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2. Patients’, physicians’, nurses’, and pharmacists’ preferences on the characteristics of biologic agents used in the treatment of rheumatic diseases

Author

Scalone L, Sarzi-Puttini P, Sinigaglia L, Montecucco C, Giacomelli R, Lapadula G, Olivieri I, Giardino AM, Cortesi PA, Mantovani LG, and Mecchia M

Subjects
preferences, biologic drugs, rheumatic disease, decision-making, Medicine (General), R5-920
Abstract

Luciana Scalone,1 Piercarlo Sarzi-Puttini,2 Luigi Sinigaglia,3 Carlomaurizio Montecucco,4 Roberto Giacomelli,5 Giovanni Lapadula,6 Ignazio Olivieri,7,8,† Angela Maria Giardino,9 Paolo Angelo Cortesi,1 Lorenzo Giovanni Mantovani,1 Monica Mecchia9On behalf of the CARA Study Group1Centre of Research on Public Health, University of Milano-Bicocca, and CHARTA Foundation, Milan, Italy; 2Rheumatology Unit, L. Sacco University Hospital, 3Rheumatology Unit, G. Pini Hospital, Milan, Italy; 4University of Pavia School of Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; 5Rheumatology Unit School of Medicine, University of L’Aquila, L’Aquila, Italy; 6Rheumatology Unit, University of Bari, Bari, Italy; 7Rheumatology Department of Lucania, San Carlo Hospital of Potenza, Potenza, Italy; 8Madonna delle Grazie Hospital of Matera, Matera, Italy; 9MSD Italy, Rome, Italy†Dr Ignazio Olivieri passed away on July 28, 2017Objective: To estimate preferences in relevant treatment characteristics evaluated by different groups involved in the management of patients with rheumatic diseases.Subjects and methods: We surveyed patients with rheumatic diseases, and rheumatologists, nurses, and pharmacists with experience in treatment with/provision of biologic drugs for these patients. Through a discrete choice experiment, participants evaluated 16 possible scenarios in which pairs of similarly efficacious treatments were described with six characteristics: 1) frequency of administration; 2) mode and place of administration; 3) manner, helpfulness, efficiency, and courtesy of health personnel; 4) frequency of reactions at the site of drug administration; 5) severity of generalized undesired/allergic reactions; and 6) additional cost. The direction and strength of preferences toward each characteristic level and the relative importance of each characteristic were estimated through a random-effects conditional logistic regression model.Results: In total, 513 patients, 110 rheumatologists, 51 nurses, and 46 pharmacists from 30 centers in Italy participated. Characteristics 3, 4, and 6 were the most important for every subgroup; 1 was least important for patients and rheumatologists, 2 was least important for pharmacists, and 2 and 5 were least important for nurses. For characteristic 2, pharmacists preferred subcutaneous self-injection with a syringe; nurses preferred assisted infusion at an infusion center close to the patient’s home; patients and rheumatologists preferred subcutaneous self-injection with a pen.Conclusion: The different preferences for some characteristics shown by the different groups can play an important role, together with purely clinical aspects, in the choice and consequent benefit of treatments, contributing also to a more satisfactory use of resources.Keywords: preferences, biologic drugs, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, decision making

Published
2018

4. A fast automatic plate changer for the analysis of nuclear emulsions

Author

Balestra, S., Bertolin, A., Bozza, C., Calligola, P., Cerroni, R., D'Ambrosio, N., Degli Esposti, L., De Lellis, G., De Serio, M., Di Capua, F., Di Crescenzo, A., Di Ferdinando, D., Di Marco, N., Dusini, S., Esposito, L.S., Fini, R.A., Giacomelli, G., Giacomelli, R., Grella, G., Ieva, M., Kose, U., Longhin, A., Mandrioli, G., Mauri, N., Medinaceli, E., Monacelli, P., Muciaccia, M.T., Pasqualini, L., Pastore, A., Patrizii, L., Pozzato, M., Pupilli, F., Rescigno, R., Rosa, G., Ruggieri, A., Russo, A., Sahnoun, Z., Simone, S., Sioli, M., Sirignano, C., Sirri, G., Stellacci, S.M., Strolin, P., Tenti, M., Tioukov, V., Togo, V., and Valieri, C.

Published
2013
Full Text
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7. Advanced diagnostic imaging and intervention in tendon diseases

Author

Bruno, F., Palumbo, P., Arrigoni, F., Mariani, S., Aringhieri, G., Carotti, M., Natella, R., Zappia, M., Cipriani, P., Giacomelli, R., Di Cesare, E., Splendiani, A., Masciocchi, C., and Barile, A.

Subjects
Tendons, tendinosis, T2 mapping, tendon, ultrasound elastography, Humans, Review, Musculoskeletal Diseases, MRI, Tendinosis, Tendon, Ultrasound elastography, musculoskeletal system, Magnetic Resonance Imaging
Abstract

Degenerative tendon pathology represents one of the most frequent and disabling musculoskeletal disorders. Diagnostic radiology plays a fundamental role in the clinical evaluation of tendon pathologies. Moreover, several minimally invasive treatments can be performed under imaging guidance to treat tendon disorders, maximizing the efficacy and reducing procedural complications. In this review article we describe the most relevant diagnostic features of conventional and advanced US and MRI imaging in tendon disorders, along with the main options for image-guided intervention. (www.actabiomedica.it)

Published
2020

9. Development and implementation of the AIDA International Registry for patients with Behçet's disease

Author

Vitale, A, Della Casa, F, Ragab, G, Almaghlouth, Ia, Lopalco, G, Pereira, Rm, Guerriero, S, Govoni, M, Sfikakis, Pp, Giacomelli, R, Ciccia, F, Monti, S, Ruscitti, P, Piga, M, Lomater, C, Tufan, A, Opris-Belinski, D, Emmi, G, Hernández-Rodríguez, J, Şahin, A, Sebastiani, Gd, Bartoloni, E, Akkoç, N, Gündüz, Ös, Cattalini, M, Conti, Giorgio, Hatemi, G, Maier, A, Parronchi, P, Del Giudice, E, Erten, S, Insalaco, A, Li Gobbi, F, Maggio, Mc, Shahram, F, Caggiano, V, Hegazy, Mt, Asfina, Kn, Morrone, M, Prado, Ll, Dammacco, R, Ruffilli, F, Arida, A, Navarini, L, Pantano, I, Cavagna, L, Conforti, A, Cauli, A, Marucco, Em, Kucuk, H, Ionescu, R, Mattioli, I, Espinosa, G, Araújo, O, Karkaş, B, Canofari, C, Sota, J, Laymouna, Ah, Bedaiwi, Aa, Colella, S, Giardini, Ham, Albano, V, Lo Monaco, A, Fragoulis, Ge, Kardas, Rc, Berlengiero, V, Hussein, Ma, Ricci, F, La Torre, F, Rigante, Donato, Więsik-Szewczyk, E, Frassi, M, Gentileschi, S, Tosi, Gm, Dagostin, Ma, Mahmoud, Aaa, Tarsia, M, Alessio, G, Cimaz, R, Giani, T, Gaggiano, C, Iannone, F, Cipriani, P, Mourabi, M, Spedicato, V, Barneschi, S, Aragona, E, Balistreri, A, Frediani, B, Fabiani, C, Cantarini, L, Autoinflammatory Diseases Alliance (AIDA) Network, Vitale, Antonio, Della Casa, Francesca, Ragab, Gaafar, Almaghlouth, Ibrahim A, Lopalco, Giuseppe, Pereira, Rosa Maria, Guerriero, Silvana, Govoni, Marcello, Sfikakis, Petros P, Giacomelli, Roberto, Ciccia, Francesco, Monti, Sara, Ruscitti, Piero, Piga, Matteo, Lomater, Claudia, Tufan, Abdurrahman, Opris-Belinski, Daniela, Emmi, Giacomo, Hernández-Rodríguez, José, Şahin, Ali, Sebastiani, Gian Domenico, Bartoloni, Elena, Akkoç, Nurullah, Gündüz, Özgül Soysal, Cattalini, Marco, Conti, Giovanni, Hatemi, Gulen, Maier, Armin, Parronchi, Paola, Del Giudice, Emanuela, Erten, Sukran, Insalaco, Antonella, Li Gobbi, Francesca, Maggio, Maria Cristina, Shahram, Farhad, Caggiano, Valeria, Hegazy, Mohamed Tharwat, Asfina, Kazi Nur, Morrone, Maria, Prado, Leandro L, Dammacco, Rosanna, Ruffilli, Francesca, Arida, Aikaterini, Navarini, Luca, Pantano, Ilenia, Cavagna, Lorenzo, Conforti, Alessandro, Cauli, Alberto, Marucco, Elena Maria, Kucuk, Hamit, Ionescu, Ruxandra, Mattioli, Irene, Espinosa, Gerard, Araújo, Olga, Karkaş, Burak, Canofari, Claudia, Sota, Jurgen, Laymouna, Ahmed Hatem, Bedaiwi, Asma A, Colella, Sergio, Giardini, Henrique Ayres M, Albano, Valeria, Lo Monaco, Andrea, Fragoulis, George E, Kardas, Riza Can, Berlengiero, Virginia, Hussein, Mohamed A, Ricci, Francesca, La Torre, Francesco, Rigante, Donato, Więsik-Szewczyk, Ewa, Frassi, Micol, Gentileschi, Stefano, Tosi, Gian Marco, Dagostin, Marilia Ambiel, Mahmoud, Ayman Abdel-Monem Ahmed, Tarsia, Maria, Alessio, Giovanni, Cimaz, Rolando, Giani, Teresa, Gaggiano, Carla, Iannone, Florenzo, Cipriani, Paola, Mourabi, Mariam, Spedicato, Veronica, Barneschi, Sara, Aragona, Emma, Balistreri, Alberto, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca

Subjects
Adult, Registrie, Autoinflammatory disease, Registry, Settore MED/16 - REUMATOLOGIA, precision medicine, behçet’s disease, Settore MED/38 - Pediatria Generale E Specialistica, Retrospective Studie, Internal Medicine, Humans, Prospective Studies, Registries, Child, international registry, Retrospective Studies, Behçet's disease, autoinflammatory diseases, rare diseases, uveitis, Behcet Syndrome, Prospective Studie, Uveiti, Emergency Medicine, Rare disease, Human
Abstract

Purpose of the present paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients with Behçet’s disease (BD). The Registry is a clinical physician-driven non-population- and electronic-based instrument implemented for the retrospective and prospective collection of real-life data about demographics, clinical, therapeutic, laboratory, instrumental and socioeconomic information from BD patients; the Registry is based on the Research Electronic Data Capture (REDCap) tool, which is thought to collect standardised information for clinical real-life research, and has been realised to change over time according to future scientific acquisitions and potentially communicate with other existing and future Registries dedicated to BD. Starting from January 31st, 2021, to February 7th, 2022, 110 centres from 23 countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 5993 fields organised into 16 instruments, including patient’s demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. The development of the AIDA International Registry for BD patients will facilitate the collection of standardised data leading to real-world evidence, enabling international multicentre collaborative research through data sharing, international consultation, dissemination of knowledge, inclusion of patients and families, and ultimately optimisation of scientific efforts and implementation of standardised care.Trial registration NCT05200715 in 21/01/2022.

Published
2022

10. Correction to: Impact of smoking habit on adult-onset Still’s disease prognosis, findings from a multicentre observational study (Clinical Rheumatology, (2022), 41, 3, (641-647), 10.1007/s10067-021-05929-8)

Author

Ruscitti, P., Di Cola, I., Berardicurti, O., Conforti, A., Iacono, D., Pantano, I., Rozza, G., Rossi, S., De Stefano, L., Balduzzi, S., Vitale, A., Caso, F., Costa, L., Prete, M., Navarini, L., Atzeni, F., Guggino, G., Perosa, F., Cantarini, L., Frediani, B., Montecucco, C., Ciccia, F., Giacomelli, R., and Cipriani, P.

Published
2022

11. Development and Implementation of the AIDA International Registry for Patients With Still's Disease

Author

Vitale, A. Della Casa, F. Lopalco, G. Pereira, R.M. Ruscitti, P. Giacomelli, R. Ragab, G. La Torre, F. Bartoloni, E. Del Giudice, E. Lomater, C. Emmi, G. Govoni, M. Maggio, M.C. Maier, A. Makowska, J. Ogunjimi, B. Sfikakis, P.P. Sfriso, P. Gaggiano, C. Iannone, F. Dagostin, M.A. Di Cola, I. Navarini, L. Ahmed Mahmoud, A.A. Cardinale, F. Riccucci, I. Paroli, M.P. Marucco, E.M. Mattioli, I. Sota, J. Abbruzzese, A. Antonelli, I.P.B. Cipriani, P. Tufan, A. Fabiani, C. Ramadan, M.M. Cattalini, M. Kardas, R.C. Sebastiani, G.D. Giardini, H.A.M. Hernández-Rodríguez, J. Mastrorilli, V. Więsik-Szewczyk, E. Frassi, M. Caggiano, V. Telesca, S. Giordano, H.F. Guadalupi, E. Giani, T. Renieri, A. Colella, S. Cataldi, G. Gentile, M. Fabbiani, A. Al-Maghlouth, I.A. Frediani, B. Balistreri, A. Rigante, D. Cantarini, L. The Autoinflammatory Diseases Alliance (AIDA) Network

Abstract

Objective: Aim of this paper is to present the design, construction, and modalities of dissemination of the AutoInflammatory Disease Alliance (AIDA) International Registry for patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), which are the pediatric and adult forms of the same autoinflammatory disorder. Methods: This Registry is a clinical, physician-driven, population- and electronic-based instrument implemented for the retrospective and prospective collection of real-world data. The collection of data is based on the Research Electronic Data Capture (REDCap) tool and is intended to obtain evidence drawn from routine patients' management. The collection of standardized data is thought to bring knowledge about real-life clinical research and potentially communicate with other existing and future Registries dedicated to Still's disease. Moreover, it has been conceived to be flexible enough to easily change according to future scientific acquisitions. Results: Starting from June 30th to February 7th, 2022, 110 Centers from 23 Countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 4449 fields organized into 14 instruments, including patient's demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. Conclusions: This international Registry for patients with Still's disease will allow a robust clinical research through collection of standardized data, international consultation, dissemination of knowledge, and implementation of observational studies based on wide cohorts of patients followed-up for very long periods. Solid evidence drawn from “real-life” data represents the ultimate goal of this Registry, which has been implemented to significantly improve the overall management of patients with Still's disease. NCT 05200715 available at https://clinicaltrials.gov/. Copyright © 2022 Vitale, Della Casa, Lopalco, Pereira, Ruscitti, Giacomelli, Ragab, La Torre, Bartoloni, Del Giudice, Lomater, Emmi, Govoni, Maggio, Maier, Makowska, Ogunjimi, Sfikakis, Sfriso, Gaggiano, Iannone, Dagostin, Di Cola, Navarini, Ahmed Mahmoud, Cardinale, Riccucci, Paroli, Marucco, Mattioli, Sota, Abbruzzese, Antonelli, Cipriani, Tufan, Fabiani, Ramadan, Cattalini, Kardas, Sebastiani, Giardini, Hernández-Rodríguez, Mastrorilli, Więsik-Szewczyk, Frassi, Caggiano, Telesca, Giordano, Guadalupi, Giani, Renieri, Colella, Cataldi, Gentile, Fabbiani, Al-Maghlouth, Frediani, Balistreri, Rigante and Cantarini.

