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381 results on '"Fullerton, Heather J"'

1. Common Features Between Stroke Following Varicella in Children and Stroke Following Herpes Zoster in Adults : Varicella-Zoster Virus in Trigeminal Ganglion

Author

Grose, Charles, Shaban, Amir, Fullerton, Heather J., Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Casadevall, Arturo, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Malissen, Bernard, Series Editor, Rappuoli, Rino, Series Editor, Arvin, Ann M., editor, Moffat, Jennifer F., editor, Abendroth, Allison, editor, and Oliver, Stefan L, editor

Published
2023
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3. Childhood stroke

Author

Sporns, Peter B., Fullerton, Heather J., Lee, Sarah, Kim, Helen, Lo, Warren D., Mackay, Mark T., and Wildgruber, Moritz

Published
2022
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11. Recent Advances in Childhood Arterial Ischemic Stroke

Author

Fox, Christine K. and Fullerton, Heather J.

Subjects
Medicine & Public Health, Cardiology, Angiology, Childhood stroke, Arterial ischemic stroke, Cerebral arteriopathy, Thrombolysis, Stroke outcomes
Abstract

Although many underlying diseases have been reported in the setting of childhood arterial ischemic stroke, emerging research demonstrates that non-atherosclerotic intracerebral arteriopathies in otherwise healthy children are prevalent. Minor infections may play a role in arteriopathies that have no other apparent underlying cause. Although stroke in childhood differs in many aspects from adult stroke, few systematic studies specific to pediatrics are available to inform stroke management. Treatment trials of pediatric stroke are required to determine the best strategies for acute treatment and secondary stroke prevention. The high cost of pediatric stroke to children, families, and society demands further study of its risk factors, management, and outcomes. This review focuses on the recent findings in childhood arterial ischemic stroke.

Published
2010

12. Brain Arteriovenous Malformation Recurrence After Apparent Microsurgical Cure: Increased Risk in Children Who Present With Arteriovenous Malformation Rupture

Author

Copelan, Alexander, Drocton, Gerald, Caton, M. Travis, Smith, Eric R., Cooke, Daniel L., Nelson, Jeffrey, Abla, Adib A., Fox, Christine, Amans, Matthew R., Dowd, Christopher F., Halbach, Van V., Higashida, Randall T., Lawton, Michael T., Kim, Helen, Fullerton, Heather J., Gupta, Nalin, and Hetts, Steven W.

Published
2020
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24. Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies

Author

Bernard, Timothy J., Beslow, Lauren A., Manco-Johnson, Marilyn J., Armstrong-Wells, Jennifer, Boada, Richard, Weitzenkamp, David, Hollatz, Amanda, Poisson, Sharon, Amlie-Lefond, Catherine, Lo, Warren, deVeber, Gabrielle, Goldenberg, Neil A., Dowling, Michael M., Roach, E. Steve, Fullerton, Heather J., Benseler, Susanne M., Jordan, Lori C., Kirton, Adam, and Ichord, Rebecca N.

Published
2016
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35. Arteriopathy Diagnosis in Childhood Arterial Ischemic Stroke: Results of the Vascular Effects of Infection in Pediatric Stroke Study

Author

Wintermark, Max, Hills, Nancy K., deVeber, Gabrielle A., Barkovich, A. James, Elkind, Mitchell S.V., Sear, Katherine, Zhu, Guangming, Leiva-Salinas, Carlos, Hou, Qinghua, Dowling, Michael M., Bernard, Timothy J., Friedman, Neil R., Ichord, Rebecca N., Fullerton, Heather J., Benedict, S.L., Fox, C.K., Lo, W.D., Tan, M.A., Mackay, M.T., Kirton, A., Hernandez Chavez, M.I., Humphreys, P., Jordan, L.C., Sultan, S.M., Rivkin, M.J., Rafay, M.F., Titomanlio, L., Kovacevic, G.S., Yager, J.Y., Amlie-Lefond, C., Dlamini, N., Condie, J., Yeh, A., Kneen, R., Bjornson, B.H., Pergami, P., Zou, L.P., Elbers, J., Abdalla, A., Chan, A.K., Farooq, O., Lim, M.J., Carpenter, J.L., Pavlakis, S., Wong, V.C., and Forsyth, R.

Published
2014
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38. An Integrated Analysis of Clinical, Genomic, and Imaging Features Reveals Predictors of Neurocognitive Outcomes in a Longitudinal Cohort of Pediatric Cancer Survivors, Enriched with CNS Tumors (Rad ART Pro).

