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The incidence of peroneal tendon disorders in the population is unknown and they are usually overlooked. We report two cases of peroneus brevis injuries and a comprehensive literature review was performed. The first case was a 53-year-old man presented with persistent pain on the lateral aspect on the left ankle during the last four years and difficulty to bear weight during the last year. MRI showed longitudinal tear of peroneus brevis tendon and the patient underwent surgical treatment. The second case was a 46-year-old woman with persistent pain on the lateral aspect of the ankle with a history of a road traffic accident two years ago. Although MRI showed a peroneus brevis tendon tear, this was a false positive finding. Surgical treatment revealed no tear and symphysiolysis managed to relieve patient's symptoms. Even though MRI is the most effective diagnostic tool in depicting peroneal tendon injuries, there are false positive findings. In cases when symptoms persist, surgical exploration is indicated.

Scanning oncological patients with 18F-fluorodeoxyglucose (18F-FDG) for their disease staging, evaluation of treatment response, and monitoring/management has become a standard of care. The use of the radioactive fluorine in the FDG molecule helps establish cell/tissue lines high on glucose consumption and hence metabolically active. Abnormalities are detected on the scan as areas of increased uptake. However, these areas of increased (hot) uptakes do not necessarily translate into a pathological finding. A comprehensive knowledge of the uptakes of the tracer and the potential “pitfalls” that may be associated with them should be known and kept in mind during scan reading. One such pitfall is the “hot clot” or “pulmonary emboli,” and we report two such cases encountered at our setup and discuss their causes and how they should be identified and avoided.

This paper is a response to the study of Meyer-Rochow et al. (2020), who found a statistically significant increase of suicides during full moon among women in the region of Oulu, Finland. We argue that this may be a false-positive finding because of subgroups not specified a-priori and the many negative previous findings. Furthermore, we could not replicate the findings in a larger Austrian sample.

Background The F-18 fluorodeoxyglucose positron emission/computed tomography (FDG PET/CT) has become an established diagnostic imaging for malignancy. However, there are other diseases that can also be identified with FDG, some of them are infections such as tuberculosis. Case presentation In this case report, two patients showed multiple hypermetabolic tuberculosis lesions on FDG PET/CT, with one of the patients having history of malignancy. The objective of the present case report is to emphasize the need to use other differential diagnosis techniques for tuberculosis especially in tuberculosis-endemic countries when interpreting FDG PET/CT. Conclusion By analyzing diagnostic imaging alone, there is a high chance of misinterpreting asymptomatic tuberculosis patient as having malignancy. Therefore, there is need for correlation with clinical data as well as other imaging modalities and PET/CT with more specific tracer in order to differentiate malignancy from benign disease such as tuberculosis.

Primary Epstein–Barr virus (EBV) infection is common in childhood, and dual positivity of serum EBV IgM and cytomegalovirus (CMV) IgM antibodies occur in some cases. This study aimed to evaluate the cause of EBV and CMV IgM dual positivity to determine whether it represents a false-positive finding or a true coinfection. A total of 494 children diagnosed with primary EBV infection, manifesting as infectious mononucleosis, were recruited. The diagnosis was based on positive EBV viral capsid antigen (VCA) IgM antibodies, and serum CMV IgM antibodies and liver enzymes were also evaluated in 149 subjects. Of 149 children with primary EBV infection, 40 (26.8%) had serum EBV VCA IgM and CMV IgM dual positivity. However, true CMV infection was confirmed only in 1 child of 40 (2.5%) who was positive for both serum CMV Ag and urine CMV polymerase chain reaction (PCR) and negative for serum CMV IgG antibody. Among the children with primary EBV infection, the rate of dual positivity was higher in infants and lower in adolescents (P = .013). Liver enzymes were more significantly elevated in children with dual positivity than in those with negative results for CMV IgM antibodies (P = .026), which correlated with the serum EBV and CMV IgM titers. Serum EBV and CMV IgM dual positivity are more prevalent in children with primary EBV infection than what was previously reported. Our results indicate that serum EBV and CMV IgM dual positivity represents a false-positive finding, as opposed to an actual CMV coinfection, possibly due to antigenic cross-reactivity.

Avid functional (18)F-FDG uptake of skeletal muscle is a known false positive finding of PET-CT study especially after involuntary muscle exercise just prior to the study. We describe the case of a 50-year-old man in whom the finding of avid (18)F-FDG uptake of pectoralis major muscle was encountered during investigation of metastatic melanoma.

Methods 24 primary and pre-treated patients diagnosed with multiple myeloma according to the International Myeloma Working Group criteria were examined by F-FDG PET/CT and whole-body MRI including DWI (b= 0, and b= 800 s/mm). F-FDG PET/MRI was used to achieve correct matching of findings in the corresponding PET/ CT study. Suspicious lesions were defined by the imaging gold-standard of nonenhanced T1-w/T2-wMRI and low-dose CT.