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Glipizide stimulates insulin release from incubated pieces of rat pancreatic tissue. The dose-action relationship is characterized by an ED of approximately 0.04 μM, comparable to that of glibenclamide or glisoxepide. Like other sulphonylureas, the insulinotropic action of glipizide over 60 min incubation is barely detectable in the absence of glucose, maximal at intermediate glucose concentrations (1.0 to 1.5 mg/ml), and present but short-lived at a higher glucose level (3.0 mg/ml). [ABSTRACT FROM AUTHOR]