Published
2022

12. Addressing the clinical unmet needs in primary Sjögren's Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts

Author

Pezoulas, V.C. Goules, A. Kalatzis, F. Chatzis, L. Kourou, K.D. Venetsanopoulou, A. Exarchos, T.P. Gandolfo, S. Votis, K. Zampeli, E. Burmeister, J. May, T. Marcelino Pérez, M. Lishchuk, I. Chondrogiannis, T. Andronikou, V. Varvarigou, T. Filipovic, N. Tsiknakis, M. Baldini, C. Bombardieri, M. Bootsma, H. Bowman, S.J. Shahnawaz Soyfoo, M. Parisis, D. Delporte, C. Devauchelle-Pensec, V. Pers, J.-O. Dörner, T. Bartoloni, E. Gerli, R. Giacomelli, R. Jonsson, R. Ng, W.-F. Priori, R. Ramos-Casals, M. Sivils, K. Skopouli, F. Torsten, W. A. G. van Roon, J. Xavier, M. De Vita, S. Tzioufas, A.G. Fotiadis, D.I.

Abstract

For many decades, the clinical unmet needs of primary Sjögren's Syndrome (pSS) have been left unresolved due to the rareness of the disease and the complexity of the underlying pathogenic mechanisms, including the pSS-associated lymphomagenesis process. Here, we present the HarmonicSS cloud-computing exemplar which offers beyond the state-of-the-art data analytics services to address the pSS clinical unmet needs, including the development of lymphoma classification models and the identification of biomarkers for lymphomagenesis. The users of the platform have been able to successfully interlink, curate, and harmonize 21 regional, national, and international European cohorts of 7,551 pSS patients with respect to the ethical and legal issues for data sharing. Federated AI algorithms were trained across the harmonized databases, with reduced execution time complexity, yielding robust lymphoma classification models with 85% accuracy, 81.25% sensitivity, 85.4% specificity along with 5 biomarkers for lymphoma development. To our knowledge, this is the first GDPR compliant platform that provides federated AI services to address the pSS clinical unmet needs. © 2022 The Author(s)

Published
2022

14. GENDER AND FIBROMYALGIA SEVERITY: REAL LIFE DATA FROM THE ITALIAN REGISTRY

Author

Batticciotto, A, Campanaro, F, Atzeni, F, Alciati, A, Di Carlo, M, Bazzichi, L, Govoni, M, Biasi, G, Di Franco, M, Mozzani, F, Gremese, E, Dagna, L, Fischetti, F, Giacomelli, R, Guiducci, S, Guggino, G, Bentivegna, M, Gerli, R, Salvarani, C, Bajocchi, G, Ghini, M, Iannone, F, Giorgi, V, Farah, S, Bonazza, S, Barbagli, S, Gioia, C, Capacci, A, Cavalli, G, Carubbi, F, Nacci, F, Ilenia, R, Sinigaglia, L, Cutolo, M, Cappelli, A, Sarzi-Puttini, P, Salaffi, F, Batticciotto, A, Campanaro, F, Atzeni, F, Alciati, A, Di Carlo, M, Bazzichi, L, Govoni, M, Biasi, G, Di Franco, M, Mozzani, F, Gremese, E, Dagna, L, Fischetti, F, Giacomelli, R, Guiducci, S, Guggino, G, Bentivegna, M, Gerli, R, Salvarani, C, Bajocchi, G, Ghini, M, Iannone, F, Giorgi, V, Farah, S, Bonazza, S, Barbagli, S, Gioia, C, Capacci, A, Cavalli, G, Carubbi, F, Nacci, F, Ilenia, R, Sinigaglia, L, Cutolo, M, Cappelli, A, Sarzi-Puttini, P, and Salaffi, F

Subjects
Fibromyalgia, Rheumatology
Abstract

Background: Fibromyalgia (FM) patients report chronic widespread pain, fatigue, cognitive difficulties and sleep disturbances, often associated with anxiety and/or depression (1). FM syndrome more frequently affects women and many papers describe gender-related differences in the perception, description and expression of pain (2), but up to now, the impact of gender on the clinical severity of FM is still a controversial topic. Objectives: The aim of this study was to analyse the data from a web-based registry of FM patients in order to detect a relationship between gender and disease severity. Methods: Adult patients with FM, diagnosed on the basis of the 2010/2011 American College of Rheumatology (ACR) diagnostic criteria (3), were recruited at 19 Italian rheumatology centres between November 2018 and April 2019. Those affected by other conditions that could interfere with the assessment of FM, e.g. psychiatric disorders, were excluded from the study. The severity of the disease was evaluated by validated FM-specific questionnaires: the revised Fibromyalgia Impact Questionnaire (FIQR) (4), the modified Fibromyalgia Assessment Status (ModFAS) questionnaire (5), and the Polysymptomatic Distress Scale (PDS) (6). The data obtained were collected in the Italian Fibromyalgia Registry, an online registry created with the support of the Italian Society of Rheumatology (SIR). Results: We analyse data from 2.381 patients affected by FM, 2.184 females (91.7%) and 197 males. No significant differences in mean age, disease duration, or BMI between the two genders were reported. The women expressed greater disease burden as indicated by higher scores for each completed test: higher mean ModFAS score (25.23 ± 8.83 Vs 23.37 ± 9.22; p = 0.005), mean FIQR score (58.62 ± 23.22 Vs 51.68 ± 23.06; p

Published
2021

15. Influence of the age at diagnosis in the disease expression of primary Sjögren's syndrome: Analysis of 12,753 patients from the Sjögren Big Data Consortium

Author

Retamozo, S., Acar-Denizli, N., Horváth, I. F., Ng, W. -F, Rasmussen, A., Dong, X., Li, X., Baldini, C., Olsson, P., Priori, R., Seror, R., Gottenberg, J. -E, Kruize, A. A., Hernandez-Molina, G., Vissink, A., Sandhya, P., Armagan, B., Quartuccio, L., Sebastian, A., Praprotnik, S., Bartoloni, E., Kwok, S. -K, Kvarnstrom, M., Rischmueller, M., Soláns-Laqué, R., Sene, D., Pasoto, S. G., Suzuki, Y., Isenberg, D. A., Valim, V., Nordmark, G., Nakamura, H., Virginia Trevisani, Hofauer, B., Sisó-Almirall, A., Giacomelli, R., Devauchelle-Pensec, V., Bombardieri, M., Atzeni, F., Hammenfors, D., Maure, B., Carsons, S. E., Gheita, T., Sánchez-Berná, I., López-Dupla, M., Morel, J., Inanç, N., Fonseca-Aizpuru, E., Morcillo, C., Vollenweider, C., Melchor, S., Vázquez, M., Díaz-Cuiza, E., Consani-Fernández, S., De-Miguel-Campo, B., Szántó, A., Bombardieri, S., Gattamelata, A., Hinrichs, A., Sánchez-Guerrero, J., Danda, D., Kilic, L., Vita, S., Wiland, P., Gerli, R., Park, S. -H, Wahren-Herlenius, M., Bootsma, H., Mariette, X., Ramos-Casals, M., Brito-Zerón, P., Translational Immunology Groningen (TRIGR), and Personalized Healthcare Technology (PHT)

Subjects
immunological markers, MANIFESTATIONS, age, Sjogren's syndrome, ONSET, YOUNG, MANAGEMENT, LYMPHOMA, disease phenotype, CLASSIFICATION CRITERIA, CONSENSUS, PROJECT, SALIVARY FLOW
Abstract

Objective. To analyse how the main components of the disease phenotype (sicca symptoms, diagnostic tests, immunological markers and systemic disease) can be driven by the age at diagnosis of primary Sjogren's syndrome (pSS). Methods. By January 2021, the participant centres had included 12,753 patients from 25 countries that fulfilled the 2002/2016 classification criteria for pSS. The age at diagnosis was defined as the time when the attending physician confirmed fulfilment of the criteria. Patients were clustered according to age at diagnosis. 50 clusters with more than 100 observations (from 27 to 76 years) were used to study the influence of the age at diagnosis in the disease expression. Results. There was a consistent increase in the frequency of oral dryness according to the age at diagnosis, with a frequency of 95% in those diagnosed at the oldest ages. The smooth curves that best fitted a linear model were the frequency of dry mouth (adjusted R-2 0.87) and the frequency of abnormal oral tests (adjusted R-2 0.72). Therefore, for each 1-year increase in the age at diagnosis, the frequency of dry mouth increased by 0.13%, and the frequency of abnormal oral diagnostic tests by 0.11%. There was a consistent year-by-year decrease in the frequency of all autoantibodies and immunological markers except for cryoglobulins. According to the linear models, for each 1-year increase in the age at diagnosis, the frequency of a positive result decreased by 0.57% (for anti-Ro antibodies), 0.47% (for RF) and 0.42% (for anti-La antibodies). The ESSDAI domains which showed a more consistent decrease were glandular and lymph node involvement (for each 1-year increase in the age at diagnosis, the frequency of activity decreased by 0.18%), and constitutional, cutaneous, and haematological involvements (the frequency decreased by 0.09% for each 1-year increase). In contrast, other domains showed an ascending pattern, especially pulmonary involvement (for each 1-year increase in the age at diagnosis, the frequency of activity increased by 0.22%), and peripheral nerve involvement (the frequency increased by 0.09% for each 1-year increase). Conclusion. The influence of the age at diagnosis on the key phenotypic features of pSS is strong, and should be considered critical not only for designing a personalised diagnostic approach, but also to be carefully considered when analysing the results of diagnostic tests and immunological parameters, and when internal organ involvement is suspected at diagnosis.

Published
2021

18. Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a possible implication for therapeutic decision in these patients

Author

Ruscitti, P., Cipriani, P., Di Benedetto, P., Liakouli, V., Berardicurti, O., Carubbi, F., Ciccia, F., Alvaro, S., Triolo, G., and Giacomelli, R.

Published
2015
Full Text
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22. Erratum: Management of adult-onset Still's disease with interleukin-1 inhibitors: Evidence- And consensus-based statements by a panel of Italian experts (Arthritis Res Ther (2019) 21:275 DOI: 10.1186/s13075-019-2021-9)

Author

Colafrancesco, S., Manara, M., Bortoluzzi, A., Serban, T., Bianchi, G., Cantarini, L., Ciccia, F., Dagna, L., Govoni, M., Montecucco, C., Priori, R., Ravelli, A., Sfriso, P., Sinigaglia, L., Alivernini, S., Baldissera, E., Bartoloni, E., Berti, A., Bugatti, S., Camellino, D., Cammelli, D., Caporali, R., Caso, F., Cavallaro, E., Cavalli, G., Colaci, M., Costa, L., Di Scala, G., Emmi, G., Frassi, M., Gerli, R., Giacomelli, R., Gremese, E., Iannone, F., Lapadula, G., Leveghi, L., Lopalco, G., Manna, R., Marotto, D., Mathieu, A., Neri, R., Patisso, I., Piga, M., Punzi, L., Romano, M., Ruscitti, P., Salvarani, C., Scarpa, R., Scrivo, R., Talarico, R., Verrecchia, E., Viapiana, O., Vitale, A., Vitiello, G., Colafrancesco, S., Manara, M., Bortoluzzi, A., Serban, T., Bianchi, G., Cantarini, L., Ciccia, F., Dagna, L., Govoni, M., Montecucco, C., Priori, R., Ravelli, A., Sfriso, P., Sinigaglia, L., Alivernini, S., Baldissera, E., Bartoloni, E., Berti, A., Bugatti, S., Camellino, D., Cammelli, D., Caporali, R., Caso, F., Cavallaro, E., Cavalli, G., Colaci, M., Costa, L., Di Scala, G., Emmi, G., Frassi, M., Gerli, R., Giacomelli, R., Gremese, E., Iannone, F., Lapadula, G., Leveghi, L., Lopalco, G., Manna, R., Marotto, D., Mathieu, A., Neri, R., Patisso, I., Piga, M., Punzi, L., Romano, M., Ruscitti, P., Salvarani, C., Scarpa, R., Scrivo, R., Talarico, R., Verrecchia, E., Viapiana, O., Vitale, A., and Vitiello, G.

Abstract

Following publication of the original article [1], it was brought to our attention that the AOSD Consensus Group was incorrectly tagged and therefore not searchable. The publishers apologize for this error.

Published
2020

24. The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus

Author

Giacomelli, R. Afeltra, A. Bartoloni, E. Berardicurti, O. Bombardieri, M. Bortoluzzi, A. Carubbi, F. Caso, F. Cervera, R. Ciccia, F. Cipriani, P. Coloma-Bazán, E. Conti, F. Costa, L. D'Angelo, S. Distler, O. Feist, E. Foulquier, N. Gabini, M. Gerber, V. Gerli, R. Grembiale, R.D. Guggino, G. Hoxha, A. Iagnocco, A. Jordan, S. Kahaleh, B. Lauper, K. Liakouli, V. Lubrano, E. Margiotta, D. Naty, S. Navarini, L. Perosa, F. Perricone, C. Perricone, R. Prete, M. Pers, J.-O. Pitzalis, C. Priori, R. Rivellese, F. Ruffatti, A. Ruscitti, P. Scarpa, R. Shoenfeld, Y. Triolo, G. Tzioufas, A.

Abstract

Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. In this work, the growing body of evidence is summarized regarding the predictive factors for drug response in patients with AIDs, applying the precision medicine principles to provide high-quality evidence for therapeutic opportunities in improving the management of these patients. © 2020

Published
2021

25. Multicenter validation of the DETAIL questionnaire for the screening of spondyloarthritis in patients with inflammatory bowel diseases

Author

Benfaremo, D., Luchetti, M. M., Di Carlo, M., Salaffi, F., Gabrielli, A., Benedetti, A., Lagana, B., Picchianti-Diamanti, A., Carubbi, F., Giacomelli, R., Pica, R., Chimenti, M. S., Lorenzetti, R., Scolieri, P., Bruzzese, V., Ramonda, R., Marconi, V., Perini, L., Paci, V., Ciferri, M., Bolognini, L., Di Sario, A., Bendia, E., Mosca, P., Ribaldone, D. G., Ditto, M. C., Reumatologia, S. C., Pavlych, V., Viscido, A., Stefanelli, G., Conigliaro, P., Biancone, L., Polito, P., D'Inca, R., Navarini, L., Balestrieri, P., Serio, M., Maltoni, S., Scarcelli, A., Girolimetti, R., Frausini, G., Baccini, F., Tomietto, P., Tonello, C., Fiorani, M., and Marcasciano, R.

