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2. Comorbidities and treatment patterns in adult patients with atopic dermatitis: results from a nationwide multicenter study

Author

Campanati, A., Bianchelli, T., Gesuita, R., Foti, C., Malara, G., Micali, G., Amerio, P., Rongioletti, F., Corazza, M., Patrizi, A., Peris, K., Pimpinelli, N., Parodi, A., Fargnoli, M. C., Cannavo, S. P., Pigatto, P., Pellacani, G., Ferrucci, S. M., Argenziano, G., Cusano, F., Fabbrocini, G., Stingeni, L., Potenza, M. C., Romanelli, M., Bianchi, L., and Offidani, A.

Published
2022
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4. Correction to: Comorbidities and treatment patterns in adult patients with atopic dermatitis: results from a nationwide multicenter study

Author

Campanati, A., Bianchelli, T., Gesuita, R., Foti, C., Malara, G., Micali, G., Amerio, P., Rongioletti, F., Corazza, M., Patrizi, A., Peris, K., Pimpinelli, N., Parodi, A., Fargnoli, M. C., Cannavo, S. P., Pigatto, P., Pellacani, G., Ferrucci, S. M., Argenziano, G., Cusano, F., Fabbrocini, G., Stingeni, L., Potenza, M. C., Romanelli, M., Bianchi, L., and Offidani, A.

Published
2022
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5. Gender differences in adult atopic dermatitis and clinical implication: Results from a nationwide multicentre study.

Author

Marani, A., Bianchelli, T., Gesuita, R., Faragalli, A., Foti, C., Malara, G., Micali, G., Amerio, P., Rongioletti, F., Corazza, M., Patrizi, A., Peris, K., Pimpinelli, N., Parodi, A., Fargnoli, M. C., Cannavo, S. P., Pigatto, P., Pellacani, G., Ferrucci, S. M., and Argenziano, G.

Subjects
ATOPIC dermatitis, ITCHING, AGE differences, WAIST-hip ratio, DISEASE duration, ADULTS
Abstract

Background: Atopic dermatitis (AD) is a common inflammatory skin disease that affects both children and adults. However, limited research has been conducted on gender differences in AD. Objectives: This study aimed to assess gender differences in adult AD patients, focusing on demographic and clinical features, comorbidities and treatment approaches. Methods: In this multicentre, observational, cross‐sectional study, we enrolled 686 adult patients with AD (357 males and 329 females). For each patient, we collected demographic data (age and sex), anthropometric measurements (weight, height, hip circumference, waist circumference and waist‐to‐hip ratio), clinical information (onset age, disease duration, severity, itching intensity, impact on quality of life) and noted comorbidities (metabolic, atopic and other). We recorded past and current topical and systemic treatments. We analysed all collected data using statistical techniques appropriate for both quantitative and qualitative variables. Multiple correspondence analysis (MCA) was employed to evaluate the relationships among all clinical characteristics of the patients. Results: We found no differences in age at onset, disease duration, severity and quality of life impact between males and females. Males exhibited higher rates of hypertriglyceridaemia and hypertension. No significant gender differences were observed in atopic or other comorbidities. Treatment approaches were overlapping, except for greater methotrexate use in males. MCA revealed distinct patterns based on gender, disease severity, age of onset, treatment and quality of life. Adult males with AD had severe disease, extensive treatments and poorer quality of life, while adult females had milder disease, fewer treatments and moderate quality of life impact. Conclusions: Our study reveals that gender differences in adult AD patients are largely due to inherent population variations rather than disease‐related disparities. However, it highlights potential undertreatment of females with moderate AD and quality of life impact, emphasizing the need for equitable AD treatment. JAK inhibitors may offer a solution for gender‐based therapeutic parity. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Corrigendum: The silent epidemic of diabetic ketoacidosis at diagnosis of type 1 diabetes in children and adolescents in italy during the covid-19 pandemic in 2020(Front. Endocrinol., (2022), 13, (878634), 10.3389/fendo.2022.878634)

