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Objectives To examine the relationships between pre-pregnancy diabetes mellitus (DM), gestational diabetes mellitus (GDM), pre-pregnancy body mass index (BMI) and county-level social determinants of health, with infant macrosomia within a sample of American Indian/Alaska Native (AI/AN) women receiving Indian Health Service (IHS) care. Methods The sample included women-infant dyads representing 1,136 singleton births from fiscal year 2011 (10/1/2019-9/30/2011). Data stemmed from the IHS Improving Health Care Delivery Data Project. Multivariate generalized linear mixed models were fitted to assess the association of macrosomia with pre-pregnancy health status and social determinants of health. Results Nearly half of the women in the sample were under age 25 years (48.6%), and most had Medicaid health insurance coverage (76.7%). Of those with a pre-pregnancy BMI measure, 66.2% were overweight or obese. Although few women had pre-pregnancy DM (4.0%), GDM was present in 12.8% of women. Most women had a normal term delivery (85.4%). Overweight, obesity, pre-pregnancy DM, and county-level rurality were all significantly associated with higher odds of infant macrosomia., Author(s): Vanessa Y. Hiratsuka [sup.1] [sup.2] , Margaret Reid [sup.3] , Jenny Chang [sup.4] , Luohua Jiang [sup.5] , Angela G. Brega [sup.6] , Amber L. Fyfe-Johnson [sup.7] , Kimberly [...]

Among infants born to mothers with gestational diabetes mellitus (GDM) who were obese before pregnancy, macrosomia is positively related to maternal weight before pregnancy and maternal blood glucose levels measured [...]