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1. First-line therapy with palbociclib in patients with advanced HR+/HER2− breast cancer: The real-life study PALBOSPAIN

Author: Martínez-Jañez, N., Ezquerra, M. Bellet, Manso Sanchez, L. M., Carrasco, F. Henao, Torres, A. Anton, Morales, S., Ortega, P. Tolosa, Gil, V. L. Obadia, Sampedro, T., Conejero, R. Andrés, Calvo-Martinez, L., Galve-Calvo, E., López, R., de la Pena, F. Ayala, Lopez-Tarruella, S., de Araguiz, B. A. Hernando Fernandez, Ruiz, L. Boronat, Cardenas, T. Martos, Chacon, J. I., and Antón, F. Moreno
Published: 2024
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2. Coaching the coaches: exploring the effectiveness of the ‘Move Well Be strong’ youth injury prevention programme for grassroot coaches and PE teachers

Author: J. D. Hughes, F. Ayala, W. M. Roberts, K. Wing, and M. B. A. De Ste Croix
Subjects: Youth, injury prevention, coach education, RE-AIM framework, Medicine
Abstract: Introduction Coaches play a major role in developing movement in their performers, especially at grassroots levels. However, there are significant knowledge gaps amongst grassroots coaches and physical education (PE) teachers regarding movement competency and injury prevention programs. This study aimed to explore the effectiveness of knowledge gain, adoption and implementation following a youth injury prevention workshop for grassroots coaches and PE teachers.Methods 56 grassroots coaches and PE teachers completed a validated questionnaire exploring use, knowledge, attitude towards and confidence to deliver youth movement competency training before and after an online workshop. Bayesian Wilcoxon signed-rank tests were used to assess the knowledge, attitude, and confidence to deliver an injury prevention programme following the workshop. For all the Bayesian inference tests run, the Bayesian factor (BF10) was interpreted using the evidence categories ranging from extreme evidence (BF10 > 100) to anecdotical evidence (BF10 < 1).Results Post-workshop there was a 34% increase in respondents indicating that they had greater knowledge of injury prevention issues (55% pre-workshop vs 89% post-workshop) with statistically positive and moderate effects (BF10 > 100 [extreme evidence]). There was also a 25% increase in respondents indicating that they had a more sympathetic attitude towards injury prevention (67% sympathetic pre-workshop vs 93% sympathetic post-workshop) with statistically moderate effects (BF10 = 87.4 [very strong evidence]). A 19% increase in attendees’ confidence to deliver an injury prevention programme was observed (69% high pre-workshop vs. 89% high post-workshop) with statistically moderate effects (BF10 = 85.9 [very strong evidence]). 100% of participants indicated an intent to adopt the injury prevention programme.Conclusions An online workshop increased knowledge and confidence in grassroots coaches and PE teachers to deliver a youth injury prevention programme. Knowledge gained from training and upskilling created a positive attitude and confidence to deliver movement competency into coaching. Appropriate resources need to be developed and delivered in an accessible way to grassroots coaches and PE teachers via workshops and should be included in governing body coaching awards or as continuing professional development for youth coaches and PE teachers.
Published: 2024
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3. Comparison between Wright and Shukla formulas: which is better for the placement of umbilical catheters in newborns ≤ 1500 g?

Author: Diana A. Castañeda-Pérez, Carolina Villegas-Álvarez, Adolfo San Román-Flores, Mauricio Pierdant-Pérez, Daniel Herbert-Anaya, Jorge G. Reyes-Vaca, Jorge F. Ayala-González, and Francisco J. Escalante-Padrón
Subjects: Umbilical veins. Umbilical arteries. Peripheral catheterization. Umbilicus. Infant. Very low birth weight., Pediatrics, RJ1-570, Public aspects of medicine, RA1-1270
Abstract: Background: Intravascular venous (VUC) or arterial (AUC) umbilical catheter placement is the most frequent invasive procedure in the neonatal intensive care unit (NICU). Either Wright’s or Shukla’s formula is used to introduce the catheters. However, Shukla’s formula is associated with incorrect insertion, especially for newborns < 1500 g. This study aimed to determine by chest X-ray if Wright’s formula is better than Shukla’s formula for the correct placement of umbilical catheters in newborns ≤ 1500 g. Methods: We included patients admitted to the NICU of a secondary-level hospital between 2021- 2022 who received VUC or AUC through the Wright or Shukla formulas. Results: A total of 129 newborns were included: 78 with VUC and 51 with AUC. In VUC, 50% with Wright and 36.8% with Shukla formulas had the correct location, (p = 0.24). In AUC, 56.6 % with Wright and 52.4% with Shukla formulas were placed correctly placed, (p = 0.76). VUC with weight < 1000 g were correctly placed in 36.4% with Wright and 33.3% with Shukla formulas (p = 0.58). VUC in newborns > 1000 g were correctly placed in 66.6% with Wright and 38.4% with Shukla formulas (p = 0.065). AUC in newborns < 1000 g were correctly placed in 45% using Wright and 42.9% Shukla formulas (p = 0.63). AUC in newborns > 1000 g were correctly placed in 80% using Wright and 57.1% Shukla formulas (p = 0.23). Conclusions: We found 13% more correctly placed VUC using Wright’s formula. Moreover, Wright’s formula was 29% above Shukla’s VUC placement in neonates > 1000 g, although there was no significant difference due to the sample size.
Published: 2023
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4. Adopting service suppliers for servitisation: which type of supplier involvement is more effective?

Author: F. Ayala, Néstor, Gaiardelli, Paolo, Pezzotta, Giuditta, Le Dain, Marie Anne, and Frank, Alejandro G.
Published: 2021
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5. Antioxidants in Oak (Quercus sp.): Potential Application to Reduce Oxidative Rancidity in Foods

Author: Elsa Daniela Othón-Díaz, Jorge O. Fimbres-García, Marcela Flores-Sauceda, Brenda A. Silva-Espinoza, Leticia X. López-Martínez, Ariadna T. Bernal-Mercado, and Jesus F. Ayala-Zavala
Subjects: Quercus, antioxidants, phenolic compounds, food rancidity, lipid oxidation, Therapeutics. Pharmacology, RM1-950
Abstract: This review explores the antioxidant properties of oak (Quercus sp.) extracts and their potential application in preventing oxidative rancidity in food products. Oxidative rancidity negatively impacts food quality, causing changes in color, odor, and flavor and reducing the shelf life of products. The use of natural antioxidants from plant sources, such as oak extracts, has gained increasing interest due to potential health concerns associated with synthetic antioxidants. Oak extracts contain various antioxidant compounds, including phenolic acids, flavonoids, and tannins, which contribute to their antioxidative capacity. This review discusses the chemical composition of oak extracts, their antioxidative activity in different food systems, and the safety and potential challenges related to their application in food preservation. The potential benefits and limitations of using oak extracts as an alternative to synthetic antioxidants are highlighted, and future research directions to optimize their application and determine their safety for human consumption are suggested.
Published: 2023
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6. First-line therapy with palbociclib in patients with advanced HR+/HER2− breast cancer: The real-life study PALBOSPAIN.

Author: Martínez-Jañez, N., Ezquerra, M. Bellet, Manso Sanchez, L. M., Carrasco, F. Henao, Torres, A. Anton, Morales, S., Ortega, P. Tolosa, Gil, V. L. Obadia, Sampedro, T., Conejero, R. Andrés, Calvo-Martinez, L., Galve-Calvo, E., López, R., de la Pena, F. Ayala, Lopez-Tarruella, S., de Araguiz, B. A. Hernando Fernandez, Ruiz, L. Boronat, Cardenas, T. Martos, Chacon, J. I., and Antón, F. Moreno
Abstract: Purpose: To evaluate the efficacy and safety of first-line therapy with palbociclib in a Spanish cohort treated after palbociclib approval. Methods: PALBOSPAIN is an observational, retrospective, multicenter study evaluating real-world patterns and outcomes with 1 L palbociclib in men and women (any menopausal status) with advanced HR+/HER2– BC diagnosed between November 2017 and November 2019. The primary endpoint was real-world progression-free survival (rw-PFS). Secondary endpoints included overall survival (OS), the real-world response rate (rw-RR), the clinical benefit rate, palbociclib dose reduction, and safety. Results: A total of 762 patients were included. The median rw-PFS and OS were 24 months (95% CI 21–27) and 42 months (40-not estimable [NE]) in the whole population, respectively. By cohort, the median rw-PFS and OS were as follows: 28 (95% CI 23–39) and 44 (95% CI 38-NE) months in patients with de novo metastatic disease, 13 (95% CI 11–17) and 36 months (95% CI 31–41) in patients who experienced relapse < 12 months after the end of ET, and 31 months (95% CI 26–37) and not reached (NR) in patients who experienced relapse > 12 months after the end of ET. rw-PFS and OS were longer in patients with oligometastasis and only one metastatic site and those with non-visceral disease. The most frequent hematologic toxicity was neutropenia (72%; grade ≥ 3: 52.5%), and the most common non-hematologic adverse event was asthenia (38%). Conclusion: These findings, consistent with those from clinical trials, support use of palbociclib plus ET as 1 L for advanced BC in the real-world setting, including pre-menopausal women and men. Trial registration number: NCT04874025 (PALBOSPAIN). Date of registration: 04/30/2021 retrospectively registered. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. ADDRESSING THE INFILTRATIVE PATTERN: COMPLEX DIAGNOSIS

Author: A.L. Ordóñez-Vázquez, J. Prieto-Nava, F. Ayala-Ochoa, A. Heredia-Jara, L. Montiel-Velázquez, and I. López-Méndez
Subjects: Specialties of internal medicine, RC581-951
Abstract: Introduction and objective: Alterations in liver function tests are frequent, so the approach based on the predominant alteration and the patient's medical history is relevant. Carrying out a liver biopsy in cases of diagnostic doubt is imperative. The objective of this work is to describe a clinical case of an infiltrative pattern approach that culminated in the diagnosis of Hepatosplenic T-cell Lymphoma (HSCTL). Patients and Methods: Clinical case report. Presentation. Woman, 72 years old. History of a sister with cirrhosis. Consumption of alcohol and herbalists; arterial hypertension and Sjögren. He was admitted for persistent fatigue and jaundice. Laboratories with anemia, thrombocytopenia and kidney injury; Hepatic biochemistry with a predominantly cholestatic pattern at the expense of alkaline phosphatase and direct hyperbilirubinemia. Without acute liver failure. By imaging the liver, vessels and normal bile duct; splenomegaly; Negative hepatitis viral panel, positive ANAs and Anti-actin, negative antimitochondrials, normal immunoglobulins. HAI vs. DILI / HILI is suspected. Liver biopsy reports HSTCL-type lymphoproliferative process (Figure 1). It was supplemented with bone marrow aspirate and PET-CT. He started prednisone and cyclophosphamide. Discussion: The systematic approach to altered liver biochemistry requires integrating personal and family risk factors for liver disease. The infiltrative pattern that resembles the cholestatic one represents a diagnostic challenge as it is little recognized. In this case, we report a rare neoplasm corresponding to 5% of peripheral T lymphomas; they usually develop in young adults and in the absence of lymphadenopathy. It also has an adverse prognosis due to refractoriness to chemotherapy. Conclusion: The HSTCL presented in this clinical case represents a complex and infrequent diagnosis. The symptoms and age group were atypical and the identification was possible through a systematic evaluation of the infiltrative pattern and differential diagnoses.The authors declare that there is no conflict of interest.
Published: 2022
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8. Facing Resistant Bacteria with Plant Essential Oils: Reviewing the Oregano Case

