116 results on '"Frazier, H."'
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2. Burnout and Turnover Among Program Directors in ACEND-accredited Registered Dietitian Nutritionist Programs: A 2-year Follow-up Study
- Author
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Grace-Fargalia, P. and Frazier, H.
- Published
- 2023
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3. Pandemic Fatigue: Burnout Among Nutrition and Dietetics Program Directors
- Author
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Frazier, H. and Farfaglia, P. Grace
- Published
- 2021
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4. Relationship Between Food Insecurity, Stress, and other Health Markers in College Students During COVID-19
- Author
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Alves Olguin, M., Senne-Duff, B., Frazier, H., and Vallor, A.
- Published
- 2021
- Full Text
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5. Measurement of the cross section for production of bb¯X decaying to muons in pp collisions at √s = 7 TeV
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Chatrchyan, S., Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., Erö, J., Fabjan, C., Friedl, M., Frühwirth, R., Ghete, V. M., Hammer, J., Hoch, M., Hörmann, N., Hrubec, J., Jeitler, M., Kiesenhofer, W., Krammer, M., Liko, D., Mikulec, I., Pernicka, M., Rahbaran, B., Rohringer, C., Rohringer, H., Schöfbeck, R., Strauss, J., Taurok, A., Teischinger, F., Wagner, P., Waltenberger, W., Walzel, G., Widl, E., Wulz, C. E., Mossolov, V., Shumeiko, N., Suarez, Gonzalez, Bansal, J., Benucci, S., Cornelis, L., Wolf, De, E. A., Janssen, Luyckx, X., Maes, S., Mucibello, T., Ochesanu, L., Roland, S., Rougny, B., Selvaggi, R., Van, Haevermaet, Van, Mechelen, Van, Remortel, Van, Spilbeeck, Blekman, A., Blyweert, F., D'Hondt, S., Gonzalez, Suarez, Kalogeropoulos, R., Maes, A., Olbrechts, M., Van, Doninck, Van, Mulders, Van, Onsem, G. P., Villella, Charaf, I., Clerbaux, O., Lentdecker, De, Dero, G., Gay, V., A. P. R., Hammad, G. H., Hreus, Léonard, T., Marage, A., P. E., Thomas, Vander, Velde, Vanlaer, C., Wickens, P., Adler, J., Beernaert, V., Cimmino, K., Costantini, A., Garcia, S., Grunewald, G., Klein, M., Lellouch, B., Marinov, J., Mccartin, A., Ocampo, Rios, A. A., Ryckbosch, Strobbe, D., Thyssen, N., Tytgat, F., Vanelderen, M., Verwilligen, L., Walsh, P., Yazgan, S., Zaganidis, E., Basegmez, N., Bruno, S., Ceard, G., De Favereau De Jeneret, Delaere, J., Pree, Du, Favart, T., Forthomme, D., Giammanco, L., Grégoire, A., Hollar, G., Lemaitre, J., Liao, V., Militaru, J., Nuttens, O., Pagano, C., Pin, D., Piotrzkowski, A., Schul, K., Beliy, N., Caebergs, N., Daubie, T., Alves, E., G. A., Correa Martins, J. r., De Jesus Damiao, Martins, D., Pol, T., E. M., Souza, M. H. G., Aldá, J. r., W. L., Carvalho, Custódio, W., Costa, Da, E. M., De Oliveira Martins, Fonseca De Souza, Matos, Figueiredo, Mundim, D., Nogima, L., Oguri, H., Prado Da Silva, W. L., Santoro, Silva Do Amaral, S. M., Soares, Jorge, Sznajder, L., Anjos, A., T. S., Bernardes, C. A., Dias, F. A., Fernandez Perez Tomei, T. R., Gregores, E. M., Lagana, Marinho, C., Mercadante, F., P. G., Novaes, S. F., Padula, S. S., Genchev, Iaydjiev, V., Piperov, P., Rodozov, S., Stoykova, M., Sultanov, S., Tcholakov, G., Trayanov, V., Vutova, R., Dimitrov, M., Hadjiiska, A., Karadzhinova, R., Kozhuharov, A., Litov, V., Pavlov, L., Petkov, B., Bian, P., J. G., Chen, G. M., Chen, H. S., Jiang, C. H., Liang, Liang, D., Meng, S., Tao, X., Wang, J., Wang, X., Xiao, Z., Xu, H., Zang, M., Zhang, J., Asawatangtrakuldee, Z., Ban, C., Guo, Y., Guo, S., Li, Y., Liu, W., Mao, S., Qian, Y., J. S., Teng, Wang, H., Zhu, S., Zou, B., Cabrera, W., Gomez, Moreno, Osorio, Oliveros, A. F., Sanabria, J. C., Godinovic, Lelas, N., Plestina, D., Polic, R., Puljak, D., Antunovic, I., Dzelalija, Z., Kovac, M., Brigljevic, M., Duric, V., Kadija, S., Luetic, K., Morovic, J., Attikis, S., Galanti, A., Mousa, M., Nicolaou, J., Ptochos, C., Razis, F., P. A., Finger, Finger, J. r., Assran, M., Ellithi, Kamel, Khalil, A., Mahmoud, S., M. A., Radi, Hektor, A., Kadastik, A., Müntel, M., Raidal, M., Rebane, M., Tiko, L., Azzolini, A., Eerola, V., Fedi, P., Voutilainen, G., Czellar, M., Härkönen, S., Heikkinen, J., Karimäki, A., Kinnunen, V., Kortelainen, R., M. J., Lampén, Lassila, Perini, Lehti, K., Lindén, S., Luukka, T., Mäenpää, P., Peltola, T., Tuominen, T., Tuominiemi, E., Tuovinen, J., Ungaro, E., Wendland, D., Banzuzi, L., Korpela, K., Tuuva, A., Sillou, T., Besancon, D., Choudhury, M., Dejardin, S., Denegri, M., Fabbro, D., Faure, B., L. J., Ferri, Ganjour, F., Givernaud, S., Gras, A., Hamel De Monchenault, Jarry, G., Locci, P., Malcles, E., Millischer, J., Rander, L., Rosowsky, J., Shreyber, A., Titov, I., Baffioni, M., Beaudette, S., Benhabib, F., Bianchini, L., Bluj, L., Broutin, M., Busson, C., Charlot, P., Daci, C., Dahms, N., Dobrzynski, T., Elgammal, L., Granier De Cassagnac, Haguenauer, R., Miné, M., Mironov, P., Ochando, C., Paganini, C., Sabes, P., Salerno, D., Sirois, R., Thiebaux, Y., Veelken, C., Zabi, C., Agram, A., J. L., Andrea, Bloch, J., Bodin, D., Brom, D., J. M., Cardaci, Chabert, M., E. C., Collard, Conte, C., Drouhin, E., Ferro, F., Fontaine, C., J. C., Gelé, Goerlach, D., Juillot, U., Karim, P., Bihan, Le, A. C., Van, Hove, Fassi, P., Mercier, F., Baty, D., Beauceron, C., Beaupere, S., Bedjidian, N., Bondu, M., Boudoul, O., Boumediene, G., Brun, D., Chasserat, H., Chierici, J., Contardo, R., Depasse, D., Mamouni, El, Falkiewicz, H., Fay, A., Gascon, J., Gouzevitch, S., Ille, M., Kurca, B., Grand, Le, Lethuillier, T., Mirabito, M., Perries, L., Sordini, S., Tosi, V., Tschudi, S., Verdier, Y., Viret, P., Lomidze, S., Anagnostou, D., Beranek, G., Edelhoff, S., Feld, M., Heracleous, L., Hindrichs, N., Jussen, O., Klein, R., Merz, K., Ostapchuk, J., Perieanu, A., Raupach, A., Sammet, F., Schael, J., Sprenger, S., Weber, D., Wittmer, H., Zhukov, B., Ata, V., Caudron, M., Dietz, Laursonn, Erdmann, E., Güth, M., Hebbeker, A., Heidemann, T., Hoepfner, C., Klimkovich, K., Klingebiel, T., Kreuzer, D., Lanske, P., Lingemann, D., Magass, J., Merschmeyer, C., Meyer, M., Olschewski, A., Papacz, M., Pieta, P., Reithler, H., Schmitz, H., S. 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M., Rosin, Salfeld, Nebgen, Schmidt, J., Schoerner, Sadenius, Sen, T., Spiridonov, N., Stein, A., Tomaszewska, M., Walsh, J., Wissing, R., Autermann, C., Blobel, C., Bobrovskyi, V., Draeger, S., Enderle, J., Ere, H., Gebbert, J., Görner, U., Hermanns, M., Höing, T., R. S., Kaschube, Kaussen, K., Kirschenmann, G., Klanner, H., Lange, R., Mura, J., Nowak, B., Pietsch, F., Sander, N., Schettler, C., Schleper, H., Schlieckau, P., Schmidt, E., Schröder, A., Schum, M., Stadie, T., Steinbrück, H., Thomsen, G., Barth, J., Berger, C., Chwalek, J., Boer, De, Dierlamm, W., Dirkes, A., Feindt, G., Gruschke, M., Guthoff, J., Hackstein, M., Hartmann, C., Heinrich, F., Held, M., Hoffmann, H., K. H., Honc, Katkov, S., Komaragiri, I., R. J., Kuhr, Martschei, T., Mueller, D., Müller, S., T. h., Niegel, Nürnberg, M., Oberst, A., Oehler, O., Ott, A., Peiffer, J., Quast, T., Rabbertz, G., Ratnikov, K., Ratnikova, F., Renz, N., Röcker, M., Saout, S., Scheurer, C., Schieferdecker, A., Schilling, P., F. P., Schmanau, Schott, M., Simonis, G., H. J., Stober, F. M., Troendle, Wagner, Kuhr, Weiler, J., Zeise, T., Ziebarth, M., E. B., Daskalakis, Geralis, G., Kesisoglou, T., Kyriakis, S., Loukas, A., Manolakos, D., Markou, I., Markou, A., Mavrommatis, C., Ntomari, C., Gouskos, E., Mertzimekis, L., T. J., Panagiotou, Saoulidou, A., Stiliaris, N., Evangelou, E., Foudas, I., Kokkas, C., Manthos, P., Papadopoulos, N., Patras, I., Triantis, V., F. A., Aranyi, Bencze, A., Boldizsar, G., Hajdu, L., Hidas, C., Horvath, P., Kapusi, D., Krajczar, A., Sikler, K., Veszpremi, F., Vesztergombi, V., Beni, G., Molnar, N., Palinkas, J., Szillasi, J., Karancsi, Z., Raics, J., Trocsanyi, P., L. Z., Ujvari, Beri, B., S. B., Bhatnagar, Dhingra, V., Gupta, N., Jindal, R., Kaur, M., Kohli, M., J. M., Mehta, M. Z., Nishu, Saini, N., L. K., Sharma, Singh, A., A. P., Singh, Singh, J., S. P., Ahuja, Choudhary, S., B. C., Kumar, Kumar, A., Malhotra, A., Naimuddin, S., Ranjan, M., Sharma, K., Shivpuri, V., R. K., Banerjee, Bhattacharya, S., Dutta, S., Gomber, S., Jain, B., Khurana, S., Sarkar, R., Choudhury, S., R. K., Dutta, Kailas, D., Kumar, S., Mohanty, V., A. K., Pant, L. M., Shukla, Aziz, P., Ganguly, T., Guchait, S., Gurtu, M., Maity, A., Majumder, M., Mazumdar, G., Mohanty, K., G. B., Parida, Saha, B., Sudhakar, A., Wickramage, K., Banerjee, N., Dugad, S., Mondal, S., N. K., Arfaei, Bakhshiansohi, H., Etesami, H., S. M., Fahim, Hashemi, A., Hesari, M., Jafari, H., Khakzad, A., Mohammadi, M., Mohammadi, Najafabadi, Paktinat, Mehdiabadi, Safarzadeh, S., Zeinali, B., Abbrescia, M., Barbone, M., Calabria, L., Chhibra, C., S. S., Colaleo, Creanza, A., Filippis, De, Palma, De, Fiore, M., Iaselli, L., Lusito, G., Maggi, L., Maggi, G., Manna, M., Marangelli, N., My, B., Nuzzo, S., Pacifico, S., Pompili, N., Pugliese, A., Romano, G., Selvaggi, F., Silvestris, G., Singh, L., Tupputi, G., Zito, S., Abbiendi, G., Benvenuti, G., A. C., Bonacorsi, Braibant, Giacomelli, Brigliadori, S., Capiluppi, L., Castro, P., Cavallo, A., F. R., Cuffiani, Dallavalle, M., G. M., Fabbri, Fanfani, F., Fasanella, A., Giacomelli, D., Grandi, P., Marcellini, C., Masetti, S., Meneghelli, G., Montanari, M., Navarria, A., F. L., Odorici, Perrotta, F., Primavera, A., Rossi, F., A. M., Rovelli, Siroli, T., Travaglini, G., Albergo, R., Cappello, S., Chiorboli, G., Costa, M., Potenza, S., Tricomi, R., Tuve, A., Barbagli, C., Ciulli, G., Civinini, V., D'Alessandro, C., Focardi, R., Frosali, E., Gallo, S., Gonzi, E., Meschini, S., Paoletti, M., Sguazzoni, S., Tropiano, G., Benussi, A., Bianco, L., Colafranceschi, S., Fabbri, S., Piccolo, F., Fabbricatore, D., Musenich, P., Benaglia, R., Guio, De, Matteo, Di, Fiorendi, L., Gennai, S., Ghezzi, S., Malvezzi, A., Manzoni, S., R. A., Martelli, Massironi, A., Menasce, A., Moroni, D., Paganoni, L., Pedrini, M., Ragazzi, D., Redaelli, S., Sala, N., Tabarelli