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1. Characterizing Hepatitis Delta in Spain and the gaps in its management

Author

Rodríguez-Tajes, Sergio, Palom, Adriana, Giráldez-Gallego, Álvaro, Moreno, Antonio, Urquijo, Juan José, Rodríguez, Manuel, Alvarez-Argüelles, Marta, Diago, Moisés, García-Eliz, María, Fuentes, Javier, Martínez-Sapiña, Ana María, Castillo, Pilar, Casado, Marta, Pérez-Campos, Elena, Muñoz, Raquel, Hernández-Conde, Marta, Morillas, Rosa María, Granados, Rafael, Miquel, Mireia, Morillas, María Julia, García-Retortillo, Monserrat, Carrión, Jose Antonio, Moreno, José María, Montón, Cristina, González-Santiago, Jesús Manuel, Lorente, Sara, Cabezas, Joaquín, Mateos, Beatriz, Vázquez-Rodríguez, Sergio, Díaz-Fontenla, Fernando, Pinazo, José María, Delgado, Mercè, Pérez-Palacios, Domingo, Horta, Diana, Fernández-Marcos, Cristina, López, Carmen, Calleja, José Luis, Fernández, Inmaculada, García-Samaniego, Javier, Forns, Xavier, Buti, María, and Lens, Sabela

Published
2024
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2. Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial.

Author

Giráldez-Gallego, Álvaro, del Pilar Rodríguez-Seguel, Elisa, Valencia-Martín, Raquel, Morillo-García, Áurea, Salamanca-Rivera, Celia, Ruiz-Pérez, Ricardo, Cuaresma-Duque, María, Rosso-Fernández, Clara, Ferrer-Ríos, María Teresa, Sousa-Martín, José Manuel, Manuel Praena-Fernández, Juan, Desongles-Corrales, Trinidad, Rodríguez-Pérez, Aitana, Camino-Durán, Francisco, Gasch-Illescas, Antonia, Ampuero-Herrojo, Javier, and Manuel Pascasio-Acevedo, Juan

Subjects
HEPATITIS B, BOOSTER vaccines, HEPATITIS C, ORGAN transplant waiting lists, CLINICAL trials, HEPATITIS associated antigen
Published
2024
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3. FRI-406 Real world outcomes of hepatitis delta patients with mild or moderate fibrosis

Author

Lens, Sabela, Kamal, Habiba, d'Almeida, Arno Furquim, Brichler, Segolene, Papatheodoridi, Margarita, Palom, Adriana, Casado-Martin, Marta, Bourgeois, Stefan, Diago, Moises, Lindahl, Karin, Conde, Marta Hernández, Rodríguez, Manuel, Moreno, Christophe, Giráldez-Gallego, Alvaro, Garcia-Samaniego, Francisco Javier, Sersté, Thomas, Cabezas, Joaquin, Delwaide, JeAn, Buti, Maria, Papatheodoridis, George, Roulot, Dominique, Vanwolleghem, Thomas, de Lédinghen, Victor, Aleman, Soo, and Panero, José Luis Calleja

Published
2024
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4. WED-208 - Current status of hepatitis delta in Andalusia: multicenter study

Author

Casado, Marta, Castillo, Anny Camelo, Baena, Pilar Barrera, Perez Jimenez, Ana Belen, Bandera, Jose Pinazo, Viciana, Isabel, Aguilar, Juan Cristobal, Carlos, Juan, Arboledas, Alados, SantaMaria Rodriguez, German Jose, Freyre, Carolina, Villalba, Carmen Molina, Coronas, Joaquin Salas, Luzón-García, M. Pilar, Ruiz, Elena, Fernandez, Teresa Cabezas, del Pino, Pilar, De La Luna, Francisco Franco Álvarez, Cordero, Patricia, Arellano, Encarnación Ramirez, Giráldez-Gallego, Alvaro, Lozano Domínguez, María Carmen, Lopez Garrido, Maria Angeles, Sampedro, Antonio, González-Grande, Rocio, Palop, Begoña, Macías, Manuel, Montiel, Natalia, Molina, Laura Castillo, Roldan, Carolina, Fernández, Carmen Sendra, De La Iglesia Salgado, Alberto, Mate, Carlota Jimeno, del Carmen Domínguez, Maria, Fernández-Sánchez, Fernando, Rosales Zabal, Jose Miguel, and Garcia, Federico Garcia

