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5. Prebiotic fibre mixtures counteract the manifestation of gut microbial dysbiosis induced by the chemotherapeutic 5-Fluorouracil (5-FU) in a validated in vitro model of the colon

Author

Ziemons, Janine, Hillege, Lars E., Aarnoutse, Romy, de Vos-Geelen, Judith, Valkenburg-van Iersel, Liselot, Mastenbroek, Jasper, van Geel, Robin, Barnett, David J. M., Rensen, Sander S., van Helvoort, Ardy, Dopheide, Lotte H. J., Roeselers, Guus, Penders, John, Smidt, Marjolein L., and Venema, Koen

Published
2024
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7. Longitudinal associations of diurnal rest-activity rhythms with fatigue, insomnia, and health-related quality of life in survivors of colorectal cancer up to 5 years post-treatment

Author

Chong, Marvin Y., Frenken, Koen G., Eussen, Simone J. P. M., Koster, Annemarie, Pot, Gerda K., Breukink, Stéphanie O., Janssen-Heijnen, Maryska, Keulen, Eric T. P., Bijnens, Wouter, Buffart, Laurien M., Meijer, Kenneth, Scheer, Frank A. J. L., Steindorf, Karen, de Vos-Geelen, Judith, Weijenberg, Matty P., van Roekel, Eline H., and Bours, Martijn J. L.

Published
2024
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8. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Author

Junk, Lukas, Schmiedel, Volker M., Guha, Somraj, Fischel, Katharina, Greb, Peter, Vill, Kristin, Krisilia, Violetta, van Geelen, Lasse, Rumpel, Klaus, Kaur, Parvinder, Krishnamurthy, Ramya V., Narayanan, Shridhar, Shandil, Radha Krishan, Singh, Mayas, Kofink, Christiane, Mantoulidis, Andreas, Biber, Philipp, Gmaschitz, Gerhard, Kazmaier, Uli, Meinhart, Anton, Leodolter, Julia, Hoi, David, Junker, Sabryna, Morreale, Francesca Ester, Clausen, Tim, Kalscheuer, Rainer, Weinstabl, Harald, and Boehmelt, Guido

Published
2024
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9. The peri-germ cell membrane: poorly characterized but key interface for plant reproduction

Author

Sugi, Naoya, Calhau, Andrea R. M., Jacquier, Nathanaël M. A., Millan-Blanquez, Marina, Becker, Jörg D., Begcy, Kevin, Berger, Frédéric, Bousquet-Antonelli, Cécile, Bouyer, Daniel, Cai, Giampiero, Cheung, Alice Y., Coimbra, Sílvia, Denninger, Philipp, Dresselhaus, Thomas, Feijó, José A., Fowler, John E., Geelen, Danny, Grossniklaus, Ueli, Higashiyama, Tetsuya, Honys, David, Igawa, Tomoko, Ingram, Gwyneth, Jaillais, Yvon, Johnson, Mark A., Kato, Mariko, Kawachi, Miki, Kawashima, Tomokazu, Kim, Yu-Jin, Li, Hong-Ju, Mongrand, Sébastien, Motomura, Kazuki, Nagahara, Shiori, Nakajima, Kohdai P., Nelms, Brad, Qu, Li-Jia, Schnittger, Arp, Scholten, Stefan, Sprunck, Stefanie, Sun, Meng-Xiang, Twell, David, Weijers, Dolf, Yang, Wei-Cai, Maruyama, Daisuke, and Widiez, Thomas

Published
2024
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14. The Experience Sampling Method in Small Fiber Neuropathy: The Influence of Psychosocial Factors on Pain Intensity and Physical Activity

Author

Damci A, Hoeijmakers JG, den Hollander M, Faber CG, Waardenburg S, van Laake-Geelen CCM, Köke AJ, and Verbunt JA

Subjects
chronic pain, rehabilitation therapy, biopsychosocial factors, small fiber neuropathy, Medicine (General), R5-920
Abstract

