34 results on '"Firth, Mike"'
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2. Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner
3. An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation
4. A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo
5. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
6. Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
7. A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries
8. Delivering Robust Candidates to the Drug Pipeline through Computational Analysis of Arrayed CRISPR Screens
9. Universal toxin-based selection for precise genome engineering in human cells
10. Author Correction: Universal toxin-based selection for precise genome engineering in human cells
11. Rapid target validation in a Cas9-inducible hiPSC derived kidney model
12. High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets
13. CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs
14. In vivo CRISPR editing with no detectable genome-wide off-target mutations
15. BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
16. 11th German Conference on Chemoinformatics (GCC 2015): Fulda, Germany. 8–10 November 2015
17. Engineered Cas9 extracellular vesicles as a novel gene editing tool.
18. Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection
19. Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System.
20. Orthologue chemical space and its influence on target prediction.
21. Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis.
22. Systematic Explorationof Dual-Acting Modulators froma Combined Medicinal Chemistry and Biology Perspective.
23. An incremental, exploratory and transformational environment for lazy functional programming.
24. Formalised development of software by machine assisted transformation.
25. Goods and Services Tax reaches a difficult age.
26. 11th German Conference on Chemoinformatics (GCC 2015)
27. Inbox.
28. COME OUT WRITING.
29. AR in Your Car: How HUDs Are Changing Driving: VIRTUAL DISPLAY TECHNOLOGY PROMISES TO GIVE DRIVERS INSTANT INFORMATION, WHILE IMPROVING DRIVER SAFETY.
30. Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.
31. A Novel Screening Approach for the Dissection of Cellular Regulatory Networks of NF-κB Using Arrayed CRISPR gRNA Libraries.
32. Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity.
33. Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection.
34. Systematic exploration of dual-acting modulators from a combined medicinal chemistry and biology perspective.
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