Published
2023
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5. WED-166 - Characterizing chronic hepatitis delta in Spain and the gaps in its management

Author

Rodriguez-Tajes, Sergio, Palom, Adriana, Giráldez-Gallego, Alvaro, Moreno, Antonio, Urquijo, Juan José, Celada-Sendino, Miriam, Diago, Moises, Eliz, María García, Olmo, Javier Fuentes, Castillo, Pilar, Casado, Marta, Martínez-Sapiña, Ana María, Campos, Elena Pérez, Gómez, Raquel Muñoz, Conde, Marta Hernández, Morillas, Rosa Maria, Granados, Rafael, Miquel, Mireia, Morillas, Julia, García-Retortillo, Montserrat, Carrión, Jose A., Moreno Planas, Jose María, Barciela, Mar Riveiro, Montón, Cristina, Santiago, Jesús González, Lorente, Sara, Llerena, Susana, Cabezas, Joaquín, Muñoz, Beatriz Mateos, Rodríguez, Sergio Vaquez, Diaz, Fernando, Bandera, Jose Pinazo, Gerra, Merce Delgado, Pérez-Palacios, Domingo, Horta, Diana, Marcos, Cristina Fernández, Núñez, Carmen López, Calleja Panero, José Luis, Vázquez, Inmaculada Fernández, Rodríguez, Manuel, Garcia-Samaniego Rey, Francisco Javier, Forns, Xavier, Buti, Maria, and Lens, Sabela

Published
2023
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6. THU018 - Impact of sex and recurrence in the prognosis of alcoholic hepatitis

Author

Gratacós-Gines, Jordi, Rodríguez, Manuel, Giráldez-Gallego, Alvaro, Cabezas, Joaquín, Vázquez, Inmaculada Fernández, Cots, Meritxell Ventura, Horta, Diana, Sánchez-Delgado, Jordi, Acosta-López, Silvia, Varasa, Tomás Artaza, Marti-Aguado, David, Monterde, Vanesa Bernal, Martin-Mateos, Rosa, Clemente, Ana, Tejedor-Tejada, Javier, Bandera, Jose Pinazo, Sala, Margarita, Badia-Aranda, Esther, Sancho, Victoria Aguilera, Tomé, Santiago, Fernández-Rodríguez, Conrado, Caballería, Joan, and Pose, Elisa

Published
2022
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11. Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus

Author

Ontanilla-Clavijo, Guillermo, Praena-Segovia, Julia, Giráldez-Gallego, Álvaro, Cordero-Matía, Elisa, and Sousa-Martín, José Manuel

Subjects
Virus Epstein-Barr, Anemia hemolítica, Epstein-Barr virus, Hepatitis aguda, Acute hepatitis, Hemolytic anemia
Abstract

Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation. El virus Ebstein-Barr, miembro de la familia Herpesviridae, es responsable del síndrome clínico conocido como mononucleosis infecciosa, que consiste principalmente en la triada faringitis, fiebre y linfadenopatía, tras un periodo de incubación de entre 30 y 50 días. La afectación hepática suele darse en el 80-90% de los pacientes de forma autolimitada y transitoria, mientras que es bastante menos frecuente que se produzca ictericia (5%). Desde el punto de vista hematológico puede cursar con anemia hemolítica, anemia aplásica, neutropenia y trombocitopenia. Presentamos un caso clínico de mononucleosis infecciosa que cursó con hepatitis aguda grave y asoció anemia hemolítica severa secundaria a crioaglutininas. Tras descartar otras etiologías y ante la sospecha clínica y posterior confirmación analítica de la asociación antes mencionada, se instauró tratamiento empírico con antivirales (aciclovir + valganciclovir) y corticoides, objetivando mejoría progresiva hasta la resolución completa del cuadro clínico. Creemos, por tanto, que este caso sirve para reforzar el cuerpo de evidencia clínica que apoya esta terapia conjunta en los casos más graves de mononucleosis infecciosa como paso previo al trasplante hepático.

