Search

Your search keyword '"Fanny Gallix"' showing total 2 results
Start Over Author "Fanny Gallix" Language english
2 results on '"Fanny Gallix"'

1. An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers

Author

Loraine Jarrosson, Clélia Costechareyre, Fanny Gallix, Séverine Ciré, Fabien Gay, Olivier Imbaud, Romain Teinturier, Elisabetta Marangoni, Karine Aguéra, Céline Delloye-Bourgeois, and Valérie Castellani

Subjects
Biological sciences research methodologies, Cancer, Model organism, Science
Abstract

Summary: Lack of preclinical patient-derived xenograft cancer models in which to conduct large-scale molecular studies seriously impairs the development of effective personalized therapies. We report here an in vivo concept consisting of implanting human tumor cells in targeted tissues of an avian embryo, delivering therapeutics, evaluating their efficacy by measuring tumors using light sheet confocal microscopy, and conducting large-scale RNA-seq analysis to characterize therapeutic-induced changes in gene expression. The model was established to recapitulate triple-negative breast cancer (TNBC) and validated using TNBC standards of care and an investigational therapeutic agent.

Published
2021
Full Text
View/download PDF

2. Modeling breast cancer by grafting patient tumor samples in the avian embryo: an in vivo platform for therapy evaluation coupled to large scale molecular analyses

Author

Loraine Jarrosson, Clélia Costechareyre, Fanny Gallix, Séverine Ciré, Fabien Gay, Olivier Imbaud, Elisabetta Marangoni, Karine Aguéra, Céline Delloye-Bourgeois, Valérie Castellani, Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
0303 health sciences, Therapy Evaluation, business.industry, [SDV]Life Sciences [q-bio], Cancer, Avian embryo, medicine.disease, 3. Good health, law.invention, Human tumor, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Confocal microscopy, law, In vivo, 030220 oncology & carcinogenesis, Cancer research, medicine, business, Triple-negative breast cancer, 030304 developmental biology
Abstract

Lack of preclinical patient-derived xenograft (PDX) cancer models in which to conduct large scale molecular studies seriously impairs the development of effective personalized therapies. We report here on an in vivo concept consisting of implanting human tumor cells in targeted tissues of an avian embryo, delivering therapeutics, evaluating their efficacy by measuring tumors using light sheet confocal microscopy, and conducting large scale RNAseq analysis to characterize therapeutic-induced changes in gene expression. The model was established to recapitulate triple negative breast cancer (TNBC) and validated using TNBC standards of care (SOCs) and an investigational therapeutic agent.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results