Author

Cherubini, V., Marino, M., Scaramuzza, A. E., Tiberi, V., Bobbio, A., Delvecchio, M., Piccinno, E., Ortolani, F., Innaurato, S., Felappi, B., Gallo, F., Ripoli, C., Ricciardi, M. R., Pascarella, F., Stamati, F. A., Citriniti, F., Arnaldi, C., Monti, S., Graziani, V., De Berardinis, F., Giannini, C., Chiarelli, F., Zampolli, M., De Marco, R., Bracciolini, G. P., Grosso, C., De Donno, V., Piccini, B., Toni, S., Coccioli, S., Cardinale, G., Bassi, M., Minuto, N., D?annunzio, G., Maffeis, C., Marigliano, M., Zanfardino, A., Iafusco, D., Rollato, A. S., Piscopo, A., Curto, S., Lombardo, F., Bombaci, B., Sordelli, S., Mameli, C., Macedoni, M., Rigamonti, A., Bonfanti, R., Frontino, G., Predieri, B., Bruzzi, P., Mozzillo, E., Rosanio, F., Franzese, A., Piredda, G., Cardella, F., Iovane, B., Calcaterra, V., Berioli, M. G., Lasagni, A., Pampanini, V., Patera, P. I., Schiaffini, R., Rutigliano, I., Meloni, G., De Sanctis, L., Tinti, D., Trada, M., Guerraggio, L. P., Franceschi, R., Cauvin, V., Tornese, G., Franco, F., Musolino, G., Maltoni, G., Talarico, V., Iannilli, A., Lenzi, L., Matteoli, M. C., Pozzi, E., Moretti, C., Zucchini, S., Rabbone, I., Gesuita, R., Cherubini, V., Marino, M., Scaramuzza, A. E., Tiberi, V., Bobbio, A., Delvecchio, M., Piccinno, E., Ortolani, F., Innaurato, S., Felappi, B., Gallo, F., Ripoli, C., Ricciardi, M. R., Pascarella, F., Stamati, F. A., Citriniti, F., Arnaldi, C., Monti, S., Graziani, V., De Berardinis, F., Giannini, C., Chiarelli, F., Zampolli, M., De Marco, R., Bracciolini, G. P., Grosso, C., De Donno, V., Piccini, B., Toni, S., Coccioli, S., Cardinale, G., Bassi, M., Minuto, N., D'Annunzio, G., Maffeis, C., Marigliano, M., Zanfardino, A., Iafusco, D., Rollato, A. S., Piscopo, A., Curto, S., Lombardo, F., Bombaci, B., Sordelli, S., Mameli, C., Macedoni, M., Rigamonti, A., Bonfanti, R., Frontino, G., Predieri, B., Bruzzi, P., Mozzillo, E., Rosanio, F., Franzese, A., Piredda, G., Cardella, F., Iovane, B., Calcaterra, V., Berioli, M. G., Lasagni, A., Pampanini, V., Patera, P. I., Schiaffini, R., Rutigliano, I., Meloni, G., De Sanctis, L., Tinti, D., Trada, M., Guerraggio, L. P., Franceschi, R., Cauvin, V., Tornese, G., Franco, F., Musolino, G., Maltoni, G., Talarico, V., Iannilli, A., Lenzi, L., Matteoli, M. C., Pozzi, E., Moretti, C., Zucchini, S., Rabbone, I., and Gesuita, R.

Subjects
socioeconomic status, COVID - 19, type 1 diabetes, DKA, socioeconomic statu, diabetes onset
Abstract

In the published article, there was an error in affiliation(s) 29. Instead of “Departement of Pediatrics, Diabetes Research Institute, IRCCS San Raffaele, Milano, Italy”, it should be “Diabetes Research Institute, IRCCS San Raffaele Hospital, Milan, Italy”. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Published
2022

11. Glycaemic control of Type 1 diabetes in clinical practice early in the 21st century: an international comparison

Author

McKnight, J. A., Wild, S. H., Lamb, M. J. E., Cooper, M. N., Jones, T. W., Davis, E. A., Hofer, S., Fritsch, M., Schober, E., Svensson, J., Almdal, T., Young, R., Warner, J. T., Delemer, B., Souchon, P. F., Holl, R. W., Karges, W., Kieninger, D. M., Tigas, S., Bargiota, A., Sampanis, C., Cherubini, V., Gesuita, R., Strele, I., Pildava, S., Coppell, K. J., Magee, G., Cooper, J. G., Dinneen, S. F., Eeg-Olofsson, K., Svensson, A.-M., Gudbjornsdottir, S., Veeze, H., Aanstoot, H.-J., Khalangot, M., Tamborlane, W. V., and Miller, K. M.

