Search

Objectives: To compare carotid endarterectomy patch angioplasty (p-CEA) with eversion carotid endarterectomy (e-CEA) and associated risks of early cardio-cerebrovascular complications. Methods: The study was a prospective randomized single-blind trial, monocentric, clinically applicable, descriptive analytical and comparative. From June 2021 to June 2023, 62 consecutive patients with symptomatic and asymptomatic stenosis of the internal carotid artery, admitted to our department and randomized into two groups: carotid endarterectomy with patch angioplasty and eversion carotid endarterectomy. Follow-up for 30 days after surgery. Original Article Results: During surgery e-CEA, 70% patients had an arrhythmia, and 24 hours after 66.7%, seven days after 46.7% and month after 13.3%. During surgery p-CEA, 33.3% patients had an arrhythmia, 24 hours later 33.3%, 7 days after 13.3% and 30 days after 13.3% patients. Statistically significant difference observed during surgery (Fishers p=0.004). One day after the surgery rate of patients with arrhythmia that were treated e-CEA has decreased, but it was still higher than after p-CEA (Fishers p=0.010). Conclusion: The frequency and categorization of postoperative cardiac arrhythmias after eversion carotid endarterectomy, the clinical implications of various postoperative heart rhythm disturbances and their longterm effects on patients need to be further investigate through sufficiently powered randomized controlled studies [ABSTRACT FROM AUTHOR]

Background: Lateral instability of the ankle is one of the most common causes of musculoskeletal ankle injuries. The peroneus longus (PL) and peroneus brevis (PB) contribute to ankle stability. In early rehabilitation, isometric exercises have been selected for improvement of ankle stability. To effectively train the peroneal muscles during eversion, it is important to consider ankle and body posture. Objects: This study aimed to compare activation of the PL, PB, and biceps femoris (BF) muscles during eversion in different ankle postures (neutral [N], plantarflexed [PF]) and body postures (sitting and side-lying). Methods: Thirty healthy individuals with no history of lateral ankle sprains within the last 6 months were included in the study. Maximal isometric strength of eversion and muscle activation were measured simultaneously. Muscle activation at submaximal eversion was divided by the highest value obtained from maximal isometric eversion among the four postures (percent maximal voluntary isometric contraction [%MVIC]). To examine the differences in muscle activation depending on posture, a 2 × 2 repeated measures analysis of variance (ANOVA) was conducted. Results: There were significant interaction effects of ankle and body postures on PL muscle activation and evertor strength (p < 0.05). The PL muscle activation showed a significantly greater difference in the side-lying and PF conditions than in the sitting and N conditions (p < 0.05). Evertor strength was greater in the N compared to the PF condition regardless of body posture (p < 0.05). In the case of PB and BF muscle activation, only the main effects of ankle and body posture were observed (p < 0.05). Conclusion: Among the four postures, the side-lying-PF posture produced the highest muscle activation. The side-lying-PF posture may be preferred for effective peroneal muscle exercises, even when considering the BF muscle.

Ankle destabilizing devices were developed to improve the recruitment of the evertor muscles. Nevertheless, the activity of lower-leg muscles has never been compared to each other during functional tests performed with destabilization. The objectives were i) to compare the electromyographic activity between the lower-leg muscles during four functional tests performed with ankle destabilization, and ii) to determine sex-related differences in neuromuscular activation. Twenty-six healthy volunteers (13 males, 13 females) performed the modified Star Excursion Balance Test (mSEBT), unipedal balance and weight-bearing inversion and eversion tests with a destabilizing device, while recording electromyographic activity of the peroneus longus and brevis, tibialis anterior, gastrocnemius lateralis and gluteus medius. The activity of peroneal muscles was significantly greater than other muscles during all functional tests. Furthermore, the anterior direction of the mSEBT was the one implying the greatest activity of the peroneus longus muscle compared to the posteromedial (p=0.003) or posterolateral (p<0.001) directions. Finally, no significant sex-related differences in neuromuscular activity were reported. This study highlights the effectiveness of the destabilizing device to involve specifically the peroneal muscles when performing various functional tests. This device should be used by clinicians to be more specific to the stabilizers of the ankle joint during functional exercises. [ABSTRACT FROM AUTHOR]

The telencephalon of ray‐finned fishes undergoes eversion, which is very different to the evagination that occurs in most other vertebrates. Ventricle morphogenesis is key to build an everted telencephalon. Thus, here we use the apical marker zona occludens 1 to understand ventricle morphology, extension of the tela choroidea and the eversion process during early telencephalon development of four teleost species: giant danio (Devario aequipinnatus), blind cavefish (Astyanax mexicanus), medaka (Oryzias latipes), and paradise fish (Macroposus opercularis). In addition, by using immunohistochemistry against tubulin and calcium‐binding proteins, we analyze the general morphology of the telencephalon, showing changes in the location and extension of the olfactory bulb and other telencephalic regions from 2 to 5 days of development. We also analyze the impact of abnormal eye and telencephalon morphogenesis on eversion, showing that cyclops mutants do undergo eversion despite very dramatic abnormal eye morphology. We discuss how the formation of the telencephalic ventricle in teleost fish, with its characteristic shape, is a crucial event during eversion. Research highlights: The developmental events that lead to an everted telencephalon in ray‐finned fishes are not well understood. Here we show that the morphology of the telencephalic ventricle is quite similar between five species of teleosts, being a key event during eversion. We also show the transformation that the telencephalon undergoes from 2 to 4/5 days of development, including growth that leads to an expansion along the rostro‐caudal axis and that results in a fully everted telencephalon. Our results support the idea that these two key events, ventricle formation and telencephalon elongation, are at the core of the formation of an everted telencephalon in teleosts. In addition, we show zebrafish cyclops mutants develop an everted telencephalon despite very abnormal neurulation that alters ventricle and eye morphology. Our results provide experimental basis for the only model of eversion based in development data. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Engineering (17264073) is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Most below-knee prostheses are manufactured in Iraq without considering the fast progress in smart prostheses, which can offer movements in the desired directions according to the type of control system designed for this purpose. The proposed design appears to have the advantages of simplicity, affordability, better load distribution, suitability for subjects with transtibial amputation, and viability in countries with people having low socio-economic status. The designed prosthetics consisted of foot, ball, and socket joints, two stepper motors, a linkage system, and an EMG shield. All these materials were available in the local markets in Iraq. The experimental results showed that the maximum range of motion to move the designed prosthetic in the sagittal and frontal planes reached 70% of the healthy foot range of motion relative to the signals of the gastrocnemius muscle of a healthy leg person. The angles that represented the range of motion achieved in various directions at the ankle joint were Dorsiflexion Angle (35˚), Plantar Flexion Angle (25˚), Inversion Angle (20˚), and Eversion Angle (15˚).