Aysun Damci,1,2 Janneke GJ Hoeijmakers,1,2 Marlies den Hollander,3– 5 Catharina G Faber,1,2 Sophie Waardenburg,6,7 Charlotte CM van Laake-Geelen,3– 5 Albère JA Köke,3,4 Jeanine AMCF Verbunt3– 5 1MHeNS, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, 6200 MD, The Netherlands; 2Department of Neurology, Maastricht University Medical Center+, Maastricht, 6229 HX, The Netherlands; 3Care and Public Health Research Institute, Maastricht university, Maastricht, 6200 MD, The Netherlands; 4Department of Rehabilitation Medicine, Maastricht University Medical Center+, Maastricht, 6229 HX, The Netherlands; 5Adelante Zorggroep, Center of Rehabilitation Medicine, Hoensbroek, 6432 CC, The Netherlands; 6Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, Maastricht, 6229 HX, The Netherlands; 7Department of Anesthesiology and Pain Medicine, Maastricht University Medical Center+, Maastricht, 6229 HX, The NetherlandsCorrespondence: Aysun Damci, Department of Neurology, Maastricht University Medical Centre+, P.O. Box 5800, Maastricht, 6202 AZ, The Netherlands, Tel +31-43-3877059, Fax +31-43-3877055, Email aysun.damci@mumc.nlPurpose: Small fiber neuropathy (SFN) is characterized by neuropathic pain, associated with decreased quality of life (QOL). It remains unclear which psychosocial factors play a role in SFN. The experience sampling method (ESM) allows a profound understanding of the real-time fluctuations in reaction to events. The main goal of this study was to increase knowledge of the interrelationships between pain intensity, physical activity, and psychosocial factors in patients with SFN in daily practice over time.Patients and Methods: A prospective observational ESM study with the PsyMate© application (smart-eHealth GmbH, Luxembourg) was conducted at the Adelante location of Maastricht University Medical Center+ in the Netherlands. Participants with idiopathic SFN, older than 18 years, with an indication for rehabilitation, were included. Pain intensity, fatigue, positive and negative affect, physical activity, avoidance behavior, and pain catastrophic thoughts were incorporated into the ESM questions. Participants received 10 beep signals per day followed by the above-mentioned questions, for consecutive 7 days. The results were analyzed with linear mixed-effect models.Results: Twenty-one participants were included with a mean age of 48.24 (SD ± 13.89) years, of whom 76.2% were female. More pain (now) resulted in more physical activity (later) (a) and more physical activity (now) resulted in more pain (later) (b). The first association (a) is influenced by pain catastrophic thoughts and fatigue, and the second (b) by an increase in affective states and a lower level of avoidance behavior.Conclusion: In idiopathic SFN, pain intensity, and physical activity showed a 2-sided association, influenced by catastrophic thoughts, fatigue, affective states, and avoidance behavior.Keywords: chronic pain, rehabilitation therapy, biopsychosocial factors, small fiber neuropathy

Published
2024

15. Development of a cost-efficient automated wildlife camera network in a European Natura 2000 site

Author

W. Daniel Kissling, Julian C. Evans, Rotem Zilber, Tom D. Breeze, Stacy Shinneman, Lindy C. Schneider, Carl Chalmers, Paul Fergus, Serge Wich, and Luc H.W.T. Geelen

Subjects
API, Artificial intelligence, Biodiversity survey, Convolutional neural network, Cyberinfrastructure, Dunes, Ecology, QH540-549.5
Abstract

Modern approaches with advanced technology can automate and expand the extent and resolution of biodiversity monitoring. We present the development of an innovative system for automated wildlife monitoring in a coastal Natura 2000 nature reserve of the Netherlands with 65 wireless 4G wildlife cameras which are deployed autonomously in the field with 12 V/2A solar panels, i.e. without the need to replace batteries or manually retrieve SD cards. The cameras transmit images automatically (through a mobile network) to a sensor portal, which contains a PostgreSQL database and functionalities for automated task scheduling and data management, allowing scientists and site managers via a web interface to view images and remotely monitor sensor performance (e.g. number of uploaded files, battery status and SD card storage of cameras). The camera trap sampling design combines a grid-based sampling stratified by major habitats with the camera placement along a traditional monitoring route, and with an experimental set-up inside and outside large herbivore exclosures. This provides opportunities for studying the distribution, habitat use, activity, phenology, population structure and community composition of wildlife species and allows comparison of traditional with novel monitoring approaches. Images are transferred via application programming interfaces to external services for automated species identification and long-term data storage. A deep learning model for species identification was tested and showed promising results for identifying focal species. Furthermore, a detailed cost analysis revealed that establishment costs of the automated system are higher but the annual operating costs much lower than those for traditional camera trapping, resulting in the automated system being >40 % more cost-efficient. The developed end-to-end data pipeline demonstrates that continuous monitoring with automated wildlife camera networks is feasible and cost-efficient, with multiple benefits for extending the current monitoring methods. The system can be applied in open habitats of other nature reserves with mobile network coverage.

