87 results on '"Fracchiolla F"'
Search Results
2. Dosimetric and NTCP advantages of robust proton therapy over robust VMAT for Stage III NSCLC in the immunotherapy era
- Author
-
Dionisi, F., Landoni, V., Widesott, L., Nardangeli, A., Fracchiolla, F., Siniscalchi, B., Soriani, A., Turkaj, A., Righetto, R., Amelio, D., Farace, P., Goanta, L., Trianni, A., Lorentini, S., Cianchetti, M., and Sanguineti, G.
- Published
- 2024
- Full Text
- View/download PDF
3. Proton therapy treatment monitoring with in-beam PET: Investigating space and time activity distributions
- Author
-
Brombal, L., Barbosa, D., Belcari, N., Bisogni, M.G., Camarlinghi, N., Cristoforetti, L., Guerra, A. Del, Fracchiolla, F., Morrocchi, M., Sportelli, G., Righetto, R., Schwarz, M., Topi, A., and Rosso, V.
- Published
- 2017
- Full Text
- View/download PDF
4. MO-04.8 - INFLUENCE OF THE 4D ROBUST PLANNING APPROACH ON THE COMPARISON BETWEEN PHOTON AND PROTON FOR THE TREATMENT OF STAGE III LUNG CANCER: A DOSIMETRIC AND RADIOBIOLOGICAL STUDY
- Author
-
Widesott, L., Landoni, V., Dionisi, F., Siniscalchi, B., Nardangeli, A., Fracchiolla, F., Turkaj, A., Soriani, A., Righetto, R., Goanta, L., Farace, P., Petrongari, M.G., Trianni, A., Amelio, D., Lorentini, S., Cianchetti, M., and Sanguineti, G.
- Published
- 2023
- Full Text
- View/download PDF
5. CO-07.4 - REALISTIC ROBUSTNESS EVALUATION TOOL TO IMPROVE THE RELIABILITY OF MFO PROTON THERAPY PLAN EVALUATIONS IN SKULL BASE PATIENTS
- Author
-
Fracchiolla, F., Lorentini, S., Widesott, L., Amelio, D., Cianchetti, M., Rombi, B., and Trianni, A.
- Published
- 2023
- Full Text
- View/download PDF
6. Hippocampal Sparing Radiotherapy in adults with Primary Brain Tumors: A comparative planning and dosimetric study using IMPT, IMRT and 3DCRT
- Author
-
Aka, P, Taylor, R, Hugtenburg, R, Lambert, J, Powell, J, Bevolo, T, Gao, M, Gondi, V, Hartsell, W.H, Bolsi, A, Beer, J, Belosi, M.F, Siewert, D, Lomax, A.J, Weber, D.C, Huang, Y.J, Huang, C.C, Chao, P.J, Liu, C, Shang, H, Ding, X, Wang, Y, Mammar, H, Froelich, Sébastien, Alapetite, Claire, Bolle, Stéphanie, Calugaru, Valentin, Feuvret, Loic, Helfre, Sylvie, Champion, Laurence, Goudjil, Farid, Dendal, Remi, Engelholm, S.A, Munck Af Rosenschold, P, Kristensen, I, Smulders, B, Muhic, A, Alkner, S, Jacob, E, Engelholm, S, Aljabab, S, Lui, A, Wong, T, Liao, J, Laramore, G, Parvathaneni, U, Kharouta, M, Pidikiti, R, Jesseph, F, Smith, M, Dobbins, D, Mattson, D, Choi, S, Mansur, D, Machtay, M, Bhatt, A, Lütgendorf-Caucig, C, Dunavölgyi, R, Georg, P, Perpar, A, Fussl, C, Konstantinovic, R, Ulrike, M, Piero, F, Eugen, H, Vidal, M, Gerard, A, Barnel, C, Maneval, D, Herault, J, Claren, A, Doyen, J, Dendale, R, Toutee, A, Pasquie, I, Goudjil, F, Lumbroso Lerouic, L, Levy, C, Desjardins, L, Cassoux, N, Elisei, G, Pella, A, Calvi, G, Ricotti, R, Tagaste, B, Valvo, F, Ciocca, M, Via, R, Mastella, E, Baroni, G, Saotome, N, Yonai, S, Makishima, H, Hara, Y, Inaniwa, T, Sakama, M, Kanematsu, N, Tsuji, H, Furukawa, T, Shirai, T, Sauerwein, W, Finger, P.T, Gallie, B, Gavrylyuk, Y, Thariat, J, Salleron, J, Maschi, C, Fevrier, E, Caujolle, J.P, Hofverberg, P, Angellier, G, Peyrichon, M.L, Breneman, J, Esslinger, H, Pater, L, Vatner, R, Habrand, J.L, Stefan, D, Lesueur, P, Kao, W, Véla, A, Geffrelot, J, Tessonnier, T, Balosso, J, Mahé, M.A, Lim, P.S, Rompokos, V, Chang, Y.C, Royle, G, Gaze, M, Gains, J, Vennarini, S, Francesco, F, Rombi, B, Amichetti, M, Schwarz, M, Lorentini, S, Mee, T, Burnet, N.G, Crellin, A, Kirkby, N.F, Smith, E, Kirkby, K.J, Roggio, M, Buwenge, M, Melchionda, F, Ammendolia, I, Ronchi, L, Cammelli, S, Morganti, A.G, Youn, S.H, Kim, J.Y, Park, H.J, Shin, S.H, Lee, S.H, Hong, E.K, Czerska, K, Winczura, P, Wejs-Maternik, J, Blukis, A, Antonowicz-Szydlowska, M, Rucinski, A, Olko, P, Badzio, A, Kopec, R, Franceschini, D, Cozzi, L, De Rose, F, Meattini, I, Fogliata, A, Cozzi, S, Becherini, C, Tomatis, S, Livi, L, Scorsetti, M, Garda, A, Fattahi, S, Michel, A, Mutter, R, Yan, E, Park, S, Corbin, K, Giap, H, LAM, W.W, Geng, H, Tang, K.K, Lee, T.Y, Kong, C.W, Yang, B, Chiu, T.L, Cheung, K.Y, Yu, S.K, Ma, M, Gao, X, Zhao, Z, Zhao, B, Mullikin, T, Routman, D, Yu, J, Greco, K, Fagundes, M, Shan, J, Daniels, T, Rule, W, DeWees, T, Hu, Y, Bues, M, Sio, T, Liu, W, chenbin, L, yuehu, P, yuenan, W, Bai, Y, Gao, X.S, Zhao, Z.L, Ma, M.W, Ren, X.Y, Salem, A, Woolf, D, Aznar, M, Azadeh, A, Eccles, C, Charlwood, F, Faivre-Finn, C, Teoh, S, Fiorini, F, George, B, Vallis, K, Van den Heuvel, F, Huang, E.Y, Juang, P.J, Pan, S, Hawkins, M, Clarke, M, Lowe, M, Radhakrishna, G, Schaub, S, Bowen, S, Nyflot, M, Chapman, T, Apisarnthanarax, S, Vitek, P, Kubes, J, Vondracek, V, Vinakurau, S, Zamecnik, L, Vitolo, V, Barcellini, A, Brugnatelli, S, Cobianchi, L, Vanoli, A, Fossati, P, Facoetti, A, Dionigi, P, Orecchia, R, Iannalfi, A, Vischioni, B, Ronchi, S, D’Ippolito, E, Petrucci, R, Yamaguchi, H, Honda, M, Hamada, K, Todate, Y, Seto, I, Suzuki, M, Wada, H, Murakami, M, Yu, Z, Zheng, W, Lien-Chun, L, Zhengshan, H, Qing, Z, Jiade, L, Guoliang, J, Fiore, M.R, D'Ippolito, E, Fukumitsu, N, Hayakawa, T, Yamashita, T, Mima, M, Demizu, Y, Suzuki, T, Soejima, T, Hartsell, W, Collins, S, Casablanca, V, Mihalcik, S, Brennan, E, Van Nispen, A, Corbett, A, Mohammed, N, Lee, P, van Nispen, A, Liang, Y.S, Mein, S, Kopp, B, Choi, K, Haberer, T, Debus, J, Abdollahi, A, Mairani, A, Ogino, H, Iwata, H, Hashimoto, S, Nakajima, K, Hattori, Y, Nomura, K, Shibamoto, Y, Li, P, Wu, S, Deng, L, Zhang, G, Zhang, Q, Fu, S, Yang, Z, Zhang, Y, Sasaki, R, Okimoto, T, Akasaka, H, Miyawaki, D, Yoshida, K, Wang, T, Komatsu, S, Fukumoto, T, Shuang, W, Xin, C, zhengshan, H, Shen, F, Vorobyov, N, Andreev, G, Martynova, N, Lyubinsky, A, Kubasov, A, Chen, J, Ma, N, Lu, Y, Zhao, J, Shahnazi, K, Lu, J, Jiang, G, Mao, J, Walser, M, Bojaxhiu, B, Kawashiro, S, Tran, S, Pica, A, Bachtiary, B, Weber, D, Gaito, S, Abravan, A, Richardson, J, Colaco, R, Saunders, D, Brennan, B, Petersen, I, Ahmed, S, Laack, N, Mizoe, J.E, Iizumi, T, Minohara, S, Kusano, Y, Matsuzaki, Y, Tsuchida, K, Serizawa, I, Yoshida, D, Katoh, H, Sakurai, H, Tujii, H, Kim, T.H, Park, J.W, Bo Hyun, K, Hyunjung, K, Sung Ho, M, Sang Soo, K, Sang Myung, W, Young-Hwan, K, Woo Jin, L, Dae Yong, K, Hong, Z, Wang, Z, Koroulakis, A, Molitoris, J, Kaiser, A, Hanna, N, Jiang, Y, Regine, W, DeCesaris, C.M, Choi, J.I, Carr, S.R, Burrows, W.M, Regine, W.F, Simone, C.B, Aihara, T, Hiratsuka, J, Kamitani, N, Higashino, M, Kawata, R, Kumada, H, Ono, K, Chou, Y.C, Dippolito, E, Bonora, M, Alterio, D, Gandini, S, Jereczeck, B.A, Kelly, C, Dobeson, C, Iqbal, S, Chatterjee, S, Hague, C, Li, T, Lin, A, Lukens, J, Slevin, N, Thomson, D, van Herk, M, West, C, Teo, K, Jeans, E, Manzar, G, Patel, S, Ma, D, Lester, S, Foote, R, Friborg, J, Jensen, K, Hansen, C.R, Andersen, E, Andersen, M, Eriksen, J.G, Johansen, J, Overgaard, J, Grau, C, Dědečková, K, Vítek, P, Ondrová, B, Sláviková, S, Zapletalová, S, Zapletal, R, Vondráček, V, Rotnáglová, E, Kwanghyun, J, Woojin, L, Dongryul, O, Yong Chan, A, Paudel, N, Schmidt, S, Ruckman, M, Gans, S, Stauffer, M, Helenowski, I, Patel, U, Samant, S, Gentile, M, Damico, N, Yao, M, Shuja, M, Routman, D.M, Foote, R.L, Garces, Y.I, Neben-Wittich, M.A, Patel, S.H, McGee, L.A, Harmsen, W.S, Ma, D.J, Sommat, K, Tong, A.K.T, Hu, J, Ong, A.L.K, Wang, F, Sin, S.Y, Wee, T.S, Tan, W.K, Fong, K.W, Soong, Y.L, Wallace, N, Fredericks, S, Fitzgerald, T, Vernimmen, F, Petringa, G, Cirrone, P, Agosteo, S, Attili, A, Cammarata, F.P, Cuttone, G, Conte, V, La Tessa, C, Manti, L, Rosenfeld, A, Lojacono, P.A, Hennings, F, Fattori, G, Peroni, M, Lomax, A, Hrbacek, J, Nguyen, H.G, Bach Cuadra, M, Sznitman, R, Schalenbourg, A, Pflaeger, A, Weber, A, Seidel, S, Stark, R, Heufelder, J, Mailhot Vega, R, Bradley, J, Lockney, N, Macdonald, S, Liang, X, Mazal, A, Mendenhall, N, Sher, D, Korreman, S.S, Andreasen, S, Petersen, J.B, Offersen, B.V, Gergelis, K, Jethwa, K, Whitaker, T, Shiraishi, S, Shumway, D, Press, R, Shelton, J, Zhang, C, Dang, Q, Tian, S, Shu, T, Seldon, C, Jani, A, Zhou, J, McDonald, M, Gort, E, Beukema, J.C, Spijkerman-Bergsma, M.J, Both, S, Langendijk, J.A, Matysiak, W.P, Brouwer, C.L, Baba, K, Numajiri, H, Murofushi, K, Oshiro, Y, Mizumoto, M, Onishi, K, Nonaka, T, Ishikawa, H, Okumura, T, Dominietto, M, Adam, K, Ahlhelm, F.J, Safai, S, Abdul-Jabbar, L, Song, J, Tseng, Y. D, Rockhill, J, Fink, J, Chang, L, Halasz, L. M, Guntrum, F, Steinmeier, T, Nagaraja, S, Jazmati, D, Geismar, D, Timmermann, B, Plaude, S, Lynch, C, Petras, K, Chang, J, Grimm, S, Lukas, R, Kumthekar, P, Merrell, R, Kalapurakal, J, Gross, J, Hoppe, B, Simone, C, Nichols, R.C, Pham, D, Mohindra, P, Chon, B, Morris, C, Li, Z, Flampouri, S, Powell, J.R, Murray, L, Burnet, N, Fernandez, S, Lingard, Z, McParland, L, O’Hara, D, Whitfield, G, Short, S.C, Guan, X, Gao, J, Hu, W, Yang, J, Xing, X, Hu, C, Kong, L, Zou, Z, Thomas, H, Sasidharan, B.K, Rengan, R, Zeng, J, Busold, S, Heese, J, Cerello, P, Bottura, L, Felcini, E, Ferrero, V, Monaco, V, Pennazio, F, de Rijk, G, Chang, H, KyungDon, C, Byunghun, H, Gyuseong, C, Chilukuri, S, Jalali, R, Panda, P.K, Korn, G, Larosa, G, Russo, A, Schillaci, F, Scuderi, V, Margarone, D, Fredén, E, Almhagen, E, Mejaddam, Y, Siegbahn, A, Guardiola, C, Gómez, F, Prieto-Pena, J, Fleta, C, De Marzi, L, Prezado, Y, Kabolizadeh, P, Reitemeier, P, Navin, M, Hamstra, D, Anderson, J, Stevens, C, Bartolucci, L, Adrien, C, Lejars, M, Vaillant, M, Fourquet, A, Robillard, M, Costa, E, Kirova, Y, Kolano, A.M, Degiovanni, A, Farr, J.B, Kundel, S, Pinto, M, Kurichiyanil, N, Würl, M, Englbrecht, F, Hillbrand, M, Schreiber, J, Parodi, K, Kurup, A, Magliari, A, Perez, J, Masui, S, Asano, T, Owen, H, Burt, G, Apsimon, R, Pitman, S, Popovici, M.A, Vasilache, R, Safavi-Naeini, M, Chacon, A, Howell, N, Middleton, R.J, Fraser, B, Guatelli, S, Rendina, L, Matsufuji, N, Gregoire, M.C, Sikora, K, Pettingell, J, Crocker, M, Saplaouras, A, Snijders, A, Mao, J.H, Nakamura, K, Bin, J, Gonsalves, A, Mao, H.S, Steinke, S, Roach, M, Leemans, W, Blakely, E, Takayama, K, Tan, T.S, Wee, J.T.S, Tuan, J.K.L, Wang, M.L.C, Quah, J.S.H, Tay, N.C.W, Lee, J.C.L, Lim, J.K.H, Oei, A.A, Tan, J.M, Park, S.Y, Chow, W.W.L, Omar, Y.B, Chew, P.G, Taylor, P, Lee, J, Tsurudome, T, Hirabayashi, M, Tsutsui, H, Yoshida, J, Takahashi, N, Kamiguchi, N, Hashimoto, A, Tachikawa, T, Mikami, Y, Kumata, Y, Wang, M, Chua, E.T, Wee, J, Wong, F.Y, Tuan, J, Master, Z, Wong, S, Welsh, J, Hentz, C, Pankuch, M, DeJongh, F, Xia, Y, Aitkenhead, A.H, Appleby, R, Merchant, M.J, MacKay, R.I, Young, H, Hughes, V, Alsulimane, M, Barajas, C.A, Taylor, J, Casse, G, Omar, A, Burdin, S, Boon, C, Lester, J, Thomas, A.J, Khan, A, Huthart, L, Leaver, K, Snell, J, Warlow, A, Burigo, L.N, Oborn, B, Belosi, F, Fredh, A, van de Water, S, Schneider, T, Patriarca, A, Bergs, J, Hierso, E, Hirayama, R, Martínez-Rovira, I, Seksek, O, Shirato, H, Nakamura, T, Ogino, T, Akimoto, T, Tamamura, H, Nishimoto, N, Proton-Net, G, Shimizu, S, Fabiano, S, Bangert, M, Guckenberger, M, Unkelbach, J, Mcauley, G, Teran, A, Slater, J, Wroe, A, Boon, I, Clorley, J, Owen, K, Oliver, T, Cicchetti, A, Ballarini, F, Rancati, T, Carrara, M, Zaffaroni, N, Bezawy, R. El, Carante, M, Valdagni, R, Faccini, R, Forte, G.I, Dhinsey, S, Greenshaw, T, Parsons, J, Welsch, C, Stock, M, Grevillot, L, Kragl, G, Carlino, A, Martino, G, Hug, E, Arya, H, Chirayath, V.A, Jin, M, Weiss, A.H, Glass, G.A, Chi, Y, Kaplan, L.P, Perez, R.A, Vestergaard, A, Gittings, E, Stamper, J, Beltran, C, Mark, P, Furutani, K, McAuley, G, Gordon, J, Boisseau, P, Dart, A, Nett, W, Kollipara, S, Grossmann, M, Actis, O, Diete, W, Rudolf, D, Klein, H.U, Kramert, R, Meer, D, Venkataraman, C, Waterstradt, T, Hérault, J, Bergerot, J.M, Hsi, W.C, Zhou, R, Zhang, X, Yang, F, Yinxiangzi, S, Sun, J, Li, X, Zhiling, C, Yuehu, P, Mengya, G, Haiyun, K, Qi, L, Zhentang, Z, Lin, Y.H, Tan, H.Q, Tan, L.K.R, Ang, K.W, Xiufang, L, Milkowski, K, Pang, D, Jones, M, Mizota, M, Tsunashima, Y, Himukai, T, Ogata, R, Uno, T, Ouyang, L, Jia, B, Li, D, Paul, K, Pullia, M, Savazzi, S, Lante, V, Foglio, S, Donetti, M, Falbo, L, Casalegno, L, Rousseau, M, Shinomiya, K, Yazawa, T, Iseki, Y, Kanai, Y, Hirata, Y, Powers, J, Solovev, A, Chernukha, A, Saburov, V, Shegai, P, Ivanov, S, Kaprin, A, Stolarczyk, L, Mojżeszek, N, Van Hoey, O, Farah, J, Domingo, C, Mares, V, Ploc, O, Trinkl, S, Harrison, R, Toltz, A, Nevitt, Z, Bloch, C, Taddei, P, Saini, J, Regmi, R, Yuntao, S, Jinxing, Z, Yap, J.S.L, Hentz, M, Silverman, J, Jolly, S, Boogert, S, Nevay, L, Kacperek, A, Schnuerer, R, Resta-Lopez, J, Zeng, X, Zheng, J, Li, M, Han, M, Song, Y, Holm, A, Korreman, S, Petersen, J.B.B, Bäumer, C, Fuenstes, C, Janson, M, Matic, A, Wulff, J, Psoroulas, S, Lomax, T, Arjomandy, B, Athar, B, Tesfamicael, B, Bejarano