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1. Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia

Author

Stefano Zucchini, Stefano Tumini, Andrea Enzo Scaramuzza, Riccardo Bonfanti, Maurizio Delvecchio, Roberto Franceschi, Dario Iafusco, Lorenzo Lenzi, Enza Mozzillo, Stefano Passanisi, Claudia Piona, Ivana Rabbone, Novella Rapini, Andrea Rigamonti, Carlo Ripoli, Giuseppina Salzano, Silvia Savastio, Riccardo Schiaffini, Angela Zanfardino, Valentino Cherubini, Diabetes Study Group of the Italian Society for Pediatric Endocrinology Diabetes, Albino Claudia Accursia, Aloe Monica, Anzelotti Maria Teresa, Arnaldi Claudia, Barbetti Fabrizio, Bassi Marta, Berioli Maria Giulia, Bernardini Luca, Bertelli Enrica, Biagioni Martina, Bobbio Adriana, Bombaci Bruno, Bonfanti Riccardo, Bonura Clara, Bracciolini Giulia Patrizia, Bruzzese Mariella, Bruzzi Patrizia, Buono Pietro, Buscarino Piera, Cadario Francesco, Calcaterra Valeria, Calzi Elena, Cappa Marco, Cardani Roberta, Cardella Francesca, Cardinale Giuliana Marcella, Casertano Alberto, Castorani Valeria, Cauvin Vittoria, Cenciarelli Valentina, Ceruti Franco, Cherubini Valentino, Chiarelli Francesco, Chiari Giovanni, Cianfarani Stefano, Cicchetti Mario, Cipriano Paola, Cirillo Dante, Citriniti Felice, Coccioli Maria Susanna, Confetto Santino, Contreas Giovanna, Coro Anna, Correddu Antonella, Corsini Elisa, Crino’ Antonino, d’Annunzio Giuseppe, De Berardinis Fiorella, De Donno Valeria, De Filippo Gianpaolo, De Marco Rosaria, De Sanctis Luisa, Del Duca Elisabetta, Delvecchio Maurizio, Deodati Annalisa, Di Bonito Procolo, Di Candia Francesca, Faleschini Elena, Fattorusso Valentina, Favia Anna, Federico Giovanni, Felappi Barbara, Ferrari Mara, Ferrito Lucia, Fichera Graziella, Fontana Franco, Fornari Elena, Franceschi Roberto, Franco Francesca, Franzese Adriana, Frongia Anna Paola, Frontino Giulio, Gaiero Alberto, Galassi Sabrina Maria, Gallo Francesco, Gargantini Luigi, Giani Elisa, Gortan Anna Jolanda, Graziani Vanna, Grosso Caterina, Gualtieri Antonella, Guasti Monica, Guerraggio Lucia Paola, Guzzetti Chiara, Iafusco Dario, Iannicelli Gennaro, Iezzi Maria Laura, Ignaccolo Maria Giovanna, Innaurato Stefania, Inzaghi Elena, Iovane Brunella, Iughetti Lorenzo, Kaufmann Peter, La Loggia Alfonso, Lambertini Anna Giulia, Lapolla Rosa, Lasagni Anna, Lazzaro Nicola, Lazzeroni Pietro, Lenzi Lorenzo, Lera Riccardo, Levantini Gabriella, Lezzi Marilea, Lia Rosanna, Liguori Alice, Lo Presti Donatella, Lombardo Fortunato, Lonero Antonella, Longhi Silvia, Lorubbio Antonella, Lucchesi Sonia, Maccioni Rosella, Macedoni Maddalena, Macellaro Patrizia Cristiana, Madeo Simona Filomena, Maffeis Claudio, Mainetti Benedetta, Maltoni Giulio, Mameli Chiara, Mammì Francesco, Manca Bitti Maria Luisa, Mancioppi Valentina, Manco Melania, Marigliano Marco, Marino Monica, Marsciani Alberto, Matteoli Maria Cristina, Mazzali Elena, Minute Marta, Minuto Nicola, Monti Sara, Morandi Anita,, Morganti Gianfranco, Morotti Elisa, Mozzillo Enza, Musolino Gianluca, Olivieri Francesca, Ortolani Federica, Pampanini Valentina, Pardi Daniela, Pascarella Filomena, Pasquino Bruno, Passanisi Stefano, Patera Ippolita Patrizia, Pedini Annalisa, Pennati Maria Cristina, Peruzzi Sonia, Peverelli Paola, Pezzino Giulia, Piccini Barbara, Piccinno Elvira Eugenia Rosaria, Piona Claudia, Piredda Gavina, Piscopo Alessia, Pistone Carmelo, Pozzi Erica, Prandi Elena, Predieri Barbara, Prudente Sabrina, Pulcina Anna, Rabbone Ivana, Randazzo Emioli, Rapini Novella, Reinstadler Petra, Riboni Sara, Ricciardi Maria Rossella, Rigamonti Andrea, Ripoli Carlo, Rossi Virginia, Rossi Paolo, Rutigliano Irene, Sabbion Alberto, Salvatoni Alessandro, Salvo Caterina, Salzano Giuseppina, Sanseviero Mariateresa, Savastio Silvia, Savini Rosanna, Scanu Mariapiera, Scaramuzza Andrea Enzo, Schiaffini Riccardo, Schiavone Maurizio, Schieven Eleonardo, Scipione Mirella, Secco Andrea, Silvestri Francesca, Siri Giulia, Sogno Valin Paola, Sordelli Silvia, Spiri Daniele, Stagi Stefano, Stamati Filomena Andreina, Suprani Tosca, Talarico Valentina, Tiberi Valentina, Timpanaro Tiziana Antonia Lucia, Tinti Davide, Tirendi Antonina, Tomaselli Letizia Grazia, Toni Sonia, Torelli Cataldo, Tornese Gianluca, Trada Michela,, Trettene Adolfo Andrea, Tumini Stefano, Tumminelli Marilena, Valerio Giuliana, Vandelli Sara, Ventrici Claudia, Zampolli Maria, Zanatta Manuela, Zanfardino Angela, Zecchino Clara, Zonca Silvia, and Zucchini Stefano