Published
2017

12. SAT146 - Pre-emptive (early) transjugular intrahepatic porto-systemic shunt in the treatment of high-risk acute variceal bleeding. An individual patient data meta-analysis

Author

Garcia Pagan, Juan Carlos, Nicoara-Farcau, Oana, Angrisani, Debora, Monescillo, Alberto, Han, Guohong, Torres, Ferran, Bosch, Jaime, Casanovas, Georgina, Lv, Yong, Fan, Daiming, Bureau, Christophe, Nevens, Frederik, Caca, Karel, Luca, Angelo, Zipprich, Alexander, Procopet, Bogdan, Giraldez-Gallego, Alvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez, Luis, Trebika, Jonel, Genesca, Joan, Palazon, Jose María, Alonso, José Castellote, Rodrigues, Susana G., Gluud, Lise Lotte, Ferlitsch, Prof. Dr. Arnulf, Noronha Ferreira, Carlos Alberto Costa, Mundi, Jose Luis, Grønbæk, Henning, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Gomez, Manuel Romero, Guerra, Manuel Hernández, Casas, Meritxell, Primignani, Massimo, Krag, Aleksander, Calleja Panero, José Luis, Cañete, Nuria, Masnou, Helena, Mössner, Joachim, and Hernandez-Gea, Virginia

Published
2020
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13. FRI278 - Persistently low platelet count and splenomegaly after treatment with oxaliplatin as markers of development of portal sinusoidal vascular disease

Author

Sanchez, Angela Puente, del Pozo, Carmen, Serrano, Marina, Giraldez-Gallego, Alvaro, Luis, Tellez, Martinez, Javier, Magaz, Marta, Ibañez, Luis, Garcia, Julia, Llop, Elba, Álvarez-Navascués, Carmen, Romero-Gutiérrez, Marta, Fortea, Jose Ignacio, Lopez, Carlos Lopez, Albillos, Agustin, Hernandez-Gea, Virginia, Garcia Pagan, Juan Carlos, Bañares, Rafael, and Crespo, Javier

Published
2020
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14. AS103 - Early-tips should be performed in high-risk cirrhotic patients despite the presence of hepatic encephalopathy at admission

Author

Rudler, Marika, Hernandez-Gea, Virginia, Procopet, Bogdan, Giraldez-Gallego, Alvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genesca, Joan, Bureau, Christophe, Jonel, Trebicka, Llop, Elba, Laleman, Wim, Palazon, Jose María, Alonso, José Castellote, Rodrigues, Susana G., Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Ferlitsch, Prof. Dr. Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romanno, Dell’Era, Alessandra, Abraldes, Juan G., Barcelo, Rafael, Senzolo, Marco, Gomez, Manuel Romero, Zipprich, Alexander, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Torres, Ferran, Nevens, Frederik, Calleja Panero, José Luis, Casanovas, Georgina, Jansen, Christian, Albillos, Agustin, Maria, Guardascione, Alvarado, Edilmar, Casas, Meritxell, Robic, Marie-Angèle, Catalina, María-Vega, Sosa, Irene Conejo, Maxime, Mallet, Simona, Tripon, Bosch, Jaime, Garcia Pagan, Juan Carlos, and Thabut, Dominique

Published
2020
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16. SAT-079-Respiratory infection in patients with cirrhosis and acute variceal bleeding on antibiotic prophylaxis: A multicenter observational study of 2138 patients

Author

Martinez, Javier, luis, Tellez, Hernandez-Gea, Virginia, Procopet, Bogdan, Giraldez-Gallego, Alvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez, Luis, Silva-Junior, Gilberto, Genesca, Joan, christophe, Bureau, Llop, Elba, Laleman, Wim, Palazon, Jose María, Castellote, José, Rodrigues, Susana G., Gluud, Lise Lotte, Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodriguez, Manuel, Ferlitsch, Prof. Dr. Arnulf, Mundi, Jose Luis, Granbæk, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romanno, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan, Romero-gómez, Manolo, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Nevens, Frederik, Panero, José Luis Calleja, Jansen, Christian, Robic, Marie Angele, Conejo, Irene, Catalina, Maria-Vega, Rudler, Marika, Bañares, Rafael, Alvarado, Edilmar, Trebicka, Jonel, Guardascione, Maria Anna, Tantau, Marcel, Torres, Ferran, Bosch, Jaime, Carlos, Garcia Pagan Juan, and Albillos, Agustin