Context: Lateral ankle sprains commonly occur in an athletic population and can lead to chronic ankle instability. Objective: To compare ankle strength measurements in athletes who have mechanical laxity and report functional instability after a history of unilateral ankle sprains. Design: Retrospective cohort. Setting: Athletic Training Research Lab. Participants: A total of 165 National Collegiate Athletic Association Division I athletes, 97 males and 68 females, with history of unilateral ankle sprains participated. Main Outcome Measures: Functional ankle instability was determined by Cumberland Ankle Instability Tool scores and mechanical ankle instability by the participant having both anterior and inversion/eversion laxity. Peak torque strength measures, concentric and eccentric, in 2 velocities were measured. Results: Of the 165 participants, 24 subjects had both anterior and inversion/eversion laxity and 74 self-reported functional ankle instability on their injured ankle. The mechanical ankle instability group presented with significantly lower plantar flexion concentric strength at 30°/s (139.7 [43.7] N-m) (P =.01) and eversion concentric strength at 120°/s (14.8 [5.3] N-m) (P= .03) than the contralateral, uninjured ankle (166.3 [56.8] N-m, 17.4 [6.2] N-m, respectively). Conclusion: College athletes who present with mechanical laxity on a previously injured ankle exhibit plantar flexion and eversion strength deficits between ankles. [ABSTRACT FROM AUTHOR]

Abstract Background Although the ankle strategy is important for achieving frontal plane stability during one-leg stance, previously developed powered ankle–foot orthoses (PAFOs) did not involve ankle strategies because of hardware limitations. Weakness of movement in frontal plane is a factor that deteriorates gait stability and increases fall risk so it should not be overlooked in rehabilitation. Therefore, we used PAFO with subtalar joint for frontal plane movement and tried to confirm that the existence of it is important in balancing through clinical experiments. Methods We developed a proportional CoP controller to assist ankle strategy or stabilizing moment and enhance eversion to compensate for the tilting moment with 2 dof PAFO. It was true experimental study, and we recruited seven healthy subjects (30 ± 4 years) who did not experience any gait abnormality participated in walking experiments for evaluating the immediate effect of subtalar joint of PAFO on their gait stability. They walked on the treadmill with several cases of controllers for data acquisitions. Indices of gait stability and electromyography for muscle activity were measured and Wilcoxon signed-rank tests were used to identify meaningful changes. Results We found that subjects were most stable during walking (in terms of largest Lyapunov exponents, p 0.008). The results of the correlation analysis indicate that the actuator of the PAFO enhanced eversion and preserved the location of the CoP in the medial direction so that gait stability was not negatively affected or improved. Conclusions We verified that the developed 2 dof PAFO assists the ankle strategy by compensating for the tilting moment with proportional CoP controller and that wearer can walk in a stable state when the orthosis provides power for reducing muscle activity. This result is meaningful because an ankle strategy should be considered in the development of PAFOs for enhancing or even rehabilitating proprioception. Trial registration 7001988-202003-HR-833-03

Current European guidelines recommend both eversion carotid endarterectomy (CEA) and conventional CEA with routine patch closure, rather than routine primary closure. Polyester and polytetrafluoroethylene (PTFE) have been used as patch material for a long time. More recently, bovine pericardium has been used; however, there are few studies comparing long term results between bovine pericardium and other patch types. The aim of this study was to investigate the short and long term results after CEA depending on surgical technique and patch material. A registry based study on all primary CEAs (n = 9 205) performed for symptomatic carotid artery stenosis in Sweden from July 2008 to December 2019, cross linked with data from the Swedish stroke registry, Riksstroke, and chart review for evaluation of any events occurring during follow up. The primary endpoint was ipsilateral stroke < 30 days. Secondary endpoints included re-operations due to neck haematoma and < 30 day ipsilateral stroke, > 30 day ipsilateral stroke, all stroke > 30 days, and all cause mortality. 2 495 patients underwent eversion CEA and 6 710 conventional CEA for symptomatic carotid stenosis. The most commonly used patch material was Dacron (n = 3 921), followed by PTFE (n = 588) and bovine pericardium (n = 413). A total of 1 788 patients underwent conventional CEA with primary closure. Two hundred and seventy-three patients (3.0%) had a stroke < 30 days. Primary closure was associated with an increased risk of ipsilateral stroke and stroke or death <30 days: odds ratio 1.7 (95% confidence interval [CI] 1.2 – 2.4, p =.002); and 1.5 (95% CI 1.2 – 2.0), respectively. During follow up (median 4.2 years), 592 patients had any form of stroke and 1 492 died. There was no significant difference in long term risk of ipsilateral stroke, all stroke, or death depending on surgical technique or patch material. There was an increased risk of ipsilateral stroke < 30 days in patients operated on with primary closure compared with eversion CEA and patch angioplasty. There was no difference between primary closure, different patch types, or eversion after the peri-operative phase. [ABSTRACT FROM AUTHOR]

We study radial expansion, cavitation, and eversion of spherical shells made of incompressible, isotropic, and functionally graded (i.e. inhomogeneous) soft (or rubber-like) materials that are increasingly being used in prosthetics, seals, tires, flexible electronics, soft robots, and many other applications. We consider all geometric and material nonlinearities and assume the sphere material to be Mooney–Rivlin material whose two parameters, C 1(R) and C 2(R), are smooth functions of the radial coordinate, R, in the stress-free undeformed configuration. The shell's inversion illustrates non-uniqueness of solutions in finite elasticity since sphere's bounding surfaces are traction free in the reference and the deformed configurations but stresses/strains in the interior are different. Assuming that a shell under a dead tensile pressure on the outer surface cavitates when the radial stretch at the inner surface equals four, we delineate effects of functions C 1(R) and C 2(R) on the cavitation pressure. It is found that for power-law variations with indices m and n, respectively, for C 1(R) and C 2(R) the cavitation pressure can be controlled by suitably choosing m and n. Large positive and negative values of m and n are deleterious for a sphere loaded only by a pressure on the inner surface since they produce high hoop stresses within the sphere. Other results given in the paper will enable one to tailor functions C 1(R) and C 2(R) to either mitigate cavitation or initiate it at a desired pressure or have prescribed through-the-thickness variations of stresses to optimize sphere's performance. [ABSTRACT FROM AUTHOR]

