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570 results on '"Gotlieb, Walter"'

5. Global distribution and career outcomes of international fellows trained in Canadian gynecologic oncology programs

Author

Touhami, Omar, De Guerke, Lara, Teo Fortin, Ly-Ann, Foo, Justin, Provencher, Diane, Samouelian, Vanessa, Cormier, Beatrice, Lau, Susie, Salvador, Shannon, Gotlieb, Walter, Gilbert, Lucy, Laframboise, Stephane, Altman, Alon D, Ghatage, Prafull, Brar, Harinder, Kwon, Janice, Le, Tien, Sebastianelli, Alexandra, Fokom Domgue, Joel, and Plante, Marie

Published
2024
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11. Author Correction: SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria

Author

Xue, Yibo, Morris, Jordan L., Yang, Kangning, Fu, Zheng, Zhu, Xianbing, Johnson, Fraser, Meehan, Brian, Witkowski, Leora, Yasmeen, Amber, Golenar, Tunde, Coatham, Mackenzie, Morin, Geneviève, Monast, Anie, Pilon, Virginie, Fiset, Pierre Olivier, Jung, Sungmi, Gonzalez, Anne V., Camilleri-Broet, Sophie, Fu, Lili, Postovit, Lynne-Marie, Spicer, Jonathan, Gotlieb, Walter H., Guiot, Marie-Christine, Rak, Janusz, Park, Morag, Lockwood, William, Foulkes, William D., Prudent, Julien, and Huang, Sidong

Published
2023
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13. Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification

Author

Thompson, Emily F., Huvila, Jutta, Jamieson, Amy, Leung, Samuel, Lum, Amy, Offman, Saul, Lytwyn, Alice, Sur, Mona Lisa, Hoang, Lynn, Irving, Julie, van der Westhuizen, Nicholas, Morin, Chantale, Bicamumpaka, Cyrille, Azordegan, Nazilla, Gougeon, François, Ennour-Idrissi, Kaoutar, Senz, Janine, McConechy, Melissa K., Aguirre-Hernandez, Rosalia, Lui, Victoria, Kuo, Carolyn, Bell, Cassidy, Salisbury, Taylor, Lawson, James, He, Ellen, Wang, Shanzhao, Chiu, Derek, Kean, Sarah, Samouëlian, Vanessa, Salvador, Shannon, Gotlieb, Walter, Helpman, Limor, Scott, Stephanie, Wohlmuth, Christoph, Vicus, Danielle, Plante, Marie, Talhouk, Aline, Huntsman, David, Parra-Herran, Carlos, Kinloch, Mary, Grondin, Katherine, Gilks, C. Blake, and McAlpine, Jessica N.

Published
2022
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14. Grade and Estrogen Receptor Expression Identify a Subset of No Specific Molecular Profile Endometrial Carcinomas at a Very Low Risk of Disease-Specific Death

Author

Jamieson, Amy, Huvila, Jutta, Chiu, Derek, Thompson, Emily F., Scott, Stephanie, Salvador, Shannon, Vicus, Danielle, Helpman, Limor, Gotlieb, Walter, Kean, Sarah, Samouelian, Vanessa, Köbel, Martin, Kinloch, Mary, Parra-Harran, Carlos, Offman, Saul, Grondin, Katherine, Irving, Julie, Lum, Amy, Senz, Janine, Leung, Samuel, McConechy, Melissa K., Plante, Marie, Kommoss, Stefan, Huntsman, David G., Talhouk, Aline, Gilks, C. Blake, and McAlpine, Jessica N.

Published
2023
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18. Variation in practice in endometrial cancer and potential for improved care and equity through molecular classification

Author

Jamieson, Amy, Huvila, Jutta, Thompson, Emily F., Leung, Samuel, Chiu, Derek, Lum, Amy, McConechy, Melissa, Grondin, Katherine, Aguirre-Hernandez, Rosalia, Salvador, Shannon, Kean, Sarah, Samouelian, Vanessa, Gougeon, Francois, Azordegan, Nazila, Lytwyn, Alice, Parra-Herran, Carlos, Offman, Saul, Gotlieb, Walter, Irving, Julie, Kinloch, Mary, Helpman, Limor, Scott, Stephanie A., Vicus, Danielle, Plante, Marie, Huntsman, David G., Gilks, C. Blake, Talhouk, Aline, and McAlpine, Jessica N.