Published
2024
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17. Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort studyResearch in context

Author

Anne M. Gehrels, Pauline A.J. Vissers, Mirjam A.G. Sprangers, Nienke M. Fijnheer, Esther N. Pijnappel, Lydia G. van der Geest, Geert A. Cirkel, Judith de Vos-Geelen, Marjolein Y.V. Homs, Geert- Jan Creemers, Martijn W.J. Stommel, Lois A. Daamen, Marc G. Besselink, Johanna W. Wilmink, and Hanneke W.M. van Laarhoven

Subjects
Pancreatic cancer, Pancreatic adenocarcinoma, Health-related quality of life, Treatment strategies, Medicine (General), R5-920
Abstract

Summary: Background: Pancreatic adenocarcinoma (PAC) has a poor prognosis and substantially impairs health-related quality of life (HRQoL). Large studies on longitudinal HRQoL in patients with PAC, taking patient treatment into account, are lacking. This study aimed to investigate HRQoL over time in patients with PAC undergoing various treatments. Methods: This nationwide cohort study included patients diagnosed with PAC between 2015 and 2020. Data were collected from the Dutch Pancreatic Cancer Project (PACAP) and the Netherlands Cancer Registry. Patients were categorized into four groups based on treatment modality: resection (R-PAC), chemotherapy for localized disease (C-PAC), chemotherapy for metastatic disease (M1-C-PAC), and best supportive care (BSC). HRQoL was assessed using the EORTC QLQ-C30 and -PAN26 questionnaires at baseline, during treatment, and at 0–3 months and 3–6 months after treatment. Linear mixed models were used to analyze changes in HRQoL over time, with clinically relevant changes defined as a minimal mean difference of 10 points in absolute scores and reported with 95% confidence intervals. Findings: Overall, 1496 patients were included (673 [45.0%] female), of whom 675 (45.1%) in R-PAC, 319 (21.3%) in C-PAC, 340 patients (22.7%) in M1-C-PAC, and 162 (10.8%) in BSC group. In R-PAC, hepatic symptoms and health care satisfaction improved while role and social functioning deteriorated and eating related problems, side effects and fear of future health increased during treatment. In C-PAC, insomnia, pancreatic pain, hepatic symptoms decreased while diarrhea, side effects and fear of future health increased. In M1-C-PAC, pain, insomnia, pancreatic pain, hepatic symptoms, ascites and constipation decreased, sexuality improved while fear of future health and side effects increased. In BSC, hepatic symptoms decreased and flatulence increased. Interpretation: This nationwide study identified specific improvements and deteriorations in various HRQoL domains during 6 months follow-up. This information may be valuable in the clinical setting to inform patients on potential outcomes of the course of HRQoL during various treatment strategies. Funding: None.

Published
2025
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20. Fennel and other aqueous Apiaceae byproduct extracts as novel bioprotectants: Unravelling their bioactivity, working mechanism and bioactive compounds

Author

Karen De Kock, Pierfrancesco Motti, Eva Degroote, Maaike Perneel, Bart Van Droogenbroeck, Bruno P.A. Cammue, Monica Höfte, Kristof Demeestere, Sven Mangelinckx, Danny Geelen, and Tina Kyndt

Subjects
Apiaceae byproduct extracts, Broad-spectrum biopesticides, Induced resistance, Bioactivity-guided screening, Waste stream valorization, Circular economy, Plant ecology, QK900-989
Abstract

With regard to circular economy, upcycling organic waste streams to products with a biopesticidal activity represents a promising approach in integrated pest management. The current study demonstrates the induced resistance (IR) activity of seven aqueous extracts from byproducts of the Apiaceae plant family in rice to the root-knot nematode Meloidogyne graminicola. Furthermore, we unveiled that the systemic IR activity of an aqueous extract from fennel (FWE) is conserved among monocot and dicot plants and is effective against a wide range of plant pathogens as it induces resistance in rice against Pyricularia oryzae, in sugar beet against Heterodera schachtiii, in tomato against Meloidogyne incognita and in Arabidopsis against Hyaloperonospora arabidopsidis and Botrytis cinerea. The extract also showed a strong direct nematicidal activity against M. graminicola, fungicidal activity against P. oryzae and bactericidal activity against Pseudomonas syringae pv. tomato DC3000. Transcriptome analysis in combination with complementary biochemical validation in FWE-treated rice plants underlined the importance of an altered reactive oxygen species (ROS) metabolism, lignin accumulation and elevated levels of abscisic acid (ABA),indole-3-acetic acid (IAA) and jasmonic acid (JA) in FWE-treated rice plants. Lastly, bioactivity-guided fractionation and identification revealed several small organic acids such as alanine, malic acid and У-aminobutyric acid (GABA) as potential IR eliciting constituents in the extracts. To summarize, our data demonstrates high potential for valorization of Apiaceae byproduct extracts as preventive or curative plant bioprotectants in near-future eco-friendly agricultural practices.

