10 results on '"Gergely Daróczi"'
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2. Linguistic and cultural adaptation to the Portuguese language of antimicrobial dose adjustment software
- Author
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Samuel Dutra da Silva, Geisa Cristina da Silva Alves, Farah Maria Drumond Chequer, Andras Farkas, Gergely Daróczi, Jason A. Roberts, and Cristina Sanches
- Subjects
Software ,Dosage forms ,Anti-infective agents ,Piperacillin ,Intensive care units ,Surveys and questionnaires ,Brazil ,Medicine - Abstract
ABSTRACT Objective To adapt an antibiotic dose adjustment software initially developed in English, to Portuguese and to the Brazilian context. Methods This was an observational, descriptive study in which the Delphi method was used to establish consensus among specialists from different health areas, with questions addressing the visual and operational aspects of the software. In a second stage, a pilot experimental study was performed with the random comparison of patients for evaluation and adaptation of the software in the real environment of an intensive care unit, where it was compared between patients who used the standardized dose of piperacillin/tazobactam, and those who used an individualized dose adjusted through the software Individually Designed and Optimized Dosing Strategies. Results Twelve professionals participated in the first round, whose suggestions were forwarded to the software developer for adjustments, and subsequently submitted to the second round. Eight specialists participated in the second round. Indexes of 80% and 90% of concordance were obtained between the judges, characterizing uniformity in the suggestions. Thus, there was modification in the layout of the software for linguistic and cultural adequacy, minimizing errors of understanding and contradictions. In the second stage, 21 patients were included, and there were no differences between doses of piperacillin in the standard dose and adjusted dose Groups. Conclusion The adapted version of the software is safe and reliable for its use in Brazil.
- Published
- 2020
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3. Creating statistical reports in the past, present and future
- Author
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Gergely Daróczi
- Subjects
literate programming ,reports ,reproducible research ,Statistics ,HA1-4737 - Abstract
The paper summarizes the most important milestones in the recent history of computer-aided data analysis, then suggests an alternative reporting workflow to the traditional statistical software methods by the means of an R package implementing statistical report templates with annotations in plain English.
- Published
- 2014
4. Software for dose adjustment of antimicrobials. Implications for plasma concentrations and pratical limitations
- Author
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André Oliveira Baldoni, Whocely Victor de Castro, Andras Farkas, Jason A. Roberts, Geisa Cristina da Silva Alves, Samuel Dutra da Silva, Cristina Sanches, Gergely Daróczi, and Farah Maria Drumond Chequer
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,General Medicine ,Drug Dosage Calculation ,03 medical and health sciences ,0302 clinical medicine ,Anti-Infective Agents ,Dose adjustment ,030220 oncology & carcinogenesis ,Plasma concentration ,Medicine ,Carta Ao Editor ,Humans ,Drug Dosage Calculations ,030212 general & internal medicine ,business ,Letter to the Editor ,Software - Abstract
Caro Editor, Esta carta visa complementar os dados publicados por Silva et al., ( ) apresentando os resultados das concentracoes plasmaticas de pacientes que utilizaram piperacilina (PIP) em dose empirica (DE) ou dose ajustada (DA) pelo software Optimum Dosing Strategies (ID-ODS), alem de expor alguns pontos limitadores observados pelos autores durante a utilizacao do software na realidade de um hospital brasileiro. […] Software para ajuste de doses de antimicrobianos. Implicacoes nas concentracoes plasmaticas e limitacoes praticas
- Published
- 2020
5. The Rockerverse: Packages and Applications for Containerization with R
- Author
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Dirk Eddelbuettel, Charlotte Van Petegem, Noam Ross, Colin Fay, Jacqueline Nolis, Nan Xiao, Hong Ooi, Mark Edmondson, Jason Williams, Ellis Hughes, Lori Shepherd, Péter Sólymos, Tyson L. Swetnam, Lars Kjeldgaard, Sean Lopp, Karthik Ram, Ben Marwick, Craig Willis, Heather Nolis, Gergely Daróczi, Nitesh Turaga, Robrecht Cannoodt, Dav Clark, Dom Bennett, and Daniel Nüst