Subjects
adolescents, automated insulin delivery, children, hypoglycemia, glucagon, oral glucose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

There has been continuous progress in diabetes management over the last few decades, not least due to the widespread dissemination of continuous glucose monitoring (CGM) and automated insulin delivery systems. These technological advances have radically changed the daily lives of people living with diabetes, improving the quality of life of both children and their families. Despite this, hypoglycemia remains the primary side-effect of insulin therapy. Based on a systematic review of the available scientific evidence, this paper aims to provide evidence-based recommendations for recognizing, risk stratifying, treating, and managing patients with hypoglycemia. The objective of these recommendations is to unify the behavior of pediatric diabetologists with respect to the timely recognition and prevention of hypoglycemic episodes and the correct treatment of hypoglycemia, especially in patients using CGM or advanced hybrid closed-loop systems. All authors have long experience in the specialty and are members of the Italian Society of Pediatric Endocrinology and Diabetology. The goal of treating hypoglycemia is to raise blood glucose above 70 mg/dL (3.9 mmol/L) and to prevent further decreases. Oral glucose at a dose of 0.3 g/kg (0.1 g/kg for children using “smart pumps” or hybrid closed loop systems in automated mode) is the preferred treatment for the conscious individual with blood glucose

Published
2024
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2. The rehabilitation of children and adolescents with severe or medically complicated obesity: an ISPED expert opinion document

Author

Grugni, Graziano, Licenziati, Maria Rosaria, Valerio, Giuliana, Crinò, Antonino, Maffeis, Claudio, Tanas, Rita, Morino, Giuseppe Stefano, Ambruzzi, Amalia, Balsamo, Antonio, Bellone, Simonetta, Bernasconi, Sergio, Bianchi, Vanessa, Bobbio, Adriana, Bruzzi, Patrizia, Buongiovanni, Carmen, Calcagno, Annalisa, Calcaterra, Valeria, Canali, Teresa, Cerutti, Franco, Corciulo, Nicola, Cotugno, Fortunato, Cuccarolo, Giuliano, D’Amico, Osvaldo, Di Bonito, Procolo, Di Candia, Stefania, Di Pietrantonio, Violetta, Di Pietro, Mario, Filannino, Grazia, Fintini, Danilo, Forziato, Claudia, Franceschi, Roberto, Franzese, Adriana, Galeazzi, Daniela, Gargantini, Luigi, Franca Giusti, Lia, Gualtieri, Antonella, Laura Iezzi, Maria, Iughetti, Lorenzo, Lera, Riccardo, Limauro, Raffaele, Lombardi, Francesca, Lucchesi, Sonia, Macchiaroli, Annamaria, Maltoni, Giulio, Manco, Melania, MIRAGLIA DEL GIUDICE, Emanuele, Modestini, Elisabetta, Morandi, Anita, Mozzillo, Enza, Nanni, Laura, Nicolosi, Alessandra, Pellegrin, Maria Chiara, Peruzzi, Sonia, Peverelli, Paola, Purromuto, Salvatore, Ragusa, Letizia, Rosato, Teresa, Salvo, Caterina, Sartori, Chiara, Sticco, Maura, Elisabeth Street, Maria, Trifirò, Giuliana, Vianelli, Patrizia, Yiannakou, Pietro, IAFUSCO, Dario, Grugni, Graziano, Licenziati, Maria Rosaria, Valerio, Giuliana, Crinò, Antonino, Maffeis, Claudio, Tanas, Rita, Morino, Giuseppe Stefano, Ambruzzi, Amalia, Balsamo, Antonio, Bellone, Simonetta, Bernasconi, Sergio, Bianchi, Vanessa, Bobbio, Adriana, Bruzzi, Patrizia, Buongiovanni, Carmen, Calcagno, Annalisa, Calcaterra, Valeria, Canali, Teresa, Cerutti, Franco, Corciulo, Nicola, Cotugno, Fortunato, Cuccarolo, Giuliano, D’Amico, Osvaldo, Di Bonito, Procolo, Di Candia, Stefania, Di Pietrantonio, Violetta, Di Pietro, Mario, Filannino, Grazia, Fintini, Danilo, Forziato, Claudia, Franceschi, Roberto, Franzese, Adriana, Galeazzi, Daniela, Gargantini, Luigi, Franca Giusti, Lia, Gualtieri, Antonella, Iafusco, Dario, Laura Iezzi, Maria, Iughetti, Lorenzo, Lera, Riccardo, Limauro, Raffaele, Lombardi, Francesca, Lucchesi, Sonia, Macchiaroli, Annamaria, Maltoni, Giulio, Manco, Melania, MIRAGLIA DEL GIUDICE, Emanuele, Modestini, Elisabetta, Morandi, Anita, Mozzillo, Enza, Nanni, Laura, Nicolosi, Alessandra, Pellegrin, Maria Chiara, Peruzzi, Sonia, Peverelli, Paola, Purromuto, Salvatore, Ragusa, Letizia, Rosato, Teresa, Salvo, Caterina, Sartori, Chiara, Sticco, Maura, Elisabeth Street, Maria, Trifirò, Giuliana, Vianelli, Patrizia, and Yiannakou, Pietro