Published
2019
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17. PS-023-Factors predicting survival in patients with high-risk acute variceal bleeding treated with pre-emptive (Early)-TIPS

Author

Angrisani, Debora, Hernandez-Gea, Virginia, Procopet, Bogdan, Caca, Karel, Giraldez-Gallego, Alvaro, Amitrano, Lucio, Guardascione, Maria Anna, Villanueva, Candid, Alvarado, Edilmar, Thabut, Dominique, Rudler, Marika, Ibañez, Luis, Bañares, Rafael, Catalina, María-Vega, Turon, Fanny, Albillos, Agustin, Martinez, Javier, Genesca, Joan, Sosa, Irene Conejo, Baiges, Anna, christophe, Bureau, Vinel, Jean Pierre, Robic, Marie-Angele, Sauerbruch, Tilman, TREBICKA, Jonel, Appenrodt, Beate, Jansen, Christian, Llop, Elba, Calleja Panero, José Luis, Laleman, Wim, Nevens, Frederik, Palazon, Jose María, Castellote, José, Rodrigues, Susana G., Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Tantau, Marcel, Magaz, Marta, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez-Guerra, Manuel, Ferrusquia, José, Mössner, Joachim, Sassatelli, Romanno, Dell'Era, Alessandra, Senzolo, Marco, ABRALDES, Juan G, Gomez, Manuel Romero, Zipprich, Alexander, Luca, Angelo, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Casanovas, Georgina, Torres, Ferran, Krag, Aleksander, Bosch, Jaime, Monescillo, Alberto, and GARCIA-PAGAN, Juan-Carlos

Published
2019
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18. Nodular regenerative hyperplasia of the liver and cutaneous T-cell lymphoma: an unreported association

Author

Ciria-Bru, Verónica, Giráldez-Gallego, Álvaro, Pascual-Vaca-Gómez, Diego, Zulueta-Dorado, Teresa, and Nacarino-Mejías, Verónica

Subjects
Mycosis fungoides, Vitamina A, Micosis fungoide, Linfoma cutáneo de células T, Nodular regenerative hyperplasia, Cutaneous T-cell lymphoma, Vitamin A, Hiperplasia nodular regenerativa
Abstract

Nodular regenerative hyperplasia of the liver -a type of non-cirrhotic portal hypertension- is a rare condition of unknown etiopathogenesis that has been associated with multiple disorders, including diverse types of hematologic disease. We report the case of a 36-year-old female patient diagnosed with cutaneous T-cell lymphoma of the mycosis fungoides variety, staged as T2N0M0B0, where a transjugular liver biopsy demonstrated the presence of nodular regenerative hyperplasia with a hepatic venous pressure gradient of 15 mm Hg. The study was triggered by the incidental radiologic finding of hepatomegaly with indirect evidence of portal hypertension. We are not aware of any previous reports on the association of nodular regenerative hyperplasia with mycosis fungoides in the medical literature. La hiperplasia nodular regenerativa hepática -una modalidad de hipertensión portal no cirrótica- es una enfermedad poco frecuente de etiopatogenia desconocida que se ha asociado a multitud de trastornos diversos, incluyendo enfermedades hematológicas de distinta índole. Presentamos el caso de una paciente de 36 años diagnosticada de linfoma cutáneo de células T, tipo micosis fungoide, estadio T2N0M0B0, en la que una biopsia por vía transyugular demostró la existencia de una hiperplasia nodular regenerativa con gradiente de presión venosa hepática de 15 mm Hg; el detonante del estudio fue la aparición radiológica de una hepatomegalia incidental con datos indirectos de hipertensión portal.No nos consta que la asociación entre hiperplasia nodular regenerativa y micosis fungoide esté descrita en la literatura médica.