Buele, A, Deemer, J, Kozlyuk, V, VanSickle, K, Bolt, R, van Goethem, M.J, Langendijk, J, van t Veld, A, Chen, K.L, Wlodarczyk, B, Wu, H, Chen, Z, Shen, L, Fachouri, N, Placidi, L, Böhlen, T, Ieko, Y, Iwai, T, Nemoto, K, Suzuki, K, Kanai, T, Miyasaka, Y, Harada, M, Yamashita, H, Kubota, I, Kayama, T, Jensen, M.F, Bræmer-Jensen, P, Randers, P, Søndergaard, C.S, Nørrevang, O, Taasti, V.T, Kong, H, Yin, C, Gu, M, Liu, M, Shu, H, Chongxian, Y, Haiyang, Z, Juan, Z, Ming, L, Manzhou, Z., Liying, Z, Kecheng, C, Xiaolei, D, Castro, J, Freire, J, Cremades, M, Moral, L, Rico, P, Ares, C, Miralbell, R, Shi, J, Xia, J, Wang, B, Li, Q, Liu, X, Sung, C.C, Chen, W.P, Liao, T.Y, Takashina, M, Hamatani, N, Tsubouchi, T, Yagi, M, Mizoe, J, Titt, U, Mirkovic, D, Yepes, P, Wang, Q, Grosshans, D, Wieser, H.P, Mohan, R, Vadrucci, M, Xiao, G, Cai, X, Li, G, Yuan, Y, Lu, R, Sun, G, Zhang, M, Deming, L, lianhua, O, Takada, K, Tanaka, S, Matsumoto, Y, Naito, F, Kurihara, T, Nakai, K, Matsumura, A, Sakae, T, Shamurailatpam, D, P, K, Mp, N, A, M, Kg, G, T, R, C, S, J, R, Rozes, A, Dutheil, P, Batalla, A, Vela, A, Rana, S, Bennouna, J, Gutierrez, A, He, P, Shen, G, Dai, Z, Ma, Y, Chen, W, Pandey, J, Chirvase, C, Osborne, M, Ilsley, E, Di Biase, I, Kato, T, Hirose, K, Arai, K, Motoyanagi, T, Harada, T, Takeuchi, A, Kato, R, Tanaka, H, Mitsumoto, T, Takai, Y, Bolsa-Ferruz, M, Palmans, H, Chen, Y.S, Wu, S.W, Huang, H.C, Wang, H.T, Yeh, C.Y, Chen, H.H, Cook, H, Lourenço, A, Dal Bello, R, Magalhaes Martins, P, Hermann, G, Kihm, T, Seimetz, M, Brons, S, Seco, J, De Saint-Hubert, M, Swakon, J, De Freitas Nascimento, L, Tessaro, V.B, Poignant, F, Gervais, B, Beuve, M, Galassi, M.E, Harms, J, Chang, C.W, Zhang, R, Lin, Y, Langen, K, Liu, T, Lin, L, Howard, M, Denbeigh, J, Remmes, N, Debrot, E, Herman, M, Huang, Y.Y, Tsai, S.H, Fang, F.M, Mizuno, H, Sagara, T, Yamazaki, Y, Kato, M, Oyama, S, Pembroke, C, Joslin-Tan, T, Maggs, R, O’Neil, K, Barrett-Lee, P, Staffurth, J, Resch, A, Heyes, P, Georg, D, Fuchs, H, Hideyuki, M, katsuhisa, N, Wataru, Y, Samnøy, A.T, Ytre-Hauge, K.S, Povoli, M, Kok, A, Summanwar, A, Linh, T, Malinen, E, Röhrich, D, Asp, J, Santos, A, Afshar, V.S, Zhang, W.Q, Bezak, E, a, M, k, G, p, K, mp, N, t, R, c, S, j, R, Smith, B, Hammer, C, Hyer, D, DeWerd, L, Culberson, W, Brooke, M, Straticiuc, M, Craciun, L, Matei, C.E, Radu, M, Xiao, M, Paschalis, S, Joshi, P, Price, T, Mehta, M, Graça, J, Biglin, E, Aitkenhead, A, Price, G, Williams, K, Chadwick, A, Schettino, G, Robinson, A, Kirkby, K, Catanzano, D, Cessac, R, Rutherford, R, Ahmed, A, Mohammadi, A, Tashima, H, Yamaya, T, Chavez Barajas, C, Taylor, A, Vossebeld, J, Barwick, I, CHEON, W, Jo, K, Ahn, S.W, Cho, J, Han, Y, Choi, H.H.F, Cheung, C.W, Cohilis, M, Lee, J.A, Sterpin, E, Souris, K, Mundy, D, Petasecca, M, Rosenfeld, A.B, Boso, A, Di Fulvio, A, Becchetti, F.D, Torres-Isea, R.O, Febbraro, M, Gagnon-Moisan, F, Feng, Y, Fontana, M, Etxebeste, A, Dauvergne, D, Letang, J.M, Testa, E, Sarrut, D, Maxim, V, Gajewski, J, Durante, M, Garbacz, M, Krah, N, Krzempek, K, Schiavi, A, Skrzypek, A, Tommasino, F, Ruciński, A, Gillin, M, Sahoo, N, Zhu, X.R, Van Delinder, K.W, Crawford, D, Khan, R, Gräfe, J, Kakiuchi, G, Shioyama, Y, Shimokomaki, R, Huang, Z, Wang, W, Sheng, Y, Lee, M.W, Jan, M.L, Hong, J.H, Okamoto, K, Sato, H, Kalantan, S, Boston, A, Kang, Y, Shen, J, Casey, W, Vern-Gross, T, Wong, W, McGee, L, Halyard, M, Keole, S, Kelleter, L, Radogna, R, Saakyan, R, Basharina-Freshville, A, Attree, D, Volz, L, Komenda, W, Krzempek, D, Mierzwińska, G, Barbara, M, Kopeć, R, Lan, J.H, Chang, F.X, Lin, C.H, Lee, T.F, Ahn, S, Cheon, W, Lee, M, Letellier, V, Osorio, J, Dreindl, R, Livingstone, J, Gallin-Martel, M.L, Létang, J.M, Marcatili, S, Morel, C, Maggi, P, Chen, H, Yang, H, Panthi, R, Mackin, D, Peterson, S, Beddar, S, Polf, J, Masuda, T, Nishio, T, Sano, A, Tomozawa, H, Nishio, A, Tsuneda, M, Okamoto, T, Karasawa, K, Miszczynska Giza, O, Sánchez-Parcerisa, D, Herraiz, J. L, Rojo-Santiago, J, Udias, J.M, Mitrović, U, Hager, M, List, I, Fischer, C, Cecowski, M, Gajšek, R, Mizutani, S, Hotta, K, Baba, H, Tanizaki, N, Yamaguchi, T, Moon, S.Y, Rah, J.E, Yoon, M, Shin, D, Nebah, P, Dugas, J, Syh, J, Maynard, M, Marsh, N, Rosen, L, Nichiporov, D, Watts, D.A, Chen, Y, Petterson, M, Lee, W.D, Penfold, S.N, Ruebel, N, Piersimoni, P, Mille, M, Mossahebi, S, Chen-Mayer, H, Allport, P, Green, S, Shaikh, S, Walker, D, Qamhiyeh, S, Levegruen, S, Kutscher, S, Kranke, H, Olbrich, G, Stuschke, M, Baran, J, Pawlik-Niedzwiecka, M, Moskal, P, Rutherford, H, Poenisch, F, Martin, C, Wu, R, Mayo, L.L, Shah, S.J, Frank, S.J, Gunn, G.B, Sakurai, Y, Takata, T, Kondo, N, Schlegel, N, Deng, Y, Sun, W, Wu, X, Yap, J, Zhang, H, Szumlak, T, Schuy, C, Simeonov, Y, Zink, K, Graeff, C, Weber, U, Allred, B, Robertson, D, Dewees, T, Gagneur, J, Stoker, J, Stützer, K, Valentini, C, Agolli, L, Hölscher, T, Thiele, J, Dutz, A, Löck, S, Krause, M, Baumann, M, Richter, C, Takayanagi, T, Uesaka, T, Nakamura, Y, Unlu, M.B, Kuriyama, Y, Uesugi, T, Ishi, Y, Umegaki, K, Matsuura, T, Watts, D. A, Huisman, B, Valladolid Onecha, V, Fraile, L.M, Sanchez Parcerisa, D, España, S, Ze, W, Chen, H.Y, Chuang, K.S, Wilson, M, Lui, J, Noble, D, Holloway, S, Yap, J.H.H, Chew, M.M.L, Pang, P.P, Lim, C.J.C, Gan, S.A, Tan, T.W.K, Shen, Z.M, Moyers, M, Qianxia, W, Chen, H.L, Li, J, Lin, J, Zhao, L, Myers, W, Ates, O, Faught, J, Yan, Y, Faught, A, Sobczak, D, Hua, C.H, Moskvin, V, Merchant, T, Henkner, K, Ecker, S, Chaudhri, N, Ellerbrock, M, Jäkel, O, Hernandez Morales, D, Augustine, K, Johnson, J, Younkin, J, Fiorina, E, Mattei, I, Morrocchi, M, Sarti, A, Traini, G, Valle, S.M, Bert, C, Karger, C.P, Kamada, T, Scholz, M, DeLuca, P.M, De Simoni, M, Dong, Y, Embriaco, A, Fischetti, M, Mancini-Terracciano, C, Mirabelli, R, Muraro, S, Lens, E, de Blécourt, A, Schaart, D, Vos, F, van Dongen, K, Berthold, J, Khamfongkhruea, C, Petzoldt, J, Wohlfahrt, P, Pausch, G, Janssens, G, Smeets, J, Shamblin, J, Blakey, M, Moore, R, Matteo, J, Schreuder, N, Derenchuk, V, Shin, J, Jee, K.W, Clasie, B.M, Depauw, N, Batin, E, Madden, T.M, Schuemann, J, Paganetti, H, Kooy, H.M, Daniel, M, Abbassi, L, Arsène-Henry, A, Amessis, M, Maes, S, O’Ryan-Blair, A, Laval, G, Ermoian, R, Taddei, P. J, Andersson, K, Norrlid, O, Lindbäck, E, Vallhagen Dahlgren, C, Witt Nyström, P, Argota Perez, R, Sharma, M.B, Elstrøm, U.V, Bizzocchi, N, Albertini, F, Branco, D, Kry, S, Rong, J, Frank, S, Followill, D, Busch, K, Muren, L.P, Thörnqvist, S, Andersen, A.G, Pedersen, J, Dong, L, Cao, W, Bai, X, Van Lobenstein, N, Traneus, E, Anson, C, Comi, S, Marvaso, G, Russo, S, Giandini, T, Avuzzi, B, Ciardo, D, Cattani, F, Jereczek-Fossa, B, Cotterill, J, Esposito, M, Winter, A, Allinson, N, Liu, G, Yan, D, Jawad, S, Dilworth, J, Chen, P, Ackermann, B, Florijn, M, Sharfo, A.W.M, Wiggenraad, R.G.J, van Santvoort, J.P.C, Petoukhova, A.L, Hoogeman, M.S, Mast, M.E, Dirkx, M.L.P, Fujitaka, S, Fujii, Y, Nihongi, H, Nakayama, S, Ho, M.W, Artz, M, Tong, K.T.A, Hytonen, R, Koponen, T, Niemela, P, Iancu, G, Lautenschlaeger, S, Eberle, F, Horst, F, Ringbaek, T, Engenhart-Cabillic, R, Kim, M.J, Hong, C.S, Kim, Y.B, Park, S.H, Kim, J.S, Reiterer, J, Steffal, C, Gora, J, Kann, T, Schratter-Sehn, A.U, Li, H, Chen, M, wu, R, Li, Y, zhang, X, Gautam, A, poenisch, F, sahoo, N, Zhu, R, Lin, M, Chang, J.T.C, Maeda, Y, Sato, Y, Shibata, S, Bou, S, Yamamoto, K, Sasaki, M, Fuwa, N, Takamatsu, S, Kume, K, Lim, F, Faller, F, Stiller, W, Ming, X, Hui, H, Mukawa, T, Takashi, Y, Stephenson, L, Pang, E.P.P, Paz, A.E, Yoshida, Y, Righetto, R, Vecchi, C, Alparone, A, De Spirito, M, Radhakrishnan, S, Chandrashekaran, A, Nandigam, J, Sarma, Y, Rechner, L, Munck af Rosenschöld, P, Bäck, A, Johansen, T.S, Schut, D.A, Aznar, M.C, Nyman, J, Ren, X, Rosas, S, Vanderstraeten, R, Jyske, T, Jari, L, Yuenan, W, Henthorn, N, Warmenhoven, J, Merchant, M, Kirkby, N, Ranald, M, Stefanowicz, S, Zschaeck, S, Troost, E.G.C, Stubington, E, Ehrgott, M, Nohadani, O, Shentall, G, Sun, T, yin, Y, Lin, X, Yoshimura, T, Matsuo, Y, Yamazaki, R, Takao, S, Miyamoto, N, Toussaint, L, Indelicato, D.J, Lassen-Ramshad, Y, Kirby, K, Mikkelsen, R, Di Pinto, M, Høyer, M, Stokkevåg, C.H, Van Herk, M, Shortall, J, Green, A, Vasquez Osorio, E, Mackay, R, Navratil, M, Andrlik, M, Chiang, Y.Y, Yeh, Y.H, Yeh, Y.J, Chang, T.C, Eaton, B, Yang, X, Esiashvili, N, Gu, W, Ruan, D, O’Connor, D, Zou, W, Tsai, M.Y, Jia, X, Sheng, K, Hyde, C, Chen, P.Y, Deraniyagala, R, Petoukhova, A, Klaassen, L, Habraken, S, Jacobs, J, Sattler, M, Verhoeven, K, Klaver, Y, Widesott, L, Fracchiolla, F, Algranati, C, Scifoni, E, Scartoni, D, Farace, P, Kröniger, K, Bauer, J, Nilsson, R, Chen, X, Liu, R, Sun, B, Mutic, S, Zhang, T, Zhao, T, Kajdrowicz, T, Wochnik, A, Swakoń, J, Małecki, K, Michalec, B, Moffitt, G, Wootton, L, Hardemark, B, Sandison, G, Emery, R, Stewart, R, Reidel, C.A, Finck, C, Deisher, A, Mahajan, A, Michael, H, Ahn, S.H, Kwang Hyeon, K, Chankyu, K, Youngmoon, G, Shinhaeng, C, Se Byeong, L, Young Kyung, L, Haksoo, K, Dongho, S, Jong Hwi, J, Ali, Y, Monini, C, Maigne, L, Alshaikhi, J, D’Souza, D, Amos, R. A, Baumann, K.S, Gomà, C, Flatten, V, Lautenschläger, S, Abdel-Rehim, A, Wan Chan Tseung, H.S, Ma, J, Kamal Syed, H, Boscolo, D, Krämer, M, Fuss, M, Braunroth, T, Rabus, H, Baek, W.Y, Brown, H, Alshammari, H, Brownstein, J, Giantsoudi, D, Wang, C.C, Grassberger, C, Chen, C, Chan, M.F, Mah, D, Hojo, Y, Xu, C, Elia, A, Fung, A, Nguyen, B.N, Oyervides, M, Koska, B, Kamal Sayed, H, Kim, C, Kim, Y.J, Lee, S.B, Goh, Y, Cho, S, Jeong, J.H, Kim, H, Lim, Y.K, Koh, W.Y.C, Lew, W.S, Lee, C.L.J, Kollitz, E, Han, H, Kim, C.H, Kroll, C, Riboldi, M, Newhauser, W, Dedes, G, Fuglsang Jensen, M, Nyström, U.H, Skyt, P.S, Hoffmann, L, Sloth Møller, D, Dokic, I, Kuo, S.H, Tai, P.L, Cheng, S.W, Chong, N.S, Yeom, Y.S, Kuzmin, G, Griffin, K, Langner, U, Jung, J.W, Lee, C, Lee, C.C, Hsu, W, Chao, T.C, Liamsuwan, T, Pischom, N, Tangboonduangjit, P, Suchada, T, Zheng, D, Rutenberg, M, Dhabaan, A, Harrabi, S, MARAFINI, M, Gioscio, E, Yunsheng, D, Alphonse, G, Rodriguez Lafrasse, C, Testa, É, Morris, B, Asavaphatiboon, S, DeBlois, D, Yam, M, Sękowski, P, Skwira-Chalot, I, Matulewicz, T, Flynn, R, Verbeek, N, Smyczek, S, Brualla, L, Lei, Y, Ghavidel, B, Curran, W, Beitler, J, Yu, H.W, Jeng, S.C, Tsai, Y.C, Chiou, J.F, Yusa, K, Dai, T, Yuan, P, Shafai-Erfani, G, Shu, H.K, Pepin, M, Tryggestad, E.J, Abdel Rehim, A, Johnson, J.E, Herman, M.G, Lee, S.C, Sheu, R.J, Ödén, J, Ramos-Mendez, J, Perl, J, Faddegon, B, Alaka, B.G, Bentefour, E.H, Samuel, D, Biradar, B, Frusti, P, Den Otter, L.A, Kurz, C, Stanislawski, M, Landry, G, Meijers, A, Knopf, A.C, Dickmann, J, Wesp, P, Rit, S, Johnson, R.P, Bashkirov, V, Schulte, R.W, Hoyle, B, Johnson, R, Schulte, R, Weller, J, Cotterill, J.V, Waltham, C, Allport, P.P, Taylor, M, Rogers, J, Evans, P.M, Allinson, N.M, Henry, T, Ardenfors, O, Gudowska, I, Poludniowski, G, Dasu, A, Lai, Y, Yuncheng, Z, Yiping, S, Mingwu, J, Xun, J, Yujie, C, Meric, I, Mattingly, J, Moustafa, A, Skjerdal, K, Moteabbed, M, Harisinghani, M, Efstathiou, J.A, Lu, H.M, Kabuki, S, Mizowaki, T, Ofierzynski, R, Paysan, P, Strzelecki, A, Lucca, R, Patch, S, Mustapha, B, Santiago-Gonzalez, D, Pettersen, H.E.S, Sølie, J, Levegrün, S, Pöttgen, C, Meyer, E, Collins-Fekete, C.A, Bashkirov, V.A, Wang, Y.M, Sung, K.C, Wang, C.J, Wu, H.Y, Winter, M, Bauer, U, Hansmann, T, Naumann, J, Peters, A, Pilz, K, Troost, E, Yan, S, Greenhalgh, J, Li, S, Bortfeld, T, Flanz, J, Ytre-Hauge, K, Zhang, L, Sharp, G.C, Cascio, E.W, Flanz, J.B, Tang, J, Zhu, J, Zhang, J, Uh, J, Sarosiek, C, Ricci, J, Coutrakon, G, Ozoemelam, I, van der Graaf, E.R, Maciej, K, Zhang, N, Brandenburg, S, Dendooven, P, Niepel, K, Yohannes, I, Dietrich, O, Ertl-Wagner, B, Pappas, E, Sølie, J.R, Odland, O.H, Ghesquiere-Dierickx, L.M.H, Felix Bautista, R, Gehrke, T, Jakubek, J, Turecek, D, Martisikova, M, Malekzadeh, E, Rajabi, H, Kalantari Mahmoudabadi, F, Meschini, G, d’Arenzo, D, Comini, D, Huynh, M.T, Paganelli, C, Fontana, G, Mancin, A, Preda, L, Su, Z, Henderson, R, Nichols, C, Bryant, C, Mendenhall, W, Boyer, B, Geerebaert, Y, Gevin, O, Koumeir, C, Magniette, F, Manigot, P, Poirier, F, Servagent, N, Thiebaux, C, Verderi, M, Chen, Y.R, Anderle, K, Jeraj, R, Chuter, R, Allan, I, Patel, I, MacKay, R, Harrison, K, Hoole, A, Thomas, S, Jena, R, Liao, Z, Zhu, R.X, Freeman, M, Espy, M, Aulwes, E, Magnelind, P, Merrill, F, Neukirch, L, Sidebottom, R, Tang, Z, Tupa, D, Wilde, C, Shusharina, N, Fullerton, B, Adams, J, Sharp, G, Chan, A, Dolde, K, Naumann, P, Dávid, C, Kachelrieß, M, Saito, N, Pfaffenberger, A, Wolf, M, Lis, M, Moreau, J, Buttion, M, Molitoris, J.K, Simone-, C.B, Regele, H, Bula, C, Danuser, S, Kang, M, Lin, H, Ribeiro, C. O, Dumont, D, Terpstra, J, Knopf, A, Wagenaar, D, Kierkels, R, van