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The possible geometric structures, relative stability, electronic, magnetic properties and spectral properties of GanAg (n = 1–7) clusters are investigated with the density functional method at B3LYP/LanL2DZ level. The calculations indicated that the doped silver atom can't alter the ground state structure of pure gallium. Ga5Ag and Ga7Ag keep higher stabilities when compared with the other clusters. Doping the Ga clusters by Ag atom decreases the total chemical stability of these structures, and causes a shift in electron density toward the Ag atom. The total magnetic moments and the local magnetic moments of Ga and Ag atoms present an even-odd oscillation. The Ga5Ag and Ga7Ag exhibit better infrared and Raman activity in the respective band and an obvious resonance phenomenon is found. [ABSTRACT FROM AUTHOR]

Stroke is a major public health concern. The lack of effective therapies heightens the need for new therapeutic targets. Mammalian brain has the ability to rewire itself to restore lost functionalities. Promoting regenerative repair, including neurogenesis and dendritic remodeling, may offer a new therapeutic strategy for the treatment of stroke. Here, we report that interaction of neuronal nitric oxide synthase (nNOS) with the protein postsynaptic density-95 (PSD-95) negatively controls regenerative repair after stroke in rats. Dissociating nNOS-PSD-95 coupling in neurons promotes neuronal differentiation of neural stem cells (NSCs), facilitates the migration of newborn cells into the injured area, and enhances neurite growth of newborn neurons and dendritic spine formation of mature neurons in the ischemic brain of rats. More importantly, blocking nNOS-PSD-95 binding during the recovery stage improves stroke outcome via the promotion of regenerative repair in rats. Histone deacetylase 2 in NSCs may mediate the role of nNOS-PSD-95 association. Thus, nNOS-PSD-95 can serve as a target for regenerative repair after stroke. [ABSTRACT FROM AUTHOR]

To investigate the prevalence of active transport (AT, defined as walking or bicycling for transport) and to explore the association between AT and health outcomes, we conducted a population-based cross-sectional study in Jiangsu, China, where walking and bicycling are still the main modes of transport. In this study, 8400 community residents aged 18 or above were interviewed following a multistage random sampling method (100% response rate). Face-to-face questionnaire survey data, anthropometric measurements, and biochemical data from blood tests were collected. Results show that 49.6% of the subjects, as part of daily transport, actively traveled on average 5.3 days per week, 53.5 minutes per day, and 300.3 minutes per week. There was an inverse correlation betweenAT and some health outcomes:AT respondents had a higher prevalence of cholesterol disorder;AT respondents who actively travelled every day had a higher risk of diabetes, whilst AT respondents with shorter daily or weekly duration had a lower risk of obesity, central obesity, and cholesterol disorder. Moreover, AT influences more health aspects among urban residents than among rural residents. Findings of this study do not support the notion that AT is beneficial to population health. Further research is needed in determining the negative side effects of AT. [ABSTRACT FROM AUTHOR]

For an immersed submanifold x: M m → S n in the unit sphere S n without umbilics, an eigenvalue of the Blaschke tensor of x is called a Blaschke eigenvalue of x. It is interesting to determine all hypersurfaces in S n with constant Blaschke eigenvalues. In this paper, we are able to classify all immersed hypersurfaces in S m+1 with vanishing Möbius form and constant Blaschke eigenvalues, in case (1) x has exact two distinct Blaschke eigenvalues, or (2) m = 3. With these classifications, some interesting examples are also presented. [ABSTRACT FROM AUTHOR]