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This study considers a risk-averse manufacturer that invests in sustainability technology to reduce carbon emissions under a cap-and-trade policy. In this study, stochastic demand is initially modeled as a linear function of both the sales price and sustainability level. Employing the newsvendor model framework, the objective of the risk-averse manufacturer is assessed using a mean-variance approach. By analyzing serval optimal properties of the joint operational decisions, this study provides the closed-form solutions of the sales price and sustainability level. This study further provides several numerical examples to illustrate the theoretical results and investigates the impacts of the major parameter on the operations of the risk-averse manufacturer.

Summary: Background: Hospitals in China are classified into tiers (1, 2 or 3), with the largest (tier 3) having more equipment and specialist staff. Differential health insurance cost-sharing by hospital tier (lower deductibles and higher reimbursement rates in lower tiers) was introduced to reduce overcrowding in higher tier hospitals, promote use of lower tier hospitals, and limit escalating healthcare costs. However, little is known about the effects of differential cost-sharing in health insurance schemes on choice of hospital tiers. Methods: In a 9-year follow-up of a prospective study of 0.5 M adults from 10 areas in China, we examined the associations between differential health insurance cost-sharing and choice of hospital tiers for patients with a first hospitalisation for stroke or ischaemic heart disease (IHD) in 2009–2017. Analyses were performed separately in urban areas (stroke: n = 20,302; IHD: n = 19,283) and rural areas (stroke: n = 21,130; IHD: n = 17,890), using conditional logit models and adjusting for individual socioeconomic and health characteristics. Findings: About 64–68% of stroke and IHD cases in urban areas and 27–29% in rural areas chose tier 3 hospitals. In urban areas, higher reimbursement rates in each tier and lower tier 3 deductibles were associated with a greater likelihood of choosing their respective hospital tiers. In rural areas, the effects of cost-sharing were modest, suggesting a greater contribution of other factors. Higher socioeconomic status and greater disease severity were associated with a greater likelihood of seeking care in higher tier hospitals in urban and rural areas. Interpretation: Patient choice of hospital tiers for treatment of stroke and IHD in China was influenced by differential cost-sharing in urban areas, but not in rural areas. Further strategies are required to incentivise appropriate health seeking behaviour and promote more efficient hospital use. Funding: Wellcome Trust, Medical Research Council, British Heart Foundation, Cancer Research UK, Kadoorie Charitable Foundation, China Ministry of Science and Technology, and National Natural Science Foundation of China.

AbstractWe present the results of a magnetotelluric (MT) array across the Qilian orogenic belt to elucidate the uplift mechanism of the northeastern Tibetan Plateau (Qinghai-Tibet Plateau). The array extends from the Qaidam basin in the south to the southern edge of the Alxa block in the north. Using the three-dimensional (3D) inversion of MT data based on unstructured tetrahedral elements, the electrical structure 100 km below the orogenic belt is obtained. The results show that there are high-resistivity bodies in the lithospheric mantle of the North Qilian and Hexi Corridor, which may represent the trace of southward subduction of the Asian lithosphere. Besides, there are partially molten bodies with low resistivity in the middle and lower crust below the Qilian orogenic belt, which may be caused by tectonic heat. The melt fraction of low-resistivity bodies is 2-5%, which indicates that the crustal flow from the Qiangtang and Songpan-Ganzi blocks is unable to penetrate beneath the Qilian orogenic belt. The low-resistivity bodies beneath the Qilian orogenic belt decouples the upper crust from the middle-lower crust. Owing to the continuous compression, the decoupled middle-lower crust has subsequently driven the northward movement of the upper crust, resulting in the uplift of the Qilian orogenic belt.

Abstract Background Nocturnal symptoms in Parkinson’s disease are often treated after management of daytime manifestations. In order to better understand the unmet needs of nocturnal symptoms management, we analyzed the characteristics and burden of nocturnal symptoms from patients’ perspectives and explored their changes over time. Overall symptoms (occurring at day or night) were collected to compare whether the unmet needs related to nocturnal symptoms and to overall symptoms are different. Methods We used a Social Listening big-data technique to analyze large amounts of Parkinson’s disease symptoms in dialogues available from social media platforms in 2016 to 2018. These symptoms were classified as either overall symptoms or nocturnal symptoms. We used share of voice (SOV) of symptoms as a proportion of total dialogues per year to reflect the characteristics of symptoms. Negative sentiment score of symptoms was analyzed to find out their related burden. Results We found the SOV for overall motor symptoms was 79% and had not increased between 2016 and 2018 (79%, p = 0.5). The SOV for non-motor symptoms was 69% and had grown by 7% in 2018 (p