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Statistics and Probability ,FOS: Computer and information sciences ,Technology and Engineering ,Downstream (software development) ,Computer science ,FEATURES ,Cloud computing ,02 engineering and technology ,K.6.3 ,050105 experimental psychology ,Software portability ,Computer Science - Software Engineering ,Software ,0202 electrical engineering, electronic engineering, information engineering ,0501 psychology and cognitive sciences ,Use case ,D.2.6 ,D.2.7 ,Numerical Analysis ,business.industry ,68N01 ,Statistics ,05 social sciences ,020206 networking & telecommunications ,Data science ,Variety (cybernetics) ,DOCKER ,Software Engineering (cs.SE) ,Computer Science - Distributed, Parallel, and Cluster Computing ,Software deployment ,REPLICATION ,Scalability ,Probability and Uncertainty ,Distributed, Parallel, and Cluster Computing (cs.DC) ,Statistics, Probability and Uncertainty ,business - Abstract
The Rocker Project provides widely used Docker images for R across different application scenarios. This article surveys downstream projects that build upon the Rocker Project images and presents the current state of R packages for managing Docker images and controlling containers. These use cases cover diverse topics such as package development, reproducible research, collaborative work, cloud-based data processing, and production deployment of services. The variety of applications demonstrates the power of the Rocker Project specifically and containerisation in general. Across the diverse ways to use containers, we identified common themes: reproducible environments, scalability and efficiency, and portability across clouds. We conclude that the current growth and diversification of use cases is likely to continue its positive impact, but see the need for consolidating the Rockerverse ecosystem of packages, developing common practices for applications, and exploring alternative containerisation software., Source code for article available at https://github.com/nuest/rockerverse-paper/ Updated version includes some new paragraphs and corrections throughout the text; full diff available at https://github.com/nuest/rockerverse-paper/compare/preprint.v2...preprint.v3
- Published
- 2020
6. Linguistic and cultural adaptation to the Portuguese language of antimicrobial dose adjustment software
- Author
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Andras Farkas, Geisa Cristina da Silva Alves, Jason A. Roberts, Gergely Daróczi, Farah Maria Drumond Chequer, Samuel Dutra da Silva, and Cristina Sanches
- Subjects
Male ,Delphi Technique ,Delphi method ,0302 clinical medicine ,Software ,Anti-Infective Agents ,Software Design ,Surveys and Questionnaires ,Medicine ,030212 general & internal medicine ,Dosage forms ,Aged, 80 and over ,Anti-infecciosos ,Intensive care units ,Anthropometry ,Artigo Original ,General Medicine ,Middle Aged ,Reference Standards ,Piperacilina ,Linguistics ,Inquéritos e questionários ,030220 oncology & carcinogenesis ,language ,Software design ,Anti-infective agents ,Original Article ,Female ,Brazil ,Cross-Cultural Comparison ,Tazobactam ,Concordance ,Context (language use) ,Statistics, Nonparametric ,03 medical and health sciences ,Humans ,Adaptation (computer science) ,Aged ,Piperacillin ,business.industry ,Brasil ,Formas de dosagem ,Reproducibility of Results ,language.human_language ,Unidades de terapia intensiva ,Observational study ,Portuguese ,business ,Surveys and questionnaires - Abstract
Objective To adapt an antibiotic dose adjustment software initially developed in English, to Portuguese and to the Brazilian context. Methods This was an observational, descriptive study in which the Delphi method was used to establish consensus among specialists from different health areas, with questions addressing the visual and operational aspects of the software. In a second stage, a pilot experimental study was performed with the random comparison of patients for evaluation and adaptation of the software in the real environment of an intensive care unit, where it was compared between patients who used the standardized dose of piperacillin/tazobactam, and those who used an individualized dose adjusted through the software Individually Designed and Optimized Dosing Strategies. Results Twelve professionals participated in the first round, whose suggestions were forwarded to the software developer for adjustments, and subsequently submitted to the second round. Eight specialists participated in the second round. Indexes of 80% and 90% of concordance were obtained between the judges, characterizing uniformity in the suggestions. Thus, there was modification in the layout of the software for linguistic and cultural adequacy, minimizing errors of understanding and contradictions. In the second stage, 21 patients were included, and there were no differences between doses of piperacillin in the standard dose and adjusted dose Groups. Conclusion The adapted version of the software is safe and reliable for its use in Brazil.