De Fatis, Buontempo, T., Carrillo, Montoya, C. A., Cavallo, Cosa, De, Dogangun, A., Fabozzi, O., Iorio, F., A. O. M., Lista, Merola, L., Paolucci, M., Azzi, P., Bacchetta, P., Bellan, N., Bisello, P., Branca, D., Carlin, A., Checchia, R., Dorigo, P., Dosselli, T., Gasparini, U., Gasparini, F., Gozzelino, U., Kanishchev, A., Lacaprara, K., Lazzizzera, S., Margoni, I., Mazzucato, M., Meneguzzo, M., A. T., Montecassiano, Nespolo, F., Perrozzi, M., Pozzobon, L., Ronchese, N., Simonetto, P., Torassa, F., Tosi, E., Vanini, M., Zotto, S., Zumerle, P., Baesso, G., Berzano, P., Gabusi, U., Ratti, M., S. P., Riccardi, Torre, C., Vitulo, P., Viviani, P., Biasini, C., Bilei, M., G. M., Caponeri, Fanò, B., Lariccia, L., Lucaroni, P., Mantovani, A., Menichelli, G., Nappi, M., Romeo, A., Santocchia, F., Taroni, A., Valdata, S., Azzurri, M., Bagliesi, P., Boccali, G., Broccolo, T., Castaldi, G., D'Agnolo, R., R. T., Dell'Orso, Fiori, R., Foà, F., Giassi, L., Kraan, A., Ligabue, A., Lomtadze, F., Martini, T., Messineo, ALBERTO MARIA, Palla, F., Palmonari, F., Rizzi, Andrea, Serban, A. T., Spagnolo, P., Tenchini, R., Tonelli, GUIDO EMILIO, Venturi, A., Verdini, P. G., Barone, L., Cavallari, F., Del, Re, Diemoz, D., Fanelli, M., Franci, C., Grassi, D., Longo, M., Meridiani, E., Micheli, P., Nourbakhsh, F., Organtini, S., Pandolfi, G., Paramatti, F., Rahatlou, R., Sigamani, S., Soffi, M., Amapane, L., Arcidiacono, N., Argiro, R., Arneodo, S., Biino, M., Botta, C., Cartiglia, C., Castello, N., Costa, R., Demaria, M., Graziano, N., Mariotti, A., Maselli, C., Migliore, S., Monaco, E., Musich, V., Obertino, M., M. M., Pastrone, Pelliccioni, N., Potenza, M., Romero, A., Ruspa, A., Sacchi, M., Sola, R., Solano, V., Staiano, A., Vilela, Pereira, Belforte, A., Cossutti, S., Della, Ricca, Gobbo, G., Marone, B., Montanino, M., Penzo, D., Heo, A., S. G., Nam, S. K., Chang, Chung, S., Kim, J., D. H., Kim, G. N., Kim, J. E., Kong, D. J., Park, Ro, H., S. R., Son, D. C., Kim, J. Y., Kim, Z. J., Song, Jo, S., H. Y., Choi, Gyun, S., Hong, D., Jo, B., Kim, M., Kim, H., T. J., Lee, K. S., Moon, D. H., Park, S. K., Seo, Sim, E., K. S., Choi, Kang, M., Kim, S., J. H., Park, Park, C., I. C., Park, Ryu, S., Cho, G., Choi, Y., Y. K., Goh, M. S., Lee, Lee, B., Lee, J., Seo, S., Yu, H., Bilinskas, I., M. J., Grigelionis, Janulis, I., Castilla, Valdez, De La Cruz Burelo, Heredia De La Cruz, Lopez, Fernandez, Magaña, Villalba, Martínez, Ortega, Sánchez, Hernández, Villasenor, Cendejas, L. M., Carrillo, Moreno, Vazquez, Valencia, Salazar, Ibarguen, H. A., Casimiro, Linares, Morelos, Pineda, Reyes, Santos, M. A., Krofcheck, Bell, D., A. J., Butler, P. H., Doesburg, Reucroft, R., Silverwood, S., Ahmad, H., Asghar, M., M. I., Hoorani, H. R., Khalid, Khan, S., W. A., Khurshid, Qazi, T., Shah, S., M. A., Shoaib, Brona, M., Cwiok, G., Dominik, M., Doroba, W., Kalinowski, K., Konecki, A., Krolikowski, M., Bialkowska, J., Boimska, H., Frueboes, B., Gokieli, T., Górski, R., Kazana, M., Nawrocki, M., Romanowska, Rybinska, Szleper, K., Wrochna, M., Zalewski, G., Almeida, P., Bargassa, N., David, P., Faccioli, A., Ferreira, Parracho, P. G., Gallinaro, Musella, M., Nayak, P., Pela, A., Ribeiro, J., P. Q., Seixas, Varela, J., Vischia, J., Afanasiev, P., Belotelov, S., Bunin, I., Gavrilenko, P., Golutvin, M., Gorbunov, I., Kamenev, I., Karjavin, A., Kozlov, V., Lanev, G., Moisenz, A., Palichik, P., Perelygin, V., Shmatov, V., Smirnov, S., Volodko, V., Zarubin, A., Evstyukhin, A., Golovtsov, S., Ivanov, V., Kim, Y., Levchenko, V., Murzin, P., Oreshkin, V., Smirnov, V., Sulimov, I., Uvarov, V., Vavilov, L., Vorobyev, S., Vorobyev, A., A. n., Andreev, Y. u., Dermenev, Gninenko, A., Golubev, S., Kirsanov, N., Krasnikov, M., Matveev, N., Pashenkov, V., Toropin, A., Troitsky, A., Epshteyn, S., Erofeeva, V., Gavrilov, M., Kossov, V., Krokhotin, M., Lychkovskaya, A., Popov, N., Safronov, V., Semenov, G., Stolin, S., Vlasov, V., Zhokin, E., Belyaev, A., Boos, A., Dubinin, E., Dudko, M., Ershov, L., Gribushin, A., Kodolova, A., Lokhtin, O., Markina, I., Obraztsov, A., Perfilov, S., Petrushanko, M., Sarycheva, S., Savrin, L., Snigirev, V., Andreev, A., Azarkin, V., Dremin, M., Kirakosyan, I., Leonidov, M., Mesyats, A., Rusakov, G., S. V., Vinogradov, Azhgirey, A., Bayshev, I., Bitioukov, I., Grishin, S., Kachanov, V., Konstantinov, V., Korablev, D., Krychkine, A., Petrov, V., Ryutin, V., Sobol, R., Tourtchanovitch, A., Troshin, L., Tyurin, S., Uzunian, N., Volkov, A., Adzic, A., Djordjevic, P., Ekmedzic, M., Krpic, M., Milosevic, D., Aguilar, Benitez, Alcaraz, Maestre, Arce, J., Battilana, P., Calvo, C., Cerrada, E., Chamizo, Llatas, Colino, M., De La Cruz, Delgado, Peris, Diez, Pardos, Domínguez, Vázquez, Fernandez, Bedoya, Fernández, Ramos, J. P., Ferrando, Flix, A., Fouz, J., M. C., Garcia, Abia, Gonzalez, Lopez, Goy, Lopez, Hernandez, S., J. M., Josa, M. I., Merino, Puerta, Pelayo, Redondo, J., Romero, I., Santaolalla, L., Soares, J., M. S., Willmott, Albajar, C., Codispoti, C., Trocóniz, De, J. F., Cuevas, Fernandez, Menendez, Folgueras, J., Gonzalez, Caballero, Lloret, Iglesias, Piedra, Gomez, Vizan, Garcia, J. M., Brochero, Cifuentes, J. A., Cabrillo, I. J., Calderon, Chuang, A., S. H., Duarte, Campderros, Felcini, J., Fernandez, M., Gomez, M., Gonzalez, Sanchez, Jorda, J., Lobelle, Pardo, Lopez, Virto, Marco, A., Marco, J., Martinez, Rivero, Matorras, C., Munoz, Sanchez, F. J., Rodrigo, Rodríguez, Marrero, A. Y., Ruiz, Jimeno, Scodellaro, A., Sobron, Sanudo, Vila, M., Vilar, Cortabitarte, Abbaneo, R., Auffray, D., Auzinger, E., Baillon, G., Ball, P., A. H., Barney, Bernet, D., Bialas, C., Bianchi, W., Bloch, G., Bocci, P., Breuker, A., Bunkowski, H., Camporesi, K., Cerminara, T., Christiansen, G., Coarasa, Perez, J. A., Curé, D'Enterria, B., Roeck, De, Guida, Di, Dobson, S., Dupont, Sagorin, Elliott, Peisert, Frisch, A., Funk, B., Gaddi, W., Georgiou, A., Gerwig, G., Giffels, H., Gigi, M., Gill, D., Giordano, K., Giunta, D., Glege, M., Gomez Reino Garrido, Govoni, R., Gowdy, P., Guida, S., Guiducci, R., Hansen, L., Harris, M., Hartl, P., Harvey, C., Hegner, J., Hinzmann, B., Hoffmann, A., H. F., Innocente, Janot, V., Kaadze, P., Karavakis, K., Kousouris, E., Lecoq, K., Lenzi, P., Lourenço, P., Mäki, C., Malberti, T., Malgeri, M., Mannelli, L., Masetti, M., Mavromanolakis, L., Meijers, G., Mersi, F., Meschi, S., Moser, E., Mozer, R., M. U., Mulders, Nesvold, M., Nguyen, E., Orimoto, M., Orsini, T., Palencia, Cortezon, Perez, E., Petrilli, E., Pfeiffer, A., Pierini, A., Pimiä, M., Piparo, M., Polese, D., Quertenmont, G., Racz, L., Reece, A., Rodrigues, Antunes, Rolandi, J., Rommerskirchen, G., Rovelli, T., Rovere, C., Sakulin, M., Santanastasio, H., Schäfer, F., Schwick, C., Segoni, C., Sharma, I., Siegrist, A., Silva, P., Simon, P., Sphicas, M., Spiga, P., Spiropulu, D., Stoye, M., Tsirou, M., Veres, A., G. I., Vichoudis, Wöhri, P., H. K., Worm, S. D., Zeuner, W. D., Bertl, Deiters, W., Erdmann, K., Gabathuler, W., Horisberger, K., Ingram, R., Kaestli, Q., H. 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- Subjects
Hadron-Hadron scattering ,Nuclear and High Energy Physics ,CMS experiment ,LHC ,High Energy Physics::Experiment ,Nuclear Experiment - Published
- 2012
6. Study of W boson production in PbPb and pp collisions at √sNN=2.76 TeV
- Author
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Chatrchyan, S., Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., Erö, J., Fabjan, C., Friedl, M., Frühwirth, R., Ghete, V. M., Hammer, J., Hörmann, N., Hrubec, J., Jeitler, M., Kiesenhofer, W., Knünz, V., Krammer, M., Liko, D., Mikulec, I., Pernicka, M., Rahbaran, B., Rohringer, C., Rohringer, H., Schöfbeck, R., Strauss, J., Taurok, A., Wagner, P., Waltenberger, W., Walzel, G., Widl, E., Wulz, C. E., Mossolov, V., Shumeiko, N., Suarez, Gonzalez, Bansal, J., Cornelis, S., Wolf, De, E. A., Janssen, Luyckx, X., Maes, S., Mucibello, T., Ochesanu, L., Roland, S., Rougny, B., Selvaggi, R., Staykova, M., Van, Haevermaet, Van, Mechelen, Van, Remortel, Van, Spilbeeck, Blekman, A., Blyweert, F., D'Hondt, S., Gonzalez, Suarez, Kalogeropoulos, R., Maes, A., Olbrechts, M., Van, Doninck, Van, Mulders, Van, Onsem, G. P., Villella, Charaf, I., Clerbaux, O., Lentdecker, De, Dero, G., Gay, V., A. P. R., Hreus, Léonard, T., Marage, A., P. E., Reis, Thomas, T., Vander, Velde, Vanlaer, C., Wang, P., Adler, J., Beernaert, V., Cimmino, K., Costantini, A., Garcia, S., Grunewald, G., Klein, M., Lellouch, B., Marinov, J., Mccartin, A., Ocampo, Rios, A. A., Ryckbosch, Strobbe, D., Thyssen, N., Tytgat, F., Vanelderen, M., Verwilligen, L., Walsh, P., Yazgan, S., Zaganidis, E., Basegmez, N., Bruno, S., Castello, G., Caudron, R., Ceard, A., Delaere, L., Pree, Du, Favart, T., Forthomme, D., Giammanco, L., Hollar, A., Lemaitre, J., Liao, V., Militaru, J., Nuttens, O., Pagano, C., Perrini, D., Pin, L., Piotrzkowski, A., Schul, K., Vizan, Garcia, J. M., Beliy, Caebergs, N., Daubie, T., Hammad, E., G. H., Alves, G. A., Correa Martins Junior, De Jesus Damiao, Martins, D., Pol, T., M. E., Souza, M. H. G., Aldá, Júnior, W. L., Carvalho, Custódio, W., Costa, Da, E. M., De Oliveira Martins, Fonseca De Souza, Matos, Figueiredo, Mundim, D., Nogima, L., Oguri, H., Prado Da Silva, W. L., Santoro, Soares, Jorge, Sznajder, L., Bernardes, A., C. A., Dias, F. A., Fernandez Perez