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1. Human Immunodeficiency Virus Type 1 Group O Infection in France: Clinical Features and Immunovirological Response to Antiretrovirals

Author

Henri Panjo, Guillemette Unal, François Simon, Jean-Christophe Plantier, Elodie Alessandri-Gradt, Diane Descamps, Charlotte Charpentier, Juliette Pavie, Marie Leoz, Francis Barin, Laurence Meyer, Clément Lefèvre, Orivao Study, Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Morphogénèse et antigénicité du VIH et du virus des Hépatites (MAVIVH - U1259 Inserm - CHRU Tours ), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Faculté de Médecine [Université Paris Diderot - Paris 7], Université Paris Diderot - Paris 7 (UPD7), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), ORIVAO Study : Chennebault J, Fialaire P, Le Guillou-Guillemette H, Rehaiem S, Chanzy B, Clavere G, Gaillat J, Courdavault L, Genet P, Gerbe J, Benoit C, Honore Bouakline S, Waldner A, Bettinger D, Chirouze C, Bernard N, Reigadas S, Dupont X, Gaillard JL, Gault E, Reimann E, Otterbein G, Thomas L, Vaghefi P, Benoit M, Buthiot N, Goux A, Chambrin V, Deback C, Fior R, Raho Moussa M, Antoniotti O, Coban D, Cormerais L, Henquell C, Jacomet C, Lesens O, Chanoine N, Villmant A, Van Autreve JL, Bloch M, Ichou H, Manceron V, Mortier E, Zeng A, Bouvier-Alias M, Dominguez S, Lascaux-Cametez AS, Lelievre JD, Levy Y, Melica-Gregoire G, Pawlotsky JM, Pothier P, Waldner A, Inchiappa L, Verhaeghe A, Olivier B, Pathe JP, Berthe H, Mathez D, Favret V, Troisvallets D, Vandemeulebroucke E, Ceccaldi J, El Harif Z, Bocket L, Barbut P, Chaix F, Lambert C, Lambolez T, Miatezila J, Son O, Brunet P, Chappe C, Dhiver C, Lecomte V, Meddeb L, Poizot-Martin I, Tamalet C, Valadier J, Beck-Wirth G, Benomar M, Delarbre JM, Peter JM, Bevilacqua S, Venard V, Daneluzzi V, Idri N, Montoya B, Ferre V, Garnier E, Hue H, Larmet L, Point P, Raffi F, Reliqiet V, Rodallec A, Secher S, Amoyel P, Botton E, Janowski M, Le Cocguic Y, Deleplanque P, Descamps JM, Lapine M, Sunder S, Chansombat M, Charpentier C, Damond F, Diallo B, Duval X, Julia Z, Landman R, Legac S, Rioux C, Yeni P, Krivine A, Blanche P, Cros A, Gazalet P, Ghosn J, Krivine A, Sobel A, Bercot B, Diemer M, Parrinello M, Bey Boumezrag C, Bodard L, Gibert S, Huche FX, Raffenne L, Strebler M, Blanc C, Bourzam E, Hansel B, Lupin C, Wirden M, Bourzam E, Collias L, Effa J, Jung C, Pavie J, Pere H, Si Mohamed A, Delaugerre C, Gerard L, Loze B, Maylin S, Nabias R, Ponscarme D, Deleuze J, Rozenberg F, Bachour B, Bani-Sadr F, Chas J, Hamidi M, Kherallah L, Le Nagat S, Le Pendeven C, Moreau F, Nicolas JC, Schneider V, Tabone MD, Vaudre G, Giraudeau G, Le Moal G, Plainchamp D, Blondin G, Dorval I, Duthe JC, Perfezou P, Berger JL, Brodard V, Kmiec I, Rouger C, Strady C, Chappelin JM, Maillard A, Ratajczak M, Debab Y, De Oliveira F, Depatureaux A, Gueit I, Lemee V, Theron D, Pasdeloup I, Camps P, Bigaillon C, Ficko C, Imbert C, Rapp C, Grand C, Michau C, Bornarel D, Devillier P, Farfour E, Majerholc C, Vignon D, Zucman D, El Addouli M, Danjoux MF, Journe J, Leveneur Y, Marchou B, Nicot F, Prevoteau Du Clary F, Bonne S., Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Dupuis, Christine