Abstract Background Few studies in China have examined personal ultraviolet radiation (UVR) exposure using polysulfone dosimetry. Methods In this study, 93 mother and adolescent child pairs (N = 186) from two locations in China, one rural (higher latitude) and one urban (lower latitude), completed 3 days of personal UVR dosimetry and a sun/clothing diary, as part of a larger pilot study. Results The average daily ambient UVR in each location as measured by dosimetry was 20.24 Minimal Erythemal Doses (MED) in the rural location and 20.53 MED in the urban location. Rural mothers had more average daily time outdoors than urban mothers (5.5 h, compared with 1.5 h, in urban mothers) and a much higher daily average personal UVR exposure (4.50 MED, compared with 0.78 MED in urban mothers). Amongst adolescents, rural males had the highest average daily personal UVR exposure, followed by rural females, urban females and urban males (average 2.16, 1.05, 0.81, and 0.48 MED, respectively). Conclusions Although based on small numbers, our findings show the importance of geographic location, age, work/school responsibilities, and sex of the adolescents in determining personal UVR exposure in China. These results suggest that latitude of residence may not be a good proxy for personal UVR exposure in all circumstances.

Summary: Background: Stroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis and treatment, little is known about the short-term and long-term prognosis after a first stroke in low-income and middle-income countries, including China. We aimed to assess the short-term and long-term risk of recurrent stroke and mortality after a first stroke for each of the major pathological stroke types. Methods: This population-based cohort study included adults aged 35–74 years without disability who were recruited to the China Kadoorie Biobank (CKB). A baseline survey was conducted in ten geographical areas (five urban, five rural) in China, and participants had clinical measurements recorded. Participants were followed up by monitoring death registries and by electronic linkage to health registries and health insurance claims databases, with follow-up until Jan 1, 2017. Participants were excluded from analyses if they had a previous history of stroke, transient ischaemic attack, or ischaemic heart disease at baseline. All incidences of fatal and non-fatal stroke during the study period were recorded by type (ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and unspecified type). Primary outcome measures were 28-day mortality, recurrent stroke, major vascular events (recurrent stroke, myocardial infarction, or vascular death), vascular mortality, and all-cause mortality. Findings: Of 512 715 individuals in the CKB, 489 586 participants without previous ischaemic heart disease and stroke at recruitment were included, of whom 45 732 (42 073 [92%] confirmed by brain imaging) had a stroke during the study period. The mean age was 59·3 years (SD 9·8) for participants who had a stroke (54% women) and 50·8 years (10·3) for participants with no stroke (60% women). 36 588 (80%) of the incident cases of stroke were ischaemic stroke, 7440 (16%) were intracerebral haemorrhage, 702 (2%) were subarachnoid haemorrhage, and 1002 (2%) were an unspecified stroke type. 28-day mortality was 3% (95% CI 3–4) for ischaemic stroke, 47% (46–48)for intracerebral haemorrhage, 19% (17–22; 52% for rural areas and 32% for urban areas) subarachnoid haemorrhage, and 24% (22–27) for unspecified stroke. Among participants who survived stroke at 28 days, 41% (41–42) had recurrent stroke at 5 years (ischaemic stroke 41% [41–42], intracerebral haemorrhage 44% [42–46], subarachnoid haemorrhage 22% [18–27], unspecified stroke type 40% [35–44]) and mortality at 5 years was 17% ([17–18] ischaemic stroke 16% [15–16], intracerebral haemorrhage 28% [26–29], subarachnoid haemorrhage 16% [12–20], unspecified stroke type 15% [12–19]). After a first ischaemic stroke, 91% of recurrent strokes were also ischaemic stroke; after an intracerebral haemorrhage, 56% of recurrent strokes were intracerebral haemorrhage, and 41% of recurrent strokes were ischaemic stroke. Interpretation: After a first stroke, the risk of recurrence or death within 5 years was high among this population of Chinese adults. Urgent improvements to secondary prevention of stroke in China are needed to reduce these risks. Funding: Wellcome Trust, Medical Research Council, British Heart Foundation, Cancer Research UK, Kadoorie Charitable Foundation, Chinese Ministry of Science and Technology, National Natural Science Foundation of China. Copyright: © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Summary: Background: Cooking practice has transitioned from use of solid fuels to use of clean fuels, with addition of better ventilation facilities. However, the change in mortality risk associated with such a transition remains unclear. Methods: The China Kadoorie Biobank (CKB) Study enrolled participants (aged 30–79 years) from ten areas across China; we chose to study participants from five urban areas where transition from use of solid fuels to clean fuels for cooking was prevalent. Participants who reported regular cooking (weekly or more frequently) at baseline were categorised as persistent clean fuel users, previous solid fuel users, or persistent solid fuel users, according to self-reported fuel use histories. All-cause and cardiopulmonary mortality were identified through linkage to China's Disease Surveillance Point system and local mortality records. Findings: Between June 24, 2004, and July 15, 2008, 226 186 participants living in five urban areas of China were enrolled in the CKB Study. Among 171 677 participants who reported cooking regularly (weekly or more frequently), 75 785 (44%) were persistent clean fuel users, 80 511 (47%) were previous solid fuel users, and 15 381 (9%) were persistent solid fuel users. During a mean of 9·8 (SD 1·7) years of follow-up, 10 831 deaths were documented, including 3819 cardiovascular deaths and 761 respiratory deaths. Compared with persistent clean fuel users, persistent solid fuel users had significantly higher risks of all-cause mortality (hazard ratio [HR] 1·19, 95% CI 1·10–1·28), cardiovascular mortality (1·24, 1·10–1·39), and respiratory mortality (1·43, 1·10–1·85). The excess risk of all-cause and cardiopulmonary mortality fell by more than 60% in 5 years after cessation of solid fuel use and continued to decrease afterwards. Use of ventilation was associated with lower all-cause mortality risk, even among persistent clean fuel users (HR 0·78, 0·69–0·89). Interpretation: Solid fuel use for cooking is associated with a higher risk of mortality, and cessation of solid fuel use cuts excess mortality risks swiftly and substantially within 5 years. Ventilation use also lowers the risk of mortality, even among people who persistently use clean fuels. It is of prime importance for both policy makers and the public to accelerate the transition from solid fuels to clean fuels and promote efficient ventilation to minimise further adverse health effects. Funding: National Natural Science Foundation of China, Wellcome Trust, and Kadoorie Charitable Foundation.