Tomei, T. R., Gregores, E. M., Lagana, Marinho, C., Mercadante, F., P. G., Novaes, S. F., Padula, S. S., Genchev, Iaydjiev, V., Piperov, P., Rodozov, S., Stoykova, M., Sultanov, S., Tcholakov, G., Trayanov, V., Vutova, R., Dimitrov, M., Hadjiiska, A., Kozhuharov, R., Litov, V., Pavlov, L., Petkov, B., Bian, P., J. G., Chen, G. M., Chen, H. S., Jiang, C. H., Liang, Liang, D., Meng, S., Tao, X., Wang, J., Wang, X., Xiao, Z., Xu, H., Zang, M., Zhang, J., Asawatangtrakuldee, Z., Ban, C., Guo, Y., Guo, S., Li, Y., Liu, W., Mao, S., Qian, Y., S. J., Teng, Wang, H., Zhu, S., Zou, B., Avila, W., Gomez, C., J. P., Gomez, Moreno, Osorio, Oliveros, A. F., Sanabria, J. C., Godinovic, Lelas, N., Plestina, D., Polic, R., Puljak, D., Antunovic, I., Kovac, Z., Brigljevic, M., Duric, V., Kadija, S., Luetic, K., Morovic, J., Attikis, S., Galanti, A., Mavromanolakis, M., Mousa, G., Nicolaou, J., Ptochos, C., Razis, F., P. A., Finger, Finger, M., Assran, M., Elgammal, Y., Ellithi, Kamel, Khalil, A., Mahmoud, S., M. A., Radi, Kadastik, A., Müntel, M., Raidal, M., Rebane, M., Tiko, L., Azzolini, A., Eerola, V., Fedi, P., Voutilainen, G., Härkönen, M., Heikkinen, J., Karimäki, A., Kinnunen, V., Kortelainen, R., M. J., Lampén, Lassila, Perini, Lehti, K., Lindén, S., Luukka, T., Mäenpää, P., Peltola, T., Tuominen, T., Tuominiemi, E., Tuovinen, J., Ungaro, E., Wendland, D., Banzuzi, L., Korpela, K., Tuuva, A., Besancon, T., Choudhury, M., Dejardin, S., Denegri, M., Fabbro, D., Faure, B., J. L., Ferri, Ganjour, F., Givernaud, S., Gras, A., Hamel de Monchenault, Jarry, G., Locci, P., Malcles, E., Millischer, J., Nayak, L., Rander, A., Rosowsky, J., Shreyber, A., Titov, I., Baffioni, M., Beaudette, S., Benhabib, F., Bianchini, L., Bluj, L., Broutin, M., Busson, C., Charlot, P., Daci, C., Dahms, N., Dobrzynski, T., Granier de Cassagnac, Haguenauer, R., Miné, M., Mironov, P., Nguyen, C., Ochando, M., Paganini, C., Sabes, P., Salerno, D., Sirois, R., Veelken, Y., Zabi, C., Agram, A., J. L., Andrea, Bloch, J., Bodin, D., Brom, D., J. M., Cardaci, Chabert, M., E. C., Collard, Conte, C., Drouhin, E., Ferro, F., Fontaine, C., J. C., Gelé, Goerlach, D., Juillot, U., Karim, P., Bihan, Le, A. C., Van, Hove, Fassi, P., Mercier, F., Beauceron, D., Beaupere, S., Bondu, N., Boudoul, O., Brun, G., Chasserat, H., Chierici, J., Contardo, R., Depasse, D., Mamouni, El, Fay, H., Gascon, J., Gouzevitch, S., Ille, M., Kurca, B., Lethuillier, T., Mirabito, M., Perries, L., Sordini, S., Tosi, V., Tschudi, S., Verdier, Y., Viret, P., Tsamalaidze, S., Anagnostou, Z., Beranek, G., Edelhoff, S., Feld, M., Heracleous, L., Hindrichs, N., Jussen, O., Klein, R., Merz, K., Ostapchuk, J., Perieanu, A., Raupach, A., Sammet, F., Schael, J., Sprenger, S., Weber, D., Wittmer, H., Zhukov, B., Ata, V., Caudron, M., Dietz, Laursonn, Duchardt, E., Erdmann, D., Fischer, M., Güth, R., Hebbeker, A., Heidemann, T., Hoepfner, C., Klingebiel, K., Kreuzer, D., Lingemann, P., Magass, J., Merschmeyer, C., Meyer, M., Olschewski, A., Papacz, M., Pieta, P., Reithler, H., Schmitz, H., S. A., Sonnenschein, Steggemann, L., Teyssier, J., Bontenackels, M., Cherepanov, M., Davids, V., Flügge, M., Geenen, G., Geisler, H., Haj, Ahmad, Hoehle, W., Kargoll, F., Kress, B., Kuessel, T., Linn, Y., Nowack, A., Perchalla, A., Pooth, L., Rennefeld, O., Sauerland, J., Stahl, P., Aldaya, Martin, Behr, M., Behrenhoff, J., Behrens, W., Bergholz, U., Bethani, M., Borras, A., Burgmeier, K., Cakir, A., Calligaris, A., Campbell, L., Castro, A., Costanza, E., Dammann, F., Eckerlin, D., Eckstein, G., Fischer, D., Flucke, D., Geiser, G., Glushkov, A., Gunnellini, I., Habib, P., Hauk, S., Hellwig, J., Jung, G., Kasemann, H., Katsas, M., Kleinwort, P., Kluge, C., Knutsson, H., Krämer, A., Krücker, M., Kuznetsova, D., Lange, E., Lohmann, W., Lutz, W., Mankel, B., Marfin, R., Marienfeld, I., Melzer, Pellmann, I. A., Meyer, A. B., Mnich, Mussgiller, J., Naumann, Emme, Olzem, S., Perrey, J., Petrukhin, H., Pitzl, A., Raspereza, D., Ribeiro, Cipriano, P. M., Riedl, Rosin, C., Salfeld, Nebgen, Schmidt, J., Schoerner, Sadenius, Sen, T., Spiridonov, N., Stein, A., Walsh, M., Wissing, R., Autermann, C., Blobel, C., Bobrovskyi, V., Draeger, S., Enderle, J., Erfle, H., Gebbert, J., Görner, U., Hermanns, M., Höing, T., R. S., Kaschube, Kaussen, K., Kirschenmann, G., Klanner, H., Lange, R., Mura, J., Nowak, B., Peiffer, F., Pietsch, T., Rathjens, N., Sander, D., Schettler, C., Schleper, H., Schlieckau, P., Schmidt, E., Schröder, A., Schum, M., Seidel, T., Stadie, M., Steinbrück, H., Thomsen, G., Barth, J., Berger, C., Böser, J., Chwalek, C., Boer, De, Descroix, W., Dierlamm, A., Feindt, A., Guthoff, M., Hackstein, M., Hartmann, C., Hauth, F., Heinrich, T., Held, M., Hoffmann, H., K. H., Honc, Katkov, S., Komaragiri, I., J. R., Martschei, Mueller, D., Müller, S., Niegel, T., Nürnberg, M., Oberst, A., Oehler, O., Ott, A., Quast, J., Rabbertz, G., Ratnikov, K., Ratnikova, F., Röcker, N., Scheurer, S., Schilling, A., F. P., Schott, Simonis, G., H. J., Stober, F. M., Troendle, Ulrich, D., Wagner, Kuhr, Wayand, J., Weiler, S., Zeise, T., Daskalakis, M., Geralis, G., Kesisoglou, T., Kyriakis, S., Loukas, A., Manolakos, D., Markou, I., Markou, A., Mavrommatis, C., Ntomari, C., Gouskos, E., Mertzimekis, L., T. J., Panagiotou, Saoulidou, A., Evangelou, N., Foudas, I., Kokkas, C., Manthos, P., Papadopoulos, N., Patras, I., Bencze, V., Hajdu, G., Hidas, C., Horvath, P., Krajczar, D., Radics, K., Sikler, B., Veszpremi, F., Vesztergombi, V., Beni, G., Czellar, N., Molnar, S., Palinkas, J., Szillasi, J., Karancsi, Z., Raics, J., Trocsanyi, P., Z. L., Ujvari, Beri, B., S. B., Bhatnagar, Dhingra, V., Gupta, N., Jindal, R., Kaur, M., Mehta, M., M. Z., Nishu, Saini, N., L. K., Sharma, Singh, A., Ahuja, J., Bhardwaj, S., Choudhary, A., B. C., Kumar, Kumar, A., Malhotra, A., Naimuddin, S., Ranjan, M., Sharma, K., Shivpuri, V., R. K., Banerjee, Bhattacharya, S., Dutta, S., Gomber, S., Jain, B., Jain, S., Khurana, S., Sarkar, R., Sharan, S., Abdulsalam, M., Choudhury, A., R. K., Dutta, Kailas, D., Kumar, S., Mehta, V., Mohanty, P., A. K., Pant, L. M., Shukla, Aziz, P., Ganguly, T., Guchait, S., Maity, M., Majumder, M., Mazumdar, G., Mohanty, K., G. B., Parida, Sudhakar, B., Wickramage, K., Banerjee, N., Dugad, S., Arfaei, S., Bakhshiansohi, H., Etesami, H., S. M., Fahim, Hashemi, A., Hesari, M., Jafari, H., Khakzad, A., Mohammadi, M., Mohammadi, Najafabadi, Paktinat, Mehdiabadi, Safarzadeh, S., Zeinali, B., Abbrescia, M., Barbone, M., Calabria, L., Chhibra, C., S. S., Colaleo, Creanzaa, A., Filippis, De, Palmaa, De, Fiore, M., Iaselli, L., Lusito, G., Maggi, L., Maggi, G., Marangelli, M., Mya, B., Nuzzo, S., Pacifico, S., Pompili, N., Pugliese, A., Selvaggi, G., Silvestris, G., Singh, L., Venditti, G., Zito, R., Abbiendi, G., Benvenuti, G., A. C., Bonacorsi, Braibant, Giacomelli, Brigliadori, S., Capiluppi, L., Castro, P., Cavallo, A., F. R., Cuffiani, Dallavalle, M., G. M., Fabbri, Fanfani, F., Fasanella, A., Giacomelli, D., Grandi, P., Guiducci, C., Marcellini, L., Masetti, S., Meneghelli, G., Montanari, M., Avarria, A., F. L., Odorici, Perrottaa, F., Primavera, A., Rossi, F., A. M., Rovelli, Siroli, T., Travaglini, G., Albergo, R., Cappello, S., Chiorboli, G., Costa, M., Potenza, S., Tricomi, R., Tuve, A., Barbagli, C., Ciulli, G., Civinini, V., D'Alessandro, C., Focardi, R., Frosali, E., Gallo, S., Gonzi, E., Meschini, S., Paoletti, M., Sguazzoni, S., Tropiano, G., Benussi, A., Bianco, L., Colafranceschi, S., Fabbri, S., Piccolo, F., Fabbricatore, D., Musenich, P., Benaglia, R., Guio, De, Matteo, Di, Fiorendi, L., Gennai, S., Ghezzi, S., Malvezzi, A., Manzoni, S., R. A., Martelli, Massironi, A., Menascea, A., Moroni, D., Paganoni, L., Pedrini, M., Ragazzi, D., Redaelli, S., Salaa, N., Tabarelli de Fatis, Buontempo, T., Carrillo, Montoya, C. A., Cavallo, Cosa, De, Dogangun, A., Fabozzi, O., Iorio, F., A. O. M., Listaa, Meola, L., Merolaa, S., Paolucci, M., Azzi, P., Bacchetta, P., Bisello, N., Branca, D., Carlin, A., Checchia, R., Dorigo, P., Dosselli, T., Gasparini, U., Gasparini, F., Gozzelino, U., Kanishchev, A., Lacaprara, K., Lazzizzera, S., Margoni, I., Meneguzzo, M., A. T., Pazzini, Perrozzi, J., Pozzobon, L., Ronchese, N., Simonetto, P., Torassa, F., Tosi, E., Vanini, M., Zotto, S., Zucchettaa, P., Zumerle, A., Gabusi, G., Ratti, M., S. P., Riccardi, Torre, C., Vitulo, P., Biasini, P., Bilei, M., G. M., Fanò, Lariccia, L., Lucaroni, P., Mantovani, A., Menichelli, G., Nappi, M., Romeo, A., Saha, F., Santocchia, A., Taroni, A., Azzurri, S., Bagliesi, P., Boccali, G., Broccolo, T., Castaldi, G., D'Agnolo, R., R. T., Dell'Orso, Fiori, R., Foà, F., Giassi, L., Kraan, A., Ligabue, A., Lomtadze, F., Martini, T., Messineo, ALBERTO MARIA, Palla, F., Rizzi, Andrea, Serban, A. T., Spagnolo, P., Squillacioti, P., Tenchini, R., Tonelli, GUIDO EMILIO, Venturi, A., Verdini, P. G., Barone, L., Cavallari, F., Del, Re, Diemoz, D., Grassi, M., Longo, M., Meridiani, E., Micheli, P., Nourbakhsh, F., Organtini, S., Paramatti, G., Rahatlou, R., Sigamani, S., Soffi, M., Amapane, L., Arcidiacono, N., Argiro, R., Arneodo, S., Biino, M., Botta, C., Cartiglia, C., Costa, N., Demaria, M., Graziano, N., Mariotti, A., Maselli, C., Migliore, S., Monaco, E., Musich, V., Obertino, M., M. M., Pastrone, Pelliccioni, N., Potenza, M., Romero, A., Ruspa, A., Sacchi, M., Sola, R., Solano, V., Staiano, A., Vilela, Pereira, Belforte, A., Cossutti, S., Della, Ricca, Gobbo, G., Marone, B., Montanino, M., Penzoa, D., Schizzi, A., Heo, A., S. G., Kim, T. Y., Nam, S. K., Chang, Chung, S., Kim, J., D. H., Kim, G. N., Kong, D. J., Park, Ro, H., S. R., Son, D. C., Son, Kim, T., J. Y., Kim, Z. J., Song, Jo, S., H. Y., Choi, Gyun, S., Hong, D., Jo, B., Kim, M., Kim, H., T. J., Lee, K. S., Moon, D. H., Park, S. K., Choi, Kang, M., Kim, S., J. H., Park, Park, C., I. C., Park, Ryu, S., Cho, G., Choi, Y., Y. K., Goh, M. S., Kwon, Lee, E., Lee, B., Lee, J., Seo, S., Yu, H., Bilinskas, I., M. J., Grigelionis, Janulis, I., Juodagalvis, M., Castilla, Valdez, De La Cruz Burelo, Heredia de La