Subjects
Adult, medicine.medical_specialty, Immunology, Arthritis, Inflammatory bowel diseases, Likelihood ratios in diagnostic testing, Dactylitis, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Crohn Disease, Internal medicine, Fibromyalgia, Surveys and Questionnaires, Spondyloarthritis, Spondylarthritis, Back pain, medicine, Immunology and Allergy, Humans, Crohn disease, inflammatory bowel diseases, spondyloarthritis, ulcerative colitis, 030203 arthritis & rheumatology, business.industry, Enthesitis, Bayes Theorem, Ulcerative colitis, Inflammatory Bowel Diseases, medicine.disease, Settore MED/16, Cohort, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract

Objective.Spondyloarthritis (SpA) is among the most frequent extraintestinal manifestations of inflammatory bowel diseases (IBD). In this study, we aimed to validate the DETection of Arthritis in Inflammatory boweL diseases (DETAIL) questionnaire in a multicenter cohort of patients with IBD enrolled at 11 gastroenterology units.Methods.From October 2018 to March 2019, consecutive adult patients with IBD, either Crohn disease or ulcerative colitis, independently filled out the DETAIL questionnaire in the outpatient waiting room. Within 2 weeks a blinded rheumatologist assessed all the patients, irrespective of the DETAIL results, and classified them to be affected or not by SpA. The performance of the questions was evaluated through Bayesian analysis.Results.Overall, 418 patients with IBD filled out the DETAIL questionnaire. Upon rheumatological evaluation, 102 (24.4%) patients received a diagnosis of SpA. Of the 6 questions, the best performances were found in question 6 [positive likelihood ratio (LR)+ 3.77], reporting inflammatory back pain at night, and in question 3 (LR+ 3.31), exploring Achilles enthesitis. The presence of back pain lasting > 3 months (LR+ 2.91), back pain with inflammatory features (LR+ 2.55), and a history of dactylitis (LR+ 2.55), also showed a fairly good performance, whereas a history of peripheral synovitis was slightly worse (LR+ 2.16). The combination of at least 3 questions answered affirmatively yielded a posttest probability of SpA of 80% or more. The presence of alternative diagnoses, such as osteoarthritis or fibromyalgia, represented a minor confounder.Conclusion.The DETAIL questionnaire is a useful tool for the early detection of SpA in IBD.

Published
2021

26. Magnetic monopole search at high altitude with the SLIM experiment

Author

Balestra, S., Cecchini, S., Cozzi, M., Errico, M., Fabbri, F., Giacomelli, G., Giacomelli, R., Giorgini, M., Kumar, A., Manzoor, S., McDonald, J., Mandrioli, G., Marcellini, S., Margiotta, A., Medinaceli, E., Patrizii, L., Pinfold, J., Popa, V., Qureshi, I.E., Saavedra, O., Sahnoun, Z., Sirri, G., Spurio, M., Togo, V., Velarde, A., and Zanini, A.

Published
2008
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27. SARS-CoV-2 infection in patients with primary Sjögren syndrome: characterization and outcomes of 51 patients

Author

Brito-Zerón, Pilar, Melchor, Sheila, Seror, Raphaèle, Priori, Roberta, Solans, Roser, Kostov, Belchin, Baldini, Chiara, Carubbi, Francesco, Callejas, Jose Luis, Guisado-Vasco, Pablo, Hernández-Molina, Gabriela, Pasoto, Sandra G, Valim, Valeria, Sisó-Almirall, Antoni, Mariette, Xavier, Carreira, Patricia, Ramos-Casals, Manuel, Brito-Zerón, P, Morcillo, C, Flores-Chávez, A, Ramos-Casals, M, Acar-Denizli, N, Horvath, I F, Szanto, A, Tarr, T, Seror, R, Mariette, X, Mandl, T, Olsson, P, Li, X, Xu, B, Baldini, C, Bombardieri, S, Gottenberg, J E, Gandolfo, S, De Vita, S, Priori, R, Giardina, F, Hernandez-Molina, G, Sánchez-Guerrero, J, Kruize, A A, Hinrichs, A, Valim, V, Isenberg, D, Solans, R, Rischmueller, M, Downie-Doyle, S, Kwok, S-K, Park, S-H, Nordmark, G, Suzuki, Y, Kawano, M, Giacomelli, R, Devauchelle-Pensec, V, Saraux, A, Hofauer, B, Knopf, A, Bootsma, H, Vissink, A, Morel, J, Vollenveider, C, Atzeni, F, Retamozo, S, Moça Trevisano, V, Armagan, B, Kilic, L, Kalyoncu, U, Pasoto, S G, Kostov, B, Sisó-Almirall, A, Consani-Fernández, S, Carubbi, F, Callejas, J L, López-Dupla, M, Pérez-Alvarez, R, Akasbi, M, Guisado-Vasco, P, Sánchez, I, Hospital Universitario 12 de Octubre [Madrid], EULAR standing committee of People with Arthritis/Rheumatism in Europe (PARE), H. CIMA-Sanitas, Barcelona, CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, Instituto Mexicano del Seguro Social [Mexico City, Mexico] (IMSS), Universidad de Colima [Mexico], Hospital Clinic [Barcelona, Spain], İstanbul Üniversitesi, İstanbul, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary, MTA-Debreceni Egyetem, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, Skåne University Hospital [Malmö, Suède], Stockholm University, Wuhan University [China], Pisa University Hospital, Nuclear Medicine Unit, Humanitas Gavazzeni, Bergamo, Italy, University Hospitals, Strasbourg, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Federal University of Espírito Santo, University Hospital Vall d’Hebròn [Barcelona, Spain], Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut d'Investigaciones Biomèdiques August Pi i Sunye (IDIBAPS), Università degli studi di Palermo - University of Palermo, Hospitales Universitarios de Granada/Universidad de Granada, Hospital Universitario Quironsalud, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Rheumatology Unit, Department of Internal Medicine, University of Palermo, Palermo, Italy, and Michel, Geneviève

Subjects
Male, medicine.medical_specialty, Multivariate analysis, [SDV.IMM] Life Sciences [q-bio]/Immunology, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Comorbidity, Laboratory abnormality, comorbidities, outcomes, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Risk Factors, Internal medicine, medicine, Humans, In patient, Pharmacology (medical), 030212 general & internal medicine, Registries, Risk factor, Primary Sjögren Syndrome, AcademicSubjects/MED00360, ComputingMilieux_MISCELLANEOUS, 030203 arthritis & rheumatology, business.industry, SARS-CoV-2, COVID-19, Primary SS, SARS-Cov-2, Middle Aged, medicine.disease, 3. Good health, Hospitalization, Sjogren's Syndrome, [SDV.IMM]Life Sciences [q-bio]/Immunology, Original Article, Female, business
Abstract

Objective To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS. Methods We searched for patients with primary SS presenting with SARS-CoV-2 infection (defined following and according to the European Centre for Disease Prevention and Control guidelines) among those included in the Big Data Sjögren Registry, an international, multicentre registry of patients diagnosed according to the 2002/2016 classification criteria. Results A total of 51 patients were included in the study (46 women, mean age at diagnosis of infection of 60 years). According to the number of patients with primary SS evaluated in the Registry (n = 8211), the estimated frequency of SARS-CoV-2 infection was 0.62% (95% CI 0.44, 0.80). All but two presented with symptoms suggestive of COVID-19, including fever (82%), cough (57%), dyspnoea (39%), fatigue/myalgias (27%) and diarrhoea (24%), and the most frequent abnormalities included raised lactate dehydrogenase (LDH) (88%), CRP (81%) and D-dimer (82%) values, and lymphopenia (70%). Infection was managed at home in 26 (51%) cases and 25 (49%) required hospitalization (five required admission to ICU, four died). Compared with patients managed at home, those requiring hospitalization had higher odds of having lymphopenia as laboratory abnormality (adjusted OR 21.22, 95% CI 2.39, 524.09). Patients with comorbidities had an older age (adjusted OR 1.05, 95% CI 1.00, 1.11) and showed a risk for hospital admission six times higher than those without (adjusted OR 6.01, 95% CI 1.72, 23.51) in the multivariate analysis. Conclusion Baseline comorbidities were a key risk factor for a more complicated COVID-19 in patients with primary SS, with higher rates of hospitalization and poor outcomes in comparison with patients without comorbidities.

Published
2020
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31. AB1632 PREVALENCE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT THE REFERRAL CENTERS IN ITALY: A MULTICENTER STUDY

Author

Mattioli, I., Bettiol, A., Doria, A., Zen, M., Govoni, M., Bortoluzzi, A., Franceschini, F., Fredi, M., Mosca, M., Tani, C., Sebastiani, G.D., Orefice, V., Giacomelli, R., Vadacca, M., D'agostino, M.A., Bosello, S.L., Bergamini, A., Conigliaro, P., Conti, F., Spinelli, F.R., De Paulis, A., Mormile, I., Ciccia, F., Fasano, S., Iannone, F., Coladonato, L., Vacca, A., Noviello, S., Piga, M., Chessa, E., De Marchi, G., Luca, Q., Silvestri, E., and Emmi, G.

Published
2023
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33. AB0431 CANAKINUMAB AS FIRST-LINE BIOLOGICAL THERAPY IN STILL'S DISEASE AND DIFFERENCES BETWEEN THE SYSTEMIC AND THE CHRONIC-ARTICULAR COURSES: REAL-LIFE EXPERIENCE FROM THE INTERNATIONAL AIDA REGISTRY

Author

Vitale, A., Caggiano, V., Maggio, M.C., Lopalco, G., Emmi, G., Sota, J., La Torre, F., Ruscitti, P., Bartoloni, E., Conti, G., Fabiani, C., Mattioli, I., Gaggiano, C., Cardinale, F., Dagna, L., Campochiaro, C., Giacomelli, R., Balistreri, A., Laskari, K., Tufan, A., Ragab, G., Almaghlouth, I., Więsik-Szewczyk, E., Pereira, R.M., Frediani, B., Iannone, F., Sfikakis, P., and Cantarini, L.

Published
2023
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36. Italian recommendations for influenza and pneumococcal vaccination in adult patients with autoimmune rheumatic diseases

Author

Guerrini, G., Franzetti, F., Giacomelli, R., Meroni, L., Riva, A., Scirè, C. A., Scrivo, R., Tavio, M., Agostinone, A., Airò, P., Atzeni, F., Bartalesi, F., Bazzichi, L., Berardicurti, O., Cassola, G., antonella castagna, Castelli, F., Cattelan, A., Citriniti, G., Cristini, F., Rosa, F., Fracassi, E., Galloway, J., La Paglia, G. M. C., Moioli, M. C., Ripamonti, D., Saracino, A., Tani, C., Tascini, C., Tieghi, T., Tinelli, M., Zabotti, A., Sarzi-Puttini, P., Galli, M., Guerrini, G, Franzetti, F, Giacomelli, R, Meroni, L, Riva, A, Scire, C, Scrivo, R, Tavio, M, Agostinone, A, Airo, P, Atzeni, F, Bartalesi, F, Bazzichi, L, Berardicurti, O, Cassola, G, Castagna, A, Castelli, F, Cattelan, A, Citriniti, G, Cristini, F, De Rosa, F, Fracassi, E, Galloway, J, La Paglia, G, Moioli, M, Ripamonti, D, Saracino, A, Tani, C, Tascini, C, Tieghi, T, Tinelli, M, Zabotti, A, Sarzi-Puttini, P, Galli, M, Guerrini, Giulio, Franzetti, Fabio, Giacomelli, Roberto, Meroni, Luca, Riva, Agostino, Scirè, Carlo Alberto, Scrivo, Rossana, Tavio, Marcello, Agostinone, Adriana, Airò, Paolo, Atzeni, Fabiola, Bartalesi, Filippo, Bazzichi, Laura, Berardicurti, Onorina, Cassola, Giovanni, Castagna, Antonella, Castelli, Francesco, Cattelan, Annamaria, Citriniti, Giorgia, Cristini, Francesco, De Rosa, Francesco, Fracassi, Elena, Galloway, Jame, La Paglia, Giuliana Maria Concetta, Moioli, Maria Cristina, Ripamonti, Diego, Saracino, Annalisa, Tani, Chiara, Tascini, Carlo, Tieghi, Tiziana, Tinelli, Marco, Zabotti, Alen, Sarzi-Puttini, Piercarlo, and Galli, Massimo

Subjects
Adult, Male, pneumococcal vaccine, Consensus, infuenza vaccine, Immunology, vaccination, autoimmune disease, NO, recommendations, influenza vaccination, pneumococcal vaccination, autoimmune rheumatic diseases, Autoimmune Diseases, Pneumococcal Vaccines, Rheumatology, Rheumatic Diseases, Influenza, Human, Pneumonia, Staphylococcal, Immunology and Allergy, Humans, disease-modifying anti-rheumatic drugs, Evidence-Based Medicine, Vaccination, Pneumonia, Influenza, disease-modifying anti-rheumatic drugs, autoimmune rheumatic diseases, infuenza vaccine, pneumococcal vaccine, Italy, Influenza Vaccines, Staphylococcal, Female, Immunosuppressive Agents, Human
Abstract

OBJECTIVES: To provide evidence-based recommendations for vaccination against influenza virus and S. pneumoniae in patients with autoimmune rheumatic diseases (ARDs). METHODS: A Consensus Committee including physicians with expertise in rheumatic and infectious diseases was established by two Italian scientific societies, Società Italiana di Reumatologia (SIR) and Società Italiana di Malattie Infettive e Tropicali (SIMIT). The experts were invited to develop evidence-based recommendations concerning vaccinations in ARDs patients, based on their clinical status before and after undergoing immunosuppressive treatments. Key clinical questions were formulated for the systematic literature reviews, based on the clinical pathway. A search was made in Medline (via PubMed) according to the original MeSH strategy from October 2009 and a keyword strategy from January 2016 up to December 2017, updating existing EULAR recommendations. Specific recommendations were separately voted and scored from 0 (no agreement with) to 100 (maximal agreement) and supporting evidence graded. The mean and standard deviation of the scores were calculated to determine the level of agreement among the experts' panel for each recommendation. Total cumulative agreement ≥70 defined consensus for each statement. RESULTS: Nine recommendations, based on 6 key clinical questions addressed by the expert committee, were proposed. The aim of this work is to integrate the 2011 EULAR recommendations on vaccination against influenza and S. pneumoniae in ARDs patients. An implementation plan was proposed to improve the vaccination status of these patients and their safety during immunosuppressive treatments. CONCLUSIONS: Influenza and pneumococcus vaccinations are effective and safe in patients with ARDs. More efforts should be made to translate the accumulated evidence into practice.