Published
2015
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29. User-only design to assess drug effectiveness in clinical practice: application to bisphosphonates and secondary prevention of fractures

Author

Corrao G, Ghirardi A, Segafredo G, Zambon A, Della Vedova G, Lapi F, Cipriani F, Caputi A, Gregori D, Gesuita R, Vestri A, Staniscia T, Mazzaglia G, Di Bari M, on behalf of the BEST investigators, VACCHERI, ALBERTO, Corrao, G, Ghirardi, A, Segafredo, G, Zambon, A, DELLA VEDOVA, G, Lapi, F, Cipriani, F, Caputi, A, Vaccheri, A, Gregori, D, Gesuita, R, Vestri, A, Staniscia, T, Mazzaglia, G, Di Bari, M, Best, I, Corrao G, Ghirardi A, Segafredo G, Zambon A, Della Vedova G, Lapi F, Cipriani F, Caputi A, Vaccheri A, Gregori D, Gesuita R, Vestri A, Staniscia T, Mazzaglia G, Di Bari M, and on behalf of the BEST investigators

Subjects
Male, Time Factors, pharmacoepidemiology, Databases, Factual, Fractures, Bone, Secondary Prevention, Humans, Bisphosphonate, propensity score, MED/01 - STATISTICA MEDICA, Aged, Retrospective Studies, Aged, 80 and over, user-only design, Bone Density Conservation Agents, Diphosphonates, Confounding Factors, Epidemiologic, Middle Aged, confounding, Hospitalization, Observational Studies as Topic, Italy, Research Design, fracture, Case-Control Studies, Female
Abstract

Purpose: Different strategies applicable to control for confounding by indication in observational studies were compared in a large population-based study regarding the effect of bisphosphonates (BPs) for secondary prevention of fractures. Methods: The cohort was drawn from healthcare utilization databases of 13 Italian territorial units. Patients aged 55years or more who were hospitalized for fracture during 2003-2005 entered into the cohort. A nested case-control design was used to compare BPs use in cohort members who did (cases) and who did not experience (controls) a new fracture until 2007 (outcome). Three designs were employed: conventional-matching (D1), propensity score-matching (D2), and user-only (D3) designs. They differed for (i) cohort composition, restricted to patients who received BPs straight after cohort entry (D3); (ii) using propensity score for case-control matching (D2); and (iii) compared groups of BPs users versus no users (D1 and D2) and long-term versus short-term users (D3). Results: Bisphosphonate users had odds ratios (95% confidence interval) of 1.20 (1.01 to 1.44) and 0.95 (0.74 to 1.24) by applying D1 and D2 designs, respectively. Statistical evidence that long-term BPs use protects the outcome onset with respect to short-term use was observed for user-only design (D3) being the corresponding odds ratio (95% confidence interval) 0.64 (0.44 to 0.93). Conclusions: User-only design yielded closer results to those seen in RCTs. This approach is one possible strategy to account for confounding by indication. © 2014 John Wiley & Sons, Ltd.

Published
2014

30. Effectiveness of oral bisphosphonates for primary prevention of osteoporotic fractures: evidence from the AIFA-BEST observational study

Author

Ghirardi, A, Di Bari, M, Zambon, A, Scotti, L, Della Vedova, G, Lapi, F, Cipriani, F, Caputi, Ap, Vaccheri, A, Gregori, D, Gesuita, R, Vestri, A, Staniscia, T, Mazzaglia, G, Corrao, G, Best, Investigators, Valenti, Marco, Ghirardi, A, Di Bari, M, Zambon, A, Scotti, L, DELLA VEDOVA, G, Lapi, F, Cipriani, F, Caputi, A, Vaccheri, A, Gregori, D, Gesuita, R, Vestri, A, Staniscia, T, Mazzaglia, G, Corrao, G, Best, I, Ghirardi A, Di Bari M, Zambon A, Scotti L, Della Vedova G, Lapi F, Cipriani F, Caputi AP, Vaccheri A, Gregori D, Gesuita R, Vestri A, Staniscia T, Mazzaglia G, Corrao G, and BEST investigators

Subjects
medicine.medical_specialty, Pediatrics, Osteoporosis, Dentistry, Database, Databases, Primary prevention, Fracture prevention, Odds Ratio, Humans, Medicine, Bisphosphonate, Pharmacology (medical), Bisphosphonates, Nested case-control, Bone Density Conservation Agents, Case-Control Studies, Diphosphonates, Italy, Middle Aged, Osteoporotic Fractures, Primary Prevention, Treatment Outcome, Pharmacology, MED/01 - STATISTICA MEDICA, business.industry, Incidence (epidemiology), Public health, Osteoporosi, General Medicine, Odds ratio, medicine.disease, Confidence interval, Nested case-control study, Observational study, business
Abstract