Background and Objectives: To evaluate the efficacy of bladder-prostatic muscle reconstruction and bladder neck eversion anastomosis in the recovery of urinary continence after robot-assisted radical prostatectomy (RARP). Materials and Methods: From January 2020 to May 2022, 69 patients who underwent RARP in our hospital were recruited. Thirty-seven patients underwent RARP with the Veil of Aphrodite technique (control group). On the basis of the control group, 32 patients underwent bladder-prostatic muscle reconstruction and bladder neck eversion anastomosis during RARP (observation group). The recovery of urinary continence was followed up at 24 h and 1, 4, 12, and 24 weeks after catheter removal. Results: There were no significant differences in operative time (127.76 ± 21.23 min vs. 118.85 ± 24.71 min), blood loss (118.27 ± 16.75 mL vs. 110.77 ± 19.63 mL), rate of leakage (3.13% vs. 2.70%), rate of positive surgical margin (6.25% vs. 10.81%), or postoperative Gleason score [7 (6–8) vs. 7 (7–8)] between the observation group and the control group (p > 0.05). After catheter removal, the rates of urinary continence at 24 h, 1 week, 4 weeks, 12 weeks, and 24 weeks were 46.88%, 68.75%, 84.38%, 90.63%, and 93.75% in the observation group, respectively. Meanwhile, the rates of urinary continence in the control group were 21.62%, 37.84%, 62.16%, 86.49%, and 91.89%, respectively. There was a significant difference between the two groups (p = 0.034), especially at 24 h, 1 week, and 4 weeks after catheter removal (p < 0.05). Conclusions: Bladder-prostatic muscle reconstruction and bladder neck eversion anastomosis were beneficial to the recovery of urinary continence after RARP, especially early urinary continence. [ABSTRACT FROM AUTHOR]

The amygdala, a complex array of nuclei in the forebrain, controls emotions and emotion-related behaviors in vertebrates. Current research aims to understand the amygdala's evolution in ray-finned fish such as zebrafish because of the region's relevance for social behavior and human psychiatric disorders. Clear-cut molecular definitions of the amygdala and its evolutionary-developmental relationship to the one of mammals are critical for zebrafish models of affective disorders and autism. In this review, I argue that the prosomeric model and a focus on the olfactory system's organization provide ideal tools for discovering deep ancestral relationships between the emotional systems of zebrafish and mammals. The review's focus is on the "extended amygdala," which refers to subpallial amygdaloid territories including the central (autonomic) and the medial (olfactory) amygdala required for reproductive and social behaviors. Amphibians, sauropsids, and lungfish share many characteristics with the basic amygdala ground plan of mammals, as molecular and hodological studies have shown. Further exploration of the evolution of the amygdala in basally derived fish vertebrates requires researchers to test these "tetrapod-based" concepts. Historically, this has been a daunting task because the forebrains of basally derived fish vertebrates look very different from those of more familiar tetrapod ones. An extreme case are ray-finned fish (Actinopterygii) like zebrafish because their telencephalon develops through a distinct outward-growing process called eversion. To this day, scientists have struggled to determine how the everted telencephalon compares to non-actinopterygian vertebrates. Using the teleost zebrafish as a genetic model, comparative neurologists began to establish quantifiable molecular definitions that allow direct comparisons between ray-finned fish and tetrapods. In this review, I discuss how the most recent discovery of the zebrafish amygdala ground plan offers an opportunity to identify the developmental constraints of amygdala evolution and function. In addition, I explain how the zebrafish prethalamic eminence (PThE) topologically relates to the medial amygdala proper and the nucleus of the lateral olfactory tract (nLOT). In fact, I consider these previously misinterpreted olfactory structures the most critical missing evolutionary links between actinopterygian and tetrapod amygdalae. In this context, I will also explain why recognizing both the PThE and the nLOT is crucial to understanding the telencephalon eversion. Recognizing these anatomical hallmarks allows direct comparisons of the amygdalae of zebrafish and mammals. Ultimately, the new concepts of the zebrafish amygdala will overcome current dogmas and reach a holistic understanding of amygdala circuits of cognition and emotion in actinopterygians. [ABSTRACT FROM AUTHOR]

Background: Although the ankle strategy is important for achieving frontal plane stability during one-leg stance, previously developed powered ankle-foot orthoses (PAFOs) did not involve ankle strategies because of hardware limitations. Weakness of movement in frontal plane is a factor that deteriorates gait stability and increases fall risk so it should not be overlooked in rehabilitation. Therefore, we used PAFO with subtalar joint for frontal plane movement and tried to confirm that the existence of it is important in balancing through clinical experiments.Methods: We developed a proportional CoP controller to assist ankle strategy or stabilizing moment and enhance eversion to compensate for the tilting moment with 2 dof PAFO. It was true experimental study, and we recruited seven healthy subjects (30 ± 4 years) who did not experience any gait abnormality participated in walking experiments for evaluating the immediate effect of subtalar joint of PAFO on their gait stability. They walked on the treadmill with several cases of controllers for data acquisitions. Indices of gait stability and electromyography for muscle activity were measured and Wilcoxon signed-rank tests were used to identify meaningful changes.Results: We found that subjects were most stable during walking (in terms of largest Lyapunov exponents, p < 0.008) with the assistance of the PAFO when their electromyographic activity was the most reduced (p < 0.008), although postural sway increased when a proportional CoP controller was used to assist the ankle strategy (p < 0.008). Other indices of gait stability, kinematic variability, showed no difference between the powered and unpowered conditions (p > 0.008). The results of the correlation analysis indicate that the actuator of the PAFO enhanced eversion and preserved the location of the CoP in the medial direction so that gait stability was not negatively affected or improved.Conclusions: We verified that the developed 2 dof PAFO assists the ankle strategy by compensating for the tilting moment with proportional CoP controller and that wearer can walk in a stable state when the orthosis provides power for reducing muscle activity. This result is meaningful because an ankle strategy should be considered in the development of PAFOs for enhancing or even rehabilitating proprioception. Trial registration 7001988-202003-HR-833-03. [ABSTRACT FROM AUTHOR]

In the era of technological advancement, the practice of microsurgery has virtually remained unchanged for the last few decades. In this article, the authors describe innovative three jaw microsurgery clamps which provide a novel vessel eversion feature. The advantages of these clamps include better visibility of the posterior wall resulting in lower incidence of back walling and incomplete bites. These clamps also eliminate the need to flip the clamps as a result of better posterior wall visualisation. These unique microsurgery clamps not only ease the arduous, technique sensitive field of microsurgery in the operating room, but can also serve as a tool for the training of future reconstructive surgeons, thereby reducing the steep learning curve considerably. [ABSTRACT FROM AUTHOR]

This article aims to describe the narrative and thematic processes related to catastrophic time in Antonio Moresco’s The Games of Eternity. A work of unusual vastness due to its characteristic feature: breaking with the mimetic conventions of representation and perception, through the principle of reversal as a principle of openness.