Published
2019

37. Measurement and interpretation of differential cross sections for Higgs boson production at root s=13 TeV

Author

Sirunyan, A. M., Tumasyan, A., Adam, W., Ambrogi, F., Asilar, E., Bergauer, T., Brandstetter, J., Dragicevic, M., Ero, J., Escalante Del Valle, A., Flechl, M., Fruhwirth, R., Ghete, V. M., Hrubec, J., Jeitler, M., Krammer, N., Kratschmer, I., Liko, D., Madlener, T., Mikulec, I., Rad, N., Rohringer, H., Schieck, J., Schofbeck, R., Spanring, M., Spitzbart, D., Taurok, A., Waltenberger, W., Wittmann, J., Wulz, C. -E., Zarucki, M., Chekhovsky, V., Mossolov, V., Gonzalez, J. Suarez, De Wolf, E. A., Di Croce, D., Janssen, X., Lauwers, J., Pieters, M., Van Haevermaet, H., Van Mechelen, R., Van Remortel, N., Abu Zeid, S., Blekman, F., D'Hondt, J., De Clercq, J., Deroover, K., Flouris, G., Lontkovskyi, D., Lowette, S., Marchesini, I., Moortgat, S., Moreels, L., Python, Q., Skovpen, K., Tavernier, S., Van Doninck, W., Van Mulders, R., Van Parijs, I., Beghin, D., Bilin, B., Brun, H., Clerbaux, B., De Lentdecker, G., Delannoy, H., Dorney, B., Fasanella, G., Favart, L., Goldouzian, R., Grebenyuk, A., Kalsi, A. K., Lenzi, T., Luetic, J., Postiau, N., Starling, E., Thomas, L., Vander Velde, C., Vanlaer, R., Vannerom, D., Wang, Q., Cornelis, T., Dobur, D., Fagot, A., Gul, M., Khvastunov, I., Poyraz, D., Roskas, C., Trocino, D., Tytgat, M., Verbeke, W., Vermassen, B., Vit, M., Zaganidis, N., Bakhshiansohi, H., Bondu, O., Brochet, S., Bruno, G., Caputo, C., David, R., Delaere, C., Delcourt, M., Giammanco, A., Krintiras, G., Lemaitre, V., Magitteri, A., Piotrzkowski, K., Saggio, A., Vidal Marono, M., Wertz, S., Zobec, J., Alves, F. L., Alves, G. A., Correa Martins Junior, M., Silva, G. Correia, Hensel, C., Moraes, A., Pol, M. E., Rebello Teles, R., Belchior Batista Das Chagas, E., Carvalho, W., Chinellato, J., Coelho, E., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., De Oliveira Martins, C., Fonseca De Souza, S., Malbouisson, H., Matos Figueiredo, D., Melo De Almeida, M., Mora Herrera, C., Mundim, L., Nogima, H., Prado Da Silva, W. L., Sanchez Rosas, L. J., Sznajder, A., Thiel, M., Santoro, A., Tonelli Manganote, E. J., Torres Da Silva De Araujo, F., Pereira, A. Vilela, Ahuja, S., Bernardes, C. A., Calligaris, L., Fernandez Perez Tomei, T. R., Gregores, E. M., Mercadante, P. G., Novaes, S. F., Padul, S. S., Aleksandrov, A., Hadjiiska, R., Iaydjiev, R., Marinov, A., Misheva, M., Rodozov, M., Shopova, M., Sultanov, G., Dimitrov, A., Litov, L., Pavlov, B., Petkov, P., Fang, W., Gao, X., Yuan, L., Ahmad, M., Bian, J. G., Chen, G. M., Chen, H. S., Chen, M., Chen, Y., Jiang, C. H., Leggat, D., Liao, H., Liu, Z., Romeo, F., Shaheen, S. M., Spiezia, A., Tao, J., Wang, Z., Yazgan, E., Zhang, H., Zhang, S., Zhao, J., Ban, Y., Chen, G., Levin, A., Li, J., Li, L., Li, Q., Mao, Y., Qian, S. J., Wang, D., Wang, Y., Avila, C., Cabrera, A., Carrillo Montoya, C. A., Chaparro Sierra, L. F., Florez, C., Gonzalez Hernandez, C. F., Segura Delgado, M. A., Courbon, B., Godinovic, N., Lelas, D., Puljak, I., Sculac, T., Antunovic, Z., Kovac, M., Brigljevic, V., Ferencek, D., Kadija, K., Mesic, B., Starodumov, A., Susa, T., Ather, M. W., Attikis, A., Kolosova, M., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Finger, M., Finger M., Jr., Ayala, E., Jarrin, E. Carrera, Abdalla, H., Abdelalim, A. A., Mohamed, A., Bhowmik, S., Antunes De Oliveira, A. Carvalho, Dewanjee, R. K., Ehataht, K., Kadastik, M., Raidal, M., Veelken, C., Eerola, P., Kirschenmann, H., Pekkanen, J., Voutilainen, M., Havukainen, J., Heikkila, J. K., Jarvinen, T., Karimaki, V., Kinnunen, R., Lampen, T., Lassila-Perini, K., Laurila, S., Lehti, S., Linden, T., Luukka, R., Maenpaa, T., Siikonen, H., Tuominen, E., Tuominiemi, J., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Faure, J. L., Ferri, F., Ganjour, S., Givernaud, A., Gras, R., De Monchenault, G. Hamel, Jarry, R., Leloup, C., Locci, E., Malcles, J., Negro, G., Rander, J., Rosowsky, A., Sahin, M. O., Titov, M., Abdulsalam, A., Amendola, C., Antropov, I., Beaudette, F., Busson, R., Chariot, C., De Cassagnac, R. Granier, Kucher, I., Lobanov, A., Blanco, J. Martin, Perez, C. Martin, Nguyen, M., Ochando, C., Ortona, G., Paganini, R., Pigard, R., Rembser, J., Salerno, R., Sauvan, J. B., Sirois, Y., Leiton, A. G. Stahl, Zabi, A., Zghiche, A., Agram, J. -L., Andrea, J., Bloch, D., Brom, J. -M., Chabert, E. C., Cherepanov, V., Collard, C., Conte, E., Fontaine, J. -C., Gele, D., Goerlach, U., Jansova, M., Le Bihan, A. -C., Tonon, N., Van Hove, R., Gadrat, S., Beauceron, S., Bernet, C., Boudoul, G., Chanon, N., Chierici, R., Contardo, D., Depasse, R., El Mamouni, H., Fay, J., Finco, L., Gascon, S., Gouzevitch, M., Grenier, G., Ille, B., Lagarde, F., Laktineh, I. B., Lattaud, H., Lethuillier, M., Mirabito, L., Perries, S., Popov, A., Sordini, V., Touquet, G., Donckt, M. Vander, Viret, S., Khvedelidze, A., Tsamalaidze, Z., Autermann, C., Feld, L., Kiesel, M. K., Klein, K., Lipinski, M., Preuten, M., Rauch, M. P., Schomakers, C., Schulz, J., Teroerde, M., Wittmer, B., Albert, A., Duchardt, D., Erdmann, M., Erdweg, S., Esch, T., Fischer, R., Ghosh, S., Gueth, A., Hebbeker, T., Heidemann, C., Hoepfner, K., Keller, H., Mastrolorenzo, L., Merschmeyer, M., Meyer, A., Millet, R., Mukherjee, S., Pook, T., Radziej, M., Reithler, H., Rieger, M., Schmidt, A., Teyssier, D., Thueer, S., Fluegge, G., Hlushchenko, V., Kress, T., Mueller, T., Nehrkorn, A., Nowack, A., Pistone, C., Pooth, Y., Roy, D., Sert, H., Stahl, A., Martin, M. Aldaya, Arndt, T., Asawatangtrakuldee, C., Babounikau, I., Beernaert, K., Behnke, O., Behrens, U., Martinez, A. Bermudez, Bertsche, D., Bin Anuar, A. A., Borras, K., Botta, V., Campbell, A., Connor, R., Contreras-Campana, C., Danilov, V., De Wit, A., Defranchis, M. M., Pardos, C. Diez, Damiani, D. 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Subjects
Science & Technology, hep-ex, Higgs boson coupling modifiers, High Energy Physics::Lattice, Physics, High Energy Physics::Phenomenology, Astronomy & Astrophysics, MASS, Nuclear & Particles Physics, Physics, Particles & Fields, Differential cross sections, Combination, Physics, Nuclear, Physics and Astronomy, Physical Sciences, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, High Energy Physics::Experiment, Nuclear Experiment
Abstract

Made available in DSpace on 2019-10-06T00:34:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-05-10 FWF FNRS FWO (Belgium) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) FAPERGS Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) MES (Bulgaria) MOST NSFC (China) COLCIENCIAS (Colombia) CSF (Croatia) SENESCYT (Ecuador) MoER ERDF (Estonia) Academy of Finland MEC CEA CNRS/IN2P3 (France) BMBF DFG HGF (Germany) GSRT (Greece) NKFIA (Hungary) DAE DST IPM SFI (Ireland) INFN (Italy) NRF (Republic of Korea) MES (Latvia) MOE and UM (Malaysia) BUAP CONACYT (UASLP-FAI Mexico) MBIE (New Zealand) PAEC (Pakistan) MSHE FCT (Portugal) JINR (Dubna) RFBR MESTD (Serbia) SEIDI FEDER (Spain) Swiss Funding Agencies (Switzerland) NSTDA TUBITAK TAEK NASU DOE NSF Marie-Curie programme European Research Council Horizon 2020 Grant A. G. Leventis Foundation Alfred P. Sloan Foundation Alexander von Humboldt Foundation Belgian Federal Science Policy Office Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium) FWO (Belgium) under the Excellence of Science - EOS Ministry of Education, Youth and Sports (MEYS) of the Czech Republic Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences Council of Science and Industrial Research, India HOMING PLUS programme of the Foundation for Polish Science European Union, Regional Development Fund National Science Centre(Poland) Sonata-bis National Priorities Research Program by Qatar National Research Fund Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu Programa Severo Ochoa del Principado de Asturias Thalis EU-ESF Greek NSRF Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University Welch Foundation Weston Havens Foundation (USA) Differential Higgs boson (H) production cross sections are sensitive probes for physics beyond the standard model. New physics may contribute in the gluon-gluon fusion loop, the dominant Higgs boson production mechanism at the LHC, and manifest itself through deviations from the distributions predicted by the standard model. Combined spectra for the H -> gamma gamma, H -> ZZ, and H -> b (b) over bar decay channels and the inclusive Higgs boson production cross section are presented, based on proton-proton collision data recorded with the CMS detector at root s = 13 TeV corresponding to an integrated luminosity of 35.9 fb(-1). The transverse momentum spectrum is used to place limits on the Higgs boson couplings to the top, bottom, and charm quarks, as well as its direct coupling to the gluon field. No significant deviations from the standard model are observed in any differential distribution. The measured total cross section is 61.1 +/- 6.0 (stat) +/- 3.7 (syst) pb, and the precision of the measurement of the differential cross section of the Higgs boson transverse momentum is improved by about 15% with respect to the H -> gamma gamma channel alone. (C) 2019 The Author(s). Published by Elsevier B.V. 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Italy Univ Bari, Bari, Italy Politecn Bari, Bari, Italy INFN, Sez Bologna, Bologna, Italy Univ Bologna, Bologna, Italy INFN, Sez Catania, Catania, Italy Univ Catania, Catania, Italy INFN, Sez Firenze, Florence, Italy Univ Firenze, Florence, Italy INFN Lab Nazl Frascati, Frascati, Italy INFN, Sez Genova, Genoa, Italy Univ Genoa, Genoa, Italy INFN, Sez Milano Bicocca, Milan, Italy Univ Milano Bicocca, Milan, Italy INFN, Sez Napoli, Naples, Italy Univ Napoli Federico 11, Naples, Italy Univ Basilicata, Potenza, Italy Univ G Marconi, Rome, Italy INFN, Sez Padova, Padua, Italy Univ Padua, Padua, Italy Univ Trento, Trento, Italy INFN, Sez Pavia, Pavia, Italy Univ Pavia, Pavia, Italy INFN, Sez Perugia, Perugia, Italy Univ Perugia, Perugia, Italy INFN, Sez Pisa, Pisa, Italy Univ Pisa, Pisa, Italy Scuola Normale Super Pisa, Pisa, Italy INFN, Sez Roma, Rome, Italy Sapienza Univ Roma, Rome, Italy INFN, Sez Torino, Turin, Italy Univ Torino, Turin, Italy Univ Piemonte Orientale, Novara, Italy INFN, 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Portugal Joint Inst Nucl Res, Dubna, Russia Petersburg Nucl Phys Inst, St Petersburg, Russia Inst Nucl Res, Moscow, Russia Inst Theoret & Expt Phys, Moscow, Russia Moscow Inst Phys & Technol, Moscow, Russia Natl Res Nucl Univ Moscow Engn Phys Inst MEPhI, Moscow, Russia PN Lebedev Phys Inst, Moscow, Russia Lomonosov Moscow State Univ, Skobeltsyn Inst Nucl Phys, Moscow, Russia NSU, Novosibirsk, Russia Inst High Energy Phys Natl Res Ctr, Kurchatov Inst, Protvino, Russia Natl Res Tomsk Polytech Univ, Tomsk, Russia Univ Belgrade, Fac Phys, Belgrade, Serbia Vinca Inst Nucl Sci, Belgrade, Serbia Ctr Invest Energet Medioambient & Tecnol CIEMAT, Madrid, Spain Univ Autonoma Madrid, Madrid, Spain Univ Oviedo, Oviedo, Spain Univ Cantabria, CSIC, Inst Fis Cantabria IFCA, Santander, Spain Univ Ruhuna, Dept Phys, Matara, Sri Lanka European Org Nucl Res, CERN, Geneva, Switzerland Paul Scherrer Inst, Villigen, Switzerland Swiss Fed Inst Technol, Inst Particle Phys & Astrophys IPA, Zurich, Switzerland Univ Zdrich, Zurich, Switzerland Natl Cent Univ, Chungli, Taiwan NTU, Taipei, Taiwan Chulalongkorn Univ, Dept Phys, Fac Sci, Bangkok, Thailand Cukurova Univ, Sci & Art Fac, Phys Dept, Adana, Turkey Middle Tech Univ, Phys Dept, Ankara, Turkey Bogazici Univ, Istanbul, Turkey Istanbul Tech Univ, Istanbul, Turkey Natl Acad Sci Ukraine, Inst Scintillat Mat, Kharkov, Ukraine Natl Sci Ctr, Kharkov Inst Phys & Technol, Kharkov, Ukraine Univ Bristol, Bristol, Avon, England Rutherford Appleton Lab, Didcot, Oxon, England Imperial Coll, London, England Brunel Univ, Uxbridge, Middx, England Baylor Univ, Waco, TX 76798 USA Catholic Univ Amer, Washington, DC 20064 USA Univ Alabama, Tuscaloosa, AL USA Boston Univ, Boston, MA 02215 USA Brown Univ, Providence, RI 02912 USA Univ Calif Davis, Davis, CA 95616 USA Univ Calif Los Angeles, Los Angeles, CA USA Univ Calif Riverside, Riverside, CA 92521 USA Univ Calif San Diego, La Jolla, CA 92093 USA Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 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Univ, Adiyaman, Turkey Ozyegin Univ, Istanbul, Turkey Izmir Inst Technol, Izmir, Turkey Marmara Univ, Istanbul, Turkey Kafkas Univ, Kars, Turkey Istanbul Univ, Fac Sci, Istanbul, Turkey Istanbul Bilgi Univ, Istanbul, Turkey Hacettepe Univ, Ankara, Turkey Univ Southampton, Sch Phys & Astron, Southampton, Hants, England Monash Univ, Fac Sci, Clayton, Vic, Australia Bethel Univ, St Paul, MN USA Karamanoglu Mehmetbey Univ, Karaman, Turkey Utah Valley Univ, Orem, MA USA Beykent Univ, Istanbul, Turkey Bingol Univ, Bingol, Turkey Sinop Univ, Sinop, Turkey Mimar Sinan Univ, Istanbul, Turkey Texas A&M Univ, Doha, Qatar Univ Estadual Paulista, Sao Paulo, Brazil Horizon 2020 Grant: 675440 FWO (Belgium) under the Excellence of Science - EOS: 30820817 Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences: 123842 Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences: 123959 Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences: 124845 Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences: 124850 Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences: 125105 National Science Centre(Poland): Harmonia 2014/14/M/ST2/00428 National Science Centre(Poland): 2014/13/B/ST2/02543 National Science Centre(Poland): 2014/15/B/ST2/03998 National Science Centre(Poland): 2015/19/B/ST2/02861 Sonata-bis: 2012/07/E/ST2/01406 Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu: MDM-2015-0509 Welch Foundation: C-1845

