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24. 120-volt Wiring Problems

Author

Glasser, Stephen P.

Subjects
Travel, recreation and leisure
Abstract

Q We own a 2018 NeXus Bentley diesel pusher, and I've had numerous issues with it. It has a V-bus multiplex electrical system; 2,000-Watt inverter; 50-amp, 12-volt distribution panel; and [...]

Published
2020

29. Importance and challenges of studying marketed drugs: what is a phase IV study? Common clinical research designs, registries, and self-reporting systems

Author

Glasser, Stephen P., Salas, Maribel, and Delzell, Elizabeth

Subjects
United States. Food and Drug Administration -- Laws, regulations and rules, Prevention, Laws, regulations and rules, Government regulation, Clinical trials -- Laws, regulations and rules, Adverse drug reactions -- Prevention, Drug approval -- Laws, regulations and rules, Drugs -- Adverse and side effects
Abstract

The new drug application database submitted to the US Food and Drug Administration for drug approval (phases I-III or phases 1-3) is limited both in scope and size. Although randomized [...]

Published
2007

30. Serum Tumor Necrosis Factor-alpha associates with Myocardial Oxygen Demand and Exercise Tolerance in Postmenopausal Women

Author

CARTER, STEPHEN J., BRYAN, DAVID R., NEUMEIER, WILLIAM H., GLASSER, STEPHEN P., and HUNTER, GARY R.

Subjects
Aging, inflammation, atherosclerosis, vasodilation, cytokines, Original Research
Abstract

The functional implications of serum tumor necrosis factor-alpha (TNF-α), a marker of oxidative stress, on hemodynamic parameters at rest and during physical exertion are unclear. The aims of this investigation were to examine the independent associations of TNF-α on myocardial oxygen demand at rest and during submaximal exercise, while also evaluating the association of TNF-α on exercise tolerance. Forty, postmenopausal women, provided blood samples and completed a modified-Balke protocol to measure maximal oxygen uptake (VO2max). Large artery compliance was measured by pulse contour analyses while rate-pressure product (RPP), an index of myocardial oxygen demand, was measured at rest and during two submaximal workloads (i.e., ≈55% and ≈75% VO2max). RPP was calculated by dividing the product of heart rate and systolic blood pressure (via auscultation) by 100. Exercise tolerance corresponded with the cessation of the graded exercise test. During higher-intensity exertion, ≈75% VO2max, multiple linear regression revealed a positive association (r = 0.43; p = 0.015) between TNF-α and RPP while adjusting for maximal heart rate, VO2max, large artery compliance, and percent body fat. Path analyses revealed a significant indirect effect of large artery compliance on exercise tolerance through TNF-α, β = 0.13, CI [0.03, 0.35], indicating greater levels of TNF-α associated with poorer exercise tolerance. These data suggest TNF-α independently associates with myocardial oxygen demand during physical exertion, thus highlighting the utility of higher-intensity efforts to expose important phenomena not apparent at rest. TNF-α also appears to be indirectly associated with the link between large artery compliance and exercise tolerance.

Published
2018

31. Summary of water quality effects from forest practices in the South /

Author

Glasser, Stephen P., United States. Forest Service, U.S. Department of Agriculture, National Agricultural Library, Glasser, Stephen P., and United States. Forest Service

Subjects
Environmental aspects, Forest management, Forests and forestry, Southern States, Water quality
Published
1989

43. Is Medication Adherence Predictive of Cardiovascular Outcomes and Blood Pressure Control? The Systolic Blood Pressure Intervention Trial (SPRINT).

Author

Glasser, Stephen P, Vitolins, Mara, Rocco, Michael V, Still, Carolyn Harmon, Cofield, Stacey S, Haley, William E, and Goff, David

Subjects
SYSTOLIC blood pressure, PATIENT compliance, BLOOD pressure, MYOCARDIAL infarction, HEART failure, MONTREAL Cognitive Assessment, ACUTE coronary syndrome
Abstract

BACKGROUND Adherence to study medications is crucial to evaluating treatment effects in clinical trials. To assess whether in the SPRINT trial, adherence and cardiovascular outcomes are associated regardless of intervention assignment. METHODS This study included 9,361 participants aged ≥50 years, recruited from 102 clinics. Participants were randomized to a Standard Treatment Group (targeted systolic blood pressure [SBP] <140 mm Hg) or an Intensive Treatment Group (targeted SBP <120 mm Hg) and followed for incident cardiovascular events until the study was halted early for benefit. The 8-item Morisky Medication Adherence Scale (MMAS-8) was administered at baseline, and at the 12- and 48-month (or close out) visit. RESULTS Adjusting for covariates, there was no association between the baseline 8-item MMAS-8 and the likelihood of the primary composite endpoint, any of the secondary endpoints, or blood pressure (BP) control. Low adherence was associated with a higher body mass index, SBP, diastolic BP, and Patient Health Questionnaire, and high adherence was associated with a higher Montreal Cognitive Assessment. There was no difference in the MMAS-8 over time by treatment arm assignment. For the primary outcome (a composite of myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes), baseline odds ratios (95% confidence intervals) for the Low vs. Medium and vs. High; and, for Medium vs. High MMAS-8 were 1.02 (0.82–1.28), 1.07 (0.85–1.34), and 1.05 (0.88–1.250). CONCLUSIONS In SPRINT, medication adherence as measured using the MMAS-8 was not associated with outcomes or BP control. [ABSTRACT FROM AUTHOR]

Published
2022
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49. High-fat meal effect on LDL, HDL, and VLDL particle size and number in the Genetics of Lipid-Lowering drugs and diet network (GOLDN): an interventional study

Author

Straka Robert J, Tsai Michael Y, Hopkins Paul N, Kabagambe Edmond K, Oberman Albert, Glasser Stephen P, Wojczynski Mary K, Ordovas Jose M, and Arnett Donna K

Subjects
postprandial lipemia, lipoprotein particles, NMR, high-fat meal, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background Postprandial lipemia (PPL) is likely a risk factor for cardiovascular disease but these changes have not been well described and characterized in a large cohort. We assessed acute changes in the size and concentration of total and subclasses of LDL, HDL, and VLDL particles in response to a high-fat meal. Participants (n = 1048) from the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN) Study who ingested a high-fat meal were included in this analysis. Lipids were measured at 0 hr (fasting), 3.5 hr, and 6 hr after a standardized fat meal. Particle size distributions were determined using nuclear magnetic resonance spectroscopy. Analyses were stratified by baseline triglycerides (normal vs. elevated) and gender. The effect of PPL on changes in lipoprotein subclasses was assessed using repeated measures ANOVA. Results Postprandially, LDL-C, HDL-C, VLDL-C, and triglycerides increased regardless of baseline triglyceride status, with the largest increases in VLDL-C and TG; however, those with elevated triglycerides demonstrated larger magnitude of response. Total LDL particle number decreased over the 6-hour time interval, mostly from a decrease in the number of small LDL particles. Similarly, total VLDL particle number decreased due to reductions in medium and small VLDL particles. Large VLDL particles and chylomicrons demonstrated the largest increase in concentration. HDL particles demonstrated minimal overall changes in total particle number. Conclusions We have characterized the changes in LDL and VLDL particle number, and their subclass patterns following a high-fat meal.

Published
2011
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