- Published
- 2020
7. 1545. Development of a Linear Mixed-Effect Pharmacodynamic Model to Quantify the Effects of Frequently Prescribed Antimicrobials on QT Interval Prolongation in Hospitalized Patients
- Author
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Christian Olivo Freites, Francesco Ciummo, Arsheena Yassin, Joseph Sassine, Gergely Daróczi, Ami Shah, Andras Farkas, and Krystina L Woods
- Subjects
medicine.medical_specialty ,business.industry ,Prolongation ,Torsades de pointes ,Azithromycin ,medicine.disease ,QT interval ,Abstracts ,Infectious Diseases ,Oncology ,Levofloxacin ,Pharmacodynamics ,Internal medicine ,Poster Abstracts ,Mixed effects ,Medicine ,business ,Fluconazole ,medicine.drug - Abstract
Background Torsades de pointes is a life-threatening ventricular tachycardia associated with prolongation of the QT interval. Many diseases and medications have been implicated as potentially prolonging the QT interval, but little data exists regarding the means of quantifying this risk. The aim of this study was to describe the impact of commonly used antimicrobials on the QT interval in hospitalized patients. Methods Demographic, diseases, laboratory, medication administration history and ECG recording data were collected from the electronic records of adult patients admitted, from July 2018 to December 2018, to two urban hospitals. A model for the QT interval comprised of four sub-models: gender, heart rate, circadian rhythm, and the drug and disease effects. Fixed and random effects with between occasion variability were estimated for the parameters. A Bayesian approach using the NUTS in STAN was used via the brms package in the R® software. Results Data from 1,353 patients were used with baseline characteristics shown in Table 1. Observed vs. predicted plots based on the training (Figure 1A) and validation data set (Figure 1B) showed a great fit. The parameters for QTc0, α, gender, and circadian rhythm were accurately identified (Table 2). Similarly, the model correctly described the expected impact of acute or chronic diseases on the QT interval. Uncertainty interval estimates (Figure 2) show that patients treated with fluconazole and levofloxacin are likely to present with a QT interval [mean (95% CI) of 6.84 (0.22,21.45) and 5.05 (0.15, 16.70), respectively], that is > 5 ms longer vs. no treatment, the minimum cutoff that should evoke further risk assessment of QT interval prolongation. Conclusion The model developed correctly describes the impact baseline risk factors have on the QT interval. Point estimates of QT interval prolongation show that patients treated with fluconazole and levofloxacin may be at considerable risk; while those treated with azithromycin or ciprofloxacin are more likely to be at an insignificant risk for QT interval prolongation during hospital admission. Further workup to quantify the impact of concomitant treatment with these and other at-risk medications is underway. Disclosures All authors: No reported disclosures.