Purpose: Osteoporosis is a chronic disease of the bone, whose incidence increases progressively with aging. The main consequences of osteoporosis are fragility fractures, which have considerable medical, social, and economic implications. Adequate treatment of osteoporosis must be considered as a compelling public health intervention. Bisphosphonates (BPs) represent the most significant advance in this field in the past decade, and they are widely used in the treatment of osteoporosis. However, evidence for their effectiveness is limited to secondary prevention, whereas their effect in primary prevention is uncertain and needs further investigation. Methods: Using administrative data collected in the "Biphosphonates Efficacy-Safety Tradeoff" (BEST) study, a nested case-control study was conducted by including 56,058 participants, aged 55 years who were started on oral BPs from 2003 to 2005. Cases were the 1,710 participants who were hospitalized for osteoporotic fractures until 2007. Up to 20 controls were randomly selected for each case. Conditional logistic regression model was used to estimate odds ratio of fracture associated with categories of treatment duration. Results: Compared with participants assuming BPs for less than 1 year, those who remained on therapy for at least 2 years had a 21 % (95 % confidence interval (CI) 7 to 33 %) fracture risk reduction. Conclusion: This study provides evidence that BPs, dispensed for primary prevention of osteoporotic fractures, are associated with a reduced risk of osteoporotic fractures after at least 2 years of treatment. © 2014 Springer-Verlag.

Published
2014

31. Effect of omiganan on colonic anastomosis healing in a rat model of peritonitis

Author

Lorenzi, T., Trombettoni, M. M. C., Ghiselli, R., Paolinelli, F., Gesuita, R., Cirioni, O., Provinciali, M., Kamysz, W., Kamysz, E., Piangatelli, C., Castellucci, M., Guerrieri, M., and Morroni, M.

Subjects
Original Article, bacterial infections and mycoses
Abstract

Background: This study investigates the effects of the antimicrobial cationic peptide omiganan-alone and combined with the antibiotic imipenem-on colonic anastomosis healing in presence of intraperitoneal sepsis induced in a rodent model of cecal ligation and puncture (CLP). Methods: Forty male Wistar rats were divided into 5 groups of 8 animals. Group 1 (control group) underwent laparotomy and cecal mobilization and the next day received left colon anastomosis. In group 2 (CLP without treatment), group 3 (CLP + imipenem), group 4 (CLP + omiganan), and group 5 (CLP + omiganan + imipenem), the left colon anastomosis was performed the day after CLP. Imipenem and omiganan were administered by intraperitoneal injection immediately before anastomosis construction and subsequently at 24 h intervals until the 7th postoperative day, when rats were sacrificed. Anastomotic bursting pressure was measured in situ. Tissue samples were collected for determination of hydroxyproline content and histological characteristics. Results: Only rats receiving omiganan + imipenem displayed re-epithelialization, reduced neovascularization of granulation tissue, and a bursting pressure that was similar to that of controls. Omiganan-alone and combined with imipenem-was associated with a better control of inflammatory parameters than imipenem alone. In addition omiganan, like imipenem, counteracted the collagen depletion typical of sepsis. Conclusions: This experimental study demonstrates the efficacy of the new antimicrobial agent omiganan, alone and in combination with imipenem, in delaying the effects of intraperitoneal sepsis on colonic anastomosis healing and provides evidence of the value of omiganan as a therapeutic agent.

Published
2017

32. Risk of severe upper gastrointestinal complications among oral bisphosphonate users

Author

Ghirardi, A, Scotti, L, Zambon, A, Della Vedova, G, Cavalieri D'Oro, L, Lapi, F, Cipriani, F, Caputi, Ap, Vaccheri, A, Gregori, D, Gesuita, R, Vestri, A, Staniscia, T, Mazzaglia, G, Corrao, G, Best, Investigators, Valenti, Marco, Ghirardi, A, Scotti, L, Zambon, A, DELLA VEDOVA, G, Cavalieri D'oro, L, Lapi, F, Cipriani, F, Caputi, A, Vaccheri, A, Gregori, D, Gesuita, R, Vestri, A, Staniscia, T, Mazzaglia, G, Corrao, G, Best, I, Ghirardi A, Scotti L, Zambon A, Della Vedova G, Cavalieri D'oro L, Lapi F, Cipriani F, Caputi AP, Vaccheri A, Gregori D, Gesuita R, Vestri A, Staniscia T, Mazzaglia G, Corrao G, and BEST Investigators