der Schaaf, A, Scandurra, D, Sijtsema, M, Korevaar, E, van den Hoek, A, O’Neil, M, Chung, H, Sala, I, Ramirez, H, Guerrero, T, Mondlane, G, Butkus, M.B, Stewart, R.D, Carlson, D.J, Ingram, S, Ytre-Hauge, K. Smeland, Rørvik, E, Perales, A, Carabe, A, Baratto-Roldan, A, Kimstrand, P, Cortes-Giraldo, M, Bertolet, A, Barato-Roldan, A, Baiocco, G, Barbieri, S, Mei, Z, Fan, K, Tang, K, Wang, J, Zhu, H, Sung, W, McNamara, A, Tran, L.T, Qi, Y, Xu, X, Pei, X, Chiang, Y, Chien-Hau, C, Chung-Chi, L, Chuan-Jong, T, Tsi-Chian, C, Wang, L, Cao, J, Wang, X, Lin, E, Minami, K, Kondo, R, Khoei, S, Shirvalilou, S, Khoee, S, Jamali Raoufi, N, Karimi, M.R, Shakeri-Zadeh, A, Patera, V, Rinaldi, I, Sas-Korczynska, B, Deng, W, Karagounis, I, Huynh, K, Maity, A, Abel, E, Santa Cruz, G, Monti Hughes, A, Herrera, M, Trivillin, V, Portu, A, Garabalino, M, Schwint, A, Gonzalez, S, Saint Martin, G, Santa Cruz, I, Tamari, Y, Watanabe, T, Masunaga, S.I, Wittig, A, Nigg, D, Stecher-Rasmussen, F, Moss, R, Igawa, K, Akita, K, Akabori, K, Hattori, K.J, Arima, H, Motoyama, K, Higashi, T, Trivillin, V.A, Pozzi, E.C.C, Thorp1, S.I, Curotto1, P, Garabalino1, M.A, Itoiz, M.E, Santa Cruz, I.S, Ramos, P.S, Palmieri, M.A, Schwint, A.E, Gadan, M.A, Thorp, S.I, Curotto, P, Portu, A.M, Thorp, S, Trivillin, V. A, Schwint, A. E, Fukuo, Y, Kanemitsu, T, Fukumura, M, Kosaka, T, Hiramatsu, R, Kuroiwa, T, Miyatake, S, Kawabata, S, Kirihata, M, Goldfinger, J.A, Garabalino, M.A, Pozzi, E.C, Ramos, P, De Leo, L.N, Yu, Q, Engelbrecht, M, Sioen, S, Miles, X, Nair, S, Ndimba, R, Baeyens, A, Vandevoorde, C, Buizza, G, Meng, J, Takai, N, Ogami, M, Nakamura, S, Ohba, Y, Liu, R.F, Zhang, Q.N, Wang, X.H, Luo, H.T, Kong, Y.R, Jansen, J, Tirinato, L, Marafioti, M.G, Hanley, R, Yao, X.Q, Pagliari, F, Huang, C.Y, Wong, W.K.R, Ho, Y.W, Nam, P.H, Koryakin, S.N, Troshina, M.V, Koryakina, E.V, Potetnya, V.I, Baykuzina, R.M, Lychagin, A.A, Ulyanenko, S.E, Molinelli, S, Giuseppe, M, Tran, L, Bolst, D, James, B, Steinsberger, T, Alliger, C, Dahle, T.J, Rusten, E, Wright, P, Forsback, S, Silvoniemi, A, Minn, H, Andersson, S, Buti, G, Barragán Montero, A.M, Vasquez-Osario, E, Sabouri, P, Nkenge, K, Yi, B, Burigo, L, Greilich, S, Thomas, R, Clark, C, Lourenco, A, Oancea, C, Granja, C, Kodaira, S, Coplan, M, Graybill, J, Lutz, L, Shahi, C, Su, J.J, Thompson, A, Romano, F, Shipley, D, Hong, T.S, Labarbe, R, Wolfgang, J.A, Meyer, S, Bortfeldt, J, Lämmer, P, Schnürle, K, Peters, N, Möhler, C, Hofmann, C, Koschik, A, Bryce-Atkinson, A, Van Nugteren, J, De Rijk, G, Kirby, G, Dutoit, B, Vignati, A, Ahmadi Ganjeh, Z, Fausti, F, Giordanengo, S, Hammad Ali, O, Sacchi, R, Shakarami, Z, Cirio, R, Inoue, J, Tachibana, M, Shimizu, Y, Ochi, T, Amano, D, Miyashita, T, Cooley, J, Nyamane, S, Zwart, T, Wagner, M, Lu, M, Rosenthal, S, Hashimoto, T, Katoh, N, Tamura, H, Emert, F, Missimer, J, Eichenberger, P, Gmuer, C, Spengler, C, Kamp, F, Hofmaier, J, Reiner, M, Belka, C, Van Ooteghem, G, Dasnoy-Sumell, D, Geets, X, Chen, C.C, Galbreath, G, Shmulenson, R, Pinheiro de Almeida, I, van Elmpt, W, Vilches Freixas, G, Unipan, M, Verhaegen, F, Bosmans, G, Garcia, G, Cevallos Robalino, L, Guzman-Garcia, K, Vega-Carrillo, H.R, Gomez-Ros, J.M, Gallego, E, Hintenlang, K, Martin, M, Gupta, N, Meissner, J, Smathers, J, Ainsley, C, Yin, L, Jagt, T, Breedveld, S, van Haveren, R, Nout, R, Astreinidou, E, Staring, M, Heijmen, B, Hoogeman, M, Stokes, W, Matter, M, Nenoff, L, Toramatsu, C, Wakizaka, H, Nitta, M, Nishikido, F, Hirano, Y, Yoshida, E, Miller, J, Maris, A, Kalle, R, Franco, G, Kierkels, R.G.J, van den Hoek, J.G.M, Bijl, H.P, Dieters, M, Steenbakkers, R.J.H.M, Dejongh, F, DeJongh, E, Rykalin, V, Karonis, N, Ordonez, C, Duffin, K, Winans, J, Neph, R, Sanchez-Parcerisa, D, Lopez-Aguirre, M, Dolcet Llerena, A, Udias, J, Oxley, D, Besson, R, Meier, G, Nanz, A, Schorta, M, Fleury, E, Trnková, P, Erdal, E, Hassan, K, Beenakker, J.W, Pignol, J.P, Matysiak, W, Tian, L, Zepter, S, Winterhalter, C, Shim, S, Gouldstone, C, Trnkova, P, Vatnitsky, S, Liu, K, Li, E, Zhuangming, S, Lowenstein, J, De Wilde, O, Bossier, V, Lerot, X, Pouppez, A, Xx, X, Verburg, J, Hueso-Gonzalez, F, Ruggieri, T, Amato, C, Ghesquiere-Dierickx, L, Felix-Bautista, R, Deville, C, Barsky, A, Vapiwala, N, Mohamad, O, Tabuchi, T, Nitta, Y, Nomoto, A, Kasuya, G, Choy, H, Miyashiro, I, Bush, D, Chuong, M, Kozarek, J, Rubens, M, Larson, G, Vargas, C, Hung, S.P, Hsieh, C.E, Huang, B.S, Tsang, N.M, Smith, N, Viehman, J, Harmsen, W, Elswick, S, Boughey, J, Harless, C, Jimenez, R, Hickey, S, DePauw, N, Ho, A, Taghian, A, MacDonald, S, Meek, A, Hedrick, S, Baliga, S, Gallotto, S, Lewy, J, Patteson, B, Speroni, S, Omsberg, A, Tarbell, N, Musolino, P, Yock, T, Indelicato, D, Rotondo, R, Mailhot, R, Uezono, H, Bradfield, S, Agarwal, V, Gillies, C, Gosling, A, Casares-Magaz, O, Eskildsen, S.F, Lassen, Y, Hasle, H, Tofting-Olesen, K, Alapetite, C, Puget, S, Nauraye, C, Beccaria, K, Bolle, S, Doz, F, Sainte-Rose, C, Bouffet, E, Zerah, M, Wu, J, Qiu, X, Hua, W, Mao, Y, Frakulli, R, Kramer, P.H, Glas, M, Blase, C, Tippelt, S, Konrath, L, Gruber, N, Schallerbauer-Peter, A, Mock, U, Niyazi, M, Niemierko, A, Schapira, E, Kim, V, Oh, K.S, Hwang, W.L, Busse, P.M, Loeffler, J.S, Shih, H.A, Appel, H, Tseng, Y.D, Tsai, H, Sinesi, C, Rossi, C, Badiyan, S, Kotecha, R, Pike, L, Horick, N, Yeap, B, Franck, K, Wang, I, Loeffler, J, McKenna, M, Shih, H, Kountouri, M, Kole, A.J, Murray, F.R, Kliebsch, U, Combescure, C, iannalfi, A, Riva, G, Dougherty, J, Kruse, J, Iott, M, Brown, P, Olivier, K, Brodin, P, Kabarriti, R, Schechter, C, Kalnicki, S, Garg, M, Tomé, W, Lu, J.J, Chen, P.J, Dhanireddy, B, Severo, C, Lee, C.H, Lin, C.R, Rosier, L, Mathis, T, DeLaney, T, Lin, S, O’Meara, E, Powell, T, Hong, T, Hall, D, Liu, A, Ntentas, G, Dedeckova, K, Darby, S, Cutter, D, Zapletalova, S, Chen, Y.L, Miao, R, Lee, H, Hsiao-Ming, L, Choy, E, Cote, G, Eulitz, J, Lutz, B, Enghardt, W, Lühr, A, Mcmahon, S, Prise, K, Sung Hyun, L, Tansho, R, Mizushima, K, Warmenhoven, J.W, Hufnagl, A, Friedrich, T, Deycmar, S, Gruber, S, Dörr, W, Pruschy, M, Waissi, W, Burckel, H, Nicol, A, Noel, G, Yousef, I, Koizumi, M, Santa Cruz, G.A, González, S.J, Longhino, J, Provenzano, L, Oña, P, Rao, M, Cantarelli, M.D.L.Á, Leiras, A, Olivera, M.S, Alessandrini, P, Brollo, F, Boggio, E, Costa, H, Ventimiglia, R, Binia, S, Nievas, S.I, Langle, Y, Eijan, A.M, Colombo, L.L, Kawai, K, Nakamura, H, Natsuko, K, Masaki, H, Nakada, M, Furuse, M, Miyatake, S.I, Koivunoro, H, Kankaanranta, L, González, S, Joensuu, H, Sokol, O, Hild, S, Wiedemann, J, Köthe, A, Perry, D, Batie, M, Mascia, A, Sertorio, M, Luhr, A, Suckert, T, Müller, J, Beyreuther, E, Gotz, M, Haase, R, Schürer, M, Tillner, F, von Neubeck, C, Davis, A, Sishc, B, Saha, J, Ding, L, Story, M, Wagner, S, Kim, S.Y, Geary, S, Woodruff, T, Xu, T, Meng, Q, Gilchrist, S, Perentesis, J.P, Zheng, Y, Wells, S.I, Kong, Y, Liu, Y, Geng, Y, Knoll, M, Schwager, C, Schlegel, J, Schnölzer, M, Ding, L.H, Aroumougame, A, Chen, B, Saha, D, Pompos, A, Carter, R, Nickson, C, Thomson, J, Hill, M, Rodrigues, D, Snider, J, Sharma, A, Zakhary, M, Kara, L, Vujaskovic, Z, Dykstra, M, Best, T, Keane, F, Khandekar, M, Fintelmann, F, Willers, H, Singh, P, Eley, J, Malyapa, R, Mahmood, J, Hårdemark, B, Sandison, G.A, Wootton, L.S, Miyoaka, R.S, Laramore, G.E, Yang, P, van der Weide, H, Maduro, J, Heesters, M, Gawryszuk, A, Davila-Fajardo, R, Langendijk, H, Eckhard, M, Maxwell, A, VanNamen, K, Cashin, M, Jacovic, A, Dunn, M, kim, T, Jung, J, Kim, J, Swerdloff, S, Saunders, A, Thomas, J, Kidani, T, Okada, A, Tomida, K, Pennington, H, Xiaoqiang, L, Weigang, H, An, Q, Di, Y, Craig, S, Inga, G, Peyman, K, Xuanfeng, D, Cunningham, C, de Kock, M, Slabbert, J, Panaino, C.M, Phoenix, B, Regan, P.H, Shearman, R, Collins, S.M, Taylor, M.J, Grayson, M, Kato, K, Choi, H, Jang, J.W, Shin, W.G, Min, C.H, McMahon, S, Padilla Cabal, F, Fragoso, J.A, Resch, A.F, Katsis, A, Girdhani, S, Marshall, A, Jackson, I, Bentzen, S, Parry, R, Gantz, S, Schellhammer, S, Hoffmann, A, Delorme, R, Dos Santos, M, Salmon, R, Öden, J, Bullivant, K, Rucksdashal, R, Ferret, E, Covington, F, Rice, S, Decesaris, C, Siddiqui, O, Kowalski, E, Samanta, S, and Rothwell, B
- Subjects
Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0642 ,Physics: Absolute and Relative DosimetryPTC58-0180 ,Biology: Biology and Clinical InterfacePTC58-0685 ,Physics: Commissioning New FacilitiesPTC58-0385 ,Physics: 4D Treatment and DeliveryPTC58-0546 ,Clinics: EyePTC58-0714 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0528 ,Physics: Quality Assurance and VerificationPTC58-0507 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0661 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0221 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0531 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0653 ,Biology: Drug and Immunotherapy CombinationsPTC58-0163 ,Clinics: Sarcoma - LymphomaPTC58-0055 ,Biology: Drug and Immunotherapy CombinationsPTC58-0166 ,Clinics: CNS / Skull BasePTC58-0198 ,Physics: Treatment PlanningPTC58-0421 ,Clinics: PediatricsPTC58-0560 ,General: New HorizonsPTC58-0709 ,Physics: Treatment PlanningPTC58-0664 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0286 ,Physics: Treatment PlanningPTC58-0666 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0346 ,Physics: Treatment PlanningPTC58-0547 ,Physics: Treatment PlanningPTC58-0308 ,Physics: Treatment PlanningPTC58-0549 ,Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0111 ,Physics: Absolute and Relative DosimetryPTC58-0050 ,Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0587 ,Biology: Biology and Clinical InterfacePTC58-0454 ,Physics: Absolute and Relative DosimetryPTC58-0052 ,Physics: Commissioning New FacilitiesPTC58-0395 ,Physics: 4D Treatment and DeliveryPTC58-0534 ,Physics: Dose Calculation and OptimisationPTC58-0072 ,Physics: 4D Treatment and DeliveryPTC58-0533 ,Physics: 4D Treatment and DeliveryPTC58-0538 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0113 ,Physics: Quality Assurance and VerificationPTC58-0633 ,Physics: Treatment PlanningPTC58-0431 ,Physics: Beam Delivery and Nozzle DesignPTC58-0230 ,Biology: Mathematical Modelling SimulationPTC58-0179 ,Clinics: Head and Neck / EyePTC58-0365 ,Physics: Treatment PlanningPTC58-0319 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0697 ,Biology: Biology and Clinical InterfacePTC58-0663 ,Physics: Commissioning New FacilitiesPTC58-0240 ,Physics: Adaptive TherapyPTC58-0177 ,Physics: Commissioning New FacilitiesPTC58-0363 ,Physics: Commissioning New FacilitiesPTC58-0487 ,Physics: 4D Treatment and DeliveryPTC58-0209 ,Physics: 4D Treatment and DeliveryPTC58-0206 ,Clinics: CNS / Skull BasePTC58-0294 ,Physics: Commissioning New FacilitiesPTC58-0127 ,Biology: Mathematical Modelling SimulationPTC58-0068 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0062 ,Physics: 4D Treatment and DeliveryPTC58-0692 ,Physics: Quality Assurance and VerificationPTC58-0723 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0494 ,Physics: Treatment PlanningPTC58-0643 ,Physics: Treatment PlanningPTC58-0521 ,Physics: Treatment PlanningPTC58-0402 ,Physics: Treatment PlanningPTC58-0405 ,Clinics: Head and Neck / EyePTC58-0273 ,Clinics: GIPTC58-0397 ,Physics: Treatment PlanningPTC58-0648 ,Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0489 ,Physics: Quality Assurance and VerificationPTC58-0617 ,Physics: Quality Assurance and VerificationPTC58-0616 ,Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0668 ,Clinics: CNS / Skull BasePTC58-0188 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0625 ,Physics: Treatment PlanningPTC58-0654 ,Physics: Treatment PlanningPTC58-0655 ,Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0133 ,Clinics: PediatricsPTC58-0313 ,Physics: Treatment PlanningPTC58-0659 ,Poster AbstractsClinics: CNSPTC58-0290 ,Physics: Commissioning New FacilitiesPTC58-0064 ,Physics: Adaptive TherapyPTC58-0396 ,Physics: Dose Calculation and OptimisationPTC58-0281 ,Physics: Quality Assurance and VerificationPTC58-0427 ,Physics: Quality Assurance and VerificationPTC58-0669 ,General: New Horizons SessionPTC58-0191 ,Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0217 ,Physics: Quality Assurance and VerificationPTC58-0303 ,Physics: Quality Assurance and VerificationPTC58-0665 ,Clinics: Sarcoma - LymphomaPTC58-0495 ,Physics: Dose Calculation and OptimisationPTC58-0398 ,Physics: Quality Assurance and VerificationPTC58-0667 ,Physics: Quality Assurance and VerificationPTC58-0425 ,Physics: Quality Assurance and VerificationPTC58-0541 ,Physics: Treatment PlanningPTC58-0584 ,Physics: Quality Assurance and VerificationPTC58-0540 ,Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0163 ,Physics: Treatment PlanningPTC58-0224 ,Physics: Treatment PlanningPTC58-0229 ,Clinics: PediatricsPTC58-0249 ,Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0555 ,Clinics: PediatricPTC58-0463 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0556 ,Physics: Absolute and Relative DosimetryPTC58-0498 ,Physics: Commissioning New FacilitiesPTC58-0078 ,Physics: Dose Calculation and OptimisationPTC58-0270 ,Physics: Dose Calculation and OptimisationPTC58-0032 ,Physics: Dose Calculation and OptimisationPTC58-0274 ,Physics: 4D Treatment and DeliveryPTC58-0614 ,Physics: Dose Calculation and OptimisationPTC58-0026 ,Clinics: Head and Neck / EyePTC58-0280 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0091 ,Physics: Treatment PlanningPTC58-0593 ,Biology: Drug and Immunotherapy CombinationsPTC58-0012 ,Physics: Dose Calculation and OptimisationPTC58-0025 ,Physics: Dose Calculation and OptimisationPTC58-0146 ,Clinics: Sarcoma - LymphomaPTC58-0261 ,Physics: Treatment PlanningPTC58-0110 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0733 ,Physics: Quality Assurance and VerificationPTC58-0554 ,Physics: Treatment PlanningPTC58-0597 ,Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0330 ,Physics: Treatment PlanningPTC58-0115 ,Physics: Treatment PlanningPTC58-0598 ,Physics: Absolute and Relative DosimetryPTC58-0040 ,Physics: Absolute and Relative DosimetryPTC58-0282 ,Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0399 ,Physics: Absolute and Relative DosimetryPTC58-0283 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0569 ,Clinics: GUPTC58-0647 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0506 ,Physics: Commissioning New FacilitiesPTC58-0047 ,Physics: Dose Calculation and OptimisationPTC58-0067 ,Clinics: GUPTC58-0409 ,Physics: Dose Calculation and OptimisationPTC58-0065 ,Biology: BNCT Poster Discussion SessionsPTC58-0586 ,Physics: Absolute and Relative Dosimetry PTC58-0393 ,Physics: Image GuidancePTC58-0712 ,Physics: Quality Assurance and VerificationPTC58-0645 ,Physics: Treatment PlanningPTC58-0683 ,Biology: BNCT Poster Discussion SessionsPTC58-0107 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0266 ,Physics: Monitoring and Modelling MotionPTC58-0530 ,Biology: BNCT Poster Discussion SessionsPTC58-0341 ,Physics: Commissioning New FacilitiesPTC58-0172 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0456 ,Physics: Dose Calculation and OptimisationPTC58-0170 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0458 ,Physics: Absolute and Relative DosimetryPTC58-0034 ,Physics: Quality Assurance and VerificationPTC58-0417 ,Physics: Quality Assurance and VerificationPTC58-0413 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0492 ,Physics: Dose Calculation and OptimisationPTC58-0168 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0724 ,Physics: Treatment PlanningPTC58-0694 ,Physics: Adaptive TherapyPTC58-0005 ,Physics: Treatment PlanningPTC58-0696 ,Physics: Treatment PlanningPTC58-0453 ,Physics: Adaptive TherapyPTC58-0366 ,Clinics: BreastPTC58-0197 ,Physics: Beam Delivery and Nozzle DesignPTC58-0652 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0017 ,Physics: Treatment PlanningPTC58-0338 ,Clinics: Head and Neck / EyePTC58-0539 ,General: New Horizons SessionPTC58-0390 ,Physics: Image Guidance Poster Discussion SessionsPTC58-0651 ,General: New HorizonsPTC58-0660 ,Physics: Dose Calculation and OptimisationPTC58-0360 ,Physics: Image GuidancePTC58-0297 ,Physics: 4D Treatment and DeliveryPTC58-0147 ,Scientific: RTTPTC58-0388 ,Physics: Dose Calculation and OptimisationPTC58-0484 ,General: New HorizonsPTC58-0301 ,Physics: Dose Calculation and OptimisationPTC58-0485 ,General: New HorizonsPTC58-0304 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0532 ,Clinics: GIPTC58-0575 ,General: New HorizonsPTC58-0306 ,Physics: Quality Assurance and VerificationPTC58-0589 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0344 ,Physics: Quality Assurance and VerificationPTC58-0225 ,Physics: Treatment PlanningPTC58-0381 ,Physics: Quality Assurance and VerificationPTC58-0467 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0585 ,Physics: Commissioning New FacilitiesPTC58-0416 ,Physics: Quality Assurance and VerificationPTC58-0228 ,Physics: Quality Assurance and VerificationPTC58-0348 ,Physics: Dose Calculation and OptimisationPTC58-0234 ,Physics: Quality Assurance and VerificationPTC58-0101 ,Physics: Treatment PlanningPTC58-0386 ,Physics: Dose Calculation and OptimisationPTC58-0118 ,Physics: Treatment PlanningPTC58-0265 ,Physics: Dose Calculation and OptimisationPTC58-0119 ,Clinics: GIPTC58-0218 ,Physics: Treatment PlanningPTC58-0267 ,Physics: Treatment PlanningPTC58-0387 ,Clinics: BreastPTC58-0142 ,Physics: Treatment PlanningPTC58-0269 ,Physics: Beam Delivery and Nozzle DesignPTC58-0620 ,Clinics: PediatricsPTC58-0048 ,Physics: Quality Assurance and VerificationPTC58-0220 ,Physics: Quality Assurance and VerificationPTC58-0461 ,Physics: Treatment PlanningPTC58-0029 ,Physics: Absolute and Relative DosimetryPTC58-0571 ,Physics: Image GuidancePTC58-0046 ,Clinics: GUPTC58-0557 ,Physics: Absolute and Relative DosimetryPTC58-0211 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0131 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0373 ,General: New HorizonsPTC58-0411 ,Physics: Dose Calculation and OptimisationPTC58-0595 ,Clinics: CNS / Skull BasePTC58-0361 ,General: New HorizonsPTC58-0414 ,General: New HorizonsPTC58-0537 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0628 ,Physics: Treatment PlanningPTC58-0271 ,Physics: Commissioning New FacilitiesPTC58-0307 ,Physics: Quality Assurance and VerificationPTC58-0359 ,Physics: Quality Assurance and VerificationPTC58-0354 ,General: New HorizonsPTC58-0419 ,Physics: Treatment PlanningPTC58-0035 ,Biology: BNCTPTC58-0474 ,Clinics: GIPTC58-0460 ,Biology: BNCTPTC58-0596 ,Clinics: GIPTC58-0222 ,Physics: Image GuidancePTC58-0193 ,Clinics: PediatricPTC58-0312 ,Clinics: GUPTC58-0441 ,Clinics: LungPTC58-0701 ,Clinics: EyePTC58-0536 ,Clinics: GUPTC58-0205 ,Physics: Dose Calculation and OptimisationPTC58-0140 ,Clinics: GUPTC58-0208 ,Physics: Dose Calculation and OptimisationPTC58-0020 ,Physics: Image GuidancePTC58-0195 ,Poster AbstractsClinics: CNSPTC58-0717 ,Physics: Quality Assurance and VerificationPTC58-0325 ,Physics: Dose Calculation and OptimisationPTC58-0015 ,Physics: Commissioning New FacilitiesPTC58-0634 ,General: New HorizonsPTC58-0646 ,Physics: Quality Assurance and VerificationPTC58-0566 ,Physics: Dose Calculation and OptimisationPTC58-0134 ,Physics: Dose Calculation and OptimisationPTC58-0376 ,Biology: Mathematical Modelling SimulationPTC58-0462 ,Biology: BNCTPTC58-0567 ,General: New HorizonsPTC58-0527 ,Physics: Treatment PlanningPTC58-0482 ,Clinics: GI, GU, BreastPTC58-0693 ,Physics: Commissioning New FacilitiesPTC58-0518 ,Physics: Quality Assurance and VerificationPTC58-0686 ,Physics: Quality Assurance and VerificationPTC58-0202 ,Physics: Quality Assurance and VerificationPTC58-0322 ,Physics: Quality Assurance and VerificationPTC58-0564 ,Physics: Quality Assurance and VerificationPTC58-0680 ,Physics: Treatment PlanningPTC58-0247 ,Physics: Quality Assurance and VerificationPTC58-0682 ,Physics: Quality Assurance and VerificationPTC58-0440 ,Biology: Translational and BiomarkersPTC58-0514 ,Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0178 ,Clinics: EyePTC58-0520 ,Physics: Absolute and Relative DosimetryPTC58-0231 ,Clinics: Head and Neck / EyePTC58-0424 ,Physics: Absolute and Relative DosimetryPTC58-0471 ,Physics: Absolute and Relative DosimetryPTC58-0356 ,Physics: Dose Calculation and OptimisationPTC58-0491 ,Physics: Dose Calculation and OptimisationPTC58-0250 ,Physics: Commissioning New FacilitiesPTC58-0650 ,Biology: Biology and Clinical InterfacePTC58-0719 ,Physics: Absolute and Relative DosimetryPTC58-0232 ,Physics: Absolute and Relative DosimetryPTC58-0353 ,General: New HorizonsPTC58-0511 ,Physics: Quality Assurance and VerificationPTC58-0219 ,Physics: Absolute and Relative DosimetryPTC58-0238 ,General: New HorizonsPTC58-0512 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0401 ,Clinics: PediatricPTC58-0688 ,Physics: Quality Assurance and VerificationPTC58-0457 ,Physics: Quality Assurance and VerificationPTC58-0214 ,Physics: Quality Assurance and VerificationPTC58-0459 ,General: New HorizonsPTC58-0516 ,Physics: Treatment PlanningPTC58-0372 ,Physics: Treatment PlanningPTC58-0011 ,Physics: Treatment PlanningPTC58-0254 ,Physics: Quality Assurance and VerificationPTC58-0332 ,Clinics: CNS / Skull BasePTC58-0468 ,Biology: Mathematical Modelling SimulationPTC58-0357 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0649 ,Physics: Dose Calculation and OptimisationPTC58-0006 ,Physics: Quality Assurance and VerificationPTC58-0212 ,Physics: Image Guidance Poster Discussion SessionsPTC58-0565 ,Physics: Treatment PlanningPTC58-0018 ,Physics: Treatment PlanningPTC58-0019 ,Clinics: BreastPTC58-0576 ,Clinics: Head and Neck / EyePTC58-0335 ,Clinics: Head and Neck / EyePTC58-0577 ,General: New HorizonsPTC58-0621 ,Physics: Absolute and Relative DosimetryPTC58-0426 ,Physics: Commissioning New Facilities Poster Discussion SessionsPTC58-0268 ,Physics: Absolute and Relative DosimetryPTC58-0423 ,Physics: Treatment PlanningPTC58-0184 ,Physics: Quality Assurance and VerificationPTC58-0149 ,Clinics: GIPTC58-0378 ,Clinics: GIPTC58-0257 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0662 ,General: New HorizonsPTC58-0627 ,Physics: Treatment PlanningPTC58-0186 ,Physics: Treatment PlanningPTC58-0185 ,Physics: Quality Assurance and VerificationPTC58-0144 ,Biology: BNCT Poster Discussion SessionsPTC58-0602 ,Physics: Treatment PlanningPTC58-0189 ,Physics: Dose Calculation and OptimisationPTC58-0315 ,Clinics: Head and neckPTC58-0300 ,General: New Horizons SessionPTC58-0347 ,Physics: Image GuidancePTC58-0082 ,Clinics: BreastPTC58-0443 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0629 ,Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0007 ,Physics: Commissioning New FacilitiesPTC58-0472 ,Clinics: GI, GU, BreastPTC58-0515 ,Physics: Dose Calculation and Optimisation Poster Discussion SessionsPTC58-0606 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0450 ,Physics: Absolute and Relative DosimetryPTC58-0657 ,Physics: Dose Calculation and OptimisationPTC58-0551 ,Physics: Treatment PlanningPTC58-0192 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0675 ,Physics: Treatment PlanningPTC58-0194 ,Physics: Dose Calculation and OptimisationPTC58-0544 ,Physics: Treatment PlanningPTC58-0199 ,Physics: Quality Assurance and VerificationPTC58-0037 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0207 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0434 ,Physics: Quality Assurance and VerificationPTC58-0036 ,Physics: Quality Assurance and VerificationPTC58-0278 ,Physics: Quality Assurance and VerificationPTC58-0394 ,Physics: Quality Assurance and VerificationPTC58-0151 ,Physics: Quality Assurance and VerificationPTC58-0154 ,Physics: Dose Calculation and OptimisationPTC58-0428 ,Clinics: BreastPTC58-0116 ,Biology: Enhanced Biology in Treatment Planning Poster Discussion SessionsPTC58-0435 ,Physics: Commissioning New FacilitiesPTC58-0681 ,Physics: Absolute and Relative DosimetryPTC58-0323 ,Physics: Dose Calculation and OptimisationPTC58-0583 ,Physics: Absolute and Relative DosimetryPTC58-0448 ,Clinics: CNS / Skull BasePTC58-0251 ,General: New HorizonsPTC58-0721 ,Physics: Absolute and Relative DosimetryPTC58-0203 ,Physics: Dose Calculation and OptimisationPTC58-0455 ,Physics: 4D Treatment and DeliveryPTC58-0130 ,Physics: Commissioning New FacilitiesPTC58-0679 ,Physics: Absolute and Relative DosimetryPTC58-0329 ,General: New HorizonsPTC58-0604 ,Physics: Absolute and Relative DosimetryPTC58-0449 ,Clinics: CNS / Skull BasePTC58-0132 ,General: New HorizonsPTC58-0607 ,Physics: Quality Assurance and VerificationPTC58-0122 ,Physics: Quality Assurance and VerificationPTC58-0243 ,Physics: Treatment PlanningPTC58-0165 ,Oral AbstractsPhysics: Dose Calculation and OptimisationPTC58-0437 ,Physics: 4D Treatment and DeliveryPTC58-0377 ,Physics: Quality Assurance and VerificationPTC58-0125 ,Physics: Quality Assurance and VerificationPTC58-0245 ,Physics: Dose Calculation and OptimisationPTC58-0337 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0334 ,Physics: Quality Assurance and VerificationPTC58-0121 ,General: New Horizons SessionPTC58-0563 ,General: New Horizons SessionPTC58-0321 ,Clinics: Head and Neck / EyePTC58-0477 ,Physics: Quality Assurance and VerificationPTC58-0480 ,Clinics: GUPTC58-0010 ,Clinics: EyePTC58-0684 ,Clinics: GUPTC58-0496 ,Clinics: Head and neckPTC58-0676 ,Clinics: GUPTC58-0137 ,Physics: Beam Delivery and Nozzle Design Poster Discussion SessionsPTC58-0256 ,Physics: 4D Treatment and DeliveryPTC58-0117 ,Physics: Absolute and Relative DosimetryPTC58-0552 ,Physics: Absolute and Relative DosimetryPTC58-0310 ,Physics: Absolute and Relative DosimetryPTC58-0672 ,Physics: Absolute and Relative DosimetryPTC58-0436 ,Physics: Dose Calculation and OptimisationPTC58-0452 ,Physics: Dose Calculation and OptimisationPTC58-0331 ,Physics: Commissioning New FacilitiesPTC58-0213 ,Biology: Mathematical Modelling SimulationPTC58-0272 ,Clinics: EyePTC58-0326 ,Physics: Commissioning New FacilitiesPTC58-0568 ,Physics: Dose Calculation and OptimisationPTC58-0444 ,Physics: Quality Assurance and VerificationPTC58-0379 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0095 ,Physics: Treatment PlanningPTC58-0053 ,Physics: Absolute and Relative DosimetryPTC58-0438 ,Physics: Absolute and Relative DosimetryPTC58-0317 ,Physics: Quality Assurance and VerificationPTC58-0497 ,Physics: Quality Assurance and VerificationPTC58-0375 ,Physics: Treatment PlanningPTC58-0056 ,Physics: 4D Treatment and DeliveryPTC58-0124 ,Clinics: GIPTC58-0009 ,Physics: Quality Assurance and VerificationPTC58-0014 ,Physics: Quality Assurance and VerificationPTC58-0374 ,Clinics: LungPTC58-0727 ,General: New Horizons SessionPTC58-0578 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0470 ,Clinics: LungPTC58-0204 ,Clinics: Head and neckPTC58-0227 ,Clinics: LungPTC58-0446 ,Physics: Quality Assurance and VerificationPTC58-0190 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0609 ,Clinics: LungPTC58-0689 ,General: New HorizonsPTC58-0021 ,General: New HorizonsPTC58-0262 ,Biology: BNCT Poster Discussion SessionsPTC58-0081 ,Clinics: GIPTC58-0726 ,General: New HorizonsPTC58-0145 ,Physics: Image GuidancePTC58-0573 ,General: New HorizonsPTC58-0027 ,General: New HorizonsPTC58-0028 ,Biology: Mathematical Modelling and SimulationPTC58-0148 ,Physics: Dose Calculation and OptimisationPTC58-0635 ,Physics: Image GuidancePTC58-0215 ,Physics: Image GuidancePTC58-0336 ,Poster AbstractsClinics: CNSPTC58-0535 ,Physics: Quality Assurance and VerificationPTC58-0187 ,Biology: BNCT Poster Discussion SessionsPTC58-0084 ,General: New Investigator SessionPTC58-0339 ,General: New Horizons SessionPTC58-0420 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0523 ,Biology: BNCT Poster Discussion SessionsPTC58-0088 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0112 ,Physics: Quality Assurance and VerificationPTC58-0182 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0615 ,Physics: Quality Assurance and VerificationPTC58-0080 ,Biology: BNCTPTC58-0085 ,Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0722 ,General: New HorizonsPTC58-0253 ,General: New HorizonsPTC58-0255 ,Clinics: PediatricPTC58-0703 ,General: New HorizonsPTC58-0499 ,Physics: Image Guidance Poster Discussion SessionsPTC58-0380 ,General: New HorizonsPTC58-0259 ,Clinics: GI, GU, BreastPTC58-0288 ,Clinics: GI, GU, BreastPTC58-0045 ,Physics: Absolute and Relative DosimetryPTC58-0619 ,Clinics: PediatricPTC58-0707 ,Physics: Quality Assurance and VerificationPTC58-0196 ,Physics: Quality Assurance and VerificationPTC58-0074 ,Physics: Quality Assurance and VerificationPTC58-0077 ,Biology: BNCT Poster Discussion SessionsPTC58-0073 ,Biology: BNCTPTC58-0075 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0093 ,Clinics: GUPTC58-0161 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0371 ,Physics: Monitoring and Modelling MotionPTC58-0181 ,General: New HorizonsPTC58-0120 ,General: New HorizonsPTC58-0362 ,General: New HorizonsPTC58-0364 ,Physics: Image GuidancePTC58-0473 ,Scientific: RTTPTC58-0641 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0296 ,General: New HorizonsPTC58-0004 ,General: New HorizonsPTC58-0128 ,Clinics: BreastPTC58-0316 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0236 ,General: New HorizonsPTC58-0008 ,General: New Investigator SessionPTC58-0673 ,Physics: Quality Assurance and VerificationPTC58-0167 ,Physics: Quality Assurance and VerificationPTC58-0289 ,Physics: Quality Assurance and VerificationPTC58-0284 ,General: New Horizons SessionPTC58-0522 ,Physics: Quality Assurance and VerificationPTC58-0164 ,Physics: Quality Assurance and VerificationPTC58-0285 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0623 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0502 ,Clinics: GUPTC58-0293 ,Biology: Translational and BiomarkersPTC58-0599 ,Biology: BNCTPTC58-0063 ,Clinics: LungPTC58-0656 ,General: New HorizonsPTC58-0592 ,Biology: BNCT Poster Discussion SessionsPTC58-0092 ,Poster AbstractsClinics: CNSPTC58-0302 ,Physics: Image GuidancePTC58-0464 ,General: New HorizonsPTC58-0352 ,Physics: Image GuidancePTC58-0465 ,General: New HorizonsPTC58-0476 ,Physics: Image GuidancePTC58-0100 ,General: New HorizonsPTC58-0235 ,Biology: Mathematical Modelling and SimulationPTC58-0349 ,Physics: Treatment PlanningPTC58-0094 ,Physics: 4D Treatment and Delivery Poster Discussion SessionsPTC58-0367 ,Physics: Dose Calculation and OptimisationPTC58-0400 ,Biology: Translational and BiomarkersPTC58-0244 ,Physics: Dose Calculation and OptimisationPTC58-0640 ,Biology: Mathematical Modelling and SimulationPTC58-0355 ,General: New Investigator SessionPTC58-0320 ,Physics: Quality Assurance and VerificationPTC58-0057 ,Physics: Quality Assurance and VerificationPTC58-0174 ,Physics: Quality Assurance and VerificationPTC58-0295 ,Physics: Dose Calculation and OptimisationPTC58-0529 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0123 ,Physics: Quality Assurance and VerificationPTC58-0171 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0049 ,Clinics: BreastPTC58-0731 ,General: New HorizonsPTC58-0223 ,General: New HorizonsPTC58-0102 ,General: New HorizonsPTC58-0466 ,Scientific: RTTPTC58-0503 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0389 ,General: New HorizonsPTC58-0108 ,General: New HorizonsPTC58-0109 ,Physics: Commissioning New FacilitiesPTC58-0736 ,Biology: Mathematical Modelling and SimulationPTC58-0343 ,Biology: Mathematical Modelling and SimulationPTC58-0342 ,Clinics: GI, GU, BreastPTC58-0237 ,Physics: Dose Calculation and OptimisationPTC58-0711 ,Biology: Mathematical Modelling and SimulationPTC58-0581 ,Clinics: GI, GU, BreastPTC58-0114 ,Clinics: Base of SkullPTC58-0730 ,Clinics: Head and neckPTC58-0383 ,Clinics: CNS / Skull BasePTC58-0559 ,Clinics: Base of SkullPTC58-0613 ,General: New HorizonsPTC58-0691 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0054 ,General: New HorizonsPTC58-0210 ,Clinics: BreastPTC58-0729 ,General: New HorizonsPTC58-0574 ,Clinics: GI, GU, BreastPTC58-0239 ,Scientific: RTTPTC58-0637 ,General: New HorizonsPTC58-0579 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0176 ,General: New HorizonsPTC58-0699 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0156 ,Biology: Mathematical Modelling and SimulationPTC58-0333 ,Biology: Translational and BiomarkersPTC58-0345 ,Physics: Image GuidancePTC58-0369 ,Physics: Commissioning New FacilitiesPTC58-0509 ,Biology: Mathematical Modelling SimulationPTC58-0658 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0051 ,General: New Investigator SessionPTC58-0548 ,Clinics: GI, GU, BreastPTC58-0241 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0412 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0024 ,Clinics: LungPTC58-0226 ,Biology: Biological Differences between Carbon, Proton and Photons Poster Discussion SessionsPTC58-0069 ,General: New HorizonsPTC58-0562 ,General: New HorizonsPTC58-0561 ,General: New HorizonsPTC58-0201 ,Biology: Mathematical Modelling and SimulationPTC58-0439 ,General: New HorizonsPTC58-0445 ,General: New HorizonsPTC58-0324 ,Physics: Image GuidancePTC58-0031 ,Biology: Mathematical Modelling and SimulationPTC58-0558 ,Physics: Image GuidancePTC58-0392 ,Biology: Mathematical Modelling and SimulationPTC58-0678 ,Physics: Beam Delivery and Nozzle DesignPTC58-0090 ,General: New Investigator SessionPTC58-0630 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0524 ,Physics: Commissioning New FacilitiesPTC58-0713 ,Clinics: GI, GU, BreastPTC58-0139 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0248 ,Clinics: CNS / Pediatrics / Lung Poster Discussion SessionsPTC58-0368 ,Biology: Enhanced Biology in Treatment PlanningPTC58-0519 ,General: New Horizons SessionPTC58-0720 ,Physics: Quality Assurance and VerificationPTC58-0083 ,General: New HorizonsPTC58-0311 ,General: New HorizonsPTC58-0674 ,General: New HorizonsPTC58-0553 ,Physics: Image GuidancePTC58-0023 ,Scientific: RTTPTC58-0612 ,General: New HorizonsPTC58-0677 ,Biology: Mathematical Modelling and SimulationPTC58-0545 ,Physics: Dose Calculation and OptimisationPTC58-0601 ,Physics: Dose Calculation and OptimisationPTC58-0725 ,Physics: Quality Assurance and VerificationPTC58-0098 ,Physics: Dose Calculation and OptimisationPTC58-0605 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0517 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0618 ,Physics: Monitoring and Modelling MotionPTC58-0481 ,Clinics: GI / Sarcoma Poster Discussion SessionsPTC58-0071 ,Physics: Adaptive TherapyPTC58-0351 ,Physics: 4D Treatment and DeliveryPTC58-0702 ,Physics: Image GuidancePTC58-0734 ,Physics: Image GuidancePTC58-0611 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0486 ,Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0442 ,Biology: Drug and Immunotherapy CombinationsPTC58-0327 ,Clinics: Head and Neck / EyePTC58-0096 ,Clinics: LungPTC58-0159 ,Physics: Treatment PlanningPTC58-0708 ,General: New HorizonsPTC58-0097 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0350 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0016 ,Physics: Adaptive TherapyPTC58-0104 ,Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0433 ,Physics: Image GuidancePTC58-0608 ,Biology: Translational and Biomarkers Poster Discussion SessionsPTC58-0610 ,Clinics: Head and neckPTC58-0058 ,Physics: Treatment PlanningPTC58-0715 ,Clinics: Head and neckPTC58-0298 ,Clinics: EyePTC58-0099 ,General: New HorizonsPTC58-0086 ,General: New HorizonsPTC58-0089 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0200 ,Poster AbstractsClinics: CNSPTC58-0157 ,Clinics: LungPTC58-0141 ,Clinics: LungPTC58-0260 ,Clinics: LungPTC58-0264 ,Physics: Image GuidancePTC58-0513 ,Physics: Image GuidancePTC58-0631 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0469 ,Biology: BNCT Poster Discussion SessionsPTC58-0384 ,Physics: Image GuidancePTC58-0639 ,Clinics: PediatricsPTC58-0700 ,Clinics: LungPTC58-0136 ,Clinics: BreastPTC58-0706 ,General: New HorizonsPTC58-0079 ,Biology: Drug and Immunotherapy Combinations Poster Discussion SessionsPTC58-0406 ,Clinics: Base of SkullPTC58-0382 ,Physics: Image GuidancePTC58-0624 ,Physics: Beam Delivery and Nozzle DesignPTC58-0173 ,Biology: Drug and Immunotherapy CombinationsPTC58-0358 ,Poster AbstractsClinics: CNSPTC58-0690 ,General: New HorizonsPTC58-0061 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0580 ,Physics: Monitoring and Modelling MotionPTC58-0162 ,Physics: Adaptive TherapyPTC58-0550 ,Physics: Adaptive TherapyPTC58-0430 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0103 ,General: New Investigator SessionPTC58-0252 ,Physics: Quality Assurance and VerificationPTC58-0704 ,Physics: Image GuidancePTC58-0418 ,Clinics: Base of SkullPTC58-0572 ,Clinics: Lung / Sarcoma / LymphomaPTC58-0106 ,Physics: Beam Delivery and Nozzle DesignPTC58-0022 ,Physics: Monitoring and Modelling MotionPTC58-0279 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0447 ,Physics: Treatment PlanningPTC58-0622 ,Clinics: PediatricsPTC58-0644 ,Biology: Biology and Clinical InterfacePTC58-0490 ,Clinics: CNS / Skull BasePTC58-0716 ,General: New HorizonsPTC58-0292 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0570 ,General: New HorizonsPTC58-0059 ,Physics: Quality Assurance and VerificationPTC58-0710 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0216 ,Physics: Image GuidancePTC58-0404 ,Physics: Image GuidancePTC58-0525 ,Physics: Image GuidancePTC58-0526 ,Poster AbstractsClinics: CNSPTC58-0328 ,Clinics: LungPTC58-0070 ,Clinics: Eye / Breast / Pelvis Poster Discussion SessionsPTC58-0135 ,Biology: BNCT Poster Discussion SessionsPTC58-0391 ,Physics: Treatment PlanningPTC58-0510 ,Physics: Treatment PlanningPTC58-0636 ,Physics: Treatment PlanningPTC58-0638 ,Physics: Image GuidancePTC58-0408 ,Physics: Absolute and Relative Dosimetry Poster Discussion SessionsPTC58-0632 ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0318 ,Biology: Enhanced Biology in Treatment PlanningPTC58-0246 ,Clinics: PediatricsPTC58-0504 ,General: New HorizonsPTC58-0160 ,Physics: Image Guidance Poster Discussion SessionsPTC58-0076 ,Physics: Monitoring and Modelling MotionPTC58-0143 ,Biology: Mathematical Modelling and SimulationPTC58-0718 ,Physics: Image GuidancePTC58-0671 ,Clinics: LungPTC58-0183 ,Physics: Image GuidancePTC58-0670 ,Report ,Physics: Treatment Planning Poster Discussion SessionsPTC58-0422 ,Biology: Biological Differences between Carbon / Proton and Photons Carbons / Proton and PhotonPTC58-0129 ,Physics: Adaptive Therapy Poster Discussion SessionsPTC58-0705 ,Biology: Enhanced Biology in Treatment PlanningPTC58-0258 ,General: New HorizonsPTC58-0030 ,General: New HorizonsPTC58-0150 ,Biology: Biology and Clinical InterfacePTC58-0479 ,General: New HorizonsPTC58-0153 ,Clinics: PediatricPTC58-0087 ,General: New HorizonsPTC58-0152 ,General: New HorizonsPTC58-0155 ,General: New HorizonsPTC58-0033 ,General: New HorizonsPTC58-0158 ,Physics: Image GuidancePTC58-0429 ,Biology: Translational and BiomarkersPTC58-0287 ,Physics: Adaptive TherapyPTC58-0403 ,Physics: Image GuidancePTC58-0309 - Published