• Interactions between hip and foot factors predict the magnitude of foot pronation. • These interactions of foot and hip factors are non-linear. • The profiles help clinicians identify how these factors interact in walking. Interactions between hip and foot biomechanical factors may result in different magnitudes of foot pronation during walking. To investigate non-linear interactions between hip and foot biomechanical factors and their capability to predict foot pronation during walking and identify the profiles of biomechanical factors that predict greater and lower pronation. This is a cross-sectional study. Fifty-one women were classified into greater and lower foot pronation during walking. Biomechanical factors measured: (1) foot-ankle varus alignment, (2) hip passive stiffness, (3) isokinetic eccentric strength of hip external rotators, and (4) foot abduction angle. Classification and regression trees (CART) were used to investigate non-linear interactions that predict greater and lower foot pronation. Four main profiles of biomechanical factors were identified as related to greater and lower foot pronation. Profiles for greater pronation were: (1) varus >25.83°; (2) interaction between varus ≤25.83° and hip stiffness ≤0.09 Nm/rad kg-1; (3) interaction between varus ≤25.83°, hip stiffness >0.09 Nm/rad kg-1, and foot abduction >19.58° The profile for lower pronation involved an interaction among varus ≤25.83°, hip stiffness >0.09 Nm/rad kg-1, and foot abduction ≤19.58° The model had 61% sensitivity and 96% specificity, with the total prediction of 78%. The area under the ROC curve was 0.79 (p = 0.001). Foot-ankle varus, hip passive stiffness, and foot abduction predicted greater and lower foot pronation. Non-linear interactions between hip and foot factors influence the magnitude of foot pronation during walking. The observed profiles help identify which combinations of biomechanical factors should be assessed in individuals with increased or reduced pronation. [ABSTRACT FROM AUTHOR]

The outcomes of carotid surgery are commonly evaluated using parameters such as mortality and stroke. The importance of these parameters is based on doctors’ and scientific perspectives. Presently, patient centered health care aims to value the evaluation from patients’ perspective, mostly using Patient-Reported Outcomes (PROs). The true significance of outcomes of carotid surgery that matter most to the patients is largely unknown. The aim of this study is to identify and verify the patients’ perspective on carotid surgery for patients with a symptomatic and significant carotid stenosis.An exploratory semi-structured focus group discussion will be used, as a quality research method. Three groups consisting of 8 patients (n = 24), who underwent the carotid endarterectomy because of a significant and symptomatic stenosis of the internal carotid artery, will be enrolled. If data saturation is not reached, the sample size will be expanded. An expert medical psychologist will lead the focus group discussions. The interviews will be recorded, transcribed ‘verbatim’ and analyzed after each session. Items valuable to patients regarding their surgery and recovery will be discussed. This protocol will be published prior to the start of the Focus Group Discussion.Patients’ perspective on outcomes regarding their carotid surgery will be explored and tried to be identified. The results of the focus group discussions may fuel the ongoing global discussion on improving evidence based and patient reported outcome measures and will help the clinical physician to ‘understand’ their patients better. Focus group discussions may aid in the purpose of verification of PROs and PROMs. [ABSTRACT FROM AUTHOR]

Zebrafish telencephalon acquires an everted morphology by a two-step process that occurs from 1 to 5 days post-fertilization (dpf). Little is known about how this process affects the positioning of discrete telencephalic cell populations, hindering our understanding of how eversion impacts telencephalic structural organization. In this study, we characterize the neurochemistry, cycle state and morphology of an EGFP positive (+) cell population in the telencephalon of Et(gata2 : EGFP)bi105 transgenic fish during eversion and up to 20dpf. We map the transgene insertion to the early-growth-response-gene-3 (egr3) locus and show that EGFP expression recapitulates endogenous egr3 expression throughout much of the pallial telencephalon. Using the gata2:EGFP bi105 transgene, in combination with other well-characterized transgenes and structural markers, we track the development of various cell populations in the zebrafish telencephalon as it undergoes the morphological changes underlying eversion. These datasets were registered to reference brains to form an atlas of telencephalic development at key stages of the eversion process (1dpf, 2dpf, and 5dpf) and compared to expression in adulthood. Finally, we registered gata2:EGFPbi105 expression to the Zebrafish Brain Browser 6dpf reference brain (ZBB, see Marquart et al., 2015, 2017; Tabor et al., 2019), to allow comparison of this expression pattern with anatomical data already in ZBB. [ABSTRACT FROM AUTHOR]

The post-PC era of computing offers digital rhetors an opportunity to innovate their inventional approaches. The new era is one in which an ecology of networked, distributed, sensor-based devices amplify our perceptions of self and world by changing the ecological relations that define our connections to our techno-social environments. By extending Casey Boyle’s posthuman practice of rhetorical invention to the new computational era, rhetoricians can develop digital interactive projects that move participants by amplifying the choric bases of their perceptions of self and world.

Zebrafish telencephalon acquires an everted morphology by a two-step process that occurs from 1 to 5 days post-fertilization (dpf). Little is known about how this process affects the positioning of discrete telencephalic cell populations, hindering our understanding of how eversion impacts telencephalic structural organization. In this study, we characterize the neurochemistry, cycle state and morphology of an EGFP positive (+) cell population in the telencephalon of Et(gata2:EGFP)bi105 transgenic fish during eversion and up to 20dpf. We map the transgene insertion to the early-growth-response-gene-3 (egr3) locus and show that EGFP expression recapitulates endogenous egr3 expression throughout much of the pallial telencephalon. Using the gata2:EGFPbi105 transgene, in combination with other well-characterized transgenes and structural markers, we track the development of various cell populations in the zebrafish telencephalon as it undergoes the morphological changes underlying eversion. These datasets were registered to reference brains to form an atlas of telencephalic development at key stages of the eversion process (1dpf, 2dpf, and 5dpf) and compared to expression in adulthood. Finally, we registered gata2:EGFPbi105 expression to the Zebrafish Brain Browser 6dpf reference brain (ZBB, see Marquart et al., 2015, 2017; Tabor et al., 2019), to allow comparison of this expression pattern with anatomical data already in ZBB.

While exploring complex unmapped spaces is a persistent challenge for robots, plants are able to reliably accomplish this task. In this work we develop branching robots that deploy through an eversion process that mimics key features of plant growth (i.e., apical extension, branching). We show that by optimizing the design of these robots, we can successfully traverse complex terrain even in unseen instances of an environment. By simulating robot growth through a set of known training maps and evaluating performance with a reward heuristic specific to the intended application (i.e., exploration, anchoring), we optimized robot designs with a particle swarm algorithm. We show these optimization efforts transfer from training on known maps to performance on unseen maps in the same type of environment, and that the resulting designs are specialized to the environment used in training. Furthermore, we fabricated several optimized branching everting robot designs and demonstrated key aspects of their performance in hardware. Our branching designs replicated three properties found in nature: anchoring, coverage, and reachability. The branching designs were able to reach 25% more of a given space than non-branching robots, improved anchoring forces by 12.55×, and were able to hold greater than 100× their own mass (i.e., a device weighing 5 g held 575 g). We also demonstrated anchoring with a robot that held a load of over 66.7 N at an internal pressure of 50 kPa. These results show the promise of using branching vine robots for traversing complex and unmapped terrain.

Abstract We present a rare congenital condition in a Persian newborn characterized by the unilateral everted upper eyelid. This report aimed to create awareness among neonatologists and ophthalmologists who are first‐time viewers of this condition and lead them to choose the appropriate management.

