1. Multispecies Outbreak of Nocardia Infections in Heart Transplant Recipients and Association with Climate Conditions, Australia
- Author
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Jonathan Li, Cindy Lau, Naomi Anderson, Fay Burrows, Feras Mirdad, Lilibeth Carlos, Andrew J. Pitman, Kavitha Muthiah, David R. Darley, David Andresen, Peter Macdonald, Deborah Marriott, and Nila J. Dharan
- Subjects
Nocardia ,immunocompromised host ,organ transplantation ,disease outbreak ,climate ,Australia ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
A multispecies outbreak of Nocardia occurred among heart transplant recipients (HTR), but not lung transplant recipients (LTR), in Sydney, New South Wales, Australia, during 2018–2019. We performed a retrospective review of 23 HTR and LTR who had Nocardia spp. infections during June 2015–March 2021, compared risk factors for Nocardia infection, and evaluated climate conditions before, during, and after the period of the 2018–2019 outbreak. Compared with LTR, HTR had a shorter median time from transplant to Nocardia diagnosis, higher prevalence of diabetes, greater use of induction immunosuppression with basiliximab, and increased rates of cellular rejection before Nocardia diagnosis. During the outbreak, Sydney experienced the lowest monthly precipitation and driest surface levels compared with time periods directly before and after the outbreak. Increased immunosuppression of HTR compared with LTR, coupled with extreme weather conditions during 2018–2019, may explain this outbreak of Nocardia infections in HTR.
- Published
- 2022
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