- 2020
7. Experimental assessment of inter-centre variation and accuracy in SPR prediction within the EPTN
- Author
-
Peters, N., Wohlfahrt, P., Bolsi, A., Dahlgren, C.V., De Marzi, L., Ellerbrock, M., Fracchiolla, F., Free, J., Gomà, C., Góra, J., Kajdrowicz, T., MacKay, R., Molinelli, S., Nørrevang, O., Rinaldi, I., Rompokos, V., Van der Tol, P., Vermeren, Xavier, and Richter, C.
- Subjects
Medizin - Abstract
Purpose/Objective: The standard approach for CT-number to stopping-power-ratio (SPR) conversion in particle therapy is the use of a heuristic stepwise translation, a so-called Hounsfield look-up table (HLUT). It is defined by each treatment facility individually and depends on both the calibration method and CT scan protocol. A recent survey has shown broad variability in these parameters [1], making a simple comparison on HLUT level unfeasible. Hence, we present a comprehensive experimental evaluation of inter-centre variation and absolute accuracy in SPR prediction within the European Particle Therapy Network. Material/Methods: A head and a body phantom with 17 tissue surrogate inserts were scanned consecutively at the participating centres using their individual clinical scan protocol. The inserts were tissue-equivalent concerning particles; their composition and SPR were blinded for the participants. The SPR calculation was performed using each centre’s CT scan and HLUT (Fig.1).The inter- centre variation and absolute accuracy in SPR prediction were quantified for each tissue surrogate individually and then summarised into the relevant tissue groups: lung, soft tissues and bones. Finally, to evaluate the integral effect on range prediction for typical clinical beams traversing different tissues, for three simplified beam paths the determined SPR deviations were accumulated according to their respective tissue distribution. So far, data from 9 out of 17 participating centres was available. Results: A 2σ inter-centre variation in SPR prediction of 5.7% and 5.5% relative to water was determined for the bone inserts in the head and body setup, respectively. Comparable results were achieved for the lung tissue surrogates (6.4% and 2.2%). In the soft tissue region an overall higher accuracy was achieved with a variation below 0.9% in both setups and a mean SPR prediction accuracy below 0.5%. In the head setup, both lung tissues and bones were overestimated in most centres, while in the body setup the bones were underestimated (Fig. 2A). For the three exemplary beam paths, inter-centre variations in relative range were 1.5% on average. In specific centres, range deviations from reference exceeded 1.5% (Fig 2B). Conclusion: Large inter-centre variations in SPR prediction were observed in low- and high density tissue surrogates. The differences in deviation for bone between the two setups indicate a strong influence of scanning parameters such as the level of beam hardening correction, potentially resulting in range shifts of clinical relevance. As the study allows for a direct attribution of the measured deviations to the calibration methods and scan protocols used by the individual centres, it stresses the need for inter-centre standardisation. While this work addresses the accuracy in SPR prediction under idealised study conditions, a direct conclusion on overall range accuracy in patients is not possible. The study is currently still ongoing. [1] Taasti et al. 2018, phiRO 6 25-30
- Published
- 2019
8. Experimental assessment of inter-centre variation and accuracy in SPR prediction within the European Particle Therapy Network
- Author
-
Peters, N., Wohlfahrt, P., Bolsi, A., Marzi, L., Ellerbrock, M., Fracchiolla, F., Free, J., Gomà, C., Góra, J., Kajdrowicz, T., Mackay, R., Molinelli, S., Nørrevang, O., Rinaldi, I., Rompokos, V., Dahlgren, C. V., Tol, P., Vermeren, X., and Richter, C.
- Abstract
Purpose/Objective: Experimental evaluation of inter-centre variation and absolute accuracy in stopping-power-ratio (SPR) prediction within the European Particle Therapy Network. Material/methods: A head&body phantom with 17 tissue surrogate inserts were scanned consecutively at the participating centres using their individual clinical scan protocol. The SPR calculation was performed using each centre’s CT scan and HLUT (Fig.1). The inter-centre variation and absolute accuracy in SPR prediction were quantified for lung, soft tissues and bones. To evaluate the integral effect on range prediction for typical clinical beams traversing different tissues, for three simplified beam paths the determined SPR deviations were accumulated according to their respective tissue distribution. So far, data from 12 out of 17 participating centres was analysed. Results: A 2σ inter-centre variation in SPR prediction of 7.4% and 6.1% relative to water was determined for the bone inserts in the head and body setup, respectively. Comparable results were observed for the lung tissue surrogates (5.8% and 2.8%). In the soft tissues, smaller variations were achieved (1.4% and 1.2%). For the three exemplary beam paths, inter-centre variations in relative range were 2.1% on average. Moreover, absolute range deviations from reference exceeded 2% in specific centres (Fig 2B). Conclusion: Large inter-centre variations in SPR prediction were observed in low- and high density tissue surrogates. The differences in deviation for bone between the two setups indicate a strong influence of scanning parameters such as the level of beam hardening correction, potentially resulting in range shifts of clinical relevance. Hence, inter-centre standardisation is highly desirable.
- Published
- 2019
9. Investigation into the effects of high-Z nano materials in proton therapy
- Author
-
Ahmad, R, Royle, G, Lourenço, A, Schwarz, M, Fracchiolla, F, and Ricketts, K
- Subjects
Paper ,Silver ,Phantoms, Imaging ,Proton Therapy ,Metal Nanoparticles ,nanoparticles ,Gold ,Radiation Dosage ,Monte Carlo Method ,range shift ,Platinum - Abstract
High-Z nano materials have been previously shown to increase the amount of dose deposition within the tumour due to an increase in secondary electrons. This study evaluates the effects of high-Z nano materials in combination with protons, and the impact of proton energy, nanoparticle material and concentration. These effects were studied in silico through Monte Carlo simulation and experimentally through a phantom study, with particular attention to macroscale changes to the Bragg peak in the presence of nanoparticles. Three nanoparticle materials were simulated (gold, silver and platinum) at three concentrations (0.01, 0.1 and 6.5 mg ml(-1)) at two clinical proton energies (60 and 226 MeV). Simulations were verified experimentally using Gafchromic film measurements of gold nanoparticles suspended in water at two available high concentrations (5.5 mg ml(-1) and 1.1 mg ml(-1)). A significant change to Bragg peak features was evident, where at 226 MeV and 6.5 mg ml(-1), simulations of gold showed a 4.7 mm longitudinal shift of the distal edge and experimentally at 5.5 mg ml(-1), a shift of 2.2 mm. Simulations showed this effect to be material dependent, where platinum having the highest physical density caused the greatest shift with increasing concentration. A dose enhancement of 6% ± 0.05 and 5% ± 0.15 (60 MeV and 226 MeV, respectively) was evident with gold at 6.5 mg ml(-1) to water alone, compared to the 21% ± 0.53 observed experimentally as dose to film with 5.5 mg ml(-1) of gold nanoparticles suspended in water at 226 MeV. The introduction of nanoparticles has strong potential to enhance dose in proton therapy, however the changes to the Bragg peak distribution that occur with high concentrations need to be accounted for to ensure tumour coverage.
- Published
- 2016
10. OL67 - Dosimetric validation of a Monte Carlo based treatment planning system for pencil beam scanning proton therapy treatments in low density tissues
- Author
-
Fracchiolla, F., Galetto, M., Lorentini, S., Tommasino, F., and Schwarz, M.
- Published
- 2021
- Full Text
- View/download PDF
11. EP-1848 Inaccuracies in proton dose calculation may be as significant as setup and range uncertainties
- Author
-
Schwarz, M., Innocenzi, M., Giacomelli, I., Fracchiolla, F., Patera, V., and Righetto, R.
- Published
- 2019
- Full Text
- View/download PDF
12. EP-1837 A new hybrid approach to allow robust Monte Carlo-based multi-field optimization in proton therapy
- Author
-
Tommasino, F., Widesott, L., Fracchiolla, F., Lorentini, S., Righetto, R., Algranati, C., Scifoni, E., Dionisi, F., Scartoni, D., Amelio, D., Cianchetti, M., Schwarz, M., Amichetti, M., and Farace, P.
- Published
- 2019
- Full Text
- View/download PDF
13. EP-1777 Improvements in pencil beam algorithm in proton therapy: do we still need Monte Carlo in brain?
- Author
-
Widesott, L., Lorentini, S., Fracchiolla, F., Farace, P., and Schwarz, M.
- Published
- 2019
- Full Text
- View/download PDF
14. OC-0667 Experimental assessment of inter-centre variation and accuracy in SPR prediction within the EPTN
- Author
-
Peters, N., Wohlfahrt, P., Bolsi, A., Dahlgren, C.V., De Marzi, L., Ellerbrock, M., Fracchiolla, F., Free, J., Gomà, C., Góra, J., Kajdrowicz, T., MacKay, R., Molinelli, S., Nørrevang, O., Rinaldi, I., Rompokos, V., Van der Tol, P., Vermeren, X., and Richter, C.
- Published
- 2019
- Full Text
- View/download PDF
15. 221. A pre-absorber optimization technique for pencil beam scanning (PBS) proton therapy treatments
- Author
-
Fracchiolla, F., Fellin, F., Innocenzi, M., Lipparini, M., Cianchetti, M., Dionisi, F., Vennarini, S., and Schwarz, M.
- Published
- 2018
- Full Text
- View/download PDF
16. 7. Dosimetric effects of setup error, range and dose calculation uncertainties: comparison between Pencil Beam and Monte Carlo algorithm
- Author
-
Innocenzi, M., Fracchiolla, F., Righetto, R., Patera, V., and Schwarz, M.
- Published
- 2018
- Full Text
- View/download PDF
17. 1. Implementation of 4D proton therapy treatments with pencil beam scanning (PBS)
- Author
-
Fracchiolla, F., Schwarz, M., Dionisi, Francesco, Hild, Sebastian, Giacomelli, Irene, Lorentini, Stefano, Engwall, Erik, Esposito, Pier Giorgio, and Amichetti, Maurizio
- Published
- 2018
- Full Text
- View/download PDF
18. EP-2032: Implementation of 4D proton therapy treatments with pencil beam scanning (PBS)
- Author
-
Fracchiolla, F., Dionisi, F., Hild, S., Giacomelli, I., Lorentini, S., Engwall, E., Esposito, P.G., Amichetti, M., and Schwarz, M.
- Published
- 2018
- Full Text
- View/download PDF
19. OC-0087: Clinical validation of Monte Carlo dose calculation for pencil beam scanning proton therapy
- Author
-
Widesott, L., Lorentini, S., Fracchiolla, F., Farace, P., and Schwarz, M.
- Published
- 2018
- Full Text
- View/download PDF
20. SP-0031: Impact of beam modifiers and heterogeneities in dose calculation accuracy
- Author
-
Fracchiolla, F.
- Published
- 2018
- Full Text
- View/download PDF
21. PO-0875: Dosimetric effects of anatomical changes in proton therapy of head and neck (H&N) cancer
- Author
-
Miori, G., WIdesott, L., Fracchiolla, F., Lorentini, S., Farace, P., Righetto, R., Algranati, C., and Schwarz, M.
- Published
- 2017
- Full Text
- View/download PDF
22. EP-1371: Multipurpose dosimetry phantom for QA in PBS therapy systems with commercial measurement devices
- Author
-
Algranati, C., Bizzocchi, N., Farace, P., Fellin, F., Fracchiolla, F., Lorentini, F., Righetto, R., Widesott, L., and Schwarz, M.
- Published
- 2015
- Full Text
- View/download PDF
23. PO-0822: Towards 'matched' gantries in scanning beam protontherapy
- Author
-
Lorentini, S., Fracchiolla, F., and Schwarz, M.
