Cecilia, Huidobro, Covadonga, Camporota, Luigi, Slutsky, Arthur S., and Albaiceta, Guillermo M.

Published
2021
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7. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author

Yañez, Anahí, Fernández, Marcelo, Tolcachier, Alberto, Belloni, Juan, Taborda, Jorge, De Salvo, Maria, Maspero, Jorge, Victorio, Carlos, Navarta, Miguel Chirino, Grilli, Monica, Rodríguez, Pablo, Otaola, María, Cambursano, Víctor, Malamud, Patricia, Stok, Ana, Arce, German, Roza, Osiris, Scherbovsky, Fernando, Elias, Pedro, Saez, Maria Salazan, Peters, Matthew, Phillips, Martin, Upham, John, Gibson, Peter, Thien, Francis, Douglass, Jo, Thomas, Paul, Bardin, Philip, Sajkov, Dimitar, Hew, Mark, Langton, David, Pez, Andreia, Fritscher, Carlos, Hetzel, Jorge, Mattos, Waldo, Stelmach, Rafael, Antila, Martti, Fernandes, Ana Luisa, Metev, Hristo, Ivanov, Yavor, Bogdanova, Aneliya, Markova, Ana Dancheva, Peneva, Marinka, Veselinova, Rumyana, Petkova, Tatyana, Petrova, Vanushka, Shopova, Elena, Ivanova, Yuliya, Yotsova, Rumyana, Kirkova, Ginka, Petrova, Galina, Dachev, Svetoslav, Sotirova, Kostadinka, Stoyanova, Mariyana, Yakov, Oleg, Ilieva-Fartunova, Vanya, Lemiere, Catherine, Laviolette, Michel, Yang, William, FitzGerald, J Mark, Pek, Bonavuth, Killorn, William Patrick, Poirier, Claude, Chouinard, Guy, Melenka, Lyle, Leigh, Richard, Nair, Parameswaran, Dorscheid, Delbert, Martin, James, Pavie, Juana, Rosenblut, Andres, Cartagena, Claudia, Quilodran, Carlos, Muñoz, Silvia, Malkusova, Ivana, Veverka, Josef, Holub, Stanislav, Mares, Jaroslav, Kozel, Radovan, Kopecka, Daniela, Zindr, Vladimir, Cerva, Pavel, Chanez, Pascal, Bourdin, Arnaud, Devouassoux, Gilles, Taille, Camille, De Blay, Frédéric, Goupil, Francois, Leroyer, Christophe, Gourcerol, Delphine, Didi, Toufik, Didier, Alain, Garcia, Gilles, Bonniaud, Philippe, Vasram, Riazate Rossanaly, Lommatzsch, Marek, Harnest, Ulf, Linnhoff, Anneliese, Keller, Claus, Hoheisel, Gerhard, Förster, Karin, Schultz, Thomas, Schenkenberger, Isabelle, Kirschner, Joachim, Schmoller, Tibor, Zielen, Stefan, Kornmann, Marc, Beck, Ekkehard, Volgmann, Lutz, Dichmann, Rolf, Overlack, Axel, Winkler, Jörg, Mikloweit, Petra, Ballenberger, Sabine, Rolke, Mathias, Korn, Stephanie, Pabel, Helmut, Hoffmann, Martin, Feimer, Jan, Rabe, Klaus, Deckelmann, Regina, Welte, Tobias, Ohbayashi, Hiroyuki, Hozawa, Soichiro, Shimoda, Terufumi, Yoshida, Makoto, Nagakura, Toshikazu, Kamei, Tadashi, Sano, Yasuyuki, Kagami, Shinichiro, Takahashi, Hisaho, Haida, Michiko, Kimura, Goro, Nakamura, Hiroyuki, To, Yasuo, Shinkai, Masaharu, Shimokawaji, Tadasuke, Kudo, Makoto, Shijyubo, Noriharu, Tochigi, Takao, Kato, Motokazu, Tanaka, Akihiko, Gon, Yasuhiro, Sasaki, Norihisa, Ohdaira, Tetsuro, Omori, Chiharu, Takahashi, Toshiki, Takeuchi, Satomi, Nakajima, Kiyotaka, Makita, Hironi, Kaneko, Masahiro, Furuta, Kenjiro, Taniguchi, Masami, Inobe, Yoshito, Miki, Hiroshi, Nakamura, Yoichi, Miyazawa, Naoki, Yano, Shuichi, Iijima, Masayuki, Yamato, Tsuyoshi, Diaz, Javier, Matsuno, Alberto, Felix, Efrain, Guerreros, Alfredo, Daly, Alejandro, Rodriguez