Subjects
Male, Systematic error, medicine.medical_specialty, Logistic Model, Gastrointestinal Diseases, Gastrointestinal Disease, Osteoporosis, lcsh:Medicine, Administration, Oral, Internal medicine, Odds Ratio, Humans, Medicine, Upper gastrointestinal, lcsh:Science, Adverse effect, Bphosphonate, MED/01 - STATISTICA MEDICA, Aged, Aged, 80 and over, Multidisciplinary, Oral bisphosphonates, Bone Density Conservation Agents, Diphosphonates, business.industry, lcsh:R, Case-control study, Odds ratio, Middle Aged, medicine.disease, severe upper gastrointestinal complications, nested case-control study, oral bisphosphonates, Surgery, Administration, Oral, Aged, Aged, 80 and over, Bone Density Conservation Agents, administration /&/ dosage/adverse effects/therapeutic use, Diphosphonates, administration /&/ dosage/adverse effects/therapeutic use, Female, Gastrointestinal Diseases, chemically induced, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Osteoporosis, drug therapy, ontrol Studies, Regimen, Logistic Models, Case-Control Studies, Bisphosphonates, Drug safety, Healthcare utilization database, Upper gastrointestinal complications, lcsh:Q, Female, Case-Control Studie, business, Research Article
Abstract

Background Oral bisphosphonates (BPs) are the primary agents for the treatment of osteoporosis. Although BPs are generally well tolerated, serious gastrointestinal adverse events have been observed. Aim To assess the risk of severe upper gastrointestinal complications (UGIC) among BP users by means of a large study based on a network of Italian healthcare utilization databases. Methods A nested case-control study was carried out by including 110,220 patients aged 45 years or older who, from 2003 until 2005, were treated with oral BPs. Cases were the 862 patients who experienced the outcome (hospitalization for UGIC) until 2007. Up to 20 controls were randomly selected for each case. Conditional logistic regression model was used to estimate odds ratio (OR) associated with current use of BPs after adjusting for several covariates. A set of sensitivity analyses was performed in order to account for sources of systematic uncertainty. Results The adjusted OR for current use of BPs with respect to past use was 0.94 (95% CI 0.81 to 1.08). There was no evidence that this risk changed either with BP type and regimen, or concurrent use of other drugs or previous hospitalizations. Conclusions No evidence was found that current use of BPs increases the risk of severe upper gastrointestinal complications compared to past use.

Published
2013

33. Health-related quality of life and treatment preferences in adolescents with type 1 diabetes. The VIPKIDS study

Author

Cherubini V, Gesuita R, Bonfanti R, Frongia AP, Iafusco D, Iannilli A, Lombardo F, Rabbone I, Sabbion A, Salvatoni A, Scaramuzza A, Schiaffini R, Sulli N, Toni S, Tumini S, Mosca A, Carle F, VIPKIDS Study G.r.o.u.p., FRANZESE, ADRIANA, Cherubini, V, Gesuita, R, Bonfanti, R, Franzese, Adriana, Frongia, Ap, Iafusco, D, Iannilli, A, Lombardo, F, Rabbone, I, Sabbion, A, Salvatoni, A, Scaramuzza, A, Schiaffini, R, Sulli, N, Toni, S, Tumini, S, Mosca, A, Carle, F, VIPKIDS Study, G. r. o. u. p., Franzese, A, Iafusco, Dario, and VIPKIDS Study, Group

Subjects
Male, medicine.medical_specialty, Pediatrics, Activities of daily living, Adolescent, Health Status, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, MEDLINE, Infusions, Subcutaneous, Insulin Infusion Systems, Endocrinology, Quality of life, CSII Quality of life Diabetes in childhood. Devices Psychological aspects, Surveys and Questionnaires, Diabetes mellitus, Devices, Diabetes in childhood, Psychological aspects, Internal Medicine, medicine, Humans, Insulin, Child, Health related quality of life, Type 1 diabetes, business.industry, Reproducibility of Results, Patient Preference, General Medicine, medicine.disease, humanities, Diabetes Mellitus, Type 1, Quality of Life, Physical therapy, Female, Observational study, business
Abstract