Published
2025
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21. Population-Based Cohort Study on Treatment and Overall Survival of Patients Clinically Diagnosed With T1 Ampullary Cancer

Author

de Wilde, Anouk J., de Jong, Evelien J.M., Bruno, Marco J., Besselink, Marc G., van der Geest, Lydia G.M., Geurts, Sandra M.E., Groot Koerkamp, Bas, de Hingh, Ignace H.J.T., de Meijer, Vincent E., Miclea, Razvan L., Poley, Jan-Werner, Samarska, Iryna V., van Santvoort, Hjalmar C., Stommel, Martijn W.J., Voermans, Rogier P., Olde Damink, Steven W.M., de Vos-Geelen, Judith, and Bouwense, Stefan A.W.

Published
2024
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24. A tree-based approach to identify indispensable foods in minimum-cost food baskets

Author

Melissa F. Koenen, Romée Geelen, Marleen Balvert, and Hein Fleuren

Subjects
food and nutrition security, cost resilience, diet optimization, food baskets, linear programming, Nutrition. Foods and food supply, TX341-641
Abstract

IntroductionOptimization techniques, such as linear programming, can be used to estimate the minimum cost of a nutrient-adequate food basket, to determine if individuals or households can afford nutritious diets. These cost estimates typically account for seasonal fluctuations but often overlook significant disruptions in the availability of affordable nutritious food that can severely impact food and nutrition security.MethodsThis paper proposes a tree-based method, the binary search tree, to assess the resilience of the cost estimate of the minimum-cost food basket. In particular, this method aims to identify indispensable foods in these baskets — those whose unavailability would lead to a substantial cost increase. The binary search tree operates by iteratively excluding essential food items while ensuring the construction of minimum-cost nutritious baskets. It considers all relevant combinations of foods up to a specified size and avoids unnecessary optimizations, thereby saving computation time. We describe how the resulting tree can be evaluated and condensed to capture only the necessary information for decision makers. The construction and evaluation of the binary search tree are independent of the (dietary) restrictions or type of optimization model (i.e., linear, non-linear or integer) included.ResultsIn general, the binary search tree can identify all (combinations of) foods whose exclusion leads to a significant cost increase of a nutritious food basket. Furthermore, it can detect possible substitute effects between foods and identify key limiting nutrients. A case study is presented in which the binary search tree is applied to data from Ebonyi, Nigeria, modeled using linear programming. We report all combinations of up to five foods that, when unavailable, can impact food and nutrition security in Ebonyi.ConclusionThe BST can provide insights into local food and nutrition security when facing drastic disruptions in access to nutritious foods by identifying indispensable foods. Its results can be used to inform and design interventions in the context of humanitarian operations.

Published
2024
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25. Aplospojaveedins A–C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy

Author

Ying Gao, Marian Frank, Nicole Teusch, Dennis Woschko, Christoph Janiak, Attila Mándi, Tibor Kurtán, Rudolf Hartmann, Katja Schiedlauske, Lasse van Geelen, Rainer Kalscheuer, Jesko Kaiser, Christoph G. W. Gertzen, Holger Gohlke, Bin-Gui Wang, Peter Proksch, and Zhen Liu

Subjects
Aplosporella javeedii, alkaloids, OSMAC approach, X-ray diffraction, DFT-NMR calculations, TDDFT-ECD calculations, Microbiology, QR1-502
Abstract

Three sulfur-containing alkaloids aplospojaveedins A–C (1–3) with a hitherto undescribed carbon skeleton comprising octahy-dronaphthalene, α, β-unsaturated lactam and glycine-cysteine moieties were isolated from Aplosporella javeedii. Their structures were elucidated by 1D and 2D NMR spectroscopy, HR-MS, X-ray diffraction analysis, DFT-NMR and TDDFT-ECD calculations. A plausible biosynthetic pathway and putative targets are described. The blind docking suggested that 1–3 may have functional effects on several putative targets such as the GPCR cannabinoid receptor 2 or the integrin α5β1 complex.