Published
2019

38. Vitamin D increases the production of IL-10 by regulatory T cells in patients with systemic sclerosis

Author

Di Liberto, D., concetta scazzone, La Rocca, G., Cipriani, P., Lo Pizzo, M., Ruscitti, P., Agnello, L., Ciaccio, M., Dieli, F., Giacomelli, R., Triolo, G., Ciccia, F., Sireci, G., Guggino, G., Di Liberto D., Scazzone C., La Rocca G., Cipriani P., Lo Pizzo M., Ruscitti P., Agnello L., Ciaccio M., Dieli F., Giacomelli R., Triolo G., Ciccia F., Sireci G., Guggino G., Di Liberto, Diana, Scazzone, Concetta, La Rocca, Gaetano, Cipriani, Paola, Lo Pizzo, Marianna, Ruscitti, Piero, Agnello, Luisa, Ciaccio, Marcello, Dieli, Francesco, Giacomelli, Roberto, Triolo, Giovanni, Ciccia, Francesco, Sireci, Guido, and Guggino, Giuliana

Subjects
Male, Scleroderma, Systemic, Middle Aged, T-Lymphocytes, Regulatory, Interleukin-10, Case-Control Studies, Dietary Supplements, Leukocytes, Mononuclear, Humans, Female, Vitamin D, systemic sclerosis, vitamin D, Tregs, Case-Control Studie, Dietary Supplement, Human
Abstract

OBJECTIVES: Vitamin D status influences the risk to develop autoimmune diseases affecting the percentage and/or functions of regulatory T cells (Tregs). Since low levels of 25 (OH) D have been decreased in patients with systemic sclerosis (SSc), we aimed to study the effect of Vitamin D3 (cholecalciferol) supplementation on Tregs frequencies and functions. METHODS: Peripheral blood and sera samples were obtained from 45 SSc patients and controls (HC). A number of eighteen SSc patients had consumed Cholecalciferol (orally) at the dose of 25.000 UI/month for 6 months at the time of enrollment. 25(OH)D serum levels were measured and VDR polymorphisms, were genotyped by polymerase chain reaction (PCR). Tregs isolated from peripheral blood mononuclear cells were in vitro expanded and a suppression assay was performed. Flow cytometry analysis was then carried out. Finally, IL-10 production was assayed by ELISA. RESULTS: Low serum levels of 25(OH)D were detected in SSc patients. The percentage of Tregs in SSc patients was similar to controls, but, among SSc patients, it was higher in those patients taking cholecalciferol. Tregs capability to suppress T cell proliferation was impaired in SSc patients and not restored after in vitro pre-treatment with the active form of Vitamin D (1,25(OH)2D3); but at the same time the production of IL-10 was increased in treated samples obtained from patients. The lack of response of Tregs from SSc patients to 1,25(OH)2D3 treatment in vitro was not due to altered Vitamin D/VDR signalling. CONCLUSIONS: Altogether, our results indicate that the increased production of IL-10 by 1,25(OH)2D3 -treated Tregs could provide a "suppressive" cytokine milieu able to modulate immune response but it is not sufficient to restore the immune suppressive functions of Tregs.

Published
2019

39. Determination of the production rate of D*0 mesons and of the ratio V/(V+P) in \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$Z^0 \to c\bar c$$ \end{document} decays

Author

Ackerstaff, K., Alexander, G., Allison, J., Altekamp, N., Anderson, K. J., Anderson, S., Arcelli, S., Asai, S., Ashby, S. F., Axen, D., Azuelos, G., Ball, A. H., Barberio, E., Barlow, R. J., Bartoldus, R., Batley, J. R., Baumann, S., Bechtluft, J., Behnke, T., Bell, K. W., Bella, G., Bentvelsen, S., Bethke, S., Betts, S., Biebel, O., Biguzzi, A., Bird, S. D., Blobel, V., Bloodworth, I. J., Bobinski, M., Bock, P., Bonacorsi, D., Boutemeur, M., Braibant, S., Brigliadori, L., Brown, R. M., Burckhart, H. J., Burgard, C., Bürgin, R., Capiluppi, P., Carnegie, R. K., Carter, A. A., R.Carter, J., Chang, C. Y., Charlton, D. G., Chrisman, D., Clarke, P. E. L., Cohen, I., Conboy, J. E., Cooke, O. C., Couyoumtzelis, C., Coxe, R. L., Cuffiani, M., Dado, S., Dallapiccola, C., Dallavalle, G. M., Davis, R., Jong, S. De, del Pozo, L. A., de Roeck, A., Desch, K., Dienes, B., Dixit, M. S., Doucet, M., Duchovni, E., Duckeck, G., Duerdoth, I. P., Eatough, D., Estabrooks, P. G., Etzion, E., Evans, H. G., Evans, M., Fabbri, F., Fanfani, A., Fanti, M., Faust, A. A., Feld, L., Fiedler, F., Fierro, M., Fischer, H. M., Fleck, I., Folman, R., Fong, D. G., Foucher, M., Fürtjes, A., Futyan, D. I., Gagnon, P., Gary, J. W., Gascon, J., Gascon-Shotkin, S. M., Geddes, N. I., Geich-Gimbel, C., Geralis, T., Giacomelli, G., Giacomelli, P., Giacomelli, R., Gibson, V., Gibson, W. R., Gingrich, D. M., Glenzinski, D., Goldberg, J., Goodrick, M. J., Gorn, W., Grandi, C., Gross, E., Grunhaus, J., Gruwé, M., Hajdu, C., Hanson, G. G., Hansroul, M., Hapke, M., Hargrove, C. K., Hart, P. A., Hartmann, C., Hauschild, M., Hawkes, C. M., Hawkings, R., Hemingway, R. J., Herndon, M., Herten, G., Heuer, R. D., Hildreth, M. D., Hill, J. C., Hillier, S. J., Hobson, P. R., Hocker, A., Homer, R. J., Honma, A. K., Horvath, D., Hossain, K. R., Howard, R., Hüntemeyer, P., Hutchcroft, D. E., Igo-Kemenes, P., Imrie, D. C., Ishii, K., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Joly, A., Jones, C. R., Jones, M., Jost, U., Jovanovic, P., Junk, T. R., Kanzaki, J., Karlen, D., Kartvelishvili, V., Kawagoe, K., Kawamoto, T., Kayal, P. I., Keeler, R. K., Kellogg, R. G., Kennedy, B. W., Kirk, J., Klier, A., Kluth, S., Kobayashi, T., Kobel, M., Koetke, D. S., Kokott, T. P., Kolrep, M., Komamiya, S., Kowalewski, R. V., Kress, T., Krieger, P., von Krogh, J., Kyberd, P., Lafferty, G. D., Lahmann, R., Lai, W. P., Lanske, D., Lauber, J., Lautenschlager, S. R., Lawson, I., Layter, J. G., Lazic, D., Lee, A. M., Lefebvre, E., Lellouch, D., Letts, J., Levinson, L., List, B., Lloyd, S. L., Loebinger, F. K., Long, G. D., Losty, M. J., Ludwig, J., Lui, D., Macchiolo, A., Macpherson, A., Mannelli, M., Marcellini, S., Markopoulos, C., Markus, C., Martin, A. J., Martin, J. P., Martinez, G., Mashimo, T., Mättig, P., McDonald, W. J., McKenna, J., Mckigney, E. A., McMahon, T. J., McPherson, R. A., Meijers, F., Menke, S., Merritt, F. S., Mes, H., Meyer, J., Michelini, A., Mihara, S., Mikenberg, G., Miller, D. J., Mincer, A., Mir, R., Mohr, W., Montanari, A., Mori, T., Mihara, S., Nagai, K., Nakamura, I., Neal, H. A., Nellen, B., Nisius, R., O’Neale, S. W., Oakham, F. G., Odorici, F., Ogren, H. O., Oh, A., Oldershaw, N. J., Oreglia, M. J., Orito, S., Pálinkás, J., Pásztor, G., Pater, J. R., Patrick, G. N., Patt, J., Perez-Ochoa, R., Petzold, S., Pfeifenschneider, P., Pilcher, J. E., Pinfold, J., Plane, D. E., Poffenberger, P., Poli, B., Posthaus, A., Rembser, C., Robertson, S., Robins, S. A., Rodning, N., Roney, J. M., Rooke, A., Rossi, A. M., Routenburg, P., Rozen, Y., Runge, K., Runolfsson, O., Ruppel, U., Rust, D. R., Sachs, K., Saeki, T., Sahr, O., Sang, W. M., Sarkisyan, E. K. G., Sbarra, C., Schaile, A. D., Schaile, O., Scharf, F., Scharff-Hansen, P., Schieck, J., Schleper, P., Schmitt, B., Schmitt, S., Schöming, A., Schröder, M., Schumacher, M., Schwick, C., Scott, W. G., Shears, T. G., Shen, B. C., Shepherd-Themistocleous, C. H., Sherwood, P., Siroli, G. P., Sittler, A., Skillman, A., Skuja, A., Smith, A. M., Snow, G. A., Sobie, R., Söldner-Rembold, S., Springer, R. W., Sproston, M., Stephens, K., Steuerer, J., Stockhausen, B., Stoll, K., Strom, D., Ströhmer, R., Szymanski, P., Tafirout, R., Talbot, S. D., Taras, P., Tarem, S., Teuscher, R., Thiergen, M., Thomson, M. A., von Törne, E., Torrence, E., Towers, S., Trigger, I., Trócsányi, Z., Tsur, E., Turcot, A. S., Turner-Watson, M. F., Ueda, I., Utzat, P., Van Kooten, R., Vannerem, P., Verzocchi, M., Vikas, P., Vokurka, E. H., Voss, H., Wäckerle, F., Wagner, A., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Wells, P. S., Wermes, N., White, J. S., Wilson, G. W., Wilson, J. A., Wyatt, T. R., Yamashita, S., Yekutieli, G., Zacek, V., and Zer-Zion, D.

Published
1998
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41. A search for neutral Higgs bosons in the MSSM and models with two scalar field doublets

Author

Ackerstaff, K., Alexander, G., Allison, J., Altekamp, N., Anderson, K. J., Anderson, S., Arcelli, S., Asai, S., Ashby, S. F., Axen, D., Azuelos, G., Ball, A. H., Barberio, E., Barlow, R. J., Bartoldus, R., Batley, J. R., Baumann, S., Bechtluft, J., Behnke, T., Bell, K. W., Bella, G., Bentvelsen, S., Bethke, S., Betts, S., Biebel, O., Biguzzi, A., Bird, S. D., Blobel, V., Bloodworth, I. J., Bobinski, M., Bock, P., Bonacorsi, D., Boutemeur, M., Braibant, S., Brigliadori, L., Brown, R. M., Burckhart, H. J., Burgard, C., Bürgin, R., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrisman, D., Clarke, P. E. L., Cohen, I., Conboy, J. E., Cooke, O. C., Couyoumtzelis, C., Coxe, R. L., Cuffiani, M., Dado, S., Dallapiccola, C., Dallavalle, G. M., Davis, R., de Jong, S., del Pozo, L. A., de Roeck, A., Desch, K., Dienes, B., Dixit, M. S., Doucet, M., Dnchovni, E., Duckeck, G., Duerdoth, I. P., Eatough, D., Estabrooks, P. G., Etzion, E., Evans, H. G., Evans, M., Fabbri, F., Fanfani, A., Fanti, M., Faust, A. A., Feld, L., Fiedler, F., Fierro, M., Fischer, H. M., Fleck, I., Folman, R., Fong, D. G., Foucher, M., Fiirtjes, A., Futyan, D. I., Gagnon, P., Gary, J. W., Gascon, J., Gascon-Shotkin, S. M., Geddes, N. I., Geich-Gimbel, C., Geralis, T., Giacomelli, G., Giacomelli, P., Giacomelli, R., Gibson, V., Gibson, W. R., Gingrich, D. M., Glenzinski, D., Goldberg, J., Goodrick, M. J., Gorn, W., Grandi, C., Gross, E., Grunhaus, J., Gruwé, M., Hajdu, C., Hanson, G. G., Hansroul, M., Hapke, M., Hargrove, C. K., Hart, P. A., Hartmann, C., Hauschild, M., Hawkes, C M., Hawkings, R., Hemingway, R. J., Hcrndon, M., Herten, G., Heuer, R. D., Hildreth, M. D., Hill, J. C., Hillier, S. J., Hobson, P. R., Hocker, A., Homer, R. J., Honma, A. K., Horvath, D., Hossain, K. R., Howard, R., Hüntemeyer, P., Hutchcroft, D. E., Igo-Kemenes, P., Imrie, D. C., Ishii, K., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Joly, A., Jones, C. R., Jones, M., Jost, U., Jovanovic, P., Junk, T. R., Kanzaki, J., Karlen, D., Kartvelishvili, V., Kawagoe, K., Kawamoto, T., Kayal, P. I., Keeler, R. K., Kellogg, R. G., Kennedy, B. W., Kirk, J., Klier, A., Kluth, S., Kobayashi, T., Kobel, M., Koetke, D. S., Kokott, T. P., Kolrep, M., Komamiya, S., Kowalewski, R. V., Kress, T., Krieger, P., von Krogh, J., Kyberd, P., Lafferty, G. D., Lahmann, R., Lai, W. P., Lanske, D., Lauber, J., Lautenschlager, S. R., Lawson, I., Layter, J. G., Lazic, D., Lee, A. M., Lefebvre, E., Lellouch, D., Letts, J., Levinson, L., List, B., Lloyd, S. L., Loebinger, F. K., Long, G. D., Losty, M. J., Ludwig, J., Lui, D., Maechiolo, A., Macpherson, A., Mannelli, M., Marcellini, S., Markopoulos, C., Markus, C., Martin, A. J., Martin, J. P., Martinez, G., Mashimo, T., Mättig, P., McDonald, W. J., McKenna, J., Mckigney, E. A., McMahon, T. J., McPherson, R. A., Meijers, F., Menke, S., Merritt, F. S., Mes, H., Meyer, J., Michelini, A., Mihara, S., Mikenberg, G., Miller, D. J., Mincer, A., Mir, R., Mohr, W., Montanari, A., Mori, T., Mihara, S., Nagai, K., Nakaumra, I., Neal, H. A., Nellen, B., Nisius, R., O’Neale, S. W., Oakham, F. G., Odorici, F., Ogren, H. O., Oh, A., Oldershaw, N. J., Oreglia, M. J., Orito, S., Pálinkás, J., Pásztor, G., Pater, J. R., Patrick, G. N., Patt, J., Perez-Ochoa, R., Petzold, S., Pfeifenschneider, P., Pilcher, J. E., Pinfold, J., Plane, D. E., Poffenberger, P., Poli, B., Posthaus, A., Rembser, C., Robertson, S., Robins, S. A., Rodning, N., Roney, J. M., Rooke, A., Rossi, A. M., Routenburg, P., Rozen, Y., Runge, K., Runolfsson, O., Ruppel, U., Rust, D. R., Sachs, K., Saeki, T., Sahr, O., M. Sang, W., Sarkisyan, E. K. G., Sbarra, C., Schalle, A. D., Schaile, O., Scharf, F., Scharff-Hansen, P., Schieck, J., Schleper, P., Schmitt, B., Schmitt, S., Schöning, A., Schröder, M., Schumacher, M., Schwick, C., Scott, W. G., Shears, T. G., Shen, B. C., Shepherd-Themistocleous, C. H., Sherwood, P., Siroli, G. P., Sittler, A., Skillman, A., Skuja, A., Smith, A. M., Snow, G. A., Sobie, R., Söldner-Rembold, S., Springer, R. W., Sproston, M., Stephens, K., Steuerer, J., Stockhausen, B., Stoll, K., Strom, D., Ströhmer, R., Szymanski, P., Tafirout, R., Talbot, S. D., Taras, P., Tarera, S., Teuscher, R., Thiergen, M., Thomson, M. A., von Törne, E., Torrence, E., Towers, S., Trigger, I., Trocsányi, Z., Tsur, E., Turcot, A. S., Turner-Watson, M. F., Ueda, I., Utzat, P., Van Koten, R., Vannerem, P., Verzocchi, M., Vikas, P., Vokurka, E. H., Voss, H., Wäckerle, F., Wagner, A., Ward, C. P., Ward, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Wells, P. S., Wermes, N., White, J. S., Wilson, G. W., Wilson, J. A., Wyatt, T. R., Yamashita, S., Yekutieli, G., Zacek, V., and Zer-Zion, D.