A few prospective studies have suggested that tea, alcohol, and fruit consumption may reduce the risk of kidney stones. However, little is known whether such associations and their combined effect persist in Chinese adults, for whom the popular tea and alcohol drinks are different from those investigated in the aforementioned studies. The present study included 502,621 participants from the China Kadoorie Biobank (CKB). Information about tea, alcohol, and fruit consumption was self-reported at baseline. The first documented cases of kidney stones during follow-up were collected through linkage with the national health insurance system. Cox regression was used to calculate the hazard ratio (HR) and 95% confidence interval (CI). During a median of 11.1 years of follow-up, we collected 12,407 cases of kidney stones. After multivariable adjustment, tea, alcohol, and fruit consumption were found to be negatively associated with kidney stone risk, but the linear trend was only found in tea and fruit consumption. Compared with non-tea consumers, the HR (95% CI) for participants who drank ≥7 cups of tea per day was 0.73 (0.65–0.83). Compared with non-alcohol consumers, the HR (95% CI) was 0.79 (0.72–0.87) for participants who drank pure alcohol of 30.0–59.9 g per day but had no further decrease with a higher intake of alcohol. Compared with less-than-weekly consumers, the HR (95% CI) for daily fruit consumers was 0.81 (0.75–0.87). Even for those who did not drink alcohol excessively, increasing tea and fruit consumption could also independently reduce the stone risk. Among Chinese adults, tea, alcohol, and fruit consumption was associated with a lower risk of kidney stones.

Clinicians often encounter thyroid function tests (TFT) comprising serum/plasma free thyroxine (FT4) and thyroid stimulating hormone (TSH) measured using different assay platforms during the course of follow-up evaluations which complicates reliable comparison and interpretation of TFT changes. Although interconversion between concentration units is straightforward, the validity of interconversion of FT4/TSH values from one assay platform to another with different reference intervals remains questionable. This study aims to establish an accurate and reliable methodology of interconverting FT4 by any laboratory to an equivalent FT4 value scaled to a reference range of interest via linear transformation methods. As a proof-of-concept, FT4 was simultaneously assayed by direct analog immunoassay, tandem mass spectrometry and equilibrium dialysis. Both linear and piecewise linear transformations proved relatively accurate for FT4 inter-scale conversion. Linear transformation performs better when FT4 are converted from a more accurate to a less accurate assay platform. The converse is true, whereby piecewise linear transformation is superior to linear transformation when converting values from a less accurate method to a more robust assay platform. Such transformations can potentially apply to other biochemical analytes scale conversions, including TSH. This aids interpretation of TFT trends while monitoring the treatment of patients with thyroid disorders.

