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366 results on '"Fei, Weidong"'

23. Nanotherapeutics for hydrogen sulfide-involved treatment: An emerging approach for cancer therapy

Author

Fan Xiaoyu, Fei Weidong, Zhang Meng, Yang Shan, Zhao Mengdan, and Zheng Caihong

Subjects
hydrogen sulfide, nanotherapeutics, cancer, therapy, properties, Technology, Chemical technology, TP1-1185, Physical and theoretical chemistry, QD450-801
Abstract

Hydrogen sulfide (H2S), as the third gasotransmitter, plays important roles in promoting the growth, proliferation, and metastasis of cancer cells. Recently, emerging nanotherapeutics have been developed for cancer therapy by regulating the H2S concentration at tumor sites. The action of H2S in cancer therapy can be demonstrated by a bell-shaped dose-response curve. In addition to the H2S donation from gas therapy, reducing the level of intratumoral H2S can also exert an antitumor effect by disturbing the redox balance of tumor cells. On top of that, the integration of nanotechnology further enhances the diversity of H2S-involved cancer treatments. As a result, phototherapy, chemotherapy, immunotherapy, and ultrasonic therapy can all be realized by designing nanotherapeutics based on the physicochemical properties of H2S. Furthermore, the active/passive targeting effects and onsite H2S-regulating ability of nanotherapeutics greatly improve the safety of treatment. To track the development and promote the clinical transformation of H2S-involved nanotherapeutics, this review introduced the antitumor-related properties of H2S gas and the evolution of H2S-involved cancer therapy. Then, we discussed the design concepts and mechanisms of H2S-involved nanotherapeutics in depth. Finally, the future expectations and challenges were spotlighted in the concept of translational medicine.

Published
2022
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25. Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis.

Author

Peng, Yujie, Zhang, Meng, Yan, Jingjing, Wang, Rong, Xin, Yu, Zheng, Xiaoling, Zhu, Libo, Fei, Weidong, and Zhao, Mengdan

Abstract

Endometriosis and adenomyosis are debilitating gynecological conditions that severely affect the quality of life of women. Traditional diagnostic and treatment methods, including laparoscopic surgery and hormonal therapy, face significant limitations such as incomplete lesion detection, high recurrence rates, and adverse side effects. Emerging bioengineering technologies offer promising solutions for precise diagnosis and therapy of these diseases. Advances in biomarker detection through electrochemical immunosensors, including specific molecular markers like cytokines and growth factors, have improved their early diagnosis. Innovative imaging techniques, such as near-infrared fluorescence imaging, magnetic resonance imaging, and photoacoustic imaging, enhance lesion visualization and surgical precision. In therapeutic applications, bioengineered drug delivery systems enable targeted therapy by modifying drug carriers with ligands targeting highly expressed receptors in endometriotic lesions. Such strategies could improve drug accumulation at target sites and reduce damage to healthy tissues. Integrating external energy (including lasers, focused ultrasound, and magnetic fields) with nanoplatforms offers key benefits for treating endometriosis and adenomyosis, allowing precise delivery of energy-responsive molecules to lesions and minimizing damage to healthy tissues. Additionally, novel approaches, such as immunotherapy, gene therapy, ferroptosis induction, and synthetic lethal activation, offer new avenues for effective treatment of endometriosis and adenomyosis. Significantly, this paper discusses the advantages of precision diagnosis and treatment of endometriosis in preserving the fertility of women of reproductive age. This review highlights the potential of bioengineering breakthroughs to transform the diagnosis and management of endometriosis and adenomyosis, emphasizing their role in advancing precision medicine and improving women's health. [ABSTRACT FROM AUTHOR]

Published
2025
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