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1,030 results on '"Fini, Milena"'

5. Assessment of the advantages and limitations of an innovative silk fibroin scaffold for the reconstruction of the anterior cruciate ligament with preclinical in vitro and in vivo evaluations

Author

Giavaresi, Gianluca, Sartori, Maria, Baleani, Massimiliano, Brogini, Silvia, Erani, Paolo, Dallari, Dante, Del Piccolo, Nicolandrea, Ghezzi, Chiara E., Martini, Lucia, Parrilli, Annapaola, Boschi, Alessandra, Tanzi, Maria Cristina, Alessandrino, Antonio, Fini, Milena, Freddi, Giuliano, and Farè, Silvia

Published
2025
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11. A 3D micro‐CT assessment of composition and structure of bone tissue after vertical and horizontal alveolar ridge augmentation using CAD/CAM‐customized titanium mesh.

Author

Cucchi, Alessandro, Marchiori, Gregorio, Sartori, Maria, Fini, Milena, Fiorino, Antonino, Donati, Raffaele, Corinaldesi, Giuseppe, and Maglio, Melania

Subjects
BONE density, ALVEOLAR process, BONE grafting, BONE regeneration, CANCELLOUS bone
Abstract

Objectives: To date, no studies have exploited micro‐CT in humans to evaluate bone morphology and structure after bone augmentation with CAD/CAM‐customized titanium mesh, in mandible and maxilla. The aim of this study was to assess the composition and microstructure of bone biopsy through micro‐CT analysis. Materials and Methods: Bone augmentation at both maxillary and mandible sites was performed on 30 patients randomly treated with customized mesh, either alone (M−) or covered with resorbable membrane (M+), in both cases filled 50:50 with autogenous bone and xenograft. After 6 months, biopsies were taken and micro‐CT was performed on consecutive 1‐mm‐thick VOIs from coronal to apical side, measuring tissue volumes, trabecular thickness, spacing, and number. Results: In both groups, irrespective of membrane use, bone tissue (M−: 29.76% vs. M+: 30.84%) and residual graft material (M−: 14.87% vs. M+: 13.11%) values were similar. Differences were site‐related (maxillary vs. mandibular) with higher percentage of bone tissue and trabecular density of low‐mineralized bone and overall bone in the mandible. Conclusions: The composition and structure of bone tissue, as assessed by micro‐CT after alveolar ridge augmentation using CAD/CAM‐customized titanium meshes, showed similar features regardless of whether a collagen membrane was applied. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Platelet and Lymphocyte-Related Parameters as Potential Markers of Osteoarthritis Severity: A Cross-Sectional Study.

Author

Salamanna, Francesca, Pagani, Stefania, Filardo, Giuseppe, Contartese, Deyanira, Boffa, Angelo, Angelelli, Lucia, Maglio, Melania, Fini, Milena, Zaffagnini, Stefano, and Giavaresi, Gianluca

Subjects
MEAN platelet volume, PLATELET count, PLATELET lymphocyte ratio, LYMPHOCYTE count, BODY mass index
Abstract

Background: Platelets and lymphocytes levels are important in assessing systemic disorders, reflecting inflammatory and immune responses. This study investigated the relationship between blood parameters (platelet count (PLT), mean platelet volume (MPV), lymphocyte count (LINF), and platelet-to-lymphocyte ratio (PLR)) and osteoarthritis (OA) severity, considering age, sex, and body mass index (BMI). Methods: Patients aged ≥40 years were included in this cross-sectional study and divided into groups based on knee OA severity using the Kellgren–Lawrence (KL) grading system. A logistic regression model, adjusted for confounders, evaluated the ability of PLT, MPV, LINF, and PLR to categorize OA severity. Model performance in terms of accuracy, sensitivity, and specificity was assessed using ROC curves. Results: The study involved 245 OA patients (51.4% female, 48.6% male) aged 40–90 years, 35.9% with early OA (KL < 3) and 64.1% moderate/severe OA (KL ≥ 3). Most patients (60.8%) were aged ≥60 years, and BMI was <25 kg/m2 in 33.9%. The model showed that a 25-unit increase in PLR elevates the odds of higher OA levels by 1.30 times (1-unit OR = 1.011, 95% CI [1.004, 1.017], p < 0.005), while being ≥40 years old elevates the odds by 4.42 times (OR 4.42, 95% CI [2.46, 7.95], p < 0.0005). The model's accuracy was 73.1%, with 84% sensitivity, 52% specificity, and an AUC of 0.74 (95% CI [0.675, 0.805]). Conclusions: Higher PLR increases the likelihood of moderate/severe OA, suggesting that monitoring these biomarkers could aid in early detection and management of OA severity. Further research is warranted to cross-validate these results in larger populations. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Preliminary Evaluation of Bioactive Collagen–Polyphenol Surface Nanolayers on Titanium Implants: An X-ray Photoelectron Spectroscopy and Bone Implant Study.