- Published
- 2019
8. R: Data Analysis and Visualization
- Author
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Tony Fischetti, Brett Lantz, Jaynal Abedin, Hrishi V. Mittal, Bater Makhabel, Edina Berlinger, Ferenc Illes, Milan Badics, Adam Banai, Gergely Daroczi, Barbara Domotor, Gergely Gabler, Daniel Havran, Peter Juhasz, Istvan Margitai, Balazs Markus, Peter Medvegyev, Julia Molnar, Balazs Arpad Szucs, Agnes Tuza, Tamas Vadasz, Kata Varadi, Agnes Vidovics-Dancs, Tony Fischetti, Brett Lantz, Jaynal Abedin, Hrishi V. Mittal, Bater Makhabel, Edina Berlinger, Ferenc Illes, Milan Badics, Adam Banai, Gergely Daroczi, Barbara Domotor, Gergely Gabler, Daniel Havran, Peter Juhasz, Istvan Margitai, Balazs Markus, Peter Medvegyev, Julia Molnar, Balazs Arpad Szucs, Agnes Tuza, Tamas Vadasz, Kata Varadi, and Agnes Vidovics-Dancs
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- R (Computer program language), Information visualization
- Abstract
Master the art of building analytical models using R. About This Book Load, wrangle, and analyze your data using the world's most powerful statistical programming language Build and customize publication-quality visualizations of powerful and stunning R graphs Develop key skills and techniques with R to create and customize data mining algorithms Use R to optimize your trading strategy and build up your own risk management system Discover how to build machine learning algorithms, prepare data, and dig deep into data prediction techniques with RWho This Book Is For This course is for data scientist or quantitative analyst who are looking at learning R and take advantage of its powerful analytical design framework. It's a seamless journey in becoming a full-stack R developer. What You Will Learn Describe and visualize the behavior of data and relationships between data Gain a thorough understanding of statistical reasoning and sampling Handle missing data gracefully using multiple imputation Create diverse types of bar charts using the default R functions Familiarize yourself with algorithms written in R for spatial data mining, text mining, and so on Understand relationships between market factors and their impact on your portfolio Harness the power of R to build machine learning algorithms with real-world data science applications Learn specialized machine learning techniques for text mining, big data, and moreIn Detail The R learning path created for you has five connected modules, which are a mini-course in their own right. As you complete each one, you'll have gained key skills and be ready for the material in the next module! This course begins by looking at the Data Analysis with R module. This will help you navigate the R environment. You'll gain a thorough understanding of statistical reasoning and sampling. Finally, you'll be able to put best practices into effect to make your job easier and facilitate reproducibility. The second place to explore is R Graphs, which will help you leverage powerful default R graphics and utilize advanced graphics systems such as lattice and ggplot2, the grammar of graphics. You'll learn how to produce, customize, and publish advanced visualizations using this popular and powerful framework. With the third module, Learning Data Mining with R, you will learn how to manipulate data with R using code snippets and be introduced to mining frequent patterns, association, and correlations while working with R programs. The Mastering R for Quantitative Finance module pragmatically introduces both the quantitative finance concepts and their modeling in R, enabling you to build a tailor-made trading system on your own. By the end of the module, you will be well-versed with various financial techniques using R and will be able to place good bets while making financial decisions. Finally, we'll look at the Machine Learning with R module. With this module, you'll discover all the analytical tools you need to gain insights from complex data and learn how to choose the correct algorithm for your specific needs. You'll also learn to apply machine learning methods to deal with common tasks, including classification, prediction, forecasting, and so on. Style and approach Learn data analysis, data visualization techniques, data mining, and machine learning all using R and also learn to build models in quantitative finance using this powerful language.