Author: Jorge O. Fimbres-García, Marcela Flores-Sauceda, Elsa Daniela Othon-Díaz, Alfonso García-Galaz, Melvin R. Tapia-Rodríguez, Brenda A. Silva-Espinoza, and Jesus F. Ayala-Zavala
Subjects: Lippia graveolens, carvacrol, antibacterial resistance, ESKAPE group, co-cultures, synergism, Therapeutics. Pharmacology, RM1-950
Abstract: Antibiotic resistance is a serious global threat, and the misuse of antibiotics is considered its main cause. It is characterized by the expression of bacterial defense mechanisms, e.g., β-lactamases, expulsion pumps, and biofilm development. Acinetobacter baumannii and Pseudomonas aeruginosa are antibiotic-resistant species that cause high morbidity and mortality. Several alternatives are proposed to defeat antibiotic resistance, including antimicrobial peptides, bacteriophages, and plant compounds. Terpenes from different plant essential oils have proven antimicrobial action against pathogenic bacteria, and evidence is being generated about their effect against antibiotic-resistant species. That is the case for oregano essential oil (Lippia graveolens), whose antibacterial effect is widely attributed to carvacrol, its main component; however, minor constituents could have an important contribution. The analyzed evidence reveals that most antibacterial evaluations have been performed on single species; however, it is necessary to analyze their activity against multispecies systems. Hence, another alternative is using plant compounds to inactivate hydrolytic enzymes and biofilms to potentiate antibiotics’ effects. Despite the promising results of plant terpenes, more extensive and deep mechanistic studies are needed involving antibiotic-resistant multispecies to understand their full potential against this problem.
Published: 2022
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9. Antibiofilm Action of Plant Terpenes in Salmonella Strains: Potential Inhibitors of the Synthesis of Extracellular Polymeric Substances