Cruz, Lopez, Fernandez, Magaña, Villalba, Martínez, Ortega, Sánchez, Hernández, Villasenor, Cendejas, L. M., Carrillo, Moreno, Vazquez, Valencia, Salazar, Ibarguen, H. A., Casimiro, Linares, Morelos, Pineda, Reyes, Santos, M. A., Krofcheck, Bell, D., A. J., Butler, P. H., Doesburg, Reucroft, R., Silverwood, S., Ahmad, H., Asghar, M., M. I., Hoorani, H. R., Khalid, Khan, S., W. A., Khurshid, Qazi, T., Shah, S., M. A., Shoaib, Brona, M., Bunkowski, G., Cwiok, K., Dominik, M., Doroba, W., Kalinowski, K., Konecki, A., Krolikowski, M., Bialkowska, J., Boimska, H., Frueboes, B., Gokieli, T., Górski, R., Kazana, M., Nawrocki, M., Romanowska, Rybinska, Szleper, K., Wrochna, M., Zalewski, G., Almeida, P., Bargassa, N., David, P., Faccioli, A., Fernandes, P., Ferreira, Parracho, P. G., Gallinaro, Seixas, M., Varela, J., Vischia, J., Afanasiev, P., Belotelov, S., Bunin, I., Gavrilenko, P., Golutvin, M., Kamenev, I., Karjavin, A., Kozlov, V., Lanev, G., Malakhov, A., Moisenz, A., Palichik, P., Perelygin, V., Shmatov, V., Smirnov, S., Volodko, V., Zarubin, A., Evstyukhin, A., Golovtsov, S., Ivanov, V., Kim, Y., Levchenko, V., Murzin, P., Oreshkin, V., Smirnov, V., Sulimov, I., Uvarov, V., Vavilov, L., Vorobyev, S., Vorobyev, A., Andreev, A., Dermenev, Y., Gninenko, A., Golubev, S., Kirsanov, N., Krasnikov, M., Matveev, N., Pashenkov, V., Tlisov, A., Toropin, D., Epshteyn, A., Erofeeva, V., Gavrilov, M., Kossov, V., Lychkovskaya, M., Popov, N., Safronov, V., Semenov, G., Stolin, S., Vlasov, V., Zhokin, E., Belyaev, A., Boos, A., Ershov, E., Gribushin, A., Klyukhin, A., Kodolova, V., Korotkikh, O., Lokhtin, V., Markina, I., Obraztsov, A., Perfilov, S., Petrushanko, M., Popov, S., Sarycheva, A., Savrin, L., Snigirev, V., Vardanyan, A., Andreev, I., Azarkin, V., Dremin, M., Kirakosyan, I., Leonidov, M., Mesyats, A., Rusakov, G., S. V., Vinogradov, Azhgirey, A., Bayshev, I., Bitioukov, I., Grishin, S., Kachanov, V., Konstantinov, V., Korablev, D., Krychkine, A., Petrov, V., Ryutin, V., Sobol, R., Tourtchanovitch, A., Troshin, L., Tyurin, S., Uzunian, N., Volkov, A., Adzic, A., Djordjevic, P., Ekmedzic, M., Krpic, M., Milosevic, D., Aguilar, Benitez, Alcaraz, Maestre, Arce, J., Battilana, P., Calvo, C., Cerrada, E., Chamizo, Llatas, Colino, M., De La Cruz, Delgado, Peris, Diez, Pardos, Domínguez, Vázquez, Fernandez, Bedoya, Fernández, Ramos, J. P., Ferrando, Flix, A., Fouz, J., M. C., Garcia, Abia, Gonzalez, Lopez, Goy, Lopez, Hernandez, S., J. M., Josa, M. I., Merino, Puerta, Pelayo, Quintario, Olmeda, Redondo, A., Romero, I., Santaolalla, L., Soares, J., M. S., Willmott, Albajar, C., Codispoti, C., Trocóniz, De, J. F., Cuevas, Fernandez, Menendez, Folgueras, J., Gonzalez, Caballero, Lloret, Iglesias, Piedra, Gomez, Brochero, Cifuentes, J. A., Cabrillo, I. J., Calderon, Chuang, A., S. H., Duarte, Campderros, Felcini, J., Fernandez, M., Gomez, M., Gonzalez, Sanchez, Jorda, J., Lobelle, Pardo, Lopez, Virto, Marco, A., Marco, J., Martinez, Rivero, Matorras, C., Munoz, Sanchez, F. J., Rodrigo, Rodríguez, Marrero, A. Y., Ruiz, Jimeno, Scodellaro, A., Sobron, Sanudo, Vila, M., Vilar, Cortabitarte, Abbaneo, R., Auffray, D., Auzinger, E., Baillon, G., Ball, P., A. H., Barney, Bernet, D., Bianchi, C., Bloch, G., Bocci, P., Bonato, A., Breuker, A., Camporesi, H., Cerminara, T., Christiansen, G., Coarasa, Perez, J. A., D'Enterria, Dabrowski, D., Roeck, De, Guida, Di, Dobson, S., Dupont, Sagorin, Elliott, Peisert, Frisch, A., Funk, B., Georgiou, W., Giffels, G., Gigi, M., Gill, D., Giordano, K., Giunta, D., Glege, M., Gomez Reino Garrido, Govoni, R., Gowdy, P., Guida, S., Hansen, R., Harris, M., Hartl, P., Harvey, C., Hegner, J., Hinzmann, B., Innocente, A., Janot, V., Kaadze, P., Karavakis, K., Kousouris, E., Lecoq, K., Lee, P., Y. J., Lenzi, Lourenço, P., Mäki, C., Malberti, T., Malgeri, M., Mannelli, L., Masetti, M., Meijers, L., Mersi, F., Meschi, S., Moser, E., Mozer, R., M. U., Mulders, Musella, M., Nesvold, P., Orimoto, E., Orsini, T., Palencia, Cortezon, Perez, E., Petrilli, E., Pfeiffer, A., Pierini, A., Pimiä, M., Piparo, M., Polese, D., Quertenmont, G., Racz, L., Reece, A., Rodrigues, Antunes, Rolandi, J., Rommerskirchen, G., Rovelli, T., Rovere, C., Sakulin, M., Santanastasio, H., Schäfer, F., Schwick, C., Segoni, C., Sekmen, I., Sharma, S., Siegrist, A., Silva, P., Simon, P., Sphicas, M., Spiga, P., Spiropulu, D., Stoye, M., Tsirou, M., Veres, A., G. I., Vlimant, J. R., Wöhri, H. K., Worm, S. D., Zeuner, W. D., Bertl, Deiters, W., Erdmann, K., Gabathuler, W., Horisberger, K., Ingram, R., Kaestli, Q., H. C., König, Kotlinski, S., Langenegger, D., Meier, U., Renker, F., Rohe, D., Sibille, T., Bäni, J., Bortignon, L., Buchmann, P., M. A., Casal, Chanon, B., Deisher, N., Dissertori, A., Dittmar, G., Dünser, M., Eugster, M., Freudenreich, J., Grab, K., Hits, C., Lecomte, D., Lustermann, P., Marini, W., Martinez Ruiz del Arbol, Mohr, P., Moortgat, N., Nägeli, F., Nef, C., Nessi, Tedaldi, Pandolfi, F., Pape, F., Pauss, L., Peruzzi, F., Ronga, M., F. J., Rossini, Sala, M., Sanchez, L., A. K., Starodumov, Stieger, A., Takahashi, B., Tauscher, M., Thea, L., Theofilatos, A., Treille, K., Urscheler, D., Wallny, C., Weber, R., H. A., Wehrli, Aguilo, L., Amsler, E., Chiochia, C., Visscher, De, Favaro, S., Ivova, Rikova, Millan, Mejias, Otiougova, B., Robmann, P., Snoek, P., Tupputi, H., Verzetti, S., Chang, M., Y. H., Chen, K. H., Kuo, C. M., Li, S. W., Lin, Z. K., Lu, Y. J., Mekterovic, Singh, D., A. P., Volpe, Yu, R., S. S., Bartalini, Chang, P., Y. H., Chang, Y. W., Chao, Chen, Y., K. F., Dietz, Grundler, C., Hou, U., W. S., Hsiung, Kao, Y., K. Y., Lei, Y. J., Lu, R. S., Majumder, Petrakou, D., Shi, E., Shiu, X., J. 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- Subjects
Heavy-ions ,Nuclear and High Energy Physics ,Heavy Ion collision ,CMS experiment ,ROOT-S=7 TEV ,Physics::Instrumentation and Detectors ,CMS ,Physics ,ATLAS DETECTOR ,W bosons ,HEAVY-ION COLLISIONS ,PRODUCTION CROSS-SECTION ,Physics and Astronomy ,High Energy Physics::Experiment ,LHC ,Nuclear Experiment - Abstract
A measurement is presented of W-boson production in PbPb collisions carried out at a nucleon-nucleon (NN) centre-of-mass energy root S-NN of 2.76 TeV at the LHC using the CMS detector. In data corresponding to an integrated luminosity of 7.3 mu b(-1), the number of W -> mu v(mu) decays is extracted in the region of muon pseudorapidity vertical bar eta mu vertical bar < 2.1 and transverse momentum p(T)(mu) > 25 GeV/c. Yields of muons found per unit of pseudorapidity correspond to (159 +/- 10(stat.) +/- 12(syst.)) x 10(-8) W and (154 +/- 10(stat.) +/- 12(syst.)) x 10(-8) W- bosons per minimum-bias PbPb collision. The dependence of W production on the centrality of PbPb collisions is consistent with a scaling of the yield by the number of incoherent NN collisions. The yield of W bosons is also studied in a sample of pp interactions at root S = 2.76 TeV corresponding to an integrated luminosity of 231 nb(-1). The individual W+ and W- yields in PbPb and pp collisions are found to agree, once the neutron and proton content in Pb nuclei is taken into account. Likewise, the difference observed in the dependence of the positive and negative muon production on pseudorapidity is consistent with next-to-leading-order perturbative QCD calculations.
- Published
- 2012
7. Pathologic analysis of capsular and incisional denudation and positive margin status in the development of a robot-assisted laparoscopic prostatectomy program.
- Author
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Williams, Stephen, Sutherland, D., Frazier, H., Schwartz, A., and Engel, J.
- Abstract
The aim of this study is to explore the use of pathologically confirmed capsular incision and denudation as a measure of adequacy of extirpation following robot-assisted laparoscopic prostatectomy (RALP). All patients who underwent RALP at the George Washington University Medical Center during the first 2 years of inception of the robotic prostatectomy program were included. All pathologic specimens were reviewed by a single pathologist. One hundred twenty-eight men who underwent RALP during the first 2 years were identified. Sixty-four patients underwent RALP during the first year (group 1) and all pathologic specimens were reviewed retrospectively. Sixty-four patients underwent RALP during the second year (group 2) after revision of our operative technique and all pathologic specimens were reviewed prospectively. Of patients in group 1, 18 (28%) had a positive surgical margin (PSM), and 18 (28%) with negative surgical margins were found to have capsular incision or denudation. In group 1, 32 (50%) patients had evidence of iatrogenic capsular violation. Group 2 consisted of 13 (20%) patients with a PSM and 9 (14%) margin-negative patients with capsular incision or denudation. Group 2 had a total of 22 (34%) patients with evidence of iatrogenic capsular violation. Overall reduction in positive margins was not statistically significant between the groups. Improvement in capsular incision/denudation rate and overall capsular violation between the two groups was statistically significant ( P < 0.03 and <0.0055). Surgical margin status alone underestimates the overall quality of surgical resection after RALP because not all capsular violations result in a PSM. Surgeon-guided pathologic review in addition to intraoperative experience may improve oncologic success during the RALP learning curve. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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8. Gigabit Ethernet: from 100 to 1,000 Mbps.
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Frazier, H. and Johnson, H.
- Published
- 1999
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9. The diagnosis of syncope in the elderly.
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Frazier, Howard S. and Frazier, H S
- Published
- 1993
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10. Assessing the effectiveness of ambulatory cardiac monitoring for specific clinical indications. Introduction.
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Adams, Miriam E., Antczak-Bouckoms, Alexia, Frazier, Howard S., Lau, Joseph, Chalmers, Thomas C., Mosteller, Frederick, Adams, M E, Antczak-Bouckoms, A, Frazier, H S, Lau, J, Chalmers, T C, and Mosteller, F
- Published
- 1993
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11. Clinical variables which serve as predictors of cancer-specific survival among patients treated with radical cystectomy for transitional cell carcinoma of the bladder and prostate.