Subjects
0301 basic medicine, Microbiology (medical), Cart, Adult, Male, medicine.medical_specialty, Anti-HIV Agents, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Gastroenterology, 03 medical and health sciences, Internal medicine, Medicine, Humans, Protease inhibitor (pharmacology), Survival analysis, Reverse-transcriptase inhibitor, business.industry, Genetic Variation, Middle Aged, Viral Load, 030112 virology, Antiretroviral therapy, 3. Good health, CD4 Lymphocyte Count, Regimen, 030104 developmental biology, Infectious Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, HIV-1, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business, Viral load, medicine.drug
Abstract

International audience; Background:To obtain reliable clinical data of human immunodeficiency virus type 1 group O (HIV-1/O) infection, and immunovirological responses to combination antiretroviral therapy (cART), in a large series of 101 patients.Methods:Piecewise linear models were used to estimate CD4 count before and after cART initiation. Kaplan-Meier survival curves were used to estimate time to reach clinical stage C before antiretroviral therapy (ART) and to analyze time to achieve a plasma viral load (pVL)

Published
2018

2. Comparison of eMAG™ versus NucliSENS ® EasyMAG ® performance on clinical specimens.

Author

Garcia M, Chessa C, Bourgoin A, Giraudeau G, Plouzeau C, Agius G, Lévêque N, and Beby-Defaux A

Subjects
Automation, Laboratory methods, DNA, Viral genetics, Humans, Viruses genetics, DNA, Viral isolation & purification, Molecular Diagnostic Techniques methods, Specimen Handling methods, Viral Load methods, Virus Diseases diagnosis, Viruses isolation & purification
Abstract

Background: eMAG™ (bioMerieux) is a new nucleic acid extraction platform based on magnetic silica technology, like its predecessor, NucliSENS ® easyMAG ® (bioMerieux). Using the same reagents and disposables, eMAG™ adds further automation, allowing simultaneous extraction of 48 samples directly from primary tubes, and distribution of nucleic acid extracts on PCR strips or in tubes at the end of the extraction process., Objective: To compare the performance of eMAG™ and easyMAG ® on various clinical specimens., Study Design: Respiratory (n=199), whole blood (n=50), plasma (n=25) and urine (n=25) specimens were extracted in parallel on both platforms. Both qualitative (respiratory virus, cell control, CMV, EBV, HHV6 and BKV detection) and quantitative (respiratory virus and cell control cycle thresolds, and CMV, EBV, HHV6 and BKV viral loads) results were compared., Results: Detection of qualitative targets showed good agreement, ranging from 84.6% for whole blood to 95.9% for respiratory specimens. Correlations between quantitative results were good, with R 2 ranging from 0.802 to 0.995. Quantitative results showed average overall differences below 0.10 log 10 copies/mL between eMAG™ and easyMAG ® ., Conclusions: The two platforms showed comparable performance on the types of clinical specimen tested. With higher automation and throughput than easyMAG ® , the eMAG™ platform is likely to be advantageous for laboratories performing a large number of molecular analyses., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Published
2017
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3. Reliability of the INSTI® rapid test for the diagnosis of HIV-1 non-B subtypes and recombinant variants.

Author

Goupil de Bouillé J, Le Moal G, Hocqueloux L, Guigon A, Plainchamp D, Giraudeau G, Theillay A, Languille A, Bélec L, and Prazuck T

Subjects
Adult, Female, HIV-1 classification, Humans, Male, Middle Aged, Sensitivity and Specificity, Genotype, HIV Antibodies blood, HIV Infections diagnosis, HIV-1 immunology, HIV-1 isolation & purification, Recombination, Genetic, Serologic Tests methods
Abstract

Data regarding the efficacy of Rapid HIV tests (RHTs) in detecting non-B subtype HIV-1 are limited. We evaluated the sensitivity of the INSTI® test for the detection of HIV-1 antibodies for the diagnosis of HIV-1 non-B subtypes and recombinant variants. We identified adults with HIV-1 infection due to non-B subtypes and recombinant variants. The participants were re-tested with INSTI® test. We included 258 patients. Overall, the INSTI® test sensitivity was 98.4% (95%CI: 96.9-99.9%). For the major CRF_02AG subtype, the sensitivity was 99.0% (95%CI: 97.1-100%). The HIV INSTI® test is reliable for the detection of various non-B HIV-1 antibodies., (© 2015 Wiley Periodicals, Inc.)

Published
2016
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4. Algorithm-based prediction of HIV-1 subtype D coreceptor use.