Author: Julian J. Palomares-Navarro, Ariadna T. Bernal-Mercado, Gustavo A. González-Aguilar, Luis A. Ortega-Ramirez, Miguel A. Martínez-Téllez, and Jesús F. Ayala-Zavala
Subjects: biofilm formation, exopolymeric substances, control biofilm, virulence, terpenoids compounds, foodborne pathogen, Medicine
Abstract: Salmonella can form biofilms that contribute to its resistance in food processing environments. Biofilms are a dense population of cells that adhere to the surface, creating a matrix composed of extracellular polymeric substances (EPS) consisting mainly of polysaccharides, proteins, and eDNA. Remarkably, the secreted substances, including cellulose, curli, and colanic acid, act as protective barriers for Salmonella and contribute to its resistance and persistence when exposed to disinfectants. Conventional treatments are mostly ineffective in controlling this problem; therefore, exploring anti-biofilm molecules that minimize and eradicate Salmonella biofilms is required. The evidence indicated that terpenes effectively reduce biofilms and affect their three-dimensional structure due to the decrease in the content of EPS. Specifically, in the case of Salmonella, cellulose is an essential component in their biofilms, and its control could be through the inhibition of glycosyltransferase, the enzyme that synthesizes this polymer. The inhibition of polymeric substances secreted by Salmonella during biofilm development could be considered a target to reduce its resistance to disinfectants, and terpenes can be regarded as inhibitors of this process. However, more studies are needed to evaluate the effectiveness of these compounds against Salmonella enzymes that produce extracellular polymeric substances.
Published: 2022
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10. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author: Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. 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Robiro Robiro, M. Roca, C. Roca Saumell, C. Rodrigo, E. Rodriguez, M. Rodriguez Garcia, S. Saez Jimenez, P. Sanchez Calderon, L. Sanchez Mendez, S. Sanchez Parra, C. Santolaya, M.R. Senan Sanz, A. Seoane Blanco, E. Serralvo, N. Sierra, C. Simon Valero, J. Sorribes Lopez, M. Teixido Fontanillas, M. Terns Riera, G. Tobajas, C. Torres, J. Torres Marques, M. Ubeda Pastor, M. Rosenqvist, A. Wirdby, J. Linden, K. Henriksson, M. Elmersson, A. Egilsson, U. Börjesson, G. Svärd, B. Liu, A. Lindh, L.-B. Olsson, M. Gustavsson, Lars Andersson, Lisbeth Andersson, L. Benson, C. Bothin, A. Hajimirsadeghi, K. Kadir, M. Ericsson, A. Ohlsson, H. Lindvall, P. Svensson, K. Thorne, H. Handel, P. Platonov, B. Eriksson, I. Timberg, K. Romberg, M. Crisby, J.-E. Karlsson, S.A. Jensen, A. Andersson, L. Malmqvist, B. Martinsson, F. Bernsten, J. Engdahl, J. Thulin, A. Hot-Bjelac, P. Stalby, H. Aaröe, E. Ahbeck, H. Ahlmark, F. Al-Khalili, G. Bonkowski, S. Dzeletovic, A.-B. Ekstrand, G.-B. Eriksson, K. Floren, C. Grässjö, S. Hahn, P. Jaensson, B. Jansson, J.-H. Jansson, R.-M. Kangert, A. Koch, D. Kusiak, A. Lettenström, A. Lindberg, C.-J. Lindholm, A. Mannermyr, K. Mansson, M. Millborg, C. Nilsson, A.-M. Ohlin, A. Olofsson, A. Osberg, A. Pedersen, K. Risbecker, K. Rosenberg, J. Samuelsson, M. Shayesteh, K. Skoglund, M. Stjernberg, C. Thorsen, J. Steffel, J.H. Beer, J. Debrunner, D. Amstutz, J. Bruegger, G. Elise, A. Grau, A. Guinand, I. Henriette, E. Saga, S. Winnik, A. Parkhomenko, I. Rudyk, V. Tseluyko, O. Karpenko, S. Zhurba, I. Kraiz, I. Kupnovytska, N. Serediuk, Y. Mostovoy, O. Ushakov, O. Koval, I. Kovalskyi, Y. Svyshchenko, O. Sychov, M. Stanislavchuk, O. Kraydashenko, A. Yagensky, S. Tykhonova, I. Fushtey, R. Belegai, G. Berko, L. Burdeuna, O. Chabanna, I. Daniuk, A. Ivanov, E. Kamenska, P. Kaplan, O. Khyzhnyak, S. Kizim, O. Matova, O. Medentseva, V. Mochonyi, M. Mospan, V. Nemtsova, T. Ovdiienko, O. Palamarchuk, M. Pavelko, R. Petrovskyy, D. Plevak, O. Proshak, S. Pyvovar, L. Rasputina, O. Romanenko, O. Romanova, A. Sapatyi, O. Shumakov, R. Stets, L. Todoriuk, V. Varenov, D. Fitzmaurice, N. Chauhan, D. Goodwin, P. Saunders, R. Evans, J. Leese, P.S. Jhittay, A. Ross, M.S. Kainth, G. Pickavance, J. McDonnell, A. Williams, T. Gooding, H. Wagner, S. Suryani, A. Singal, S. Sircar, R. Bilas, P. Hutchinson, A. Wakeman, M. Stokes, N. Paul, M. Aziz, C. Ramesh, P. Wilson, S. Franklin, S. Fairhead, J. Thompson, V. St Joseph, G. Taylor, D. Tragen, D. Seamark, C. Paul, M. Richardson, A. Jefferies, H. Sharp, H. Jones, C. Giles, M. Page, O. Oginni, J. Aldegather, S. Wetherwell, W. Lumb, P. Evans, F. Scouller, N. Macey, Y. Stipp, R. West, S. Thurston, P. Wadeson, J. Matthews, P. Pandya, A. Gallagher, T. Railton, B. Sinha, D. Russell, J.A. Davies, P. Ainsworth, C.P. Jones, P. Weeks, J. Eden, D. Kernick, W. Murdoch, L. Lumley, R.P. Patel, S.W. Wong, M. Saigol, K. Ladha, K. Douglas, D.F. Cumberlidge, C. Bradshaw, G. Van Zon, K.P. Jones, M.J. Thomas, E. Watson, B. Sarai, N. Ahmad, W. Willcock, J. Cairns, S. Sathananthan, N. de Kare-Silver, A. Gilliland, E. Strieder, A. Howitt, B. Vishwanathan, N. Bird, D. Gray, M. Clark, J. Bisatt, J. Litchfield, E. Fisher, T. Fooks, A.R. Kelsall, E. Alborough, J. Wakeling, M. Parfitt, K. Milne, S. Rogers, R. Priyadharshan, J.L. Oliver, E. Davies, S. Abushal, M. Jacobs, C. Hutton, N.I. Walls, R. Thompson, C. Chigbo, S.M.A. Zaidi, M. Howard, K.C. Butter, S. Barrow, H. Little, I.U. Haq, L. Gibbons, S. Glencross, A.J. McLeod, K. Poland, C. Mulholland, A. Warke, P. Conn, G. Burns, R.N. Smith, S. Lowe, R. Kamath, H.S. Dau, J. Webster, I. Hodgins, S. Vercoe, P.C. Roome, H. Pinnock, J.R.A. Patel, A. Ali, N. Hart, R. Davies, E. Stuart, C.A. Neden, M. Danielsen, R. Heath, P. Sharma, S. Galloway, C. Hawkins, R. Oliver, M. Aylward, S. Mannion, M. Braddick, D. Edwards, A.C. Rothwell, A. Sabir, F. Choudhary, S. Khalaque, A. Wilson, S. Peters, W. Coulson, N. Roberts, A. Heer, S. Coates, B. Ward, D. Jackson, S. Walton, D. Shepherd, M. Sterry, T. Wong, M. Boon, R. Bunney, R. Haria-Shah, R.T. Baron, S. Davies, T. Schatzberger, N. Hargreaves, T. Stephenson, H. Choi, R. Batson, L. Lucraft, T. Myhill, S. Estifano, D. Geatch, J. Wilkinson, R. Veale, K. Forshaw, T. Davies, K. Zaman, P. Vinson, C. Liley, M. Bandrapalli, P. McGinty, R. Wastling, P. McEleny, A. Beattie, P. Cooke, M. Wong, J. Gunasegaram, M. Pugsley, S. Ahmad, C. A'Court, J. Ayers, J. Bennett, S. Cartwright, S. Dobson, C. Dooldeniya, A. Flynn, R. Fox, J. Goram, A. Halpin, A. Hay, P. Jacobs, L. Jeffers, L. Lomax, I. Munro, R. Muvva, M. Nadaph, K. Powell, S. Randfield, D. Redpath, R. Reed, M. Rickenbach, G. Rogers, P.B. Saunders, C. Seamark, J. Shewring, P. Simmons, H. Simper, H. Stoddart, A. Sword, N. Thomas, A. Thomson, H. Gibbs, A. Blenkhorn, B. Singh, W. Van Gaal, W. Abhayaratna, R. Lehman, P. Roberts-Thomson, J. Kilian, D. Coulshed, A. Catanchin, D. Colquhoun, H. Kiat, D. Eccleston, J. French, L. Zimmett, B. Ayres, T. Phan, P. Blombery, D. Crimmins, D. O'Donnell, A. Choi, P. Astridge, M. Arstall, N. Jepson, M. Binnekamp, A. Lee, J. Rogers, G. Starmer, P. Carroll, J. Faunt, A. Aggarwala, L. Barry, C. Batta, R. Beveridge, A. Black, M. Bonner, J. Boys, E. Buckley, M. Campo, L. Carlton, A. Connelly, B. Conway, D. Cresp, H. Dimitri, S. Dixon, M. Dolman, M. Duroux, M. Eskandari, R. Eslick, A. Ferreira-Jardim, T. Fetahovic, D. Fitzpatrick, R. Geraghty, J. Gibbs, T. Grabek, M.H. Modi, K. Hayes, M.P. Hegde, L. Hesketh, B. Hoffmann, B. Jacobson, K. Johnson, C. Juergens, I. Kassam, V. Lawlor, M. Lehman, S. Lehman, D. Leung, S. Mackay, M. MacKenzie, C. McCarthy, C. McIntosh, L. McKeon, H. Morrison, C. Mussap, J.-D. Myers, V. Nagalingam, G. Oldfield, V. O'May, J. Palmer, L. Parsons, K. Patching, T. Patching, V. Paul, M. Plotz, S. Preston, H. Rashad, M. Ratcliffe, S. Raynes, J. Rose, L. Sanders, M. Seremetkoska, H. Setio, S. Shone, P. Shrestha, C. Singh, C. Singleton, N. Stoyanov, S. Sutcliffe, K. Swaraj, J. Tarrant, S. Thompson, I.M. Tsay, M. Vorster, A. Waldman, L. Wallis, E. Wilford, K. Wong, S.J. Connolly, A. Spyropoulos, J. Eikelboom, R. Luton, M. Gupta, A.S. Pandey, S. Cheung, R. Leader, P. Beaudry, F. Ayala-Paredes, J. Berlingieri, J. Heath, G. Poirier, M. Du Preez, R. Nadeau, G. Dresser, R. Dhillon, T. Hruczkowski, B. Schweitzer, B. Coutu, P. Angaran, P. MacDonald, S. Vizel, S. Fikry, R. Parkash, A. Lavoie, J. Cha, B. Ramjattan, J. Bonet, K. Ahmad, L. Aro, T. Aves, K. Beaudry, C. Bergeron, J. Bigcanoe, N. Bignell, L. Breakwell, E. Burke, L. Carroll, B. Clarke, T. Cleveland, S. Daheb, P. Dehghani, I. Denis, Z. Djaidani, P. Dorian, S. Douglass, J. Dunnigan, A. Ewert, D. Farquhar, A. Fearon, L. Ferleyko, D. Fournier, B. Fox, M.-C. Grenier, W. Gulliver, K. Haveman, C. Hines, K. Hines, A.M. Jackson, C. Jean, G. Jethoo, R. Kahlon, S. Kelly, R. Kim, V. Korley, J. Kornder, L. Kwan, J. Largy, C. Lewis, S. Lewis, I. Mangat, R. Moor, J. Navratil, I. Neas, J. Otis, R. Otis, M. Pandey, F. Petrie, A. Pinter, M. Raines, P. Roberts, M. Robinson, G. Sas, S. Schulman, L. Snell, S. Spearson, J. Stevenson, T. Trahey, S. Wong, D. Wright, H. Ragy, A. Abd El-Aziz, S.K. Abou Seif, M.G. El Din, S. El Etriby, A. Elbahry, A. El-Etreby, M. Elkhadem, A. Katta, T. Khairy, A. Mowafy, M. Nawar, A. Ohanissian, A. Reda, M. Reda, H. Salem, N. Sami, S. Samir, M. Setiha, M. Sobhy, A. Soliman, N. Taha, M. Tawfik, E. Zaatout, D. Kettles, J. Bayat, H. Siebert, A. Horak, Y. Kelfkens, R. Garda, T. Pillay, M. Guerra, L. van Zyl, H. Theron, A. Murray, R. Louw, D. Greyling, P. Mntla, V. Ueckermann, R. Loghdey, S. Ismail, F. Ahmed, J. Engelbrecht, A. Ramdass, S. Maharajh, W. Oosthuysen, G. Angel, C. Bester, M. Booysen, C. Boshoff, C. Cannon, S. Cassimjee, C. Chami, G. Conway, A. Davids, L. de Meyer, G. Du Plessis, T. Ellis, L. Henley, M. Karsten, E. Loyd, J. Marks, L. Mavhusa, M. Mostert, A. Page, L. Rikhotso, M. Salie, J. Sasto, F. Shaik, A. Skein, L. Smith, G. Tarr, T. Tau, F. van Zyl, W. Al Mahmeed, G. Yousef, A. Agrawal, M. Nathani, M. Ibrahim, E.M. Esheiba, R. Singh, A. Naguib, M. Abu-Mahfouz, M. Al Omairi, A. Al Naeemi, R. Maruthanayagam, N. Bazargani, A. Wassef, R. Gupta, M. Khan, B. Subbaraman, A. Abdul, A. Al Mulla, S. El Bardisy, P. Haridas, S. Jadhav, K. Magdaluyo, M. Makdad, I. Maqsood, R. Mohamed, N. Sharma, R. Sharma, M. Thanzeel, S.Z. Goldhaber, R. Canosa, P. Rama, E. Blumberg, J. Garcia, P. Mullen, V. Wilson, A. Quick, K. Ferrick, W.M. Kutayli, M. Cox, M. Franco, S. Falkowski, R. Mendelson, M. Williams, S. Miller, S. Beach, A. Alfieri, T. Gutowski, I. Haque, R. Reddy, W. Ahmed, P. Delafontaine, D. Diercks, D. Theodoro, K. Remmel, M. Alberts, R. Ison, H. Noveck, P. Duffy, S. Pitta, D. Nishijima, C. Treasure, N. Asafu-Adjaye, K. Ball, M. Bartlett, M. Bentley, S. Bowers, A. Brown, A. Browne, J. Cameron-Watts, M. Canova, D. Cassidy, K. Cervellione, S. Congal, J. DePauw, A. Dickerson, M. Eley, L. Evans, S. Felpel, K. Ferdinand, D. Fielder, P. Gentry, A. Haideri, F. Hakimi, T. Harbour, E. Hartranft, B. Hawkins, M. Headlee, L. Henson, C. Herrick, T. Hicks, S. Jasinski, A. Jones, L. Jones, P. Jones, S. Karl, M. Keeling, J. Kerr, P. Knowles, J. Langdon, M. Lay, J.A. Lee, T. Lincoln, E. Malone, A. Merliss, D. Merritt, J. Minardo, B. Mooso, C. Orosco, V. Palumbo, M. Parker, T. Parrott, S. Paserchia, G. Pearl, J. Peterson, N. Pickelsimer, T. Purcell, J. Raynor, S. Raziano, C. Richard, T. Richardson, C. Robertson, A. Sage, T. Sanghera, P. Shaw, J. Shoemaker, K. Smith, B. Stephanie, A. Thatcher, H. Theobald, N. Thompson, L. Treasure, T. Tripti, C. Verdi, and V. Worthy
Subjects: Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
Published: 2018
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11. Prevalence of sleep disorders, daytime sleepiness and clinical symptomatology in older adults

Author: M.Á. Mendoza-Meléndez, U. Jimenez-Correa, A. Gallegos-Cari, F. Ayala-Guerrero, and A. Jiménez-Anguiano
Subjects: Elderly, Obstructive sleep apnoea, Epidemiology, Sleep medicine, Polysomnography, REM latency, Medicine (General), R5-920
Abstract: Introduction: With ageing, changes occur that affect the quality and quantity of sleep. These changes could cause sleep disorders in older adults, causing severe consequences for health and quality of life. However, in Mexico there are no studies addressing the prevalence of sleep disorders in older adults. Objective: To determine the prevalence of sleep disorders, daytime sleepiness and clinical symptomatology in older adults seen at the UNAM Sleep Disorder Clinic in the General Hospital of México. Materials and methods: A retrospective analysis of 191 medical records and 148 polysomnographic records from adults over 65 years old who were seen at the UNAM School of Medicine Sleep Disorder Clinic from 2009 to 2013 was performed. Results: 82.2% of patients were diagnosed with Obstructive Sleep Apnoea Syndrome (OSAS). The associated factors found were night-time awakenings (89%), medical comorbidities (84.5%), difficulty waking (70.7%), being overweight or obese (69.1%), among others. Of the total sleep time, they spent 14.2% in N1, 53.8% in N2, 16.1% in N3 and 15.4% in REM. Moreover, a REM sleep latency of 160 min was found. Discussion: Caring for the elderly is a challenge for healthcare systems. The study of sleep disorders is important because of its effects on health and quality of life, so understanding the clinical characteristics of this population will improve the diagnosis, management and referral of these patients.
Published: 2016
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12. Building digital servitization ecosystems: An analysis of inter-firm collaboration types and social exchange mechanisms among actors

Author: Lucas Santos Dalenogare, Marie-Anne Le Dain, Néstor F. Ayala, Giuditta Pezzotta, and Alejandro G. Frank
Subjects: Service partners, Management of Technology and Innovation, Digital servitization, Collaboration, Ecosystems, Smart product-service systems, Settore ING-IND/17 - Impianti Industriali Meccanici, General Engineering
Published: 2023

