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1. The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants

Author

Gaston Ofman, Mauricio T. Caballero, Damian Alvarez Paggi, Jacqui Marzec, Florencia Nowogrodzki, Hye-Youn Cho, Mariana Sorgetti, Guillermo Colantonio, Alejandra Bianchi, Luis M. Prudent, Nestor Vain, Gonzalo Mariani, Jorge Digregorio, Elba Lopez Turconi, Cristina Osio, Fernanda Galletti, Mariangeles Quiros, Andrea Brum, Santiago Lopez Garcia, Silvia Garcia, Douglas Bell, Marcus H. Jones, Trent E. Tipple, Steven R. Kleeberger, and Fernando P. Polack

Subjects
Pediatrics, RJ1-570
Abstract

Abstract Background Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with prematurity and infants with BPD suffer from increased incidence of respiratory infections, asthma, other forms of chronic lung illness, and death (Day and Ryan, Pediatr Res 81: 210–213, 2017; Isayama et la., JAMA Pediatr 171:271–279, 2017). BPD is now understood as a longitudinal disease process influenced by the intrauterine environment during gestation and modulated by gene-environment interactions throughout the neonatal and early childhood periods. Despite of this concept, there remains a paucity of multidisciplinary team-based approaches dedicated to the comprehensive study of this complex disease. Methods The Discovery BPD (D-BPD) Program involves a cohort of infants

Published
2019
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2. The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants

Author

Cristina Osio, Gaston Ofman, Gonzalo Mariani, Damian Alvarez Paggi, Mariana Sorgetti, Luis M. Prudent, Fernanda Galletti, Hye-Youn Cho, Elba Lopez Turconi, Andrea C Brum, Jacqui Marzec, Douglas A. Bell, Trent E. Tipple, Marcus Herbert Jones, Florencia Nowogrodzki, Fernando P. Polack, Steven R. Kleeberger, Alejandra Bianchi, Nestor E. Vain, Mauricio T. Caballero, Guillermo Colantonio, Santiago Lopez Garcia, Silvia Garcia, Mariangeles Quiros, and Jorge Digregorio

Subjects
Lung Diseases, Male, Parents, Pediatrics, Disease, Infant, Premature, Diseases, Machine Learning, Translational Research, Biomedical, Study Protocol, Mice, Infant, Very Low Birth Weight, Multicenter Studies as Topic, Early childhood, Prospective Studies, Prospective cohort study, Intersectoral Collaboration, Bronchopulmonary Dysplasia, lcsh:RJ1-570, BPD, purl.org/becyt/ford/3.1 [https], Environmental exposure, Respiratory Function Tests, Premature birth, Cohort, Disease Progression, purl.org/becyt/ford/3 [https], Female, medicine.symptom, Infant, Premature, medicine.medical_specialty, Interdisciplinary Research, Gestational Age, behavioral disciplines and activities, Intensive Care Units, Neonatal, mental disorders, medicine, Animals, Humans, Genetic Predisposition to Disease, Premature, Genetic Association Studies, business.industry, Infant, Newborn, lcsh:Pediatrics, Environmental Exposure, medicine.disease, Low birth weight, Bronchopulmonary dysplasia, Lung disease, Pediatrics, Perinatology and Child Health, Chronic Disease, business, Follow-Up Studies
Abstract

Background: Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with prematurity and infants with BPD suffer from increased incidence of respiratory infections, asthma, other forms of chronic lung illness, and death (Day and Ryan, Pediatr Res 81: 210-213, 2017; Isayama et la., JAMA Pediatr 171:271-279, 2017). BPD is now understood as a longitudinal disease process influenced by the intrauterine environment during gestation and modulated by gene-environment interactions throughout the neonatal and early childhood periods. Despite of this concept, there remains a paucity of multidisciplinary team-based approaches dedicated to the comprehensive study of this complex disease. Methods: The Discovery BPD (D-BPD) Program involves a cohort of infants < 1,250 g at birth prospectively followed until 6 years of age. The program integrates analysis of detailed clinical data by machine learning, genetic susceptibility and molecular translation studies. Discussion: The current gap in understanding BPD as a complex multi-trait spectrum of different disease endotypes will be addressed by a bedside-to-bench and bench-to-bedside approach in the D-BPD program. The D-BPD will provide enhanced understanding of mechanisms, evolution and consequences of lung diseases in preterm infants. The D-BPD program represents a unique opportunity to combine the expertise of biologists, neonatologists, pulmonologists, geneticists and biostatisticians to examine the disease process from multiple perspectives with a singular goal of improving outcomes of premature infants. Trial registration: Does not apply for this study. Fil: Ofman, Gaston. University of Alabama at Birmingahm; Estados Unidos Fil: Caballero, Mauricio Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Álvarez Paggi, Damián Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marzec, Jacqui. National Institute of Environmental Health Sciences; Estados Unidos Fil: Nowogrodzki, Florencia. No especifíca; Fil: Cho, Hye Youn. National Institute of Environmental Health Sciences; Estados Unidos Fil: Sorgetti, Mariana. No especifíca; Fil: Colantonio, Guillermo. No especifíca; Fil: Bianchi, Alejandra. No especifíca; Fil: Prudent, Luis M.. Fundación para la Salud Materno Infantil; Argentina Fil: Vain, Néstor Eduardo. Fundación para la Salud Materno Infantil; Argentina. Sanatorio de la Trinidad Palermo.; Argentina Fil: Mariani, Gonzalo Luis. Hospital Italiano; Argentina Fil: Digregorio, Jorge. Sanatorio de la Trinidad Palermo.; Argentina Fil: Lopez Turconi, Elba. No especifíca; Fil: Osio, Cristina. Sanatorio "Otamendi y Miroli S. A."; Argentina Fil: Galletti, Maria Fernanda. Hospital Italiano; Argentina Fil: Quiros, Mariangeles. Clinica y Maternidad Suizo Argentina; Argentina Fil: Brum, Andrea. Sanatorio de la Trinidad Palermo.; Argentina Fil: Lopez Garcia, Santiago. No especifíca; Fil: Garcia, Silvia. Sanatorio "Otamendi y Miroli S. A."; Argentina Fil: Bell, Douglas. National Institute of Environmental Health Sciences; Estados Unidos Fil: Jones, Marcus H.. Pontificia Universidade Católica do Rio Grande do Sul; Brasil Fil: Tipple, Trent E.. University of Alabama at Birmingahm; Estados Unidos Fil: Kleeberger, Steven R.. National Institute of Environmental Health Sciences; Estados Unidos Fil: Polack, Fernando Pedro. University of Alabama at Birmingahm; Estados Unidos

Published
2019

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