Author

Kline, Cassie, Stoller, Schuyler, Byer, Lennox, Samuel, David, Lupo, Janine M., Morrison, Melanie A., Rauschecker, Andreas M., Nedelec, Pierre, Faig, Walter, Dubal, Dena B., Fullerton, Heather J., and Mueller, Sabine

Subjects
CENTRAL nervous system tumors, CHILDHOOD cancer, CANCER survivors, SINGLE nucleotide polymorphisms, CONVOLUTIONAL neural networks, EXECUTIVE function
Abstract

Background: Neurocognitive deficits in pediatric cancer survivors occur frequently; however, individual outcomes are unpredictable. We investigate clinical, genetic, and imaging predictors of neurocognition in pediatric cancer survivors, with a focus on survivors of central nervous system (CNS) tumors exposed to radiation. Methods: One hundred eighteen patients with benign or malignant cancers (median diagnosis age: 7; 32% embryonal CNS tumors) were selected from an existing multi-institutional cohort (RadART Pro) if they had: 1) neurocognitive evaluation; 2) available DNA; 3) standard imaging. Utilizing RadART Pro, we collected clinical history, genomic sequencing, CNS imaging, and neurocognitive outcomes. We performed single nucleotide polymorphism (SNP) genotyping for candidate genes associated with neurocognition: COMT , BDNF , KIBRA , APOE , KLOTHO. Longitudinal neurocognitive testing were performed using validated computer-based CogState batteries. The imaging cohort was made of patients with available iron-sensitive (n = 28) and/or T2 FLAIR (n = 41) sequences. Cerebral microbleeds (CMB) were identified using a semi-automated algorithm. Volume of T2 FLAIR white matter lesions (WML) was measured using an automated method based on a convolutional neural network. Summary statistics were performed for patient characteristics, neurocognitive assessments, and imaging. Linear mixed effects and hierarchical models assessed patient characteristics and SNP relationship with neurocognition over time. Nested case-control analysis was performed to compare candidate gene carriers to non-carriers. Results: CMB presence at baseline correlated with worse performance in 3 of 7 domains, including executive function. Higher baseline WML volumes correlated with worse performance in executive function and verbal learning. No candidate gene reliably predicted neurocognitive outcomes; however, APOE ϵ4 carriers trended toward worse neurocognitive function over time compared to other candidate genes and carried the highest odds of low neurocognitive performance across all domains (odds ratio 2.85, P =0.002). Hydrocephalus and seizures at diagnosis were the clinical characteristics most frequently associated with worse performance in neurocognitive domains (5 of 7 domains). Overall, executive function and verbal learning were the most frequently negatively impacted neurocognitive domains. Conclusion: Presence of CMB, APOE ϵ4 carrier status, hydrocephalus, and seizures correlate with worse neurocognitive outcomes in pediatric cancer survivors, enriched with CNS tumors exposed to radiation. Ongoing research is underway to verify trends in larger cohorts. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Neuroimaging of Pediatric Intracerebral Hemorrhage

Author

Sporns, Peter B, Psychogios, Marios-Nikos, Fullerton, Heather J, Lee, Sarah, Naggara, Olivier, and Boulouis, Grégoire

Subjects
Pediatric, screening and diagnosis, neuroimaging, Clinical Sciences, lcsh:R, Neurosciences, lcsh:Medicine, intracerebral haemorrhage, Review, Brain Disorders, Stroke, Detection, paediatric stroke, Rare Diseases, Clinical Research, Biomedical Imaging, 4.2 Evaluation of markers and technologies
Abstract

Hemorrhagic strokes account for half of all strokes seen in children, and the etiologies of these hemorrhagic strokes differ greatly from those seen in adult patients. This review gives an overview about incidence and etiologies as well as presentation of children with intracerebral hemorrhage and with differential diagnoses in the emergency department. Most importantly it describes how neuroimaging of children with intracerebral hemorrhage should be tailored to specific situations and clinical contexts and recommends specific imaging protocols for acute and repeat imaging. In this context it is important to keep in mind the high prevalence of underlying vascular lesions and adapt the imaging protocol accordingly, meaning that vascular imaging plays a key role regardless of modality. Magnetic resonance imaging (MRI), including advanced sequences, should be favored whenever possible at the acute phase.

Published
2020

41. Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imaging

Author

Fullerton, Heather J., Wu, Yvonne W., Sidney, Stephen, and Johnston, Claiborne

Subjects
Stroke (Disease) -- Risk factors, Stroke patients -- Health aspects, Children -- Health aspects, Diseases -- Relapse, Diseases -- Risk factors
Abstract

OBJECTIVE. Few data exist regarding rates and predictors of recurrence after childhood arterial ischemic stroke. We sought to establish such rates within a large, multiethnic population and determine whether clinical vascular imaging predicts recurrence. PATIENTS AND METHODS. In a population-based cohort study, we collected data on all documented cases of arterial ischemic stroke among 2.3 million children ( RESULTS. Among 181 incident childhood stroke cases (84 perinatal; 97 later childhood), there were 16 recurrent strokes (1 after a perinatal stroke) at a median of 2.7 months. The 5-year cumulative recurrence rates were 1.2% after perinatal stroke and 19% after later childhood stroke. Of the 97 children with later childhood strokes, 52 received cerebrovascular imaging, predominantly magnetic resonance angiography (n = 36) and conventional angiography (n = 26). Although there were no recurrences among children with normal vascular imaging, children with a vascular abnormality had a 5-year cumulative recurrence rate of 66%. CONCLUSIONS. Strokes recur in one fifth of cases of later childhood arterial ischemic stroke but are rare after perinatal stroke. Among the later childhood cases, cerebrovascular imaging identifies those at highest risk for recurrence., DESPITE INCREASING RECOGNITION of arterial ischemic stroke (AIS) as an important cause of childhood disability, few data exist regarding rates and predictors of recurrent childhood stroke. (1,2) Although children with [...]