Chariarse, Fernando, Salazar, Danilo, Castro, Socorro, Chavez, William, Estrella, Rolando, Aquino, Teresita, Atienza, Tito, Samoro, Ronnie, Isidro, Marie Grace Dawn, Kuna, Piotr, Antczak, Adam, Bednarek, Michał, Mądra-Rogacka, Danuta, Hofman, Teresa, Jutel, Marek, Pisarczyk-Bogacka, Ewa, Kot, Agata, Mróz, Robert, Czupryńska-Borkowska, Małgorzata, Żurowska-Gębala, Małgorzata, Dyczek, Andrzej, Jasieniak-Pinis, Grażyna, Wojnowski, Piotr, Trębas-Pietraś, Ewa, Dobryniewska, Małgorzata, Stobiecki, Marcin, Tarnowska-Matusiak, Marzenna, Magner, Alina, Kolczyński, Andrzej, Kachel, Tomasz, Bartuzi, Zbigniew, Majorek-Olechowska, Bernadetta, Śliwiński, Paweł, Balicka, Violetta, Hajoł, Elżbieta, Stachera, Jacek, Rachel, Marta, Michnar, Marek, Tałałaj, Jarosław, Springer, Ewa, Napora, Piotr, Grzelewski, Tomasz, Bijata-Bronisz, Renata, Świderska, Anna, Mincewicz, Grzegorz, Sankowski, Zbigniew, Fijołek, Tomasz, Kwaśniewski, Artur, Jerzyńska, Joanna, Cygler, Jerzy, Olesiejuk, Ryszard, Von Steiner, Iwona, Machowiak, Wojciech, Filipek, Krzysztof, Piskorz, Piotr, Uhryn, Ewa, Nittner-Marszalska, Marita, Rybicka-Liszewska, Elżbieta, Bodzenta-Łukaszyk, Anna, Chełmińska, Marta, Krupa-Borek, Izabella, Skucha, Wojciech, Płoszczuk, Anna, Mihaescu, Traian, Petrui, Ioan Dorin, Savu, Angelica, Apti, Ghiulten, Toma, Claudia, Trailescu, Ana, Sokurenko, Sergei, Trofimov, Vasiliy, Leshchenko, Igor, Shaporova, Natalia, Ilyashevich, Inna, Stitsenko, Irina, Vizel, Alexander, Ilkovich, Yulia, Tikhanov, Dmitrii, Goncharova, Svetlana, Ezhov, Andrey, Ignatova, Galina, Izmozherova, Nadezhda, Berdnikova, Nadezhda, Goryachkina, Ludmila, Popova, Veronika, Bolieva, Laura, Rebrov, Andrey, Nosov, Vladimir, Magnitskaya, Olga, Nedogoda, Sergey, Abrosimov, Vladimir, Molotkov, Artem, Reshedko, Galina, Smirnov, Mikhail, Osipenko, Marina, Pavlysh, Elena, Myasoedova, Svetlana, Lenskaya, Liudmila, Chistyakov, Valery, Vishneva, Elena, Uon, Liliya, Zateyschikova, Anna, Laleko, Svetlana, Pak, Tatiana, Bruning, Axel, Naidoo, Visvakuren, Reddy, Jeevren, Van Zyl Smit, Richard, Park, Hae-Sim, Cho, Young Joo, Cho, Sang-Heon, Lee, Sang Haak, Lee, Byung Jae, Kim, Ju Sang, Cho, You Sook, Park, Choon-Sik, Kim, Mi-Kyeong, Koh, Young-Il, Kim, Joo-Hee, Lee, Sook Young, Lee, Sang Pyo, Park, Jung Won, Yoo, Kwang Ha, Yoon, Hyoungkyu, Lee, Jaechun, Hur, Gyu-Young, Lee, Soo Keol, Kim, HeeKyoo, Ramos Barbón, David, Laffond Yges, Elena, Martínez