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247 results on '"Gestwicki JE"'

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1. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy

3. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis

4. An allosteric modulator of HIV-1 protease shows equipotent inhibition of wild-type and drug-resistant proteases

5. Identification of Key Hinge Residues Important for Nucleotide-Dependent Allostery in E. coli Hsp70/DnaK

6. CSAR data set release 2012: Ligands, affinities, complexes, and docking decoys

7. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

8. Recombinant Antibodies Inhibit Enzymatic Activity of the E3 Ubiquitin Ligase CHIP via Multiple Mechanisms.

9. Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes.

10. Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins.

11. Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly.

12. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.

13. O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone.

14. Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.

15. Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs.

16. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.

17. Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer.

18. Exploration of the binding determinants of protein phosphatase 5 (PP5) reveals a chaperone-independent activation mechanism.

19. Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer.

20. Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors.

21. DSFworld: A flexible and precise tool to analyze differential scanning fluorimetry data.

22. Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.

23. Plasmodium falciparum heat shock proteins as antimalarial drug targets: An update.

24. A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats.

25. Protocol for performing and optimizing differential scanning fluorimetry experiments.

26. Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy.

27. De novo designed Hsp70 activator dissolves intracellular condensates.

28. Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.

29. An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3.

30. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).

31. Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly.

32. Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer.

33. A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway.

34. Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models.

35. Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States.

36. Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry.

37. Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.

38. N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.

39. Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.

40. A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.

41. Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2.

42. Multivalent protein-protein interactions are pivotal regulators of eukaryotic Hsp70 complexes.

43. Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.

44. Multi-protein complexes as drug targets.

45. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.

46. Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer.

47. The YΦ motif defines the structure-activity relationships of human 20S proteasome activators.

48. Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities.

49. Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells.

50. End-Binding E3 Ubiquitin Ligases Enable Protease Signaling.

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