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Thrasher, J. Brantley, Frazier, Harold A., Robertson, Judith E., Dodge, Richard K., Paulson, David F., Thrasher, J B, Frazier, H A, Robertson, J E, Dodge, R K, and Paulson, D F
- Published
- 1994
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12. Testicular cancer in blacks. A multicenter experience.
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Moul, Judd W., Schanne, Francis J., Thompson, Ian M., Frazier, Harold A., Peretsman, Samuel A., Wettlaufer, John N., Rozanski, Thomas A., Stack, Richard S., Kreder, Karl J., Hoffman, Kenneth J., Moul, J W, Schanne, F J, Thompson, I M, Frazier, H A, Peretsman, S A, Wettlaufer, J N, Rozanski, T A, Stack, R S, Kreder, K J, and Hoffman, K J
- Published
- 1994
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13. The value of pathologic factors in predicting cancer-specific survival among patients treated with radical cystectomy for transitional cell carcinoma of the bladder and prostate.
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Frazier, Harold A., Robertson, Judith E., Dodge, Richard K., Paulson, David F., Frazier, H A, Robertson, J E, Dodge, R K, and Paulson, D F
- Published
- 1993
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14. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate-specific antigen levels.
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Humphrey, Peter A., Frazier, Harold A., Vollmer, Robin T., Paulson, David F., Humphrey, P A, Frazier, H A, Vollmer, R T, and Paulson, D F
- Published
- 1993
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15. Does radical prostatectomy in the presence of positive pelvic lymph nodes enhance survival?
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Frazier, H., Robertson, J., and Paulson, D.
- Abstract
A retrospective review was performed on all patients with stage D1 prostate cancer treated at Duke University Medical Center between 1975 and 1989. A total of 156 patients underwent staging pelvic lymph-node dissection for clinically organ-confined prostate cancer (stage A or B) but were found to have disease metastatic to the pelvic lymph nodes (stage D1). Of this population, 42 patients also underwent radical prostatectomy (group 1), leaving 114 who did not have their prostate removed (group 2). The median cancer-specific survival was 11.2 years for group 1 versus 5.8 years for group 2 ( P=0.005). In patients with one or two positive lymph nodes the median cancer-specific survival was 10.2 years for group 1 versus 5.9 years for group 2 ( P=0.015). There was no difference in survival if three or more lymph nodes were positive. Adjuvant treatment with immediate androgen deprivation and/or postoperative radiation therapy failed to improve the survival experience. The incidence of local problems, including stricture formation, bleeding, or regrowth of cancer requiring dilation or surgical intervention (transurethral prostatectomy) averaged 9.5% in group 1 and 24.6% in group 2. These data show that patients with limited node-positive disease selected for radical prostatectomy experience a survival advantage over those denied such therapy and that this advantage is independent of adjunctive therapy. [ABSTRACT FROM AUTHOR]
- Published
- 1994
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16. Correction of postoperative metabolic alkalosis and renal failure by hemodialysis.
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Swartz, Richard, Rubin, James, Brown, Robert, Yager, Henry, Steinman, Theodore, Frazier, Howard, Swartz, R D, Rubin, J E, Brown, R S, Yager, J M, Steinman, T I, and Frazier, H S
- Subjects
HEMODIALYSIS ,ALKALOSIS ,ACUTE kidney failure ,THERAPEUTICS - Abstract
Three postoperative patients with oliguirc renal failure and hypochloremic metabolic alkalosis were treated with hemodialysis using a specailly prepared high-chloride, low-acetate dialysate. This mode of therapy corrected the metabolic abnormalities and was significantly more effective than treatment with commercially available high-acetate dialysate at increasing the serum chloride and hydrogen ion concentration. Furthermore, hemodialysis with high-chloride, low-acetate dialysate corrected the clinical sequelae of hypoventilation, cardiac arrhythmia, and neuromuscular irritability associated with metabolic alkalosis while treating uremia simultaneously. [ABSTRACT FROM AUTHOR]
- Published
- 1977
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17. Thyroxine-antifertility steroids interrelations in the albino rat
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Moses, H. A., Winfield, J. K., Frazier, H. M., and Ashhurst, J. C.
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Ovulation ,Thyroxine ,Ovarian Follicle ,Animals ,Female ,Blood Proteins ,Lipase ,In Vitro Techniques ,Research Article ,Contraceptives, Oral ,Rats - Published
- 1969
18. Effect of an antifertility preparation on a fibrinogen-fibrinolysin system in vitro
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Moses, H. A., Frazier, H. M., and Field, R. M.
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Fibrinogen ,Fibrinolysin ,Blood Coagulation ,Research Article ,Contraceptives, Oral - Published
- 1969
19. Biochemical effects of an anti-fertility preparation
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Moses, H. A., Schwartz, B., Burstein, A., and Frazier, H. M.
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Ovulation ,Animals ,Hyaluronoglucosaminidase ,Female ,In Vitro Techniques ,Research Article ,Contraceptives, Oral ,Rats - Published
- 1967
20. GROUP B STREPTOCOCCAL CELLULITIS-ADENITIS IN A PREVIOUSLY NORMAL CHILD.
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Brook, Itzhak and Frazier, H.
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- 1992
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21. NEPTUNE gigabit Ethernet submarine cable system.
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Maffei, A.R., Chave, A.D., Massion, G., White, S.N., Bailey, J., Lerner, S., Bradley, A., Yoerger, D., Frazier, H., and Buddenberg, R.
- Published
- 2001
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22. A Physiologic Pulsatile Cardiopulimonary Bypass Pump System For Neonates And Infants.
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Undar, A., Inman, R., Kadipasaoglu, K., Frazier, H., and Fraser, C.D.
- Published
- 1998
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23. Focal Boosted IMRT Treatment of Prostate Cancer to 84 Gy in 28 Fractions: Preliminary Clinical Outcomes and Dosimetry.
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Hands, J.M., Whalen, M., Haji-Momenian, S., Frazier, H., Andrawis, R., Jarrett, T., Provenzano, D., Bauman, J.E., Estephan, F., Aghdam, H., Chen, D., Goyal, S., Ojong-Ntui, M., and Rao, Y.J.
- Subjects
- *
MEDICAL dosimetry , *PROSTATE cancer , *TREATMENT effectiveness , *CANCER treatment , *SEMINAL vesicles , *INTENSITY modulated radiotherapy - Abstract
The FLAME trial reported that focal boosting of prostate tumor to 95 Gy in 35 fractions improves biochemical control. However, this treatment is not commonly used in the United States. We investigated a focally boosted treatment of 84 Gy in 28 fractions (EQD2 108 Gy, BED 252 Gy). Between 2019-2022, men with unfavorable intermediate risk (uIR) and high risk (HR) prostate cancer were enrolled on a prospective registry and received a novel IMRT regimen. The dose levels were 84 Gy to the gross tumor volume (GTV) as defined on mpMRI (T2W and ADC) with no added margin, 70 Gy to the prostate and proximal seminal vesicles, and optional 50.4 Gy to elective pelvic lymph nodes (all 28 fractions). Patients received fiducial markers and hydrogel spacer. The treatment planning goal was to cover 95% of the GTV at 84 Gy, and also meet the target and normal tissue dosimetry criteria of the hypofractionated treatment arm of NRG-GU005. VMAT was used for treatment delivery. ADT was given at the discretion of the treating physician. A total of 20 men were included in the study, 2 (10%) uIR and 18 (90%) HR. 9 (45%) tumors were GS 7, 7 (35%) were GS 8, and 4 (20%) were GS 9. There were 13 (65%) stage cT1, 4 (20%) cT2 and 3 (15%) cT3. One (5%) patient received short term ADT, 18 (95%) long term ADT, and 1 (5%) refused ADT. 18 (90%) men received elective nodal radiation. The mean baseline PSA was 25.1 (range 4.2-73.4). The median baseline IPSS score was 11.1 (IQR 4.5-12), and 4 patients had severe baseline urinary symptoms (IPSS ≥20). The mean baseline prostate volume was 57.4 cc (range 26.8-198.3). The mean volume of the 84 Gy boost target was 7.1 cc (range 2.3-15.0) and the mean proportion of the prostate boosted was 14.8% (range 2% - 47%). There were 10 (50%) men with 1 boost target, 6 (30%) with two, 3 (15%) with three, and 1 (5%) had 4 boost targets. Targets were located in peripheral zone (85%), transition zone (30%), and central zone (5%). Patients met all per-protocol normal tissue criteria of NRG-GU005, except for bladder D0.03cc. The mean±SD (Gy) rectum D15%, D25%, and D30% were 51±5, 45±5, 42±4. The mean±SD (Gy) bladder D0.03cc, D30%, D50% were 79±4, 50±8, 38±10. At a median follow up time of 21.3 months (range 7.1-38.2), no patients have developed biochemical progression, local recurrence, distant progression, or death from prostate cancer. One patient died at 18 months from metastatic colorectal cancer, unrelated to prostate cancer treatment. Acute grade 1-2 GU toxicity occurred in 13 (65%) patients, and acute grade 1-2 GI toxicity occurred in 4 (20%) patients. No patients developed grade 3+ acute or late GU or GI toxicity. Two patients required temporary foley catheter for obstruction during RT, and both had IPSS >20 at baseline. The patient who refused ADT had a PSA bounce of magnitude 2.2 ng/mL at 14 months, PSA values declined without additional treatment. A novel 28-fraction focal boosted IMRT treatment is feasible and has an acceptable early toxicity profile. Oncologic results are promising but require longer follow up. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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24. Essential Factors for a Healthy Microbiome: A Scoping Review.
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Grace-Farfaglia P, Frazier H, and Iversen MD
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- Diet, Fatty Acids, Volatile metabolism, Humans, Metagenome, Gastrointestinal Microbiome physiology, Microbiota
- Abstract
Recent discoveries of the purpose and potential of microbial interactions with humans have broad implications for our understanding of metabolism, immunity, the host−microbe genetic interactions. Bioavailability and bioaccessibility of phytonutrients in foods not only enrich microbial diversity in the lower human gastrointestinal tract (GIT) but also direct the functioning of the metagenome of the microbiota. Thus, healthy choices must include foods that contain nutrients that satisfy both the needs of humans and their microbes. Physical activity interventions at a moderate level of intensity have shown positive effects on metabolism and the microbiome, while intense training (>70% VO2max) reduces diversity in the short term. The microbiome of elite endurance athletes is a robust producer of short-chain fatty acids. A lifestyle lacking activity is associated with the development of chronic disease, and experimental conditions simulating weightlessness in humans demonstrate loss of muscle mass occurring in conjunction with a decline in gut short-chain fatty acid (SCFA) production and the microbes that produce them. This review summarizes evidence addressing the relationship between the intestinal microbiome, diet, and physical activity. Data from the studies reviewed suggest that food choices and physical fitness in developed countries promote a resource “curse” dilemma for the microbiome and our health.
- Published
- 2022
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- View/download PDF
25. Insulin Receptor Plasma Membrane Levels Increased by the Progesterone Receptor Membrane Component 1.
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Hampton KK, Anderson K, Frazier H, Thibault O, and Craven RJ
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- A549 Cells, Cell Line, Tumor, Glucose Transporter Type 1 metabolism, Glucose Transporter Type 4 metabolism, Humans, Progesterone metabolism, RNA, Small Interfering metabolism, Signal Transduction physiology, Antigens, CD metabolism, Cell Membrane metabolism, Membrane Proteins metabolism, Receptor, Insulin metabolism, Receptors, Progesterone metabolism
- Abstract
The insulin receptor (IR) is a ligand-activated receptor tyrosine kinase that has a key role in metabolism, cellular survival, and proliferation. Progesterone receptor membrane component 1 (PGRMC1) promotes cellular signaling via receptor trafficking and is essential for some elements of tumor growth and metastasis. In the present study, we demonstrate that PGRMC1 coprecipitates with IR. Furthermore, we show that PGRMC1 increases plasma membrane IR levels in multiple cell lines and decreases insulin binding at the cell surface. The findings have therapeutic applications because a small-molecule PGRMC1 ligand, AG205, also decreases plasma membrane IR levels. However, PGRMC1 knockdown via short hairpin RNA expression and AG205 treatment potentiated insulin-mediated phosphorylation of the IR signaling mediator AKT. Finally, PGRMC1 also increased plasma membrane levels of two key glucose transporters, GLUT-4 and GLUT-1. Our data support a role for PGRMC1 maintaining plasma membrane pools of the receptor, modulating IR signaling and function., (Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics.)
- Published
- 2018
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26. Intravitreal Aflibercept for Neovascular Polypoidal Choroidal Vasculopathy in a Predominantly Non-Asian Population: RIVAL Results.