Subjects
medicine.medical_specialty, Pediatric Obesity, Adolescent, Pediatric endocrinology, medicine.medical_treatment, 030209 endocrinology & metabolism, Adolescents, Childhood obesity, Children, Multidimensional approach, Obesity, Rehabilitation, Severe obesity, 03 medical and health sciences, Health services, 0302 clinical medicine, 030225 pediatrics, Epidemiology, Medicine, Humans, Child, Competence (human resources), business.industry, medicine.disease, Clinical Psychology, Psychiatry and Mental Health, Family medicine, Expert opinion, Physical therapy, business, Human
Abstract

Severe/medically complicated obesity in childhood, and particularly in adolescence, is a real disability that requires an intensive and continuous approach which should follow the procedures and schedule of rehabilitation medicine. Given the lack of a specific document focusing on children and adolescents, the Childhood Obesity Study Group set out to explore the available evidence for the treatment of severe or medically complicated obesity and to set standards tailored to the specific context of the Italian Health Service. Through a series of meetings and electronic communications, the writing committee (selected from members of the Study Group) selected the key issues, explored the literature and produced a draft document which was submitted to the other experts until the final synthesis was approved by the group. In brief, the following issues were involved: (1) definition and epidemiology; (2) identification of common goals designed to regain functional competence and limit the progression of metabolic and psychological complications; (3) a multi-professional team approach; (4) the care setting. This paper is an expert opinion document on the rehabilitation of severe and medically complicated obesity in children and adolescents produced by experts belonging to the Childhood Obesity Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED).

