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Your search keyword '"Gasparotto Júnior, Arquimedes"' showing total 19 results
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19 results on '"Gasparotto Júnior, Arquimedes"'

2. Pharmacological mechanisms involved in the diuretic activity of the ethanol-soluble fraction of Baccharis milleflora (Less.) DC. - An ethnopharmacological investigation

Author

Klider, Lislaine Maria, Marques, Aline Aparecida Macedo, Moreno, Karyne Garcia Tafarelo, da Silva, Gabriela Pereira, Mizuno, Gabriela Albertinazi, Farias, Katyuce de Souza, Monteiro, Luciane Mendes, de Almeida, Valter Paes, Monchak, Irailson Thierry, da Silva, Denise Brentan, Manfron, Jane, and Gasparotto Junior, Arquimedes

Published
2024
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5. Small conductance calcium-activated potassium channels and nitric oxide/cGMP pathway mediate cardioprotective effects of Croton urucurana Baill. In hypertensive rats

Author

Lopes, Katiana Simões, Marques, Aline Aparecida Macedo, Moreno, Karyne Garcia Tafarelo, Lorençone, Bethânia Rosa, Leite, Patrícia Regina Terço, da Silva, Gabriela Pereira, dos Santos, Ariany Carvalho, Souza, Roosevelt Isaías Carvalho, Gasparotto, Francielly Mourão, Cassemiro, Nadla Soares, Lourenço, Emerson Luiz Botelho, Klider, Lislaine Maria, Manfron, Jane, Silva, Denise Brentan, and Gasparotto Junior, Arquimedes

Published
2022
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6. Cardioprotective effects of Talinum paniculatum (Jacq.) Gaertn. in doxorubicin-induced cardiotoxicity in hypertensive rats

Author

Souto, Carla Geórgia Rodrigues Guimarães, Lorençone, Bethânia Rosa, Marques, Aline Aparecida Macedo, Palozi, Rhanany Alan Calloi, Romão, Paulo Vitor Moreira, Guarnier, Lucas Pires, Tirloni, Cleide Adriane Signor, dos Santos, Ariany Carvalho, Souza, Roosevelt Isaías Carvalho, Zago, Priscila Megda João Job, Lívero, Francislaine Aparecida dos Reis, Lourenço, Emerson Luiz Botelho, Silva, Denise Brentan, and Gasparotto Junior, Arquimedes

Published
2021
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8. Ethnopharmacological investigation of the cardiovascular effects of the ethanol-soluble fraction of Aloysia polystachya (Griseb.) Moldenke leaves in spontaneously hypertensive rats

Author

Marques, Aline Aparecida Macedo, Lorençone, Bethânia Rosa, Romão, Paulo Vitor Moreira, Guarnier, Lucas Pires, Palozi, Rhanany Alan Calloi, Moreno, Karyne Garcia Tafarelo, Tirloni, Cleide Adriane Signor, dos Santos, Ariany Carvalho, Souza, Roosevelt Isaías Carvalho, Klider, Lislaine Maria, Lourenço, Emerson Luiz Botelho, Tolouei, Sara Emilia Lima, Budel, Jane Manfron, Khan, Shabana I., Silva, Denise Brentan, and Gasparotto Junior, Arquimedes

Published
2021
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9. Nephroprotective and antilithiatic activities of Costus spicatus (Jacq.) Sw.: Ethnopharmacological investigation of a species from the Dourados region, Mato Grosso do Sul State, Brazil

Author

Moreno, Karyne Garcia Tafarelo, Gasparotto Junior, Arquimedes, dos Santos, Ariany Carvalho, Palozi, Rhanany Alan Calloi, Guarnier, Lucas Pires, Marques, Aline Aparecida Macedo, Romão, Paulo Vitor Moreira, Lorençone, Bethânia Rosa, Cassemiro, Nadla Soares, Silva, Denise Brentan, Tirloni, Cleide Adriane Signor, and de Barros, Márcio Eduardo

Published
2021
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10. From general toxicology to DNA disruption: A safety assessment of Plinia cauliflora (Mart.) Kausel

Author

Palozi, Rhanany Alan Calloi, Lorençone, Bethânia Rosa, Guarnier, Lucas Pires, Romão, Paulo Vitor Moreira, Marques, Aline Aparecida Macedo, Hulsmeyer, Ana Paula Cestari Rodrigues, Lourenço, Emerson Luiz Botelho, Tolouei, Sara Emilia Lima, da Silva, Gabriela Neubert, Curi, Tatiana Zauer, Passoni, Marcella Tapias, Dalsenter, Paulo Roberto, de Araújo, Flávio Henrique Souza, Oesterreich, Silvia Aparecida, Souza, Roosevelt Isaias Carvalho, dos Santos, Ariany Carvalho, de Castilho, Pamella Fukuda, de Oliveira, Kelly Mari Pires, Nocchi, Samara Requena, Silva, Denise Brentan, and Gasparotto Junior, Arquimedes

