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EgeUn###, This study, subphthalocyanines (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc-TiO2) were synthesized as novel photosensitizers. Their PDT effects were evaluated. Furthermore, nuclear imaging potential of 131I-labelled SubPc/SubPc-TiO2 were examined in mouse mammary carcinoma (EMT6) and cervix adenocarcinoma (HeLa) cell lines. The uptake results show that SubPc labelled with 131I radionuclide (131I-SubPc) in EMT6 and HeLa cell lines was found to be approximately the same as in the WI38 cell line. However, the uptake values of SubPc-TiO2 labelled with 131I (131I-SubPc-TiO2) in EMT6 and HeLa cell lines were determined to be two times higher than in the WI38 cell line. In other words, the target/non-target tissue ratio was identified as two in the EMT6 and HeLa cell lines. 131I-SubPc-TiO2 is promising for imaging or treatment of breast and cervix tumors. In vitro photodynamic therapy studies have shown that SubPc and SubPc-TiO2 are suitable agents for PDT. In addition, SubPc-TiO2 has higher phototoxicity than SubPc. As a future study, in vivo experiments will be held and performed in tumor-bearing nude mice. © 2019 World Scientific Publishing Company., Mersin Üniversitesi Ege Üniversitesi TR33400 114Z430, aDepartment of Nuclear Applications, Institute of Nuclear Science, Ege University, Bornova, 35100, Izmir, Turkey bDepartment of Energy Systems Engineering, Faculty of Technology, Tarsus University, TR33400, Tarsus, Turkey cDepartment of Biomedical Technology, Institute of Science, Ege University, Bornova, 35100, Izmir, Turkey dDepartment of Medical Biology, Faculty of Medicine, Ege University, Bornova, 35100, Izmir, Turkey eAdvanced Technology Research & Application Center, Mersin University, Ciftlikkoy Campus, TR33343, Yenisehir, Mersin, Turkey -- The authors gratefully acknowledge financial support by The Scientific and Technological Research Council of Turkey, TUBITAK (Grant no: 114Z430).