Published
2014

19. Study of colorectal mortality in the Andalusian population

Author

Cayuela, Aurelio, Rodríguez-Domínguez, Susana, Garzón-Benavides, Marta, Pizarro-Moreno, Ángeles, Giráldez-Gallego, Álvaro, and Cordero-Fernández, Carmen

Subjects
Mortality, Colorectal cancer, Regression analysis
Abstract

Objectives: to provide up-to-date information and to analyze recent changes in colorectal cancer mortality trends in Andalusia during the period of 1980-2008 using joinpoint regression models. Patients and methods: age- and sex-specific colorectal cancer deaths were taken from the official vital statistics published by the Instituto de Estadística de Andalucía for the years 1980 to 2008. We computed age-specific rates for each 5-year age group and calendar year and age-standardized mortality rates per 100,000 men and women. A joinpoint regression analysis was used for trend analysis of standardized rates. Joinpoint regression analysis was used to identify the years when a significant change in the linear slope of the temporal trend occurred. The best fitting points (the "joinpoints") are chosen where the rate significantly changes. Results: mortality from colorectal cancer in Andalusia during the period studied has increased, from 277 deaths in 1980 to 1,227 in 2008 in men, and from 333 to 805 deaths in women. Adjusted overall colorectal cancer mortality rates increased from 7.7 to 17.0 deaths per 100,000 person-years in men and from 6.6 to 9.0 per 100,000 person-years in women Changes in mortality did not evolve similarly for men and women. Age-specific CRC mortality rates are lower in women than in men, which imply that women reach comparable levels of colorectal cancer mortality at higher ages than men. Conclusions: sex differences for colorectal cancer mortality have been widening in the last decade in Andalusia. In spite of the decreasing trends in age-adjusted mortality rates in women, incidence rates and the absolute numbers of deaths are still increasing, largely because of the aging of the population. Consequently, colorectal cancer still has a large impact on health care services, and this impact will continue to increase for many more years.

Published
2011

20. Optimal hepatitis B vaccination schedule for cirrhotic patients: a still unanswered question.

Author

Giráldez‐Gallego, Álvaro, Rodríguez‐Seguel, Elisa, and Manuel Pascasio‐Acevedo, Juan

Subjects
*HEPATITIS B vaccines, *ORGAN transplant waiting lists
Abstract

Prevalence of hepatitis B and A virus markers and vaccination indication in cirrhotic patients evaluated for liver transplantation in Spain. In our opinion, a controlled clinical trial is still necessary to establish the optimal global HBV vaccination schedule for cirrhotic patients and to identify those factors specifically related to vaccine responses in this population. Response to vaccination against hepatitis B virus with a schedule of four 40- g doses in cirrhotic patients evaluated for liver transplantation: Factors associated with a response. [Extracted from the article]

Published
2021
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23. Recurrent alcohol-associated hepatitis is common and is associated with increased mortality.

Author

Gratacós-Ginès J, Ruz-Zafra P, Celada-Sendino M, Martí-Carretero A, Pujol C, Martín-Mateos R, Echavarría V, Frisancho LE, García S, Barreales M, Tejedor-Tejada J, Vázquez-Rodríguez S, Cañete N, Fernández-Carrillo C, Valenzuela M, Martí-Aguado D, Horta D, Quiñones M, Bernal-Monterde V, Acosta S, Artaza T, Pinazo J, Villar-Lucas C, Clemente-Sánchez A, Badia-Aranda E, Giráldez-Gallego Á, Rodríguez M, Sancho-Bru P, Cabezas J, Ventura-Cots M, Fernández-Rodríguez C, Aguilera V, Tomé S, Bataller R, Caballería J, and Pose E

Subjects
Humans, Male, Female, Middle Aged, Risk Factors, Adult, Spain epidemiology, Severity of Illness Index, Incidence, Prognosis, Aged, Hepatitis, Alcoholic mortality, Recurrence, Registries statistics & numerical data
Abstract