Published
2020
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11. Promising therapeutic use of Baccharis trimera (less.) DC. as a natural hepatoprotective agent against hepatic lesions that are caused by multiple risk factors

Author

Barbosa, Rodrigo Jachimowski, Ratti da Silva, Gustavo, Cola, Itaruã Machri, Kuchler, Joice Cristina, Coelho, Natalia, Barboza, Lorena Neris, Menetrier, Jacqueline Vergutz, de Souza, Ronaldo, Zonta, Franciele Nascimento, Froehlich, Diego Lacir, Jacomassi, Ezilda, Soares, Andréia Assunção, Velasques, Leonardo Garcia, Veiga, Alan de Almeida, Souza, Lauro Mera de, Lovato, Evellyn Claudia Wietzkoski, Ribeiro-Paes, João Tadeu, Gasparotto Junior, Arquimedes, Acco, Alexandra, and Lívero, Francislaine Aparecida dos Reis

Published
2020
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14. Short-term carcinogenesis evaluation of Casearia sylvestris

Author

Tirloni, Cleide A.S., Traesel, Giseli K., Lívero, Francislaine A.R., Neto, Salvador D.V., de Faria Junior, Ronaldo, Paim, Thaís C., Santos, Joyce A., Oesterreich, Silvia A., Santos, Ariany C., Souza, Roosevelt I.C., Cardozo Junior, Euclides L., and Gasparotto Junior, Arquimedes

Published
2017
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19. Hypotensive and diuretic effect of the butanolic soluble fraction of the hydroethanolic extract of bark of Scutia buxifolia Reissek in rats.

Author

Da Silva, Rita de C.V.de A.F., de Souza, Priscila, Crestani, Sandra, Gasparotto Júnior, Arquimedes, Boligon, Aline A., Athayde, Margareth L., and da Silva-Santos, José Eduardo

Subjects
*HYPERTENSION, *CARDIOVASCULAR disease prevention, *MEDICINAL plants, *ALTERNATIVE medicine, *ANIMAL experimentation, *ARTERIES, *BARK, *BIOPHYSICS, *BLOOD pressure, *BLOOD pressure measurement, *DIURESIS, *DIURETICS, *ANTIHYPERTENSIVE agents, *RESEARCH methodology, *NITRIC oxide, *ORAL drug administration, *RATS, *URINATION, *PLANT extracts, *DESCRIPTIVE statistics
Abstract

Ethnopharmacological relevance Scutia buxifolia , a native tree popularly known as “coronilha”, is widely used in Brazilian folk medicine for diuretic and anti-hypertensive purposes. Aim of the study We investigated the effects of a butanolic (BuOH) soluble fraction of the hydroethanolic extract (HESB) of bark of Scutia buxifolia on both blood pressure and urinary excretion of rats. The involvement of the nitric oxide/guanylate cyclase pathway in the hypotensive effect found was also explored. Material and methods We tested the effect of the BuOH soluble fraction of HESB on the mean arterial pressure (MAP) of anesthetized rats. The fraction was administered at doses of 1, 3 and 10 mg/kg (i.v.) in normotensive rats during continuous infusion of vehicle (10 μl/min), or phenylephrine (4 μg/kg/min), or l -NAME (7 mg/kg/min), two approaches able to induce a sustained hypertensive state. In some experiments, a bolus injection of ODQ (2 mg/kg) was administered in animals infused with phenylephrine before the administration of the BuOH soluble fraction of HESB. We also measured the effects of the BuOH soluble fraction on the MAP of spontaneously hypertensive rats (SHR). Separate groups of rats were treated orally with either HESB (10, 30 or 100 mg/kg), or its BuOH soluble fraction (3, 10 or 30 mg/kg), and were subjected to measurement of diuresis and blood pressure. Results The BuOH soluble fraction of HESB (10 mg/kg, i.v.) reduced the MAP of both phenylephrine-infused and SHR rats by 20.6±6.0 and 41.8±8.3 mm Hg, respectively. However, no hypotensive effect was found in normotensive animals infused with l -NAME, a non-selective inhibitor of nitric oxide synthase, or animals previously treated with the soluble guanylate cyclase inhibitor ODQ. The urinary excretion was increased by 70% at 6–8 h after a single oral administration of the BuOH soluble fraction of HESB (10 mg/kg), without change in urinary density, pH, or Na + and K + concentrations. In addition, MAP was lower 3 h after the acute oral treatment with the BuOH soluble fraction (82.1±3.8 mm Hg), compared with MAP of animals from the control group (97±3.2 mm Hg). Conclusion This study demonstrates that the BuOH soluble fraction of the hydroethanolic bark of Scutia buxifolia , which has its bark used in folk medicine for the treatment of hypertension mainly by its presumed diuretic properties, possesses both diuretic and hypotensive effects in rats, and that at least the hypotensive effect is fully dependent on activation of the nitric oxide/guanylate cyclase pathway. [ABSTRACT FROM AUTHOR]

Published
2015
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