Published
2017

3. High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: A nationwide longitudinal study, 2004-2013

Author

Cherubini, Valentino, Skrami, Edlira, Ferrito, Lucia, Zucchini, Stefano, Scaramuzza, Andrea, Bonfanti, Riccardo, Buono, Pietro, Cardella, Francesca, Cauvin, Vittoria, Chiari, Giovanni, D'Annunzio, Giuseppe, Frongia, Anna Paola, Iafusco, Dario, Patera, Ippolita Patrizia, Toni, Sonia, Tumini, Stefano, Rabbone, Ivana, Lombardo, Fortunato, Carle, Flavia, Gesuita, Rosaria, Lera, Riccardo, De Luna, Livia, Gualtieri, Antonella, Zecchino, Clara, Piccinno, Elvira, Reinstadler, Petra, Prandi, Elena, Gallo, Francesco, Morganti, Gianfranco, Ripoli, Carlo, La Loggia, Alfonso, Scanu, Piera, Cardinale, Giuliana, Tomaselli, Letizia Grazia, Citriniti, Felice, Lazzaro, Nicola, De Donno, Valeria, Mainetti, Benedetta, Coccioli, Maria Susanna, Maccioni, Rosella, Marongiu, Ugo, Bruzzese, Mariella, Iannilli, Antonio, Pardi, Daniela, Confetto, Santino, Zanfardino, Angela, Iughetti, Lorenzo, Franzese, Adriana, Cadario, Francesco, Milia, Anna Franca, Piredda, Gavina, Soro, Miriam, Correddu, Antonella, Galderisi, Alfonso, De Berardinis, Fiorella, Federico, Giovanni, Zanette, Giorgio, Suprani, Tosca, Pedini, Annalisa, Bitti, Maria Luisa Manca, Delvecchio, Maurizio, Trada, Michela, Meloni, Gianfranco, Gaiero, Alberto, Bulciolu, Pasquale, Guerraggio, Lucia, Faleschini, Elena, Zanatta, Manuela, Salvatoni, Alessandro, Maffeis, Claudio, Arnaldi, Claudia, Cherubini, Valentino, Skrami, Edlira, Ferrito, Lucia, Zucchini, Stefano, Scaramuzza, Andrea, Bonfanti, Riccardo, Buono, Pietro, Cardella, Francesca, Cauvin, Vittoria, Chiari, Giovanni, D'Annunzio, Giuseppe, Frongia, Anna Paola, Iafusco, Dario, Patera, Ippolita Patrizia, Toni, Sonia, Tumini, Stefano, Rabbone, Ivana, Lombardo, Fortunato, Carle, Flavia, Gesuita, Rosaria, Lera, Riccardo, De Luna, Livia, Gualtieri, Antonella, Zecchino, Clara, Piccinno, Elvira, Reinstadler, Petra, Prandi, Elena, Gallo, Francesco, Morganti, Gianfranco, Ripoli, Carlo, La Loggia, Alfonso, Scanu, Piera, Cardinale, Giuliana, Tomaselli, Letizia Grazia, Citriniti, Felice, Lazzaro, Nicola, De Donno, Valeria, Mainetti, Benedetta, Coccioli, Maria Susanna, Maccioni, Rosella, Marongiu, Ugo, Bruzzese, Mariella, Iannilli, Antonio, Pardi, Daniela, Confetto, Santino, Zanfardino, Angela, Iughetti, Lorenzo, Franzese, Adriana, Cadario, Francesco, Milia, Anna Franca, Piredda, Gavina, Soro, Miriam, Correddu, Antonella, Galderisi, Alfonso, De Berardinis, Fiorella, Federico, Giovanni, Zanette, Giorgio, Suprani, Tosca, Pedini, Annalisa, Bitti, Maria Luisa Manca, Delvecchio, Maurizio, Trada, Michela, Meloni, Gianfranco, Gaiero, Alberto, Bulciolu, Pasquale, Guerraggio, Lucia, Faleschini, Elena, Zanatta, Manuela, Salvatoni, Alessandro, Maffeis, Claudio, Arnaldi, Claudia, Cherubini, V., Skrami, E., Ferrito, L., Zucchini, S., Scaramuzza, A., Bonfanti, R., Buono, P., Cardella, F., Cauvin, V., Chiari, G., D'Annunzio, G., Frongia, A. P., Iafusco, D., Patera, I. P., Toni, S., Tumini, S., Rabbone, I., Lombardo, F., Carle, F., Gesuita, R., Lera, R., De Luna, L., Gualtieri, A., Zecchino, C., Piccinno, E., Reinstadler, P., Prandi, E., Gallo, F., Morganti, G., Ripoli, C., La Loggia, A., Scanu, P., Cardinale, G., Tomaselli, L. G., Citriniti, F., Lazzaro, N., De Donno, V., Mainetti, B., Coccioli, M. S., Maccioni, R., Marongiu, U., Bruzzese, M., Iannilli, A., Pardi, D., Confetto, S., Zanfardino, A., Iughetti, L., Franzese, A., Cadario, F., Milia, A. F., Piredda, G., Soro, M., Correddu, A., Galderisi, A., De Berardinis, F., Federico, G., Zanette, G., Suprani, T., Pedini, A., Bitti, M. L. M., Delvecchio, M., Trada, M., Meloni, G., Gaiero, A., Bulciolu, P., Guerraggio, L., Faleschini, E., Zanatta, M., Salvatoni, A., Maffeis, C., and Arnaldi, C.

Subjects
Male, Longitudinal study, Pediatrics, medicine.medical_specialty, endocrine system diseases, Diabetic ketoacidosis, Adolescent, Population, 030209 endocrinology & metabolism, Longitudinal Studie, Logistic regression, Article, Diabetic Ketoacidosis, Diabetic Ketoacidosi, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Diabetes mellitus, Humans, Medicine, Age Factor, Longitudinal Studies, Family history, education, Diabetes, Ketoacidosis, Type 1 diabetes, education.field_of_study, Multidisciplinary, business.industry, Age Factors, nutritional and metabolic diseases, medicine.disease, Ketoacidosis, Diabetes Mellitus, Type 1, Italy, Female, business, Human
Abstract

This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004–2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH

Published
2016

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