Author

Dina J, Raymond S, Maillard A, Le Guillou-Guillemette H, Rodalec A, Beby-Defaux A, Giraudeau G, Vallet S, Mourez T, Payan C, Vabret A, Ruffault A, Ferre V, Izopet J, and Plantier JC

Subjects
Genotype, Humans, Molecular Sequence Data, RNA, Viral genetics, Sensitivity and Specificity, Sequence Analysis, DNA, Algorithms, Computational Biology methods, HIV-1 genetics, HIV-1 physiology, Receptors, HIV metabolism, Viral Tropism, Virus Attachment
Abstract

We compared the coreceptor tropism-predicting performance of a specific genotypic algorithm for HIV-1 subtype D and that of the geno2pheno algorithm with different cutoffs. The D-specific algorithm and geno2pheno with a false-positivity rate cutoff of 2.5% had the same concordance with the phenotypic determination. The geno2pheno algorithm with a false-positivity rate cutoff of 2.5%, more sensitive but slightly less specific, seems to be an appropriate alternative.

Published
2013
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5. Autoimmune protein S activity deficiency following a Q fever.

Author

Boinot C, Planchard D, Giraudeau G, Turhan A, Agius G, and Guicheteau M

Subjects
Adult, Autoantibodies blood, Autoimmune Diseases, Humans, Male, Protein S immunology, Protein S Deficiency etiology, Q Fever complications
Published
2007

6. Genital recurrent infection occurring 6 months after meningitis due to the same herpes simplex virus type 2 (HSV-2) strain evidence by restriction endonuclease analysis.

Author

Venot C, Beby A, Bourgoin A, Giraudeau G, Becq-Giraudon B, and Agius G

Subjects
Cerebrospinal Fluid virology, DNA Fingerprinting, DNA Restriction Enzymes metabolism, DNA, Viral analysis, Female, Herpes Genitalis virology, Herpesvirus 2, Human genetics, Humans, Middle Aged, Recurrence, Herpes Genitalis diagnosis, Herpesvirus 2, Human isolation & purification, Meningitis, Viral diagnosis
Abstract

Herpes simplex virus type 2 (HSV-2) is more often sexually transmitted and associated with genital recurrent infection. However, HSV-2 neurological manifestations such as meningitis were already reported. We describe a case of meningitis due to HSV-2, preceded by signs suggesting a common cystitis, in a woman with no history of primary or recurrent genital infection. Six months later genital herpetic lesions occurred. One HSV-2 strain was obtained from cerebrospinal fluid (CSF) and another from genital lesions. The molecular comparative analysis using restriction endonuclease digestion patterns showed the similarity of the two strains. Our report illustrates that HSV-2 infections are underdiagnosed and that molecular techniques can be of value in clarifying the physiopathology of HSV diseases.

Published
1998
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7. Seroprevalences of Toxoplasma, malaria, rubella, cytomegalovirus, HIV and treponemal infections among pregnant women in Cotonou, Republic of Benin.

Author

Rodier MH, Berthonneau J, Bourgoin A, Giraudeau G, Agius G, Burucoa C, Hekpazo A, and Jacquemin JL

Subjects
Adolescent, Adult, Animals, Antibodies, Bacterial blood, Antibodies, Protozoan blood, Antibodies, Viral blood, Cytomegalovirus immunology, Female, Humans, Plasmodium falciparum immunology, Pregnancy, Toxoplasma immunology, Treponema pallidum immunology, Cytomegalovirus Infections epidemiology, HIV Seroprevalence, Malaria, Falciparum epidemiology, Pregnancy Complications, Infectious epidemiology, Rubella epidemiology, Syphilis epidemiology, Toxoplasmosis epidemiology
Abstract

Seroprevalences for toxoplasmosis, malaria, rubella, cytomegalovirus, HIV and treponemal infections were evaluated among 211 pregnant women residing in the Cotonou area, Republic of Benin. One hundred and thirteen women (53.6%) had toxoplasma antibodies, 185 (87.7%) malaria antibodies and 181 (85.8%) rubella antibodies. Among the 205 (97.2%) women with cytomegalovirus antibodies, 6 presented recent or current infection. No HIV seropositivity was detected. Five (2.4%) of these women had a positive treponematosis serology corresponding to previous infection or reinfection. These results were compared with previous studies conducted in Africa. Routine serological screening should be recommended in young age and in pregnancy for rubella, only in pregnant women for HIV and toxoplasma infections, in order to control their possible consequences on women and newborns.

Published
1995
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