13. The prognostic impact of additional intrathoracic findings in patients with cancer-related pulmonary embolism

Author: Jiménez-Fonseca, P., Carmona-Bayonas, A., Font, C., Plasencia-Martínez, J., Calvo-Temprano, D., Otero, R., Beato, C., Biosca, M., Sánchez, M., Benegas, M., Varona, D., Faez, L., Antonio, M., de la Haba, I., Madridano, O., Solis, M. P., Ramchandani, A., Castañón, E., Marchena, P. J., Martín, M., de la Peña, F. Ayala, Vicente, V., and On behalf of the EPIPHANY study investigators and the Asociación de Investigación de la Enfermedad Tromboembólica de la Región de Murcia
Published: 2017
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14. A fugacity-based Lattice Boltzmann method for multicomponent multiphase systems

Author: Muzammil Soomro, Luis F. Ayala, Cheng Peng, and Orlando M. Ayala
Subjects: Fluid Dynamics (physics.flu-dyn), FOS: Physical sciences, Physics - Fluid Dynamics
Abstract: The free energy model can extend the Lattice Boltzmann method to multiphase systems. However, there is a lack of models capable of simulating multicomponent multiphase fluids with partial miscibility. In addition, existing models cannot be generalized to honor thermodynamic information provided by any multicomponent equation of state of choice. In this paper, we introduce a free energy Lattice Boltzmann model where the forcing term is determined by the fugacity of the species, the thermodynamic property that connects species partial pressure to chemical potential calculations. By doing so, we are able to carry out multicomponent multiphase simulations of partially miscible fluids and generalize the methodology for use with any multicomponent equation of state of interest. We test this fugacity-based Lattice Boltzmann method for the cases of vapor-liquid equilibrium for two and three-component mixtures in various temperature and pressure conditions. We demonstrate that the model is able to reliably reproduce phase densities and compositions as predicted by multicomponent thermodynamics and can reproduce different characteristic pressure-composition and temperature-composition envelopes with a high degree of accuracy. We also demonstrate that the model can offer accurate predictions under dynamic conditions.
Published: 2022

15. Clasificación de los valores de rango de movimiento de la extremidad inferior en jugadores de fútbol sala

Author: A. Cejudo, P. Sainz de Baranda, F. Ayala, and F. Santonja
Subjects: Flexibilidad, rango de movimiento, condición física, deportes., Sports, GV557-1198.995
Abstract: Objetivo: Clasificar los valores de flexibilidad de la extremidad inferior en jugadores de la 2ª División de la Liga Nacional de fútbol sala. Método: 60 jugadores fueron valorados mediante la versión básica del protocolo ROM-SPORT. Se realizó un análisis descriptivo y por percentiles para clasificarlos valores de los siete movimientos evaluados. Resultados y conclusión: El presente estudio define el perfil normal de flexibilidad de la extremidad inferior en un rango de valores entre 8-17º para la extensión de cadera, 39-45º para la flexión de tobillo con rodilla extendida, 40-47º para la flexión de tobillo con rodilla flexionada, 42-47º para la abducción de cadera, 76-96º para la flexión de cadera con rodilla extendida, 116-139º para la flexión de rodilla y 141-147º para la flexión de cadera. Valores superiores a este rango se pueden considerar dentro del perfil óptimo mientras que valores inferiores se pueden considerar dentro del perfil limitado.
Published: 2017
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16. Procedimientos de exploración y valores de referencia del rango de movimiento de la abducción de la cadera en deportistas. ¿Una herramienta en la prevención de lesiones?

Author: A. Cejudo, P. Sainz de Baranda, F. Santonja, and F. Ayala
Subjects: rango de movimiento, flexibilidad, abducción de la cadera, deporte., Sports, GV557-1198.995
Abstract: El rango de movimiento limitado de la abducción de la cadera por una menor extensibilidad o cortedad de los aductores predispone a ciertas lesiones deportivas. Las pruebas angulares de la Abducciónde la Caderacon Pierna Recta (ABPR) y la Abducción de la Cadera en Flexión (ABF) deben incluirse en cualquier evaluación deportiva músculo-esquelética. La utilización de ambas pruebas exploratorias permitirá evaluar específicamente la extensibilidad aductora. Para la medición del rango será necesario el uso de un goniómetro de rama larga y de un inclinómetro con varilla telescópica. De manera general, se han encontrado elevados valores de fiabilidad relativa y absoluta en el test ABPR. Por el contrario, no se han encontrado estudios que analicen la fiabilidad del test ABF.
Published: 2016
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17. Potential of atmospheric pressure ionization sources for the analysis of free fatty acids in clinical and biological samples by gas chromatography-mass spectrometry

Author: Paul E. Görs, Pia Wittenhofer, Juan F. Ayala-Cabrera, and Sven W. Meckelmann
Subjects: Plasma, Atmospheric Pressure, Fatty Acids, Chemie, Fatty Acids, Nonesterified, Biochemistry, Gas Chromatography-Mass Spectrometry, Analytical Chemistry
Abstract: Because of the central role of fatty acids in biological systems, their accurate quantification is still important. However, the impact of the complex matrix of biologically and clinically relevant samples such as plasma, serum, or cells makes the analysis still challenging, especially, when free non-esterified fatty acids have to be quantified. Here we developed and characterized a novel GC–MS method using pentafluorobenzyl bromide as a derivatization agent and compared different ionization techniques such as atmospheric pressure chemical ionization (APCI), atmospheric pressure chemical photoionization (APPI), and negative ion chemical ionization (NICI). The GC-APCI-MS showed the lowest limits of detection from 30 to 300 nM for a broad range of fatty acids and a similar response for various fatty acids from a chain length of 10 to 20 carbon atoms. This allows the number of internal standards necessary for accurate quantification to be reduced. Moreover, the use of pentafluorobenzyl bromide allows the direct derivatization of free fatty acids making them accessible for GC–MS analysis without labor-intense sample pretreatment.
Published: 2022

18. CLINICAL PRESENTATION OF PSORIASIS

Author: F. Ayala
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: SUMMARY Psoriasis is a chronic, inflammatory disease affecting 1-3% of the world’s population. Joints can be affected in up to 30% of patients. About one third of patients have either severe or moderate (involving more than 10% of body surface area) disease. Patients affected with extensive psoriasis have an impaired quality of life. Psoriasis has a large spectrum of clinical features and evolution, so no complete agreement on the classification of the clinical variants exists. Plaque psoriasis is the commonest form (more than 80% of affected patients). The course of plaque psoriasis varies. Spontaneous resolution is possible, but rarely occurs. Plaques tend to remain static or slowly enlarge. Flexural (inverse, intertriginous) psoriasis manifests with lesions thinner than those of plaque form with no or minimal scaling, and is localized in the skin folds. Guttate (eruptive) psoriasis has frequently a sudden onset and frequently appears abruptly after a bacterial or viral febrile episode of inflammation of the upper ways. Pustular and erythrodermic psoriasis are the most severe clinical variants. In the diffuse pustular form recurrent episodes of fever occur, followed by new outbreaks of pustules. Erythrodermic psoriasis corresponds to the generalized form of the disease. The entire skin is bright red and is covered by superficial scales. Fatigue, myalgia, shortness of breath, fever and chills may also occur. In sebopsoriasis (seborrheic dermatitis + psoriasis) the lesions tend to occur at the same sites as seborrheic dermatitis; greasy scales predominate, but silvery scales can be found in some areas. Nail psoriasis shows various features: nail pits; oil spots; subungual hyperkeratosis; onycholysis. Rare forms include psoriasis circinata, lip psoriasis and oral psoriasis. Differential diagnosis includes many other dermatological conditions. Key words: Psoriasis, nail, quality of life
Published: 2011
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19. IMMUNOPATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS AND PHARMACOLOGICAL PERSPECTIVES

Author: A. Genovese, G.C. Marone, F. Ayala, S. Loffredo, and G. Marone
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Psoriasis and psoriatic arthritis are chronic inflammatory disorders resulting from a combination of genetic and environmental factors, though the precise causal agents have not yet been identified. The immune system has a major role in their development and the possibility exists that self antigens or antigens from microbial agents, or microbial superantigens initiate a vigorous immune response. Different subsets of T-lymphocytes and dendritic cells, mast cells and granulocytes participate in the pathogenesis and several cytokines and chemokines have been identified in tissue lesions. TNF-α is a key proinflammatory cytokine with important pathogenetic role in psoriasis and psoriatic arthritis. Evidence from clinical trials targeting the TNF-α–TNF-α-receptor supports a central role for this cytokine in the pathogenesis of psoriasis and psoriatic arthritis. Angiogenesis is a prominent early event in lesional psoriatic skin and in synovial membrane psoriatic arthritis. Future potential targets in the treatment of these disorders include biologic agents aimed at blockade of other cytokines, chemokines and angiogenic factors. Key words: Psoriasis, psoriatic arthritis, immunity
Published: 2011
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20. Crecimiento, Mortalidad Y Sobrevivencia Del Charal Chirostoma humboldtianum (Atherinopsidae) En El Embalse San Miguel Arco, Soyaniquilpan, Estado De México

Author: R. Sánchez-Merino, M. Díaz-Zaragoza, N. A. Navarrete-Salgado, M. L. García-Martínez, F. Ayala-Niño, and M. D. Flores-Aguilar
Subjects: Forestry, SD1-669.5
Abstract: Se evaluó el crecimiento individual en longitud y peso, la mortalidad y supervivencia del charal Chirostoma humboldtianum en el mes de abril de 2005, en el embalse San Miguel Arco, localizado entre 99° 32 10 longitud oeste y 20° 24 42 latitud norte. Se establecieron cinco estaciones de muestreo, en cada una se capturaron a los charales mediante un chinchorro de 30.0 m x 2.0 m y 8.0 mm de luz de malla. Se estimó la longitud máxima por el método de Ford Walford, las constantes de modelo de crecimiento, el factor de condición a partir de la relación peso-longitud, el tipo de crecimiento (y su prueba t-student), la tasa de mortalidad y de sobrevivencia. La longitud máxima fue de 8.9760 cm, la tasa de crecimiento de -0.5230, el peso máximo 10.3689 g, el factor de condición de 1.13 %, el tipo de crecimiento es isométrico 3.10 (t
Published: 2006