Published
1998
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42. Search for unstable heavy and excited leptons in e+e− collisions at ∝s = 170-172 GeV

Author

Ackerstaff, K., Alexander, G., Allison, J., Altekamp, N., Anderson, K. vJ., Anderson, S., Arcellie, S., Asai, S., Axen, D., Azuelos, G., Ball, A. H., Barberio, E., Barlow, R. J., Bartoldus, R., Batley, J. R., Baumann, S., Bechtluft, J., Beeston, C., Behnke, T., Bell, A. N., Bell, K. W., Bella, G., Bentvelsen, S., Bethke, S., Biebel, O., Biguzzi, A., Bird, S. D., Blobel, V., Bloodworth, I. J., Bloomer, J. E., Bobinski, M., Bock, P., Bonacorsi, D., Boutemeur, M., Bouwens, B. T., Braibant, S., Brigliadori, L., Brown, R. M., Burckhart, H. J., Burgard, C., Bürgin, R., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrisman, D., Clarke, P. E. L., Cohen, I., Conboy, J. E., Cooke, O. C., Cuffiani, M., Dado, S., Dallapiccola, C., Dallavalle, G. M., Davis, R., De Jong, S., del Pozo, L. A., Desch, K., Dienes, B., Dixit, M. S., do Couto e Silva, E., Doucet, M., Duchovni, E., Duckeck, G., Duerdoth, I. P., Eatough, D., Edwards, J. E. G., Estabrooks, P. G., Evans, H. G., Evans, M., Fabbri, F., Fanti, M., Faust, A. A., Fiedler, F., Fierro, M., Fischer, H. M., Fleck, I., Folman, R., Fong, D. G., Foucher, M., Fürtjes, A., Futyan, D. I., Gagnon, P., Gary, J. W., Gascon, J., Gascon-Shotkin, S. M., Geddes, N. I., Geich-Gimbe, C., Geralis, T., Giacomelli, G., Giacomelli, P., Giacomelli, R., Gibson, V., Gibson, W. R., Gingrich, D. M., Glenzinski, D., Goldberg, J., Goodrick, M. J., Gorn, W., Grandi, C., Gross, E., Grunhaus, J., Gruwé, M., Hajdu, C., Hanson, G. G., Hansroul, M., Hapke, M., Hargrove, C. K., Hart, P. A., Hartmann, C., Hauschild, M., Hawkes, C. M., Hawkings, R., Hemingway, R. J., Herndon, M., Herten, G., Heuer, R. D., Hildreth, M. D., Hill, J. C., Hillier, S. J., Hobson, P. R., Homer, R. J., Honma, A. K., Horvdth, D., Hossain, K. R., Howard, R., Hüntemeyer, P., Hutchcroft, D. E., Igo-Kemenes, P., Imrie, D. C., Ingram, M. R., Ishii, K., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Joly, A., Jones, C. R., Jones, G., Jones, M., Jost, U., Jovanovic, P., Junk, T. R., Karlen, D., Kartvelishvili, V., Kawagoe, K., Kawamoto, T., Kayal, P. I., Keeler, R. K., Kellogg, R. G., Kennedy, B. W., Kirk, J., Klier, A., Kluth, S., Kobayashi, T., Kobel, M., Koetke, D. S., Kokott, T. P., Kolrep, M., Komamiya, S., Kress, T., Krieger, P., von Krogh, J., Kyberd, P., Lafferty, G. D., Lahmann, R., Lai, W. P., Lanske, D., Lauber, J., Lautenschlager, S. R., Layter, J. G., Lazic, D., Lee, A. M., Lefebvre, E., Lellouch, D., Letts, J., Levinson, L., Lloyd, S. L., Loebinger, F. K., Loug, G. D., Losty, M. J., Ludwig, J., Macchiolo, A., Macpherson, A., Mannelli, M., Marcellini, S., Markus, C., Martin, A. J., Martin, J. P., Martinez, G., Mashimo, T., Mättig, P., McDonald, W. J., McKenna, J., Mckigney, E. A., McMahon, T. J., McPherson, R. A., Meijers, F., Menke, S., Merritt, F. S., Mes, H., Meyer, J., Michelini, A., Mikenberg, G., Miller, D. J., Mincer, A., Mir, R., Mohr, W., Montanari, A., Mori, T., Morii, M., Müller, U., Mihara, S., Nagai, K., Nakamura, I., Neal, H. A., Nellen, B., Nisius, R., O'Neale, S. W., Oakham, F. G., Odorici, F., Ogren, H. O., Oh, A., Oldershaw, N. J., Oreglia, M. J., Orito, S., Pálinkás, J., Pásztor, G., Pater, J. R., Patrick, G. N., Patt, J., Pearce, M. J., Perez-Ochoa, R., Petzold, S., Pfeifenschneider, P., Pilcher, J. E., Pinfold, J., Plane, D. E., Poffenberger, P., Poli, B., Posthaus, A., Rees, D. L., Rigby, D., Robertson, S., Robins, S. A., Rodning, N., Roney, J. M., Rooke, A., Ros, E., Rossi, A. M., Routenburg, P., Rozen, Y., Runge, K., Runolfsson, O., Ruppel, U., Rust, D. R., Rylko, R., Sachs, K., Saeki, T., Sarkisyan, E. K. G., Sbarra, C., Schaile, A. D., Schaile, O., Scharf, F., Scharf-Hansen, P., Schenk, P., Schieck, J., Schleper, P., Schmitt, B., Schmitt, S., Schöning, A., Schröder, M., Schultz-Coulon, H. C., Schumacher, M., Schwick, C., Scott, W. G., Shears, T. G., Shen, B. C., Shepherd-Themistocleous, C. H., Sherwood, P., Siroli, G. P., Sittler, A., Skillman, A., Skuja, A., Smith, A. M., Snow, G. A., Sobie, R., Söldner-Rembold, S., Springer, R. W., Sproston, M., Stephens, K., Steuerer, J., Stockhausen, B., Stoll, K., Strom, D., Szymanski, Strom, Tafirout, R., Talbot, S. D., Tanaka, S., Taras, P., Tarem, S., Teuscher, R., Thiergen, M., Thomson, M. A., von Törne, E., Towers, S., Trigger, I., Trócsányi, Z., Tsur, E., Turcot, A. S., Turner-Watson, M. F., Utzat, P., Van Kooten, R., Verzocchi, M., Vikas, P., Vokurka, E. H., Voss, H., Wäckerle, F., Wagner, A., Ward, C. P., Wards, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Wells, P. S., Wermes, N., White, J. S., Wilkens, B., Wilson, G. W., Wilson, J. A., Wolf, G., Wyatt, T. R., Yamashita, S., Yekutieli, G., Zacek, V., Zer-Zion, D., and OPAL Collaboration

Published
1998
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43. Search for a massive Di-photon resonance at ∝s = 91 – 172 GeV

Author

Ackerstaff, K., Alexander, G., Allison, J., Altekamp, N., Anderson, K. J., Anderson, S., Arcelli, S., Asai, S., Axen, D., Azuelos, G., Ball, A. H., Barberio, E., Barlow, R. J., Bartoldus, R., Batley, J. R., Baumann, S., Bechtluft, J., Beeston, C., Behnke, T., Bell, A. N., Bell, K. W., Bella, G., Bentvelsen, S., Bethke, S., Biebel, O., Biguzzi, A., Bird, S. D., Blobel, V., Bloodworth, I. J., Bloomer, J. E., Bobinski, M., Bock, P., Bonacorsi, D., Boutemeur, M., Bouwens, B. T., Braibant, S., Brigliadori, L., Brown, R. M., Burckhart, H. J., Burgard, C., Bürgin, R., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrisman, D., Clarke, P. E. L., Cohen, I., Conboy, J. E., Cooke, O. C., Cuffiani, M., Dado, S., Dallapiccola, C., Dallavalle, G. M., Davis, R., De Jong, S., del Pozo, L. A., Desch, K., Dienes, B., Dixit, M. S., do Couto e Silva, E., Doucet, M., Duchovni, E., Duckeck, G., Duerdoth, I. P., Eatough, D., Edwards, J. E. G., Estabrooks, P. G., Evans, H. G., Evans, M., Fabbri, F., Fanti, M., Faust, A. A., Fiedler, F., Fierro, M., Fischer, H. M., Fleck, I., Folman, R., Fong, D. G., Foucher, M., Fürtjes, A., Futyan, D. I., Gagnon, P., Gary, J. W., Gascon, J., Gascon-Shotkin, S. M., Geddes, N. I., Geich-Gimbel, C., Geralis, T., Giacomelli, G., Giacomelli, P., Giacomelli, R., Gibson, V., Gibson, W. R., Gingrich, D. M., Glenzinski, D., Goldberg, J., Goodrick, M. J., Gorn, W., Grandi, C., Gross, E., Grunhaus, J., Gruwé, M., Hajdu, C., Hanson, G. G., Hansroul, M., Hapke, M., Hargrove, C. K., Hart, P. A., Hartmann, C., Hauschild, M., Hawkes, C. M., Hawkings, R., Hemingway, R. J., Herndon, M., Herten, G., Heuer, R. D., Hildreth, M. D., Hill, J. C., Hillier, S. J., Hobson, P. R., Homer, R. J., Honma, A. K., Horvath, D., Hossain, K. R., Howard, R., Huntemeyer, P., Hutchcroft, D. E., Igo-Kemenes, P., Imrie, D. C., Ingram, M. R., Ishii, K., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Joly, A., Jones, C. R., Jones, G., Jones, M., Jost, U., Jovanovic, P., Junk, T. R., Karlen, D., Kartvelishvili, V., Kawagoe, K., Kawamoto, T., Kayal, P. I., Keeler, R. K., Kellogg, R. G., Kennedy, B. W., Kirk, J., Klier, A., Kluth, S., Kobayashi, T., Kobel, M., Koetke, D. S., Kokott, T. P., Kolrep, M., Komamiya, S., Kress, T., Krieger, P., von Krogh, J., Kyberd, P., Lafferty, G. D., Lahmann, R., Lai, W. P., Lanske, D., Lauber, J., Lautenschlager, S. R., Layter, J. G., Lazic, D., Lee, A. M., Lefebvre, E., Lellouch, D., Letts, J., Levinson, L., Lloyd, S. L., Loebinger, F. K., Long, G. D., Losty, M. J., Ludwig, J., Macchiolo, A., Macpherson, A., Mannelli, M., Marcellini, S., Markus, C., Martin, A. J., Martin, J. P., Martinez, G., Mashimo, T., Mattig, P., McDonald, W. J., McKenna, J., Mckigney, E. A., McMahon, T. J., McPherson, R. A., Meijers, F., Menke, S., Merritt, F. S., Mes, H., Meyer, J., Michelini, A., Mikenberg, G., Miller, D. J., Mincer, A., Mir, R., Mohr, W., Montanari, A., Mori, T., Morii, M., Müller, U., Mihara, S., Nagai, K., Nakamura, I., Neal, H. A., Nellen, B., Nisius, R., O'Neale, S. W., Oakham, F. G., Odorici, F., Ogren, H. O., Oh, A., Oldershaw, N. J., Oreglia, M. J., Orito, S., Pálinkás, J., Pasztor, G., Pater, J. R., Patriek, G. N., Patt, J., Pearce, M. J., Perez-Ochoa, R., Petzold, S., Pfeifenschneider, P., Pilcher, J. E., Pinfold, J., Plane, D. E., Poffenberger, P., Poli, B., Posthaus, A., Rees, D. L., Rigby, D., Robertson, S., Robins, S. A., Rodning, N., Roney, J. M., Rooke, A., Ros, E., Rossi, A. M., Routenburg, P., Rozen, Y., Runge, K., Runolfsson, O., Ruppel, U., Rust, D. R., Rylko, R., Sachs, K., Saeki, T., Sarkisyan, E. K. G., Sbarra, C., Schaile, A. D., Schaile, O., Scharf, F., Scharff-Hansen, P., Schenk, P., Schieck, J., Schleper, P., Schmitt, B., Schmitt, S., Schoning, A., Schröder, M., Schultz-Coulon, H. C., Schumacher, M., Schwick, C., Scott, W. G., Shears, T. G., Shen, B. C., Shepherd-Themistocleous, C. H., Sherwood, P., Siroli, G. P., Sittler, A., Skillman, A., Skuja, A., Smith, A. M., Snow, G. A., Sobie, R., Sölduer-Rembold, S., Springer, R. W., Sproston, M., Stephens, K., Steuerer, J., Stockhausen, B., Stoll, K., Strom, D., Szymanski, P., Tafirout, R., Talbot, S. D., Tanaka, S., Taras, P., Tarem, S., Teuscher, R., Thiergen, M., Thomson, M. A., von Torne, E., Towers, S., Trigger, I., Trocsanyi, Z., Tsur, E., Turcot, A. S., Turner-Watson, M. F., Utzat, P., Van Kooten, R., Verzocchi, M., Vikas, P., Vokurka, E. H., Voss, H., Wäckerle, F., Wagner, A., Wards, C. P., Wards, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Wells, P. S., Wermes, N., White, J. S., Wilkens, B., Wilson, G. W., Wilson, J. A., Wolf, G., Wyatt, T. R., Yamashita, S., Yekutieli, G., Zacek, V., Zer-Zion, D., and OPAL Collaboration

Published
1998
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44. Multi-photon final states in e+e− collisions at ∝s =130-172 GeV