Author

Morra, Marco, Iviglia, Giorgio, Cassinelli, Clara, Sartori, Maria, Cavazza, Luca, Martini, Lucia, Fini, Milena, and Giavaresi, Gianluca

Subjects
X-ray photoelectron spectroscopy, DENTAL implants, BONE regeneration, OSSEOINTEGRATION, SURFACE properties
Abstract

To endow an implant surface with enhanced properties to ensure an appropriate seal with the host tissue for inflammation/infection resistance, next-generation bone implant collagen–polyphenol nanolayers were built on conventional titanium surfaces through a multilayer approach. X-ray Photoelectron Spectroscopy (XPS) analysis was performed to investigate the chemical arrangement of molecules within the surface layer and to provide an estimate of their thickness. A short-term (2 and 4 weeks) in vivo test of bone implants in a healthy rabbit model was performed to check possible side effects of the soft surface layer on early phases of osteointegration, leading to secondary stability. Results show the building up of the different nanolayers on top of titanium, resulting in a final composite collagen–polyphenol surface and a layer thickness of about 10 nm. In vivo tests performed on machined and state-of-the-art microrough titanium implants do not show significant differences between coated and uncoated samples, as the surface microroughness remains the main driver of bone-to-implant contact. These results confirm that the surface nanolayer does not interfere with the onset and progression of implant osteointegration and prompt the green light for specific investigations of the potential merits of this bioactive coating as an enhancer of the device/tissue seal. [ABSTRACT FROM AUTHOR]

Published
2024
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37. A Pilot Study on Circulating, Cellular, and Tissue Biomarkers in Osteosarcopenic Patients.

Author

Salamanna, Francesca, Faldini, Cesare, Veronesi, Francesca, Borsari, Veronica, Ruffilli, Alberto, Manzetti, Marco, Viroli, Giovanni, Traversari, Matteo, Marchese, Laura, Fini, Milena, and Giavaresi, Gianluca

Subjects
BIOMARKERS, FISHER discriminant analysis, PILOT projects, MUSCLE mass
Abstract

Aging comes with the loss of muscle and bone mass, leading to a condition known as osteosarcopenia. Circulating, cellular, and tissue biomarkers research for osteosarcopenia is relatively scarce and, currently, no established biomarkers exist. Here we find that osteosarcopenic patients exhibited elevated basophils and TNFα levels, along with decreased aPPT, PT/INR, IL15, alpha-Klotho, DHEA-S, and FGF-2 expression and distinctive bone and muscle tissue micro-architecture and biomarker expressions. They also displayed an increase in osteoclast precursors with a concomitant imbalance towards spontaneous osteoclastogenesis. Similarities were noted with osteopenic and sarcopenic patients, including a lower neutrophil percentage and altered cytokine expression. A linear discriminant analysis (LDA) on models based on selected biomarkers showed a classification accuracy in the range of 61–78%. Collectively, our data provide compelling evidence for novel biomarkers for osteosarcopenia that may hold potential as diagnostic tools to promote healthy aging. [ABSTRACT FROM AUTHOR]

Published
2024
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38. An Advanced Human Bone Tissue Culture Model for the Assessment of Implant Osteointegration In Vitro.

Author

Maglio, Melania, Fini, Milena, Sartori, Maria, Codispoti, Giorgia, Borsari, Veronica, Dallari, Dante, Ambretti, Simone, Rocchi, Martina, and Tschon, Matilde

Subjects
*TISSUE culture, *OSSEOINTEGRATION, *PLASTIC surgery, *CANCELLOUS bone, *TOTAL hip replacement, *COPPER
Abstract

In the field of biomaterials for prosthetic reconstructive surgery, there is the lack of advanced innovative methods to investigate the potentialities of smart biomaterials before in vivo tests. Despite the complex osteointegration process being difficult to recreate in vitro, this study proposes an advanced in vitro tissue culture model of osteointegration using human bone. Cubic samples of trabecular bone were harvested, as waste material, from hip arthroplasty; inner cylindrical defects were created and assigned to the following groups: (1) empty defects (CTRneg); (2) defects implanted with a cytotoxic copper pin (CTRpos); (3) defects implanted with standard titanium pins (Ti). Tissues were dynamically cultured in mini rotating bioreactors and assessed weekly for viability and sterility. After 8 weeks, immunoenzymatic, microtomographic, histological, and histomorphometric analyses were performed. The model was able to simulate the effects of implantation of the materials, showing a drop in viability in CTR+, while Ti appears to have a trophic effect on bone. MicroCT and a histological analysis supported the results, with signs of matrix and bone deposition at the Ti implant site. Data suggest the reliability of the tested model in recreating the osteointegration process in vitro with the aim of reducing and refining in vivo preclinical models. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Osseointegration is improved by coating titanium implants with a nanostructured thin film with titanium carbide and titanium oxides clustered around graphitic carbon

Author

Veronesi, Francesca, Giavaresi, Gianluca, Fini, Milena, Longo, Giovanni, Ioannidu, Caterina Alexandra, Scotto d'Abusco, Anna, Superti, Fabiana, Panzini, Gianluca, Misiano, Carlo, Palattella, Alberto, Selleri, Paolo, Di Girolamo, Nicola, Garbarino, Viola, Politi, Laura, and Scandurra, Roberto

Published
2017
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