- Published
- 2015
- Full Text
- View/download PDF
24. OC-0161: 'End to end' validation of a Monte Carlo code for independent dose calculation in a proton pencil beam scanning system
- Author
-
Fracchiolla, F., Lorentini, S., Widesott, L., Farace, P., and Schwarz, M.
- Published
- 2015
- Full Text
- View/download PDF
25. PO-1609 Clinical validation of a GPU-based MC dose engine of a commercial TPS for PBS proton therapy.
- Author
-
Fracchiolla, F., Engwall, E., Janson, M., Tamm, F., Lorentini, S., Fellin, F., Bertolini, M., Algranati, C., Righetto, R., Farace, P., Amichetti, M., and Schwarz, M.
- Subjects
- *
PROTON therapy , *ENGINES - Published
- 2021
- Full Text
- View/download PDF
26. PD-0040: Monte Carlo simulation tool for commissioning measurements corrections of a proton pencil beam scanning (PBS) mode
- Author
-
Fracchiolla, F., Lorentini, S., and Schwarz, M.
- Published
- 2014
- Full Text
- View/download PDF
27. PO-1611: Clinical implementation of liver cancer treatments with pencil beam scanning proton therapy.
- Author
-
Fracchiolla, F., Dionisi, F., Righetto, R., Widesott, L., Giacomelli, I., Cartechini, G., Farace, P., Bertolini, M., Amichetti, M., and Schwarz, M.
- Subjects
- *
PROTON therapy , *LIVER cancer , *CANCER treatment - Abstract
Poster: Physics track: Intra-fraction motion management PO-1611: Clinical implementation of liver cancer treatments with pencil beam scanning proton therapy F. Fracchiolla, F. Dionisi, R. Righetto, L. Widesott, I. Giacomelli, G. Cartechini, P. Farace, M. Bertolini, M. Amichetti, M. Schwarz. [Extracted from the article]
- Published
- 2020
- Full Text
- View/download PDF
28. Proton therapy treatment monitoring with the DoPET system: activity range, positron emitters evaluation and comparison with Monte Carlo predictions.
- Author
-
Muraro, S., Battistoni, G., Belcari, N., Bisogni, M. G., Camarlinghi, N., Cristoforetti, L., Guerra, A. Del, Ferrari, A., Fracchiolla, F., Morrocchi, M., Righetto, R., Sala, P., Schwarz, M., Sportelli, G., Topi, A., and Rosso, V.
- Published
- 2017
- Full Text
- View/download PDF
29. A simple PMMA phantom for daily QA energy checks in proton therapy.
- Author
-
Bizzocchi, N., Fracchiolla, F., and Schwarz, M.
- Abstract
Beam energy measurements are one of the most important data that every radiotherapy facility has to collect periodically as constancy check. In proton therapy, due to the energy selection system and to the shape of the Bragg peak, this check has to be performed daily. To demonstrate that reliable daily proton energy verification is achievable using a 2D array of ionization chambers (IC) combined with our PMMA phantom. The PMMA phantom is provided with three couples of wedges: thanks to these, Bragg peak is sampled at different depths and the image becomes a transposition on the transverse plane of the depth dose. Coupled wedges are necessary to compensate for set-up errors. Three wedges of different slopes (the first and lowest one is for energy from 70 to 100 MeV, the middle one from 100 to 140 MeV and the third and highest one from 140 to 226 MeV) are used to spread the depth dose of every single checked energy in a way that the distal penumbra can be properly detected by an adequate number of IC in the 2D Array device. A sensitivity test showed that the phantom is able to detect range variations greater than the threshold (2 mm). We designed and built a reliable phantom for the range verification. Moreover, the costs of this phantom are very low compared to other commercial solutions used for range verification in proton therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
30. PO-0804: Clinical applications of a Monte Carlo tool of a proton pencil beam scanning delivery system.
- Author
-
Fracchiolla, F. and Schwarz, M.
- Subjects
- *
CANCER treatment , *PROTON therapy , *DRUG delivery systems , *MONTE Carlo method , *IONIZING radiation dosage - Published
- 2016
- Full Text
- View/download PDF
31. A.77 - A new phantom for daily QA in protontherapy: A fast, reliable and inexpensive solution.
- Author
-
Fracchiolla, F., Bizzocchi, N., Algranati, C., and Schwarz, M.
- Published
- 2016
- Full Text
- View/download PDF
32. A.76 - Improving the quality of protontherapy treatment plans and their verification with Monte Carlo methods.
- Author
-
Fracchiolla, F. and Schwarz, M.
- Published
- 2016
- Full Text
- View/download PDF
33. PO-0822 IMPACT OF SYSTEMATIC BEAM DELIVERY ERRORS ON THE DOSE DISTRIBUTION IN PROTON THERAPY WITH PENCIL BEAM SCANNING
- Author
-
Fracchiolla, F., Gargano, G., Bellotti, R., Cafagna, F.S., and Schwarz, M.
- Published
- 2012
- Full Text
- View/download PDF
34. ESTRO-ACROP guideline on surface guided radiation therapy.
- Author
-
Freislederer, P., Batista, V., Öllers, M., Buschmann, M., Steiner, E., Kügele, M., Fracchiolla, F., Corradini, S., de Smet, M., Moura, F., Perryck, S., Dionisi, F., Nguyen, D., Bert, C., and Lehmann, J.
- Subjects
- *
RADIOTHERAPY , *COMPUTED tomography , *PATIENT positioning , *LINEAR accelerators , *QUALITY assurance - Abstract
• First European guideline on Surface Guided Radiation Therapy (SGRT) • Collection of criteria for decision-making for procurement of an SGRT system. • Overview of staff roles and responsibilities and common and potential errors in SGRT workflows. • Recommendations for acceptance and commissioning. • Comprehensive guidelines for QA procedures and QA frequency. Surface guidance systems enable patient positioning and motion monitoring without using ionising radiation. Surface Guided Radiation Therapy (SGRT) has therefore been widely adopted in radiation therapy in recent years, but guidelines on workflows and specific quality assurance (QA) are lacking. This ESTRO-ACROP guideline aims to give recommendations concerning SGRT roles and responsibilities and highlights common challenges and potential errors. Comprehensive guidelines for procurement, acceptance, commissioning, and QA of SGRT systems installed on computed tomography (CT) simulators, C-arm linacs, closed-bore linacs, and particle therapy treatment systems are presented that will help move to a consensus among SGRT users and facilitate a safe and efficient implementation and clinical application of SGRT. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
35. PO-1425: Secondary cancer risk in breast cancer patients treated with protons compared to 3D-CRT and VMAT.
- Author
-
Tommasino, F., Cartechini, G., Fracchiolla, F., Menegotti, L., Scifoni, E., La Tessa, C., Schwarz, M., and Farace, P.
- Subjects
- *
BREAST cancer , *CANCER patients , *PROTONS , *RADIATION protection - Abstract
Poster: Physics track: Radiation protection, secondary tumour induction and low dose PO-1425: Secondary cancer risk in breast cancer patients treated with protons compared to 3D-CRT and VMAT F. Tommasino, G. Cartechini, F. Fracchiolla, L. Menegotti, E. Scifoni, C. La Tessa, M. Schwarz, P. Farace. [Extracted from the article]
- Published
- 2020
- Full Text
- View/download PDF
36. PO-1766 Validation of layer rescanning techniques for mediastinal treatments in proton therapy with PBS.
- Author
-
Castiglione Minischetti, G., Schwarz, M., Engwall, E., and Fracchiolla, F.
- Subjects
- *
PROTON therapy , *MEDIASTINUM , *THERAPEUTICS - Published
- 2021
- Full Text
- View/download PDF
37. PO-1241: Clinical results and toxicities in pediatric CNS tumors treated with proton pencil-beam scanning.
- Author
-
Rombi, B., Ruggi, A., Ronchi, L., Buwenge, M., Ammendolia, I., Cammelli, S., Melchionda, F., Prete, A., Fracchiolla, F., Zucchelli, M., Morganti, G., and Amichetti, M.
- Subjects
- *
PROTONS , *TUMORS - Abstract
Poster: Clinical track: Paediatric tumours PO-1241: Clinical results and toxicities in pediatric CNS tumors treated with proton pencil-beam scanning B. Rombi, A. Ruggi, L. Ronchi, M. Buwenge, I. Ammendolia, S. Cammelli, F. Melchionda, A. Prete, F. Fracchiolla, M. Zucchelli, G. Morganti, M. Amichetti. [Extracted from the article]
- Published
- 2020
- Full Text
- View/download PDF
38. Low statistics positron activity reconstruction methods for proton therapy.
- Author
-
Muraro, S., Camarlinghi, N., Battistoni, G., Belcari, N., Bisogni, M.G., Cristoforetti, L., Del Guerra, A., Ferrari, A., Fracchiolla, F., Kraan, A., Morrocchi, M., Righetto, R., Sala, P., Schwarz, M., Sportelli, G., Topi, A., and Rosso, V.
- Subjects
- *
PROTON beams , *PROTON therapy , *POSITRON emission tomography , *POSITRONS , *ION beams , *IMAGE reconstruction algorithms , *QUALITY control - Abstract
Positron emission tomography (PET) is one of the most mature techniques for monitoring in ion beam therapy. PET allows to reconstruct the β + activity generated in the patient by the nuclear interaction of the ions. Taking advantage of the spatial correlation between positron emitters created along the ions path and the dose distribution, it is possible to perform a quality control of the treatment. Usually, to reconstruct the activity generated within the irradiated volume, standard 3D PET reconstruction techniques are implemented. In this work, we explore a new reconstruction method (Straight Forward Reconstruction) particularly useful for reconstructing activity distribution generated by mono-energetic pencil beams. The method was validated by measuring the produced activity distribution with the DoPET system. Irradiations performed with mono-energetic pencil beams on phantoms mimicking human tissues were used for this study. Both reconstruction methods reach an accuracy in the reconstruction of the activity distribution width of the order of 1.5 mm for 2 ⋅ 1 0 8 primaries. • PET is one of the most mature techniques for monitoring in ion beam therapy. • A new reconstruction method (Straight Forward Reconstruction) for PET is presented. • Activity distribution and accuracy by pencil beams irradiation are presented. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
39. Particle arc therapy: Status and potential.
- Author
-
Mein S, Wuyckens S, Li X, Both S, Carabe A, Vera MC, Engwall E, Francesco F, Graeff C, Gu W, Hong L, Inaniwa T, Janssens G, de Jong B, Li T, Liang X, Liu G, Lomax A, Mackie T, Mairani A, Mazal A, Nesteruk KP, Paganetti H, Pérez Moreno JM, Schreuder N, Soukup M, Tanaka S, Tessonnier T, Volz L, Zhao L, and Ding X
- Subjects
- Humans, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Intensity-Modulated methods, Heavy Ion Radiotherapy methods, Radiation Oncology, Radiotherapy Dosage, Proton Therapy methods, Neoplasms radiotherapy
- Abstract
There is a rising interest in developing and utilizing arc delivery techniques with charged particle beams, e.g., proton, carbon or other ions, for clinical implementation. In this work, perspectives from the European Society for Radiotherapy and Oncology (ESTRO) 2022 physics workshop on particle arc therapy are reported. This outlook provides an outline and prospective vision for the path forward to clinically deliverable proton, carbon, and other ion arc treatments. Through the collaboration among industry, academic, and clinical research and development, the scientific landscape and outlook for particle arc therapy are presented here to help our community understand the physics, radiobiology, and clinical principles. The work is presented in three main sections: (i) treatment planning, (ii) treatment delivery, and (iii) clinical outlook., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Sophie Wuyckens is funded by the Walloon Region as part of the Arc Proton Therapy convention (Pôles Mecatech et Biowin). Liu Hong and Guillaume Jansens are employed by ION BEAM APPLICATIONS SA (IBA Ltd). Research by Bas De Jong and Stefan Both is partly funded byION BEAM APPLICATIONS SA (IBA Ltd). Thomas Mackie is on the Board and has a financialinterest(stocks) and salary from Leo Cancer Care.Erik Engwall is employed by RaySearch. Martin Soukup is employed by Elekta. Xuanfeng Ding and Xiaoqiang Li have patents related to the particle arc therapy and it has been licensed to IBA. Xuanfeng Ding received honorium from IBA and Elekta’s speaker Bureau and the research project on proton arc therapy is in part supported by IBA and Elekta., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
40. Revision of antifungal strategies definitions for invasive fungal infections (proven/probable/possible) in 461 patients with haematological malignancies (REDEFI-SEIFEM).
- Author
-
Marianna C, Matteo B, Alfonso P, Francesca F, Luisa V, Francesco M, Claudia B, Maria Ilaria DP, Maria Chiara T, Chiara C, Marco P, Valentina B, Nicola F, Anna C, Katia P, Marta S, Anna Rita L, Maurizio S, Alessandro B, and Livio P
- Subjects
- Humans, Prospective Studies, Male, Female, Middle Aged, Adult, Aged, Young Adult, Adolescent, Aged, 80 and over, Hematologic Neoplasms complications, Invasive Fungal Infections drug therapy, Invasive Fungal Infections microbiology, Antifungal Agents therapeutic use
- Abstract
Background: Invasive fungal infections (IFI) are a relevant cause of morbidity and mortality among patients with haematological neoplasms (HMs). Since 2002, a classification of IFI based on host factors, clinical and radiological features and mycological tests was published for research purpose., Objectives: These criteria are widely used in clinical practice to identify patients at risk for IFI. The aim of the study was to evaluate the clinical applicability of EORTC/MSG 2008 criteria for the diagnosis of IFI in daily practice., Patients/methods: This multicentre, non-interventional, observational, prospective study gathered all consecutive inpatients with HMs in which an intravenous antifungal treatment was started. Exclusion criteria were a previous or concomitant transplant procedure, outpatient status and oral antifungal therapy. EORTC/MSG 2008 criteria were used to classify patients at the beginning of antifungal therapy and at 30 days. An independent board reviewed the classification of IFI given by local clinicians at T0 and T30., Results: The highest percentage of agreement was found for possible IFI (96%), while a lower agreement was reported for proven IFI (74%), and the highest variability was observed for probable IFI (56%). At T30, the board re-evaluation confirmed a strict agreement for possible IFI only (98%). Among 306 patients classified as possible, 156 (51%) patients showed non-typical radiological findings and 45 (15%) patients presented host factors only., Conclusions: In real life, the EORTC/MSG criteria can be applicable only for possible IFI. As non-typical radiological findings are reported in possible IFI, introducing a new IFI category should be considered., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
41. Response to "Letter regarding Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy".
- Author
-
Peters N, Taasti VT, Ackermann B, Bolsi A, Dahlgren CV, Ellerbrock M, Fracchiolla F, Gomà C, Góra J, Lopes PC, Rinaldi I, Salvo K, Tarp IS, Vai A, Bortfeld T, Lomax A, Richter C, and Wohlfahrt P
- Subjects
- Humans, Consensus, Tomography, X-Ray Computed, Radiotherapy Planning, Computer-Assisted, Proton Therapy
- Abstract
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
- Published
- 2024
- Full Text
- View/download PDF
42. Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy.
- Author
-
Peters N, Trier Taasti V, Ackermann B, Bolsi A, Vallhagen Dahlgren C, Ellerbrock M, Fracchiolla F, Gomà C, Góra J, Cambraia Lopes P, Rinaldi I, Salvo K, Sojat Tarp I, Vai A, Bortfeld T, Lomax A, Richter C, and Wohlfahrt P
- Subjects
- Humans, Protons, Consensus, Phantoms, Imaging, Tomography, X-Ray Computed methods, Calibration, Proton Therapy methods
- Abstract
Background and Purpose: Studies have shown large variations in stopping-power ratio (SPR) prediction from computed tomography (CT) across European proton centres. To standardise this process, a step-by-step guide on specifying a Hounsfield look-up table (HLUT) is presented here., Materials and Methods: The HLUT specification process is divided into six steps: Phantom setup, CT acquisition, CT number extraction, SPR determination, HLUT specification, and HLUT validation. Appropriate CT phantoms have a head- and body-sized part, with tissue-equivalent inserts in regard to X-ray and proton interactions. CT numbers are extracted from a region-of-interest covering the inner 70% of each insert in-plane and several axial CT slices in scan direction. For optimal HLUT specification, the SPR of phantom inserts is measured in a proton beam and the SPR of tabulated human tissues is computed stoichiometrically at 100 MeV. Including both phantom inserts and tabulated human tissues increases HLUT stability. Piecewise linear regressions are performed between CT numbers and SPRs for four tissue groups (lung, adipose, soft tissue, and bone) and then connected with straight lines. Finally, a thorough but simple validation is performed., Results: The best practices and individual challenges are explained comprehensively for each step. A well-defined strategy for specifying the connection points between the individual line segments of the HLUT is presented. The guide was tested exemplarily on three CT scanners from different vendors, proving its feasibility., Conclusion: The presented step-by-step guide for CT-based HLUT specification with recommendations and examples can contribute to reduce inter-centre variations in SPR prediction., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
43. Proton therapy in the treatment of hepatocellular carcinoma.
- Author
-
Dionisi F, Scartoni D, Fracchiolla F, Giacomelli I, Siniscalchi B, Goanta L, Cianchetti M, Sanguineti G, and Brolese A
- Abstract
Liver cancer represents one of the most common causes of death from cancer worldwide. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancers. Among local therapies, evidence regarding the use of radiation therapy is growing. Proton therapy currently represents the most advanced radiation therapy technique with unique physical properties which fit well with liver irradiation. Here, in this review, we aim to 1) illustrate the rationale for the use of proton therapy (PT) in the treatment of HCC, 2) discuss the technical challenges of advanced PT in this disease, 3) review the major clinical studies regarding the use of PT for HCC, and 4) analyze the potential developments and future directions of PT in this setting., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Dionisi, Scartoni, Fracchiolla, Giacomelli, Siniscalchi, Goanta, Cianchetti, Sanguineti and Brolese.)
