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5 results on '"Fraser A. Marshall"'

3. Studies in the history and epigraphy of Hellenistic Rhodes

Author

Fraser, Peter Marshall, Tod, M. N., Balsdon, J. P. V. D., and Last, H. M.

Subjects
949.5, Rhodes (Greece, Island)--History, Rhodes, Epigraphic, Hellenistic
Abstract

The work is not a full-scale history of Rhodes in the Hellenistic age, the materials for which do not exist. It is rather an analysis of the ancient literary tradition regarding Hellenistic Rhodes on the one hand, and on the other an attempt to analyse, classify and exploit the very large body of epigraphical evidence in so far as it relates to the external aspects of Rhodian life. The results of this scrutiny of the epigraphical basis, here undertaken on a far wider basis than has ever before been possible, are as disappointing as conclusions based solely on epigraphical evidence are apt to be. The first half of the work examines in detail the tradition regarding the political history of Rhodes from 408/7 B.C., the year of the foundation of the city, to 164 B.C., the year in which Rhodes concluded an alliance with Rome, and thereby lost, largely in not wholly, the freedom of action which she had until then retained.

Published
1951

4. On the hunt for helminths: Innate immune cells in the recognition and response to helminth parasites

Author

Fraser A. Marshall, David Artis, and Jacqueline G. Perrigoue

Subjects
Stromal cell, Helminth protein, Immunology, Helminthiasis, Chitin, Biology, Microbiology, Article, Host-Parasite Interactions, Th2 Cells, Immunity, Virology, Helminths, Lectins, parasitic diseases, Animals, Humans, Innate immune system, Innate lymphoid cell, Toll-Like Receptors, CCL18, Interleukin, Helminth Proteins, Acquired immune system, Immunity, Innate, Peptide Hydrolases
Abstract

The generation of protective immunity to helminth parasites is critically dependent upon the development of a CD4 T helper type 2 cytokine response. However, the host-parasite interactions responsible for initiating this response are poorly understood. This review will discuss recent advances in our understanding of how helminth-derived products are recognized by innate immune cells. Specifically, interactions between helminth excretory/secretory products and host Toll-like receptors and lectins will be discussed as well as the putative functions of helminth proteases and chitin in activating and recruiting innate immune cells. In addition, the functional significance of pattern recognition by epithelial cells, granulocytes, dendritic cells, and macrophages including expression of alarmins, thymic stromal lymphopoetin (TSLP), interleukin (IL)-25, IL-33, and Notch ligands in the development of adaptive anti-parasite Th2 cytokine responses and the future research challenges in this area will be examined.

Published
2008

5. In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype

Author

Fraser A. Marshall, Margaret M. Harnett, Emma H. Wilson, Helen S. Goodridge, William Harnett, Katrina M. Houston, and Foo Y. Liew

Subjects
Lipopolysaccharides, Male, Cellular differentiation, Phosphorylcholine, Immunology, Priming (immunology), Biology, Host-Parasite Interactions, Mice, Immune system, In vivo, Helminths, medicine, Immune Tolerance, Immunology and Allergy, Animals, Humans, Cells, Cultured, Myeloid Progenitor Cells, Inflammation, Mice, Inbred BALB C, Macrophages, Cell Differentiation, Dendritic cell, Dendritic Cells, Helminth Proteins, Infusion Pumps, Implantable, Original Articles, Cell biology, medicine.anatomical_structure, Commentary, Cytokines, Bone marrow, Ex vivo
Abstract

We have previously shown in an in vitro study that the filarial nematode phosphorylcholine (PC)-containing glycoprotein ES-62 promotes a murine dendritic cell (DC) phenotype that induces T helper type 2 (Th2) responses. We now show that, in addition to directly priming Th2 responses, ES-62 can act to dampen down the pro-inflammatory DC responses elicited by lipopolysaccharide. Furthermore, we also demonstrate that murine DCs and macrophages derived ex vivo from bone marrow cells exposed in vivo to ES-62 by release from osmotic pumps are hyporesponsive to subsequent stimulation with lipopolysaccharide. These effects can be largely mimicked by exposure to the PC moiety of ES-62 conjugated to an irrelevant protein. The data we provide are, as far as we aware, the first to show that a defined pathogen product can modulate the developmental pathway of bone marrow cells of the immune system in vivo. Such a finding could have important implications for the use of pathogen products or their derivatives for immunotherapy.

Published
2004

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