A multi-centre, observational, cross-sectional study was carried out to determine whether the healthrelated quality of life (HRQOL) of adolescents with type 1 diabetes is affected by different insulin treatment systems, and which features of HRQOL are impacted by the respective insulin treatment. The study regarded 577 adolescents, aged 10–17 years, with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) (n = 306) or multiple daily injections (MDI) (n = 271). The Insulin Delivery System Rating Questionnaire was validated in Italian and was self-completed by the subjects during a routine visit to the centres. Subjects were compared following the domains of the questionnaire. Good HRQOL was seen in subjects treated with either MDI or CSII. Significant differences were not found in the domains for general diabetes, including diabetes worries, social burden and psychological well-being. Multiple quantile regression analysis showed that CSII confers significant advantages in terms of HRQOL with improvements in treatment satisfaction, perceived clinical efficacy and reduction in treatment interference with daily activities.This favourable impact was more evident in subjects reporting lower HRQOL scores, suggesting that CSII may be especially useful for individuals perceiving a poor HRQOL. Analysis of the domains indicated that CSII was associated with a higher HRQOL than MDI. Life-course HRQOL evaluation using a standardised questionnaire can ensure better chronic disease management. This is particularly important when providing individualized care for adolescents, as they become increasingly responsible for managing their diabetes.

Published
2014

35. Epidemiology of diabetic ketoacidosis in Italy

Author

Cherubini, V, Gesuita, R, Sternardi, S, Ferrito, L, Lenzi, L, Iannilli, A, Piccini, B, Skrami, E, Nicolucci, A, Pintaudi, B, Toni, S, Lera, R, De Luna, L, Kienberger, B, Gualtieri, A, Zecchino, C, Piccino, E, Ortolani, F, Zucchini, S, Maltoni, G, Pasquino, B, Reinstadler, P, Prandi, E, Zattoni, V, Gallo, F, Morganti, G, Guerraggio, L, Ripoli, C, Frongia, M, Pusceddu, P, La Loggia, A, Scanu, P, Cardinale, G, Ponzi, G, Tomaselli, L, G, Rapisarda, V, Citriniti, F, Soprani, T, Tumini, S, Lazzaro, N, De Donno, V, Banin, P, Mainetti, B, Coccioli, Ms, D'Annunzio, G, Minuto, N, Montani, E, Maccioni, R, Marongiu, U, Beccaria, L, Bruzzese, M, Mammì, F, Pardi, D, Lombardo, F, Ventrici, C, Scaramazza, A, Ferrari, M, Bonfanti, R, Rigamonti, A, Iughetti, L, Predieri, B, Iafusco, D, Confetto, S, Zanfardino, A, Prisco, F, Franzese, A, De Nitto, E, Cadario, F, Milia, A, Piredda, G, Mereu, L, Soro, M, Correddu, A, Pipia, A, Monciotti, C, Cardella, F, De Berardinis, F, Santoro, G, Chiari, G, Berioli, M, Federico, G, Zanette, G, Marsciani, A, Pedini, A, Patera, I, P, Schiaffini, R, Bitti, M, Lidano, R, Pietrosanti, S, Delvecchio, M, Trada, M, Marinaro, A, Meloni, G, Galero, A, Fichera, G, Bulciolu, P, Rabbone, I, Ignaccolo, G, Cauvin, V, Franceschi, R, Faleschini, E, Tornese, G, Salvatoni, Alessandro, Cardani, R, Maffeis, C, Marigliano, M, Sabbion, A, and Arnaldi, C.