Published
2024
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26. Perspectives of the medical oncologist regarding adjuvant chemotherapy for pancreatic cancer: An international expert survey and case vignette study

Author

Bockorny, B., Carrato, A., Chen, L., Coveler, A.L., Dajani, O., Diaz, L.A., El-Rayes, B.F., Goldstein, D., Halfdanarson, T.R., Hosein, P.J., Kim, E.J., Liang, T., Melisi, D., Pruijt, J.F.M., Santoro, A., Verschoor, A.J., van Voorthuizen, T., Biesma, N.C., Graus, M.U.J.E., Cirkel, G.A., Besselink, M.G., de Groot, J.W.B., Koerkamp, B. Groot, Herbschleb, K.H., Los, M., Verdonk, R.C., Wilmink, J.W., Cervantes, A., Valle, J.W., Valkenburg-van Iersel, L.B.J., Froeling, F.E.M., Molenaar, I.Q., Daamen, L.A., de Vos-Geelen, J., and van Santvoort, H.C.

Published
2025
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29. Safety, efficacy, and reliability evaluation ofa novel small-diameter defibrillation lead: Global LEADR pivotal trial results

Author

Sanders, Prashanthan, Pathak, Rajeev, Denman, Russell Allen, Mihalcz, Attila, Philippon, Francois, Tsang, Bernice, Sumner, Glenn, Chen, Minglong, Han, Xiuebin, Liu, Xingbin, Philbert, Berit Thornvig, Defaye, Pascal, Anselme, Frederic, Stellbrink, Christoph, Chan, Ngai-Yin, Tse, Hung-Fat, De Filippo, Paolo, Ando, Kenji, Kusano, Kengo, Shoda, Morio, Khelae, Surinder Kaur, Lopes do Carmo, Pedro Miguel, Milasinovic, Goran, Boey, Elaine, Anguera Camos, Ignasi, Cano Pérez, Oscar, Whinnett, Zachary, Baranowski, Bryan, Friedman, Meir, Dinerman, Jay, Schaller, Robert, Bozorgnia, Babak, Zakaib, John, Chinitz, Jason, West, Michael, Ramza, Brian, Canby, Robert, Takata, Theodore, Shah, Maully, Winner, Marshall, Wilson, David, Mason, Pamela, Richardson, Travis, Kalahasty, Gautham, Sholevar, Darius, Smith, Timothy, Crossley, George H., III, Hansky, Bert, Shah, Maully J., Richardson, Travis D., Philippon, François, Zakaib, John S., Sholevar, Darius P., Pathak, Rajeev K., Milašinović, Goran, Chinitz, Jason S., West, Michael B., Ramza, Brian M., Han, Xuebin, Carta, Roberto, Geelen, Tessa, Himes, Adam K., Platner, Megan L., Thompson, Amy E., and Mason, Pamela K.

Published
2024
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30. Development of a value-based healthcare burns core set for adult burn care

Author

Spronk, I., van Uden, D., Lansdorp, C.A., van Dammen, L., van Gemert, R., Visser, I., Versluis, G., Wanders, H., Geelen, S.J.G., Verwilligen, R.A.F., van der Vlegel, M., Bijker, G.C., Heijblom, M.C., Fokke-Akkerman, M., Stoop, M., van Baar, M.E., Nieuwenhuis, M.K., Pijpe, A., van Schie, C.M.H., Gardien, K.L.M., Lucas, Y., Snoeks, A., Scholten-Jaegers, S.M.H.J., Meij-de Vries, A., Haanstra, T.M., Weel-Koenders, A.E.A.M., Wood, F.M., Edgar, D.W., Bosma, E., Middelkoop, E., van der Vlies, C.H., and van Zuijlen, P.P.M.

Published
2024
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31. Exploring the potential of human urine derivatives in circular agriculture: a case study on lettuce

Author

Rosalinda Nicastro, Christophe El-Nakhel, Danny Geelen, Giovanna Marta Fusco, Stefania De Pascale, Youssef Rouphael, and Petronia Carillo

Subjects
recycling, wastewater, proline, catalase, MDA, H2O2, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

Unlocking the potential of sustainable agriculture relies on innovative approaches such as recycling crop waste and exploiting wastewater. Herewith, human urine derivatives were integrated into the fertigation of soilless-grown lettuce. The effects were remarkable: not only did they impact primary metabolites such as amino acids, proteins, and sugars, but they also influenced secondary metabolites such as polyphenols and anthocyanins, along with antioxidant enzyme activity. K-struvite, a urine precipitate with CaO and NaOH, elicited responses comparable to those of the control NPK and correlated with high biometric values. Interestingly, urine precipitate–CaO and electrodialysis (ED) concentrate stimulated accumulation of leaf polyphenols and anthocyanins, while urine precipitate–CaO induced high ABTS antioxidant capacity, highlighting their potential to enhance antioxidant activity and nutritive quality. Moreover, hydrolyzed urine and aurin induced a significant boost of essential amino acid content, underlining their role in increasing the nutritive value of lettuce. However, they also correlated with higher levels of MDA, a marker of lipid peroxidation, and reduced APX activity, indicating the need for further optimization. These findings underscore the promising role of human urine as an organic component in soilless lettuce fertilization, paving the way for more sustainable and resource-efficient agricultural practices.