- Published
- 2016
9. Mastering Data Analysis with R : Gain Sharp Insights Into Your Data and Solve Real-world Data Science Problems with R—from Data Munging to Modeling and Visualization
- Author
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Gergely Daróczi and Gergely Daróczi
- Subjects
- R (Computer program language), Statistics--Data processing
- Abstract
Gain sharp insights into your data and solve real-world data science problems with R—from data munging to modeling and visualizationKey FeaturesBook DescriptionGain sharp insights into your data and solve real-world data science problems with R—from data munging to modeling and visualization About This Book Handle your data with precision and care for optimal business intelligence Restructure and transform your data to inform decision-making Packed with practical advice and tips to help you get to grips with data mining Who This Book Is For If you are a data scientist or R developer who wants to explore and optimize your use of R's advanced features and tools, this is the book for you. A basic knowledge of R is required, along with an understanding of database logic. What You Will Learn Connect to and load data from R's range of powerful databases Successfully fetch and parse structured and unstructured data Transform and restructure your data with efficient R packages Define and build complex statistical models with glm Develop and train machine learning algorithms Visualize social networks and graph data Deploy supervised and unsupervised classification algorithms Discover how to visualize spatial data with R In Detail R is an essential language for sharp and successful data analysis. Its numerous features and ease of use make it a powerful way of mining, managing, and interpreting large sets of data. In a world where understanding big data has become key, by mastering R you will be able to deal with your data effectively and efficiently. This book will give you the guidance you need to build and develop your knowledge and expertise. Bridging the gap between theory and practice, this book will help you to understand and use data for a competitive advantage. Beginning with taking you through essential data mining and management tasks such as munging, fetching, cleaning, and restructuring, the book then explores different model designs and the core components of effective analysis. You will then discover how to optimize your use of machine learning algorithms for classification and recommendation systems beside the traditional and more recent statistical methods. Style and approach Covering the essential tasks and skills within data science, Mastering Data Analysis provides you with solutions to the challenges of data science. Each section gives you a theoretical overview before demonstrating how to put the theory to work with real-world use cases and hands-on examples.What you will learnWho this book is for
- Published
- 2015
10. Introduction to R for Quantitative Finance : R Is a Statistical Computing Language That's Ideal for Answering Quantitative Finance Questions. This Book Gives You Both Theory and Practice, All in Clear Language with Stacks of Real-world Examples. Ideal for R Beginners or Expert Alike.
- Author
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Gergely Daróczi, Michael Phule, Edina Berlinger (EURO), Peter Csoka, Daniel Daniel Havran, Marton Michaletzky, Zsolt Tulassay, Kata Váradi, Agnes Vidovics-Dancs, Agnes Vidovics Dancs, Gergely Daróczi, Michael Phule, Edina Berlinger (EURO), Peter Csoka, Daniel Daniel Havran, Marton Michaletzky, Zsolt Tulassay, Kata Váradi, Agnes Vidovics-Dancs, and Agnes Vidovics Dancs
- Subjects
- Finance--Data processing, R (Computer program language), Finance--Mathematical models--Data processing
- Abstract
R is a statistical computing language that s ideal for answering quantitative finance questions. This book gives you both theory and practice, all in clear language with stacks of real-world examples. Ideal for R beginners or expert alike.Key FeaturesUse time series analysis to model and forecast house pricesEstimate the term structure of interest rates using prices of government bondsDetect systemically important financial institutions by employing financial network analysisBook DescriptionIntroduction to R for Quantitative Finance will show you how to solve real-world quantitative fi nance problems using the statistical computing language R. The book covers diverse topics ranging from time series analysis to fi nancial networks. Each chapter briefl y presents the theory behind specific concepts and deals with solving a diverse range of problems using R with the help of practical examples.This book will be your guide on how to use and master R in order to solve quantitative finance problems. This book covers the essentials of quantitative finance, taking you through a number of clear and practical examples in R that will not only help you to understand the theory, but how to effectively deal with your own real-life problems.Starting with time series analysis, you will also learn how to optimize portfolios and how asset pricing models work. The book then covers fixed income securities and derivatives such as credit risk management.What you will learnHow to model and forecast house prices and improve hedge ratios using cointegration and model volatilityHow to understand the theory behind portfolio selection and how it can be applied to real-world dataHow to utilize the Capital Asset Pricing Model and the Arbitrage Pricing TheoryHow to understand the basics of fixed income instrumentsYou will discover how to use discrete- and continuous-time models for pricing derivative securitiesHow to successfully work with credit default models and how to model correlated defaults using copulasHow to understand the uses of the Extreme Value Theory in insurance and fi nance, model fitting, and risk measure calculationWho this book is forIf you are looking to use R to solve problems in quantitative finance, then this book is for you. A basic knowledge of financial theory is assumed, but familiarity with R is not required. With a focus on using R to solve a wide range of issues, this book provides useful content for both the R beginner and more experience users.
- Published
- 2013
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