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and Objectives: To evaluate the efficacy of bladder-prostatic muscle reconstruction and bladder neck eversion anastomosis in the recovery of urinary continence after robot-assisted radical prostatectomy (RARP). Materials and Methods: From January 2020 to May 2022, 69 patients who underwent RARP in our hospital were recruited. Thirty-seven patients underwent RARP with the Veil of Aphrodite technique (control group). On the basis of the control group, 32 patients underwent bladder-prostatic muscle reconstruction and bladder neck eversion anastomosis during RARP (observation group). The recovery of urinary continence was followed up at 24 h and 1, 4, 12, and 24 weeks after catheter removal. Results: There were no significant differences in operative time (127.76 ± 21.23 min vs. 118.85 ± 24.71 min), blood loss (118.27 ± 16.75 mL vs. 110.77 ± 19.63 mL), rate of leakage (3.13% vs. 2.70%), rate of positive surgical margin (6.25% vs. 10.81%), or postoperative Gleason score [7 (6–8) vs. 7 (7–8)] between the observation group and the control group (p > 0.05). After catheter removal, the rates of urinary continence at 24 h, 1 week, 4 weeks, 12 weeks, and 24 weeks were 46.88%, 68.75%, 84.38%, 90.63%, and 93.75% in the observation group, respectively. Meanwhile, the rates of urinary continence in the control group were 21.62%, 37.84%, 62.16%, 86.49%, and 91.89%, respectively. There was a significant difference between the two groups (p = 0.034), especially at 24 h, 1 week, and 4 weeks after catheter removal (p < 0.05). Conclusions: Bladder-prostatic muscle reconstruction and bladder neck eversion anastomosis were beneficial to the recovery of urinary continence after RARP, especially early urinary continence.

Achilles tendinopathy (AT) and medial tibial stress syndrome (MTSS) are two of the most common running-related injuries. In a previous study investigating running biomechanics before and after a six-week transition to maximal running shoes, two runners dropped out of this study due to Achilles pain and shin pain, respectively. The purpose of this case series was to investigate running biomechanics in those two runners, identifying potential causes for injury in relation to maximal shoe use. Running biomechanics were collected in a laboratory setting for these two runners wearing both a maximal running shoe and traditional running shoe before the six-week transition using an 8-camera motion capture system and two embedded force plates. Both runners displayed prolonged eversion in the maximal shoe, which has been previously cited as a potential risk factor for developing Achilles tendinopathy and medial tibial stress syndrome. Relatively high loading rates and impact forces were also observed in the runner with shin pain in the maximal shoe, which may have contributed to their pain. More prospective research on injury rates in individuals running in maximal shoes is needed. [ABSTRACT FROM AUTHOR]

Background: The socket reaction moment (SRM) has been reported to change because of alignment changes in transtibial prosthetic sockets. However, the influence of prosthetic foot alignment on SRM remains unclear.Research Question: Are SRMs predictable from alignment changes of prosthetic feet?Methods: Ten users of transtibial prostheses participated in this study. Under five alignment conditions (3 ° plantarflexion and dorsiflexion, 6 ° inversion and eversion, and baseline alignment), temporal-spatial parameters and sagittal and coronal SRMs were measured during walking. Cadence, walking speed, step time, single support time, and step length were compared. The maximum/minimum SRM, % stance (timing) of the maximum/minimum SRM, Zero-cross, and SRMs at 5 %, 20 %, and 75 % stance were extracted and compared. Repeated measures analysis of variance or Friedman tests, and linear regression analyses were conducted for statistical analyses (i.e., alignment conditions as independent variables and SRM parameters as dependent variables).Results: The SRMs at 5%, 20 %, and 75 % stance showed significant differences under coronal angular changes. The minimum SRM, % stance of the minimum/maximum SRM, and Zero-cross showed significant differences under sagittal alignment changes. In linear regression analysis, the minimum SRM, % stance of the minimum/maximum SRM, SRM at 20 % stance, and Zero-cross were significant dependent variables in the sagittal plane. The maximum/minimum SRM, SRM at 20 % and 75 % stance, and % stance of the minimum SRM were significant dependent variables in the coronal plane.Significance: The results indicated that the changes in prosthetic feet angles may predict the magnitude of SRM (maximum/minimum SRM, SRM at 20 % and 75 % stance) in the coronal plane, and the timing of SRM (Zero-cross, % stance of the maximum/minimum SRM) in the sagittal plane. These findings suggest that the SRM may be useful for evaluating foot alignment in transtibial prostheses. [ABSTRACT FROM AUTHOR]

Two biomechanical mechanisms for the development of Achilles tendinopathy in runners have been proposed: A whipping mechanism characterized by prolonged and excessive rearfoot eversion, and a tearing mechanism characterized by high eccentric plantar flexor forces. The purpose of this pilot study was to determine if runners with and without a history of Achilles tendinopathy exhibited gait biomechanics consistent with either of these mechanisms. Seven male runners with previous or current Achilles tendinopathy and seven healthy male control runners were evaluated by three-dimensional gait analysis. Peak rearfoot eversion angle, rearfoot eversion excursion, duration of rearfoot eversion, and peak rearfoot inversion angle were compared between groups to evaluate the whipping mechanism of injury. Peak dorsiflexion angle, peak dorsiflexion velocity, and peak ankle power absorption were compared between groups to evaluate the tearing mechanism. Additionally, rearfoot eversion angle and sagittal plane ankle power waveforms were compared between groups using statistical parametric mapping. There were no differences in any rearfoot eversion, inversion, or dorsiflexion variables or waveforms during running in the Achilles tendinopathy group compared to controls. Rearfoot strike runners with Achilles tendinopathy do not exhibit running biomechanics consistent with either the whipping or tearing mechanisms of injury. • Peak rearfoot eversion is not different in runners with and without a history of Achilles tendinopathy. • Peak power absorption is not different in runners with and without a history of Achilles tendinopathy. • Peak dorsiflexion velocity and angle are not different in runners with and without a history of Achilles tendinopathy. • Rearfoot eversion and sagittal plane power waveforms are not different among runners with and without a history of Achilles tendinopathy. [ABSTRACT FROM AUTHOR]