Background and Aims: Alcohol relapse after surviving an episode of alcohol-associated hepatitis (AH) is common. However, the clinical features, risk factors, and prognostic implications of recurrent alcohol-associated hepatitis (RAH) are not well described., Approach and Results: A registry-based study was done of patients admitted to 28 Spanish hospitals for an episode of AH between 2014 and 2021. Baseline demographics and laboratory variables were collected. Risk factors for RAH were investigated using Cox regression analysis. We analyzed the severity of the index episodes of AH and compared it to that of RAH. Long-term survival was assessed by Kaplan-Meier curves and log-rank tests. A total of 1118 patients were included in the analysis, 125 (11%) of whom developed RAH during follow-up (median: 17 [7-36] months). The incidence of RAH in patients resuming alcohol use was 22%. The median time to recurrence was 14 (8-29) months. Patients with RAH had more psychiatric comorbidities. Risk factors for developing RAH included age <50 years, alcohol use >10 U/d, and history of liver decompensation. RAH was clinically more severe compared to the first AH (higher MELD, more frequent ACLF, and HE). Moreover, alcohol abstinence during follow-up was less common after RAH (18% vs. 45%, p <0.001). Most importantly, long-term mortality was higher in patients who developed RAH (39% vs. 21%, p = 0.026), and presenting with RAH independently predicted high mortality (HR: 1.55 [1.11-2.18])., Conclusions: RAH is common and has a more aggressive clinical course, including increased mortality. Patients surviving an episode of AH should undergo intense alcohol use disorder therapy to prevent RAH., (Copyright © 2024 American Association for the Study of Liver Diseases.)

Published
2024
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24. Investigating temporal patterns of colorectal cancer incidence in Spain: a comprehensive analysis of age, period and cohort effects, 1990-2019.

Author

Cayuela L, Flox-Benítez G, Peiró Villalba C, Giráldez Gallego Á, and Cayuela Domínguez A

Subjects
Humans, Spain epidemiology, Male, Female, Incidence, Middle Aged, Adult, Aged, Age Factors, Time Factors, Aged, 80 and over, Age Distribution, Sex Distribution, Cohort Studies, Colorectal Neoplasms epidemiology, Cohort Effect
Abstract

Aim: This study aimed to evaluate how age, period, and cohort (A-P-C) impact colorectal cancer (CRC) incidence in Spain from 1990 to 2019., Method: Using data from the Global Burden of Disease Study 2019, we used joinpoint analysis to identify long-term trends and A-P-C modelling to quantify net drift, local drift, longitudinal age curves, and rate ratios (RRs) of period and cohort effects., Results: CRC incidence increased steadily in Spain from 1990 to 2019, with a more significant rise in males than in females. The age standardized rates rose from 84.9 to 129.3 cases per 100,000 in males and from 56.9 to 70.3 cases per 100,000 in females. Joinpoint analysis revealed distinct patterns for men and women: male incidence showed three phases (a surge until 1995, a slowdown until 2012, and a subsequent decrease) while female incidence showed a single increase until 2011 and then stabilized. Local drifts increased in all age groups over 45, with stability in males under 45 and a decrease in females aged 30-39. The risk of CRC increased with age, with males consistently having a higher risk than females. The risk of CRC increased over time for both men and women but at different rates. The risk for cohorts born in the early to mid-20th century peaked in the 1960s and remained stable until the late 1990s., Conclusion: The increasing incidence of CRC in Spain, with distinct patterns by gender and birth cohort, underlines the importance of preventive strategies adapted to temporal and demographic variations to address this public health challenge.

Published
2024
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25. Age, period and cohort effects on gastric cancer mortality in Spain, 1980-2021.

Author

Cayuela L, Giráldez Gallego Á, Garzón Benavides M, Sousa Martín JM, and Cayuela A

Subjects
Male, Female, Humans, Middle Aged, Young Adult, Adult, Spain epidemiology, Cohort Effect, Stomach Neoplasms epidemiology
Abstract