21. Bucindolol Decreases Atrial Fibrillation Burden in Patients With Heart Failure and the ADRB1 Arg389Arg Genotype

Author: Jonathan P. Piccini, Christopher Dufton, Ian A. Carroll, Jeff S. Healey, William T. Abraham, Yaariv Khaykin, Ryan Aleong, Steven K. Krueger, William H. Sauer, Stephen B. Wilton, Michiel Rienstra, Dirk J. van Veldhuisen, Inder S. Anand, Michel White, A. John Camm, Paul D. Ziegler, Debra Marshall, Michael R. Bristow, Stuart J. Connolly, F Ayala-Paredes, A Bakbak, ML Bernier, DH Birnie, B Coutu, E Crystal, MW Deyell, KM Dyrda, MC Hartleib, ZW Laksman, P Leong-Sit, CA Morillo, AS Pandey, F Philippon, S Vizel, P Andréka, Z Csanadi, GZ Duray, T Forster, G Kerkovits, B Merkely, AC Nagy, T Simor, D Czarnecka, JD Kasprzak, WJ Musial, G Raczak, J Szachniewicz, JK Wranicz, S Apostolović, S Hinić, V Miloradović, D Simić, GJ Milhous, A Oomen, TJ Romer, LM van Vijk, PB Adamson, JD Allred, N Amjadi, MM Bahu, AJ Bank, AE Berman, MA Bernabei, RS Bhagwat, L Borgatta, AJ Buda, RT Cole, JL Collier, SJ Compton, O Costantini, MR Costanzo, IM Dauber, MP Donahue, I Dor, GF Egnacyzk, EJ Eichhorn, CC Eiswirth, S Emani, GA Ewald, RC Forde-McLean, MD Gelernt, DE Haines, CA Henrikson, JM Herre, B Herweg, L Ilkhanoff, LR Jackson, A Lala, R Lo, B London, BD Lowes, JA Mackall, V Malhotra, FA McGrew, S Murali, A Natale, KR Nilsson, J Okolo, MV Perez, RS Phang, R Ranjan, MY Rashtian, MJ Ross, SM Samii, T Shinn, MB Shoemaker, SA Strickberger, VN Tholakanahalli, A Tzur, PJ Wang, LT Younis, and Cardiovascular Centre (CVC)
Subjects: medicine.medical_specialty, medicine.medical_treatment, Population, DRONEDARONE, heart failure, 030204 cardiovascular system & hematology, Cardioversion, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, Sinus rhythm, atrial fibrillation, 030212 general & internal medicine, education, Metoprolol, RISK, education.field_of_study, business.industry, Bucindolol, Atrial fibrillation, medicine.disease, metoprolol, Dronedarone, chemistry, atrial flutter, Cardiology, TRIAL, Cardiology and Cardiovascular Medicine, business, Atrial flutter, bucindolol, medicine.drug
Abstract: Background: Bucindolol is a genetically targeted β-blocker/mild vasodilator with the unique pharmacological properties of sympatholysis and ADRB1 Arg389 receptor inverse agonism. In the GENETIC-AF trial (Genotype-Directed Comparative Effectiveness Trial of Bucindolol and Toprol-XL for the Prevention of Symptomatic Atrial Fibrillation/Atrial Flutter in Patients With Heart Failure) conducted in a genetically defined heart failure population at high risk for recurrent atrial fibrillation (AF), similar results were observed for bucindolol and metoprolol succinate for the primary end point of time to first AF event; however, AF burden and other rhythm control measures were not analyzed. Methods: The prevalence of ECGs in normal sinus rhythm, AF interventions for rhythm control (cardioversion, ablation, and antiarrhythmic drugs) and biomarkers were evaluated in the overall population entering efficacy follow-up (N=257). AF burden was evaluated for 24 weeks in the device substudy (N=67). Results: In 257 patients with heart failure, the mean age was 65.6±10.0 years, 18% were female, mean left ventricular ejection fraction was 36%, and 51% had persistent AF. Cumulative 24-week AF burden was 24.4% (95% CI, 18.5–30.2) for bucindolol and 36.7% (95% CI, 30.0–43.5) for metoprolol (33% reduction, P P P P =0.011). Reductions in plasma norepinephrine ( P =0.038) and NT-proBNP (N-terminal pro B-type natriuretic peptide; P =0.009) were also observed with bucindolol compared with metoprolol. Conclusions: Compared with metoprolol, bucindolol reduced AF burden, improved maintenance of sinus rhythm, and lowered the need for additional rhythm control interventions in patients with heart failure and the ADRB1 Arg389Arg genotype. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01970501.
Published: 2021

22. PRODUCCIÓN DE PLANTAS DE TOMATE Y CHILE APLICANDO PACLOBUTRAZOL AL FOLLAJE

Author: TJ Velázquez-Alcaraz, L Partida-Ruvalcaba, B Acosta-Villegas, and F Ayala-Tafoya
Subjects: Retardar, dosis, hojas, variedad, altura, Agriculture
Abstract: Esta investigación se hizo para determinar el efecto que produce el paclobutrazol (PBZ) en la altura de plantas de chile, conocer las dosis más adecuadas para retardar crecimiento y producir plantas que por su baja altura resistan más a fuertes vientos y lluvias después de su trasplante en campo, y establecer la mejor etapa fenológica de tomate para retardar crecimiento. La siembra de chile fue hecha el 8 de octubre y la de tomate el 30 de noviembre de 2003, en charolas de poliestireno con 200 cavidades. Las unidades experimentales incluyeron 30 plantas, excepto el testigo que tuvo las 20 restantes en la charola. Los tratamientos fueron 0 (testigo), 100, 150, 200, 250, 300 y 350 mg L-1 de PBZ. Cada dosis fue aplicada mediante 12 disparos con un atomizador, en plantas de chile con dos hojas verdaderas y en tomate con dos, cuatro y seis hojas. Con cada cultivar se estableció un experimento que fue manejado sólo con los riegos necesarios y una aplicación de 1.15 g N L-1 de agua. La altura de plantas fue medida desde la base del tallo hasta la yema apical, 23 días después de la aplicación de PBZ.
Published: 2014
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23. Mammalian Target of Rapamycin in Inflammatory Skin Conditions

Author: A. Balato, R. Di Caprio, S. Lembo, M. Mattii, M. Megna, M. Schiattarella, G. Tarantino, N. Balato, F. Ayala, and G. Monfrecola
Subjects: Medicine
Abstract: The conserved serine/threonine kinase mammalian target of rapamycin (mTOR) is a major regulator of survival growth, proliferation and motility, in response to mitogens, energy and nutrient levels. Dysregulation of mTOR pathway has been observed in various inflammatory or neoplastic human diseases. To assess the potential involvement of mTOR in some of the most common inflammatory skin diseases, and its interaction with other inflammatory mediators, we investigated mTOR expression in psoriasis, allergic contact dermatitis (ACD) and atopic dermatitis (AD). mTOR gene expression was assessed in the following conditions: i) skin biopsies from 15 patients affected by psoriasis, 5 patients with ACD, 5 patients with AD and 3 patients with EGFR-inhibitor-induced skin rash; ii) in immortalized keratinocytes HaCaT, primary human keratinocytes (KCs) and full thickness skin organ cultures, incubated with tumor necrosis factor (TNF)-α, interleukin (IL) 17A or their combination; iii) in HaCaT cells stimulated with ultraviolet (UV)B; iv) in skin biopsies from 5 psoriatic patients before and after 16 weeks of anti-TNF-α therapy; mTOR expression was also evaluated through immunohistochemistry in lesional and non-lesional skin samples from 5 psoriatic patients. Moreover, mTOR major up-stream and down-stream regulator gene expression was assessed in skin biopsies from 15 patients affected by psoriasis, 5 patients with ACD, 5 patients with AD and 3 patients with EGFR-inhibitor-induced skin rash. All analyzed skin diseases showed an increase of mTOR gene expression whereas mTOR up-stream negative regulators were reduced or not enhanced in all of them. mTOR was strongly expressed in all epidermal layers of lesional and non-lesional psoriatic skin. Conversely, pro-inflammatory conditions, in vitro , were not able to increase mTOR levels, except for UVB. Similarly, anti-TNF-α therapy was not able to reduce mTOR gene expression in patients with psoriasis. Our study provides evidence that mTOR is involved in cutaneous inflammatory process, but through a signalling not directly dependent from Th1-Th17 pathway.
Published: 2014
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24. Consensus of the Spanish society of laboratory medicine and the Spanish society of medical oncology on the methodology and criteria for evaluation of circulating tumour markers in breast cancer

Author: T. Quintanar-Verdúguez, E. Galve-Calvo, F. Ayala de la Peña, J. M. Augé-Fradera, S. de la Cruz, B. Ortiz-Muñoz, J. Trapé-Pujol, Jose D Santotoribio, J. García-Gómez, and Á. González-Hernández
Subjects: 0301 basic medicine, Oncology, p53, Cancer Research, medicine.medical_specialty, Medical laboratory, Breast Neoplasms, Disease, Special Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, Biomarkers, Tumor, Medicine, Humans, Hematologic Tests, business.industry, Tumor suppressor, General Medicine, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Carcinoembryonic antigen, Female, business, Biomarkers
Abstract: The measurement of circulating tumour markers (TMs) for the diagnosis or monitoring of breast cancer has sometimes been considered of limited utility. In addition to the overinterpretation of irrelevant changes in marker levels, the characteristics of the patient, the disease or other pathologies that can modify them are often not considered in their evaluation. On the other hand, there are recent data on the relationship of TMs with molecular subtypes and on their prognostic value, the knowledge of which may improve their clinical utility. This consensus article arises from a collaboration between the Spanish Society of Laboratory Medicine (SEQCML) and the Spanish Society of Medical Oncology (SEOM). It aims to improve the use and interpretation of circulating TMs in breast cancer. The text summarizes the current knowledge and available evidence on the subject and proposes a series of recommendations mainly focussed on the indication, the frequency of testing and the factors that should be considered for correctly interpreting changes in the levels of TMs.
Published: 2021

25. 2142P Criteria for the choice of therapeutic ceiling in the hospitalized oncology patient: Healthcare impact of the multidisciplinary committee with the Intensive Care Unit (ICU)

Author: García, M.E. Guirao, Canovas, M. Sanchez, Saura, A. Sanchez, Luis, S. Montenegro, Ivars, M.A., Boluda, N. Blaya, Fernández, N. Alonso, Quintana, E. Martínez, García, M. Cerón, García, L. López, Delis, P.S. Bayoumy, Alcaraz, A. Carrillo, and de la Pena, F. Ayala
Published: 2023
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26. Rango de movimiento de la extremidad inferior en atletas de duatlón

Author: A. Cejudo, I. Ruiz, P. Sainz de Baranda, F. Ayala, and F. Santoja
Subjects: flexibilidad, rango de movimiento, condición física, deportes, Sports, GV557-1198.995
Abstract: El objetivo de este estudio fue valorar la flexibilidad de la musculatura de la extremidad inferior en una muestra de atletas sénior de duatlón. Para ello, se evaluó el rango de movimiento de las principales articulaciones. 15 atletas (edad: 32,7±7,85 años; peso: 67,1±4,8 Kg; talla: 172,9±2,8 cm) tomaron parte en este estudio. Se valoró la flexibilidad de los principales grupos musculares de la extremidad inferior (gemelo, sóleo, isquiosurales, cuádriceps, psoas iliaco, glúteo y aductores), a través de 7 pruebas de rango de movimiento pasivo máximo. Los resultados muestran los siguientes valores medios: 10,4º para el psoas-iliaco, 40,3º para el gemelo, 47,3º para el sóleo, 50,7º para los aductores, 82,5º para la musculatura isquiosural, 116,7º para el cuádriceps y 145,9º para el glúteo. Desequilibrios musculares no fueron encontrados entre ambos lados corporales.
Published: 2013
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27. Insulin-like Growth Factor-1, Psoriasis, and Inflammation: A Ménage à Trois?