Moragón, Eva, Arias Guillen, Miguel, Saura Vinuesa, Alberto, Sánchez-Toril López, Fernando, Velasco Garrido, José Luis, García-Cosio Piqueras, Borja, Pérez de Llano, Luis, Valero Santiago, Antonio Luis, Rubio, Myriam Calle, Bjermer, Leif, Lundbäck, Bo, Gemicioglu, Bilun, Bavbek, Sevim, Ediger, Dane, Erdinc, Munevver, Hanta, Ismail, Nayci, Sibel, Arinc, Sibel, Iashyna, Liudmyla, Mostovoy, Yuriy, Ostrovskyy, Mykola, Kuryk, Lesia, Lemko, Ivan, Ospanova, Tetyana, Moskalenko, Liubov, Korzh, Oleksii, Blazhko, Viktor, Krakhmalova, Olena, Romaniuk, Liliia, Dytyatkovs'ka, Yevgeniya, Yakovenko, Oleh, Gavrysyuk, Volodymyr, Burhan, Hassan, Saralaya, Dinesh, Scott, Stephen, Morice, Alyn, Jackson-Voyzey, Ewart, Win, Thida, Nasser, Shuab, Harrison, Richard, Chaudhuri, Rekha, Nordstrom, Monica, De, Pradip, Masoli, Matthew, Mansur, Adel, Gunstone, Anthony, Niven, Robert, Harrison, Timothy, Babu, Suresh, Bhuchar, Subodh, Kureishy, Shahrukh, Zwetchkenbaum, John, Kaplan, Lawrence, Bleecker, Eugene, Reyes, Santiago, Fakih, Faisal, Heuer, Marvin, Klein, Ryan, Marcus, Michael, Hussain, Iftikhar, Tanus, Tonny, Raissy, Hengameh, Alpizar, Sady, Rodriguez, Hector, Gleich, Gerald, Bridges, Tracy, Pouzar, Joe, Steven, Gary, Matz, Jonathan, Krstevska, Shana, Ziworitin, Dama, Kaplan, Adolfo, Sublett, James, DeAngelo, James, Darter, Amy, Agaiby, John, Hagan, John, Davis, Enrique, Siri, Dareen, Mcevoy, Charlene, Dharma, Chrisette, Karimjee, Najmuddin, Kelsen, Steven, Frade, Manuel, Silverthorn, Amy, Kline, Joel, Averill, Francis, Ruiz, Jose, Robinette, Emory, Shaikh, Zeeshan, Aguilar, Carlos, Nish, William, Alvarez, German, Ismail, Younus, Parikh, Purvi, Leong, Mila, Murphy, Dennis, Garcia, Francisco, Goldsobel, Alan, Blanco, Antonio, Campbell, Edward, Perez, Guido, Chupp, Geoffrey, Bates, Toby, Perez, Vandely, Wenzel, Sally, Shenoy, Kartik, Katial, Rohit, Bernstein, David, Parikh, Neil, Sims, William, Ferguson, Gary, Pham, David, George, Anu, Beasley, Richard, Perez, Gilberto, Garver, Robert, Garcia-Portela, Miriam, Wong, Stephen, Soong, Weily, Guillot, Richard, Hudes, Golda, Arif, Ahmed, Binker, Josefa, Villareal, Manuel, Ziegner, Ulrike, Ojile, Joseph, Goswami, Sanjeev, Piniella, Carlos, Segal, Ilia, Zafra, Heidi, Lee, Mitchell, Tarpay, Martha, Panuto, John, Merchant, Rajan, Springsteen, Peter, Scialla, Timothy, Shapero, Paul, Allen, Karen, Moss, Mark, Cruz, Humberto, Rumbyrt, Jeffrey, Boyd, Amy, Nathan, Robert, Bernstein, Jonathan, Jacobs, Joshua, Ginchansky, Elliot, Johnston, Janice, Baxter, Barbara, Johnson II, Thomas, Apaliski, Stephen, Corder, Clinton, Fuentes, David, Diaz, Joseph, Ngo, Chau, Le, Lan, Busse, William W, Bleecker, Eugene R, Ferguson, Gary T, Barker, Peter, Sproule, Stephanie, Olsson, Richard F, Martin, Ubaldo J, and Goldman, Mitchell