Background: this study aimed to evaluate the effects of age, time period and cohort (A-P-C) on gastric cancer (GC) mortality in Spain from 1980 to 2021., Methods: an ecological trend study was performed (with aggregated data obtained from the Spanish National Statistics Institute (INE). Joinpoint regression software was used to estimate rates by sex and age group (< 35, 35-64, > 64 years) and mortality trends. The National Cancer Institute A-P-C tools were used to assess the effects of age, time of death and birth cohort., Results: GC mortality rates in Spain decreased significantly in both sexes. In the under-35 age group, rates were stable after an initial significant decline. In the 35-64 age group, the decline was more pronounced in males than in females. In the 65+ age group, rates fell significantly for both sexes, but more so for females than for males. The net drift and local drift also showed significant decreases across all age groups from 24 years onwards. GC mortality rates increased with age and decreased with calendar time and successive birth cohorts, regardless of sex. The ratio of age-specific rates between males and females increased with age, and birth cohort relative risk estimates followed a steady downward trend until the mid-1970s, after which the decline stabilized. The relative risk decreased for both sexes, with a more pronounced decrease in males., Conclusion: GC mortality rates in Spain have been decreasing over time and across successive birth cohorts, with a stabilizing trend observed for those under 35 years of age.

Published
2024
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26. Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial.

Author

Giráldez-Gallego Á, Rodríguez-Seguel EDP, Valencia-Martín R, Morillo-García Á, Salamanca-Rivera C, Ruiz-Pérez R, Cuaresma-Duque M, Rosso-Fernández C, Ferrer-Ríos MT, Sousa-Martín JM, Praena-Fernández JM, Desongles-Corrales T, Rodríguez-Pérez A, Camino-Durán F, Gasch-Illescas A, Ampuero-Herrojo J, and Pascasio-Acevedo JM

Subjects
Child, Humans, Immunization, Secondary, Hepatitis B Antibodies, Severity of Illness Index, Liver Cirrhosis complications, Hepatitis B Vaccines, End Stage Liver Disease, Hepatitis B prevention & control
Abstract

Objective: We aimed to compare the response rates between two different hepatitis B virus vaccination schedules for cirrhotic subjects who were non-responders to the first three 40 µg doses (month 0-1-2), and identify factors associated with the final response., Design: A total of 120 cirrhotic patients (72.5% decompensated) were randomised at a 1:1 ratio to receive a single 40 µg booster vaccination at month 6 (classical arm) versus an additional round of three new 40 µg doses administered at monthly intervals (experimental arm). The main outcome was the rate of postvaccinal anti-hepatitis B surface antibodies levels ≥10 mIU/mL., Results: Efficacy by ITT analysis was higher in the experimental arm (46.7%) than in the classical one (25%); OR 2.63, p=0.013. The experimental arm increased response rates compared with the classical one from 31% to 68% (OR 4.72; p=0.007), from 24.4% to 50% (OR 3.09; p=0.012) and from 24.4% to 53.8% (OR 3.62; p=0.007), in Child A, Model for End-Stage Liver Disease (MELD) <15 and MELD-Na<15 patients, respectively. Patients with more advanced liver disease did not benefit from the reinforced scheme. Both regimens showed similar safety profiles. Multivariable analysis showed that the experimental treatment was independently response associated when adjusted across three logistic regression models indicating equivalent cirrhosis severity., Conclusion: For cirrhotic patients, the revaccination of non-responders to the first three dose cycle, with three additional 40 µg doses, achieved significantly better response rates to those obtained with an isolated 40 µg booster dose., Trial Registration Number: NCT01884415., Competing Interests: Competing interests: ÁG-G has received speaker fees from Gilead, Gore, MSD, BMS and Abbvie. MTF-R has received speaker fees from Bayer, Gilead, Abbvie and MSD. JMS-M has received lecture fees from Gilead, Abbvie and Intercept. JA has received speaker fees from Abbvie and Gilead, is an Advisory Board member of Intercept, GMP-Orphan and Novo Nordisk, and is supported by grants from Gilead. JMP-A has received lecture fees from Gilead, Abbvie and Astellas, and is supported by grants from Gilead. For all authors, both fees and grants were unrelated to the submitted work., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2023
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27. Regenerative nodular hyperplasia, portal vein thrombosis and primary myelofibrosis: an unusual triple association.