The present paper is the first comparative study on the astroglia of several actinopterygian species at different phylogenetical positions, teleosts (16 species), and non-teleosts (3 species), based on the immunohistochemical staining of GFAP (glial fibrillary acidic protein), the characteristic cytoskeletal intermediary filament protein, and immunohistochemical marker of astroglia. The question was, how the astroglial architecture reflexes the high diversity of this largest vertebrate group. The actinopterygian telencephalon has a so-called ‘eversive’ development in contrast to the ‘evagination’ found in sarcopterygii (including tetrapods). Several brain parts either have no equivalents in tetrapod vertebrates (e.g., torus longitudinalis, lobus inferior, lobus nervi vagi), or have rather different shapes (e.g., the cerebellum). GFAP was visualized applying DAKO polyclonal anti-GFAP serum. The study was focused mainly on the telencephalon (eversion), tectum (visual orientation), and cerebellum (motor coordination) where the evolutionary changes were most expected, but the other areas were also investigated. The predominant astroglial elements were tanycytes (long, thin, fiber-like cells). In the teleost telencephala a ‘fan-shape’ re-arrangement of radial glia reflects the eversion. In bichir, starlet, and gar, in which the eversion is less pronounced, the ‘fan-shape’ re-arrangement did not form. In the tectum the radial glial processes were immunostained, but in Ostariophysi and Euteleostei it did not extend into their deep segments. In the cerebellum Bergmann-like glia was found in each group, including non-teleosts, except for Cyprinidae. The vagal lobe was uniquely enlarged and layered in Cyprininae, and had a corresponding layered astroglial system, which left almost free of GFAP the zones of sensory and motor neurons. In conclusion, despite the diversity and evolutionary alterations of Actinopterygii brains, the diversity of the astroglial architecture is moderate. In contrast to Chondrichthyes and Amniotes; in Actinopterygii true astrocytes (stellate-shaped extraependymal cells) did not appear during evolution, and the expansion of GFAP-free areas was limited.

Unpowered braces and exoskeletons, which are often made of carbon fiber reinforced plastic (CFRP), can assist lower limb movements and can be worn permanently. Furthermore, braces to be worn at all times must not hinder the change of direction, as this movement is nearly as essential as straight gait in daily life. Ankle joint movements, especially inversion and eversion, play a key role in changing the direction during walking. However, in the case of conventional short leg braces, the range of motion is limited because the single wide CFRP blade placed at the back of the leg cannot deform elastically. In this study, a gait assist system with two CFRP blades on the lateral and medial sides of the leg was developed. The system could effectively assist the gait and did not inhibit the change in the direction. [ABSTRACT FROM AUTHOR]

The present paper is the first comparative study on the astroglia of several actinopterygian species at different phylogenetical positions, teleosts (16 species), and non-teleosts (3 species), based on the immunohistochemical staining of GFAP (glial fibrillary acidic protein), the characteristic cytoskeletal intermediary filament protein, and immunohistochemical marker of astroglia. The question was, how the astroglial architecture reflexes the high diversity of this largest vertebrate group. The actinopterygian telencephalon has a so-called 'eversive' development in contrast to the 'evagination' found in sarcopterygii (including tetrapods). Several brain parts either have no equivalents in tetrapod vertebrates (e.g., torus longitudinalis, lobus inferior, lobus nervi vagi), or have rather different shapes (e.g., the cerebellum). GFAP was visualized applying DAKO polyclonal anti-GFAP serum. The study was focused mainly on the telencephalon (eversion), tectum (visual orientation), and cerebellum (motor coordination) where the evolutionary changes were most expected, but the other areas were also investigated. The predominant astroglial elements were tanycytes (long, thin, fiber-like cells). In the teleost telencephala a 'fan-shape' re-arrangement of radial glia reflects the eversion. In bichir, starlet, and gar, in which the eversion is less pronounced, the 'fan-shape' re-arrangement did not form. In the tectum the radial glial processes were immunostained, but in Ostariophysi and Euteleostei it did not extend into their deep segments. In the cerebellum Bergmann-like glia was found in each group, including non-teleosts, except for Cyprinidae. The vagal lobe was uniquely enlarged and layered in Cyprininae, and had a corresponding layered astroglial system, which left almost free of GFAP the zones of sensory and motor neurons. In conclusion, despite the diversity and evolutionary alterations of Actinopterygii brains, the diversity of the astroglial architecture is moderate. In contrast to Chondrichthyes and Amniotes; in Actinopterygii true astrocytes (stellate-shaped extraependymal cells) did not appear during evolution, and the expansion of GFAP-free areas was limited. [ABSTRACT FROM AUTHOR]

We develop a general minmax procedure in Euclidian spaces for constructing Willmore surfaces of non-zero indices. We apply this procedure to the Willmore minmax sphere eversion in the 3-dimensional Euclidian space. We compute the cost of sphere eversion in terms of Willmore energies of the Willmore spheres in ℝ³. [ABSTRACT FROM AUTHOR]

Objectives: Endarterectomy is the treatment of choice for arterial occlusive disease of the femoral bifurcation. Longitudinal arteriotomy and prosthetic patch angioplasty is the standard technique but, due to the increasing concerns with prosthetic-related infections and multidrug-resistant pathogens our group adopted an alternative approach. We present our experience with eversion femoral endarterectomy.Methods: All patients submitted to eversion femoral endarterectomy in a single institution during 2016-2019 were retrospectively analyzed. Patient demographics, surgical data, and complications were captured from medical records.Results: Nineteen patients, 84.2% male and a median age of 67 years (IQR 62-78) were submitted to eversion femoral endarterectomy with a median follow-up of 180 days (IQR 71-395). Seventeen (89.4%) patients were treated for chronic limb ischemia and the other two were submitted to femoral endarterectomy during endovascular aortic aneurysm repair. Most of the patients had smoking history (84.2%), followed by hypertension (68.4%), dyslipidemia (63.2%), coronary heart disease (29.4%), and diabetes (26.3%). Only 3 patients (15.8%) were submitted exclusively to endarterectomy, 13 (68.4%) were submitted to endarterectomy as an adjuvant for peripheral endovascular treatment, 2 (10.5%) as a concomitant procedure to endovascular repair of aortic aneurysm, and 1 (5.3%) was complemented with thrombectomy of the femoro-popliteal sector. Primary patency rates were 100% and 87.5% (CI (38.7-98.1)) at 6 and 12 months, respectively. Primary-assisted and secondary patency rates were 100%. The 30-day mortality rate was 5.3% (n = 1) and complication rate 10.5% (n = 2). One patient complicated with acute renal disease related to rhabdomyolysis. Another patient developed a wound-related hematoma treated with surgical drainage, but died three days after consequent to ischemia-reperfusion injury.Conclusions: Eversion femoral endarterectomy is a safe and feasible technique, with good patency results and respecting the concept of leaving nothing behind. A careful control of the proximal and distal endpoints is essential for the success of the technique. [ABSTRACT FROM AUTHOR]

Foot Pronation, also called as "eversion" is a normal and necessary component of the gait cycle. However, abnormal pronation occurs when foot pronates, when actually it shouldn't. It occurs during the half of the stance phase. The foot rolls inward when one lands their foot on surface while walking and running. The complementing structures of the ankle or foot complex permits both stability and mobility depending on conditions acting on it. This article presents on overview on current knowledge on pronated foot and focuses on biomechanics, etiology diagnosis and treatment strategies, conservative treatment. [ABSTRACT FROM AUTHOR]