Published
2019
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11. Surveillance of adverse events in the treatment of drug-resistant tuberculosis: A global feasibility study

Author

Akkerman, Onno, Aleksa, Alena, Alffenaar, Jan-Willem, Al-Marzouqi, Nada Hassan, Arias-Guillén, Miguel, Belilovski, Evgeny, Bernal, Enrique, Boeree, Martin J., Borisov, Sergey E., Bruchfeld, Judith, Cadiñanos Loidi, Julen, Cai, Qingshan, Caminero, Jose A., Cebrian Gallardo, Jose Joaquín, Centis, Rosella, Codecasa, Luigi Ruffo, D’Ambrosio, Lia, Dalcolmo, Margareth, Danila, Edvardas, Dara, Masoud, Davidavičienė, Edita, Davies Forsman, Lina, De Los Rios Jefe, Jorge, Denholm, Justin, Duarte, Raquel, Elamin, Seifeldin Eltaeb, Ferrarese, Maurizio, Filippov, Alexey, Ganatra, Shashank, Garcia, Ana, García-García, José-María, Gayoso, Regina, Giraldo Montoya, Angela Maria, Gomez Rosso, Roscio Gomez, Gualano, Gina, Hoefsloot, Wouter, Ilievska-Poposka, Biljana, Jonsson, Jerker, Khimova, Elena, Kuksa, Liga, Kunst, Heinke, Laniado-Laborín, Rafael, Li, Yang, Magis-Escurra, Cecile, Manfrin, Vinicio, Manga, Selene, Marchese, Valentina, Martínez Robles, Elena, Maryandyshev, Andrei, Matteelli, Alberto, Migliori, Giovanni Battista, Mullerpattan, Jai B., Munoz-Torrico, Marcela, Mustafa Hamdan, Hamdan, Nieto Marcos, Magnolia, Noordin, Noorliza Mohamad, Palmero, Domingo Juan, Palmieri, Fabrizio, Payen, Marie-Christine, Piubello, Alberto, Pontali, Emanuele, Pontarelli, Agostina, Quirós, Sarai, Rendon, Adrian, Skrahina, Alena, Šmite, Agnese, Solovic, Ivan, Sotgiu, Giovanni, Souleymane, Mahamadou Bassirou, Spanevello, Antonio, Stošić, Maja, Tadolini, Marina, Tiberi, Simon, Udwadia, Zarir Farokh, van den Boom, Martin, Vescovo, Marisa, Viggiani, Pietro, Visca, Dina, Zhurkin, Dmitry, and Zignol, Matteo

Published
2019
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12. Assessment of risk scores in Covid‐19.

Author

García Clemente, Marta María, Herrero Huertas, Julia, Fernández Fernández, Alejandro, De La Escosura Muñoz, Covadonga, Enríquez Rodríguez, Ana Isabel, Pérez Martínez, Liliana, Gómez Mañas, Santiago, Iscar Urrutia, Marta, López González, Francisco Julián, Madrid Carbajal, Claudia Janeth, Bedate Díaz, Pedro, Arias Guillén, Miguel, Bailón Cuadrado, Cristina, and Hermida Valverde, Tamara

Abstract

Objective: To analyse the accuracy of commonly used risk scores (PSI and CURB‐65) in predicting mortality and need for ICU admission in Covid‐19. Material and methods: Prospective study of patients diagnosed with Covid‐19 pneumonia. Patients were followed until home discharge or death. PSI, CURB‐65, SMART‐COP and MuLBSTA severity scores were assessed on admission. Risk scores were related to mortality and ICU admission. Results: About 249 patients, 143 males (57.4%) were included. The mean age was 65.6 + 16.1 years. Factors associates with mortality in the multivariate analysis were age > 80 years (OR: 13.9; 95% CI 3.8‐51.1) (P =.000), lymphocytes < 800 (OR: 2.9; CI 95% 1.1‐7‐9) (P =.040), confusion (OR: 6.3; 95% CI 1.6‐24.7) (P =.008) and NT‐proBNP > 500 pg/mL (OR: 10.1; 95% CI 1.1‐63.1) (P =.039). In predicting mortality, the PSI score: AUC 0.874 (95% CI 0.808‐0.939) and the CURB‐65 score: AUC 0.852 (95% CI 0.794‐0.909) were the ones that obtained the best results. In the need for ICU admission, the SMART‐COP score: AUC 0.749 (95% CI 0.695‐0.820) and the MuLBSTA score: AUC 0.777 (95% CI 0.713‐0.840) were the ones that obtained better results, with significant differences with PSI and CURB‐65. The scores with the lowest value for ICU admission prediction were PSI with AUC of 0.620 (95% CI 0.549‐0.690) and CURB‐65 with AUC of 0.604 (95% CI 0.528‐0.680). Conclusions: Prognosis scores routinely used for CAP (PSI and CURB‐65) were good predictors for mortality in patients with Covid‐19 CAP but not for need of hospitalisation or ICU admission. In the evaluation of Covid‐19 pneumonia, we need scores that allow to decide the appropriate level of care. [ABSTRACT FROM AUTHOR]