- Author
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Farooq A, Frazier H, Marcus WB, Fechter C, Singh H, and Marcus DM
- Subjects
- Aged, Aged, 80 and over, Choroid pathology, Choroidal Neovascularization diagnosis, Dose-Response Relationship, Drug, Female, Fluorescein Angiography, Follow-Up Studies, Fundus Oculi, Humans, Intravitreal Injections, Male, Middle Aged, Polyps diagnosis, Prospective Studies, Receptors, Vascular Endothelial Growth Factor antagonists & inhibitors, Time Factors, Tomography, Optical Coherence, Treatment Outcome, Visual Acuity, Choroid blood supply, Choroidal Neovascularization drug therapy, Polyps drug therapy, Receptors, Vascular Endothelial Growth Factor administration & dosage, Recombinant Fusion Proteins administration & dosage
- Abstract
Background and Objective: To evaluate safety and efficacy of intravitreal aflibercept (Eylea; Regeneron, Tarrytown, NY) injection (IAI) for the treatment of neovascular polypoidal choroidal vasculopathy (PCV) in a predominantly non-Asian population., Patients and Methods: This was an open-label, prospective, unmasked, nonrandomized clinical trial. Twenty eyes with neovascular PCV received monthly 2.0 mg IAI for 3 months followed by mandatory IAI every 2 months for 12 months., Results: The mean change in ETDRS best-corrected visual acuity from baseline to 1 year was +11 letters in the treatment-naïve group, +5 letters in the treatment non-naïve group, and +9 letters overall. There was an overall mean reduction of 70 µm from baseline central subfield thickness (CST) at 1 year. Patients received a mean of 6.2 mandatory and 0.7 additional IAI injections overall during the course of 1 year. No serious ocular adverse events were reported., Conclusion: At 1 year, neovascular PCV in a predominantly non-Asian population treated with IAI demonstrated favorable visual, anatomic, and safety outcomes. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:34-44.]., (Copyright 2017, SLACK Incorporated.)
- Published
- 2017
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27. Ranibizumab 0.3 mg for Persistent Diabetic Macular Edema After Recent, Frequent, and Chronic Bevacizumab: The ROTATE Trial.
- Author
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Fechter C, Frazier H, Marcus WB, Farooq A, Singh H, and Marcus DM
- Subjects
- Adult, Aged, Aged, 80 and over, Angiogenesis Inhibitors adverse effects, Angiogenesis Inhibitors therapeutic use, Bevacizumab therapeutic use, Female, Humans, Intravitreal Injections, Male, Middle Aged, Prospective Studies, Ranibizumab adverse effects, Tomography, Optical Coherence, Visual Acuity, Diabetic Retinopathy drug therapy, Macular Edema drug therapy, Ranibizumab therapeutic use
- Abstract
Background and Objective: To evaluate the safety and efficacy of 0.3 mg ranibizumab (Lucentis; Genentech, South San Francisco, CA) in eyes with persistent diabetic macular edema (DME) after recent, chronic, and frequent bevacizumab (Avastin; Genentech, South San Francisco, CA)., Patients and Methods: Open-label, prospective study of 0.3 mg ranibizumab for eyes with persistent DME after bevacizumab. Thirty eyes randomized to a sustained group or a pro re nata (PRN) dosing group., Results: The mean change in ETDRS best-corrected visual acuity from baseline to 1 year was +6.7 letters in the sustained group, +6.4 letters in the PRN group, and +6.5 letters overall. There was an overall mean reduction of 116 µm from baseline central subfield thickness at 1 year, with -92 µm and -127 µm decreases in the sustained and PRN groups, respectively. Adverse events included two deaths; one patient with multiple cardiopulmonary comorbidities, myocardial infarction, stroke, osteomyelitis; and mild posterior subcapsular cataracts in two eyes., Conclusion: Ranibizumab 0.3 mg demonstrated improved visual and anatomic outcomes in patients with persistent DME following bevacizumab. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:1030-1037.]., (Copyright 2016, SLACK Incorporated.)
- Published
- 2016
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28. Takotsubo stress-induced cardiomyopathy following robotic radical cystectomy.
- Author
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Gomella PT and Frazier H
- Subjects
- Aged, Fatal Outcome, Humans, Male, Takotsubo Cardiomyopathy diagnosis, Takotsubo Cardiomyopathy epidemiology, Cystectomy adverse effects, Postoperative Complications, Robotics, Stress, Psychological, Takotsubo Cardiomyopathy etiology, Urinary Bladder Neoplasms surgery
- Abstract
Cardiac complications following surgery can be devastating especially if it is unrecognized. We present a case of a stress-induced cardiomyopathy that occurred in postoperative period following a robotic radical cystectomy and urinary diversion. While most cases of stress-induced cardiomyopathy, also known as Takotsubo cardiomyopathy, are transient and with little to no long term clinical effects, a small number of patients can develop severe complications. This has not been reported in urologic literature and the unique characteristics of this cardiac condition are reviewed.
- Published
- 2016
29. Circulating Tumor Cells in Biochemical Recurrence of Prostate Cancer.
- Author
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Aragon-Ching JB, Siegel RS, Frazier H 2nd, Andrawis R, Hendricks F, Phillips M, Jarrett T, Guebre-Xabiher H, Patierno S, and Simmens SJ
- Subjects
- Aged, Aged, 80 and over, Humans, Male, Middle Aged, Neoplasm Grading, Neoplasm Metastasis, Prognosis, Prostatic Neoplasms blood, Prostatic Neoplasms pathology, Biomarkers, Tumor blood, Neoplastic Cells, Circulating pathology, Prostate-Specific Antigen blood, Prostatic Neoplasms radiotherapy, Prostatic Neoplasms surgery
- Abstract
Objective: Circulating tumor cells (CTCs) have known prognostic implications in metastatic castration-resistant prostate cancer, but little is known regarding its utility in biochemical recurrence (BR) of prostate cancer. The primary objectives were to determine whether CTCs are measurable in patients with BR and whether it can reliably predict prostate-specific antigen (PSA) increase and PSA doubling times (PSADTs)., Methods: BR was identified in patients after prostatectomy or radiation or both, with a PSA increase of ≥ 0.2 for prior prostatectomy or > 2 mg/dL increase for post-nadir in prior radiotherapy. CTCs were enumerated at baseline at the time of study entry using the CellSearch (Janssen Diagnostics, Raritan, NJ) test., Results: The median age for all 36 patients accrued was 69.5 years (range, 51-91) with a median PSA of 1.65 ng/mL (range, 0.2-65.8). Gleason scores ranged from 5 to 9 (median, 7). The majority had prostatectomy (n = 25), external beam radiotherapy (n = 9), CyberKnife (Accuray, Sunnyvale, CA) (n = 1), and combined radiohormonal therapy (n = 1). PSADT ranged from 0.35 to 55 months, with a median of 7.43 months. The incidence of positive CTCs was 8.3% (3 patients), of whom 2 had biopsy-proven bony lesions on presenting with equivocal scans and PSADTs of 2.27 and 3.08 months, respectively. The third CTC-positive patient had a PSADT of 4.99 months., Conclusions: Obtaining CTCs in unselected patients presenting with BR has a relatively low yield. However, obtaining a positive CTC raises the suspicion of the presence of metastatic disease and may have utility for longitudinal follow-ups of patients with BR., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
30. Androgen receptor-target genes in african american prostate cancer disparities.
- Author
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Wang BD, Yang Q, Ceniccola K, Bianco F, Andrawis R, Jarrett T, Frazier H, Patierno SR, and Lee NH
- Abstract
The incidence and mortality rates of prostate cancer (PCa) are higher in African American (AA) compared to Caucasian American (CA) men. To elucidate the molecular mechanisms underlying PCa disparities, we employed an integrative approach combining gene expression profiling and pathway and promoter analyses to investigate differential transcriptomes and deregulated signaling pathways in AA versus CA cancers. A comparison of AA and CA PCa specimens identified 1,188 differentially expressed genes. Interestingly, these transcriptional differences were overrepresented in signaling pathways that converged on the androgen receptor (AR), suggesting that the AR may be a unifying oncogenic theme in AA PCa. Gene promoter analysis revealed that 382 out of 1,188 genes contained cis-acting AR-binding sequences. Chromatin immunoprecipitation confirmed STAT1, RHOA, ITGB5, MAPKAPK2, CSNK2A,1 and PIK3CB genes as novel AR targets in PCa disparities. Moreover, functional screens revealed that androgen-stimulated AR binding and upregulation of RHOA, ITGB5, and PIK3CB genes were associated with increased invasive activity of AA PCa cells, as siRNA-mediated knockdown of each gene caused a loss of androgen-stimulated invasion. In summation, our findings demonstrate that transcriptional changes have preferentially occurred in multiple signaling pathways converging ("transcriptional convergence") on AR signaling, thereby contributing to AR-target gene activation and PCa aggressiveness in AAs.
- Published
- 2013
- Full Text
- View/download PDF
31. Surgical complications after robot-assisted laparoscopic radical prostatectomy: the initial 1000 cases stratified by the clavien classification system.
- Author
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Ahmed F, Rhee J, Sutherland D, Benjamin C, Engel J, and Frazier H 2nd
- Subjects
- Humans, Male, Middle Aged, Perioperative Care, Laparoscopy adverse effects, Postoperative Complications classification, Postoperative Complications etiology, Prostatectomy adverse effects, Prostatic Neoplasms surgery, Robotics
- Abstract
Background and Purpose: Complications after robot-assisted prostatectomy are widely reported and varied. Our goal was to determine the incidence of surgical complications resulting from robot-assisted laparoscopic radical prostatectomy (RALP) during the initial phase of a new robotics program that was developed by two surgeons without laparoscopic or robotic fellowship training. A secondary goal was to see if experience changed the incidence of complications with this technology., Patients and Methods: A prospectively maintained database was used to evaluate the first 1000 consecutive patients who were treated with RALP from January 2004 to June 2009. The database was reviewed for evidence of complications in the perioperative period. All patients underwent robot-assisted laparoscopic radical prostatectomy by two surgeons. Complications were confirmed and supplemented by retrospectively reviewing the departmental morbidity and mortality reports, as well as the hospital records. The Clavien classification system, a standardized and validated scale for complication reporting, was applied to all events. The complication rate was determined per 100 patients treated and tested with logistic regression for a relationship with surgeon experience., Results: Ninety-seven (9.7%) patients experienced a total of 116 complications; 81 patients experienced a single complication and 16 patients experienced ≥2 complications. The majority of complications (71%) were either grade I or II. The complication rate decreased with experience when the first 500 cases were compared with the latter 500 cases (P=0.007). All the data were reviewed retrospectively. Involvement of residents/fellows increased as primary surgeon experience improved., Conclusions: Complications after RALP are most commonly minor, requiring expectant or medical management only, even during the initiation of a RALP program. The complication rate improved significantly during the study period.
- Published
- 2012
- Full Text
- View/download PDF
32. A discussion of family-centered care within the pediatric intensive care unit.
- Author
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Frazier A, Frazier H, and Warren NA
- Subjects
- Adult, Child, Humans, Professional-Family Relations, Critical Care organization & administration, Family Nursing organization & administration, Intensive Care Units, Pediatric organization & administration
- Abstract
Every year, thousands of children are admitted to pediatric intensive care for treatment. Many of these admissions are for acute injuries, but children with chronic illnesses requiring repeated hospitalization are also on the rise. Hospitalization of a child is extremely stressful for both the patient and family. Historically, intensive care units had restrictive visitation hours and did not allow for sibling visitation or multiple family members. Parents and family members were not encouraged to participate in care when at the bedside. As the shift toward family-centered care continues, many hospitals are now changing visitation policies to allow for active family involvement in patient care. Parents are now encouraged to participate in care. Intensive care units are modifying layouts of the unit to facilitate visitors and provide sleeping spaces for parents when available. Families are considered part of the team instead of visitors, and are included in the decision making process. The purpose of this article is to promote discussion of family-centered care in the pediatric intensive care unit.
- Published
- 2010
- Full Text
- View/download PDF
33. Long-term follow-up of Thoratec ventricular assist device bridge-to-recovery patients successfully removed from support after recovery of ventricular function.
- Author
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Farrar DJ, Holman WR, McBride LR, Kormos RL, Icenogle TB, Hendry PJ, Moore CH, Loisance DY, El-Banayosy A, and Frazier H
- Subjects
- Adolescent, Adult, Child, Equipment Design, Female, Follow-Up Studies, Heart Diseases physiopathology, Humans, Male, Middle Aged, Recovery of Function, Time Factors, Heart Diseases therapy, Heart-Assist Devices, Ventricular Function physiology
- Abstract
Background: In certain forms of severe heart failure there is sufficient improvement in cardiac function during ventricular assist device (VAD) support to allow removal of the device. However, it is critical to know whether there is sustained recovery of the heart and long-term patient survival if VAD bridging to recovery is to be considered over the option of transplantation., Methods: To determine long-term outcome of survivors of VAD bridge-to-recovery procedures, we retrospectively evaluated 22 patients with non-ischemic heart failure successfully weaned from the Thoratec left ventricular assist device (LVAD) or biventricular assist device (BVAD) after recovery of ventricular function at 14 medical centers. All patients were in imminent risk of dying and were selected for VAD support using standard bridge-to-transplant requirements. There were 12 females and 10 males with an average age of 32 (range, 12-49). The etiologies were 12 with myocarditis, 7 with cardiomyopathies (4 post-partum [PPCM], 1 viral [VCM], and 2 idiopathic [IDCM]), and 3 with a combination of myocarditis and cardiomyopathy. BVADs were used in 13 patients and isolated LVADs in 9 patients, for an average duration of 57 days (range, 11-190 days), before return of ventricular function and successful weaning from the device. Post-VAD survival was compared with 43 VAD bridge-to-transplant patients with the same etiologies who underwent cardiac transplantation instead of device weaning., Results: Nineteen of the 22 patients are currently alive. Three patients required heart transplantation, 1 within 1 day, 2 at 12 and 13 months post-weaning, and 2 died at 2.5 and 6 months. The remaining 17 patients are alive with their native hearts after an average of 3.2 years (range, 1.2-10 years). The actuarial survival of native hearts (transplant-free survival) post-VAD support is 86% at 1 year and 77% at 5 years, which was not significantly different (p = 0.94) from that of post-VAD transplanted patients, also at 86% and 77%, respectively., Conclusions: Long-term survival for bridge-to-recovery with VADs for acute cardiomyopathies and myocarditis is equivalent to that for cardiac transplantation. Recovery of the native heart, which can take weeks to months of VAD support, is the most desirable clinical outcome and should be actively sought, with transplantation used only after recovery of ventricular function has been ruled out.