Carotid endarterectomy (CEA) is the main procedure in carotid surgery, as well as the most frequent vascular procedure. Two techniques of CEA are available : eversion and conventional plus patch angioplasty. Eversion CEA is anatomic procedure that reduces ischemic and total operative time. Simultaneous correction of the joined carotid kinking and coiling is possible, easy and safe, while the usage of patch is excluded. Thanks to oblique shape of anastomosis, eversion CEA is associated with low risk of long-term restenosis. The false anastomotic aneurysms occurrence is very rare, almost impossible after eversion CEA. However, the usage of carotid shunt during eversion CEA is not always simple, while proximal or distal extension of the carotid plaque can make eversion CEA more difficult and risky. Eversion CEA should be the first choice in carotid surgery. Conventional CEA is indicated in cases when carotid plaque is extended more than usual, as well as, if the usage of carotid shunt is necessary. [ABSTRACT FROM AUTHOR]

Studies on the functional morphology and evolution of genitalia have been crucial to understanding sexual traits in speciation, reproductive isolation and sexual selection in Coleoptera and insects in general. However, the focus of investigation of the intromittent organ of beetles was largely confined to the sclerotized elements of the aedeagus, whereas the membranous structures of the endophallus (=internal sac) have often not been adequately considered. Using a micro-operating technique, we observed living male rove beetles and found five different types of endophallus eversion and related morphological modifications. Analysing genital data of a larger sample of Xantholinini, we could demonstrate that endophallus complexity and modifications tend to vary inversely with the median lobe (penis: intromittent organ). Our comparative morphological study, combined with a molecular phylogenetic analysis, suggests that endophallus spiralling occurring after endophallus eversion is an innovation in beetle evolution. [ABSTRACT FROM AUTHOR]

Background: Tibial stress fractures (TSF) are a common running related injury. Specific risk factors include increased rearfoot eversion and increased vertical instantaneous and average loading rates (VILR and VALR, respectively). Since these risk factors are mechanical in nature, certain types of running shoes may be able to reduce these risk factors for TSF. The objective of this study was to determine the effects of maximalist, stability, and flexible (commercially marketed as minimalist) running shoes on specific risk factors for TSF in male and female runners. Methods: Fourteen recreation runners were recruited for this study, 7 males and 7 females. A 14-camera motion capture system and three force plates were used to capture each subject's kinematics and kinetics. Subjects ran in maximalist (Hoka Bondi 5), stability (Nike Structures), neutral (Nike Pegasus), and flexible (Nike Free) shoes. Results: Among males there was a significant increase in ankle internal rotation ROM in the maximalist shoe compared to neutral. There was also a significant decrease in ankle internal rotation ROM in the flexible shoe compared to neutral. Among females there was a significant reduction in peak ankle eversion and ankle eversion ROM. Conclusions: The results of this study suggest that the maximalist shoes may reduce the pronation component of TSF risk factors in female runners. The maximalist shoes were able to reduce the peak ankle eversion and ROM. This is likely due to the specific design mechanism of the maximalist shoe to control foot motion. [ABSTRACT FROM AUTHOR]

The purpose of this study was to investigate the effects of transversely sloped ballasted walking surface on gait and rearfoot motion (RFM) parameters. Motion analysis was performed with 20 healthy participants (15 male and 5 female) walking in six surface-slope conditions: two surfaces (solid and ballasted) by three slopes (0, 5, and 10 degrees). The gait parameters (walking velocity, step length, step rate, step width, stance time, and toe-out angle) showed significant surface effect (p = .004) and surface-slope interaction (p = .017). The RFM motion parameters (peak everted/inverted position, eversion/inversion velocity, and acceleration) revealed significant surface (p = .004) and slope (p = .024) effects. The ballasted conditions showed more cautious gait patterns with lower walk velocity, step length, and step rate and longer stance time. In the RFM parameters, the slope effect was more notable in the solid conditions due to the gait adaptations in the ballasted conditions. Ballast conditions showed reduced inversion and increased eversion and RFM range. The RFM data were comparable to other typical walking conditions but smaller than those from running. [ABSTRACT FROM AUTHOR]

Despite extensive research on running mechanics, there is still a knowledge gap with respect to the degree of relationship between mediolateral ground reaction forces (ML-GRF) and foot pronation. Our goal was to investigate whether differences exist in ML-GRF among runners that exhibit different degrees of pronation. Seventeen male and 13 female recreational runners ran with and without shoes while ML-GRF and frontal kinematics were collected simultaneously. Subjects were divided into groups based upon their peak eversion (low pronation, middle pronation, high pronation). Discrete parameters from the ML-GRF were peak forces, respective times of occurrence, and impulses. No significant differences were found between groups regarding the magnitude of ML-GRF. Based upon the relative times of occurrence, the peak medial GRF occurred closer to the peak eversion than the peak lateral GRF. Findings support the idea that the ML-GRF have less to do with pronation than previous research suggested. [ABSTRACT FROM AUTHOR]

Context: There is limited information on fatigue of the evertors on frontal plane joint position sense (JPS). Objective: To examine the effects of isokinetic concentric-eccentric fatigue of the evertors on frontal plane JPS of the ankle. Design: A 2 × 4 factorial design. Setting: Research Laboratory. Patients or Other Participants: 40 male and female healthy subjects. Interventions: JPS was tested at 10° and 20° of inversion and 5° and 10° of eversion in a nonfatigued/fatigued condition. After fatigue of evertors was determined on an isokinetic device, post fatigue testing of JPS occurred. Main Outcome Measures: JPS absolute error (AE) for inversion and eversion. Results: Main effect for condition and angle were significant with pre/post fatigue. There were overestimation of angles postfatigue with AE greater at 20° of inversion (P = .003), followed by 10° of inversion (P < .001), 10° of eversion (P = .005), and 5° of eversion (P = .005). Conclusion: When the ankle evertors were fatigued, the AE for JPS was significantly higher at all test angles. [ABSTRACT FROM AUTHOR]

Introduction: Prompt carotid endarterectomy for stroke prevention remains an essential component of treatment for symptomatic carotid stenosis. There exist a number of techniques, most commonly, access via a longitudinal arteriotomy for conventional carotid endarterectomy (CCEA), but eversion endarterectomy (ECEA) may also be used. Neither has been definitively proven as superior. We outline the experience in our institution of these two approaches. Methods: All patients who had surgery over a 7-year period (2009–2015) under a single consultant vascular surgeon were included in this analysis. Midway through the study period, the operative technique was changed from exclusively CCEA to exclusively ECEA. Demographics, outcomes, and complications, including re-intervention and restenosis rate were gathered from a variety of sources to maximise data reliability and accuracy. Results: Two hundred four interventions were performed during the study period; 114 in the CCEA group, 90 in the ECEA group. Demographics and indication for surgery was well matched between groups. A significant difference was found between operative time (128.6 ± 2.3 vs 70.7 ± 12.2 min) and need for shunting (19.3% vs 1.9%), between CCEA and ECEA. Haematoma rates were higher in the ECEA group (7.7% vs 1.7%), but this can be attributed to differing use of perioperative anti-platelet therapy. There was no other statistical difference in morbidity, mortality, restenosis rates, or re-intervention rates between groups. Conclusion: These two carotid endarterectomy techniques are equivalent in terms of outcome, but ECEA can be performed in a significantly shorter operative time and reduces need for shunting. [ABSTRACT FROM AUTHOR]

