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Your search keyword '"Grootens, P."' showing total 16 results
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16 results on '"Grootens, P."'

2. Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Author

Okhuijsen-Pfeifer, C., van der Horst, M. Z., Bousman, C. A., Lin, B., van Eijk, K. R., Ripke, S., Ayhan, Y., Babaoglu, M. O., Bak, M., Alink, W., van Beek, H., Beld, E., Bouhuis, A., Edlinger, M., Erdogan, I. M., Ertuğrul, A., Yoca, G., Everall, I. P., Görlitz, T., Grootens, K. P., Gutwinski, S., Hallikainen, T., Jeger-Land, E., de Koning, M., Lähteenvuo, M., Legge, S. E., Leucht, S., Morgenroth, C., Müderrisoğlu, A., Narang, A., Pantelis, C., Pardiñas, A. F., Oviedo-Salcedo, T., Schneider-Thoma, J., Schreiter, S., Repo-Tiihonen, E., Tuppurainen, H., Veereschild, M., Veerman, S., de Vos, M., Wagner, E., Cohen, D., Bogers, J. P. A. M., Walters, J. T. R., Yağcıoğlu, A. E. Anil, Tiihonen, J., Hasan, A., and Luykx, J. J.

Published
2022
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3. To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

Author

Begemann, Marieke J. H., Thompson, Ilse A., Veling, Wim, Gangadin, Shiral S., Geraets, Chris N. W., van ‘t Hag, Erna, Müller-Kuperus, Sanne J., Oomen, Priscilla P., Voppel, Alban E., van der Gaag, Mark, Kikkert, Martijn J., Van Os, Jim, Smit, H. Filip E., Knegtering, Rikus H., Wiersma, Sybren, Stouten, Luyken H., Gijsman, Harm J., Wunderink, Lex, Staring, Anton B. P., Veerman, Selene R. T., Mahabir, Amrita G. S., Kurkamp, Jörg, Pijnenborg, Gerdina H. M., Veen, Natalie D., Marcelis, Machteld, Grootens, Koen P., Faber, Gunnar, van Beveren, Nico J., Been, Agaath, van den Brink, Truus, Bak, Maarten, van Amelsvoort, Therese A. M. J., Ruissen, Andrea, Blanke, Christine, Groen, Karin, de Haan, Lieuwe, and Sommer, Iris E. C.

Published
2020
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13. Targeted Informed consent : empowering young participants in medical-scientific research

Author

Grootens, P., Broek, J.M. van den, Vries, M.C. de, Dedding, C.W.M., Kalverboer, M.E., Smeets, I., Spaink, H., Molder, H.F.M. te, Rossum, A.M.C. van, Vliet, I.M. van, and Leiden University

Subjects
Participatory research, Health communication, Empowerment, Informed consent, Adolescents, Children, Decision-making
Abstract

Increasingly, pleas are made for extending the involvement of minors in decision-making about participation in pediatric research. However, a number of issues arise from this desired participation of minors. First, involvement in decision-making requires children and adolescents to be adequately informed about what participation in research entails. Second, the plea for increased involvement in decision-making requires further investigation whether children indeed can, should and want to play a role in the decision about research participation. This thesis addresses these issues and thereby contributes to insights in how to empower minors in the context of informed consent for research participation. New informed consent material was developed in close cooperation with children and other end-users, the process of which is described and evaluated. Also, insights in the role that minors can, should and want to play in the informed consent procedure are described. These insights were obtained by reviewing multidisciplinary scientific evidence on the competence of minors, by an ethical reflection on the view on children that we should adopt, and by consulting minors themselves about the perspectives on their role in decision-making. Finally, based on this research, recommendations are provided on how to empower minors in decision-making about research participation.

Published
2016

14. On the use of positive test strategies when diagnosing mental disorders.

Author

van der Heijden, Paul T., Cefo, Irma, Witteman, Cilia L.M., and Grootens, Koen P.

Abstract

Despite the adverse impact diagnostic errors can have, clinical interviewing and decision-making in psychiatric practice have received relatively little empirical attention. When diagnosing patients, clinicians tend to fall back on a specific (heuristic) rule of thumb, the positive test strategy, a confirmatory approach that increases the risk of confirmation bias. A group of 83 clinical psychologists and psychiatrists was asked to give their diagnostic hypotheses about two vignettes. We found them to self-generate significantly (i.e., p <.01; d = 1.57) more confirming than disconfirming questions to test their initial diagnostic impressions, with supervisors considering significantly more differential diagnoses than the less experienced post-grads/residents. When offered a list of 100 potentially relevant diagnostic queries, the supervisors selected fewer confirming and proportionally more disconfirming themes. Our results demonstrate that irrespective of clinical experience mental-health clinicians indeed tend to use a confirmatory thinking style that contrasts with the stricter principle of falsification. More field-based research on this topic is needed, as well as studies probing whether a systematized diagnostic approach is feasible in psychiatric practice and increases diagnostic accuracy and patient satisfaction. • Clinical decision-making in psychiatry may suffer from the use of heuristics. • Confirmatory and positive test strategies raise the risk of confirmation bias. • The principle of falsification may bolster the diagnostic process. • Systematizing diagnostic interviews and disconfirmatory queries are recommended. [ABSTRACT FROM AUTHOR]

Published
2022
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15. An expert-supported monitoring system for patients with chronic obstructive pulmonary disease in general practice: results of a cluster randomised controlled trial.

Author

Van den Bemt, Lisette, Schermer, Tjard R. J., Smeele, Ivo J. M., Boonman-de Winter, Leandra, Van Boxem, Ton, Denis, Joke, Grootens-Stekelenburg, Joke G., Grol, Richard P. T. M., and Van Weel, Chris

Abstract

The article presents information on a cluster randomized controlled trial which determined whether general practice monitoring system with respiratory expert recommendations for general practitioners' management of patients with chronic obstructive monitoring disease (COPD) is effective long-term. The trial which was conducted from July 2005 to February 2008 involved 200 participants in the south-western region of the Netherlands. Analysis of the research findings indicate the ineffectiveness of an expert-supported monitoring system for COPD patients.

Published
2009
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