Author: S. Savastano, N. Balato, F. Gaudiello, C. Di Somma, V. Brancato, A. Colao, F. Ayala, and G. Tarantino
Subjects: Medicine
Abstract: Psoriatic patients have an accumulation of metabolic syndrome (MS) and cardiovascular diseases (CVD), likely mediated by systemic inflammation, and exhibiting low circulating levels of insulin-like growth factor (IGF)-I, a marker of MS and CVD in the general population. The aim of this study is to determine the association of IGF-I and inflammation, and to assess the cardio-metabolic risk calculating the visceral adiposity index (VAI), in a group of psoriatic patients without MS. IGF-I, fibrinogen, C-reactive protein (CRP), and interleukin (IL)-6 levels were determined in 20 patients with moderate to severe psoriasis (age range 23–77 yrs) without MS, according to criteria of the National Cholesterol Education Program's Adult Panel III (ATP III), and 20 age- and BMI-matched controls. The standard deviation score (SDS) of IGF-I levels according to age (zSDS), the homeostasis model assessment of insulin resistance (HOMA-IR), the whole-body insulin sensitivity index (ISI), and VAI were also calculated. Psoriasis Area and Severity Index (PASI) mean value was 17.8±11. HDL cholesterol and IGF-I zSDS values were lower (p
Published: 2011
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28. Effect of active stretching on hip flexion range of motion: 15 versus 30 seconds

Author: F. Ayala and P. Sainz de Baranda
Subjects: Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract: The main purpose of the present study was to examine the efficacy of 12-weeks active stretching program to improve hip flexion range of motion in young adults, as son as evaluate the efficacy of two different stretching durations: 15 and 30 second. A total of 82 subjects young adults volunteer (57 men and 25 women) were the participants in this study. The participants were distributed by means of counterbalance in two stretching groups: a first group of 15 seconds of stretching duration (n=35), a second group with 30 seconds of stretching duration (n=47). Straight leg raise test (SLR). Was used to assess the hip flexion range of motion. Results showed that the active stretching technique was effective to increased hamstring flexibility independently of the stretching duration (p0,05). Conclusion: The active stretching technique is effective to improve hip flexion range of motion, being equal of effective 15 and 30 seconds of stretching duration. Key Words:Hamstring, Flexibility, Range of motion, Active Stretching, Stretching duration.
Published: 2010

29. Isotropy and spurious currents in pseudo-potential multiphase lattice Boltzmann models

Author: Cheng Peng, Luis F. Ayala, Lian-Ping Wang, and Orlando Ayala
Subjects: Physics, General Computer Science, Interface (Java), Isotropy, Multiphase flow, General Engineering, Lattice Boltzmann methods, Fluid Dynamics (physics.flu-dyn), FOS: Physical sciences, Mechanics, Physics - Fluid Dynamics, Computational Physics (physics.comp-ph), 01 natural sciences, 010305 fluids & plasmas, law.invention, 010101 applied mathematics, law, 0103 physical sciences, Point (geometry), 0101 mathematics, Current (fluid), Hydrostatic equilibrium, Spurious relationship, Physics - Computational Physics
Abstract: The spurious currents observed in multiphase flow simulations with pseudo-potential lattice Boltzmann (LB) models are usually understood to be the result of the lack of isotropy of the model-generated interaction force between phases. Remedies have been proposed to utilize larger stencils to compute the interaction force with higher orders of isotropy. In this document, we point out the incompleteness in the current understanding and propose a new consistent implementation to more effectively suppress the spurious currents. We also demonstrate theoretically that certain low-level spurious currents cannot be eliminated by increasing isotropy if the local hydrostatic balance inside the diffuse interface is not established in the LB models.
Published: 2019

30. Seronegative spondyloarthropathies and allergic diseases in patients with ulcerative colitis

Author: F. Manguso, A. D’Arienzo, C. Astarita, F.P. D’Armiento, D. Gargano, R. Peluso, T. Staiano, F. Ayala, G. Mazzacca, and R. Scarpa
Subjects: Medicine, Internal medicine, RC31-1245
Abstract: Seronegative spondyloarthropathy (SpA) and allergic diseases are frequently observed in Ulcerative Colitis (UC). The aim of this study was to evaluate possible relationships between SpA, allergic contact dermatitis (ACD) and IgE-mediated allergic disease (AD) in patients with UC. Fifty consecutive UC patients were graded with clinical, endoscopic and histologic activity scores and classified on the basis of Rachmilewitz and Truelove & Richard criteria. The rheumatologic evaluation included history and physical examination. Axial and peripheral joint involvement was confirmed by radiographic and scintiscan examination. SpA was diagnosed according to the ESSG criteria. The allergologic evaluation included personal history of allergy, prick and patch exposition to airborne, food and contact allergens. AD was confirmed by specific provocation tests, while ACD was determined by using the European Standard Series. Fifty healthy subjects served as controls. Fourteen patients (28%) and 1 control subject (2%) showed SpA (p
Published: 2002
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31. MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

Author: Pellegrini, C. Botta, F. Massi, D. Martorelli, C. Facchetti, F. Gandini, S. Maisonneuve, P. Avril, M.-F. Demenais, F. Bressac-de Paillerets, B. Hoiom, V. Cust, A.E. Anton-Culver, H. Gruber, S.B. Gallagher, R.P. Marrett, L. Zanetti, R. Dwyer, T. Thomas, N.E. Begg, C.B. Berwick, M. Puig, S. Potrony, M. Nagore, E. Ghiorzo, P. Menin, C. Manganoni, A.M. Rodolfo, M. Brugnara, S. Passoni, E. Sekulovic, L.K. Baldini, F. Guida, G. Stratigos, A. Ozdemir, F. Ayala, F. Fernandez-de-Misa, R. Quaglino, P. Ribas, G. Romanini, A. Migliano, E. Stanganelli, I. Kanetsky, P.A. Pizzichetta, M.A. García-Borrón, J.C. Nan, H. Landi, M.T. Little, J. Newton-Bishop, J. Sera, F. Fargnoli, M.C. Raimondi, S. Alaibac, M. Ferrari, A. Valeri, B. Sicher, M. Mangiola, D. Nazzaro, G. Tosti, G. Mazzarol, G. Giudice, G. Ribero, S. Astrua, C. Mazzoni, L. Orlow, I. Mujumdar, U. Hummer, A. Busam, K. Roy, P. Canchola, R. Clas, B. Cotignola, J. Monroe, Y. Armstrong, B. Kricker, A. Litchfield, M. Tucker, P. Stephens, N. Switzer, T. Theis, B. From, L. Chowdhury, N. Vanasse, L. Purdue, M. Northrup, D. Rosso, S. Sacerdote, C. Leighton, N. Gildea, M. Bonner, J. Jeter, J. Klotz, J. Wilcox, H. Weiss, H. Millikan, R. Mattingly, D. Player, J. Tse, C.-K. Rebbeck, T. Walker, A. Panossian, S. Setlow, R. Mohrenweiser, H. Autier, P. Han, J. Caini, S. Hofman, A. Kayser, M. Liu, F. Nijsten, T. Uitterlinden, A.G. Kumar, R. Bishop, T. Elliott, F. Lazovich, D. Polsky, D. Hansson, J. Pastorino, L. Gruis, N.A. Bouwes Bavinck, J.N. Aguilera, P. Badenas, C. Carrera, C. Gimenez-Xavier, P. Malvehy, J. Puig-Butille, J.A. Tell-Marti, G. Blizzard, L. Cochrane, J. Branicki, W. Debniak, T. Morling, N. Johansen, P. Mayne, S. Bale, A. Cartmel, B. Ferrucci, L. Pfeiffer, R. Palmieri, G. Kypreou, K. Bowcock, A. Cornelius, L. Council, M.L. Motokawa, T. Anno, S. Helsing, P. Andresen, P.A. Guida, S. Wong, T.H. IMI Study Group GEM Study Group M-SKIP Study Group
Abstract: Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. We gathered phenotypic and genetic data from children or adolescents diagnosed with sporadic single-primary cutaneous melanoma at age 20 years or younger, adult patients with sporadic single-primary cutaneous melanoma diagnosed at age 35 years or older, and healthy adult individuals as controls. We calculated odds ratios (ORs) for childhood and adolescent melanoma associated with MC1R variants by multivariable logistic regression. Subgroup analysis was done for children aged 18 or younger and 14 years or younger. Findings: We analysed data from 233 young patients, 932 adult patients, and 932 healthy adult controls. Children and adolescents had higher odds of carrying MC1R r variants than did adult patients (OR 1·54, 95% CI 1·02–2·33), including when analysis was restricted to patients aged 18 years or younger (1·80, 1·06–3·07). All investigated variants, except Arg160Trp, tended, to varying degrees, to have higher frequencies in young patients than in adult patients, with significantly higher frequencies found for Val60Leu (OR 1·60, 95% CI 1·05–2·44; p=0·04) and Asp294His (2·15, 1·05–4·40; p=0·04). Compared with those of healthy controls, young patients with melanoma had significantly higher frequencies of any MC1R variants. Interpretation: Our pooled analysis of MC1R genetic data of young patients with melanoma showed that MC1R r variants were more prevalent in childhood and adolescent melanoma than in adult melanoma, especially in patients aged 18 years or younger. Our findings support the role of MC1R in childhood and adolescent melanoma susceptibility, with a potential clinical relevance for developing early melanoma detection and preventive strategies. Funding: SPD-Pilot/Project-Award-2015; AIRC-MFAG-11831. © 2019 Elsevier Ltd
Published: 2019