Published
2021
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14. A systematic review of security threats and countermeasures in SaaS.

Author

Díaz de León Guillén, Miguel Ángel, Morales-Rocha, Víctor, and Fernández Martínez, Luis Felipe

Subjects
*SOFTWARE as a service, *UNCERTAINTY, *CLASSIFICATION
Abstract

Among the service models provided by the cloud, the software as a service (SaaS) model has had the greatest growth. This service model is an attractive option for organizations, as they can transfer part or all of their IT functions to a cloud service provider. However, there is still some uncertainty about deciding to carry out a migration of all data to the cloud, mainly due to security concerns. The SaaS model not only inherits the security problems of a traditional application, but there are unique attacks and vulnerabilities for a SaaS architecture. Additionally, some of the attacks in this environment are more devastating due to nature of shared resources in the SaaS model. Some of these attacks and vulnerabilities are not yet well known to software designers and developers. This lack of knowledge has negative consequences as it can expose sensitive data of users and organizations. This paper presents a rigorous systematic review using the SALSA framework to know the threats, attacks and countermeasures to mitigate the security problems that occur in a SaaS environment. As part of the results of this review, a classification of threats, attacks and countermeasures in the SaaS environment is presented. [ABSTRACT FROM AUTHOR]

Published
2020
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16. Severe asthma and bronchiectasis.

Author

García-Clemente, Marta, Enríquez-Rodríguez, Ana Isabel, Iscar-Urrutia, Marta, Escobar-Mallada, Beatriz, Arias-Guillén, Miguel, López-González, Francisco Julián, Madrid-Carbajal, Claudia, Pérez-Martínez, Liliana, and Gonzalez-Budiño, Teresa

Subjects
BRONCHIECTASIS, ASTHMA, PULMONARY function tests, CYSTIC fibrosis, DISEASE exacerbation, ASTHMATICS
Abstract

Objective: The aim of our study was to determine the tomographic findings and prevalence of bronchiectasis in our population of patients with severe asthma, and to identify factors associated with the presence of bronchiectasis in these patients. Materials and methods: We retrospectively collected data from the medical histories of patients referred to the asthma unit of our hospital, with a diagnosis of severe asthma between 2015 and 2017. Patients with ABPA, cystic fibrosis, immunodeficiency or systemic disease were excluded. High-resolution thorax-computed tomodensitography (HRCT) was performed in all patients. A standardized protocol was applied in data collection. Results: A total of 108 patients comprising 50 men (46%) and 58 women (54%) were included in the study. Of the 108 patients, 59 (55%) had at least one abnormality detected by HRCT, the most commonly reported abnormalities being bronchiectasis (35%), bronchial wall thickening (33%), emphysema (7%), atelectasis area (6%), mosaic attenuation due to air trapping (4%), and "tree in bud" image (2%). Subjects with bronchiectasis were older (p = 0.001), had a longer asthma history (p = 0.048), had poorer pulmonary function tests with lower FVC (p = 0.031), had more severe bronchial obstruction with lower FEV1 (p = 0.008) and had lower FEV1/FVC (p = 0.003). They also experienced more frequent hospitalizations in the previous year (p = 0.019) and received treatment with omalizumab more frequently (p = 0.049). Plasma eosinophil count and IgE levels were comparable in both groups. In the multivariate analysis, the presence of bronchiectasis was associated with ages older than 40 (OR: 8.3; 95% CI: 1.7–41.2) and chronic airflow obstruction (OR: 5.4; 95% CI: 1.9–15.3). Conclusions: We found that in patients with severe asthma, the prevalence of bronchiectasis is high and that bronchiectasis is associated with a longer asthma history, greater severity and, more importantly, chronic airflow obstruction. These findings are still insufficient evidence to considere features of asthma-bronchiectasis overlap syndrome, a distinct phenotype of severe asthma, but bronchiectasis is a frequent phenomenon leading to a more severe disease with frequent exacerbations. The performance of thorax HRCT on patients with severe asthma can help to evaluate management strategies for the disease in order to improve treatment and prognosis. [ABSTRACT FROM AUTHOR]

