23 results on '"Geissler, Wayne M."'
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2. Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants
3. Modeling aided design of potent glycogen phosphorylase inhibitors
4. Amino acid substitution of arginine 80 in 17β-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics
5. Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization.
6. Development of a novel tricyclic class of potent and selective FIXa inhibitors
7. Development of a novel class of potent and selective FIXa inhibitors
8. Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors
9. A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation
10. A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes
11. The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
12. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
13. Novel 3,4-Dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a
14. Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase.
15. Expression, purification and crystallization of human prolylcarboxypeptidase.
16. Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors
17. A new class of glycogen phosphorylase inhibitors
18. Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3.
19. Novel 3,4-Dihydroquinolin-2(1H)-one Inhibitors of Human Glycogen Phosphorylase a.
20. Glucose-Lowering in a db/db Mouse Model by Dihydropyridine Diacid Glycogen Phosphorylase Inhibitors.
21. Enzymatic preparation of high-specific-activity β-d-[6,6′-3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase
22. Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
23. Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
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