Published
2007

42. Maternal and infant characteristics associated with perinatal arterial stroke in the infant

Author

Lee, Janet, Croen, Lisa A., Backstrand, Kendall H., Yoshida, Cathleen K., Henning, Louis H., Lindan, Camilla, Ferriero, Donna M., Fullerton, Heather J., Barkovich, A.J., and Wu, Yvonne W.

Subjects
Infants -- Health aspects, Stroke (Disease) -- Risk factors, Medical research, Medicine, Experimental
Abstract

The study aimed to determine maternal and infant characteristics associated with perinatal arterial ischemic stroke (PAS). It concluded that perinatal arterial ischemic stroke in infants is associated with several independent maternal risk factors.

Published
2005

43. Declining diagnosis of birth asphyxia in California: 1991-2000

Author

Wu, Yvonne W., Backstrand, Kendall H., Zhao, Shoujun, Fullerton, Heather J., and Johnston, S. Claiborne

Subjects
Infants -- Health aspects, Encephalopathy -- Diagnosis, Asphyxia -- Diagnosis
Abstract

Objective. Birth asphyxia is recognized as an important cause of neonatal morbidity and mortality. Whether advances in perinatal care have altered the incidence of birth asphyxia is unknown. We determined the incidence of birth asphyxia diagnoses made over a 10-year period in California. Methods. In a population-based retrospective cohort study of 5 364 663 live births, we determined the incidence and case fatality of birth asphyxia between 1991 and 2000. Using a statewide administrative hospital discharge database, we identified all newborn admissions that generated a diagnosis of birth asphyxia (International Classification of Diseases, Ninth Revision, Clinical Modification codes 768.5, 768.6, or 768.9) or a diagnosis that overlaps with birth asphyxia, such as congenital encephalopathy or fetal distress. We determined incidence and in-hospital case fatality rates adjusted for birth weight and demographic characteristics and stratified by associated perinatal complications. Results. The 24 330 newborns who received a diagnosis of birth asphyxia yielded a population incidence of 4.5 per 1000 live births. Black ethnicity (relative risk [RR]: 1.3; 95% confidence interval [CI]: 1.2-1.3), male gender (RR: 1.2; 95% CI: 1.1-1.2), and low socioeconomic status (RR: 1.2; 95% CI: 1.1-1.2) all were associated with increased risk. The diagnosis of birth asphyxia decreased by 91% from 14.8 to 1.3 per 1000 live births during the study years. This decrease could not be explained by an increased diagnosis of overlapping conditions. Overall case fatality was 4%, and the majority of deaths in infants >2000 g occurred in the presence of congenital anomalies, cord abnormalities, or maternal hemorrhage. In newborns Conclusion. The diagnosis of birth asphyxia has decreased dramatically in recent years. The factors that are responsible for this decline are unclear and deserve additional investigation. Pediatrics 2004;114:1584-1590; asphyxia, epidemiology, neonatal. ABBREVIATIONS. OSHPD, Office of Statewide Health Planning and Development; ICD-9-CM, Classificalion of Diseases, Ninth Revision, Clinical Modification; SES, socioeconomic status; LBW, low birth weight; VLBW, very low birth weight; IUGR, intrauterine growth restriction; RR, reiative risk; CI, confidence interval., The clinical diagnosis of birth asphyxia, along with the closely related conditions of hypoxicischemic encephalopathy and newborn encephalopathy, is recognized as an important cause of morbidity and mortality in newborn [...]

Published
2004

46. Stroke in Children With Posterior Fossa Brain Malformations, Hemangiomas, Arterial Anomalies, Coarctation of the Aorta and Cardiac Defects, and Eye Abnormalities (PHACE) Syndrome: A Systematic Review of the Literature

Author

Siegel, Dawn H., Tefft, Kimberly A., Kelly, Teresa, Johnson, Craig, Metry, Denise, Burrows, Patricia, Pope, Elena, Cordisco, Maria, Holland, Kristen E., Maheshwari, Mohit, Keith, Phillip, Garzon, Maria, Hess, Christopher, Frieden, Ilona J., Fullerton, Heather J., and Drolet, Beth A.

Published
2012
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