Published
2020
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17. Evaluation of parallel programming teaching methodologies: On‐campus versus online methodologies.

Author

Cantabella, Magdalena, Guillén, Miguel Ángel, López, Belén, Muñoz, Andrés, and Cecilia, José M.

Subjects
PARALLEL programming, TEACHING methods, COMPUTER science students, PROGRAMMING languages, LEARNING Management System
Abstract

Contribution: This study reveals that the programming paradigm is relevant to obtain advanced programming skills. Background: Parallel computing has become mandatory for computer science students. The increasing amount of computational resources required by emerging applications need experienced programmers that fully exploit hardware resources. However, the hardware platforms and programming languages to leverage them evolve at a dizzying pace, making very challenging for students the successful learning of the continuously changing high‐performance computing concepts. Research Questions: (a) Is the learning curve of the programming language too steep to begin learning parallel programming fundamentals? (b) Are emergent learning methodologies making even more difficult to learn parallel programming in general? Methodology: It is analyzed the main challenges for succeeding in parallel programming courses at the undergraduate level in two different learning modalities, namely on‐campus and online. It is analyzed the main tools available within a learning management system, showing their impact on online studies. Findings: Our results reveal that the steep learning curve for parallel programming is one of the main barriers to student success, leading to an early drop out of the subject. On‐campus studies mitigate this problem through a close relationship between students and educators. Online studies, however, do not have this tight relationship by its definition. [ABSTRACT FROM AUTHOR]

Published
2020
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20. High rates of tuberculin skin test positivity due to methotrexate therapy: False positive results?

Author

Arias-Guillén, Miguel, Sánchez Menéndez, Marta M., Alperi, Mercedes, Riestra, Sabino, González Budiño, María Teresa, García-Clemente, Marta María, Martínez-González, Susana, Enríquez, Ana Isabel, Alonso-Arias, Rebeca, Palacios Gutiérrez, Juan José, Santibáñez, Miguel, Coto-Segura, Pablo, Camblor, Pablo Martínez, García-Alfonso, Lucía, Morante, Isla, and Escalante, Patricio

Abstract

Abstract Rationale The tuberculin skin test (TST) and interferon ? release assays (IGRAs) are commonly used for latent tuberculosis infection (LTBI) screening. Unexpectedly high TST positivity rates have been reported in patients with rheumatic diseases, and methotrexate is frequently used in this population. We hypothesized that methotrexate use could be associated with false-positive TST results. Objectives To investigate whether treatment with methotrexate and other factors are associated with false-positive TST results in patients with rheumatic diseases. Methods Prospective single-center study conducted between April 2013 and March 2016. Adult patients with rheumatic diseases were evaluated with a TST and two IGRAs for LTBI screening. We compared TST and IGRA results in patients treated and not treated with methotrexate and analyzed for factors associated with positive TST results. Conclusions Our data suggest false-positive TST results associated with methotrexate therapy. Thus, we recommend against using the TST for LTBI screening in patients receiving methotrexate and the preferential use of IGRAs in such patients. Measurements and Main Results We studied 393 patients with rheumatic diseases, including ankylosing spondylitis (ASP, n = 90), rheumatoid arthritis (RA; n = 120), psoriatic arthritis (PA, n = 126), and other disorders (n = 57). The rate of TST positivity varied across the groups: ASP 22.2%, RA 25%, PA 35.7%, and other disorders (22.8%). Positivity rates were lower with IGRAs. Methotrexate use was associated with a statistically significant two-fold increase in the risk of a positive TST and a dose\x96 response relationship was observed. We found no statistically significant associations between methotrexate use and IGRA test positivity. [ABSTRACT FROM AUTHOR]

Published
2018
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21. Acquisition of New Migratory Properties by Highly Differentiated CD4+CD28 null T Lymphocytes in Rheumatoid Arthritis Disease.