- Published
- 2002
- Full Text
- View/download PDF
34. Comparison of PRA-STAT, sHLA-EIA, and anti-human globulin-panel reactive antibody to identify alloreactivity in pretransplantation sera of heart transplant recipients: correlation to rejection and posttransplantation coronary artery disease.
- Author
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Kerman RH, Susskind B, Kerman D, Lam M, Gerolami K, Williams J, Kalish R, Campbell M, Katz S, Van Buren CT, Frazier H, Radovancevic B, Fife S, and Kahan B
- Subjects
- Antibody Specificity, Enzyme-Linked Immunosorbent Assay, Graft Survival, Histocompatibility Testing, Humans, Risk Factors, Coronary Disease etiology, Graft Rejection diagnosis, Heart Transplantation immunology, Histocompatibility Antigens Class I immunology, Isoantibodies blood, gamma-Globulins immunology
- Abstract
Background: Screening pretransplantation recipient sera for percent panel reactive antibodies (%PRA) by an anti-human globulin (AHG) assay may identify recipients who are at risk for graft rejection or development of posttransplantation coronary artery disease. However, the pretransplantation AHG-%PRA does not always correlate with the occurrence of graft rejection or coronary artery disease., Methods: We compared the predictive capacity of the AHG-%PRA with that of an enzyme-linked immunoassay (EIA)-based PRA assay that identifies immunoglobulin G bound to soluble human leukocyte antigen (sHLA) class I molecules from pooled platelets of 240 random donors (sHLA-EIA), and that of an EIA-based assay that detects immunoglobulin G anti-HLA class I antibodies bound to sHLA derived from individual HLA-typed cell cultures (PRA-STAT). The pretransplantation sera from 130 cardiac allograft recipients were comparatively tested and results evaluated., Results: Although AHG-%PRA- and sHLA-EIA-determined PRA results were comparable, neither assay discriminated potential recipients at risk for rejection or coronary artery disease. However, cardiac allograft recipients with pretransplantation PRA-STAT sera > 10% were at risk for (1) graft rejection (77% vs 56%, p < .05); (2) more rejections/recipient (1.9 vs 1.0, p < .02); (3) graft rejection within 30 days (92% vs 38%, p < .001); or (4) development of coronary artery disease (48% vs 23%, p < .05) than recipients with pretransplantation PRA-STAT sera < 10%., Conclusions: PRA-STAT analysis of pretransplantation sera from potential cardiac allograft recipients may be more clinically informative about HLA alloimmunity and a better predictor of adverse clinical events than either AHG-%PRA- or sHLA-EIA-determined PRA.
- Published
- 1998
35. Transitional cell carcinoma of the kidney with tumor thrombus into the vena cava.
- Author
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Williams JH, Frazier HA 2nd, Gawith KE, Laskin WB, and Christenson PJ
- Subjects
- Aged, Humans, Male, Carcinoma, Transitional Cell secondary, Kidney Neoplasms pathology, Neoplastic Cells, Circulating, Vena Cava, Inferior
- Abstract
Transitional cell carcinoma of the upper urinary tract with inferior vena cava tumor thrombus is an unusual entity. We report the 16th such case and review the previous cases in the world literature. Preoperative diagnosis was correct in only 5 of the cases. This type of condition can be easily presumed to be renal cell carcinoma. Fifteen of the cases were managed with radical nephrectomy; 8 patients were managed with partial or complete resection of the vena cava due to adherence of the tumor thrombus to the vessel wall. Overall outcome was poor, with short postoperative survival. Correct preoperative diagnosis, although difficult, could allow more complete preoperative planning or appropriate nonoperative management.
- Published
- 1996
- Full Text
- View/download PDF
36. Germ cell testis cancer: 15-year review.
- Author
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Kelty P, Frazier H, O'Connell K, and Ghosh BC
- Subjects
- Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Combined Modality Therapy, Follow-Up Studies, Germinoma mortality, Humans, Lymph Node Excision, Male, Orchiectomy, Prognosis, Radiotherapy, Adjuvant, Retrospective Studies, Survival Rate, Testicular Neoplasms mortality, Germinoma therapy, Testicular Neoplasms therapy
- Abstract
Testis cancer affects 2-3 men per every 100,000 in the United States, making it the most common solid tumor of men in the 20-35-year-old age range. Since the average age of active duty military personnel is included in the age range of those at greatest risk for germ cell testis cancer, it is of pertinent clinical importance to physicians who treat these young patients. The National Naval Medical Center has been using cisplatin-based protocols since the time of their introduction. This study reviews the success of treating these patients and examines the treatment failures.
- Published
- 1996
- Full Text
- View/download PDF
37. Diagnosis, surveillance, and epidemiologic evaluation of viral infections in pediatric cardiac transplant recipients with the use of the polymerase chain reaction.
- Author
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Schowengerdt KO, Ni J, Denfield SW, Gajarski RJ, Radovancevic B, Frazier HO, Demmler GJ, Kearney D, Bricker JT, and Towbin JA
- Subjects
- Adenoviruses, Human genetics, Adolescent, Adult, Base Sequence genetics, Biopsy, Child, Child, Preschool, Cytomegalovirus genetics, Cytomegalovirus Infections immunology, Cytomegalovirus Infections pathology, Cytomegalovirus Infections transmission, DNA, Viral genetics, Diagnosis, Differential, Drug Therapy, Combination, Endocardium immunology, Endocardium pathology, Enterovirus genetics, Female, Graft Rejection diagnosis, Graft Rejection immunology, Graft Rejection pathology, Heart Transplantation pathology, Heart Ventricles immunology, Heart Ventricles pathology, Herpesvirus 4, Human genetics, Humans, Immunosuppressive Agents adverse effects, Immunosuppressive Agents therapeutic use, Infant, Male, Molecular Sequence Data, Myocardium immunology, Myocardium pathology, Opportunistic Infections immunology, Opportunistic Infections pathology, Opportunistic Infections transmission, Parvovirus genetics, Risk Factors, Simplexvirus genetics, Tissue Donors, Virus Diseases immunology, Virus Diseases pathology, Virus Diseases transmission, Cytomegalovirus Infections diagnosis, Heart Transplantation immunology, Opportunistic Infections diagnosis, Polymerase Chain Reaction, Virus Diseases diagnosis
- Abstract
Background: Viral infections, particularly those caused by cytomegalovirus, are a major cause of postoperative morbidity and mortality in heart transplant recipients. These infections have classically been diagnosed by history, physical examination, peripheral viral cultures, and serologic studies. These methods are often time-consuming and lack sensitivity. Positive viral cultures from the heart are rarely obtained, and viral myocarditis and acute cellular rejection are unable to be differentiated histologically. We have therefore used the polymerse chain reaction to diagnose possible viral infection in pediatric heart transplant recipients with findings consistent with acute unexplained rejection., Methods: Polymerase chain reaction was used as an aid to diagnose cytomegalovirus infection of cardiac tissue obtained by right ventricular endomyocardial biopsy and follow its long-term course. In addition, polymerase chain reaction was used to diagnose infection of the heart by other viruses in patients with clinical and histologic evidence of rejection, especially those with unexplained late rejection or chronic rejection. Polymerase chain reaction primers were designed to amplify nucleic acid sequences from cytomegalovirus, parvovirus, adenovirus, herpes simplex virus, Epstein-Barr virus, and the RNA viruses of the Enterovirus family., Results: Forty patients underwent serial right ventricular endomyocardial biopsy (129 samples) for rejection surveillance with positive results obtained in 41 samples (32%) from 21 patients. Viral genome amplified included cytomegalovirus in 16 samples, adenovirus in 14, enterovirus in 6, parvovirus in 3, and herpes simplex virus in 2. In 13 of the 21 patients positive for viral genome (62%), endomyocardial biopsy histologic scores were consistent with multifocal moderate to severe rejection (Internal Society for Heart and Lung Transplantation scores of 3A or greater)., Conclusions: Polymerase chain reactions may be used as a rapid and sensitive method to evaluate postoperative viral infections in heart transplant recipients, especially in those with late-onset rejection or chronic rejection. Polymerase chain reaction may also be useful in the serial analysis of cytomegalovirus status in transplant recipients. The use of multiple viral primers improves the diagnostic evaluation of these patients and may lead to a better understanding of the epidemiologic characteristics of posttransplantation viral infections and the cause of late or chronic rejection.
- Published
- 1996
38. Relationships of patient satisfaction with experience of system performance and health status.
- Author
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Zapka JG, Palmer RH, Hargraves JL, Nerenz D, Frazier HS, and Warner CK
- Subjects
- Adult, Aged, Ambulatory Care standards, Female, Health Maintenance Organizations organization & administration, Humans, Male, Middle Aged, Surveys and Questionnaires, United States, Health Maintenance Organizations standards, Health Status, Patient Satisfaction statistics & numerical data, Process Assessment, Health Care
- Abstract
This article investigates the relationship between three types of measures obtained from consumer surveys: satisfaction, health status, and report of systems performance. Analyses demonstrate that patient reports of the quality of processes of care or system performance (such as receiving results of tests or receiving conflicting information from staff members) are significantly related to satisfaction independently of perception of health status. Since dissatisfaction is known to be associated with disenrollment, patient reports of system performance are of great interest to health plans.
- Published
- 1995
- Full Text
- View/download PDF
39. Correspondence Re: Abraham NZ, Maher TJ, Hutchison RE: Extra-nodal monocytoid B-cell lymphoma of the urinary bladder. Mod Pathol 6:145, 1993.
- Author
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Summers DE, Berlot JL, Frame JN, Gray JR, Frazier HA, and Cotelingam JD
- Subjects
- Female, Humans, Middle Aged, Lymphoma, B-Cell pathology, Urinary Bladder Neoplasms pathology
- Published
- 1994
40. Does of stage pT0 cystectomy specimen confer a survival advantage in patients with minimally invasive bladder cancer?
- Author
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Thrasher JB, Frazier HA, Robertson JE, and Paulson DF
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Transitional Cell surgery, Cystectomy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Retrospective Studies, Survival Rate, Treatment Outcome, Urinary Bladder Neoplasms surgery, Carcinoma, Transitional Cell mortality, Carcinoma, Transitional Cell pathology, Urinary Bladder Neoplasms mortality, Urinary Bladder Neoplasms pathology
- Abstract
Controversy exists regarding the clinical significance of a pathological stage T0 (pT0) specimen found at cystectomy or after repeat transurethral resection for transitional cell carcinoma of the bladder. Many investigators cite this subpopulation of patients as a reason to consider more conservative management, based on the premise that the patient may have benefited from the original transurethral resection. However, we questioned whether outcome would be improved in stage pT0 cancer patients or whether outcome in stage pT0 cases would parallel that noted when the original stage was equivalent to the final pathological stage. To test this hypothesis, we examined the survival advantage occasioned by a stage pT0 finding in 66 of 433 patients who underwent radical cystectomy for transitional cell carcinoma of the bladder. Of the 433 patients studied 54 had clinical stage Tis or Ta, 166 clinical stage T1 and 213 clinical stage T2 disease. Within each of the 3 clinical groups (clinical stage Tis/Ta, clinical stage T1 and clinical stage T2) Kaplan-Meier survival projections were generated comparing patients with stage pT0 disease to those whose pathological stage was identical to the original clinical stage. Among the 54 clinical stage Tis/Ta cancer patients 11 with stage pT0 and 24 with stage pTis/pTa had survival projections of 90% of 5 years. Of 166 patients with clinical stage T1 disease 32 with stage pT0 and 78 with stage pT1 tumor had survival projections of 75% at 5 years. Among 213 patients with clinical stage T2 cancer 23 with stage pT0 and 71 with stage pT2 disease had survival projections of 68% at 5 years. The data suggest that a stage pT0 cystectomy specimen does not confer a survival advantage over that noted from the initiating population in which the final pathological stage and initial clinical stage are equivalent. A patient with a stage pT0 specimen functions, by survival analysis, in a manner similar to one with the stated clinical stage.
- Published
- 1994
- Full Text
- View/download PDF
41. Transvalvular left ventricular assistance in cardiogenic shock secondary to acute myocardial infarction. Evidence for recovery from near fatal myocardial stunning.