Author

Ackerstaff, K., Alexander, G., Allison, J., Altekamp, N., Anderson, K. J., Anderson, S., Arcelli, S., Asai, S., Axen, D., Azuelos, G., Ball, A. H., Barberio, E., Barlow, R. J., Bartoldus, R., Batley, J. R., Baumann, S., Bechtluft, J., Beeston, C., Behnke, T., Bell, A. N., Bella, K. W., Bella, G., Bentvelsen, S., Bethke, S., Biebel, O., Biguzzi, A., Bird, S. D., Blobel, V., Bloodworth, I. J., Bloomer, J. E., Bobinskilo, M., Bock, P., Bonacorsi, D., Boutemeur, M., Bouwens, B. T., Braibant, S., Brigliadori, L., Brown, R. M., Burckhart, H. J., Burgard, C., Biirgin, R., Capiluppi, P., Carnegie, R. K., Carter, A. A., Carter, J. R., Chang, C. Y., Charlton, D. G., Chrisman, D., Clarke, P. E. L., Cohen, I., Conboy, J. E., Cooke, O. C., Cuffiani, M., Dado, S., Dallapiccola, C., Dallavalle, G. M., Davis, R., De Jong, S., del Pozo, L. A., Desch, K., Dienes, B., Dixit, M. S., do Couto e Silva, E., Doucet, M., Duchovni, E., Duckeck, G., Duerdoth, I. P., Eatough, D., Edwards, J. E. G., Estabrooks, P. G., Evans, H. G., Evans, M., Fabbri, F., Fanti, M., Faust, A. A., Fiedler, F., Fierro, M., Fischer, H. M., Fleck, I., Folman, R., Fong, D. G., Foucher, M., Fürtjes, A., Futyan, D. I., Gagnon, P., Gary, J. W., Gascon, J., Gascon-Shotkin, S. M., Geddes, N. I., Geich-Gimbel, C., Geralis, T., Giacomelli, G., Giacomelli, P., Giacomelli, R., Gibson, V., Gibson, W. R., Gingrich, D. M., Glenzinski, D., Goldberg, J., Goodrick, M. J., Gorn, W., Grandi, C., Gross, E., Grunhaus, J., Gruwé, M., Hajdu, C., Hanson, G. G., Hansroul, M., Hapke, M., Hargrove, C. K., Hart, P. A., Hartmann, C., Hauschild, M., Hawkes, C. M., Hawkings, R., Hemingway, R. J., Herndon, M., Herten, G., Heuer, R. D., Hildreth, M. D., Hill, J. C., Hillier, S. J., Hobson, P. R., Homer, R. J., Honma, A. K., Horvath, D., Hossain, K. R., Howard, R., Hüntemeyer, P., Hutchcroft, D. E., Igo-Kemenes, P., Imrie, D. C., Ingram, M. R., Ishii, K., Jawahery, A., Jeffreys, P. W., Jeremie, H., Jimack, M., Joly, A., Jones, C. R., Jones, G., Jones, M., Jost, U., Jovanovic, P., Junk, T. R., Karlen, D., Kartvelishvili, V., Kawagoe, K., Kawamoto, T., Kayal, P. I., Keeler, R. K., Kellogg, R. G., Kennedy, B. W., Kirk, J., Klier, A., Kluth, S., Kobayashi, T., Kobello, M., Koetke, D. S., Kokott, T. P., Kolrep, M., Komamiya, S., Kress, T., Krieger, P., von Krogh, J., Kyberd, P., Lafferty, G. D., Lahmann, R., Lai, W. P., Lanske, D., Lauber, J., Lautenschlager, S. R., Layter, J. G., Lazic, D., Lee, A. M., Lefebvre, E., Lellouch, D., Letts, J., Levinson, L., Lloyd, S. L., Loebinger, F. K., Long, G. D., Losty, M. J., Ludwig, J., Macchiolo, A., Macpherson, A., Mannelli, M., Marcellini, S., Markus, C., Martin, A. J., Martin, J. P., Martinez, G., Mashimo, T., Mättig, P., McDonald, W. J., McKenna, J., Mckigney, E. A., McMahon, T. J., McPherson, R. A., Meijers, F., Menke, S., Merritt, F. S., Mes, H., Meyer, J., Michelini, A., Mikenberg, G., Miller, D. J., Mincer, A., Mir, R., Mohr, W., Montanari, A., Mori, T., Morii, M., Müller, U., Mihara, S., Nagai, K., Nakamura, I., Neal, H. A., Nellen, B., Nisius, R., O'Neale, S. W., Oakham, F. G., Odorici, F., Ogren, H. O., Oh, A., Oldershaw, N. J., Oreglia, M. J., Orito, S., Palinkas, J., Pasztor, G., Pater, J. R., Patriek, G. N., Patt, J., Pearce, M. J., Perez-Ochoa, R., Petzold, S., Pfeifenschneider, P., Pilcher, J. E., Pinfold, J., Plane, D. E., Poffenberger, P., Poli, B., Posthaus, A., Rees, D. L., Rigby, D., Robertson, S., Robins, S. A., Rodning, N., Roney, J. M., Rooke, A., Ros, E., Rossi, A. M., Routenburg, P., Rozen, Y., Runge, K., Runolfsson, O., Ruppel, U., Rust, D. R., Rylko, R., Sachs, K., Saeki, T., Sarkisyan, E. K. G., Sbarra, C., Schaile, A. D., Schaile, O., Scharf, F., Scharff-Hansen, P., Schenk, P., Schieck, J., Schleper, P., Schmitt, B., Schmitt, S., Schöning, A., Schröder, M., Schultz-Coulon, H. C., Schumacher, M., Schwick, C., Scott, W. G., Shears, T. G., Shen, B. C., Shepherd-Themistocleous, C. H., Sherwood, P., Siroli, G. P., Sittler, A., Skillman, A., Skuja, A., Smith, A. M., Snow, G. A., Sobie, R., Söldner-Rembold, S., Springer, R. W., Sproston, M., Stephens, K., Steuerer, J., Stockhausen, B., Stoll, K., Strom, D., Szymanski, P., Tafirout, R., Talbot, S. D., Tanaka, S., Taras, P., Tarem, S., Teuscher, R., Thiergen, M., Thomson, M. A., von Törne, E., Towers, S., Trigger, I., Trócsányi, Z., Tsur, E., Turcot, A. S., Turner-Watson, M. F., Utzat, P., Van Kooten, R., Verzocchi, M., Vikas, P., Vokurka, E. H., Voss, H., Wackerle, F., Wagner, A., Wards, C. P., Wards, D. R., Watkins, P. M., Watson, A. T., Watson, N. K., Wells, P. S., Wermes, N., White, J. S., Wilkens, B., Wilson, G. W., Wilson, J. A., Wolf, G., Wyatt, T. R., Yamashita, S., Yekutieli, G., Zacek, V., Zer-Zion, D., and The OPAL Collaboration

Published
1998
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45. Search for single production of a heavy vector-like T quark decaying to a Higgs boson and a top quark with a lepton and jets in the final state