Published
2024
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34. Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol

Author

Harvey, Lisa A., Glinsky, Joanne V., Chu, Jackie, Herbert, Robert D., Liu, Hueiming, Jan, Stephen, Billot, Laurent, Scivoletto, Giorgio, Spooren, Annemie I., Seelen, Henk A., Ben, Marsha, Tranter, Keira, Chen, Lydia W., Rainey, Donna, Rimmer, Christine, Jorgensen, Vivien, Di Natal, Fernanda, Denis, Sophie, Gollan, Emilie J., Tamburella, Federica, Agostinello, Jacqui, van Laake-Geelen, Charlotte M., Bell, Chris, Lincoln, Claire, Stolwijk, Janneke M., van der Lede, Jessica, Paddison, Sue, Oostra, Kristine, Cameron, Ian D., Weber, Gerard, Sherrington, Catherine, Nunn, Andrew K., Synnott, Emma-Leigh, McCaughey, Euan, Kaur, Jasbeer, and Shetty, Sachin

Published
2023
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35. Preoperative chemoradiotherapy but not chemotherapy is associated with reduced risk of postoperative pancreatic fistula after pancreatoduodenectomy for pancreatic ductal adenocarcinoma: a nationwide analysis

Author

Wismans, Leonoor V., Suurmeijer, J. Annelie, van Dongen, Jelle C., Bonsing, Bert A., Van Santvoort, Hjalmar C., Wilmink, Johanna W., van Tienhoven, Geertjan, de Hingh, Ignace H., Lips, Daan J., van der Harst, Erwin, de Meijer, Vincent E., Patijn, Gijs A., Bosscha, Koop, Stommel, Martijn W., Festen, Sebastiaan, den Dulk, Marcel, Nuyttens, Joost J., Intven, Martijn P.W., de Vos-Geelen, Judith, Molenaar, I. Quintus, Busch, Olivier R., Koerkamp, Bas Groot, Besselink, Marc G., and van Eijck, Casper H.J.

Published
2024
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39. Switching from imatinib to nilotinib plus pegylated interferon-α2b in chronic phase CML failing to achieve deep molecular response: clinical and immunological effects

Author

Geelen, Inge G.P., Gullaksen, Stein-Erik, Ilander, Mette M., Olssen-Strömberg, Ulla, Mustjoki, Satu, Richter, Johan, Blijlevens, Nicole M.A., Smit, Willem M., Gjertsen, Bjorn T., Gedde-Dahl, Tobias, Markevärn, Berit, Koppes, Malika M.A., Westerweel, Peter E., Hjorth-Hansen, Henrik, and Janssen, Jeroen J.W.M.

Published
2023
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40. Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3): study protocol for a multicenter randomized controlled trial

Author

van Dam, J. L., Verkolf, E. M. M., Dekker, E. N., Bonsing, B. A., Bratlie, S. O., Brosens, L. A. A., Busch, O. R., van Driel, L. M. J. W., van Eijck, C. H. J., Feshtali, S., Ghorbani, P., de Groot, D. J. A., de Groot, J. W. B., Haberkorn, B. C. M., de Hingh, I. H., van der Holt, B., Karsten, T. M., van der Kolk, M. B., Labori, K. J., Liem, M. S. L., Loosveld, O. J. L., Molenaar, I. Q., Polée, M. B., van Santvoort, H. C., de Vos – Geelen, J., Wumkes, M. L., van Tienhoven, G., Homs, M. Y. V., Besselink, M. G., Wilmink, J. W., and Groot Koerkamp, B.

Published
2023
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42. Oncological resection and perioperative outcomes of robotic, laparoscopic and open pancreatoduodenectomy for ampullary adenocarcinoma: a propensity score matched international multicenter cohort study