- Author
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Smalling RW, Sweeney M, Lachterman B, Hess MJ, Morris R, Anderson HV, Heibig J, Li G, Willerson JT, and Frazier H
- Subjects
- Female, Humans, Male, Middle Aged, Myocardial Infarction mortality, Myocardial Stunning physiopathology, Pilot Projects, Shock, Cardiogenic etiology, Shock, Cardiogenic mortality, Survival Rate, Time Factors, Heart-Assist Devices, Hemodynamics physiology, Myocardial Infarction complications, Myocardial Stunning therapy, Shock, Cardiogenic therapy
- Abstract
Objectives: The purpose of this study was to test the hypothesis that transvalvular left ventricular assistance would support the circulation in patients with cardiogenic shock secondary to acute myocardial infarction and allow recovery of function in patients with a reversibly damaged (stunned) left ventricle., Background: Cardiogenic shock occurs in 7.5% of patients presenting with acute myocardial infarction, resulting in survival of only 20%. Despite the use of aggressive interventional therapy in patients with shock secondary to anterior myocardial infarction, survival remains as low as 33%., Methods: We studied 11 patients with acute myocardial infarction and cardiogenic shock, as defined by a cardiac index < 2 liters/min per m2, pulmonary capillary wedge pressure > 18 mm Hg and systolic blood pressure < 90 mm Hg during positive inotropic therapy. Patients were 57 +/- 13 years old (mean +/- SD) and had a mean left ventricular ejection fraction of 25 +/- 11%, mean arterial pressure of 69 +/- 13 mm Hg and mean cardiac index of 1.6 +/- 0.4 liters/min per m2 on admission to the study., Results: During the 1st 24 h of left ventricular assistance, pulmonary capillary wedge pressure decreased from 26 +/- 4 to 16 +/- 4 mm Hg (p = 0.01), cardiac index increased from 1.6 +/- 0.4 to 2.4 +/- 0.4 liters/min per m2, and the dopamine hydrochloride dose decreased from 51 +/- 92 to 18 +/- 12 micrograms/kg body weight per min. In survivors, cardiac index improved to 3.2 +/- 0.5 liters/min per m2 (p = 0.01), and left ventricular ejection fraction improved to 34 +/- 5% (p < 0.05). The overall survival in the study group was 4 (36%) of 11 patients (95% confidence interval [CI] 8% to 65%), and 4 (66%) of 6 patients (95% CI 29% to 100%) with a Q wave anterior myocardial infarction survived., Conclusions: Transvalvular left ventricular support during cardiogenic shock complicating acute myocardial infarction is feasible and results in significant hemodynamic and functional improvement.
- Published
- 1994
- Full Text
- View/download PDF
42. Radical cystectomy for stages Ta, Tis and T1 transitional cell carcinoma of the bladder.
- Author
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Amling CL, Thrasher JB, Frazier HA, Dodge RK, Robertson JE, and Paulson DF
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Transitional Cell epidemiology, Carcinoma, Transitional Cell pathology, Female, Follow-Up Studies, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Pelvis, Postoperative Complications epidemiology, Survival Rate, Urinary Bladder Neoplasms epidemiology, Urinary Bladder Neoplasms pathology, Carcinoma, Transitional Cell surgery, Cystectomy methods, Neoplasm Recurrence, Local epidemiology, Urinary Bladder Neoplasms surgery
- Abstract
Between January 1969 and January 1990, 531 patients underwent bilateral pelvic lymph node dissection and radical cystectomy for the management of transitional cell carcinoma of the bladder. Of these procedures 220 were performed for clinical stage Ta (31 patients), Tis (23) or T1 (166) disease, which was either high grade or recalcitrant to transurethral resection and/or intravesical chemotherapy. This subgroup of patients was studied to evaluate the outcome of recurrent or chemotherapy resistant superficial transitional cell carcinoma of the bladder after radical cystectomy. The operative mortality rate for the group was 2.3% and the overall complication rate was 20.4%. The pelvic recurrence rate was 5.9%. The 5-year cancer-specific survival rates for patients with pathological stage Ta (11), Tis (19), T0 (43) and T1 (91) disease were 88%, 100%, 80% and 76%, respectively. The 10-year cancer-specific survival rates were 75%, 92%, 66% and 62%, respectively. A total of 74 patients received preoperative radiation therapy (2,000 rad) but they had no better 5-year cancer-specific survival rates than did nonirradiated patients. Transurethral resection and/or preoperative radiation therapy resulted in a pathological status of T0 in 43 patients but this did not confer a survival advantage. Although bladder preservation is preferable, low operative mortality and pelvic recurrence rates, as well as new methods of continent urinary diversion continue to make radical cystectomy the definitive form of therapy for patients with superficial disease recalcitrant to transurethral therapy.
- Published
- 1994
- Full Text
- View/download PDF
43. Improving health: measuring effects of medical care.
- Author
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Bunker JP, Frazier HS, and Mosteller F
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Cause of Death, Child, Child, Preschool, Clinical Medicine, Female, Health Status, Humans, Immunization trends, Life Style, Male, Mass Screening trends, Middle Aged, Preventive Medicine, Survival Analysis, United States, Health Services Research methods, Life Expectancy, Quality of Life, Treatment Outcome
- Abstract
The impact of medical care on the quality and length of life of the population has been poorly documented. The rapid growth of evidence of efficacy of therapy for individual medical conditions now offers the opportunity to create an inventory of benefits. A method for creating such an inventory is described, as is its application to a selection of condition-treatment pairs, chosen for their high incidence of prevalence, their serious outcomes, and the demonstrated efficacy of their treatment. An aggregate effect of medical care on life expectancy is found to be roughly five years during this century, with a further potential of two years. Although there is no overall index of quality of life analogous to life expectancy, our inventory demonstrates the enormous burden of pain, suffering, and dysfunction that afflicts the population for which medical care can provide a large measure of relief.
- Published
- 1994
44. Using patient reports to measure health care system performance.
- Author
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Hargraves JL, Palmer RH, Zapka J, Nerenz D, Frazier H, Orav EJ, Warner C, Ingard J, and Neisuler R
- Subjects
- Algorithms, Chronic Disease, Continuity of Patient Care, Female, Health Services Accessibility, Humans, Interprofessional Relations, Male, Management Audit methods, Medical Audit methods, Self-Assessment, United States, Patient Satisfaction statistics & numerical data, Process Assessment, Health Care statistics & numerical data, Surveys and Questionnaires
- Abstract
We developed a self-administered patient questionnaire that asks for data concerning the time to receive services (access to care), communication between providers (coordination of care), and follow up after tests and treatment (continuity of care). From these data, we construct rates of performance about the clinical management systems that support provision of these services. Rates of system performance are calculated for indicators using patients' responses to survey questions. These indicators add the number of patients reporting a problem of those patients who have encountered a particular clinical management system. Information derived from 3000 patient questionnaires is matched with data abstracted from health care medical records. The sensitivity and specificity of patient reports are being evaluated for all indicators classified as gold standards for medical records. Indicators considered gold standard items for patient reports are matched for agreement with any information contained in the medical record. Also, patient characteristics associated with accurate reporting is to be assessed using multivariate logistic regression models.
- Published
- 1993
45. Is prostate specific antigen of clinical importance in evaluating outcome after radical prostatectomy.
- Author
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Frazier HA, Robertson JE, Humphrey PA, and Paulson DF
- Subjects
- Adult, Aged, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Period, Preoperative Care, Prostatic Neoplasms surgery, Retrospective Studies, Treatment Failure, Prostate-Specific Antigen blood, Prostatectomy methods, Prostatic Neoplasms blood
- Abstract
Current bias would conclude that elevation of serum prostate specific antigen (PSA) after radical prostatectomy infers failure of the procedure. Since April 1987 preoperative and postoperative serum PSA levels have been obtained on 226 patients who underwent radical perineal prostatectomy for presumed organ confined prostate cancer (stage T1-2N0M0). Clinical failure as defined by elevation of serum acid phosphatase, biopsy proved local recurrence or evidence of malignant disease on bone scan has occurred in 3.9% of the patients with organ confined, 7.0% with specimen confined and 13.2% with margin positive disease. However, when a PSA elevation of greater than 0.5 ng./ml. was used as an indicator of failure the failure rate became 9.8% for the organ confined group, 39.4% for the specimen confined group and 66.0% for margin positive group. Of the patients who failed clinically the interval from initial elevation of postoperative PSA to clinical detection of failure ranged from 2 to 28 months (median 16). Among the patients with an elevated postoperative PSA level but who have not clinically failed followup ranged from 4 to 46 months (median 23). A total of 11 patients had no evidence of failure at greater than 36 months despite the elevated postoperative serum PSA level. These PSA elevations in patients who undergo supposed curative therapy are distressing. However, at this time the majority of these patients have not failed. In the clinically cured patient biochemical evidence of failure may not be sufficient to change the treatment course.
- Published
- 1993
- Full Text
- View/download PDF
46. Complications of radical cystectomy and urinary diversion: a retrospective review of 675 cases in 2 decades.
- Author
-
Frazier HA, Robertson JE, and Paulson DF
- Subjects
- Female, Humans, Male, Middle Aged, Retrospective Studies, Time Factors, Cystectomy adverse effects, Urinary Diversion adverse effects
- Abstract
A retrospective review was performed on all 675 patients who underwent radical cystectomy and urinary diversion during 2 decades. Of the patients 197 were treated from 1969 to 1979 (group 1) and 478 were treated from 1980 until 1990 (group 2). The mean age of patients in group 1 was 56.7 years versus 64.2 years in group 2 (p < 0.001). The overall operative mortality rate in both groups was 2.5%. A total of 215 patients (31.9%) experienced postoperative complications (within 30 days of surgery). The morbidity rate was nearly identical between the 2 groups (32.0% for group 1 versus 31.8% for group 2, p = 0.962). Of note, however, there was a decreased incidence of wound infections and wound dehiscence among the patients in group 2 compared to group 1. Long-term complications occurred in 198 of the 675 patients (29.3%). At followup group 1 had a 35.5% incidence of long-term complications versus 26.8% in group 2 (p = 0.022). Most notably there was significant improvement in the incidence of ureteroenteric anastomotic strictures when comparing groups 1 (11.2%) and 2 (5.2%) (p = 0.006).
- Published
- 1992
- Full Text
- View/download PDF
47. Total prostatoseminal vesiculectomy in the treatment of debilitating perineal pain.
- Author
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Frazier HA, Spalding TH, and Paulson DF
- Subjects
- Adult, Aged, Humans, Male, Middle Aged, Postoperative Complications, Pain, Intractable surgery, Perineum, Prostatectomy, Seminal Vesicles surgery
- Abstract
Persistent perineal pain, unresponsive to antibiotics and analgesia, sufficient to produce an inability to function in any work or social environment is occasionally encountered. A total of 5 such patients underwent total prostatoseminal vesiculectomy: 3 experienced complete relief of the pain and 1 experienced symptomatic relief to the extent that he ranks the residual discomfort as 1 on a scale of 1 to 10. The remaining patient had complete absence of pain for approximately 4 months but thereafter mild, intermittent proximal urethral discomfort developed during voiding. Total prostatoseminal vesiculectomy may be occasionally applicable in the patient disabled by chronic perineal pain. We believe that psychiatric evaluation and concurrence should be a preoperative prerequisite.
- Published
- 1992
- Full Text
- View/download PDF
48. Radical prostatectomy: the pros and cons of the perineal versus retropubic approach.
- Author
-
Frazier HA, Robertson JE, and Paulson DF
- Subjects
- Adult, Aged, Humans, Male, Middle Aged, Perineum, Prostatectomy adverse effects, Retrospective Studies, Time Factors, Prostatectomy methods, Prostatic Neoplasms surgery
- Abstract
Radical prostatectomy is frequently recommended for the treatment of localized adenocarcinoma of the prostate. The use of the perineal versus the retropubic approach is mostly dependent upon the experience of the individual surgeon. This study was performed to evaluate the short-term differences between the 2 operations. Between 1988 and 1989, 173 patients were identified with organ confined prostate cancer (stage A or B) who were treated with radical prostatectomy. Of this total population 122 patients underwent radical perineal prostatectomy (group 1) and 51 patients underwent radical retropubic prostatectomy (group 2). The median estimated blood loss for group 1 was 565 cc and for group 2 it was 2,000 cc (p less than 0.001). Group 1 received a median of 0 units of blood during hospitalization, while group 2 received a median of 3 units of blood (p less than 0.001). The total operative time was slightly shorter for group 1 but the anesthesia time was similar for both patient populations. There was no difference in the incidence of positive surgical margins, and in in-hospital and long-term complication rates between the 2 groups. In light of these significant findings it is our belief that the radical perineal prostatectomy is an excellent approach for the treatment of adenocarcinoma of the prostate.
- Published
- 1992
- Full Text
- View/download PDF
49. The detection of a patent urachus and allantoic cyst of the umbilical cord on prenatal ultrasonography.
- Author
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Frazier HA, Guerrieri JP, Thomas RL, and Christenson PJ
- Subjects
- Female, Humans, Pregnancy, Allantois diagnostic imaging, Fetal Diseases diagnostic imaging, Ultrasonography, Prenatal, Urachal Cyst diagnostic imaging, Urachus diagnostic imaging
- Published
- 1992
- Full Text
- View/download PDF
50. Immunoreactive prostatic specific antigen in male periurethral glands.
- Author
-
Frazier HA, Humphrey PA, Burchette JL, and Paulson DF
- Subjects
- Acid Phosphatase analysis, Antigens, Neoplasm immunology, Exocrine Glands enzymology, Humans, Immunohistochemistry, Male, Prostate enzymology, Prostate-Specific Antigen, Urethra enzymology, Antigens, Neoplasm analysis, Exocrine Glands immunology, Urethra immunology
- Abstract
Prostatic specific antigen (PSA) is considered an antigen unique to benign and malignant prostatic tissue. Recent evidence in the literature has raised serious doubts about the specificity of this antigen. In this study twenty male urethral specimens were evaluated for PSA and prostatic acid phosphatase (PAP) from patients without evidence of prostatic cancer. Eight of these 20 urethral specimens exhibited strong immunostaining for both PSA and PAP, localized in the periurethral glands. Five of the 17 urethral biopsies were positive for both antigens, while all three of the whole mount autopsy specimens stained positive for PSA and PAP. Within the autopsy series, there was heterogenous staining of the periurethral glands within the same specimen. This evidence disproves the fact that PSA and PAP are organ specific as previously described. More than likely any tissue of cloacal origin has potential for staining positive for prostatic specific antigen and prostatic acid phosphatase.
- Published
- 1992
- Full Text
- View/download PDF
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