Published
2014

37. Diabetes Incidence in 0- to 14-Year Age-Group in Italy

Author

CARLE F, GESUITA R, BRUNO G, COPPA GV, FALORNI A, LORINI R, MARTINUCCI ME, POZZILLI P, PRISCO F, SONGINI M, TENCONI MT, CHERUBINI V, THE RIDI STUDY GROUP, PIFFER S, FRANCHINI S, BIANCHI L, CERUTTI F, MERLETTI F, PAGANO G, COTELLESSA M, MINICUCCI L, BARBIERI P, D’ANNUNZIO G, BAZZANO S, TONI S, REALI MS, MEDICI A, IUGHETTI L, PREDIERI B, BALLI F, VISALLI N, SEBASTIANI L, MARIETTI G, SANTEUSANIO F, DE GIORGI G, SANTILLI E, IANNILLI A, PINELLI A, MASCIOLI G, ALTOBELLI E, CHIARELLI F, TUMINI S, IAFUSCO D, DE FELICE E, INGENITO N, CASU A, FRONGIA P, MARINARO A., DEVOTI, Gabriele, Carle, F, Gesuita, R, Bruno, G, Coppa, Gv, Falorni, A, Lorini, R, Martinucci, Me, Pozzilli, P, Prisco, F, Songini, M, Tenconi, Mt, Cherubini, V, THE RIDI STUDY, Group, Piffer, S, Franchini, S, Bianchi, L, Cerutti, F, Merletti, F, Pagano, G, Cotellessa, M, Minicucci, L, Barbieri, P, Devoti, Gabriele, D’Annunzio, G, Bazzano, S, Toni, S, Reali, M, Medici, A, Iughetti, L, Predieri, B, Balli, F, Visalli, N, Sebastiani, L, Marietti, G, Santeusanio, F, DE GIORGI, G, Santilli, E, Iannilli, A, Pinelli, A, Mascioli, G, Altobelli, E, Chiarelli, F, Tumini, S, Iafusco, D, DE FELICE, E, Ingenito, N, Casu, A, Frongia, P, and Marinaro, A.

Subjects
incidence, registry, Type 1 diabetes mellitu
Abstract

Objective. The Registry for Type 1 Diabetes Mellitus in Italy (RIDI) Study Group was established to coordinate the registries of type 1 diabetes in Italy. This report is based on 3,606 children younger than 15 years diagnosed with type 1 diabetes and prospectively registered during 1990-1999 by nine centers, covering > 35% of the Italian population. Research design and methods. Registries were pooled in four geographic macro-areas: north, central, south and insular. The completeness of registration was assessed by the capture-recapture method. Poisson regression analysis was used to evaluate temporal trend in incidence. Results. Large variation in incidence were confirmed not only between Sardegna and the mainland but also among peninsular areas. In Sardegna, there was an excess of boys (the boy-to-girl incidence ratio was 1.4). The overall incidence showed average increases of 3.6% (p

Published
2004

39. 38th Annual Meeting of EASD 2002

Author

Cherubini V, Carle F, Gesuita R, Bruno G, Cotellessa M, Devoti G, Falorni A, Martinucci ME, Pinelli A, Prisco F, Sondini M, Visalli N, P Barbieri, L Carpinelli, A Casu, F Cerutti, GV Coppa, D'Annunzio G, De Giorgi G, Di Meio M, Frongia P, Gentili A, Iafusco D, A Iannilli, R Lorini, G Marietti, AM Marinaro, M Mazzella, A Medici, F Merletti, G Pagano, ML Picchio, P Pozzilli, F Santeusanio, MT Tenconi, S Toni., EASD 2002 European Association for the Study of Diabetes, Cherubini, V, Carle, F, Gesuita, R, Bruno, G, Cotellessa, M, Devoti, G, Falorni, A, Martinucci, Me, Pinelli, A, Prisco, F, Sondini, M, Visalli, N, P, Barbieri, L, Carpinelli, A, Casu, F, Cerutti, Gv, Coppa, D'Annunzio, G, De Giorgi, G, Di Meio, M, Frongia, P, Gentili, A, Iafusco, D, A, Iannilli, R, Lorini, G, Marietti, Am, Marinaro, M, Mazzella, A, Medici, F, Merletti, G, Pagano, Ml, Picchio, P, Pozzilli, F, Santeusanio, Mt, Tenconi, and S, Toni.

Abstract

Background and Aims: During the last decade several studies reported an increase in the incidence of type I diabetes mellitus (TlDM). Such increase varies among the European countries in both age groups and gender. Furthermore, in some countries a rising incidence of TI DM has been reported in children