Author

Webber, Laurence, Wellner, Ulrich, Ramaekers, Mark, Sparrelid, Ernesto, Malleo, Giuseppe, Ramirez-Del Val, Alejandro, Lancelotti, Francesco, Nappo, Gennaro, Halle-Smith, James, Kent, Tara S., de Vos-Geelen, Judith, de Wilde, Anouk, Lemmers, Daniël H., Bhogal, Ricky, Johansen, Karin, Giani, Alessandro, Giannone, Fabio, Ecker, Brett, Uijterwijk, Bas A., Moekotte, Alma, Boggi, Ugo, Mazzola, Michele, Groot Koerkamp, Bas, Dalle Valle, Raffaele, Koek, Sharnice, Bolm, Louisa, Mazzotta, Alessandro, Luyer, Misha, Goh, Brian K.P., Suarez Muñoz, Miguel A., Björnsson, Bergthor, Kazemier, Geert, Ielpo, Benedetto, Pessaux, Patrick, Kleeff, Jorg, Ghorbani, Poya, Mavroeidis, Vasileios K., Fusai, Giuseppe K., Salvia, Roberto, Zerbi, Alessandro, Roberts, Keith J., Alseidi, Adnan, Al-Sarireh, Bilal, Serradilla-Martín, Mario, Vladimirov, Miljana, Korkolis, Dimitris, Soonawalla, Zahir, Gruppo, Mario, Bouwense, Stefan A.W., Vollmer, Charles M., Behrman, Stephen W., Christein, John D., Besselink, Marc G., and Abu Hilal, Mohammed

Published
2024
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47. Bacterially enhanced plant‐growing media for controlled environment agriculture

Author

Thijs Van Gerrewey, Oscar Navarrete, Maarten Vandecruys, Maaike Perneel, Nico Boon, and Danny Geelen

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract Microbe–plant interactions in the root zone not only shape crop performance in soil but also in hydroponic cultivation systems. The biological and physicochemical properties of the plant‐growing medium determine the root‐associated microbial community and influence bacterial inoculation effectiveness, which affects plant growth. This study investigated the combined impact of plant‐growing media composition and bacterial community inoculation on the root‐associated bacterial community of hydroponically grown lettuce (Lactuca sativa L.). Ten plant‐growing media were composed of varying raw materials, including black peat, white peat, coir pith, wood fibre, composted bark, green waste compost, perlite and sand. In addition, five different bacterial community inocula (BCI S1–5) were collected from the roots of lettuce obtained at different farms. After inoculation and cultivation inside a vertical farm, lettuce root‐associated bacterial community structures, diversity and compositions were determined by evaluating 16S rRNA gene sequences. The study revealed distinct bacterial community structures among experimental replicates, highlighting the influence of raw material variations on root‐associated bacterial communities, even at the batch level. However, bacterial community inoculation allowed modulation of the root‐associated bacterial communities independently from the plant‐growing medium composition. Bacterial diversity was identified as a key determinant of plant growth performance with green waste compost introducing Bacilli and Actinobacteria, and bacterial community inoculum S3 introducing Pseudomonas, which positively correlated with plant growth. These findings challenge the prevailing notion of hydroponic cultivation systems as sterile environments and highlight the significance of proper plant‐growing media raw material selection and bacterial community inoculation in shaping root‐associated microbiomes that provide stability through microbial diversity. This study supports the concept of creating bacterially enhanced plant‐growing media to promote plant growth in controlled environment agriculture.

Published
2024
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48. Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial

Author

Thompson, Alexander, Danta, Mark, Poursoltan, Pirooz, Kiberu, Andrew, Chittajallu, Renuka, Sood, Siddarth, Stauber, Rudolf, Pinter, Matthias, Peck-Radosavljevic, Markus, Decaestecker, Jochen, Cuyle, Pieter-Jan, Verset, Gontran, Van Vlierberghe, Hans, De Azevedo, Sergio, Andrade, Livia, Cunha Júnior, Ademar, Faria, Luiza, Yen, Cheng Tzu, Colli, Leandro, Asselah, Jamil, Kavan, Petr, Marquez, Vladimir, Brahmania, Mayur, Li, Qiang, Xing, Baocai, Guo, Yabing, Chen, Zhendong, Zhao, Haitao, Peng, Tao, Wang, Liming, Wang, Lu, Liu, Hongming, Wu, Feixiang, Qin, Lunxiu, Zheng, Qichang, Ying, Jieer, Li, Haitao, Wen, Tianfu, Qin, Shukui, Wen, Xiaoyu, Liu, Yunpeng, Chen, Minshan, Wang, Boqing, Bai, Yuxian, He, Yifu, Zhao, Hong, Zhou, Dong, Dai, Chaoliu, Teng, Gaojun, Cui, Shuzhong, Gao, Yi, Zhang, Xizhi, Lu, Zheng, Yin, Tao, Ding, Youming, Jia, Weidong, Xia, Yongxiang, Sun, Beicheng, Xia, Qiang, Yuan, Yufeng, Sun, Huichuan, Shi, Xuetao, Guzmán, Adrián, Corrales, Luis, Kral, Zdenek, Priester, Peter, Kubala, Eugen, Blanc, Jean Frederic, Bourliere, Marc, Peron, Jean Marie, Borg, Christophe, Bronowicki, Jean-Pierre, Ganne, Nathalie, Decaens, Thomas, Uguen, Thomas, Heurgue, Alexandra, Trojan, Joerg, Gonzalez-Carmona, Maria Angeles, Roderburg, Christoph, Ettrich, Thomas, Schotten, Clemens, Kandulski, Arne, Yau, Thomas, Chan, Lam, Scartozzi, Mario, Masi, Gianluca, Fanello, Silvia, Battezzati, Pier Maria, Leonardi, Francesco, Ghidini, Michele, Numata, Kazushi, Morimoto, Manabu, Hidaka, Hisashi, Tsuchiya, Kaoru, Yamashita, Tatsuya, Kato, Naoya, Kudo, Masatoshi, Hagihara, Atsushi, Koga, Hironori, Arakawa, Tomohiro, Nakamura, Ikuo, Kawamura, Yusuke, Kawaoka, Tomokazu, Shimada, Mitsuo, Hasegawa, Kiyoshi, Marusawa, Hiroyuki, Nakamura, Shinchiro, Hiraoka, Atsushi, Hayashi, Hiromitsu, Takeda, Shin, Lee, Han Chu, Paik, Seung Woon, Kim, Do Young, Lee, Jung Il, Jeong, Sook-Hyang, Kim, Won, Tak, Won Young, Heo, Jeong, Kim, Hyeyeong, Chon, Hong Jae, Cheong, Jaeyoun, Yoon, Seung Kew, Yoon, Jung-Hwan, Villalobos, Ricardo, Martinez Rodriguez, Jorge Luis, Oyervides Juarez, Victor, Hernández, Carlos Alberto, Klumpen, Heinz-Josef, de Vos-Geelen, Judith, Gane, Edward, Montenegro, Paola, Torres Mattos, Cesar, Janczewska, Ewa, Kawecki, Maciej, Nowakowska-Zajdel, Ewa, Fedenko, Alexander, Granov, Dmitrii, Alyasova, Anna, Sekacheva, Marina, Ledin, Evgeny, Samol, Jens, Toh, Han Chong, Calvo Campos, Mariona, Gomez Martin, Carlos, Lopez Lopez, Carlos, Muñoz Martin, Andres Jesus, Calleja Panero, Jose Luis, Montero Alvarez, Jose Luis, Reig Monzón, Maria, Delgado Mingorance, Ignacio, Minguez Rosique, Beatriz, Cheng, Ann Lii, Huang, Yi-Hsiang, Lin, Shi-Ming, Huang, Jee-Fu, Yu, Ming-Lung, Su, Wei-Wen, Korphaisarn, Krittiya, Maneenil, Kunlatida, Samdaengpan, Chayanee, Tharavichitkul, Ekkapong, Ozguroglu, Mustafa, Kose, Fatih, Harputluoglu, Hakan, Buchschacher, Gary, Thuluvath, Paul, Xiong, Henry, Patel, Mital, Gold, Philip, Li, Daneng, Brooks, Gabriel, Masood, Ashiq, Patel, Reema, George, Ben, Salgia, Reena, Manji, Gulam, Crow, Mary, Kaseb, Ahmed, Dugan, Matthew, Kadakia, Kunal, Kardosh, Adel, Gibbs, John, Shah, Ashesh, Burris III, Howard, Hsiehchen, David, Cheng, Ann-Lii, Kaseb, Ahmed O, Yopp, Adam C, Zhou, Jian, Nakamura, Shinichiro, Cha, Edward, Hack, Stephen P, Lian, Qinshu, Ma, Ning, Spahn, Jessica H, Wang, Yulei, Wu, Chun, and Chow, Pierce K H

Published
2023
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50. Population-based impact of COVID-19 on incidence, treatment, and survival of patients with pancreatic cancer

Author

Siesling, S., van Hoeve, J.C., Merkx, M.A.W., de Wit, N.J., Helsper, C.W., Dingemans, I., Nagtegaal, I.D., van der Schaaf, M., van Gils, C.H., van Weert, H.C.P.M., Verheij, M., Graus, Merlijn U.J.E., de Hingh, Ignace H.J.T., Besselink, Marc G., Bruno, Marco J., Wilmink, Johanna W., de Meijer, Vincent E., van Velthuysen, Marie-Louise F., Valkenburg-van Iersel, Liselot B.J., van der Geest, Lydia G.M., and de Vos-Geelen, Judith

Published
2023
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