Published
2022
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24. Factors associated with an increased risk of recurrence in patients diagnosed with high-grade endometrial cancer undergoing minimally invasive surgery: A study of the society of gynecologic oncology of Canada (GOC) community of practice (CoP)

Author

Feigenberg, Tomer, Cormier, Beatrice, Gotlieb, Walter Henri, Jegatheeswaran, Kizanee, Helpman, Limor, Kim, Soyoun Rachel, Lau, Susie, May, Taymaa, Saab, Dima, Plante, Marie, Renaud, Marie Claude, Samouelian, Vanessa, Shamiya, Sarah, Vicus, Danielle, Wright, Kristin, and Kwon, Janice S.

Published
2021
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28. Ascites and Serum Interleukin-10 Levels as a Prognostic Tool for Ovarian Cancer Outcomes.

Author

Guigue, Paul Adrien, Brezinov, Yoav, Yasmeen, Amber, Mbarik, Maroua, Salvador, Shannon, Lau, Susie, Gotlieb, Walter Henri, and Brodeur, Melica Nourmoussavi

Subjects
ASCITES, ACADEMIC medical centers, RECEIVER operating characteristic curves, DATA analysis, OVARIAN tumors, KRUSKAL-Wallis Test, EVALUATION of medical care, RETROSPECTIVE studies, TERTIARY care, MANN Whitney U Test, MULTIVARIATE analysis, KAPLAN-Meier estimator, RESEARCH methodology, STATISTICS, PROGRESSION-free survival, CONFIDENCE intervals, DATA analysis software, INTERLEUKINS, OVERALL survival, NONPARAMETRIC statistics, PROPORTIONAL hazards models
Abstract

Simple Summary: There are no reliable prognostic biomarkers for ovarian cancer. The immune tumor suppressive marker interleukin-10 has been shown to be elevated in cancer, specifically in ovarian cancer. This study aims to correlate interleukin-10 levels in the ascites and sera of ovarian cancer patients to correlate with cancer-related data and outcomes. Our findings suggest a prognostic role for interleukin-10 that may be related to its immunosuppressive function in the tumor microenvironment. Future studies are needed to validate these results. This study highlights a potential target for novel therapeutic approaches. Interleukin-10 (IL-10) has been shown to be present at high levels in the ascites of ovarian cancer (OC) patients; however, little is known about its prognostic value. We sought to correlate IL-10 levels in ascites and sera of OC patients with clinicopathologic characteristics and oncologic outcomes. IL-10 levels and clinical data from biobanked ascites and serum samples of OC patients were evaluated. Receiver operating characteristic curves were used to quantify marker performance and identify IL-10-high and IL-10-low groups. Correlations between IL-10 levels and clinicopathologic data were performed. Survival outcomes were calculated, while the factors affecting them were also investigated. A total of 106 patients had ascites samples, of which 44 serum samples were also available. Mean ascites IL-10 levels were significantly higher in patients with serous histology compared to endometrioid histology (p = 0.024). Fold-change in ascites IL-10 during treatment positively correlated with clinical response, as determined by a change in serum cancer antigen (CA)-125 levels (p = 0.0126). Median progression-free survival (PFS) and overall survival (OS) were shorter in patients with high compared with low ascites IL-10 levels (PFS: 18 versus 60 months; p = 0.007, OS: 42 versus 85 months; p = 0.029). A significant positive correlation was seen between ascites and sera IL-10 levels (p = 0.019). In multivariable analyses, a high ascites IL-10 level was associated with a significantly worse prognosis (PFS hazard ratio (HR) = 1.93; p = 0.02). Patients with high ascites levels of IL-10 have worse outcomes, which are likely reflective of the immunosuppressive effect of IL-10. This highlights its potential role as an immunomodulator in the tumor microenvironment, leading to OC immune evasion. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Evaluating the diagnostic performance of preoperative endometrial biopsies in patients diagnosed with high grade endometrial cancer: A study of the Society of Gynecologic Oncology (GOC) Community of Practice (CoP)