Author

Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Asilar, E., Bergauer, T., Brandstetter, J., Brondolin, E., Dragicevic, M., Eroe, J., Flechl, M., Friedl, M., Fruehwirth, R., Ghete, V. M., Hartl, C., Hormann, N., Hrubec, J., Jeitler, M., Koenig, A., Kraetschmer, I., Liko, D., Matsushita, T., Mikulec, I., Rabady, D., Rad, N., Rahbaran, B., Rohringer, H., Schieck, J., Strauss, J., Waltenberger, W., Wulz, C. -. E., Dvornikov, O., Makarenko, V., Zykunov, V., Mossolov, V., Shumeiko, N., Gonzalez, J. Suarez, Alderweireldt, S., De Wolf, E. A., Janssen, X., Lauwers, J., Van de Klundert, M., Van Haevermaet, H., Van Mechelen, R., Van Remortel, N., Van Spilbeeck, A., Abu Zeid, S., Blekman, F., D'Hondt, J., Daci, N., De Bruyn, I., Deroover, K., Lowette, S., Moortgat, S., Moreels, L., Olbrechts, A., Python, Q., Tavernier, S., Van Doninck, W., Van Mulders, R., Van Parijs, I., Brun, H., Clerbaux, B., De Lentdecker, G., Delannoy, H., Fasanella, G., Favart, L., Goldouzian, R., Grebenyuk, A., Karapostoli, G., Lenzi, T., Leonard, A., Luetic, J., Maerschalk, T., Marinov, A., Randle-Conde, A., Seva, T., Velde, C. Vander, Vanlaer, R., Vannerom, D., Yonamine, R., Zenoni, F., Zhang, F., Cimmino, A., Cornelis, T., Dobur, D., Fagot, A., Garcia, G., Gul, M., Khvastunov, I., Poyraz, D., Salva, S., Schofbeck, R., Sharma, A., Tytgat, M., Van Driessche, W., Yazgan, E., Zaganidis, N., Bakhshiansohi, H., Beluffi, C., Bondu, O., Brochet, S., Bruno, G., Caudron, A., De Visscher, S., Delaere, C., Delcourt, M., Francois, B., Giammanco, A., Jafari, A., Jez, P., Komm, M., Krintiras, G., Lemaitre, V., Magitteri, A., Mertens, A., Musich, M., Nuttens, C., Piotrzkowski, K., Quertenmont, L., Selvaggi, M., Marono, M. Vidal, Wertz, S., Beliy, N., Alda Junior, W. L., Alves, F. L., Alves, G. A., Brito, L., Hensel, C., Moraes, A., Pol, M. E., Rebello Teles, R., Belchior Batista Das Chagas, E., Carvalho, W., Chinellato, J., Custodio, A., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., De Oliveira Martins, C., Fonseca De Souza, S., Huertas Guativa, L. M., Malbouisson, H., Matos Figueiredo, D., Herrera, C. Mora, Mundim, L., Nogima, H., Prado Da Silva, W. L., Santoro, A., Sznajder, A., Tonelli Manganote, E. J., Vilela Pereira, A., Ahuja, S., Bernardes, C. A., Dogra, S., Fernandez Perez Tomei, T. R., Gregores, E. M., Mercadante, P. G., Moon, C. S., Novaes, S. F., Padula, S., Romero Abad, D., Ruiz Vargas, J. C., Aleksandrov, A., Hadjiiska, R., Iaydjiev, R., Rodozov, M., Stoykova, S., Sultanov, G., Vutova, M., Dimitrov, A., Glushkov, I., Litov, L., Pavlov, B., Petkov, P., Fang, W., Ahmad, M., Bian, J. G., Chen, G. M., Chen, H. S., Chen, M., Chen, Y., Cheng, T., Jiang, C. H., Leggat, D., Liu, Z., Romeo, F., Shaheen, S. M., Spiezia, A., Tao, J., Wang, C., Wang, Z., Zhang, H., Zhao, J., Ban, Y., Chen, G., Li, Q., Liu, S., Mao, Y., Qian, S. J., Wang, D., Xu, Z., Avila, C., Cabrera, A., Chaparro Sierra, L. F., Florez, C., Gomez, J. P., Gonzalez Hernandez, C. F., Ruiz Alvarez, J. D., Sanabria, J. C., Godinovic, N., Lelas, D., Puljak, I., Ribeiro Cipriano, P. M., Sculac, T., Antunovic, Z., Kovac, M., Brigljevic, V., Ferencek, D., Kadija, K., Micanovic, S., Sudic, L., Susa, T., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Tsiakkouri, D., Fingers, M., Finger, M., J. r., Carrera Jarrin, E., Assran, Y., Elkafrawy, T., Mahrous, A., Calpas, B., Kadastik, M., Murumaa, M., Perrini, L., Raidal, M., Tiko, A., Veelken, C., Eerola, P., Pekkanen, J., Voutilainen, M., Harkonen, J., Jarvinen, T., Karimaki, V., Kinnunen, R., Lampen, T., Lassila-Perini, K., Lehti, S., Linden, T., Luukka, P., Tuominiemi, J., Tuovinen, E., Wendland, L., Talvitie, J., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Fabbro, B., Faure, J. L., Favaro, C., Ferri, F., Ganjour, S., Ghosh, S., Givernaud, A., Gras, R., de Monchenault, G. 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I., Henderson, C., Rumerio, R., West, C., Arcaro, D., Avetisyan, A., Bose, T., Gastler, D., Rankin, D., Richardson, C., Rohlf, J., Sulak, L., Zou, D., Benelli, G., Berry, E., Cutts, D., Garabedian, A., Hakala, J., Heintz, U., Hogan, J. M., Jesus, O., Kwok, K. H. M., Laird, E., Landsberg, G., Mao, Z., Narain, M., Piperov, S., Sagir, S., Spencer, E., Syarif, R., Breedon, R., Breto, G., Sanchez, M. Calderon De La Barca, Chertok, M., Conway, J., Conway, R., Cox, P. T., Erbacher, R., Flores, C., Funk, G., Gardner, M., Ko, W., Lander, R., Mclean, C., Mulhearn, M., Pellett, D., Pilot, J., Shalhout, S., Smith, J., Squires, M., Stolp, D., Tripathi, M., Wilbur, S., Yohay, R., Bravo, C., Cousins, R., Dasgupta, A., Everaerts, R., Florent, A., Hauser, J., Ignatenko, M., Mccoll, N., Saltzberg, D., Schnaible, C., Takasugi, E., Valuev, V., Burt, K., Clare, R., Ellison, J., Gary, J. W., Shirazi, S. M. A. Ghiasi, Hanson, G., Heilman, J., Jandir, R., Kennedy, E., Lacroix, F., Long, O. R., Negrete, M. 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M., Maruyama, S., Mason, D., Mcbride, R., Merkel, R., Mrenna, S., Nahn, S., Newman-Holmes, C., O'Dell, V., Pedro, K., Prokofyev, O., Rakness, G., Ristori, L., Sexton-Kennedy, E., Soha, A., Spalding, W. J., Spiegel, L., Stoynev, S., Strait, J., Strobbe, N., Taylor, L., Tkaczyk, S., Tran, N. V., Uplegger, L., Vaandering, E. W., Vernieri, C., Verzocchi, M., Vidal, R., Wang, M., Weber, H. A., Whitbeck, A., Wu, Y., Acosta, D., Avery, R., Bortignon, R., Bourilkov, D., Brinkerhoff, A., Carnes, A., Carver, M., Curry, D., Das, S., Field, R. D., Furic, I. K., Konigsberg, J., Korytov, A., Low, J. F., Ma, R., Matchev, K., Mei, H., Mitselmakher, G., Rank, D., Shchutska, L., Sperka, D., Thomas, L., Wang, J., Wang, S., Yelton, J., Linn, S., Markowitz, R., Martinez, G., Rodriguez, J. L., Ackert, A., Adams, J. R., Adams, T., Askew, A., Bein, S., Diamond, B., Hagopian, S., Hagopian, V., Johnson, K. F., Khatiwada, A., Prosper, H., Santra, A., Baarmand, M. M., Bhopatkar, V., Colafranceschi, S., Hohlmann, M., Noonan, D., Roy, T., Yumiceva, F., Adams, M. R., Apanasevich, L., Berry, D., Betts, R. R., Bucinskaite, I., Cavanaugh, R., Evdokimov, O., Gauthier, L., Gerber, C. E., Hofman, D. J., Jung, K., Kurt, R., O'Brien, C., Gonzalez, I. D. Sandoval, Turner, R., Varelas, N., Wang, H., Wu, Z., Zakaria, M., Zhang, J., Bilki, B., Clarida, W., Dilsiz, K., Durgut, S., Gandrajula, R. P., Haytmyradov, M., Khristenko, V., Merlo, J. -R, Mermerkaya, H., Mestvirishvili, A., Moeller, A., Nachtman, J., Ogul, H., Onel, Y., Ozok, F., Penzo, A., Snyder, C., Tiras, E., Wetzel, J., Yi, K., Anderson, I., Blumenfeld, B., Cocoros, A., Eminizer, N., Fehling, D., Feng, L., Gritsan, A. V., Maksimovic, R., Martin, C., Osherson, M., Roskes, J., Sarica, U., Swartz, M., Xiao, M., Xin, Y., You, C., Al-Bataineh, A., Baringer, P., Bean, A., Boren, S., Bowen, J., Bruner, C., Castle, J., Forthomme, L., Kenny, R. P., Iii, Khalil, S., Kropivnitskaya, A., Majumder, D., Mcbrayer, W., Murray, M., Sanders, S., Stringer, R., Takaki, J. D. Tapia, Wang, Q., Ivanov, A., Kaadze, K., Maravin, Y., Mohammadi, A., Saini, L. K., Skhirtladze, N., Toda, S., Rebassoo, F., Wright, D., Anelli, C., Baden, A., Baron, O., Belloni, A., Calvert, B., Eno, S. C., Ferraioli, C., Gomez, J. A., Hadley, N. J., Jabeen, S., Kellogg, R. G., Kolberg, T., Kunkle, J., Lu, Y., Mignerey, A. C., Ricci-Tam, F., Shin, Y. H., Skuja, A., Tonjes, M. B., Tonwar, S. C., Abercrombie, D., Allen, B., Apyan, A., Barbieri, R., Baty, A., Bi, R., Bierwagen, K., Brandt, S., Busza, W., Cali, I. A., Demiragli, Z., Di Matteo, L., Ceballos, G. Gomez, Goncharov, M., Hsu, D., Iiyama, Y., Innocenti, G. M., Klute, M., Kovalskyi, D., Krajczar, K., Lai, Y. S., Lee, Y. -. J., Levin, A., Luckey, P. D., Maier, B., Marini, A. C., Mcginn, C., Mironov, C., Narayanan, S., Niu, X., Paus, C., Roland, C., Roland, G., Salfeld-Nebgen, J., Stephans, G. S. F., Sumorok, K., Tatar, K., Varma, M., Velicanu, D., Veverka, J., Wang, T. W., Wyslouch, B., Yang, M., Zhukova, V., Benvenuti, A. C., Chatterjee, R. M., Evans, A., Finkel, A., Gude, A., Hansen, P., Kalafut, S., Kao, S. C., Kubota, Y., Lesko, Z., Mans, J., Nourbakhsh, S., Ruckstuhl, N., Rusack, R., Tambe, N., Turkewitz, J., Acosta, J. G., Oliveros, S., Avdeeva, E., Bartek, R., Bloom, K., Claes, D. R., Dominguez, A., Fangmeier, C., Suarez, R. Gonzalez, Kamalieddin, R., Kravchenko, I., Rodrigues, A. Malta, Meier, F., Monroy, J., Siado, J. E., Snow, G. R., Stieger, B., Alyari, M., Dolen, J., George, J., Godshalk, A., Harrington, C., Iashvili, I., Kaisen, J., Kharchilava, A., Kumar, A., Parker, A., Rappoccio, S., Roozbahani, B., Alverson, G., Barberis, E., Hortiangtham, A., Massironi, A., Morse, D. M., Nash, D., Orimoto, T., De Lima, R. Teixeira, Trocino, D., Wang, R. -. J., Wood, D., Hahn, K. A., Kubik, A., Mucia, N., Odell, N., Pollack, B., Schmitt, M. H., Sung, K., Trovato, M., Velasco, M., Dev, N., Hildreth, M., Anampa, K. Hurtado, Jessop, C., Karmgard, D. J., Kellams, N., Lannon, K., Marinelli, N., Meng, F., Mueller, C., Musienko, Y., Planer, M., Reinsvold, A., Ruchti, R., Smith, G., Taroni, S., Wayne, M., Wolf, M., Woodard, A., Alimena, J., Antonelli, L., Brinson, J., Bylsma, B., Durkin, L. S., Flowers, S., Francis, B., Hart, A., Hill, C., Hughes, R., Ji, W., Liu, B., Luo, W., Puigh, D., Winer, B. L., Wulsin, H. W., Cooperstein, S., Driga, O., Elmer, P., Hardenbrook, J., Hebda, P., Lange, D., Luo, J., Marlow, D., Mc Donald, J., Medvedeva, T., Mei, K., Mooney, M., Olsen, J., Palmer, C., Piroue, P., Stickland, D., Svyatkovskiy, A., Tully, C., Zuranski, A., Barker, A., Barnes, V. E., Folgueras, S., Gutay, L., Jha, M. K., Jones, M., Jung, A. W., Miller, D. H., Neumeister, N., Schulte, J. F., Shi, X., Sun, J., Wang, F., Xie, W., Xu, L., Parashar, N., Stupak, J., Adair, A., Akgun, B., Chen, Z., Ecklund, K. M., Geurts, F. J. M., Guilbaud, M., Li, W., Michlin, B., Northup, M., Padley, B. P., Redjimi, R., Roberts, J., Rorie, J., Tu, Z., Zabel, J., Betchart, B., Bodek, A., de Barbaro, P., Demina, R., Duh, Y. t., Ferbel, T., Galanti, M., Garcia-Bellido, A., Han, J., Hindrichs, O., Khukhunaishvili, A., K. H., Lo, Tan, P., Verzetti, M., Agapitos, A., Chou, J. P., Contreras-Campana, E., Gershtein, Y., Espinosa, T. A. Gomez, Halkiadakis, E., Heindl, M., Hidas, D., Hughes, E., Kaplan, S., Elayavalli, R. Kunnawalkam, Kyriacou, S., Lath, A., Nash, K., Saka, H., Salur, S., Schnetzer, S., Sheffield, D., Somalwar, S., Stone, R., Thomas, S., Thomassen, P., Walker, M., Delannoy, A. G., Foerster, M., Heideman, J., Riley, G., Rose, K., Spanier, S., Thapa, K., Bouhali, O., Celik, A., Dalchenko, M., De Mattia, M., Delgado, A., Dildick, S., Eusebi, R., Gilmore, J., Huang, T., Juska, E., Kamon, T., Mueller, R., Pakhotin, Y., Patel, R., Perloff, A., Pernie, L., Rathjens, D., Safonov, A., Tatarinov, A., Ulmer, K. A., Akchurin, N., Cowden, C., Damgov, J., De Guio, F., Dragoiu, C., Dudero, P. R., Faulkner, J., Gurpinar, E., Kunori, S., Lamichhane, K., Libeiro, T., Peltola, T., Undleeb, S., Volobouev, I., Greene, S., Gurrola, A., Janjam, R., Johns, W., Maguire, C., Melo, A., Ni, H., Sheldon, P., Tuo, S., Velkovska, J., Xu, Q., Arenton, M. W., Barria, P., Cox, B., Goodell, J., Hirosky, R., Ledovskoy, A., Li, H., Neu, C., Sinthuprasith, T., Sun, X., Wang, Y., Wolfe, E., Xia, F., Clarke, C., Harr, R., Karchin, P. E., Sturdy, J., Belknap, D. A., Caillol, C., Dasu, S., Dodd, L., Duric, S., Gomber, B., Grothe, M., Herndon, M., Herve, A., Klabbers, P., Lanaro, A., Levine, A., Long, K., Loveless, R., Ojalvo, I., Perry, T., Pierro, G. A., Polese, G., Ruggles, T., Savin, A., Smith, N., Smith, W. H., Taylor, D., Woods, N., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CMS, Khachatryan, V, Sirunyan, A, Tumasyan, A, Adam, W, Asilar, E, Bergauer, T, Brandstetter, J, Brondolin, E, Dragicevic, M, Erö, J, Flechl, M, Friedl, M, Frühwirth, R, Ghete, V, Hartl, C, Hörmann, N, Hrubec, J, Jeitler, M, König, A, Krätschmer, I, Liko, D, Matsushita, T, Mikulec, I, Rabady, D, Rad, N, Rahbaran, B, Rohringer, H, Schieck, J, Strauss, J, Waltenberger, W, Wulz, C, Dvornikov, O, Makarenko, V, Zykunov, V, Mossolov, V, Shumeiko, N, Suarez Gonzalez, J, Alderweireldt, S, De Wolf, E, Janssen, X, Lauwers, J, Van De Klundert, M, Van Haevermaet, H, Van Mechelen, P, Van Remortel, N, Van Spilbeeck, A, Abu Zeid, S, Blekman, F, D'Hondt, J, Daci, N, De Bruyn, I, Deroover, K, Lowette, S, Moortgat, S, Moreels, L, Olbrechts, A, Python, Q, Tavernier, S, Van Doninck, W, Van Mulders, P, Van Parijs, I, Brun, H, Clerbaux, B, De Lentdecker, G, Delannoy, H, Fasanella, G, Favart, L, Goldouzian, R, Grebenyuk, A, Karapostoli, G, Lenzi, T, Léonard, A, Luetic, J, Maerschalk, T, Marinov, A, Randle-conde, A, Seva, T, Vander Velde, C, Vanlaer, P, Vannerom, D, Yonamine, R, Zenoni, F, Zhang, F, Cimmino, A, Cornelis, T, Dobur, D, Fagot, A, Garcia, G, Gul, M, Khvastunov, I, Poyraz, D, Salva, S, Schöfbeck, R, Sharma, A, Tytgat, M, Van Driessche, W, Yazgan, E, Zaganidis, N, Bakhshiansohi, H, Beluffi, C, Bondu, O, Brochet, S, Bruno, G, Caudron, A, De Visscher, S, Delaere, C, Delcourt, M, Francois, B, Giammanco, A, Jafari, A, Jez, P, Komm, M, Krintiras, G, Lemaitre, V, Magitteri, A, Mertens, A, Musich, M, Nuttens, C, Piotrzkowski, K, Quertenmont, L, Selvaggi, M, Vidal Marono, M, Wertz, S, Beliy, N, Aldá Júnior, W, Alves, F, Alves, G, Brito, L, Hensel, C, Moraes, A, Pol, M, Rebello Teles, P, Belchior Batista Das Chagas, E, Carvalho, W, Chinellato, J, Custódio, A, Da Costa, E, Da Silveira, G, De Jesus Damiao, D, De Oliveira Martins, C, Fonseca De Souza, S, Huertas Guativa, L, Malbouisson, H, Matos Figueiredo, D, Mora Herrera, C, Mundim, L, Nogima, H, Prado Da Silva, W, Santoro, A, Sznajder, A, Tonelli Manganote, E, Vilela Pereira, A, Ahuja, S, Bernardes, C, Dogra, S, Fernandez Perez Tomei, T, Gregores, E, Mercadante, P, Moon, C, Novaes, S, Padula, S, Romero Abad, D, Ruiz Vargas, J, Aleksandrov, A, Hadjiiska, R, Iaydjiev, P, Rodozov, M, Stoykova, S, Sultanov, G, Vutova, M, Dimitrov, A, Glushkov, I, Litov, L, Pavlov, B, Petkov, P, Fang, W, Ahmad, M, Bian, J, Chen, G, Chen, H, Chen, M, Chen, Y, Cheng, T, Jiang, C, Leggat, D, Liu, Z, Romeo, F, Shaheen, S, Spiezia, A, Tao, J, Wang, C, Wang, Z, Zhang, H, Zhao, J, Ban, Y, 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Subjects
electron, decay [top], lepton, 13000 GeV-cms, High Energy Physics::Lattice, B2G, B2G, CMS, Higgs tagging, Physics, Tprime, VLQ, Nuclear and High Energy Physics, quark: vector particle, Physics, Particles & Fields, top: decay, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], CMS, Higgs tagging, Physics, Tprime, VLQ, Physic, vector particle [quark], branching ratio: upper limit [cross section], left-handed [coupling], Settore FIS/01 - Fisica Sperimentale, decay [Higgs particle], Nuclear & Particles Physics, mass dependence, lcsh:QC1-999, pair production [bottom], Physics, Nuclear, CERN LHC Coll, Physical Sciences, right-handed [coupling], branching ratio, colliding beams [p p], ELECTROWEAK SYMMETRY-BREAKING, Particle Physics - Experiment, p p: scattering, Nuclear and High Energy Physics, MODEL, CERN Lab, quark: single production, FOS: Physical sciences, bottom: pair production, Astronomy & Astrophysics, 0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics, muon, mass [quark], single production [quark], ddc:530, Science & Technology, coupling: left-handed, background, High Energy Physics::Phenomenology, cross section: branching ratio: upper limit, single production, quark: mass, Physics and Astronomy, hadronic decay [Higgs particle], Higgs particle: hadronic decay, coupling: right-handed, High Energy Physics::Experiment, p p: colliding beams, lcsh:Physics, experimental results
Abstract

A search for single production of vector-like top quark partners (T) decaying into a Higgs boson and a top quark is performed using data from pp collisions at a centre-of-mass energy of 13 TeV collected by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of 2.3 inverse femtobarns. The top quark decay includes an electron or a muon while the Higgs boson decays into a pair of b quarks. No significant excess over standard model backgrounds is observed. Exclusion limits on the product of the production cross section and the branching fraction are derived in the T quark mass range 700 to 1800 GeV. For a mass of 1000 GeV, values of the product of the production cross section and the branching fraction greater than 0.8 and 0.7 pb are excluded at 95% confidence level, assuming left- and right-handed coupling of the T quark to standard model particles, respectively. This is the first analysis setting exclusion limits on the cross section of singly produced vector-like T quarks at a centre-of-mass energy of 13 TeV., Replaced with the published version. Added the journal reference. All the figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-15-008/index.html

Published
2017
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50. Validation of thymic stromal lymphopoietin as a biomarker of primary Sjögren's syndrome and related lymphoproliferation: results in independent cohorts

Author

Saviana Gandolfo, Fabro, C., Kapsogeorgou, E., Colafrancesco, S., Ferro, F., Bartoloni, E., Quartuccio, L., Goules, A., Priori, R., Alunno, A., Conti, F., Valesini, G., Giacomelli, R., Baldini, C., Gerli, R., Tzioufas, A. G., and Vita, S.

Subjects
Biomarkers, Cytokines, Greece, Humans, Italy, Sjogren's Syndrome, Thymic Stromal Lymphopoietin, sjogren's syndrome, thymic stromal lymphopoietin, biomarkers, lymphoma, mucosa-associated lymphoid tissue
Abstract

Thymic stromal lymphopoietin (TSLP) has been implicated in primary Sjögren's syndrome (pSS) and related B-cell lymphoproliferation and lymphoma (NHL) by studies on salivary pathologic tissues and serum. The purpose of this work was to validate serum TSLP as biomarker of pSS and related lymphoproliferation by the study of two additional independent cohorts.Serum TSLP was measured by ELISA in the original published Cohort-1 from Udine, Italy, including 91 patients. Two additional cohorts were then studied for validation: Cohort-2, including 4 sub-cohorts comprising 125 patients from the Universities of Roma, L'Aquila, Pisa and Perugia, belonging to the Italian SS Study Group (GRISS), and Cohort-3, including 59 patients from the University of Athens, Greece. Overall, 159 control subjects were enrolled. Active pSS-NHL, as well as pre-lymphomatous conditions, i.e. persistent salivary gland swelling and mixed cryoglobulinaemia, were investigated in detail. In addition, serum samples from pSS-NHL in complete remission were analysed (n=27).TSLP serum levels were confirmed to be significantly higher in pSS compared to controls in both Cohort-2 and Cohort-3, in particular in patients with lymphoproliferation. Serum TSLP was much higher in pSS pre-lymphomatous conditions. Finally, active NHL showed the highest TSLP serum levels, while in NHL in remission TSLP resulted undetectable or significantly lower than in benign pSS.By the study of independent cohorts, it was again demonstrated that serum TSLP levels are increased in pSS, above all in more advanced B-cell lymphoproliferation and NHL. Serum TSLP can therefore represent a novel biomarker for pSS-related lymphoproliferation.

Published
2020

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