32. Reservoir Engineering Models: Analytical and Numerical Approaches

Author: Turgay Ertekin, Luis F. Ayala, Turgay Ertekin, and Luis F. Ayala
Abstract: Develop, build, and deploy accurate mathematical models for hydrocarbon reservoirs This practical resource discusses the construction of reservoir models and the implementation of these models in both forward and inverse modes using numerical, analytical, empirical, and artificial intelligence techniques. Written by a pair of experts in the field, Reservoir Engineering Models: Analytical and Numerical Approaches clearly explains the complicated building processes of mathematical models and lays out cutting-edge solution protocols. Advanced chapters teach the assembly of complex physical processes using principles of physics, thermodynamics and mathematics. You will learn to optimize decision-making processes applicable to the management of field development and extraction activities. Coverage includes: •An introduction to reservoir engineering models•Mathematics of reservoir engineering•Reservoir engineering fundamentals•Hydrocarbon fluid models and thermodynamics•Reservoir engineering transport equations•Analytical and numerical reservoir engineering solutions•Proxy and hybrid models in reservoir engineering
Published: 2018

33. Predicting serious complications in patients with cancer and pulmonary embolism using decision tree modelling: the EPIPHANY Index

Author: O. Madridano, F. Ayala de la Peña, M. Martín, Vicente Vicente, Diego Varona, J. Plasencia, L. Faez, I. de la Haba, Carmen Beato, Mariana Benegas, Alberto Carmona-Bayonas, M. Antonio, D. Calvo-Temprano, Avinash Ramchandani, Eduardo Castanon, M. P. Solis, Francisco J. Fenoy, M. Biosca, Carme Font, Pablo Javier Marchena, Manuel Anguita Sánchez, Remedios Otero, and P. Jiménez-Fonseca
Subjects: Oncology, Male, Cancer Research, pulmonary embolism, 030204 cardiovascular system & hematology, clinical decision rule, Severity of Illness Index, 0302 clinical medicine, Neoplasms, Health Status Indicators, Registries, EPIPHANY Index, Càncer, risk, Cancer, Cervical cancer, Embòlia pulmonar, Mortality rate, incidental, Middle Aged, Prognosis, Pulmonary embolism, Survival Rate, 030220 oncology & carcinogenesis, Area Under Curve, Female, medicine.medical_specialty, Risk Assessment, Decision Support Techniques, 03 medical and health sciences, Internal medicine, Severity of illness, medicine, cancer, Humans, Survival rate, Neoplasm Staging, business.industry, Decision Trees, medicine.disease, mortality, Confidence interval, Risk Estimate, Clinical Study, business, Complication, prognostic scales, Follow-Up Studies
Abstract: Background: Our objective was to develop a prognostic stratification tool that enables patients with cancer and pulmonary embolism (PE), whether incidental or symptomatic, to be classified according to the risk of serious complications within 15 days. Methods: The sample comprised cases from a national registry of pulmonary thromboembolism in patients with cancer (1075 patients from 14 Spanish centres). Diagnosis was incidental in 53.5% of the events in this registry. The Exhaustive CHAID analysis was applied with 10-fold crossvalidation to predict development of serious complications following PE diagnosis. Results: About 208 patients (19.3%, 95% confidence interval (CI), 17.1-21.8%) developed a serious complication after PE diagnosis. The 15-day mortality rate was 10.1%, (95% CI, 8.4-12.1%). The decision tree detected six explanatory covariates: Hestia-like clinical decision rule (any risk criterion present vs none), Eastern Cooperative Group performance scale (ECOG-PS; = 2), O-2 saturation (= 90%), presence of PE-specific symptoms, tumour response (progression, unknown, or not evaluated vs others), and primary tumour resection. Three risk classes were created (low, intermediate, and high risk). The risk of serious complications within 15 days increases according to the group: 1.6, 9.4, 30.6%; P
Published: 2017

34. Prognostic evaluation of febrile neutropenia in apparently stable adult cancer patients

Author: Manuel Canteras, M L Gonzálvez, A Navarrete, F. Ayala de la Peña, Alberto Carmona-Bayonas, Enrique Gonzalez-Billalabeitia, Vicente Vicente, and Juan de la Cámara Gómez
Subjects: Adult, Male, Cancer Research, Chronic bronchitis, medicine.medical_specialty, Neutropenia, Adolescent, Fever, Sensitivity and Specificity, Young Adult, Internal medicine, Neoplasms, Medicine, prognostic model, Humans, Young adult, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Case-control study, Cancer, Retrospective cohort study, Middle Aged, medicine.disease, Prognosis, apparently stable patients, Surgery, febrile neutropenia, Oncology, Heart failure, Case-Control Studies, Clinical Study, Disease Progression, Female, business, Febrile neutropenia
Abstract: Background: Predictive models to identify low-risk febrile neutropenia (FN) have been developed with heterogeneous samples, which included stable and unstable patients, solid tumours, acute leukaemia and bone marrow transplantation. These models fail to recognise 5–15% of cases with unexpected complications, and literature specifically addressing apparently stable patients (ASPs) is scarce. Methods: We reviewed 861 episodes of FN in outpatients with solid tumours, including 692 (80%) episodes with apparent clinical stability. We aimed to investigate the prognosis of this latter group and explore the possibility of stratifying it according to the presenting features. A case–control study was performed and the MASCC index was evaluated. Results: The rates of complications and bacteraemia in ASPs were 7.3% and 6.2%, respectively. The MASCC index yielded a low sensitivity to detect complications (36%). Prognostic factors were identified: ECOG performance status ⩾2, chronic bronchitis, chronic heart failure, stomatitis NCI grade ⩾2, monocytes
Published: 2011

35. Effect of active stretching on hip flexion range of motion: 15 versus 30 seconds Efecto del estiramiento activo sobre el rango de movimiento de la flexión de cadera: 15 versus 30 segundos

Author: P. Sainz de Baranda and F. Ayala
Subjects: lcsh:Sports, lcsh:GV557-1198.995, lcsh:Human anatomy, lcsh:Sports medicine, lcsh:RC1200-1245, lcsh:QM1-695
Abstract: The main purpose of the present study was to examine the efficacy of 12-weeks active stretching program to improve hip flexion range of motion in young adults, as son as evaluate the efficacy of two different stretching durations: 15 and 30 second. A total of 82 subjects young adults volunteer (57 men and 25 women) were the participants in this study. The participants were distributed by means of counterbalance in two stretching groups: a first group of 15 seconds of stretching duration (n=35), a second group with 30 seconds of stretching duration (n=47). Straight leg raise test (SLR). Was used to assess the hip flexion range of motion. Results showed that the active stretching technique was effective to increased hamstring flexibility independently of the stretching duration (p0,05). Conclusion: The active stretching technique is effective to improve hip flexion range of motion, being equal of effective 15 and 30 seconds of stretching duration.Key Words:Hamstring, Flexibility, Range of motion, Active Stretching, Stretching duration.El objetivo principal de este estudio fue valorar la eficacia de un programa de estiramientos activos con una duración de 12 semanas para aumentar el rango de movimiento de la flexión de cadera en adultos jóvenes, así como comparar la eficacia de dos duraciones diferentes del estiramiento, 15 y 30 segundos. La muestra estuvo compuesta por un total de 82 sujetos adultos jóvenes sanos voluntarios (57 Hombres y 25 Mujeres). La muestra fue distribuida mediante contrabalanceo en dos grupos de trabajo; un primer grupo de 15 segundos de duración del estiramiento (n=35), un segundo grupo con 30 segundos de duración del mismo (n=47). Para valorar el rango de movimiento de la flexión de cadera se utilizó el test angular elevación de la pierna recta (EPR). Los resultados muestran que la técnica empleada es eficaz para aumentar la flexibilidad isquiosural independientemente de la duración del estiramiento (pp>0,05). Conclusión: la técnica activa es eficaz para aumentar el rango de movimiento de la flexión de la articulación coxo-femoral, siendo igual de efectiva la duración del estiramiento de 15 y 30 segundos.Palabras Clave:Musculatura isquiosural, Flexibilidad, Rango de movimiento, Estiramiento activo, Duración del estiramiento
Published: 2010

36. EFECTO DEL ESTIRAMIENTO ACTIVO SOBRE EL RANGO DE MOVIMIENTO DE LA FLEXIÓN DE CADERA: 15 VERSUS 30 SEGUNDOS

Author: F. Ayala and P. Sainz de Baranda
Subjects: lcsh:Sports, lcsh:GV557-1198.995, lcsh:Human anatomy, lcsh:Sports medicine, lcsh:RC1200-1245, lcsh:QM1-695
Abstract: RESUMEN El objetivo principal de este estudio fue valorar la eficacia de un programa de estiramientos activos con una duración de 12 semanas para aumentar el rango de movimiento de la flexión de cadera en adultos jóvenes, así como comparar la eficacia de dos duraciones diferentes del estiramiento, 15 y 30 segundos. La muestra estuvo compuesta por un total de 82 sujetos adultos jóvenes sanos voluntarios (57 Hombres y 25 Mujeres). La muestra fue distribuida mediante contrabalanceo en dos grupos de trabajo; un primer grupo de 15 segundos de duración del estiramiento (n=35), un segundo grupo con 30 segundos de duración del mismo (n=47). Para valorar el rango de movimiento de la flexión de cadera se utilizó el test angular elevación de la pierna recta (EPR). Los resultados muestran que la técnica empleada es eficaz para aumentar la flexibilidad isquiosural independientemente de la duración del estiramiento (pp>0,05). Conclusión: la técnica activa es eficaz para aumentar el rango de movimiento de la flexión de la articulación coxo-femoral, siendo igual de efectiva la duración del estiramiento de 15 y 30 segundos.Palabras Clave:Musculatura isquiosural, Flexibilidad, Rango de movimiento, Estiramiento activo, Duración del estiramiento ABSTRACT The main purpose of the present study was to examine the efficacy of 12-weeks active stretching program to improve hip flexion range of motion in young adults, as son as evaluate the efficacy of two different stretching durations: 15 and 30 second. A total of 82 subjects young adults volunteer (57 men and 25 women) were the participants in this study. The participants were distributed by means of counterbalance in two stretching groups: a first group of 15 seconds of stretching duration (n=35), a second group with 30 seconds of stretching duration (n=47). Straight leg raise test (SLR). Was used to assess the hip flexion range of motion. Results showed that the active stretching technique was effective to increased hamstring flexibility independently of the stretching duration (p0,05). Conclusion: The active stretching technique is effective to improve hip flexion range of motion, being equal of effective 15 and 30 seconds of stretching duration.Key Words:Hamstring, Flexibility, Range of motion, Active Stretching, Stretching duration.
Published: 2010

