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Your search keyword '"Guan, Xin-Yuan"' showing total 724 results
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724 results on '"Guan, Xin-Yuan"'

14. Roles of heat shock proteins in tumor immune microenvironment

Author

Zhou Qin, Guan Xin-Yuan, and Li Yan

Subjects
heat shock proteins, tumor microenvironment, immune cells, vasculature, Medicine
Abstract

Heat shock proteins (HSPs) are the most abundant molecular chaperones in cells, categorized based on function and molecular weight into HSP families, namely, HSP40, HSP70, HSP90, HSP110, and HSPB (heat shock protein B), et al. HSPs are involved in protein homeostasis by assisting in the correct folding of proteins or incorrectly folded proteins, refolding partially denatured proteins, and degrading damaged proteins. High levels of HSPs have been shown to participate in oncogenesis, progression, and chemotherapy resistance in many cancers. Recently a new range of functions besides chaperons, mostly in modulation of immune responses, have been shown for these extracellular HSPs. Here, we review the interactions between the HSPs and different immune cells, such as T lymphocytes, B cells, dendritic cells, macrophages, NK cells, and myeloid suppressor cells in the tumor microenvironment, as well as tumor vasculature and angiogenesis in tumor formation. The underlying mechanisms of HSPs’ regulation on immune response in tumor microenvironments are also discussed. The understanding of new functions of HSPs in tumor microenvironment may provide critical insights for the development of effective immunotherapies.

Published
2024
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22. Identification and Characterization of Metastasis‐Initiating Cells in ESCC in a Multi‐Timepoint Pulmonary Metastasis Mouse Model.

Author

Wong, Ching Ngar, Zhang, Yu, Ru, Beibei, Wang, Songna, Zhou, Hongyu, Lin, Jiarun, Lyu, Yingchen, Qin, Yanru, Jiang, Peng, Lee, Victor Ho‐Fun, and Guan, Xin‐Yuan

Subjects
LYMPHATIC metastasis, NEURON development, SQUAMOUS cell carcinoma, MORPHOGENESIS, OVERALL survival
Abstract

Metastasis is the biggest obstacle to esophageal squamous cell carcinoma (ESCC) treatment. Single‐cell RNA sequencing analyses are applied to investigate lung metastatic ESCC cells isolated from pulmonary metastasis mouse model at multiple timepoints to characterize early metastatic microenvironment. A small population of parental KYSE30 cell line (Cluster S) resembling metastasis‐initiating cells (MICs) is identified because they survive and colonize at lung metastatic sites. Differential expression profile comparisons between Cluster S and other subpopulations identified a panel of 7 metastasis‐initiating signature genes (MIS), including CD44 and TACSTD2, to represent MICs in ESCC. Functional studies demonstrated MICs (CD44high) exhibited significantly enhanced cell survival (resistances to oxidative stress and apoptosis), migration, invasion, stemness, and in vivo lung metastasis capabilities, while bioinformatics analyses revealed enhanced organ development, stress responses, and neuron development, potentially remodel early metastasis microenvironment. Meanwhile, early metastasizing cells demonstrate quasi‐epithelial‐mesenchymal phenotype to support both invasion and anchorage. Multiplex immunohistochemistry (mIHC) staining of 4 MISs (CD44, S100A14, RHOD, and TACSTD2) in ESCC clinical samples demonstrated differential MIS expression scores (dMISs) predict lymph node metastasis, overall survival, and risk of carcinothrombosis. [ABSTRACT FROM AUTHOR]

Published
2024
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25. A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets

Author

Liu, Ming, Yan, Qian, Sun, Yi, Nam, Yoonhee, Hu, Liang, Loong, Jane HC, Ouyang, Qi, Zhang, Yu, Li, Hao-Long, Kong, Fan-En, Li, Lei, Li, Mei-Mei, Cheng, Wei, Jiang, Ling-Xi, Fang, Shuo, Yang, Xiao-Dong, Mo, Jia-Qiang, Gong, Yuan-Feng, Tang, Yun-Qiang, Li, Yan, Yuan, Yun-Fei, Ma, Ning-Fang, Lin, Ge, Ma, Stephanie, Wang, Ji-Guang, and Guan, Xin-Yuan

Published
2020

33. Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma

Author

Gong, Lanqi, Kwong, Dora Lai-Wan, Dai, Wei, Wu, Pingan, Li, Shanshan, Yan, Qian, Zhang, Yu, Zhang, Baifeng, Fang, Xiaona, Liu, Li, Luo, Min, Liu, Beilei, Chow, Larry Ka-Yue, Chen, Qingyun, Huang, Jinlin, Lee, Victor Ho-Fun, Lam, Ka-On, Lo, Anthony Wing-Ip, Chen, Zhiwei, Wang, Yan, Lee, Anne Wing-Mui, and Guan, Xin-Yuan

Published
2021
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47. A neural‐related gene risk score for head and neck squamous cell carcinoma.

Author

Tao, Zhuo‐ying, Yang, Wei‐fa, Zhu, Wang‐yong, Wang, Lei‐lei, Li, Kar Yan, Guan, Xin‐yuan, and Su, Yu‐xiong

Subjects
STATISTICS, IMMUNE checkpoint inhibitors, PREDICTIVE tests, HEAD & neck cancer, REGRESSION analysis, RISK assessment, T-test (Statistics), GENE expression profiling, SURVIVAL analysis (Biometry), KAPLAN-Meier estimator, CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, DATA analysis, SQUAMOUS cell carcinoma, PROPORTIONAL hazards models, OVERALL survival, IMMUNOTHERAPY
Abstract

Objectives: This study aimed to establish a neural‐related gene risk score (NRGRS) for the prediction of head and neck squamous cell carcinoma prognosis and explore its predictive value on the benefit of immune checkpoint inhibitor therapy. Methods: Based on the transcriptome data of HNSCC patients (n = 546) from The Cancer Genome Atlas database, 37 neural‐related hub genes were identified by weighted gene co‐expression network analysis. Four genes (ITGA5, PYGM, GNG7 and ATP2A3) were identified to construct NRGRS using Lasso‐Cox regression method based on the derivation cohort and validated in the Gene Expression Omnibus cohort (n = 109). The survival analysis was performed to validate the prognostic value of NRGRS and immune characteristics in NRGRS‐defined subgroups were analyzed. Results: NRGRS‐high patients had a worse overall survival than NRGRS‐low patients. Tumors with high NRGRS were more likely to have high infiltration of naive CD4+ T cells, M0, M2 macrophages and resting mast cells, which illustrated suppressive immunity and less benefit from immunotherapy therapy. Conclusion: NRGRS strongly correlates with survival and is a promising biomarker to predict immunotherapy benefits for head and neck cancer patients. This study provides evidence for the potential correlation between neural‐related transcriptome alteration and immune activity. [ABSTRACT FROM AUTHOR]

Published
2024
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