- Published
- 2022
- Full Text
- View/download PDF
44. Clinical necessity of multi-image based (4D MIB ) optimization for targets affected by respiratory motion and treated with scanned particle therapy - A comprehensive review.
- Author
-
Knopf AC, Czerska K, Fracchiolla F, Graeff C, Molinelli S, Rinaldi I, Rucincki A, Sterpin E, Stützer K, Trnkova P, Zhang Y, Chang JY, Giap H, Liu W, Schild SE, Simone CB 2nd, Lomax AJ, and Meijers A
- Subjects
- Four-Dimensional Computed Tomography methods, Humans, Motion, Organs at Risk, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted methods, Respiration, Lung Neoplasms, Proton Therapy
- Abstract
4D multi-image-based (4D
MIB ) optimization is a form of robust optimization where different uncertainty scenarios, due to anatomy variations, are considered via multiple image sets (e.g., 4DCT). In this review, we focused on providing an overview of different 4DMIB optimization implementations, introduced various frameworks to evaluate the robustness of scanned particle therapy affected by breathing motion and summarized the existing evidence on the necessity of using 4DMIB optimization clinically. Expected potential benefits of 4DMIB optimization include more robust and/or interplay-effect-resistant doses for the target volume and organs-at-risk for indications affected by anatomical variations (e.g., breathing, peristalsis, etc.). Although considerable literature is available on the research and technical aspects of 4DMIB , clinical studies are rare and often contain methodological limitations, such as, limited patient number, motion amplitude, motion and delivery time structure considerations, number of repeat CTs, etc. Therefore, the data are not conclusive. In addition, multiple studies have found that robust 3D optimized plans result in dose distributions within the set clinical tolerances and, therefore, are suitable for a treatment of moving targets with scanned particle therapy. We, therefore, consider the clinical necessity of 4DMIB optimization, when treating moving targets with scanned particle therapy, as still to be demonstrated., (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)- Published
- 2022
- Full Text
- View/download PDF
45. Technical challenges in the treatment of mediastinal lymphomas by proton pencil beam scanning and deep inspiration breath-hold.
- Author
-
Righetto R, Fracchiolla F, Widesott L, Lorentini S, Dionisi F, Rombi B, Scartoni D, Vennarini S, Schwarz M, and Farace P
- Subjects
- Humans, Organs at Risk, Protons, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted methods, Reproducibility of Results, Lymphoma diagnostic imaging, Lymphoma radiotherapy, Mediastinal Neoplasms diagnostic imaging, Mediastinal Neoplasms radiotherapy, Proton Therapy methods, Radiotherapy, Intensity-Modulated methods
- Abstract
Purpose: To comprehensively describe the treatment of mediastinal lymphoma by pencil beam scanning (PBS) proton therapy., Methods: Fourteen patients underwent PBS proton treatment in a supine position in deep inspiration breath-hold (DIBH). Three DIBH computed tomography (CT) scans were acquired for each patient to delineate the Internal Target Volume (ITV). Intensity-modulated proton therapy (IMPT) was planned by min-max robust optimization on the ITV, with a 6 mm setup and 3.5% range uncertainties. Robustness analysis was performed and dose coverage was visually inspected on the corresponding voxel-wise minimum map. Layer repainting was set equal to 5 to compensate for cardiac motion. Intra-fraction reproducibility during treatment was assessed by repeated daily DIBH X-ray imaging. Finally, an additional CT was acquired at half treatment to estimate the impact of inter-fraction dosimetric reproducibility., Results: IMPT guaranteed robust mediastinal target coverage and organs-at-risk sparing. However, visual voxel-wise robustness evaluation showed that in five patients a second optimization with focused objectives in the cost-function was necessary to achieve a robust coverage of the target regions at the interface between lungs and soft tissue. In six patients, repainting was not used due to excessive treatment time length and poor patient compliance. Intra-fraction average reproducibility was within 1 mm/1degree. On repeated CT scans, inter-fraction setup errors and/or anatomical changes showed minimal dosimetric differences in CTV coverage., Conclusion: IMPT in DIBH is effective and reproducible to treat mediastinal lymphomas. Caution is recommended to guarantee robust dose delivery to high-risk regions at the interface between lungs and soft tissue., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
46. Experimental assessment of inter-centre variation in stopping-power and range prediction in particle therapy.
- Author
-
Peters N, Wohlfahrt P, Dahlgren CV, de Marzi L, Ellerbrock M, Fracchiolla F, Free J, Gomà C, Góra J, Jensen MF, Kajdrowicz T, Mackay R, Molinelli S, Rinaldi I, Rompokos V, Siewert D, van der Tol P, Vermeren X, Nyström H, Lomax A, and Richter C
- Subjects
- Humans, Male, Phantoms, Imaging, Radiotherapy Planning, Computer-Assisted, Tomography, X-Ray Computed, Uncertainty, Proton Therapy
- Abstract
Purpose: Experimental assessment of inter-centre variation and absolute accuracy of stopping-power-ratio (SPR) prediction within 17 particle therapy centres of the European Particle Therapy Network., Material and Methods: A head and body phantom with seventeen tissue-equivalent materials were scanned consecutively at the participating centres using their individual clinical CT scan protocol and translated into SPR with their in-house CT-number-to-SPR conversion. Inter-centre variation and absolute accuracy in SPR prediction were quantified for three tissue groups: lung, soft tissues and bones. The integral effect on range prediction for typical clinical beams traversing different tissues was determined for representative beam paths for the treatment of primary brain tumours as well as lung and prostate cancer., Results: An inter-centre variation in SPR prediction (2σ) of 8.7%, 6.3% and 1.5% relative to water was determined for bone, lung and soft-tissue surrogates in the head setup, respectively. Slightly smaller variations were observed in the body phantom (6.2%, 3.1%, 1.3%). This translated into inter-centre variation of integral range prediction (2σ) of 2.9%, 2.6% and 1.3% for typical beam paths of prostate-, lung- and primary brain-tumour treatments, respectively. The absolute error in range exceeded 2% in every fourth participating centre. The consideration of beam hardening and the execution of an independent HLUT validation had a positive effect, on average., Conclusion: The large inter-centre variations in SPR and range prediction justify the currently clinically used margins accounting for range uncertainty, which are of the same magnitude as the inter-centre variation. This study underlines the necessity of higher standardisation in CT-number-to-SPR conversion., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
47. Clinical validation of a GPU-based Monte Carlo dose engine of a commercial treatment planning system for pencil beam scanning proton therapy.
- Author
-
Fracchiolla F, Engwall E, Janson M, Tamm F, Lorentini S, Fellin F, Bertolini M, Algranati C, Righetto R, Farace P, Amichetti M, and Schwarz M
- Subjects
- Algorithms, Humans, Monte Carlo Method, Phantoms, Imaging, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Proton Therapy
- Abstract
Purpose: To perform the validation of the GPU-based (Graphical Processing Unit based) proton Monte Carlo (MC) dose engine implemented in a commercial TPS (RayStation 10B) and to report final dose calculation times for clinical cases., Materials and Methods: 440 patients treated at the Proton Therapy Center of Trento, Italy, between 2018 and 2019 were selected for this study. 636 approved plans with 3361 beams computed with the clinically implemented CPU-MC dose engine (version 4.2 and 4.5), were used for the validation of the new algorithm. For each beam, the dose was recalculated using the new GPU-MC dose engine with the initial CPU computation settings and compared to the original CPU-MC dose. Beam dose difference distributions were studied to ensure that the two dose distributions were equal within the expected fluctuations of the MC statistical uncertainty (s) of each computation. Plan dose distributions were compared with respect to the dosimetric indices D
98 , D50 and D1 of all ROIs defined as targets. A complete assessment of the computation time as a function of s and dose grid voxel size was done., Results: The median over all mean beam dose differences between CPU- and GPU-MC was -0.01% and the median of the corresponding standard deviations was close to (√2s) both for simulations with an s of 0.5% and 1.0% per beam. This shows that the two dose distributions can be considered equal. All the DVH indices showed an average difference below 0.04%. About half of the plans were computed with 1.0% statistical uncertainty on a 2 mm dose calculation grid, for which the median computation time was 5.2 s. The median computational speed for all plans in the study was 8.4 million protons/second., Conclusion: A validation of a clinical MC algorithm running on GPU was performed on a large pool of patients treated with pencil beam scanning proton therapy. We demonstrated that the differences with the previous CPU-based MC were only due to the intrinsic statistical fluctuations of the MC method, which translated to insignificant differences on plan dose level. The significant increase in dose calculation speed is expected to facilitate new clinical workflows., (Copyright © 2021 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.)- Published
- 2021
- Full Text
- View/download PDF
48. Technical Note: CT calibration for proton treatment planning by cross-calibration with proton CT data.
- Author
-
Farace P, Tommasino F, Righetto R, Fracchiolla F, Scaringella M, Bruzzi M, and Civinini C
- Subjects
- Calibration, Humans, Phantoms, Imaging, Radiotherapy Planning, Computer-Assisted, Tomography, X-Ray Computed, Proton Therapy, Protons
- Abstract
Purpose: This study explores the possibility of a new method for x-ray computed tomography (CT) calibration by means of cross-calibration with proton CT (pCT) data. The proposed method aims at a more accurate conversion of CT Hounsfield Units (HU) into proton stopping power ratio (SPR) relative to water to be used in proton-therapy treatment planning., Methods: X-ray CT scan was acquired on a synthetic anthropomorphic phantom, composed of different tissue equivalent materials (TEMs). A pCT apparatus was instead adopted to obtain a reference three-dimensional distribution of the phantom's SPR values. After rigid registration, the x-ray CT was artificially blurred to the same resolution of pCT. Then a scatter plot showing voxel-by-voxel SPR values as a function of HU was employed to link the two measurements and thus obtaining a cross-calibrated x-ray CT calibration curve. The cross-calibration was tested at treatment planning system and then compared with a conventional calibration based on exactly the same TEMs constituting the anthropomorphic phantom., Results: Cross-calibration provided an accurate SPR mapping, better than by conventional TEMs calibration. The dose distribution of single beams optimized on the reference SPR map was recomputed on cross-calibrated CT, showing, with respect to conventional calibration, minor deviation at the dose fall-off (lower than 1%)., Conclusions: The presented data demonstrated that, by means of reference pCT data, a heterogeneous phantom can be used for CT calibration, paving the way to the use of biological samples, with their accurate description of patients' tissues. This overcomes the limitations of conventional CT calibration requiring homogenous samples, only available by synthetic TEMs, which fail in accurately mimicking the properties of biological tissues. Once a heterogeneous biological sample is provided with its corresponding reference SPR maps, a cross-calibration procedure could be adopted by other PT centers, even when not equipped with a pCT system., (© 2021 American Association of Physicists in Medicine.)
- Published
- 2021
- Full Text
- View/download PDF
49. Clinical results of active scanning proton therapy for primary liver tumors.
- Author
-
Dionisi F, Brolese A, Siniscalchi B, Giacomelli I, Fracchiolla F, Righetto R, Morganti AG, Pravadelli C, Avancini I, Rozzanigo U, Mattiuzzi A, Frisinghelli M, Pertile R, Ciarleglio FA, Vitale A, Schwarz M, and Amichetti M
- Subjects
- Aged, Aged, 80 and over, Disease-Free Survival, Female, Humans, Liver injuries, Liver pathology, Liver Neoplasms epidemiology, Liver Neoplasms pathology, Male, Middle Aged, Radiation Dosage, Radiation Injuries epidemiology, Radiation Injuries etiology, Retrospective Studies, Treatment Outcome, Liver radiation effects, Liver Neoplasms radiotherapy, Proton Therapy adverse effects, Radiation Injuries pathology
- Abstract
Background: Evidence for the efficacy of radiation therapy for primary liver cancer is growing. In this context, proton therapy (PT) can potentially improve the therapeutic ratio, as demonstrated by recent clinical studies. Here we report the first European clinical experience on the use of PT for primary liver cancer., Methods: All patients treated for primary liver cancer in our center entered the analysis. Patients were simulated during deep expiration breath-hold. A 15-fraction treatment schedule was adopted using active scanning PT. Clinical outcome and toxicity were retrospectively analyzed., Results: Between January 2018 and December 2019, 18 patients were treated. Fourteen patients had hepatocellular carcinoma (HCC), three patients had intrahepatic cholangiocarcinoma (ICC), and one patient had synchronous ICC-HCC. The Child-Pugh score was A5 in the majority of patients with HCC (71.4%). Median prescription dose was 58.05 Gy (range, 50.31-67.5). Median follow-up was 10 months (range, 1-19). The majority of deaths occurred from liver tumor progression. One-year overall survival (OS) was 63%. A significant correlation between worse OS and patient performance status, vascular invasion, and tumor stage was recorded. One-year local control was 90%. Toxicity was low, with a decrease in Child-Pugh score ⩾2 points detected in one patient. No cases of classic radiation-induced liver disease occurred., Conclusions: Our initial results of active scanning PT for primary liver cancer demonstrated the feasibility, safety, and effectiveness of this advanced technique in this setting. The potential of the combination of PT with other locoregional therapies is under evaluation.
- Published
- 2021
- Full Text
- View/download PDF
50. Clinical implementation of pencil beam scanning proton therapy for liver cancer with forced deep expiration breath hold.
- Author
-
Fracchiolla F, Dionisi F, Righetto R, Widesott L, Giacomelli I, Cartechini G, Farace P, Bertolini M, Amichetti M, and Schwarz M
- Subjects
- Breath Holding, Humans, Organs at Risk, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Liver Neoplasms radiotherapy, Proton Therapy, Radiotherapy, Intensity-Modulated
- Abstract
Purpose: To present our technique for liver cancer treatments with proton therapy in pencil beam scanning mode and to evaluate the impact of uncertainties on plan quality., Materials and Methods: Seventeen patients affected by liver cancer were included in this study. Patients were imaged and treated in forced breath-hold using the Active Breathing Coordinator system and monitored with an optical tracking system. Three simulation CTs were acquired to estimate the anatomical variability between breath-holds and generate an internal target volume (ITV). The treatment plans were optimized with a Single Field Optimization technique aimed at minimizing the use of range shifter. Plan robustness was tested simulating systematic range and setup uncertainties, as well as the interplay effect between breath-holds. The appropriateness of margin was further verified based on the actual positioning data acquired during treatment., Results: The dose distributions of the nominal plans achieved a satisfactory target coverage in 11 out of 17 patients, while in the remaining 6 D
95 to the PTV was affected by the constraint on mean liver dose. The constraints for all other organs at risk were always within tolerances. The interplay effect had a limited impact on the dose distributions: the worst case scenario showed a D95 reduction in the ITV < 3.9 GyRBE and no OAR with D1 > 105% of the prescription dose. The robustness analysis showed that for 13 out of 17 patients the ITV coverage in terms of D95 was better than D95 of the PTV in the nominal plan. For the remaining 4 patients, the maximum difference between ITV D95 and PTV D95 was ≤0.7% even for the largest simulated setup error and it was deemed clinically acceptable. Hot spots in the OARs were always lower than 105% of the prescription dose. Positioning images confirmed that the breath hold technique and the PTV margin were adequate to compensate for inter- and intra-breath-hold variations in liver position., Conclusion: We designed and clinically applied a technique for the treatment of liver cancer with proton pencil beam scanning in forced deep expiration breath-hold. The initial data on plan robustness and patient positioning suggest that the choices in terms of planning technique and treatment margins are able to reach the desired balance between target coverage and organ at risk sparing., (Copyright © 2020 Elsevier B.V. All rights reserved.)- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.