37. Evaluation of criteria for genetic study of hereditary breast and ovarian cancer BRCAX families by multigene panel testing

Author: Castillo-Guardiola, V., Sarabia-Meseguer, M.D., Macías-Cerrolaza, J.A., García-Aliaga, Á., Rosado-Jiménez, L., Sánchez-Bermúdez, A.I., Zafra-Poves, M., Moreno-Locubiche, M.Á., Pascual-Gilabert, P., Aliaga-Baño, Á., Noguera-Velasco, J.A., De La Peña, F. Ayala, and Ruiz-Espejo, F.
Published: 2019
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38. The impact of psoriasis on work-related problems: a multicenter cross-sectional survey

Author: Giuliana Gualberti, Nicola Balato, U.d.L. Paparatti, G.V. Romano, R. Merolla, Francesca Sampogna, Concetta Potenza, G. Guida, Paolo Amerio, F. Ayala, Ayala, Fabio, Sampogna, F, Romano, Gv, Merolla, R, Guida, G, Gualberti, G, Paparatti, Ud, Amerio, P, Balato, Nicola, and Potenza, C.
Subjects: Adult, Male, medicine.medical_specialty, Cross-sectional study, media_common.quotation_subject, MEDLINE, Dermatology, Anger, Logistic regression, Work related, Psoriasis Area and Severity Index, Psoriasis, Medicine, Humans, Workplace, media_common, business.industry, Middle Aged, medicine.disease, Infectious Diseases, Cross-Sectional Studies, Physical therapy, Female, business, Psychosocial
Abstract: Background Psoriasis can have cumulative physical and psychosocial effects preventing sufferers from achieving their full-life potential. Few studies have addressed the impact of psoriasis on work-related characteristics. Objective To evaluate the impact of psoriasis on education prospects and work limitations in patients with moderate-to-severe psoriasis. Methods This study was conducted in 29 dermatology centres across Italy. Information was collected by questionnaire during office visits. Results A total of 787 patients (64% male, aged 50 years) completed the questionnaire. At the time of the survey, mean Psoriasis Area and Severity Index (PASI) score and disease duration were 10 and 19 years respectively. Current smokers had higher PASI scores compared to non-smokers (10.8 vs. 9.4, P = 0.02). Plaque psoriasis was the most frequently described (91.2%). Fifty-five percent of patients had limited expectations of career progression. Similarly, in 42% of cases, psoriasis reduced the prospects of improvement in employment status and 35% of patients reported having reduced earning potential. Approximately 60% of patients reported that psoriasis localized to their hands or feet caused work limitations, whilst in about 25%, it caused them to quit their job. Approximately 37% of patients reported having lost between 3–10 work days in the past 3 months due to clinical assessment or treatment. Logistic regression revealed that gender, low standard of education, number of localizations, shame, anger and self-esteem were predictors significantly associated with limitations in work. Conclusions Moderate-to-severe psoriasis has a profound negative impact on the employment capacity of patients in Italy. Psoriasis also contributes to days lost from work, affects job opportunity, career prospects and revenue potential.
Published: 2014

39. P-276 - Raltitrexed as salvage therapy for metastatic colorectal cancer: A multicenter retrospective study

Author: Ghanem, I., Viudez, A., García-Torralba, E., Torres-Tenor, J., Carmona, A., Vera, R., Rodriguez-Salas, N., de la Peña, F. Ayala, Higuera, O., and Feliu, J.
Published: 2018
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40. Psoriatic arthritis 'sine psoriasis' clinical and genetical aspects

Author: R. SCARPA, E. COSENTINI, F. MANGUSO, A. ORIENTE, PELUSO, ROSARIO, M. ATTENO, F. AYALA, A. D’ARIENZO, ORIENTE, PASQUALE, R., Scarpa, E., Cosentini, F., Manguso, A., Oriente, Peluso, Rosario, M., Atteno, F., Ayala, A., D’Arienzo, and Oriente, Pasquale
Subjects: Psoriatic Arthritis “sine psoriasis”, genetical aspects, clinical aspect
Published: 2003

41. Relapsing lichen actinicus successfully treated with cyclosporin

Author: L Gallo, F Ayala, Gallo, L., Ayala, Fabio, and Ayala, F.
Subjects: medicine.medical_specialty, Infectious Diseases, business.industry, medicine, Dermatology, Lichen, business, corticosteroid, cyclosporin, Surgery
Published: 2008

42. statistical evaluation of the persistence of acquired hypersensitivity by standardized patch tests

Author: AYALA, FABIO, F. AYALA, G. LEMBO, C. PATRUNO, G. FABBROCINI, I. NOFRONI, N. MAGLIOCCHETTI, D. SCHENA, A. RAFANELLI, S. SEIDENARI, A. MOTOLESE, G. ANGELINI, Ayala, Fabio, F., Ayala, G., Lembo, C., Patruno, G., Fabbrocini, I., Nofroni, N., Magliocchetti, D., Schena, A., Rafanelli, S., Seidenari, A., Motolese, and G., Angelini
Published: 1996

43. The relationship between lichen ruber planus orale, hepatopathies and hypersensitivity to the components of dental restorations

Author: F, Ayala, S, Matarasso, S, De Rosa, F, Bordone, E, Vaia, N, Balato, Ayala, Fabio, Matarasso, S, De Rosa, S, Bordone, F, Vaia, E, and Balato, Nicola
Subjects: Male, Liver, Biopsy, Liver Diseases, Hypersensitivity, Lichen Planus, Humans, Alanine Transaminase, Female, Aspartate Aminotransferases, Patch Tests, Mouth Diseases, Dentures
Abstract: A group of patients with lichen planus, a pathology affecting the cutis and mucosa which may affect the oral cavity, were studied. All patients underwent laboratory tests to assess hepatic function. Prick tests, using a series of haptens found in materials used in dental reconstruction work, were also performed in 53 patients who possessed dental prostheses. The statistically significant correlation between lichen planus, especially in its erosive form, and hepatic damage is underlined. However, the correlation between sensitivity to the haptens contained in materials for dental reconstruction work and lichen planus was not significant.
Published: 1990

44. 1405P - A Prognostic Model of Survival After First Hospital Discharge of Cancer Patients

Author: Conesa, M.A. Vicente, Fernanadez, A., Zafra, M., De Barrio, P.La Morena, Ballester, I., Garcia-Garre, E., Urrgeo, E., Carmona-Bayonas, A., and Peña, F. Ayala de La
Published: 2014
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45. 915P - Prognostic Value of Multidisciplinar Gynaecological Committe in Ovarian Cancer Patients

Author: García-Martinez, E., Garcia-Garre, E., Garcia-Garcia, T., Vicente, V., and Peña, F. Ayala de La
Published: 2014
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46. The Proton Spectrum in Neutron Beta Decay: First Results with the aSPECT spectrometer.

Author: Baeßler, S., Angerer, H., Guardia, F. Ayala, Borg, M., Eberhardt, K., Glück, F., Heil, W., Konorov, I., Konrad, G., Llopis, N. Luquero, Horta, R. Muñoz, Orlowski, M., Petzoldt, G., Rich, D., Simson, M., Sobolev, Y., Wirth, H. F., and Zimmer, O.
Subjects: NEUTRONS, MATRICES (Mathematics), SPECTROMETERS, NEUTRINOS, PROTONS, STOPPING power (Nuclear physics), NEUTRON beams
Abstract: First measurements with the aSPECT spectrometer have been performed in a beam time at the beam line MEPHISTO of the neutron research reactor FRM-II. In this paper we give a short description of the spectrometer. The data analysis is still underway. © 2006 American Institute of Physics [ABSTRACT FROM AUTHOR]
Published: 2006
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47. Gas-Rate Forecasting in Boundary-Dominated Flow: Constant-Bottomhole-Pressure Decline Analysis by Use of Rescaled Exponential Models.

Author: Zhang, M. and H., L. F. Ayala
Subjects: GAS wells, FLUID flow, EQUATIONS in fluid mechanics
Abstract: The article presents a study conducted by researchers H. Ayala and P. Ye to demonstrate importance of rescaled exponential model for gas-well performance forecasting during boundary-dominated flow (BDF) by using density-based dimensionless parameters. The study demonstrates rescaled exponential equation as rate/time equation which is modeling gas-rate decline in wells.
Published: 2014
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48. Two-phase flow models for thermal behavior interpretation in horizontal wellbores

Author: Ting Dong and Luis F. Ayala
Subjects: Engineering, Steady state, Petroleum engineering, business.industry, Flow (psychology), 02 engineering and technology, Geotechnical Engineering and Engineering Geology, 01 natural sciences, 010305 fluids & plasmas, Interpretation (model theory), General Energy, 020401 chemical engineering, Completion (oil and gas wells), Homogeneous, 0103 physical sciences, Offshore geotechnical engineering, Thermal, Two-phase flow, 0204 chemical engineering, business
Abstract: The interpretation of Distributed Temperature Sensing (DTS) real-time temperature data from downhole is essential to understand wellbore production and production operations management. This paper presents a multi-phase wellbore thermal behavior prediction model for the interpretation of wellbore fluid thermal responses. Based on our previous simulation results on single-phase flow in horizontal wellbores, a two-phase flow model (η s-driven model) is developed for steady-state conditions in the form of homogeneous and drift-flux models applied to both openhole and perforated completion types. Case studies include the examination of water entry thermal effect and gas mixing thermal effect comparing between the two modeling approaches. Results show that the phenomena of water breakthrough and gas blended in oil can be detected from fluids temperature profiles.
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49. A novel assocation between HLA and disease: porphyria cutanea tarda and HLA-AW32

Author: P. Santoianni, DE FELICE, MARIO, F. Ayala, G. Budillon, S. Zappacosta, P., Santoianni, DE FELICE, Mario, F., Ayala, G., Budillon, and S., Zappacosta
Abstract: An association between porphyria cutanea tarda and HLA-AW32 has been put into evidence in a group of 28 unrelated patients. A relative risk of 3.09, with a chi 2 of 4.55 (p less than 0.05) was found, using a 148-member panel of controls.
Published: 1980

50. Oxatomide in the therapy of urticaria

Author: N, Balato, F, Ayala, P, Nappa, G, Lembo, M, Nicora, Balato, Nicola, Ayala, Fabio, Nappa, P, Lembo, G, and Nicora, M.
Subjects: Adult, Male, Adolescent, Urticaria, Histamine H1 Antagonists, Humans, Female, Middle Aged, Piperazines, Follow-Up Studies
Published: 1988

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