Author

Sández Montagut VM, Giráldez Gallego Á, and Ontanilla Clavijo G

Subjects
Adult, Focal Nodular Hyperplasia diagnostic imaging, Focal Nodular Hyperplasia surgery, Humans, Male, Primary Myelofibrosis diagnostic imaging, Primary Myelofibrosis surgery, Thrombosis diagnostic imaging, Thrombosis surgery, Tomography, X-Ray Computed, Focal Nodular Hyperplasia complications, Portal Vein, Primary Myelofibrosis complications, Thrombosis complications
Abstract

We report a case of a regenerative nodular hyperplasia with a portal vein cavernomatosis with a subsequent progression to symptomatic, occlusive thrombosis of the superior mesenteric vein. A thorough investigation resulted in a final diagnosis of primary myelofibrosis associated with the V617F mutation in the JAK2 gene.

Published
2018
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28. Hepatic veno-occlusive disease induced by Chinese medicinal herbs.

Author

Mejías Manzano MLÁ, Giráldez Gallego Á, and Serrano Jiménez M

Subjects
Hepatic Veno-Occlusive Disease pathology, Humans, Male, Middle Aged, Pyrrolizidine Alkaloids adverse effects, Drugs, Chinese Herbal adverse effects, Hepatic Veno-Occlusive Disease chemically induced
Abstract

The potential hepatotoxic effects of products containing medicinal herbs, which are increasingly used without adequate control by health authorities, is well known. We report a case of toxic hepatic veno-occlusive disease (HVOD) presumably associated with the use of such herbal remedies.

Published
2017
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29. Canalicular cholestasis induced by anabolic steroids.

Author

Silva Ruiz MDP, Giráldez Gallego Á, and Serrano Jiménez M

Subjects
Biopsy, Cholestasis, Intrahepatic pathology, Humans, Male, Young Adult, Cholestasis, Intrahepatic chemically induced, Testosterone Congeners adverse effects
Abstract

Inappropriate use of anabolic steroids is increasing, usually by younger males in an illicit manner. This is a well-documented case of cholestatic hepatitis attributed to use of anabolic steroids for esthetic and/or athletic purposes.

Published
2017
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30. Post-transfusion hyperhemolysis syndrome following gastrointestinal bleeding secondary to prehepatic portal hypertension.

Author

Mejías Manzano MLÁ, Giráldez Gallego Á, and Sánchez Torrijos YM

Subjects
Adrenal Cortex Hormones therapeutic use, Adult, Blood Transfusion, Female, Gastrointestinal Hemorrhage blood, Humans, Syndrome, Gastrointestinal Hemorrhage complications, Gastrointestinal Hemorrhage etiology, Hemolysis, Hypertension, Portal complications
Abstract

Supportive transfusion represents a basic tool in the management of gastrointestinal (GI) bleeding. However, the use of hemoderivatives is not exempt from risks such as development of hemolysis. We report a case of post-transfusion hyperhemolysis syndrome in a female patient with prehepatic portal hypertension.

Published
2017
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31. Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus.

Author

Ontanilla Clavijo G, Praena Segovia J, Giráldez Gallego Á, Cordero Matía ME, and Sousa Martín JM

Subjects
Acute Disease, Adolescent, Anemia, Hemolytic, Autoimmune diagnosis, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections immunology, Female, Hepatitis, Viral, Human complications, Hepatitis, Viral, Human immunology, Humans, Infectious Mononucleosis complications, Infectious Mononucleosis diagnosis, Infectious Mononucleosis immunology, Severity of Illness Index, Anemia, Hemolytic, Autoimmune virology, Epstein-Barr Virus Infections diagnosis, Hepatitis, Viral, Human diagnosis
Abstract

Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation.

Published
2017
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32. Portal vein thrombosis following endoscopic treatment for gastric varices with N-butyl-2-cyanoacrylate: Management with TIPS.

Author

Márquez-Galisteo C, Giráldez-Gallego Á, Nacarino-Mejías V, Rincón-Gatica A, and López-Ruiz T

Subjects
Aged, Enbucrilate therapeutic use, Female, Hemostasis, Endoscopic methods, Humans, Portasystemic Shunt, Transjugular Intrahepatic, Sclerosing Solutions therapeutic use, Venous Thrombosis therapy, Enbucrilate adverse effects, Esophageal and Gastric Varices therapy, Gastrointestinal Hemorrhage therapy, Hemostasis, Endoscopic adverse effects, Portal Vein, Sclerosing Solutions adverse effects, Venous Thrombosis etiology
Published
2015

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