Background: Gastrocnemius medialis (GM) and lateralis (GL) act at the ankle complex in the sagittal and frontal planes and there is evidence that their actions can be somewhat uncoupled from each other. Some independence of GM and GL from each other could be advantageous, e.g. to stabilise the ankle complex in unstable walking conditions. Given the compartmentalised structure of the Achilles tendon, the sub-tendons of GM and GL may exhibit different elongation during plantarflexion contractions, particularly with the foot in different frontal plane positions.Research Questions: METHODS: Sub-tendon elongation was determined from 18 participants during ramped isometric plantarflexion contractions to 70% of their maximum voluntary contraction (MVC) level with the foot in neutral, inversion and eversion. One-dimensional statistical parametric mapping was applied to determine elongation differences.Results: Elongation within a sub-tendon did not differ in the three foot positions. Elongation was similar between both sub-tendons at very low contraction levels, but GM sub-tendon elongation exceeded GL sub-tendon displacement significantly from 30% MVC. The elongation differences between the sub-tendons were not affected by foot position.Significance: Greater GM sub-tendon elongation is likely caused by the greater force production capability of GM but may also indicate that the sub-tendons of GM and GL have different mechanical properties, which is currently unknown. Elongation differences were contraction level dependent suggesting that contributions of GM and GL to plantarflexion torque may also be contraction level dependent. [ABSTRACT FROM AUTHOR]

Although the cerebral hemispheres are among the defining characters of vertebrates, each vertebrate class is characterized by a different anatomical organization of this structure, which has become highly problematic for comparative neurobiology. In this article, we discuss some mechanisms involved in the generation of this morphological divergence, based on simple spatial constraints for neurogenesis and mechanical forces generated by increasing neuronal numbers during development, and the different cellular strategies used by each group to overcome these limitations. We expect this view to contribute to unify the diverging vertebrate brain morphologies into general, simple mechanisms that help to establish homologies across groups. RESEARCH HIGHLIGHTS: Mechanical forces constrain brain morphogenesisCellular mechanisms evolve to minimize these constraintsThis produces morphological divergence across vertebrates, challenging homology [ABSTRACT FROM AUTHOR]

Objective: Measure lower lip thickness and eversion in patients with cleft lip and palate (CLP) and maxillary hypoplasia. The specific aims were to (1) compare lower lip thickness/eversion in patients with CLP to noncleft controls with maxillary hypoplasia, (2) determine differences between patients with unilateral CLP (UCLP) and bilateral CLP (BCLP), and (3) document changes in the lower lip that occur with Le Fort I advancement. Design: Retrospective case–control study. Setting: Tertiary care center. Patients/Participants: Patients with available pre- and postoperative CT scans and 2D lateral photographs who had a Le Fort I advancement between 2009 and 2017. There were 32 patients with CLP (17 females; mean age 17.7 ± 1.9 years) and 33 noncleft controls (21 females; mean age 18.8 ± 2.6 years). Main Outcome Measures: Lower lip thickness and eversion. Results: Patients with CLP and maxillary hypoplasia have a significantly thicker lower lip (P =.019) and outward rotation of the vermilion border (P =.003) compared to noncleft controls. The lower lip was significantly thicker in patients with BCLP than in those with UCLP (P =.035). Lower lip thickness and rotation did not change after maxillary advancement. Conclusions: Patients with CLP and maxillary hypoplasia have a thicker and more everted lower lip than noncleft controls. Patients with BCLP have a significantly thicker lower lip than those with UCLP. Strain of the lower lip musculature appears to be an important contributor to the development of the cleft lip lower lip deformity. [ABSTRACT FROM AUTHOR]

Over the past decades, pronation has been discussed as a potential risk factor for injuries or as the mechanism behind impact damping. However, little is understood about pronation. The objectives of this paper were to (a) define and differentiate between the terms of pronation and eversion, (b + c) underline the importance and problematic aspects of pronation. The terms of pronation and eversion have often been used interchangeably in previous work. Both metrics describe rotations about two different axes of the foot. Due to the inaccessible location of the talus bone, mainly variables measuring eversion have been used to approximate the actual movement of pronation. However, the variety of surrogate variables does not facilitate the understanding of such particular foot movement. Since pronation is natural and it is necessary to successfully perform dynamic tasks such as running, normative values were developed for most pronation-associated variables. However, the optimal amount of pronation remains unknown. Furthermore, various aspects of pronation are widespread among researchers and clinicians. Despite their popularity, they are mis- or not well understood such as the impact damping paradigm and its link to running injuries. Especially, the exclusive causality between pronation and running injuries has been shown in neither cross-sectional nor longitudinal study designs with sufficient sample sizes. Therefore, it seems important to reconsider the topic of pronation from novel perspectives. [ABSTRACT FROM AUTHOR]

Background: A recent study suggested that maximal running shoes may increase the impact force and loading rate of the vertical ground-reaction force during running. It is currently unknown whether runners will adapt to decrease the impact force and loading rate over time. Purpose: To compare the vertical ground-reaction force and ankle kinematics between maximal and traditional shoes before and after a 6-week acclimation period to the maximal shoe. Study Design: Controlled laboratory study. Methods: Participants ran in a traditional running shoe and a maximal running shoe during 2 testing sessions 6 weeks apart. During each session, 3-dimensional kinematics and kinetics were collected during overground running. Variables of interest included the loading rate, impact peak, and active peak of the vertical ground-reaction force, as well as eversion and dorsiflexion kinematics. Two-way repeated measures analyses of variance compared data within participants. Results: No significant differences were observed in any biomechanical variable between time points. The loading rate and impact peak were higher in the maximal shoe. Runners were still everted at toe-off and landed with less dorsiflexion, on average, in the maximal shoe. Conclusion: Greater loading rates and impact forces were previously found in maximal running shoes, which may indicate an increased risk of injury. The eversion mechanics observed in the maximal shoes may also increase the risk of injury. A 6-week transition to maximal shoes did not significantly change any of these measures. Clinical Relevance: Maximal running shoes are becoming very popular and may be considered a treatment option for some injuries. The biomechanical results of this study do not support the use of maximal running shoes. However, the effect of these shoes on pain and injury rates is unknown. [ABSTRACT FROM AUTHOR]