Published
2002

40. Geographical variation and rising trend of type 1 diabetes in Italy

Author

Cherubini V, Carle F, Gesuita R, Bruno G, Cotellessa M, Devoti G, Falorni A, Martinucci ME, Pinelli A, Prisco F, Sondini M, Visalli N, RIDI Study Group (P Barbieri, L Carpinelli, A Casu, F Cerutti, GV Coppa, G D'Annunzio, G De Giorgi, M Di Meio, P Frongia, A Gentili, Iafusco D, A Iannilli, R Lorini, G Marietti, AM Marinaro, M Mazzella, A Medici, F Merletti, G Pagano, ML Picchio, P Pozzilli, F Santeusanio, MT Tenconi, S Toni. ), F. Carle, R. Gesuita, G. Bruno, M. Cotellessa, G. Devoti, A. Falorni, M. E. Martinucci, A. Pinelli, F. Prisco, M. Songini, N. Visalli, RIDI Study Group, Barbieri, L Carpinelli, A Casu, F Cerutti, GV Coppa, G D' Annunzio, G De Giorgi, M Di Meio, P Frongia, A Gentili, D Iafusco, A Iannilli, R Lorini, G Marietti, AM Marinaro, M Mazzella, A Medici, F Merletti, G Pagano, ML Picchio, P Pozzilli, F Santeusanio, MT Tenconi, S Toni., Cherubini, V, Carle, F, Gesuita, R, Bruno, G, Cotellessa, M, Devoti, G, Falorni, A, Martinucci, Me, Pinelli, A, Prisco, F, Sondini, M, Visalli, N, RIDI Study Group (P, Barbieri, L, Carpinelli, A, Casu, F, Cerutti, Gv, Coppa, G, D'Annunzio, G De, Giorgi, M Di, Meio, P, Frongia, A, Gentili, Iafusco, D, A, Iannilli, R, Lorini, G, Marietti, Am, Marinaro, M, Mazzella, A, Medici, F, Merletti, G, Pagano, Ml, Picchio, P, Pozzilli, F, Santeusanio, Mt, Tenconi, and S, Toni. ).

Published
2002

41. Assessing the risk/benefit profile of Bisphosphonates therapy in the secondary prevention of osteoporotic fractures: results from a retrospective cohort study with regional claim databases.Rapporto finale progetto AIFA

Author

Lapi, F, Sessa, E, Cipriani, F, Ghirardi, A, Scotti, L, Parosi, A, Zambon, A, Di Bari, M, Arcoraci, V, Piccinini, C, Suzzi, C, Puccini, A, Vaccheri, A, Gesuita, R, Forlan, F, Staniscia, C, Menna, A, Caputi, Ap, Corrao, G, Montanaro, N, Sturkenboom, M, Geppetti, P, Gregori, D, Carle, F, Vestri, A, Valenti, Marco, Campisi, G, Fusco, V, and Mazzaglia, G.

Published
2012

42. Incidence variation and trends of childhood type 1 diabetes in ITALY

Author

CHERUBINI V, CARLE F, GESUITA R, PINELLI A, KANTAR A, CERUTTI F, PAGANO G, BRUNO G, MAZZELLA M, BARBIERI P, LORINI R, DANNUNZIO G, TENCONI MT, FRONGIA P, CASU A, SONGINI M, VISALLI N, MARIETTI G, POZZILLI P, FALORNI A, PICCHIO MI, DE GIORGI G, PRISCO F, IAFUSCO D, INGENITO N, RIDI CO ORDINATING CENTRE, UNIVERSITY OF ANCONA, ITALY, DEVOTI, Gabriele, Cherubini, V, Carle, F, Gesuita, R, Pinelli, A, Kantar, A, Cerutti, F, Pagano, G, Bruno, G, Mazzella, M, Barbieri, P, Lorini, R, Devoti, G, D’Annunzio, G, Tenconi, Mt, Frongia, P, Casu, A, Songini, M, Visalli, N, Marietti, G, Pozzilli, P, Falorni, A, Picchio, Ml, De Giorgi, G, Prisco, F, Iafusco, Dario, Ingenito, N, ordinating Centre, RIDI C. o., University of, Ancona, Italy, Devoti, Gabriele, Dannunzio, G, Picchio, Mi, DE GIORGI, G, Iafusco, D, RIDI CO ORDINATING, Centre, and UNIVERSITY OF, Ancona

Published
2000

43. Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: the RIDI study

Author

Bruno, G, Maule, M, Merletti, F, Novelli, G, Falorni, A, Iannilli, A, Iughetti, Lorenzo, Altobelli, E, D'Annunzio, G, Piffer, S, Pozzilli, P, Iafusco, D, Songini, M, Roncarolo, F, Toni, S, Carle, F, Cherubini, V, Cerutti, F, Franchini, S, Bianchi, L, Lorini, R, Minuto, N, Sacco, S, Ramondetti, F, Predieri, Barbara, Reali, S, Medici, A, Biagioni, M, Gesuita, R, Santeusanio, F, De Giorgi, G, Visalli, N, Bizzarri, C, Chiarelli, F, Tumini, S, Prisco, F, Confetto, S, Frongia, P, and Marinaro, A.

Subjects
Cohort Studies, Type 1 diabetes, incidence
Published
2010

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