Author

Rioseras, Beatriz, Moro-García, Marco Antonio, García-Torre, Alejandra, Bueno-García, Eva, López-Martínez, Rocio, Iglesias-Escudero, Maria, Diaz-Peña, Roberto, Castro-Santos, Patricia, Arias-Guillén, Miguel, and Alonso-Arias, Rebeca

Subjects
RHEUMATOID arthritis, T cells, THERAPEUTICS, AUTOIMMUNE diseases, CYTOKINES, CARDIOVASCULAR diseases
Abstract

Expanded CD4+CD28null T lymphocytes are found in the tissues and peripheral blood of patients with many autoimmune diseases, such as rheumatoid arthritis (RA). These highly differentiated cells present potent inflammatory activity and capability to induce tissue destruction, which has been suggested to predispose to the development of more aggressive disease. In fact, preferential migration to inflammatory sites has been proposed to be a contributing factor in the progression of autoimmune and cardiovascular diseases frequently found in these patients. The functional activity of CD4+CD28null T lymphocytes is largely dependent on interleukin 15 (IL-15), and this cytokine may also act as a selective attractor of these cells to local inflammatory infiltrates in damaged tissues. We have analysed, in RA patients, the migratory properties and transcriptional motility profile of CD4+CD28null T lymphocytes compared to their counterparts CD28+ T lymphocytes and the enhancing role of IL-15. Identification of the pathways involved in this process will allow us to design strategies directed to block effector functions that CD4+CD28null T lymphocytes have in the target tissue, which may represent therapeutic approaches in this immune disorder. [ABSTRACT FROM AUTHOR]

Published
2021
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22. Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2).

Author

Heine-Suñer, Damián, Díaz-Guillén, Miguel Angel, Lange, Alex J., and Rodríguez de Córdoba, Santiago

Subjects
*PHOSPHOFRUCTOKINASE 1, *GENES, *CHEMICAL structure
Abstract

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) is a bifunctional enzyme that catalyzes the synthesis and degradation of Fru-2,6-P2, a key regulator of glycolysis. In mammals, several genes have been found to code for different PFK-2/FBPase-2 isoforms that differ in tissue distribution and enzymatic activities. In the present study, we report the characterization of the PFK-2/FBPase-2 heart isoform gene in humans (PFKFB2), including a full analysis of repetitive sequences and potential transcription binding sites. The genomic sequence of the PFKFB2 gene spans 22 485 bp and contains 15 exons. Heart cDNA analysis shows that PFKFB2 codes for a protein of 505 amino acids with a deduced molecular mass of 58 849 Da. Comparison of the human PFKFB2 gene to the homologous genes in rat and ox outlines a significant conservation of the intron-exon structure, sequence of 5′ and 3′ flanking regions, and simple sequence repetitive element positions. Most important, the human heart PFK-2/FBPase-2 protein was found to retain all the important regulatory sites, as well as the catalytic and substrate binding sites identified in the rat and bovine heart isoforms, suggesting that the human enzyme is regulated in a manner similar to that observed in these organisms. [ABSTRACT FROM AUTHOR]

Published
1998
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23. Replacement of the same lumen-apposing metallic stent for multiple necrosectomy sessions.

Author

Guarner-Argente, Carlos, Colán-Hernández, Juan, Martín, Mar Concepción, Martínez-Guillén, Miguel, Soriano, German, Sainz, Sergio, Guarner, Carlos, and Concepción-Martín, Mar

Subjects
PANCREATITIS treatment, SURGICAL stents, METALS in surgery, GASTROSCOPY, PANCREATITIS, MEDICAL care, PATIENTS, METALS, NECROTIZING pancreatitis, MEDICAL device removal, DIGESTIVE system endoscopic surgery, DISEASE complications
Abstract

The article discusses the feasibility of lumen-apposing metal stent removal and replacement in the middle of necrosectomy sessions. Topics included are the possibility of stent displacement while extracting or fragmentating necrotic material, the presentation of a video of the stent removal and replacement maneuver performed during gastroscopic surgery on an alcoholic acute pancreatitis patient, and the justification for reusing the metal piece. [ABSTRACT FROM AUTHOR]

Published
2015
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