Author

Jegatheeswaran, Kizanee, Cormier, Beatrice, Dube, Samantha, Gotlieb, Walter Henri, Helpman, Limor, Kwon, Janice S., Lau, Susie, Mah, Sarah, May, Taymaa, Saab, Dima, McNeill, Maggie, Plante, Marie, Renaud, Marie Claude, Shamiya, Sarah, Vicus, Danielle, Parra-Herran, Carlos, and Feigenberg, Tomer

Published
2020
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34. Clinicopathological features of women with epithelial ovarian cancer and double heterozygosity for BRCA1 and BRCA2: A systematic review and case report analysis

Author

Le Page, Cécile, Rahimi, Kurosh, Rodrigues, Manuel, Heinzelmann-Schwarz, Viola, Recio, Neil, Tommasi, Stefania, Bataillon, Guillaume, Portelance, Lise, Golmard, Lisa, Meunier, Liliane, Tonin, Patricia N., Gotlieb, Walter, Yasmeen, Amber, Ray-Coquard, Isabelle, Labidi-Galy, S. Intidhar, Provencher, Diane, and Mes-Masson, Anne-Marie

Published
2020
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35. ChatGPT in a gynaecologic oncology multidisciplinary team tumour board: A feasibility study.

Author

Levin, Gabriel, Gotlieb, Walter, Ramirez, Pedro, Meyer, Raanan, and Brezinov, Yoav

Subjects
*LANGUAGE models, *GYNECOLOGIC cancer, *CHATGPT, *ARTIFICIAL intelligence, *CLINICAL medical education
Abstract

The article explores the feasibility of using ChatGPT, an artificial intelligence tool, in gynaecologic oncology tumour boards for endometrial and ovarian cancer cases. ChatGPT 4 provided correct recommendations in two-thirds of cases, with a higher accuracy rate for ovarian cancer compared to endometrial cancer. The study highlights the potential of AI tools in aiding physicians in evidence-based care, especially in high-volume clinics or resource-limited regions. However, further research is needed to assess the tool's credibility and integration into clinical practice. [Extracted from the article]

Published
2025
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39. Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer

Author

Elkholi, Islam E., Di Iorio, Massimo, Fahiminiya, Somayyeh, Arcand, Suzanna L., Han, HyeRim, Nogué, Clara, Behl, Supriya, Hamel, Nancy, Giroux, Sylvie, de Ladurantaye, Manon, Aleynikova, Olga, Gotlieb, Walter H., Côté, Jean-François, Rousseau, François, Tonin, Patricia N., Provencher, Diane, MesMasson, Anne-Marie, Akbari, Mohammad R., Rivera, Barbara, and Foulkes, William D.

Published
2021
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40. SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria

Author

Xue, Yibo, Morris, Jordan L., Yang, Kangning, Fu, Zheng, Zhu, Xianbing, Johnson, Fraser, Meehan, Brian, Witkowski, Leora, Yasmeen, Amber, Golenar, Tunde, Coatham, Mackenzie, Morin, Geneviève, Monast, Anie, Pilon, Virginie, Fiset, Pierre Olivier, Jung, Sungmi, Gonzalez, Anne V., Camilleri-Broet, Sophie, Fu, Lili, Postovit, Lynne-Marie, Spicer, Jonathan, Gotlieb, Walter H., Guiot, Marie-Christine, Rak, Janusz, Park, Morag, Lockwood, William, Foulkes, William D., Prudent, Julien, and Huang, Sidong