The Huailai area is rich in geothermal resources, but the formation mechanism of its deep heat source is still unclear. In this paper, based on 16 broadband magnetotelluric sounding points, the two-dimensional electrical structure of the crust and mantle in the Huailai area was obtained. Combined with deep seismic reflection and P-wave seismic tomography, the geophysical characteristics of deep heat sources and reservoirs in the Huailai area are described. The Huailai area is characterized by low resistivity and layered reflection above 2 km in depth, which shows the distribution of the Cenozoic sedimentary cover layer. The upper crust is characterized by high resistivity without an obvious reflector, corresponding to the crystalline basement of the basin, whose main lithology is Archean gneiss. There is a highly conductive and bright-spot-reflective structure under the basement, which extends to 100 km, indicating the upwelling of mantle-derived material. Combined with the results of helium isotope tracing, a magma-type geothermal model in the Huailai area is proposed. The upwelling mantle-derived magma material is enriched under the basement to form a heat source. The heat is transferred to the upper crust through heat conduction along the crystalline basement. Then, groundwater circulation brings deep heat to the surface, forming hydrothermal resources. [ABSTRACT FROM AUTHOR]

Timely access of care has been widely recognized as an important dimension of health care quality. Waiting times can affect patient satisfaction and quality of care in the emergency department (ED). This study analyzes a general patient waiting policy such that ED patients who wait beyond a threshold have their wait shortened. Assuming that the policy is implemented to accelerate the long-waiting cases within a short time interval, we transform the original waiting distribution to a piecewise distribution. The objective of this paper is to examine the reliability of the induced waiting system by minimizing the coeffcient of variation (CV) of waiting time. We convert the CV minimization problem to an approximation counterpart using the sampling technique. With patient waiting time data from an emergency department in Singapore, we derive the optimal values of parameters, such as the threshold and the length of the underlying time interval, needed in the policy. Numerical results show that CV and variance of new waiting time will be reduced remarkably by 38% and 58% respectively, in comparison with the original ones. [ABSTRACT FROM AUTHOR]

The admission of emergency patients in a hospital is unscheduled, urgent, and takes priority over elective patients, who are usually scheduled several days in advance. Hospital beds are a critical resource, and the management of elective admissions by enforcing quotas could reduce incidents of shortfall. We propose a distributionally robust optimization approach for managing elective admissions to determine these quotas. Based on an ambiguous set of probability distributions, we propose an optimized budget of variation approach that maximizes the level of uncertainty the admission system can withstand without violating the expected bed shortfall constraint. We solve the robust optimization model by deriving a second order conic problem (SOCP) equivalent of the model. The proposed model is tested in simulations based on real hospital admission data, and we report favorable results for adopting the robust optimization models. [ABSTRACT FROM AUTHOR]

In this paper, we consider the Lagrangian-dual problem of a class of convex optimization problems. We first discuss the semismoothness of the Lagrangian-dual function φ. This property is then used to investigate the second-order properties of the Moreau--Yosida regularization ? of the function φ, e.g., the semismoothness of the gradient g of the regularized function ?. We show that φ and g are piecewise C² and semismooth, respectively, for certain instances of the optimization problem. We establish a relationship between the original problem and the Fenchel conjugate of the regularization of the corresponding Lagrangian dual problem. We also find some instances of the optimization problem whose Lagrangian-dual function φ is not piecewise smooth. However, its regularized function still possesses nice second-order properties. Finally, we provide an alternative way to study the semismoothness of the gradient under the structure of the epigraph of the dual function. [ABSTRACT FROM AUTHOR]

In this paper we discuss the sample average approximation (SAA) method for a class of stochastic programs with nonsmooth equality constraints. We derive a uniform Strong Law of Large Numbers for random compact set-valued mappings and use it to investigate the convergence of Karush-Kuhn-Tucker points of SAA programs as the sample size increases. We also study the exponential convergence of global minimizers of the SAA problems to their counterparts of the true problem. The convergence analysis is extended to a smoothed SAA program. Finally, we apply the established results to a class of stochastic mathematical programs with complementarity constraints and report some preliminary numerical test results. [ABSTRACT FROM AUTHOR]

This paper analyses the properties of the projection mapping over a set defined by a constraint function whose image is possibly a nonpolyhedral convex set. Under some nondegeneracy assumptions, we prove the (strong) semismoothness of the projection mapping. In particular, we derive the strong semismoothness of the projection mapping when the nonpolyhedral convex set under consideration is taken to be the second-order cone or the semidefinite cone. We also derive the semismoothness of the solution to the Moreau–Yosida regularization of the maximum eigenvalue function. [ABSTRACT FROM AUTHOR]