499 results on '"Gitler, Aaron"'
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2. Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
3. Neuromodulation modifies α-synuclein spreading dynamics in vivo and the pattern is predicted by changes in whole-brain function
4. It’s me, hi, I solved the problem, it’s TF-seqFISH
5. A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes
6. Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates
7. Mesoscale connections and gene expression empower whole-brain modeling of α-synuclein spread, aggregation, and decay dynamics
8. Singling out motor neurons in the age of single-cell transcriptomics
9. TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
10. The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems
11. A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation
12. Neurotoxic reactive astrocytes induce cell death via saturated lipids
13. p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
14. Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes.
15. Author Correction: Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD
16. ALS Genetics: Gains, Losses, and Implications for Future Therapies
17. Evolution of a Human-Specific Tandem Repeat Associated with ALS
18. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain
19. Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons
20. Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties
21. Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72
22. Axons Gonna Ride ’til They Can’t No More
23. Confirming Pathogenicity of the F386L PSEN1 Variant in a South Asian Family With Early-Onset Alzheimer Disease
24. Pour Some Sugar on TDP(-43)
25. The epidemiology and genetics of Amyotrophic lateral sclerosis in China
26. Ataxin-2 Is Droppin’ Some Knowledge
27. Phosphorylation Leads the Way for Protein Aggregate Disassembly
28. Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
29. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
30. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats
31. Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD
32. Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly
33. LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
34. Internalization, axonal transport and release of fibrillar forms of alpha-synuclein
35. α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models
36. You come at the misfolded proteins, you best not miss
37. New Drugs for Lou Gehrig’s Disease Head for Clinical Trials
38. UNLOCKING THE MYSTERY OF ALS
39. Old moms say, no Sir
40. Efficient Prevention of Neurodegenerative Diseases by Depletion of Starvation Response Factor Ataxin-2
41. Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress
42. Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
43. Raise the Roof: Boosting the Efficacy of a Spinal Muscular Atrophy Therapy
44. Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
45. Targeted next-generation sequencing improves diagnosis of hereditary spastic paraplegia in Chinese patients
46. CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
47. There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS
48. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis
49. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts
50. Neurodegenerative gene’s function is not all about those bases
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