Published
2021
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46. Characterizing Pelvic Floor Muscle Function and Morphometry in Survivors of Gynecological Cancer Who Have Dyspareunia: A Comparative Cross-Sectional Study

Author

Cyr, Marie-Pierre, Dumoulin, Chantale, Bessette, Paul, Pina, Annick, Gotlieb, Walter H., Lapointe-Milot, Korine, and Morin, Melanie

Subjects
Cancer survivors -- Health aspects -- Physiological aspects, Pelvic floor -- Health aspects -- Physiological aspects, Dyspareunia -- Diagnosis -- Risk factors, Genital cancer -- Complications and side effects
Abstract

Objective. More than one-half of gynecological cancer survivors are affected by pain during sexual intercourse, also known as dyspareunia. Oncological treatments may result in pelvic floor muscle (PFM) alterations, which are suspected to play a key role in dyspareunia. However, to our knowledge, no study has investigated PFM function and morphometry in this population. The aim of the study was to characterize and compare PFM function and morphometry between gynecological cancer survivors with dyspareunia and asymptomatic women. Methods. Twenty-four gynecological cancer survivors with dyspareunia and 32 women with a history of total hysterectomy but without pelvic pain (asymptomatic women) participated in this comparative cross-sectional study. PFM passive forces (tone), flexibility, stiffness, maximal strength, coordination, and endurance were assessed with an intra-vaginal dynamometric speculum. Bladder neck position, levator plate angle, anorectal angle, and levator hiatal dimensions were measured at rest and on maximal contraction with 3D/4D transperineal ultrasound imaging. Results. Compared with asymptomatic women, gynecological cancer survivors showed heightened PFM tone, lower flexibility, higher stiffness, and lower coordination and endurance. At rest, they had a smaller anorectal angle and smaller levator hiatal dimensions, indicating heightened PFM tone. They also presented fewer changes from rest to maximal contraction for anorectal angle and levator hiatal dimensions, suggesting an elevated tone or altered contractile properties. Conclusions. Gynecological cancer survivors with dyspareunia present with altered PFM function and morphometry. This research therefore provides a better understanding of the underlying mechanisms of dyspareunia in cancer survivors. Impact. Our study confirms alterations in PFM function and morphometry in gynecological cancer survivors with dyspareunia. These findings support the rationale for developing and assessing the efficacy of physical therapy targeting PFM alterations in this population. Keywords: Body Image Distress, Dynamometric Speculum, Dyspareunia, Gynecological Cancer Survivors, Pelvic Floor Muscles, Psychological Distress, Sexual Distress, Sexual Dysfunction, Ultrasound Imaging, Vaginal Length, Introduction Gynecological cancer is one of the most prevalent cancers affecting women. (1,2) Endometrial and cervical cancers are commonly treated with surgery, radiation therapy, or chemotherapy and have high 5-year [...]

Published
2021
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47. Surgery Advances in Gynecologic Tumors: The Evolution and Outcomes of Robotic Surgery for Gynecologic Cancers in a Tertiary Center.

Author

Knigin, David, Brezinov, Yoav, Salvador, Shannon, Lau, Susie, and Gotlieb, Walter H.

Subjects
SURGICAL robots, GYNECOLOGIC cancer, RECTAL surgery, GYNECOLOGIC surgery, TREATMENT effectiveness, GYNECOLOGIC oncology, ONCOLOGIC surgery
Abstract

The integration of innovation into routine clinical practice is faced with many challenges. In 2007, we received the mandate to evaluate how the introduction of a robotic program in gynecologic oncology affected patient-centered care by studying its impact on clinical outcomes and hospital resource utilization. Here we summarize the history and experience of developing a robotic surgery program for gynecologic cancers over 16 years. Analysis of the data indicates that robotic surgery improved perioperative patient clinical parameters, decreased blood loss, complications, and hospital stay, maintained the oncologic outcome, and is cost-effective, resulting in it becoming the dominant surgical approach in gynecologic oncology in a tertiary cancer care institution. [ABSTRACT FROM AUTHOR]

Published
2024
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